# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/DNA_methylase.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: DNA_methylase [M=335] Accession: PF00145.17 Description: C-5 cytosine-specific DNA methylase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 3.2e-47 163.8 0.0 1e-46 162.1 0.0 1.9 1 sp|P26358-3|DNMT1_HUMAN Isoform 3 of DNA (cytosine-5)-methyl 1.6e-46 161.5 0.0 1.6e-46 161.5 0.0 3.3 1 sp|P26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 1.7e-46 161.4 0.0 1.7e-46 161.4 0.0 3.2 1 sp|P26358-2|DNMT1_HUMAN Isoform 2 of DNA (cytosine-5)-methyl 2e-46 161.1 0.0 2e-46 161.1 0.0 3.3 1 tr|F5GX68|F5GX68_HUMAN Cytosine-specific methyltransferase 2.8e-41 144.3 0.0 3.5e-41 143.9 0.0 1.1 1 sp|O14717|TRDMT_HUMAN tRNA (cytosine(38)-C(5))-methyltrans 3e-33 117.9 0.0 2.4e-19 72.1 0.0 2.1 2 sp|O14717-2|TRDMT_HUMAN Isoform B of tRNA (cytosine(38)-C(5) 6.6e-28 100.3 0.0 5.3e-14 54.6 0.0 2.1 2 sp|O14717-3|TRDMT_HUMAN Isoform C of tRNA (cytosine(38)-C(5) 2.4e-24 88.6 0.0 7.8e-24 86.9 0.0 1.6 1 tr|K7ENW7|K7ENW7_HUMAN DNA (cytosine-5)-methyltransferase 1 9.4e-16 60.3 0.3 7.2e-11 44.3 0.0 2.8 3 sp|Q9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3 1.1e-15 60.1 0.0 3e-11 45.5 0.0 2.3 2 sp|Q9Y6K1-2|DNM3A_HUMAN Isoform 2 of DNA (cytosine-5)-methyl 1.9e-15 59.4 0.0 7e-11 44.3 0.0 2.2 2 sp|Q9UBC3-2|DNM3B_HUMAN Isoform 2 of DNA (cytosine-5)-methyl 1.9e-15 59.3 0.0 7.1e-11 44.3 0.0 2.2 2 sp|Q9UBC3-6|DNM3B_HUMAN Isoform 6 of DNA (cytosine-5)-methyl 2e-15 59.2 0.0 4.4e-11 45.0 0.0 2.3 2 sp|Q9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3 3.1e-14 55.3 0.0 4.5e-14 54.8 0.0 1.2 1 tr|E7EMI8|E7EMI8_HUMAN tRNA (cytosine(38)-C(5))-methyltrans 5.7e-13 51.2 0.0 5.5e-11 44.7 0.0 2.2 2 sp|Q9UBC3-7|DNM3B_HUMAN Isoform 7 of DNA (cytosine-5)-methyl 6.7e-13 51.0 0.0 6e-11 44.5 0.0 2.2 2 sp|Q9UBC3-8|DNM3B_HUMAN Isoform 8 of DNA (cytosine-5)-methyl 7.4e-13 50.8 0.0 6.5e-11 44.4 0.0 2.2 2 sp|Q9UBC3-3|DNM3B_HUMAN Isoform 3 of DNA (cytosine-5)-methyl 1.8e-11 46.3 0.0 3e-11 45.6 0.0 1.3 1 tr|F8WE91|F8WE91_HUMAN DNA (cytosine-5)-methyltransferase 3 3.7e-11 45.2 0.0 5.9e-11 44.6 0.0 1.3 1 sp|Q9UBC3-4|DNM3B_HUMAN Isoform 4 of DNA (cytosine-5)-methyl 4.3e-11 45.0 0.0 6.8e-11 44.4 0.0 1.3 1 sp|Q9UBC3-5|DNM3B_HUMAN Isoform 5 of DNA (cytosine-5)-methyl 1.3e-10 43.4 0.0 7.5e-05 24.5 0.0 2.1 2 tr|H0Y2T8|H0Y2T8_HUMAN tRNA (cytosine(38)-C(5))-methyltrans 9.2e-07 30.8 0.0 0.0012 20.5 0.0 2.2 2 tr|B7Z8H2|B7Z8H2_HUMAN cDNA FLJ52038, highly similar to DNA 1.9e-05 26.4 0.0 2e-05 26.4 0.0 1.0 1 sp|O14717-5|TRDMT_HUMAN Isoform E of tRNA (cytosine(38)-C(5) 2.7e-05 25.9 0.0 3e-05 25.8 0.0 1.0 1 tr|Q7Z3E4|Q7Z3E4_HUMAN Putative uncharacterized protein DKF 5.6e-05 24.9 0.0 6e-05 24.8 0.0 1.0 1 sp|O14717-4|TRDMT_HUMAN Isoform D of tRNA (cytosine(38)-C(5) 0.00022 23.0 0.0 0.00026 22.7 0.0 1.2 1 sp|O14717-6|TRDMT_HUMAN Isoform F of tRNA (cytosine(38)-C(5) 0.00028 22.6 0.0 0.00032 22.4 0.0 1.1 1 tr|B0YJ06|B0YJ06_HUMAN tRNA (cytosine(38)-C(5))-methyltrans 0.0027 19.4 0.0 0.0044 18.7 0.0 1.3 1 tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS= 0.0036 19.0 0.0 0.0071 18.0 0.0 1.4 1 sp|Q9NRN9|METL5_HUMAN Methyltransferase-like protein 5 OS= 0.0036 19.0 0.0 0.0064 18.2 0.0 1.3 1 tr|B8ZZE3|B8ZZE3_HUMAN Methyltransferase like 5, isoform CR 0.0051 18.5 0.0 0.0097 17.6 0.0 1.4 1 tr|B8ZZC8|B8ZZC8_HUMAN Methyltransferase-like protein 5 OS= ------ inclusion threshold ------ 0.11 14.1 3.1 0.18 13.4 2.9 1.6 1 sp|Q6NXP0|EFC12_HUMAN EF-hand calcium-binding domain-conta 1.1 10.8 0.0 1.7 10.2 0.0 1.2 1 sp|Q53H54|TYW2_HUMAN tRNA wybutosine-synthesizing protein Domain annotation for each sequence (and alignments): >> sp|P26358-3|DNMT1_HUMAN Isoform 3 of DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens GN=DNMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 162.1 0.0 3.8e-50 1e-46 2 334 .. 804 1257 .. 803 1258 .. 0.74 Alignments for each domain: == domain 1 score: 162.1 bits; conditional E-value: 3.8e-50 EEEEES-TT-HHHHHHHHTT.-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-............GS--...-SEEEE- CS DNA_methylase 2 kfidLfaGiGGfrlgleaag.fecvaaseidkkaaktYeanfk..kvsigDitkidkk............klpe..diDlLvgG 68 +++d f+G+GG++ g+++ag ++ +a+e+++ aa+ ++ n++ v ++D + + k lp+ d+++L+gG sp|P26358-3|DNMT1_HUMAN 804 RTLDVFSGCGGLSEGFHQAGiSDTLWAIEMWDPAAQAFRLNNPgsTVFTEDCNILLKLvmagettnsrgqRLPQkgDVEMLCGG 887 789*****************999*********************745555555555446666777777779998667******* PP --GGGTECTSE..E--TTSGGGHHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-S CS DNA_methylase 69 fPCqpfSvaGk..qkgfedtrgtLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvp 150 +PCq+fS ++ + +++L + + + + ++P +fllENV++ ++ +++ +lk l l +GY++++ +l+a +yGv+ sp|P26358-3|DNMT1_HUMAN 888 PPCQGFSGMNRfnSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVA 971 *******887654666677777************************************************************** PP B--EEEEEEEEEGGG---...............-------SS---GGG..............TSGGGTTS-EEBTTTB--GGGS CS DNA_methylase 151 QnReRvfivgirkdleln...............vlvkvkefrfpkkkd.........leasktlrdlleekseldeektalsdk 210 Q R+R +i++ +++l ++v v +++f ++ ++++t+ dl+e + + + + sp|P26358-3|DNMT1_HUMAN 972 QTRRRAIILAAAPGEKLPlfpeplhvfapracqLSVVVDDKKFVSNITrlssgpfrtITVRDTMSDLPEVR-----NGASALEI 1050 *************9988888888877777776633333344443333356667655555555666665543.....22222222 PP SSTT-EE--.......S---HHHTS--.................................B--TTS...-B----S-STT-... CS DNA_methylase 211 lvekeekikkttkaseegypkelsrnr.................................idkveelkglsatrrksgrge... 258 ++ e +++ +++ + +y+ + r+ + ++ ++++l+ t+++ ++g+ sp|P26358-3|DNMT1_HUMAN 1051 SYNGEPQSWFQRQLRGAQYQ-PILRDHickdmsalvaarmrhiplapgsdwrdlpnievrLSDGTMARKLRYTHHDRKNGRsss 1133 33333333333333333444.222222344446666777889999999999999999888444444455555555544444556 PP ....................................................-B-TTS---EEEETTEEE--T.TTGGG--B-B CS DNA_methylase 259 ....................................................klekelaeagklqknkerfkpviekkriRrLt 290 ++ +++ ++++k+++ v++++++R + sp|P26358-3|DNMT1_HUMAN 1134 galrgvcscveagkacdpaarqfntlipwclphtgnrhnhwaglygrlewdgFFSTTVTNPEPMGKQGR----VLHPEQHRVVS 1213 667777777788888887777777777777777777767777666666665555556666666666666....9********** PP HHHHHHHHT--TT-----SBHHHHHHHHTS--HHHHHHHHHHHH CS DNA_methylase 291 prEaarlqGfPddfefgskksaaykqiGnsVpvpvieaiakeik 334 +rE+ar qGfPd++ + ++ ++ +q+Gn+Vp+p+++ai+ eik sp|P26358-3|DNMT1_HUMAN 1214 VRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIK 1257 ***************************************99986 PP >> sp|P26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens GN=DNMT1 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 161.5 0.0 6.1e-50 1.6e-46 2 334 .. 1140 1593 .. 1139 1594 .. 0.74 Alignments for each domain: == domain 1 score: 161.5 bits; conditional E-value: 6.1e-50 EEEEES-TT-HHHHHHHHTT.-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-............GS--...-SEEEE--- CS DNA_methylase 2 kfidLfaGiGGfrlgleaag.fecvaaseidkkaaktYeanfk..kvsigDitkidkk............klpe..diDlLvgGfP 70 +++d f+G+GG++ g+++ag ++ +a+e+++ aa+ ++ n++ v ++D + + k lp+ d+++L+gG+P sp|P26358|DNMT1_HUMAN 1140 RTLDVFSGCGGLSEGFHQAGiSDTLWAIEMWDPAAQAFRLNNPgsTVFTEDCNILLKLvmagettnsrgqRLPQkgDVEMLCGGPP 1225 789*****************999*********************745555555555446666777777779998667********* PP GGGTECTSE..E--TTSGGGHHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB--E CS DNA_methylase 71 CqpfSvaGk..qkgfedtrgtLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQnRe 154 Cq+fS ++ + +++L + + + + ++P +fllENV++ ++ +++ +lk l l +GY++++ +l+a +yGv+Q R+ sp|P26358|DNMT1_HUMAN 1226 CQGFSGMNRfnSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRR 1311 *****887654666677777****************************************************************** PP EEEEEEEEGGG---...............-------SS---GGG..............TSGGGTTS-EEBTTTB--GGGSSSTT-E CS DNA_methylase 155 Rvfivgirkdleln...............vlvkvkefrfpkkkd.........leasktlrdlleekseldeektalsdklvekee 216 R +i++ +++l ++v v +++f ++ ++++t+ dl+e + + + + ++ e sp|P26358|DNMT1_HUMAN 1312 RAIILAAAPGEKLPlfpeplhvfapracqLSVVVDDKKFVSNITrlssgpfrtITVRDTMSDLPEVR-----NGASALEISYNGEP 1392 *********9988888888877777776633333344443333356667655555555666665543.....22222222333333 PP E--.......S---HHHTS--.................................B--TTS...-B----S-STT-........... CS DNA_methylase 217 kikkttkaseegypkelsrnr.................................idkveelkglsatrrksgrge........... 258 +++ +++ + +y+ + r+ + ++ ++++l+ t+++ ++g+ sp|P26358|DNMT1_HUMAN 1393 QSWFQRQLRGAQYQ-PILRDHickdmsalvaarmrhiplapgsdwrdlpnievrLSDGTMARKLRYTHHDRKNGRsssgalrgvcs 1477 33333333333444.22222234444666677788999999999999999988844444445555555554444455666777777 PP ............................................-B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT- CS DNA_methylase 259 ............................................klekelaeagklqknkerfkpviekkriRrLtprEaarlqGf 300 ++ +++ ++++k+++ v++++++R ++rE+ar qGf sp|P26358|DNMT1_HUMAN 1478 cveagkacdpaarqfntlipwclphtgnrhnhwaglygrlewdgFFSTTVTNPEPMGKQGR----VLHPEQHRVVSVRECARSQGF 1559 7788888887777777777777777777767777666666665555556666666666666....9******************** PP -TT-----SBHHHHHHHHTS--HHHHHHHHHHHH CS DNA_methylase 301 PddfefgskksaaykqiGnsVpvpvieaiakeik 334 Pd++ + ++ ++ +q+Gn+Vp+p+++ai+ eik sp|P26358|DNMT1_HUMAN 1560 PDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIK 1593 *****************************99986 PP >> sp|P26358-2|DNMT1_HUMAN Isoform 2 of DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens GN=DNMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 161.4 0.0 6.2e-50 1.7e-46 2 334 .. 1156 1609 .. 1155 1610 .. 0.74 Alignments for each domain: == domain 1 score: 161.4 bits; conditional E-value: 6.2e-50 EEEEES-TT-HHHHHHHHTT.-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-............GS--...-SEEEE- CS DNA_methylase 2 kfidLfaGiGGfrlgleaag.fecvaaseidkkaaktYeanfk..kvsigDitkidkk............klpe..diDlLvgG 68 +++d f+G+GG++ g+++ag ++ +a+e+++ aa+ ++ n++ v ++D + + k lp+ d+++L+gG sp|P26358-2|DNMT1_HUMAN 1156 RTLDVFSGCGGLSEGFHQAGiSDTLWAIEMWDPAAQAFRLNNPgsTVFTEDCNILLKLvmagettnsrgqRLPQkgDVEMLCGG 1239 789*****************999*********************745555555555446666777777779998667******* PP --GGGTECTSE..E--TTSGGGHHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-S CS DNA_methylase 69 fPCqpfSvaGk..qkgfedtrgtLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvp 150 +PCq+fS ++ + +++L + + + + ++P +fllENV++ ++ +++ +lk l l +GY++++ +l+a +yGv+ sp|P26358-2|DNMT1_HUMAN 1240 PPCQGFSGMNRfnSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVA 1323 *******887654666677777************************************************************** PP B--EEEEEEEEEGGG---...............-------SS---GGG..............TSGGGTTS-EEBTTTB--GGGS CS DNA_methylase 151 QnReRvfivgirkdleln...............vlvkvkefrfpkkkd.........leasktlrdlleekseldeektalsdk 210 Q R+R +i++ +++l ++v v +++f ++ ++++t+ dl+e + + + + sp|P26358-2|DNMT1_HUMAN 1324 QTRRRAIILAAAPGEKLPlfpeplhvfapracqLSVVVDDKKFVSNITrlssgpfrtITVRDTMSDLPEVR-----NGASALEI 1402 *************9988888888877777776633333344443333356667655555555666665543.....22222222 PP SSTT-EE--.......S---HHHTS--.................................B--TTS...-B----S-STT-... CS DNA_methylase 211 lvekeekikkttkaseegypkelsrnr.................................idkveelkglsatrrksgrge... 258 ++ e +++ +++ + +y+ + r+ + ++ ++++l+ t+++ ++g+ sp|P26358-2|DNMT1_HUMAN 1403 SYNGEPQSWFQRQLRGAQYQ-PILRDHickdmsalvaarmrhiplapgsdwrdlpnievrLSDGTMARKLRYTHHDRKNGRsss 1485 33333333333333333444.222222344446666777889999999999999999888444444455555555544444556 PP ....................................................-B-TTS---EEEETTEEE--T.TTGGG--B-B CS DNA_methylase 259 ....................................................klekelaeagklqknkerfkpviekkriRrLt 290 ++ +++ ++++k+++ v++++++R + sp|P26358-2|DNMT1_HUMAN 1486 galrgvcscveagkacdpaarqfntlipwclphtgnrhnhwaglygrlewdgFFSTTVTNPEPMGKQGR----VLHPEQHRVVS 1565 667777777788888887777777777777777777767777666666665555556666666666666....9********** PP HHHHHHHHT--TT-----SBHHHHHHHHTS--HHHHHHHHHHHH CS DNA_methylase 291 prEaarlqGfPddfefgskksaaykqiGnsVpvpvieaiakeik 334 +rE+ar qGfPd++ + ++ ++ +q+Gn+Vp+p+++ai+ eik sp|P26358-2|DNMT1_HUMAN 1566 VRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIK 1609 ***************************************99986 PP >> tr|F5GX68|F5GX68_HUMAN Cytosine-specific methyltransferase OS=Homo sapiens GN=DNMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 161.1 0.0 7.6e-50 2e-46 2 334 .. 1140 1596 .. 1139 1597 .. 0.75 Alignments for each domain: == domain 1 score: 161.1 bits; conditional E-value: 7.6e-50 EEEEES-TT-HHHHHHHHTT.-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-............GS--...-SEEEE-- CS DNA_methylase 2 kfidLfaGiGGfrlgleaag.fecvaaseidkkaaktYeanfk..kvsigDitkidkk............klpe..diDlLvgGf 69 +++d f+G+GG++ g+++ag ++ +a+e+++ aa+ ++ n++ v ++D + + k lp+ d+++L+gG+ tr|F5GX68|F5GX68_HUMAN 1140 RTLDVFSGCGGLSEGFHQAGiSDTLWAIEMWDPAAQAFRLNNPgsTVFTEDCNILLKLvmagettnsrgqRLPQkgDVEMLCGGP 1224 789*****************999*********************745555555555446666777777779998667******** PP -GGGTECTSE..E--TTSGGGHHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB- CS DNA_methylase 70 PCqpfSvaGk..qkgfedtrgtLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQn 152 PCq+fS ++ + +++L + + + + ++P +fllENV++ ++ +++ +lk l l +GY++++ +l+a +yGv+Q tr|F5GX68|F5GX68_HUMAN 1225 PCQGFSGMNRfnSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQT 1309 ******887654666677777**************************************************************** PP -EEEEEEEEEGGG---...............-------SS---GGG..............TSGGGTTS-EEBTTTB--GGGSSST CS DNA_methylase 153 ReRvfivgirkdleln...............vlvkvkefrfpkkkd.........leasktlrdlleekseldeektalsdklve 213 R+R +i++ +++l ++v v +++f ++ ++++t+ dl+e + + + + ++ tr|F5GX68|F5GX68_HUMAN 1310 RRRAIILAAAPGEKLPlfpeplhvfapracqLSVVVDDKKFVSNITrlssgpfrtITVRDTMSDLPEVR-----NGASALEISYN 1389 ***********9988888888877777776633333344443333356667655555555666665543.....22222222333 PP T-EE--.......S---HHHTS--.................................B--TTS...-B----S-STT-....... CS DNA_methylase 214 keekikkttkaseegypkelsrnr.................................idkveelkglsatrrksgrge....... 258 e +++ +++ + +y+ + r+ + ++ ++++l+ t+++ ++g+ tr|F5GX68|F5GX68_HUMAN 1390 GEPQSWFQRQLRGAQYQ-PILRDHickdmsalvaarmrhiplapgsdwrdlpnievrLSDGTMARKLRYTHHDRKNGRsssgalr 1473 33333333333333444.2222223444466667778899999999999999998884444444555555555544445566678 PP ...................................................-B-TTS---EEEETTEEE--T.TTGGG--B-BHH CS DNA_methylase 259 ...................................................klekelaeagklqknkerfkpviekkriRrLtpr 292 ++ +++ ++++k+++ v++++++R ++r tr|F5GX68|F5GX68_HUMAN 1474 gvcscveggssgkacdpaarqfntlipwclphtgnrhnhwaglygrlewdgFFSTTVTNPEPMGKQGR----VLHPEQHRVVSVR 1554 88888888888888888888777777777777777777777777766666555566666666666666....9************ PP HHHHHHT--TT-----SBHHHHHHHHTS--HHHHHHHHHHHH CS DNA_methylase 293 EaarlqGfPddfefgskksaaykqiGnsVpvpvieaiakeik 334 E+ar qGfPd++ + ++ ++ +q+Gn+Vp+p+++ai+ eik tr|F5GX68|F5GX68_HUMAN 1555 ECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIK 1596 *************************************99986 PP >> sp|O14717|TRDMT_HUMAN tRNA (cytosine(38)-C(5))-methyltransferase OS=Homo sapiens GN=TRDMT1 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 143.9 0.0 1.3e-44 3.5e-41 2 332 .. 5 388 .. 4 391 .] 0.74 Alignments for each domain: == domain 1 score: 143.9 bits; conditional E-value: 1.3e-44 EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--..-SEEEE---GGGTECTSEE--TT CS DNA_methylase 2 kfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.diDlLvgGfPCqpfSvaGkqkgfe 84 ++++L +G+GG++++l++ ++vaa++ + a ++Y+ nf+ + + i+ i+ +++ ++D+++ ++PCqpf G q ++ sp|O14717|TRDMT_HUMAN 5 RVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPhtQLLAKTIEGITLEEFDRlSFDMILMSPPCQPFTRIGRQGDMT 92 899***************99999*********************777777778888888999999*********************** PP SGGGHHHHHHHHHHHHH-..-SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB--EEEEEEEEEGGG---.. CS DNA_methylase 85 dtrgtLffeiiriikekk..PkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQnReRvfivgirkdleln.. 168 d r + f i i+ + Pk++llENVkg + t + ++++ e++G++++ ll G+p +R R f+++ +++++l sp|O14717|TRDMT_HUMAN 93 DSRTNSFLHILDILPRLQklPKYILLENVKGFEVS---STRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPfq 177 **************998888***********9888...567889***************************************99999 PP ......-------SS---GGG.....TSGGGTTS-EE.....BTTTB--GGGSSSTT-EE--.......S---H..HHTS--...... CS DNA_methylase 169 ......vlvkvkefrfpkkkdleasktlrdlleekse.....ldeektalsdklvekeekikkttkaseegypk..elsrnr...... 237 ++++ e+ +p+k+ ++ ++++e+++e + + + +d+++ k e+ ++ + +++++ + + + sp|O14717|TRDMT_HUMAN 178 apgqvlMEFPKIESVHPQKYA---MDVENKIQEKNVEpnisfDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLsvK----Mlkdfle 258 999977666666666666654...33444444443333344433334444444444444444333333333331222....1344467 PP ....................................B--TTS...-B----S-STT-.....-B-TTS---EEEETTEEE--T.TTGG CS DNA_methylase 238 ....................................idkveelkglsatrrksgrge.....klekelaeagklqknkerfkpviekk 284 + g+ ++++ +g+ + ++++++ ++ +++e+ + sp|O14717|TRDMT_HUMAN 259 ddtdvnqyllppksllryallldivqptcrrsvcftK-------GYGSYIEGTGSVLqtaedVQVENIYKSLTNLSQEEQIT-KLLIL 338 7778888888888888888888888888855444333.......44444444443223322222333333333333333333.35556 PP G--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHHH CS DNA_methylase 285 riRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiake 332 + R +tp+E a l GfP +f f++k + ++y+++Gns++v v+ +++k sp|O14717|TRDMT_HUMAN 339 KLRYFTPKEIANLLGFPPEFGFPEKITvkQRYRLLGNSLNVHVVAKLIKI 388 78*******************************************99985 PP >> sp|O14717-2|TRDMT_HUMAN Isoform B of tRNA (cytosine(38)-C(5))-methyltransferase OS=Homo sapiens GN=TRDMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 44.1 0.0 3.1e-14 8.2e-11 2 74 .. 5 82 .. 4 87 .. 0.91 2 ! 72.1 0.0 9e-23 2.4e-19 101 332 .. 87 364 .. 83 367 .] 0.67 Alignments for each domain: == domain 1 score: 44.1 bits; conditional E-value: 3.1e-14 EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--..-SEEEE---GGGT CS DNA_methylase 2 kfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.diDlLvgGfPCqpf 74 ++++L +G+GG++++l++ ++vaa++ + a ++Y+ nf+ + + i+ i+ +++ ++D+++ ++PCqpf sp|O14717-2|TRDMT_HUMAN 5 RVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPhtQLLAKTIEGITLEEFDRlSFDMILMSPPCQPF 82 899***************99999*********************777777778888888999999************9 PP == domain 2 score: 72.1 bits; conditional E-value: 9e-23 H--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB--EEEEEEEEEGGG---........-------SS- CS DNA_methylase 101 kkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQnReRvfivgirkdleln........vlvkvkefrf 178 k Pk++llENVkg + t + ++++ e++G++++ ll G+p +R R f+++ +++++l ++++ e+ + sp|O14717-2|TRDMT_HUMAN 87 KLPKYILLENVKGFEVS---STRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPfqapgqvlMEFPKIESVH 169 66***********9888...567889***************************************999999999776666666666 PP --GGG.....TSGGGTTS-EE.....BTTTB--GGGSSSTT-EE--.......S---H..HHTS--.................... CS DNA_methylase 179 pkkkdleasktlrdlleekse.....ldeektalsdklvekeekikkttkaseegypk..elsrnr.................... 237 p+k+ ++ ++++e+++e + + + +d+++ k e+ ++ + +++++ + + + sp|O14717-2|TRDMT_HUMAN 170 PQKYA---MDVENKIQEKNVEpnisfDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLsvK----Mlkdfleddtdvnqyllppks 248 66654...33444444443333344433334444444444444444333333333331222....134446777788888888888 PP ......................B--TTS...-B----S-STT-.....-B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHH CS DNA_methylase 238 ......................idkveelkglsatrrksgrge.....klekelaeagklqknkerfkpviekkriRrLtprEaar 296 + g+ ++++ +g+ + ++++++ ++ +++e+ + + R +tp+E a sp|O14717-2|TRDMT_HUMAN 249 llryallldivqptcrrsvcftK-------GYGSYIEGTGSVLqtaedVQVENIYKSLTNLSQEEQIT-KLLILKLRYFTPKEIAN 326 88888888888888855444333.......44444444443223322222333333333333333333.3555678********** PP HHT--TT-----SBH..HHHHHHHTS--HHHHHHHHHH CS DNA_methylase 297 lqGfPddfefgskks..aaykqiGnsVpvpvieaiake 332 l GfP +f f++k + ++y+++Gns++v v+ +++k sp|O14717-2|TRDMT_HUMAN 327 LLGFPPEFGFPEKITvkQRYRLLGNSLNVHVVAKLIKI 364 *********************************99985 PP >> sp|O14717-3|TRDMT_HUMAN Isoform C of tRNA (cytosine(38)-C(5))-methyltransferase OS=Homo sapiens GN=TRDMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 44.1 0.0 3.2e-14 8.4e-11 2 74 .. 5 82 .. 4 85 .. 0.92 2 ! 54.6 0.0 2e-17 5.3e-14 126 332 .. 87 342 .. 83 345 .] 0.65 Alignments for each domain: == domain 1 score: 44.1 bits; conditional E-value: 3.2e-14 EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--..-SEEEE---GGGT CS DNA_methylase 2 kfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.diDlLvgGfPCqpf 74 ++++L +G+GG++++l++ ++vaa++ + a ++Y+ nf+ + + i+ i+ +++ ++D+++ ++PCqpf sp|O14717-3|TRDMT_HUMAN 5 RVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPhtQLLAKTIEGITLEEFDRlSFDMILMSPPCQPF 82 899***************99999*********************777777778888888999999************9 PP == domain 2 score: 54.6 bits; conditional E-value: 2e-17 HHHHHHHHTEEEEEEEEEGGGTT-SB--EEEEEEEEEGGG---........-------SS---GGG.....TSGGGTTS-EE.... CS DNA_methylase 126 ilekleelGYevsykllnasdyGvpQnReRvfivgirkdleln........vlvkvkefrfpkkkdleasktlrdlleekse.... 199 ++++ e++G++++ ll G+p +R R f+++ +++++l ++++ e+ +p+k+ ++ ++++e+++e sp|O14717-3|TRDMT_HUMAN 87 LIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPfqapgqvlMEFPKIESVHPQKYA---MDVENKIQEKNVEpnis 169 689*************************************99999999977666666666666654...33444444443333344 PP .BTTTB--GGGSSSTT-EE--.......S---H..HHTS--..........................................B-- CS DNA_methylase 200 .ldeektalsdklvekeekikkttkaseegypk..elsrnr..........................................idk 240 + + + +d+++ k e+ ++ + +++++ + + + + sp|O14717-3|TRDMT_HUMAN 170 fDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLsvK----MlkdfleddtdvnqyllppksllryallldivqptcrrsvcftK-- 249 433334444444444444444333333333331222....13444677778888888888888888888888888855444333.. PP TTS...-B----S-STT-.....-B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHT CS DNA_methylase 241 veelkglsatrrksgrge.....klekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGn 319 g+ ++++ +g+ + ++++++ ++ +++e+ + + R +tp+E a l GfP +f f++k + ++y+++Gn sp|O14717-3|TRDMT_HUMAN 250 -----GYGSYIEGTGSVLqtaedVQVENIYKSLTNLSQEEQIT-KLLILKLRYFTPKEIANLLGFPPEFGFPEKITvkQRYRLLGN 329 .....44444444443223322222333333333333333333.3555678*********************************** PP S--HHHHHHHHHH CS DNA_methylase 320 sVpvpvieaiake 332 s++v v+ +++k sp|O14717-3|TRDMT_HUMAN 330 SLNVHVVAKLIKI 342 ********99985 PP >> tr|K7ENW7|K7ENW7_HUMAN DNA (cytosine-5)-methyltransferase 1 (Fragment) OS=Homo sapiens GN=DNMT1 PE=3 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 86.9 0.0 2.9e-27 7.8e-24 71 319 .. 2 354 .. 2 359 .. 0.70 Alignments for each domain: == domain 1 score: 86.9 bits; conditional E-value: 2.9e-27 GGGTECTSE..E--TTSGGGHHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB--EE CS DNA_methylase 71 CqpfSvaGk..qkgfedtrgtLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQnReR 155 Cq+fS ++ + +++L + + + + ++P +fllENV++ ++ +++ +lk l l +GY++++ +l+a +yGv+Q R+R tr|K7ENW7|K7ENW7_HUMAN 2 CQGFSGMNRfnSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 88 99999777544566666777******************************************************************* PP EEEEEEEGGG---...............-------SS---GGG..............TSGGGTTS-EEBTTTB--GGGSSSTT-EE- CS DNA_methylase 156 vfivgirkdleln...............vlvkvkefrfpkkkd.........leasktlrdlleekseldeektalsdklvekeeki 218 +i++ +++l ++v v +++f ++ ++++t+ dl+e + + + + ++ e ++ tr|K7ENW7|K7ENW7_HUMAN 89 AIILAAAPGEKLPlfpeplhvfapracqLSVVVDDKKFVSNITrlssgpfrtITVRDTMSDLPEVR-----NGASALEISYNGEPQS 170 ********9988888888877777776633333344443333356667655555555666665543.....2222222233333333 PP -.......S---HHHTS--.................................B--TTS...-B----S-STT-.............. CS DNA_methylase 219 kkttkaseegypkelsrnr.................................idkveelkglsatrrksgrge.............. 258 + +++ + +y+ + r+ + ++ ++++l+ t+++ ++g+ tr|K7ENW7|K7ENW7_HUMAN 171 WFQRQLRGAQYQ-PILRDHickdmsalvaarmrhiplapgsdwrdlpnievrLSDGTMARKLRYTHHDRKNGRsssgalrgvcscve 256 333333333444.22222234444666677788999999999999999988844444445555555554444455666777777778 PP .........................................-B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT- CS DNA_methylase 259 .........................................klekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddf 304 ++ +++ ++++k+++ v++++++R ++rE+ar qGfPd++ tr|K7ENW7|K7ENW7_HUMAN 257 agkacdpaarqfntlipwclphtgnrhnhwaglygrlewdgFFSTTVTNPEPMGKQGR----VLHPEQHRVVSVRECARSQGFPDTY 339 8888887777777777777777777767777666666665555556666666666666....9************************ PP ----SBHHHHHHHHT CS DNA_methylase 305 efgskksaaykqiGn 319 + ++ ++ +q++ tr|K7ENW7|K7ENW7_HUMAN 340 RLFGNILDKHRQVSG 354 **9999988777755 PP >> sp|Q9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B OS=Homo sapiens GN=DNMT3B PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.0 0.1 1.6 4.4e+03 219 275 .. 349 404 .. 306 428 .. 0.73 2 ! 44.3 0.0 2.7e-14 7.2e-11 1 120 [. 575 708 .. 575 725 .. 0.84 3 ! 12.9 0.0 9.4e-05 0.25 258 331 .. 769 844 .. 727 848 .. 0.77 Alignments for each domain: == domain 1 score: -1.0 bits; conditional E-value: 1.6 -.......S---HHHTS--B--TTS...-B----S-STT--B-TTS---EEEETTEE CS DNA_methylase 219 kkttkaseegypkelsrnridkveelkglsatrrksgrgeklekelaeagklqknke 275 k++++++ + + ++ r +k e+ k++++trr++ ++ ++++ ++ +l n + sp|Q9UBC3|DNM3B_HUMAN 349 KPNNTQPVVNKS-KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCY 404 455555555566.67777789999999999999999988766666666555555544 PP == domain 2 score: 44.3 bits; conditional E-value: 2.7e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.EE- CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.kqk 81 +++++Lf+Gi l l++ g + ++ase ++ +++ +++ + +D+++i+kk+++e +Dl++gG PC++ S ++k sp|Q9UBC3|DNM3B_HUMAN 575 IRVLSLFDGIATGYLVLKELGikVGKYVASEVCEESIAVGTVKHEgnIKYVNDVRNITKKNIEEwGpFDLVIGGSPCNDLSNVNpARK 662 5899*****************887778999999997777777776669999*********9998647**************87626** PP -TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 82 gfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 g + g Lffe+ +++ + P + ++ENV ++ dk+ sp|Q9UBC3|DNM3B_HUMAN 663 GLYEGTGRLFFEFYHLLNYSRpkegddrPFFWMFENVVAMKVGDKR 708 ******************9995555555668899999988776665 PP == domain 3 score: 12.9 bits; conditional E-value: 9.4e-05 --B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS DNA_methylase 258 eklekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331 +k+++ ++++++ + k++ pv+ + ++ L E+ r+ GfP ++ s+ a+ k++G s +vpvi++++ sp|Q9UBC3|DNM3B_HUMAN 769 KKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 844 25556666666666666666679999*********************999888888*****************986 PP >> sp|Q9Y6K1-2|DNM3A_HUMAN Isoform 2 of DNA (cytosine-5)-methyltransferase 3A OS=Homo sapiens GN=DNMT3A # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 45.5 0.0 1.1e-14 3e-11 1 120 [. 445 578 .. 445 588 .. 0.88 2 ! 12.5 0.0 0.00012 0.33 261 332 .. 642 715 .. 594 718 .. 0.76 Alignments for each domain: == domain 1 score: 45.5 bits; conditional E-value: 1.1e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.E CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.k 79 +++++Lf+Gi l l+ g ++ ++ase ++ +++ +++ + gD++ +++k ++e +Dl++gG PC++ S+ + sp|Q9Y6K1-2|DNM3A_HUMAN 445 IRVLSLFDGIATGLLVLKDLGiqVDRYIASEVCEDSITVGMVRHQgkIMYVGDVRSVTQKHIQEwGpFDLVIGGSPCNDLSIVNpA 530 5899*****************99999*********999999999988999**********9998647**************98736 PP E--TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 80 qkgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 +kg + g Lffe+ r++ + + P + l+ENV + +dk+ sp|Q9Y6K1-2|DNM3A_HUMAN 531 RKGLYEGTGRLFFEFYRLLHDARpkegddrPFFWLFENVVAMGVSDKR 578 *********************995555555568899999888777664 PP == domain 2 score: 12.5 bits; conditional E-value: 0.00012 -TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHHH CS DNA_methylase 261 ekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiake 332 ++ ++++++ + k + pv ++++ L E+ r+ GfP ++ s+ s a+ +++G s +vpvi++++ sp|Q9Y6K1-2|DNM3A_HUMAN 642 RTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSrlARQRLLGRSWSVPVIRHLFAP 715 333333333333333334588999999999***************999999889999*************9875 PP >> sp|Q9UBC3-2|DNM3B_HUMAN Isoform 2 of DNA (cytosine-5)-methyltransferase 3B OS=Homo sapiens GN=DNMT3B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 44.3 0.0 2.6e-14 7e-11 1 120 [. 555 688 .. 555 705 .. 0.84 2 ! 13.0 0.0 9.1e-05 0.24 258 331 .. 749 824 .. 707 828 .. 0.77 Alignments for each domain: == domain 1 score: 44.3 bits; conditional E-value: 2.6e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.E CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.k 79 +++++Lf+Gi l l++ g + ++ase ++ +++ +++ + +D+++i+kk+++e +Dl++gG PC++ S + sp|Q9UBC3-2|DNM3B_HUMAN 555 IRVLSLFDGIATGYLVLKELGikVGKYVASEVCEESIAVGTVKHEgnIKYVNDVRNITKKNIEEwGpFDLVIGGSPCNDLSNVNpA 640 5899*****************887778999999997777777776669999*********9998647**************87626 PP E--TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 80 qkgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 +kg + g Lffe+ +++ + P + ++ENV ++ dk+ sp|Q9UBC3-2|DNM3B_HUMAN 641 RKGLYEGTGRLFFEFYHLLNYSRpkegddrPFFWMFENVVAMKVGDKR 688 ********************9995555555668899999988776665 PP == domain 2 score: 13.0 bits; conditional E-value: 9.1e-05 --B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS DNA_methylase 258 eklekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331 +k+++ ++++++ + k++ pv+ + ++ L E+ r+ GfP ++ s+ a+ k++G s +vpvi++++ sp|Q9UBC3-2|DNM3B_HUMAN 749 KKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 824 25556666666666666666679999*********************999888888*****************986 PP >> sp|Q9UBC3-6|DNM3B_HUMAN Isoform 6 of DNA (cytosine-5)-methyltransferase 3B OS=Homo sapiens GN=DNMT3B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 44.3 0.0 2.7e-14 7.1e-11 1 120 [. 567 700 .. 567 717 .. 0.84 2 ! 12.9 0.0 9.3e-05 0.25 258 331 .. 761 836 .. 719 840 .. 0.77 Alignments for each domain: == domain 1 score: 44.3 bits; conditional E-value: 2.7e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.E CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.k 79 +++++Lf+Gi l l++ g + ++ase ++ +++ +++ + +D+++i+kk+++e +Dl++gG PC++ S + sp|Q9UBC3-6|DNM3B_HUMAN 567 IRVLSLFDGIATGYLVLKELGikVGKYVASEVCEESIAVGTVKHEgnIKYVNDVRNITKKNIEEwGpFDLVIGGSPCNDLSNVNpA 652 5899*****************887778999999997777777776669999*********9998647**************87626 PP E--TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 80 qkgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 +kg + g Lffe+ +++ + P + ++ENV ++ dk+ sp|Q9UBC3-6|DNM3B_HUMAN 653 RKGLYEGTGRLFFEFYHLLNYSRpkegddrPFFWMFENVVAMKVGDKR 700 ********************9995555555668899999988776665 PP == domain 2 score: 12.9 bits; conditional E-value: 9.3e-05 --B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS DNA_methylase 258 eklekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331 +k+++ ++++++ + k++ pv+ + ++ L E+ r+ GfP ++ s+ a+ k++G s +vpvi++++ sp|Q9UBC3-6|DNM3B_HUMAN 761 KKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 836 25556666666666666666679999*********************999888888*****************986 PP >> sp|Q9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A OS=Homo sapiens GN=DNMT3A PE=1 SV=4 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 45.0 0.0 1.6e-14 4.4e-11 1 120 [. 634 767 .. 634 776 .. 0.88 2 ! 12.0 0.0 0.00017 0.46 262 332 .. 832 904 .. 784 907 .. 0.76 Alignments for each domain: == domain 1 score: 45.0 bits; conditional E-value: 1.6e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.EE- CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.kqk 81 +++++Lf+Gi l l+ g ++ ++ase ++ +++ +++ + gD++ +++k ++e +Dl++gG PC++ S+ ++k sp|Q9Y6K1|DNM3A_HUMAN 634 IRVLSLFDGIATGLLVLKDLGiqVDRYIASEVCEDSITVGMVRHQgkIMYVGDVRSVTQKHIQEwGpFDLVIGGSPCNDLSIVNpARK 721 5899*****************99999*********999999999988999**********9998647**************98736** PP -TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 82 gfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 g + g Lffe+ r++ + + P + l+ENV + +dk+ sp|Q9Y6K1|DNM3A_HUMAN 722 GLYEGTGRLFFEFYRLLHDARpkegddrPFFWLFENVVAMGVSDKR 767 *******************995555555568899999888776664 PP == domain 2 score: 12.0 bits; conditional E-value: 0.00017 TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHHH CS DNA_methylase 262 kelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiake 332 + ++++++ + k + pv ++++ L E+ r+ GfP ++ s+ s a+ +++G s +vpvi++++ sp|Q9Y6K1|DNM3A_HUMAN 832 TITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSrlARQRLLGRSWSVPVIRHLFAP 904 33333333333333334588899999999***************999999889999*************9875 PP >> tr|E7EMI8|E7EMI8_HUMAN tRNA (cytosine(38)-C(5))-methyltransferase OS=Homo sapiens GN=TRDMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 54.8 0.0 1.7e-17 4.5e-14 126 332 .. 52 307 .. 49 310 .] 0.65 Alignments for each domain: == domain 1 score: 54.8 bits; conditional E-value: 1.7e-17 HHHHHHHHTEEEEEEEEEGGGTT-SB--EEEEEEEEEGGG---........-------SS---GGG.....TSGGGTTS-EE..... CS DNA_methylase 126 ilekleelGYevsykllnasdyGvpQnReRvfivgirkdleln........vlvkvkefrfpkkkdleasktlrdlleekse..... 199 ++++ e++G++++ ll G+p +R R f+++ +++++l ++++ e+ +p+k+ ++ ++++e+++e tr|E7EMI8|E7EMI8_HUMAN 52 LIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPfqapgqvlMEFPKIESVHPQKYA---MDVENKIQEKNVEpnisf 135 5899************************************99999999977666666666666654...334444444433333444 PP BTTTB--GGGSSSTT-EE--.......S---H..HHTS--..........................................B--TT CS DNA_methylase 200 ldeektalsdklvekeekikkttkaseegypk..elsrnr..........................................idkve 242 + + + +d+++ k e+ ++ + +++++ + + + + tr|E7EMI8|E7EMI8_HUMAN 136 DGSIQCSGKDAILFKLETAEEIHRKNQQDSDLsvK----MlkdfleddtdvnqyllppksllryallldivqptcrrsvcftK---- 214 33334444444444444444333333333331222....13444677778888888888888888888888888855444333.... PP S...-B----S-STT-.....-B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS-- CS DNA_methylase 243 elkglsatrrksgrge.....klekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVp 322 g+ ++++ +g+ + ++++++ ++ +++e+ + + R +tp+E a l GfP +f f++k + ++y+++Gns++ tr|E7EMI8|E7EMI8_HUMAN 215 ---GYGSYIEGTGSVLqtaedVQVENIYKSLTNLSQEEQIT-KLLILKLRYFTPKEIANLLGFPPEFGFPEKITvkQRYRLLGNSLN 297 ...44444444443223322222333333333333333333.3555678************************************** PP HHHHHHHHHH CS DNA_methylase 323 vpvieaiake 332 v v+ +++k tr|E7EMI8|E7EMI8_HUMAN 298 VHVVAKLIKI 307 *****99985 PP >> sp|Q9UBC3-7|DNM3B_HUMAN Isoform 7 of DNA (cytosine-5)-methyltransferase 3B OS=Homo sapiens GN=DNMT3B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 44.7 0.0 2.1e-14 5.5e-11 1 120 [. 479 612 .. 479 627 .. 0.85 2 ? 4.3 0.0 0.039 1e+02 295 331 .. 647 685 .. 644 689 .. 0.89 Alignments for each domain: == domain 1 score: 44.7 bits; conditional E-value: 2.1e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.E CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.k 79 +++++Lf+Gi l l++ g + ++ase ++ +++ +++ + +D+++i+kk+++e +Dl++gG PC++ S + sp|Q9UBC3-7|DNM3B_HUMAN 479 IRVLSLFDGIATGYLVLKELGikVGKYVASEVCEESIAVGTVKHEgnIKYVNDVRNITKKNIEEwGpFDLVIGGSPCNDLSNVNpA 564 5899*****************887778999999997777777776669999*********9998647**************87626 PP E--TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 80 qkgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 +kg + g Lffe+ +++ + P + ++ENV ++ dk+ sp|Q9UBC3-7|DNM3B_HUMAN 565 RKGLYEGTGRLFFEFYHLLNYSRpkegddrPFFWMFENVVAMKVGDKR 612 ********************9995555555668899999888766665 PP == domain 2 score: 4.3 bits; conditional E-value: 0.039 HHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS DNA_methylase 295 arlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331 r+ GfP ++ s+ a+ k++G s +vpvi++++ sp|Q9UBC3-7|DNM3B_HUMAN 647 NRIFGFPVHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 685 69********998888888*****************986 PP >> sp|Q9UBC3-8|DNM3B_HUMAN Isoform 8 of DNA (cytosine-5)-methyltransferase 3B OS=Homo sapiens GN=DNMT3B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 44.5 0.0 2.2e-14 6e-11 1 120 [. 513 646 .. 513 661 .. 0.85 2 ? 4.2 0.0 0.041 1.1e+02 295 331 .. 681 719 .. 678 723 .. 0.89 Alignments for each domain: == domain 1 score: 44.5 bits; conditional E-value: 2.2e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.E CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.k 79 +++++Lf+Gi l l++ g + ++ase ++ +++ +++ + +D+++i+kk+++e +Dl++gG PC++ S + sp|Q9UBC3-8|DNM3B_HUMAN 513 IRVLSLFDGIATGYLVLKELGikVGKYVASEVCEESIAVGTVKHEgnIKYVNDVRNITKKNIEEwGpFDLVIGGSPCNDLSNVNpA 598 5899*****************887778999999997777777776669999*********9998647**************87626 PP E--TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 80 qkgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 +kg + g Lffe+ +++ + P + ++ENV ++ dk+ sp|Q9UBC3-8|DNM3B_HUMAN 599 RKGLYEGTGRLFFEFYHLLNYSRpkegddrPFFWMFENVVAMKVGDKR 646 ********************9995555555668899999888766665 PP == domain 2 score: 4.2 bits; conditional E-value: 0.041 HHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS DNA_methylase 295 arlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331 r+ GfP ++ s+ a+ k++G s +vpvi++++ sp|Q9UBC3-8|DNM3B_HUMAN 681 NRIFGFPVHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 719 69********998888888*****************986 PP >> sp|Q9UBC3-3|DNM3B_HUMAN Isoform 3 of DNA (cytosine-5)-methyltransferase 3B OS=Homo sapiens GN=DNMT3B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 44.4 0.0 2.4e-14 6.5e-11 1 120 [. 555 688 .. 555 703 .. 0.85 2 ? 4.1 0.0 0.044 1.2e+02 295 331 .. 723 761 .. 720 765 .. 0.89 Alignments for each domain: == domain 1 score: 44.4 bits; conditional E-value: 2.4e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.E CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.k 79 +++++Lf+Gi l l++ g + ++ase ++ +++ +++ + +D+++i+kk+++e +Dl++gG PC++ S + sp|Q9UBC3-3|DNM3B_HUMAN 555 IRVLSLFDGIATGYLVLKELGikVGKYVASEVCEESIAVGTVKHEgnIKYVNDVRNITKKNIEEwGpFDLVIGGSPCNDLSNVNpA 640 5899*****************887778999999997777777776669999*********9998647**************87626 PP E--TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 80 qkgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 +kg + g Lffe+ +++ + P + ++ENV ++ dk+ sp|Q9UBC3-3|DNM3B_HUMAN 641 RKGLYEGTGRLFFEFYHLLNYSRpkegddrPFFWMFENVVAMKVGDKR 688 ********************9995555555668899999888766665 PP == domain 2 score: 4.1 bits; conditional E-value: 0.044 HHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS DNA_methylase 295 arlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331 r+ GfP ++ s+ a+ k++G s +vpvi++++ sp|Q9UBC3-3|DNM3B_HUMAN 723 NRIFGFPVHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 761 69********998888888*****************986 PP >> tr|F8WE91|F8WE91_HUMAN DNA (cytosine-5)-methyltransferase 3A OS=Homo sapiens GN=DNMT3A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 45.6 0.0 1.1e-14 3e-11 1 120 [. 634 767 .. 634 780 .. 0.87 Alignments for each domain: == domain 1 score: 45.6 bits; conditional E-value: 1.1e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.EE CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.kq 80 +++++Lf+Gi l l+ g ++ ++ase ++ +++ +++ + gD++ +++k ++e +Dl++gG PC++ S+ ++ tr|F8WE91|F8WE91_HUMAN 634 IRVLSLFDGIATGLLVLKDLGiqVDRYIASEVCEDSITVGMVRHQgkIMYVGDVRSVTQKHIQEwGpFDLVIGGSPCNDLSIVNpAR 720 5899*****************99999*********999999999988999**********9998647**************98736* PP --TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 81 kgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 kg + g Lffe+ r++ + + P + l+ENV + +dk+ tr|F8WE91|F8WE91_HUMAN 721 KGLYEGTGRLFFEFYRLLHDARpkegddrPFFWLFENVVAMGVSDKR 767 ********************995555555568899999988777765 PP >> sp|Q9UBC3-4|DNM3B_HUMAN Isoform 4 of DNA (cytosine-5)-methyltransferase 3B OS=Homo sapiens GN=DNMT3B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 44.6 0.0 2.2e-14 5.9e-11 1 120 [. 555 688 .. 555 703 .. 0.85 Alignments for each domain: == domain 1 score: 44.6 bits; conditional E-value: 2.2e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.E CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.k 79 +++++Lf+Gi l l++ g + ++ase ++ +++ +++ + +D+++i+kk+++e +Dl++gG PC++ S + sp|Q9UBC3-4|DNM3B_HUMAN 555 IRVLSLFDGIATGYLVLKELGikVGKYVASEVCEESIAVGTVKHEgnIKYVNDVRNITKKNIEEwGpFDLVIGGSPCNDLSNVNpA 640 5899*****************887778999999997777777776669999*********9998647**************87626 PP E--TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 80 qkgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 +kg + g Lffe+ +++ + P + ++ENV ++ dk+ sp|Q9UBC3-4|DNM3B_HUMAN 641 RKGLYEGTGRLFFEFYHLLNYSRpkegddrPFFWMFENVVAMKVGDKR 688 ********************9995555555668899999888766665 PP >> sp|Q9UBC3-5|DNM3B_HUMAN Isoform 5 of DNA (cytosine-5)-methyltransferase 3B OS=Homo sapiens GN=DNMT3B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 44.4 0.0 2.5e-14 6.8e-11 1 120 [. 555 688 .. 555 703 .. 0.85 Alignments for each domain: == domain 1 score: 44.4 bits; conditional E-value: 2.5e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.E CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.k 79 +++++Lf+Gi l l++ g + ++ase ++ +++ +++ + +D+++i+kk+++e +Dl++gG PC++ S + sp|Q9UBC3-5|DNM3B_HUMAN 555 IRVLSLFDGIATGYLVLKELGikVGKYVASEVCEESIAVGTVKHEgnIKYVNDVRNITKKNIEEwGpFDLVIGGSPCNDLSNVNpA 640 5899*****************887778999999997777777776669999*********9998647**************87626 PP E--TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 80 qkgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 +kg + g Lffe+ +++ + P + ++ENV ++ dk+ sp|Q9UBC3-5|DNM3B_HUMAN 641 RKGLYEGTGRLFFEFYHLLNYSRpkegddrPFFWMFENVVAMKVGDKR 688 ********************9995555555668899999888766665 PP >> tr|H0Y2T8|H0Y2T8_HUMAN tRNA (cytosine(38)-C(5))-methyltransferase (Fragment) OS=Homo sapiens GN=TRDMT1 PE=3 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.5 0.0 2.8e-08 7.5e-05 23 74 .. 7 61 .. 4 64 .. 0.89 2 ! 17.3 0.0 4.3e-06 0.012 126 199 .. 66 144 .. 62 199 .. 0.69 Alignments for each domain: == domain 1 score: 24.5 bits; conditional E-value: 2.8e-08 EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--..-SEEEE---GGGT CS DNA_methylase 23 ecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.diDlLvgGfPCqpf 74 ++vaa++ + a ++Y+ nf+ + + i+ i+ +++ ++D+++ ++PCqpf tr|H0Y2T8|H0Y2T8_HUMAN 7 QVVAAIDVNTVANEVYKYNFPhtQLLAKTIEGITLEEFDRlSFDMILMSPPCQPF 61 6899*****************777777778888888999999************9 PP == domain 2 score: 17.3 bits; conditional E-value: 4.3e-06 HHHHHHHHTEEEEEEEEEGGGTT-SB--EEEEEEEEEGGG---........-------SS---GGG.....TSGGGTTS-EE CS DNA_methylase 126 ilekleelGYevsykllnasdyGvpQnReRvfivgirkdleln........vlvkvkefrfpkkkdleasktlrdlleekse 199 ++++ e++G++++ ll G+p +R R f+++ +++++l ++++ e+ +p+k+ ++ ++++e+++e tr|H0Y2T8|H0Y2T8_HUMAN 66 LIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPfqapgqvlMEFPKIESVHPQKYA---MDVENKIQEKNVE 144 689*************************************99899999977555555555555554...3333333333332 PP >> tr|B7Z8H2|B7Z8H2_HUMAN cDNA FLJ52038, highly similar to DNA (cytosine-5)-methyltransferase-like protein 2 OS=Homo sa # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 20.5 0.0 4.7e-07 0.0012 2 46 .. 5 51 .. 4 70 .. 0.87 2 ! 8.6 0.0 0.0019 5 272 305 .. 204 236 .. 65 245 .. 0.58 Alignments for each domain: == domain 1 score: 20.5 bits; conditional E-value: 4.7e-07 EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-.-SE CS DNA_methylase 2 kfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfkkvs 46 ++++L +G+GG++++l++ ++vaa++ + a ++Y+ nf+ ++ tr|B7Z8H2|B7Z8H2_HUMAN 5 RVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPHTQ 51 899***************99999********************8544 PP == domain 2 score: 8.6 bits; conditional E-value: 0.0019 TTEEE--T.TTGGG--B-BHHHHHHHHT--TT-- CS DNA_methylase 272 knkerfkpviekkriRrLtprEaarlqGfPddfe 305 +++e+ + + R +tp+E a l GfP +f tr|B7Z8H2|B7Z8H2_HUMAN 204 SQEEQIT-KLLILKLRYFTPKEIANLLGFPPEFG 236 2222222.24445679**************9996 PP >> sp|O14717-5|TRDMT_HUMAN Isoform E of tRNA (cytosine(38)-C(5))-methyltransferase OS=Homo sapiens GN=TRDMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 26.4 0.0 7.5e-09 2e-05 1 54 [. 4 63 .. 4 70 .. 0.82 Alignments for each domain: == domain 1 score: 26.4 bits; conditional E-value: 7.5e-09 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-.....-SEEEES-TTT CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk....kvsigDitkid 54 l++++L +G+GG++++l++ ++vaa++ + a ++Y+ nf+ ++ +itki+ sp|O14717-5|TRDMT_HUMAN 4 LRVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPhtqlLAKTIEITKIT 63 5899***************99999********************9764434444555544 PP >> tr|Q7Z3E4|Q7Z3E4_HUMAN Putative uncharacterized protein DKFZp686N1286 OS=Homo sapiens GN=DKFZp686N1286 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.8 0.0 1.1e-08 3e-05 1 54 [. 4 61 .. 4 68 .. 0.83 Alignments for each domain: == domain 1 score: 25.8 bits; conditional E-value: 1.1e-08 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTT CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkid 54 l++++L +G+GG++++l++ ++vaa++ + a ++Y+ nf+ + + i+k + tr|Q7Z3E4|Q7Z3E4_HUMAN 4 LRVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPhtQLLAKTIEKRS 61 589****************99999********************96544445555554 PP >> sp|O14717-4|TRDMT_HUMAN Isoform D of tRNA (cytosine(38)-C(5))-methyltransferase OS=Homo sapiens GN=TRDMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.8 0.0 2.2e-08 6e-05 1 46 [. 4 51 .. 4 60 .. 0.88 Alignments for each domain: == domain 1 score: 24.8 bits; conditional E-value: 2.2e-08 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-.-SE CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfkkvs 46 l++++L +G+GG++++l++ ++vaa++ + a ++Y+ nf+ ++ sp|O14717-4|TRDMT_HUMAN 4 LRVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPHTQ 51 589****************99999********************8443 PP >> sp|O14717-6|TRDMT_HUMAN Isoform F of tRNA (cytosine(38)-C(5))-methyltransferase OS=Homo sapiens GN=TRDMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.7 0.0 9.7e-08 0.00026 1 46 [. 4 51 .. 4 68 .. 0.89 Alignments for each domain: == domain 1 score: 22.7 bits; conditional E-value: 9.7e-08 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-.-SE CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfkkvs 46 l++++L +G+GG++++l++ ++vaa++ + a ++Y+ nf+ ++ sp|O14717-6|TRDMT_HUMAN 4 LRVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPHTQ 51 5899***************99999********************8443 PP >> tr|B0YJ06|B0YJ06_HUMAN tRNA (cytosine(38)-C(5))-methyltransferase OS=Homo sapiens GN=TRDMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.4 0.0 1.2e-07 0.00032 2 46 .. 5 51 .. 4 68 .. 0.89 Alignments for each domain: == domain 1 score: 22.4 bits; conditional E-value: 1.2e-07 EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-.-SE CS DNA_methylase 2 kfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfkkvs 46 ++++L +G+GG++++l++ ++vaa++ + a ++Y+ nf+ ++ tr|B0YJ06|B0YJ06_HUMAN 5 RVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPHTQ 51 899***************99999********************8443 PP >> tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.7 0.0 1.6e-06 0.0044 3 70 .. 55 128 .. 54 128 .. 0.84 Alignments for each domain: == domain 1 score: 18.7 bits; conditional E-value: 1.6e-06 EEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-.-SEEEES-TTTS-......GS--.-SEEEE--- CS DNA_methylase 3 fidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfkkvsigDitkidkk......klpediDlLvgGfP 70 + dL +G+G +++g ++ g ++ +id++a +++++n ++ ++ +i+ ++ + +++++D ++ +P tr|E7EMN2|E7EMN2_HUMAN 55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDvcllsnRMSKSFDTVIMNPP 128 579**************************************888888888777666666666656777776665 PP >> sp|Q9NRN9|METL5_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.0 0.0 2.7e-06 0.0071 3 70 .. 55 128 .. 54 129 .. 0.84 Alignments for each domain: == domain 1 score: 18.0 bits; conditional E-value: 2.7e-06 EEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-.-SEEEES-TTTS-......GS--.-SEEEE--- CS DNA_methylase 3 fidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfkkvsigDitkidkk......klpediDlLvgGfP 70 + dL +G+G +++g ++ g ++ +id++a +++++n ++ ++ +i+ ++ + +++++D ++ +P sp|Q9NRN9|METL5_HUMAN 55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDvcllsnRMSKSFDTVIMNPP 128 579**************************************888888887777666666666656777776665 PP >> tr|B8ZZE3|B8ZZE3_HUMAN Methyltransferase like 5, isoform CRA_b OS=Homo sapiens GN=METTL5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.2 0.0 2.4e-06 0.0064 3 70 .. 55 128 .. 54 129 .. 0.84 Alignments for each domain: == domain 1 score: 18.2 bits; conditional E-value: 2.4e-06 EEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-.-SEEEES-TTTS-......GS--.-SEEEE--- CS DNA_methylase 3 fidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfkkvsigDitkidkk......klpediDlLvgGfP 70 + dL +G+G +++g ++ g ++ +id++a +++++n ++ ++ +i+ ++ + +++++D ++ +P tr|B8ZZE3|B8ZZE3_HUMAN 55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDvcllsnRMSKSFDTVIMNPP 128 579**************************************888888887777666766666656777776665 PP >> tr|B8ZZC8|B8ZZC8_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.6 0.0 3.6e-06 0.0097 3 70 .. 55 128 .. 54 129 .. 0.84 Alignments for each domain: == domain 1 score: 17.6 bits; conditional E-value: 3.6e-06 EEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-.-SEEEES-TTTS-......GS--.-SEEEE--- CS DNA_methylase 3 fidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfkkvsigDitkidkk......klpediDlLvgGfP 70 + dL +G+G +++g ++ g ++ +id++a +++++n ++ ++ +i+ ++ + +++++D ++ +P tr|B8ZZC8|B8ZZC8_HUMAN 55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDvcllsnRMSKSFDTVIMNPP 128 579**************************************888888887777666666666656777776665 PP >> sp|Q6NXP0|EFC12_HUMAN EF-hand calcium-binding domain-containing protein 12 OS=Homo sapiens GN=EFCAB12 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.4 2.9 6.9e-05 0.18 144 259 .. 47 174 .. 41 333 .. 0.70 Alignments for each domain: == domain 1 score: 13.4 bits; conditional E-value: 6.9e-05 GGGTT-SB--EEEEEEEEEGGG----------SS---GGG......TSGGGTTS-EEBTTTB--GGGSSSTT-EE--.......S--- CS DNA_methylase 144 asdyGvpQnReRvfivgirkdlelnvlvkvkefrfpkkkd.leasktlrdlleekseldeektalsdklvekeekikkttkaseegyp 230 +d+ pQ R+R+++v ++d++ l++ ++ + p k + + + rd++e++ d + + +++ + +e ++ k+++e+ p sp|Q6NXP0|EFC12_HUMAN 47 QKDFRLPQTRRRIIMVPRKEDQTP--LNPASQPQAPPKPIpSFKVLEARDIQEQP--EDRKTWLSQRSKLRQELESFGDVKRWLENKP 130 589******************985..45555555554432334555667777776..5566666666666666666666777777777 PP H.........HHTS--B--TTS...-B----S-STT-........- CS DNA_methylase 231 k.........elsrnridkveelkglsatrrksgrge........k 259 + ++ +++ + + +at r++++++ + sp|Q6NXP0|EFC12_HUMAN 131 SitpseakvlHMIH--EEQSAQPNASQATTRTTRKKAprlsrlsrQ 174 54444444332222..244444455555555555433333333331 PP >> sp|Q53H54|TYW2_HUMAN tRNA wybutosine-synthesizing protein 2 homolog OS=Homo sapiens GN=TRMT12 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.2 0.0 0.00063 1.7 4 56 .. 239 300 .. 237 312 .. 0.74 Alignments for each domain: == domain 1 score: 10.2 bits; conditional E-value: 0.00063 EEES-TT-HHHHHH.HHTT-EEEEEEE--TTTHHHHHHH-.........-SEEEES-TTTS- CS DNA_methylase 4 idLfaGiGGfrlgl.eaagfecvaaseidkkaaktYeanfk........kvsigDitkidkk 56 +dL aGiG f+l + ag v a e++++a+ +++n + + ++gD +k++ + sp|Q53H54|TYW2_HUMAN 239 VDLYAGIGYFTLPFlVHAGAAFVHACEWNPHAVVALRNNLEingvadrcQIHFGDNRKLKLS 300 8***********8626788********************98777554444455555544444 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (335 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 6079 (0.0687102); expected 1769.5 (0.02) Passed bias filter: 2645 (0.0298961); expected 1769.5 (0.02) Passed Vit filter: 275 (0.00310829); expected 88.5 (0.001) Passed Fwd filter: 53 (0.000599053); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 33 [number of targets reported over threshold] # CPU time: 1.57u 0.05s 00:00:01.62 Elapsed: 00:00:00.44 # Mc/sec: 26701.42 // [ok]