# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/DNA_methylase.hmm.txt
# target sequence database: proteomes/Mus_musculus.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: DNA_methylase [M=335]
Accession: PF00145.17
Description: C-5 cytosine-specific DNA methylase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
1.8e-47 162.7 2.5 6.9e-47 160.7 0.0 2.9 2 sp|P13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1
2.3e-42 145.9 0.0 2.9e-42 145.5 0.0 1.1 1 sp|O55055|TRDMT_MOUSE tRNA (cytosine(38)-C(5))-methyltransf
3.9e-17 62.9 0.8 2.4e-12 47.2 0.0 2.7 3 sp|O88509|DNM3B_MOUSE DNA (cytosine-5)-methyltransferase 3B
4.6e-16 59.4 0.0 1.1e-11 45.0 0.0 2.4 2 sp|O88508|DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A
8.4e-16 58.5 0.0 1.7e-10 41.1 0.0 2.4 3 sp|P0DOY1|DNM3C_MOUSE DNA (cytosine-5)-methyltransferase 3C
0.00081 19.1 0.0 0.0014 18.4 0.0 1.3 1 sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=M
------ inclusion threshold ------
0.29 10.7 0.0 0.49 10.0 0.0 1.3 1 sp|Q8BG71|TYW2_MOUSE tRNA wybutosine-synthesizing protein
0.74 9.4 7.2 1.3 8.6 7.2 1.4 1 sp|Q6QD59|SEC20_MOUSE Vesicle transport protein SEC20 OS=Mu
3.3 7.3 8.7 71 2.9 0.0 2.7 2 tr|E9PV98|E9PV98_MOUSE Tripartite motif-containing 5 OS=Mus
Domain annotation for each sequence (and alignments):
>> sp|P13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 OS=Mus musculus OX=10090 GN=Dnmt1 PE=1 SV=5
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -10.4 8.1 9 2.2e+04 228 228 .. 262 262 .. 147 356 .. 0.47
2 ! 160.7 0.0 2.8e-50 6.9e-47 2 334 .. 1143 1595 .. 1142 1596 .. 0.71
Alignments for each domain:
== domain 1 score: -10.4 bits; conditional E-value: 9
- CS
DNA_methylase 228 g 228
+
sp|P13864|DNMT1_MOUSE 262 A 262
1 PP
== domain 2 score: 160.7 bits; conditional E-value: 2.8e-50
EEEEES-TT-HHHHHHHHTT.-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-............GS--...-SEEEE--- CS
DNA_methylase 2 kfidLfaGiGGfrlgleaag.fecvaaseidkkaaktYeanfk..kvsigDitkidkk............klpe..diDlLvgGfP 70
+++d f+G+GG++ g+++ag e+ +a+e+++ aa+ ++ n++ v ++D + + k lp+ d+++L+gG+P
sp|P13864|DNMT1_MOUSE 1143 RTLDVFSGCGGLSEGFHQAGiSETLWAIEMWDPAAQAFRLNNPgtTVFTEDCNVLLKLvmagevtnslgqRLPQkgDVEMLCGGPP 1228
789*****************99**********************844455555444445666666777779998667********* PP
GGGTECTSE..E--TTSGGGHHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB--E CS
DNA_methylase 71 CqpfSvaGk..qkgfedtrgtLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQnRe 154
Cq+fS ++ + +++L + + + + ++P +fllENV++ ++ +++ +lk l l +GY++++ +l+a +yGv+Q R+
sp|P13864|DNMT1_MOUSE 1229 CQGFSGMNRfnSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRR 1314
*****887654666677777****************************************************************** PP
EEEEEEEEGGG---...............-------SS---GGG..............TSGGGTTS-EEBTTTB--GGGSSSTT-E CS
DNA_methylase 155 Rvfivgirkdleln...............vlvkvkefrfpkkkd.........leasktlrdlleekseldeektalsdklvekee 216
R +i++ +++l ++v v +++f ++ ++++t+ dl+e ++ + s+ ++ e
sp|P13864|DNMT1_MOUSE 1315 RAIILAAAPGEKLPlfpeplhvfapracqLSVVVDDKKFVSNITrlssgpfrtITVRDTMSDLPEI-----QNGASNSEIPYNGEP 1395
*********998878776666665555553333333333333334455544443333333333332.....222222233333334 PP
E--.......S---HHHTS--..............................................................B-- CS
DNA_methylase 217 kikkttkaseegypkelsrnr..............................................................idk 240
++ +++ ++ y+ + r+ +
sp|P13864|DNMT1_MOUSE 1396 LSWFQRQLRGSHYQ-PILRDHickdmsplvaarmrhiplfpgsdwrdlpniqvrlgdgviahklqytfhdvkngysstgalrgV-- 1478
44444444444444.222222566667777777889999999999999999888888777666666655544444444444440.. PP
TTS...-B----S-STT-............................................-B-TTS---EEEETTEEE--T.TT CS
DNA_methylase 241 veelkglsatrrksgrge............................................klekelaeagklqknkerfkpvie 282
+ ++ +++ ++++k+++ v++
sp|P13864|DNMT1_MOUSE 1479 -----------------CscaegkacdpesrqfstlipwclphtgnrhnhwaglygrlewdgFFSTTVTNPEPMGKQGR----VLH 1543
.................03344445555555555555555555555555555555555444466666777777777777....9** PP
GGG--B-BHHHHHHHHT--TT-----SBHHHHHHHHTS--HHHHHHHHHHHH CS
DNA_methylase 283 kkriRrLtprEaarlqGfPddfefgskksaaykqiGnsVpvpvieaiakeik 334
++++R ++rE+ar qGfPd++ f ++ ++ +q+Gn+Vp+p+++ai+ eik
sp|P13864|DNMT1_MOUSE 1544 PEQHRVVSVRECARSQGFPDSYRFFGNILDRHRQVGNAVPPPLAKAIGLEIK 1595
***********************************************99986 PP
>> sp|O55055|TRDMT_MOUSE tRNA (cytosine(38)-C(5))-methyltransferase OS=Mus musculus OX=10090 GN=Trdmt1 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 145.5 0.0 1.2e-45 2.9e-42 2 331 .. 5 387 .. 4 391 .. 0.74
Alignments for each domain:
== domain 1 score: 145.5 bits; conditional E-value: 1.2e-45
EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--..-SEEEE---GGGTECTSEE--TT CS
DNA_methylase 2 kfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.diDlLvgGfPCqpfSvaGkqkgfe 84
++++L +GiGG++++l++ +vaa++ + a ++Y+ nf+ + i+ i+ +++ + ++ +++ ++PCqpf G q ++
sp|O55055|TRDMT_MOUSE 5 RVLELYSGIGGMHHALRESHipAHVVAAIDVNTVANEVYKHNFPhtHLLSKTIEGISLEDFDKlSFNMILMSPPCQPFTRIGLQGDMT 92
899****************9999*********************553444455555555899888*********************** PP
SGGGHHHHHHHHHHHHH-..-SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB--EEEEEEEEEGGG---.. CS
DNA_methylase 85 dtrgtLffeiiriikekk..PkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQnReRvfivgirkdleln.. 168
d+r t f +i i+ + Pk++llENVkg + t ++++ e +G++++ ll s G+p +R R f+++ +++++
sp|O55055|TRDMT_MOUSE 93 DPRTTSFLYILDILPRLQklPKYILLENVKGFEVS---STRGLLIQTIEACGFQYQEFLLSPSSLGIPNSRLRYFLIAKLQSEPFPfq 177
**************998888***********9888...456678999***********************************998788 PP
..........-------SS---GGG.......TSGGGTTS-EEBTTTB--GGGSSSTT-EE--.......S---H..HHTS--..... CS
DNA_methylase 169 ..........vlvkvkefrfpkkkd..leasktlrdlleekseldeektalsdklvekeekikkttkaseegypk..elsrnr..... 237
++v+v+ +++ ++ ++ t ++ e +++++++ +d ++ k e+++++ + +++ + ++ ++
sp|O55055|TRDMT_MOUSE 178 apgqilmefpKIVTVEPQKYAVVEEsqPRVQRTGPRICAE---SSSTQSSGKDTILFKLETVEERDRKHQQDSDLsvQMLKDFledgd 262
8888776666444444444433332223333333333333...566666666666666666665554444444422233333377888 PP
................................B--TTS...-B----S-STT--B-TTS---EEEETTEEE--T.TTGGG--B-BHHH CS
DNA_methylase 238 ................................idkveelkglsatrrksgrgeklekelaeagklqknkerfkpviekkriRrLtprE 293
+ ++ + +g+ + ++ ++ +++e+ ++ + l +++ ++ + R +tp+E
sp|O55055|TRDMT_MOUSE 263 tdeyllppklllryallldivkptsrrsmcftKGYGSYIEGTGSVLQAAED-AQIENIYKSLPDLPPEEKIA--KLSMLKLRYFTPKE 347
899999999997777777777776655555443333333333333333332.23333333333333333332..478899******** PP
HHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS
DNA_methylase 294 aarlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331
a lqGfP +f f++k++ ++y+++Gns++v v+ +++
sp|O55055|TRDMT_MOUSE 348 IANLQGFPPEFGFPEKTTvkQRYRLLGNSLNVHVVAKLLT 387
***********************************99876 PP
>> sp|O88509|DNM3B_MOUSE DNA (cytosine-5)-methyltransferase 3B OS=Mus musculus OX=10090 GN=Dnmt3b PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -4.1 0.2 4 9.8e+03 235 256 .. 371 392 .. 345 428 .. 0.47
2 ! 47.2 0.0 9.5e-16 2.4e-12 1 120 [. 581 714 .. 581 731 .. 0.88
3 ! 13.7 0.0 1.5e-05 0.038 252 331 .. 771 850 .. 734 854 .. 0.79
Alignments for each domain:
== domain 1 score: -4.1 bits; conditional E-value: 4
S--B--TTS...-B----S-ST CS
DNA_methylase 235 rnridkveelkglsatrrksgr 256
r+ ++ e+ + ++++rr++ +
sp|O88509|DNM3B_MOUSE 371 RSDSRNLEPRRRENKSRRRTTN 392
2223333333333333333333 PP
== domain 2 score: 47.2 bits; conditional E-value: 9.5e-16
-EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.EE- CS
DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.kqk 81
+++++Lf+Gi l l++ g +e ++ase + +++ +++ + +D++ki+kk+++e +Dl++gG PC++ S ++k
sp|O88509|DNM3B_MOUSE 581 IRVLSLFDGIATGYLVLKELGikVEKYIASEVCAESIAVGTVKHEgqIKYVNDVRKITKKNIEEwGpFDLVIGGSPCNDLSNVNpARK 668
5899*****************99999*********9999888888878999***********98747**************87626** PP
-TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS
DNA_methylase 82 gfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120
g + g Lffe+ +++ ++ P + ++ENV ++ +dk+
sp|O88509|DNM3B_MOUSE 669 GLYEGTGRLFFEFYHLLNYTRpkegdnrPFFWMFENVVAMKVNDKK 714
******************9995555555668899***999988876 PP
== domain 3 score: 13.7 bits; conditional E-value: 1.5e-05
-S-STT--B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS
DNA_methylase 252 rksgrgeklekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331
+++ +k+++ ++++++ ++ k++ pv+ + + L E+ r+ GfP ++ s+ a+ k++G s +vpvi++++
sp|O88509|DNM3B_MOUSE 771 TAKL--KKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 850
2222..267777888888888888888899***********************999888888*****************986 PP
>> sp|O88508|DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A OS=Mus musculus OX=10090 GN=Dnmt3a PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 45.0 0.0 4.4e-15 1.1e-11 1 120 [. 630 763 .. 630 772 .. 0.88
2 ! 12.0 0.0 4.7e-05 0.12 262 332 .. 828 900 .. 780 903 .. 0.76
Alignments for each domain:
== domain 1 score: 45.0 bits; conditional E-value: 4.4e-15
-EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.EE- CS
DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.kqk 81
+++++Lf+Gi l l+ g ++ ++ase ++ +++ +++ + gD++ +++k ++e +Dl++gG PC++ S+ ++k
sp|O88508|DNM3A_MOUSE 630 IRVLSLFDGIATGLLVLKDLGiqVDRYIASEVCEDSITVGMVRHQgkIMYVGDVRSVTQKHIQEwGpFDLVIGGSPCNDLSIVNpARK 717
5899*****************99999*********999999999988999**********9998647**************98736** PP
-TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS
DNA_methylase 82 gfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120
g + g Lffe+ r++ + + P + l+ENV + +dk+
sp|O88508|DNM3A_MOUSE 718 GLYEGTGRLFFEFYRLLHDARpkegddrPFFWLFENVVAMGVSDKR 763
*******************995555555568899999888776664 PP
== domain 2 score: 12.0 bits; conditional E-value: 4.7e-05
TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHHH CS
DNA_methylase 262 kelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiake 332
+ ++++++ + k + pv ++++ L E+ r+ GfP ++ s+ s a+ +++G s +vpvi++++
sp|O88508|DNM3A_MOUSE 828 TITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSrlARQRLLGRSWSVPVIRHLFAP 900
33333333333333334588899999999***************999999889999*************9875 PP
>> sp|P0DOY1|DNM3C_MOUSE DNA (cytosine-5)-methyltransferase 3C OS=Mus musculus OX=10090 GN=Dnmt3c PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -4.2 0.0 4.1 1e+04 69 86 .. 151 168 .. 149 169 .. 0.85
2 ! 41.1 0.0 6.8e-14 1.7e-10 1 118 [. 462 593 .. 462 612 .. 0.86
3 ! 14.9 0.0 6.4e-06 0.016 254 331 .. 654 731 .. 623 735 .. 0.79
Alignments for each domain:
== domain 1 score: -4.2 bits; conditional E-value: 4.1
--GGGTECTSEE--TTSG CS
DNA_methylase 69 fPCqpfSvaGkqkgfedt 86
P ++S+ +q+g+++t
sp|P0DOY1|DNM3C_MOUSE 151 TPSVDWSQDSHQEGMDTT 168
57789**********987 PP
== domain 2 score: 41.1 bits; conditional E-value: 6.8e-14
-EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTSE.E- CS
DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaGk.qk 81
+++++Lf+Gi l l++ g +e ++ase + +++ +++ + Di++i+k+ + e +Dl++gG PC++ S +k
sp|P0DOY1|DNM3C_MOUSE 462 IRVLSLFDGIATGYLVLKELGikVEKYIASEVCAESIAVGTVKHEgqIKYVDDIRNITKEHIDEwGpFDLVIGGSPCNDLSCVNPvRK 549
5899*****************99999*********99998888888788899********9997647**************88765** PP
-TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGC CS
DNA_methylase 82 gfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhd 118
g + g Lffe+ r+++ P + ++ENV + d
sp|P0DOY1|DNM3C_MOUSE 550 GLFEGTGRLFFEFYRLLNYSCpeeeddrPFFWMFENVVAMEVGD 593
*****************75543444455999999**98776555 PP
== domain 3 score: 14.9 bits; conditional E-value: 6.4e-06
-STT--B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS
DNA_methylase 254 sgrgeklekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331
+ +k+++ ++++++ ++ k++ pv+ + + L E+ r+ GfP+ ++ s+ a+ k++G s +vpvi++++
sp|P0DOY1|DNM3C_MOUSE 654 KL--KKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPEHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 731
22..2677778888888888888888999**********************999888888*****************986 PP
>> sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=Mus musculus OX=10090 GN=Mettl5 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.4 0.0 5.5e-07 0.0014 3 57 .. 55 111 .. 54 128 .. 0.78
Alignments for each domain:
== domain 1 score: 18.4 bits; conditional E-value: 5.5e-07
EEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-.-SEEEES-TTTS-..G CS
DNA_methylase 3 fidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfkkvsigDitkidkk..k 57
+ dL +G+G +++g ++ g ++ +id++a +++++n ++ ++ +++ i+ + +
sp|Q8K1A0|METL5_MOUSE 55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDvyS 111
689**************************************7777766666655443 PP
>> sp|Q8BG71|TYW2_MOUSE tRNA wybutosine-synthesizing protein 2 homolog OS=Mus musculus OX=10090 GN=Trmt12 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.0 0.0 0.0002 0.49 4 54 .. 229 288 .. 227 298 .. 0.75
Alignments for each domain:
== domain 1 score: 10.0 bits; conditional E-value: 0.0002
EEES-TT-HHHHHH.HHTT-EEEEEEE--TTTHHHHHHH-.........-SEEEES-TTT CS
DNA_methylase 4 idLfaGiGGfrlgl.eaagfecvaaseidkkaaktYeanfk........kvsigDitkid 54
+dL aGiG f+l + ag v a e++++a+ +++n + + ++gD +k++
sp|Q8BG71|TYW2_MOUSE 229 VDLYAGIGYFTLPFlVHAGAAFVHACEWNPHAVVALRNNLEingvadrcQIHFGDNRKLK 288
8***********8626788********************987664444444444444444 PP
>> sp|Q6QD59|SEC20_MOUSE Vesicle transport protein SEC20 OS=Mus musculus OX=10090 GN=Bnip1 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 8.6 7.2 0.00051 1.3 175 291 .. 48 201 .. 4 207 .. 0.55
Alignments for each domain:
== domain 1 score: 8.6 bits; conditional E-value: 0.00051
-SS---GGG.....TSGGGTTS-EE.........BTTTB--GGGSSSTT-EE--.......S---H....HHTS--............ CS
DNA_methylase 175 efrfpkkkdleasktlrdlleekse.........ldeektalsdklvekeekikkttkaseegypk....elsrnr............ 237
+++f+ + ++++++l+++++e l +e +++++++++++ +++k++ +++ ++++ e
sp|Q6QD59|SEC20_MOUSE 48 KEKFQ-----QLKQRIQELEQSAREqdkesekqlLLQEVENHKKQMLSNQTSWRKANLTCKLAIDNlekaE----Llqggdslrqrkt 126
12222.....3333333333333333211122345666666666666666666666666666666432221....1333333332233 PP
.B--TTS...-B----S-STT-.............................-B-TTS---EEEETTEEE--T...........TTGGG CS
DNA_methylase 238 .idkveelkglsatrrksgrge.............................klekelaeagklqknkerfkp..........viekkr 285
+ e +++ + + +l + +e+fk+ +i+k++
sp|Q6QD59|SEC20_MOUSE 127 tK-------------------EslaqtsssiteslmgisrmmsqqvqqseeAMQTLVSSSRTLLDANEEFKSmsgtiqlgrkLITKYN 195
30...................1333334444455555555555555555667777777777777777777779999999999999999 PP
--B-BH CS
DNA_methylase 286 iRrLtp 291
R+Lt
sp|Q6QD59|SEC20_MOUSE 196 RRELTD 201
999986 PP
>> tr|E9PV98|E9PV98_MOUSE Tripartite motif-containing 5 OS=Mus musculus OX=10090 GN=Trim5 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 0.9 8.8 0.12 2.9e+02 169 243 .. 192 265 .. 113 332 .. 0.56
2 ? 2.9 0.0 0.029 71 152 168 .. 384 400 .. 374 422 .. 0.81
Alignments for each domain:
== domain 1 score: 0.9 bits; conditional E-value: 0.12
-------SS---GGG.....TSGGGTTS-EEBTTTB--GGGSSSTT-EE--.......S---HHHTS--B--TTS CS
DNA_methylase 169 vlvkvkefrfpkkkdleasktlrdlleekseldeektalsdklvekeekikkttkaseegypkelsrnridkvee 243
++ ++++++++k + e+ ++l++l+e++se+ ++ l+d + + e + + ++ ++g+++ + r+ + ++++
tr|E9PV98|E9PV98_MOUSE 192 IIDSEEKNELQKLR-QEKEDILNNLAESESEHAQQSKLLEDFISDVEHQLQCSDIEILQGVENIIKRSLTFSMKK 265
22222333333333.244555555555555555555555555555555555555555555554444444444444 PP
== domain 2 score: 2.9 bits; conditional E-value: 0.029
--EEEEEEEEEGGG--- CS
DNA_methylase 152 nReRvfivgirkdleln 168
+R+R+f+ gi++d++++
tr|E9PV98|E9PV98_MOUSE 384 ERNRLFCRGIKNDSHYQ 400
7************9987 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (335 nodes)
Target sequences: 22289 (11757923 residues searched)
Passed MSV filter: 1702 (0.0763605); expected 445.8 (0.02)
Passed bias filter: 665 (0.0298353); expected 445.8 (0.02)
Passed Vit filter: 61 (0.00273678); expected 22.3 (0.001)
Passed Fwd filter: 12 (0.000538382); expected 0.2 (1e-05)
Initial search space (Z): 22289 [actual number of targets]
Domain search space (domZ): 9 [number of targets reported over threshold]
# CPU time: 0.42u 0.02s 00:00:00.44 Elapsed: 00:00:00.13
# Mc/sec: 30299.26
//
[ok]