# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/DNA_methylase.hmm.txt # target sequence database: proteomes/Mus_musculus.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: DNA_methylase [M=335] Accession: PF00145.17 Description: C-5 cytosine-specific DNA methylase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 1.8e-47 162.7 2.5 6.9e-47 160.7 0.0 2.9 2 sp|P13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 2.3e-42 145.9 0.0 2.9e-42 145.5 0.0 1.1 1 sp|O55055|TRDMT_MOUSE tRNA (cytosine(38)-C(5))-methyltransf 3.9e-17 62.9 0.8 2.4e-12 47.2 0.0 2.7 3 sp|O88509|DNM3B_MOUSE DNA (cytosine-5)-methyltransferase 3B 4.6e-16 59.4 0.0 1.1e-11 45.0 0.0 2.4 2 sp|O88508|DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A 8.4e-16 58.5 0.0 1.7e-10 41.1 0.0 2.4 3 sp|P0DOY1|DNM3C_MOUSE DNA (cytosine-5)-methyltransferase 3C 0.00081 19.1 0.0 0.0014 18.4 0.0 1.3 1 sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=M ------ inclusion threshold ------ 0.29 10.7 0.0 0.49 10.0 0.0 1.3 1 sp|Q8BG71|TYW2_MOUSE tRNA wybutosine-synthesizing protein 0.74 9.4 7.2 1.3 8.6 7.2 1.4 1 sp|Q6QD59|SEC20_MOUSE Vesicle transport protein SEC20 OS=Mu 3.3 7.3 8.7 71 2.9 0.0 2.7 2 tr|E9PV98|E9PV98_MOUSE Tripartite motif-containing 5 OS=Mus Domain annotation for each sequence (and alignments): >> sp|P13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 OS=Mus musculus OX=10090 GN=Dnmt1 PE=1 SV=5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -10.4 8.1 9 2.2e+04 228 228 .. 262 262 .. 147 356 .. 0.47 2 ! 160.7 0.0 2.8e-50 6.9e-47 2 334 .. 1143 1595 .. 1142 1596 .. 0.71 Alignments for each domain: == domain 1 score: -10.4 bits; conditional E-value: 9 - CS DNA_methylase 228 g 228 + sp|P13864|DNMT1_MOUSE 262 A 262 1 PP == domain 2 score: 160.7 bits; conditional E-value: 2.8e-50 EEEEES-TT-HHHHHHHHTT.-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-............GS--...-SEEEE--- CS DNA_methylase 2 kfidLfaGiGGfrlgleaag.fecvaaseidkkaaktYeanfk..kvsigDitkidkk............klpe..diDlLvgGfP 70 +++d f+G+GG++ g+++ag e+ +a+e+++ aa+ ++ n++ v ++D + + k lp+ d+++L+gG+P sp|P13864|DNMT1_MOUSE 1143 RTLDVFSGCGGLSEGFHQAGiSETLWAIEMWDPAAQAFRLNNPgtTVFTEDCNVLLKLvmagevtnslgqRLPQkgDVEMLCGGPP 1228 789*****************99**********************844455555444445666666777779998667********* PP GGGTECTSE..E--TTSGGGHHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB--E CS DNA_methylase 71 CqpfSvaGk..qkgfedtrgtLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQnRe 154 Cq+fS ++ + +++L + + + + ++P +fllENV++ ++ +++ +lk l l +GY++++ +l+a +yGv+Q R+ sp|P13864|DNMT1_MOUSE 1229 CQGFSGMNRfnSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRR 1314 *****887654666677777****************************************************************** PP EEEEEEEEGGG---...............-------SS---GGG..............TSGGGTTS-EEBTTTB--GGGSSSTT-E CS DNA_methylase 155 Rvfivgirkdleln...............vlvkvkefrfpkkkd.........leasktlrdlleekseldeektalsdklvekee 216 R +i++ +++l ++v v +++f ++ ++++t+ dl+e ++ + s+ ++ e sp|P13864|DNMT1_MOUSE 1315 RAIILAAAPGEKLPlfpeplhvfapracqLSVVVDDKKFVSNITrlssgpfrtITVRDTMSDLPEI-----QNGASNSEIPYNGEP 1395 *********998878776666665555553333333333333334455544443333333333332.....222222233333334 PP E--.......S---HHHTS--..............................................................B-- CS DNA_methylase 217 kikkttkaseegypkelsrnr..............................................................idk 240 ++ +++ ++ y+ + r+ + sp|P13864|DNMT1_MOUSE 1396 LSWFQRQLRGSHYQ-PILRDHickdmsplvaarmrhiplfpgsdwrdlpniqvrlgdgviahklqytfhdvkngysstgalrgV-- 1478 44444444444444.222222566667777777889999999999999999888888777666666655544444444444440.. PP TTS...-B----S-STT-............................................-B-TTS---EEEETTEEE--T.TT CS DNA_methylase 241 veelkglsatrrksgrge............................................klekelaeagklqknkerfkpvie 282 + ++ +++ ++++k+++ v++ sp|P13864|DNMT1_MOUSE 1479 -----------------CscaegkacdpesrqfstlipwclphtgnrhnhwaglygrlewdgFFSTTVTNPEPMGKQGR----VLH 1543 .................03344445555555555555555555555555555555555444466666777777777777....9** PP GGG--B-BHHHHHHHHT--TT-----SBHHHHHHHHTS--HHHHHHHHHHHH CS DNA_methylase 283 kkriRrLtprEaarlqGfPddfefgskksaaykqiGnsVpvpvieaiakeik 334 ++++R ++rE+ar qGfPd++ f ++ ++ +q+Gn+Vp+p+++ai+ eik sp|P13864|DNMT1_MOUSE 1544 PEQHRVVSVRECARSQGFPDSYRFFGNILDRHRQVGNAVPPPLAKAIGLEIK 1595 ***********************************************99986 PP >> sp|O55055|TRDMT_MOUSE tRNA (cytosine(38)-C(5))-methyltransferase OS=Mus musculus OX=10090 GN=Trdmt1 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 145.5 0.0 1.2e-45 2.9e-42 2 331 .. 5 387 .. 4 391 .. 0.74 Alignments for each domain: == domain 1 score: 145.5 bits; conditional E-value: 1.2e-45 EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--..-SEEEE---GGGTECTSEE--TT CS DNA_methylase 2 kfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.diDlLvgGfPCqpfSvaGkqkgfe 84 ++++L +GiGG++++l++ +vaa++ + a ++Y+ nf+ + i+ i+ +++ + ++ +++ ++PCqpf G q ++ sp|O55055|TRDMT_MOUSE 5 RVLELYSGIGGMHHALRESHipAHVVAAIDVNTVANEVYKHNFPhtHLLSKTIEGISLEDFDKlSFNMILMSPPCQPFTRIGLQGDMT 92 899****************9999*********************553444455555555899888*********************** PP SGGGHHHHHHHHHHHHH-..-SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB--EEEEEEEEEGGG---.. CS DNA_methylase 85 dtrgtLffeiiriikekk..PkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQnReRvfivgirkdleln.. 168 d+r t f +i i+ + Pk++llENVkg + t ++++ e +G++++ ll s G+p +R R f+++ +++++ sp|O55055|TRDMT_MOUSE 93 DPRTTSFLYILDILPRLQklPKYILLENVKGFEVS---STRGLLIQTIEACGFQYQEFLLSPSSLGIPNSRLRYFLIAKLQSEPFPfq 177 **************998888***********9888...456678999***********************************998788 PP ..........-------SS---GGG.......TSGGGTTS-EEBTTTB--GGGSSSTT-EE--.......S---H..HHTS--..... CS DNA_methylase 169 ..........vlvkvkefrfpkkkd..leasktlrdlleekseldeektalsdklvekeekikkttkaseegypk..elsrnr..... 237 ++v+v+ +++ ++ ++ t ++ e +++++++ +d ++ k e+++++ + +++ + ++ ++ sp|O55055|TRDMT_MOUSE 178 apgqilmefpKIVTVEPQKYAVVEEsqPRVQRTGPRICAE---SSSTQSSGKDTILFKLETVEERDRKHQQDSDLsvQMLKDFledgd 262 8888776666444444444433332223333333333333...566666666666666666665554444444422233333377888 PP ................................B--TTS...-B----S-STT--B-TTS---EEEETTEEE--T.TTGGG--B-BHHH CS DNA_methylase 238 ................................idkveelkglsatrrksgrgeklekelaeagklqknkerfkpviekkriRrLtprE 293 + ++ + +g+ + ++ ++ +++e+ ++ + l +++ ++ + R +tp+E sp|O55055|TRDMT_MOUSE 263 tdeyllppklllryallldivkptsrrsmcftKGYGSYIEGTGSVLQAAED-AQIENIYKSLPDLPPEEKIA--KLSMLKLRYFTPKE 347 899999999997777777777776655555443333333333333333332.23333333333333333332..478899******** PP HHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS DNA_methylase 294 aarlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331 a lqGfP +f f++k++ ++y+++Gns++v v+ +++ sp|O55055|TRDMT_MOUSE 348 IANLQGFPPEFGFPEKTTvkQRYRLLGNSLNVHVVAKLLT 387 ***********************************99876 PP >> sp|O88509|DNM3B_MOUSE DNA (cytosine-5)-methyltransferase 3B OS=Mus musculus OX=10090 GN=Dnmt3b PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -4.1 0.2 4 9.8e+03 235 256 .. 371 392 .. 345 428 .. 0.47 2 ! 47.2 0.0 9.5e-16 2.4e-12 1 120 [. 581 714 .. 581 731 .. 0.88 3 ! 13.7 0.0 1.5e-05 0.038 252 331 .. 771 850 .. 734 854 .. 0.79 Alignments for each domain: == domain 1 score: -4.1 bits; conditional E-value: 4 S--B--TTS...-B----S-ST CS DNA_methylase 235 rnridkveelkglsatrrksgr 256 r+ ++ e+ + ++++rr++ + sp|O88509|DNM3B_MOUSE 371 RSDSRNLEPRRRENKSRRRTTN 392 2223333333333333333333 PP == domain 2 score: 47.2 bits; conditional E-value: 9.5e-16 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.EE- CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.kqk 81 +++++Lf+Gi l l++ g +e ++ase + +++ +++ + +D++ki+kk+++e +Dl++gG PC++ S ++k sp|O88509|DNM3B_MOUSE 581 IRVLSLFDGIATGYLVLKELGikVEKYIASEVCAESIAVGTVKHEgqIKYVNDVRKITKKNIEEwGpFDLVIGGSPCNDLSNVNpARK 668 5899*****************99999*********9999888888878999***********98747**************87626** PP -TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 82 gfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 g + g Lffe+ +++ ++ P + ++ENV ++ +dk+ sp|O88509|DNM3B_MOUSE 669 GLYEGTGRLFFEFYHLLNYTRpkegdnrPFFWMFENVVAMKVNDKK 714 ******************9995555555668899***999988876 PP == domain 3 score: 13.7 bits; conditional E-value: 1.5e-05 -S-STT--B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS DNA_methylase 252 rksgrgeklekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331 +++ +k+++ ++++++ ++ k++ pv+ + + L E+ r+ GfP ++ s+ a+ k++G s +vpvi++++ sp|O88509|DNM3B_MOUSE 771 TAKL--KKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 850 2222..267777888888888888888899***********************999888888*****************986 PP >> sp|O88508|DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A OS=Mus musculus OX=10090 GN=Dnmt3a PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 45.0 0.0 4.4e-15 1.1e-11 1 120 [. 630 763 .. 630 772 .. 0.88 2 ! 12.0 0.0 4.7e-05 0.12 262 332 .. 828 900 .. 780 903 .. 0.76 Alignments for each domain: == domain 1 score: 45.0 bits; conditional E-value: 4.4e-15 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.EE- CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.kqk 81 +++++Lf+Gi l l+ g ++ ++ase ++ +++ +++ + gD++ +++k ++e +Dl++gG PC++ S+ ++k sp|O88508|DNM3A_MOUSE 630 IRVLSLFDGIATGLLVLKDLGiqVDRYIASEVCEDSITVGMVRHQgkIMYVGDVRSVTQKHIQEwGpFDLVIGGSPCNDLSIVNpARK 717 5899*****************99999*********999999999988999**********9998647**************98736** PP -TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS DNA_methylase 82 gfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120 g + g Lffe+ r++ + + P + l+ENV + +dk+ sp|O88508|DNM3A_MOUSE 718 GLYEGTGRLFFEFYRLLHDARpkegddrPFFWLFENVVAMGVSDKR 763 *******************995555555568899999888776664 PP == domain 2 score: 12.0 bits; conditional E-value: 4.7e-05 TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHHH CS DNA_methylase 262 kelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiake 332 + ++++++ + k + pv ++++ L E+ r+ GfP ++ s+ s a+ +++G s +vpvi++++ sp|O88508|DNM3A_MOUSE 828 TITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSrlARQRLLGRSWSVPVIRHLFAP 900 33333333333333334588899999999***************999999889999*************9875 PP >> sp|P0DOY1|DNM3C_MOUSE DNA (cytosine-5)-methyltransferase 3C OS=Mus musculus OX=10090 GN=Dnmt3c PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -4.2 0.0 4.1 1e+04 69 86 .. 151 168 .. 149 169 .. 0.85 2 ! 41.1 0.0 6.8e-14 1.7e-10 1 118 [. 462 593 .. 462 612 .. 0.86 3 ! 14.9 0.0 6.4e-06 0.016 254 331 .. 654 731 .. 623 735 .. 0.79 Alignments for each domain: == domain 1 score: -4.2 bits; conditional E-value: 4.1 --GGGTECTSEE--TTSG CS DNA_methylase 69 fPCqpfSvaGkqkgfedt 86 P ++S+ +q+g+++t sp|P0DOY1|DNM3C_MOUSE 151 TPSVDWSQDSHQEGMDTT 168 57789**********987 PP == domain 2 score: 41.1 bits; conditional E-value: 6.8e-14 -EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTSE.E- CS DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaGk.qk 81 +++++Lf+Gi l l++ g +e ++ase + +++ +++ + Di++i+k+ + e +Dl++gG PC++ S +k sp|P0DOY1|DNM3C_MOUSE 462 IRVLSLFDGIATGYLVLKELGikVEKYIASEVCAESIAVGTVKHEgqIKYVDDIRNITKEHIDEwGpFDLVIGGSPCNDLSCVNPvRK 549 5899*****************99999*********99998888888788899********9997647**************88765** PP -TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGC CS DNA_methylase 82 gfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhd 118 g + g Lffe+ r+++ P + ++ENV + d sp|P0DOY1|DNM3C_MOUSE 550 GLFEGTGRLFFEFYRLLNYSCpeeeddrPFFWMFENVVAMEVGD 593 *****************75543444455999999**98776555 PP == domain 3 score: 14.9 bits; conditional E-value: 6.4e-06 -STT--B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHH CS DNA_methylase 254 sgrgeklekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiak 331 + +k+++ ++++++ ++ k++ pv+ + + L E+ r+ GfP+ ++ s+ a+ k++G s +vpvi++++ sp|P0DOY1|DNM3C_MOUSE 654 KL--KKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPEHYTDVSNMGrgARQKLLGRSWSVPVIRHLFA 731 22..2677778888888888888888999**********************999888888*****************986 PP >> sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=Mus musculus OX=10090 GN=Mettl5 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.4 0.0 5.5e-07 0.0014 3 57 .. 55 111 .. 54 128 .. 0.78 Alignments for each domain: == domain 1 score: 18.4 bits; conditional E-value: 5.5e-07 EEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-.-SEEEES-TTTS-..G CS DNA_methylase 3 fidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfkkvsigDitkidkk..k 57 + dL +G+G +++g ++ g ++ +id++a +++++n ++ ++ +++ i+ + + sp|Q8K1A0|METL5_MOUSE 55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDvyS 111 689**************************************7777766666655443 PP >> sp|Q8BG71|TYW2_MOUSE tRNA wybutosine-synthesizing protein 2 homolog OS=Mus musculus OX=10090 GN=Trmt12 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.0 0.0 0.0002 0.49 4 54 .. 229 288 .. 227 298 .. 0.75 Alignments for each domain: == domain 1 score: 10.0 bits; conditional E-value: 0.0002 EEES-TT-HHHHHH.HHTT-EEEEEEE--TTTHHHHHHH-.........-SEEEES-TTT CS DNA_methylase 4 idLfaGiGGfrlgl.eaagfecvaaseidkkaaktYeanfk........kvsigDitkid 54 +dL aGiG f+l + ag v a e++++a+ +++n + + ++gD +k++ sp|Q8BG71|TYW2_MOUSE 229 VDLYAGIGYFTLPFlVHAGAAFVHACEWNPHAVVALRNNLEingvadrcQIHFGDNRKLK 288 8***********8626788********************987664444444444444444 PP >> sp|Q6QD59|SEC20_MOUSE Vesicle transport protein SEC20 OS=Mus musculus OX=10090 GN=Bnip1 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 8.6 7.2 0.00051 1.3 175 291 .. 48 201 .. 4 207 .. 0.55 Alignments for each domain: == domain 1 score: 8.6 bits; conditional E-value: 0.00051 -SS---GGG.....TSGGGTTS-EE.........BTTTB--GGGSSSTT-EE--.......S---H....HHTS--............ CS DNA_methylase 175 efrfpkkkdleasktlrdlleekse.........ldeektalsdklvekeekikkttkaseegypk....elsrnr............ 237 +++f+ + ++++++l+++++e l +e +++++++++++ +++k++ +++ ++++ e sp|Q6QD59|SEC20_MOUSE 48 KEKFQ-----QLKQRIQELEQSAREqdkesekqlLLQEVENHKKQMLSNQTSWRKANLTCKLAIDNlekaE----Llqggdslrqrkt 126 12222.....3333333333333333211122345666666666666666666666666666666432221....1333333332233 PP .B--TTS...-B----S-STT-.............................-B-TTS---EEEETTEEE--T...........TTGGG CS DNA_methylase 238 .idkveelkglsatrrksgrge.............................klekelaeagklqknkerfkp..........viekkr 285 + e +++ + + +l + +e+fk+ +i+k++ sp|Q6QD59|SEC20_MOUSE 127 tK-------------------EslaqtsssiteslmgisrmmsqqvqqseeAMQTLVSSSRTLLDANEEFKSmsgtiqlgrkLITKYN 195 30...................1333334444455555555555555555667777777777777777777779999999999999999 PP --B-BH CS DNA_methylase 286 iRrLtp 291 R+Lt sp|Q6QD59|SEC20_MOUSE 196 RRELTD 201 999986 PP >> tr|E9PV98|E9PV98_MOUSE Tripartite motif-containing 5 OS=Mus musculus OX=10090 GN=Trim5 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 0.9 8.8 0.12 2.9e+02 169 243 .. 192 265 .. 113 332 .. 0.56 2 ? 2.9 0.0 0.029 71 152 168 .. 384 400 .. 374 422 .. 0.81 Alignments for each domain: == domain 1 score: 0.9 bits; conditional E-value: 0.12 -------SS---GGG.....TSGGGTTS-EEBTTTB--GGGSSSTT-EE--.......S---HHHTS--B--TTS CS DNA_methylase 169 vlvkvkefrfpkkkdleasktlrdlleekseldeektalsdklvekeekikkttkaseegypkelsrnridkvee 243 ++ ++++++++k + e+ ++l++l+e++se+ ++ l+d + + e + + ++ ++g+++ + r+ + ++++ tr|E9PV98|E9PV98_MOUSE 192 IIDSEEKNELQKLR-QEKEDILNNLAESESEHAQQSKLLEDFISDVEHQLQCSDIEILQGVENIIKRSLTFSMKK 265 22222333333333.244555555555555555555555555555555555555555555554444444444444 PP == domain 2 score: 2.9 bits; conditional E-value: 0.029 --EEEEEEEEEGGG--- CS DNA_methylase 152 nReRvfivgirkdleln 168 +R+R+f+ gi++d++++ tr|E9PV98|E9PV98_MOUSE 384 ERNRLFCRGIKNDSHYQ 400 7************9987 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (335 nodes) Target sequences: 22289 (11757923 residues searched) Passed MSV filter: 1702 (0.0763605); expected 445.8 (0.02) Passed bias filter: 665 (0.0298353); expected 445.8 (0.02) Passed Vit filter: 61 (0.00273678); expected 22.3 (0.001) Passed Fwd filter: 12 (0.000538382); expected 0.2 (1e-05) Initial search space (Z): 22289 [actual number of targets] Domain search space (domZ): 9 [number of targets reported over threshold] # CPU time: 0.42u 0.02s 00:00:00.44 Elapsed: 00:00:00.13 # Mc/sec: 30299.26 // [ok]