# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/DNA_methylase.hmm.txt
# target sequence database: proteomes/Natronomonas_moolapensis.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: DNA_methylase [M=335]
Accession: PF00145.17
Description: C-5 cytosine-specific DNA methylase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
8.2e-48 160.8 0.0 9.6e-48 160.5 0.0 1.0 1 tr|M1XQI7|M1XQI7_NATM8 Site-specific DNA-methyltransferase (
9e-42 140.9 0.0 1e-41 140.7 0.0 1.0 1 tr|M1Y1K5|M1Y1K5_NATM8 Site-specific DNA-methyltransferase (
0.0037 14.0 0.0 0.0047 13.6 0.0 1.1 1 tr|M1XN99|M1XN99_NATM8 tRNA(Phe) (4-demethylwyosine(37)-C(7)
Domain annotation for each sequence (and alignments):
>> tr|M1XQI7|M1XQI7_NATM8 Site-specific DNA-methyltransferase (Cytosine-specific) OS=Natronomonas moolapensis (strain D
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 160.5 0.0 1.1e-50 9.6e-48 2 333 .. 4 352 .. 3 354 .. 0.78
Alignments for each domain:
== domain 1 score: 160.5 bits; conditional E-value: 1.1e-50
EEEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-..-SEEEES-TTTS-......GS--...-SEEEE---GGGTECTSE CS
DNA_methylase 2 kfidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfk.kvsigDitkidkk......klpe..diDlLvgGfPCqpfSvaGk 79
+ +dLf+G GG+++gle+ag+++ + +++d++++ Ye+n+ + + D++ ++++ +p d D+L ++ PCqp+S G+
tr|M1XQI7|M1XQI7_NATM8 4 TAVDLFCGSGGLSHGLEQAGISVNVGVDKDPHCKHAYEQNIDaEYRQTDVRPLSQDpervarMFPWdsDLDVLGACAPCQPYSTMGQ 90
679************************************************99999999**98887545*****************9 PP
E--TTSGGG...HHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEE...EEEEEGGGTT-SB--EEEEEEE CS
DNA_methylase 80 qkgfedtrg...tLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevs...ykllnasdyGvpQnReRvfivg 160
+k ++ L+ +i +i + +P++++ ENV+++ k d + ++++++l++lGY+v+ k + + +yG+pQnR+R+++++
tr|M1XQI7|M1XQI7_NATM8 91 SKNKTHQDHqkwGLLKDIKKISEYVEPDIIITENVPQVRKDD---VYDEFVQTLKDLGYHVNddeNKKVYCPEYGIPQNRKRWVMMA 174
5554444434479************************99985...69999***********999989999***************** PP
EEGGG----------SS---GGG.....TSGGGTTS-EEBTTTB--GGGS.SSTT-EE--.......S---H.......HHTS--B- CS
DNA_methylase 161 irkdlelnvlvkvkefrfpkkkdleasktlrdlleekseldeektalsdk.lvekeekikkttkaseegypk.......elsrnrid 239
+++ ++++ ++ e++++ + +++++ l++ + + ++ l ++ +++++ + ++ +++++++ l ++++
tr|M1XQI7|M1XQI7_NATM8 175 SKEGP-ISLPDPLYENESEYPT---VREAIGHLPPLQAGEVHPEYDLHQArSLSEKNLERIRNMKPGGDWRLweedgltHLLADCHK 257
*9985.4556666666666664...56666666665544444444443330334444444456666666664444666655555577 PP
-TTS...-B----S-STT--B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH.....HHHHHHHTS- CS
DNA_methylase 240 kveelkglsatrrksgrgeklekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks.....aaykqiGnsV 321
k+ ++ +++r + k+ + ++++ ++ ++ f ++ + R+L+ E a lq+fP+d++f + + + ++iGn+V
tr|M1XQI7|M1XQI7_NATM8 258 KSSGRSYKAPYSRMEPD--KVAPTITTQFYNYGSGR-FG-HYDTDQDRALSLLEGALLQTFPEDYDFYDEWEevgvkNLGRLIGNAV 340
77776666666666664..44444444444433333.44.4899************************999989999999******* PP
-HHHHHHHHHHH CS
DNA_methylase 322 pvpvieaiakei 333
p+ + ++i++ i
tr|M1XQI7|M1XQI7_NATM8 341 PPLLGKHIGRGI 352
********9876 PP
>> tr|M1Y1K5|M1Y1K5_NATM8 Site-specific DNA-methyltransferase (Cytosine-specific) OS=Natronomonas moolapensis (strain D
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 140.7 0.0 1.1e-44 1e-41 2 333 .. 4 347 .. 3 349 .. 0.79
Alignments for each domain:
== domain 1 score: 140.7 bits; conditional E-value: 1.1e-44
EEEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-..-SEEEES-TTTS-.........GS--.-SEEEE---GGGTECTS CS
DNA_methylase 2 kfidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfk.kvsigDitkidkk.........klpediDlLvgGfPCqpfSvaG 78
+ idLf+G+GG++ gle+ag+ + a ++id++ Ye+n+ + ++Di +++ + + ++d lL g+ PCqpfS
tr|M1Y1K5|M1Y1K5_NATM8 4 SAIDLFCGAGGLTNGLERAGICVEAGIDIDPDSEFPYEQNNDaEFLLKDIAELAREepemvteyfDSEADATLLAGCAPCQPFSPLT 90
679***************************************************999*999974433335789***********988 PP
EE--TTSGGG.HHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEE...EEEEEGGGTT-SB--EEEEEEEE CS
DNA_methylase 79 kqkgfedtrg.tLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevs...ykllnasdyGvpQnReRvfivgi 161
+ ++ + ++ ++ + +i++e +P+++++ENV ++ + d + +++++ l++lGY+++ + + + +y++pQ R+R+++++
tr|M1Y1K5|M1Y1K5_NATM8 91 HGSDSSEHSKyGMLRAFLEIVRESDPDFVVMENVFEVRHAD---VYDEFIDGLDQLGYNLNpksDRRVYCPEYDIPQTRRRWVVLAS 174
7655555544579*********************9998885...69999************44434689****************** PP
EGGG---.-------SS---GGG......TSGGGTTS-EEBTTTB--GGGSSSTT-EE--.......S---HHHTS--B--TTS... CS
DNA_methylase 162 rkdleln.vlvkvkefrfpkkkd.leasktlrdlleekseldeektalsdklvekeekikkttkaseegypkelsrnridkveelkg 246
+k+++ + + + ++p+ kd + + l+ +++k d ta s + ++ ++ + + + s++++p e+ r k ++++
tr|M1Y1K5|M1Y1K5_NATM8 175 KKGRIDLgAPLNPEPADYPTVKDrIDHLDPLEAGETSK--EDPLHTARSLSETNIKRIRCSNPGGSWKDWP-EELRLDCHKKASGQT 258
**986557555555556666654233333333333333..3333444444444444444445688888888.777777777777788 PP
-B----S-STT--B-TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH.....HHHHHHHTS--HHHHHH CS
DNA_methylase 247 lsatrrksgrgeklekelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks.....aaykqiGnsVpvpviea 328
+ a + + +e+ + +++ ++l++ ++ + R+L+ rE a +q+fP+d+ f+ + + ++ ++iGn+Vp+ + e
tr|M1Y1K5|M1Y1K5_NATM8 259 YEAVYGRMVADEPAPTITTQFYNLGSGRFG---HYDTDQDRALSLREGAMIQTFPEDYRFADDLEeveiiKVGRLIGNAVPPRLGEV 342
888888888878888888888888777775...4899*************************999898999999**********999 PP
HHHHH CS
DNA_methylase 329 iakei 333
+++++
tr|M1Y1K5|M1Y1K5_NATM8 343 VGDRV 347
98876 PP
>> tr|M1XN99|M1XN99_NATM8 tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase OS=Natronomonas moolapen
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 13.6 0.0 5.2e-06 0.0047 2 42 .. 198 237 .. 197 261 .. 0.83
Alignments for each domain:
== domain 1 score: 13.6 bits; conditional E-value: 5.2e-06
EEEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH- CS
DNA_methylase 2 kfidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanf 42
+++d+faGiG f+l +++a+ v a+eid++a + n
tr|M1XN99|M1XN99_NATM8 198 RVFDMFAGIGYFSLPMARAE-ASVTAAEIDPTAHRRLVENA 237
689*****************.889999****9987666665 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (335 nodes)
Target sequences: 2723 (809592 residues searched)
Passed MSV filter: 68 (0.0249725); expected 54.5 (0.02)
Passed bias filter: 57 (0.0209328); expected 54.5 (0.02)
Passed Vit filter: 8 (0.00293794); expected 2.7 (0.001)
Passed Fwd filter: 3 (0.00110173); expected 0.0 (1e-05)
Initial search space (Z): 2723 [actual number of targets]
Domain search space (domZ): 3 [number of targets reported over threshold]
# CPU time: 0.02u 0.00s 00:00:00.02 Elapsed: 00:00:00.02
# Mc/sec: 13560.67
//
[ok]