# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/DNA_methylase.hmm.txt
# target sequence database: proteomes/Xenopus_tropicalis.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: DNA_methylase [M=335]
Accession: PF00145.17
Description: C-5 cytosine-specific DNA methylase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
8.4e-49 167.1 0.0 3.5e-48 165.1 0.0 2.1 2 tr|F6QE78|F6QE78_XENTR DNA (cytosine-5)-methyltransfera
4.3e-42 145.1 0.0 5.3e-42 144.8 0.0 1.1 1 tr|F6VLZ7|F6VLZ7_XENTR tRNA aspartic acid methyltransfe
5.5e-17 62.5 0.0 3.3e-12 46.8 0.0 2.4 2 tr|F7BU15|F7BU15_XENTR DNA (cytosine-5-)-methyltransfer
0.002 18.0 0.0 0.0038 17.0 0.0 1.4 1 tr|F7AIW5|F7AIW5_XENTR Methyltransferase-like 5 OS=Xeno
------ inclusion threshold ------
0.15 11.8 0.0 0.2 11.4 0.0 1.1 1 tr|A0A1B8XTI8|A0A1B8XTI8_XENTR Uncharacterized protein OS=Xenop
0.15 11.8 0.0 0.2 11.4 0.0 1.1 1 tr|F6SYY7|F6SYY7_XENTR Uncharacterized protein OS=Xenop
Domain annotation for each sequence (and alignments):
>> tr|F6QE78|F6QE78_XENTR DNA (cytosine-5)-methyltransferase OS=Xenopus tropicalis OX=8364 GN=dnmt1 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.2 0.5 1.4 5.5e+03 186 226 .. 273 313 .. 243 320 .. 0.59
2 ! 165.1 0.0 8.6e-52 3.5e-48 2 335 .] 1124 1577 .. 1123 1577 .. 0.73
Alignments for each domain:
== domain 1 score: -3.2 bits; conditional E-value: 1.4
...TSGGGTTS-EEBTTTB--GGGSSSTT-EE--....... CS
DNA_methylase 186 asktlrdlleekseldeektalsdklvekeekikkttkase 226
+ +++ ++++ e+++e+ +++ ++ e+e++++ t ++s+
tr|F6QE78|F6QE78_XENTR 273 KDTDVSADADQPEEKEKEEKRIKIEVNESENENRSTAEESK 313
22223222333334677777777777777777776666555 PP
== domain 2 score: 165.1 bits; conditional E-value: 8.6e-52
EEEEES-TT-HHHHHHHHTT.-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-............GS--...-SEEEE-- CS
DNA_methylase 2 kfidLfaGiGGfrlgleaag.fecvaaseidkkaaktYeanfk..kvsigDitkidkk............klpe..diDlLvgGf 69
+++d f+G+GG++ g+++ag e+ +a+e+++ aa+ ++ n++ v ++D + + k lp+ d+++L+gG+
tr|F6QE78|F6QE78_XENTR 1124 RTLDVFSGCGGLSEGFHQAGiSETNWAIEMWEPAAQAFRLNNPgtTVFTEDCNVLLKLvmsgektnslgqRLPQkgDVEMLCGGP 1208
789*****************99**********************755555655554445666677889999998667******** PP
-GGGTECTSE..E--TTSGGGHHHHHHHHHHHHH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB- CS
DNA_methylase 70 PCqpfSvaGk..qkgfedtrgtLffeiiriikekkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQn 152
PCq+fS ++ + +++L + + + + ++Pk+fllENV++ ++ +++ +lk l l +GY++++ +l+a +yGv+Q
tr|F6QE78|F6QE78_XENTR 1209 PCQGFSGMNRfnSRTYSKFKNSLVVSYLSYCDYYRPKYFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQT 1293
******887654666677777**************************************************************** PP
-EEEEEEEEEGGG---........................-------SS---GGG.....TSGGGTTS-EEBTTTB--GGGSSST CS
DNA_methylase 153 ReRvfivgirkdleln........................vlvkvkefrfpkkkdleasktlrdlleekseldeektalsdklve 213
R+R ++++ +++l + ++++ ++++ + ++++t+ dl+e + + + + ++
tr|F6QE78|F6QE78_XENTR 1294 RRRAIVLAAAPGEKLPmfpeplhvfapracslsvvvdekkYVSNITRTNSSLFRTITVRDTMSDLPEIR-----NGASALEISYN 1373
**********99987777877777777776655555444444444444444443344444444444432.....22222333334 PP
T-EE--.......S---HHHTS--.......................................B--TTS...-B----S-STT-. CS
DNA_methylase 214 keekikkttkaseegypkelsrnr.......................................idkveelkglsatrrksgrge. 258
e +++ +++ +++y++ + r+ + ++l+ +++++++g+
tr|F6QE78|F6QE78_XENTR 1374 GEPQSWFQRQIRGSQYQP-ILRDHvckdmsalvaarmrhiplapgsdwrdlpnmevrlsdgttT------RKLRYSHHDKKNGRs 1451
444444445555555553.333324666677777888899999999999988888775553332......222222222222224 PP
.....................................................-B-TTS---EEEETTEEE--T.TTGGG--B-B CS
DNA_methylase 259 .....................................................klekelaeagklqknkerfkpviekkriRrLt 290
++ +++ ++++k+++ v++++++R +
tr|F6QE78|F6QE78_XENTR 1452 stgalrgvcscsegkpcdpadrqfntlipwclphtgnrhnhwaglygrlewdgFFSTTVTNPEPMGKQGR----VLHPEQHRVVS 1532
4566677777777777777777777766666666666666666666666555555555556666666666....9********** PP
HHHHHHHHT--TT-----SBHHHHHHHHTS--HHHHHHHHHHHHH CS
DNA_methylase 291 prEaarlqGfPddfefgskksaaykqiGnsVpvpvieaiakeikk 335
+rE+ar qGfPd++ + ++ ++ +q+Gn+Vp+p+ +ai+ eikk
tr|F6QE78|F6QE78_XENTR 1533 VRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLSKAIGSEIKK 1577
******************************************986 PP
>> tr|F6VLZ7|F6VLZ7_XENTR tRNA aspartic acid methyltransferase 1 OS=Xenopus tropicalis OX=8364 GN=trdmt1 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 144.8 0.0 1.3e-45 5.3e-42 2 332 .. 6 390 .. 5 393 .. 0.71
Alignments for each domain:
== domain 1 score: 144.8 bits; conditional E-value: 1.3e-45
EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--..-SEEEE---GGGTECTSEE--T CS
DNA_methylase 2 kfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.diDlLvgGfPCqpfSvaGkqkgf 83
++++L +GiGG++ gl + g e+vaa++ + a ++Y+ nf+ + i+ ++ k+l + ++D+++ ++PCqpf G q ++
tr|F6VLZ7|F6VLZ7_XENTR 6 RVLELYSGIGGMHCGLTESGvaAEVVAAVDVNTIANEVYKYNFPytPLWPKSIEGLSLKELDAlSFDMILMSPPCQPFTRIGLQGDI 92
899*****************999*********************8878889999999999*9999********************** PP
TSGGGHHHHHHHHHHH..HH--SEEEEEEEGGGGGGCCSHHHHHHHHHHHHHTEEEEEEEEEGGGTT-SB--EEEEEEEEEGGG--- CS
DNA_methylase 84 edtrgtLffeiiriik..ekkPkvfllENVkgLlkhdkgktlkvilekleelGYevsykllnasdyGvpQnReRvfivgirkdleln 168
d+r + f ++ ++ +k+P+++llENVkg +++ + + ++ +le+ GY ++ ll G+p +R R f+++ +++++
tr|F6VLZ7|F6VLZ7_XENTR 93 SDPRTKSFLYVLDVLPrlKKQPAYILLENVKGFETSE---AREALIRTLEKGGYAYQEFLLSPTCLGIPNSRLRYFLIAKLQKEPFA 176
***************733678************9995...57788**************************************9988 PP
.......................-------SS---GGG.....TSGGGTTS-EE..BTTTB--GGGSSSTT-EE--.......S--- CS
DNA_methylase 169 .......................vlvkvkefrfpkkkdleasktlrdlleekse..ldeektalsdklvekeekikkttkaseegyp 230
+++ ++ r+++k+ s l+ ++ ++ ++ k e+ + + ++ ++ +
tr|F6VLZ7|F6VLZ7_XENTR 177 fpttskileefpsqcpgskriihCSESNPQARVEQKY---------------SScpLSGTDCDPEKTVLYKLETAVELQRKQTQDND 248
8666655555444444444444433444444444443...............33332222222222222222222222222222222 PP
H..HHTS--...................................B--TTS...-B----S-STT-......-B-TTS---EEEETTE CS
DNA_methylase 231 k..elsrnr...................................idkveelkglsatrrksgrge......klekelaeagklqknk 274
+ + +++ +kg+ ++++ +g+ + ++ ++++ l ++
tr|F6VLZ7|F6VLZ7_XENTR 249 SsvRM---LqdflegnveemsqyflppksllryalildivkptcRRSTCFTKGYGHYVEGTGS-VlqtatdVEIDTVYKSLDLLTEE 331
11111...1122233333344445666677666676666666664444444444444444443.13444445555666666666666 PP
EE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHHH CS
DNA_methylase 275 erfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiake 332
e+ ++ ++R +tprE l GfP +f f+++ + ++y+++Gns++v ++ ++
tr|F6VLZ7|F6VLZ7_XENTR 332 EKLA-KLSSLKMRYFTPREISNLHGFPATFGFPEEVTkkQRYRLLGNSLNVHIVSCLIST 390
6555.59999***********************998888*************99887766 PP
>> tr|F7BU15|F7BU15_XENTR DNA (cytosine-5-)-methyltransferase 3 alpha OS=Xenopus tropicalis OX=8364 GN=dnmt3a PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 46.8 0.0 8.3e-16 3.3e-12 1 120 [. 602 735 .. 602 744 .. 0.88
2 ! 13.2 0.0 1.4e-05 0.054 262 332 .. 800 872 .. 756 875 .. 0.77
Alignments for each domain:
== domain 1 score: 46.8 bits; conditional E-value: 8.3e-16
-EEEEES-TT-HHHHHHHHTT..-EEEEEEE--TTTHHHHHHH-...-SEEEES-TTTS-GS--...-SEEEE---GGGTECTS.EE CS
DNA_methylase 1 lkfidLfaGiGGfrlgleaag..fecvaaseidkkaaktYeanfk..kvsigDitkidkkklpe.d.iDlLvgGfPCqpfSvaG.kq 80
+++++Lf+Gi l l+ g +e ++ase ++ +++ +++ + gD+++i+ k ++e +Dl++gG PC++ S+ ++
tr|F7BU15|F7BU15_XENTR 602 IRVLSLFDGIATGLLVLKDLGihIERYIASEVCEDSITVGMVRHQgkIMYVGDVRNITRKHIQEwGpFDLVIGGSPCNDLSIVNpAR 688
5899*****************99999**********99999999988999**********9998647**************987369 PP
--TTSGGGHHHHHHHHHHHHH-.......-SEEEEEEEGGGGGGCCS CS
DNA_methylase 81 kgfedtrgtLffeiiriikekk.......PkvfllENVkgLlkhdkg 120
kg + g Lffe+ r++ e + P + l+ENV + +dk+
tr|F7BU15|F7BU15_XENTR 689 KGLFEGTGRLFFEFYRLLHEARpkegdnrPFFWLFENVVAMGVSDKR 735
********************995555555668899999888776664 PP
== domain 2 score: 13.2 bits; conditional E-value: 1.4e-05
TTS---EEEETTEEE--T.TTGGG--B-BHHHHHHHHT--TT-----SBH..HHHHHHHTS--HHHHHHHHHH CS
DNA_methylase 262 kelaeagklqknkerfkpviekkriRrLtprEaarlqGfPddfefgskks..aaykqiGnsVpvpvieaiake 332
+ ++++++ + k + pv+ ++++ L E+ r+ GfP ++ s+ s a+ +++G s +vpvi++++
tr|F7BU15|F7BU15_XENTR 800 TITTRSNSIKQGKDQHFPVYMNEKEDILWCTEMERVFGFPVHYTDVSNMSrlARQRLLGRSWSVPVIRHLFAP 872
333333333333333346999999999*****************999999889999*************9875 PP
>> tr|F7AIW5|F7AIW5_XENTR Methyltransferase-like 5 OS=Xenopus tropicalis OX=8364 GN=mettl5 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.0 0.0 9.5e-07 0.0038 3 65 .. 55 117 .. 54 129 .. 0.79
Alignments for each domain:
== domain 1 score: 17.0 bits; conditional E-value: 9.5e-07
EEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-.-SEEEES-TTTS-..GS--.-SEE CS
DNA_methylase 3 fidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfkkvsigDitkidkk..klpediDlL 65
+ dL +G+G +++g ++ g ++ + d++a +++++n ++ ++ +i+ i+ + +lp D L
tr|F7AIW5|F7AIW5_XENTR 55 VADLGCGCGVLSIGAAMLGAGLCLGLDVDEDALDIFKTNTEEFELTNIDMIQFDicSLP--PDCL 117
579**************************************555555555544333666..3544 PP
>> tr|A0A1B8XTI8|A0A1B8XTI8_XENTR Uncharacterized protein OS=Xenopus tropicalis OX=8364 GN=etfbkmt PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.4 0.0 4.9e-05 0.2 2 43 .. 103 144 .. 102 163 .. 0.87
Alignments for each domain:
== domain 1 score: 11.4 bits; conditional E-value: 4.9e-05
EEEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-. CS
DNA_methylase 2 kfidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfk 43
+++dL +G+G+ +++ + g + v+a++id+ a + ++ n +
tr|A0A1B8XTI8|A0A1B8XTI8_XENTR 103 SVLDLGCGCGAAAIAAGMGGASYVLANDIDPVAGEAFKLNCE 144
589************************************985 PP
>> tr|F6SYY7|F6SYY7_XENTR Uncharacterized protein OS=Xenopus tropicalis OX=8364 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.4 0.0 5.1e-05 0.2 2 43 .. 110 151 .. 109 170 .. 0.87
Alignments for each domain:
== domain 1 score: 11.4 bits; conditional E-value: 5.1e-05
EEEEES-TT-HHHHHHHHTT-EEEEEEE--TTTHHHHHHH-. CS
DNA_methylase 2 kfidLfaGiGGfrlgleaagfecvaaseidkkaaktYeanfk 43
+++dL +G+G+ +++ + g + v+a++id+ a + ++ n +
tr|F6SYY7|F6SYY7_XENTR 110 SVLDLGCGCGAAAIAAGMGGASYVLANDIDPVAGEAFKLNCE 151
589************************************985 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (335 nodes)
Target sequences: 24182 (11782085 residues searched)
Passed MSV filter: 1951 (0.0806798); expected 483.6 (0.02)
Passed bias filter: 819 (0.0338682); expected 483.6 (0.02)
Passed Vit filter: 132 (0.00545861); expected 24.2 (0.001)
Passed Fwd filter: 51 (0.00210901); expected 0.2 (1e-05)
Initial search space (Z): 24182 [actual number of targets]
Domain search space (domZ): 6 [number of targets reported over threshold]
# CPU time: 0.83u 0.03s 00:00:00.86 Elapsed: 00:00:00.33
# Mc/sec: 11960.60
//
[ok]