# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/DREV.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: DREV [M=265] Accession: PF05219.11 Description: DREV methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 3.4e-139 464.6 0.1 3.9e-139 464.4 0.1 1.0 1 sp|Q9H1A3|METL9_HUMAN Methyltransferase-like protein 9 OS= 1.8e-137 459.0 0.1 2.1e-137 458.8 0.1 1.0 1 sp|Q9H1A3-2|METL9_HUMAN Isoform 2 of Methyltransferase-like 2.6e-116 389.6 0.0 2.9e-116 389.5 0.0 1.0 1 tr|H3BN86|H3BN86_HUMAN Methyltransferase-like protein 9 (Fr 2.8e-72 245.3 0.0 3.1e-72 245.1 0.0 1.0 1 tr|H3BM54|H3BM54_HUMAN Methyltransferase-like protein 9 (Fr 5.8e-60 204.9 0.0 6.9e-60 204.6 0.0 1.0 1 tr|H3BQD2|H3BQD2_HUMAN Methyltransferase-like protein 9 (Fr 1.3e-52 180.7 0.5 4.4e-34 120.0 0.0 2.0 2 tr|H3BPE9|H3BPE9_HUMAN Methyltransferase-like protein 9 (Fr ------ inclusion threshold ------ 0.017 16.5 0.1 0.039 15.3 0.0 1.6 2 tr|B3KU92|B3KU92_HUMAN Putative protein arginine N-methyltr 0.021 16.2 0.1 0.048 15.0 0.0 1.5 1 sp|Q6P2P2|ANM10_HUMAN Putative protein arginine N-methyltr 0.21 12.9 0.0 1.9 9.8 0.0 2.3 3 sp|Q86X55-2|CARM1_HUMAN Isoform 2 of Histone-arginine methyl 0.26 12.6 0.0 0.32 12.3 0.0 1.1 1 tr|H7C2H9|H7C2H9_HUMAN Protein arginine N-methyltransferase 0.37 12.1 0.0 0.49 11.7 0.0 1.1 1 tr|B7U632|B7U632_HUMAN PRMT2 gamma variant OS=Homo sapiens 0.44 11.9 0.0 0.59 11.4 0.0 1.1 1 tr|A8MXR3|A8MXR3_HUMAN Protein arginine N-methyltransferase 0.46 11.8 0.0 0.67 11.3 0.0 1.2 1 sp|Q6UX53|MET7B_HUMAN Methyltransferase-like protein 7B OS 0.48 11.8 0.0 1.5 10.1 0.0 1.7 2 tr|K7EQA8|K7EQA8_HUMAN Histone-arginine methyltransferase C 0.53 11.6 0.0 0.72 11.2 0.0 1.1 1 sp|P55345-2|ANM2_HUMAN Isoform 2 of Protein arginine N-meth 0.53 11.6 0.0 0.74 11.1 0.0 1.1 1 tr|B7U630|B7U630_HUMAN PRMT2 alpha variant OS=Homo sapiens 0.57 11.5 0.0 0.79 11.0 0.0 1.1 1 tr|B7U631|B7U631_HUMAN PRMT2 beta variant OS=Homo sapiens G 0.58 11.5 0.0 2.9 9.2 0.0 2.1 2 sp|Q86X55-1|CARM1_HUMAN Isoform 1 of Histone-arginine methyl 0.63 11.3 0.0 3.1 9.1 0.0 2.0 2 sp|Q86X55|CARM1_HUMAN Histone-arginine methyltransferase C 0.65 11.3 0.0 0.92 10.8 0.0 1.2 1 sp|P55345-3|ANM2_HUMAN Isoform 3 of Protein arginine N-meth 0.78 11.1 0.0 1.2 10.5 0.0 1.2 1 sp|Q96LA8|ANM6_HUMAN Protein arginine N-methyltransferase 1 10.7 0.0 1.1 10.5 0.0 1.1 1 tr|D6RCL3|D6RCL3_HUMAN Probable dimethyladenosine transfera 1 10.7 0.0 1.2 10.4 0.0 1.0 1 tr|K7ESL0|K7ESL0_HUMAN Spermidine synthase (Fragment) OS=Ho Domain annotation for each sequence (and alignments): >> sp|Q9H1A3|METL9_HUMAN Methyltransferase-like protein 9 OS=Homo sapiens GN=METTL9 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 464.4 0.1 1e-142 3.9e-139 1 265 [] 56 317 .. 56 317 .. 1.00 Alignments for each domain: == domain 1 score: 464.4 bits; conditional E-value: 1e-142 DREV 1 Wyvlnre.lseslqalfvaslpdaetqsflenskklsanlfiqlyhalassilslfmsktdinGllgrGsmfvlseeqfrkllaieke 87 Wyv+nre l+eslqa+fv+s++d++tq+fl+ns+++s++lfiqlyh+++ss++slfms+t+inGllgrGsmfv+s++qf++ll+i+ sp|Q9H1A3|METL9_HUMAN 56 WYVCNREkLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKIN-- 141 *************************************************************************************9.. PP DREV 88 spasdqedkklldlGaGdGeitkrvaptfeevyatelsetmrdrlkkkkynvlsalelqetdvkldlilclnlldrcfdplklledir 175 +d+++++lldlGaGdGe+tk+++p+fee+yatelsetm+++l+kkky+vl+++e+q+t++++d+i+clnlldrc++pl+ll+dir sp|Q9H1A3|METL9_HUMAN 142 ---PDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIR 226 ...9************************************************************************************ PP DREV 176 salep.ngrvivalvlPvshyvetntgksekpsellevkGrsyeeevarlievlkkagfeveaftrlPylceGdlnnsfyylddaifv 262 s+lep +grvi+alvlP+++yve+++gk+ekpse+le+kG+++ee+v++l+ev++kagf++eaftrlPylceGd++n++y+ldda+fv sp|Q9H1A3|METL9_HUMAN 227 SVLEPtRGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVFV 314 *****9********************************************************************************** PP DREV 263 lkk 265 lk+ sp|Q9H1A3|METL9_HUMAN 315 LKP 317 *97 PP >> sp|Q9H1A3-2|METL9_HUMAN Isoform 2 of Methyltransferase-like protein 9 OS=Homo sapiens GN=METTL9 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 458.8 0.1 5.4e-141 2.1e-137 1 265 [] 56 316 .. 56 316 .. 0.99 Alignments for each domain: == domain 1 score: 458.8 bits; conditional E-value: 5.4e-141 DREV 1 Wyvlnre.lseslqalfvaslpdaetqsflenskklsanlfiqlyhalassilslfmsktdinGllgrGsmfvlseeqfrkllaie 85 Wyv+nre l+eslqa+fv+s++d++tq+fl+ns+++s++lfiqlyh+++ss++slfms+t+inGllgrGsmfv+s++qf++ll+i+ sp|Q9H1A3-2|METL9_HUMAN 56 WYVCNREkLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKIN 141 *************************************************************************************9 PP DREV 86 kespasdqedkklldlGaGdGeitkrvaptfeevyatelsetmrdrlkkkkynvlsalelqetdvkldlilclnlldrcfdplkll 171 +d+++++lldlGaGdGe+tk+++p+fee+yatelsetm+++l+kkky+vl+++e+q+t++++d+i+clnlldrc++pl+ll sp|Q9H1A3-2|METL9_HUMAN 142 -----PDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLL 222 .....9******************************************************************************** PP DREV 172 edirsalep.ngrvivalvlPvshyvetntgksekpsellevkGrsyeeevarlievlkkagfeveaftrlPylceGdlnnsfyyl 256 +dirs+lep +grvi+alvlP+++yve+ +gk+ekpse+le+kG+++ee+v++l+ev++kagf++eaftrlPylceGd++n++y+l sp|Q9H1A3-2|METL9_HUMAN 223 KDIRSVLEPtRGRVILALVLPFHPYVEN-GGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVL 307 *********9*****************6.56******************************************************* PP DREV 257 ddaifvlkk 265 dda+fvlk+ sp|Q9H1A3-2|METL9_HUMAN 308 DDAVFVLKP 316 *******97 PP >> tr|H3BN86|H3BN86_HUMAN Methyltransferase-like protein 9 (Fragment) OS=Homo sapiens GN=METTL9 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 389.5 0.0 7.6e-120 2.9e-116 1 231 [. 16 243 .] 16 243 .] 1.00 Alignments for each domain: == domain 1 score: 389.5 bits; conditional E-value: 7.6e-120 DREV 1 Wyvlnre.lseslqalfvaslpdaetqsflenskklsanlfiqlyhalassilslfmsktdinGllgrGsmfvlseeqfrkllaiek 86 Wyv+nre l+eslqa+fv+s++d++tq+fl+ns+++s++lfiqlyh+++ss++slfms+t+inGllgrGsmfv+s++qf++ll+i+ tr|H3BN86|H3BN86_HUMAN 16 WYVCNREkLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKIN- 101 *************************************************************************************9. PP DREV 87 espasdqedkklldlGaGdGeitkrvaptfeevyatelsetmrdrlkkkkynvlsalelqetdvkldlilclnlldrcfdplklled 173 +d+++++lldlGaGdGe+tk+++p+fee+yatelsetm+++l+kkky+vl+++e+q+t++++d+i+clnlldrc++pl+ll+d tr|H3BN86|H3BN86_HUMAN 102 ----PDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKD 184 ....9********************************************************************************** PP DREV 174 irsalep.ngrvivalvlPvshyvetntgksekpsellevkGrsyeeevarlievlkka 231 irs+lep +grvi+alvlP+++yve+++gk+ekpse+le+kG+++ee+v++l+ev++ka tr|H3BN86|H3BN86_HUMAN 185 IRSVLEPtRGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKA 243 *******9*************************************************97 PP >> tr|H3BM54|H3BM54_HUMAN Methyltransferase-like protein 9 (Fragment) OS=Homo sapiens GN=METTL9 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 245.1 0.0 8e-76 3.1e-72 56 198 .. 1 139 [] 1 139 [] 0.99 Alignments for each domain: == domain 1 score: 245.1 bits; conditional E-value: 8e-76 DREV 56 msktdinGllgrGsmfvlseeqfrkllaiekespasdqedkklldlGaGdGeitkrvaptfeevyatelsetmrdrlkkkkynvlsa 142 ms+t+inGllgrGsmfv+s++qf++ll+i+ +d+++++lldlGaGdGe+tk+++p+fee+yatelsetm+++l+kkky+vl++ tr|H3BM54|H3BM54_HUMAN 1 MSRTSINGLLGRGSMFVFSPDQFQRLLKIN-----PDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGI 82 8****************************9.....9*************************************************** PP DREV 143 lelqetdvkldlilclnlldrcfdplklledirsalep.ngrvivalvlPvshyvet 198 +e+q+t++++d+i+clnlldrc++pl+ll+dirs+lep +grvi+alvlP+++yve+ tr|H3BM54|H3BM54_HUMAN 83 NEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPtRGRVILALVLPFHPYVEN 139 **************************************9****************96 PP >> tr|H3BQD2|H3BQD2_HUMAN Methyltransferase-like protein 9 (Fragment) OS=Homo sapiens GN=METTL9 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 204.6 0.0 1.8e-63 6.9e-60 75 200 .. 2 123 .. 1 127 [. 0.97 Alignments for each domain: == domain 1 score: 204.6 bits; conditional E-value: 1.8e-63 DREV 75 eeqfrkllaiekespasdqedkklldlGaGdGeitkrvaptfeevyatelsetmrdrlkkkkynvlsalelqetdvkldlilclnll 161 ++qf++ll+i+ +d+++++lldlGaGdGe+tk+++p+fee+yatelsetm+++l+kkky+vl+++e+q+t++++d+i+clnll tr|H3BQD2|H3BQD2_HUMAN 2 PDQFQRLLKIN-----PDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLL 83 79********9.....9********************************************************************** PP DREV 162 drcfdplklledirsalep.ngrvivalvlPvshyvetnt 200 drc++pl+ll+dirs+lep +grvi+alvlP+++yve+ tr|H3BQD2|H3BQD2_HUMAN 84 DRCDQPLTLLKDIRSVLEPtRGRVILALVLPFHPYVENGK 123 *******************9*****************965 PP >> tr|H3BPE9|H3BPE9_HUMAN Methyltransferase-like protein 9 (Fragment) OS=Homo sapiens GN=METTL9 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 63.1 0.3 2.7e-20 1e-16 19 66 .. 2 49 .. 1 50 [. 0.97 2 ! 120.0 0.0 1.1e-37 4.4e-34 139 216 .. 47 125 .] 46 125 .] 0.98 Alignments for each domain: == domain 1 score: 63.1 bits; conditional E-value: 2.7e-20 DREV 19 slpdaetqsflenskklsanlfiqlyhalassilslfmsktdinGllg 66 s++d++tq+fl+ns+++s++lfiqlyh+++ss++slfms+t+inG+lg tr|H3BPE9|H3BPE9_HUMAN 2 SYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGVLG 49 79*******************************************997 PP == domain 2 score: 120.0 bits; conditional E-value: 1.1e-37 DREV 139 vlsalelqetdvkldlilclnlldrcfdplklledirsalep.ngrvivalvlPvshyvetntgksekpsellevkGrs 216 vl+++e+q+t++++d+i+clnlldrc++pl+ll+dirs+lep +grvi+alvlP+++yve+++gk+ekpse+le+kG++ tr|H3BPE9|H3BPE9_HUMAN 47 VLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPtRGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQN 125 89****************************************9**********************************96 PP >> tr|B3KU92|B3KU92_HUMAN Putative protein arginine N-methyltransferase 10 OS=Homo sapiens GN=LOC90826 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.3 0.0 1e-05 0.039 83 129 .. 53 100 .. 32 116 .. 0.78 2 ? -3.7 0.0 6.5 2.5e+04 224 259 .. 341 377 .. 338 379 .. 0.78 Alignments for each domain: == domain 1 score: 15.3 bits; conditional E-value: 1e-05 DREV 83 aiekespasdqedkklldlGaGdGeitkrvaptfee.vyatelsetmr 129 + a +k +ld+GaG G ++ ++ + vya els+tm tr|B3KU92|B3KU92_HUMAN 53 YNAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHsVYACELSKTMY 100 444566777778899***********99988776656**********7 PP == domain 2 score: -3.7 bits; conditional E-value: 6.5 DREV 224 liev.lkkagfeveaftrlPylceGdlnnsfyyldda 259 ++ev +++ ++++ l ce d+ +sf +d+ tr|B3KU92|B3KU92_HUMAN 341 MMEVsCQDCYLRIQSISVLGLECEMDVAKSFTQNKDL 377 6676347788899999999999999999999777665 PP >> sp|Q6P2P2|ANM10_HUMAN Putative protein arginine N-methyltransferase 10 OS=Homo sapiens GN=PRMT10 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.0 0.0 1.2e-05 0.048 83 129 .. 166 213 .. 145 228 .. 0.78 Alignments for each domain: == domain 1 score: 15.0 bits; conditional E-value: 1.2e-05 DREV 83 aiekespasdqedkklldlGaGdGeitkrvaptfee.vyatelsetmr 129 + a +k +ld+GaG G ++ ++ + vya els+tm sp|Q6P2P2|ANM10_HUMAN 166 YNAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHsVYACELSKTMY 213 444566777778899***********99988776656**********7 PP >> sp|Q86X55-2|CARM1_HUMAN Isoform 2 of Histone-arginine methyltransferase CARM1 OS=Homo sapiens GN=CARM1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -0.7 0.0 0.81 3.1e+03 96 113 .. 35 52 .. 27 74 .. 0.87 2 ? 9.8 0.0 0.00049 1.9 88 127 .. 178 218 .. 171 233 .. 0.81 3 ? -2.2 0.0 2.2 8.5e+03 181 241 .. 250 310 .. 224 314 .. 0.70 Alignments for each domain: == domain 1 score: -0.7 bits; conditional E-value: 0.81 DREV 96 kklldlGaGdGeitkrva 113 +ll +G +Gei ++ + sp|Q86X55-2|CARM1_HUMAN 35 ARLLTIGDANGEIQRHAE 52 689**********99865 PP == domain 2 score: 9.8 bits; conditional E-value: 0.00049 DREV 88 spasdqedkklldlGaGdGeitkrvapt.feevyatelset 127 + +d++dk +ld+G G G ++ a+ ++ya e+s+ sp|Q86X55-2|CARM1_HUMAN 178 QNHTDFKDKIVLDVGCGSGILSFFAAQAgARKIYAVEASTM 218 567899**************998877652678*****9964 PP == domain 3 score: -2.2 bits; conditional E-value: 2.2 DREV 181 ngrvivalvlPvshyvetntgksekpsellevkGrsyeeevarlievlkkagfeveaftrl 241 + +i++ + ++ + e ++++ +++l+ G+ + + + + + + +e+ft++ sp|Q86X55-2|CARM1_HUMAN 250 QVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKA 310 6677888888888888888888888888888888888766665566666666666777765 PP >> tr|H7C2H9|H7C2H9_HUMAN Protein arginine N-methyltransferase 2 (Fragment) OS=Homo sapiens GN=PRMT2 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.3 0.0 8.3e-05 0.32 90 129 .. 73 114 .. 58 149 .. 0.82 Alignments for each domain: == domain 1 score: 12.3 bits; conditional E-value: 8.3e-05 DREV 90 asdqedkklldlGaGdGeitkrvaptfee..vyatelsetmr 129 + +dk +ld+G G G i+ a + vya e+se + tr|H7C2H9|H7C2H9_HUMAN 73 KESLTDKVILDVGCGTGIISLFCAHYARPraVYAVEASEMAQ 114 4457899*************99998876466******98654 PP >> tr|B7U632|B7U632_HUMAN PRMT2 gamma variant OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.7 0.0 0.00013 0.49 90 129 .. 133 174 .. 119 199 .. 0.81 Alignments for each domain: == domain 1 score: 11.7 bits; conditional E-value: 0.00013 DREV 90 asdqedkklldlGaGdGeitkrvaptfee..vyatelsetmr 129 + +dk +ld+G G G i+ a + vya e+se + tr|B7U632|B7U632_HUMAN 133 KESLTDKVILDVGCGTGIISLFCAHYARPraVYAVEASEMAQ 174 4457899*************99998876466******98654 PP >> tr|A8MXR3|A8MXR3_HUMAN Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.4 0.0 0.00015 0.59 90 129 .. 133 174 .. 119 199 .. 0.81 Alignments for each domain: == domain 1 score: 11.4 bits; conditional E-value: 0.00015 DREV 90 asdqedkklldlGaGdGeitkrvaptfee..vyatelsetmr 129 + +dk +ld+G G G i+ a + vya e+se + tr|A8MXR3|A8MXR3_HUMAN 133 KESLTDKVILDVGCGTGIISLFCAHYARPraVYAVEASEMAQ 174 44578999************99998876466******98654 PP >> sp|Q6UX53|MET7B_HUMAN Methyltransferase-like protein 7B OS=Homo sapiens GN=METTL7B PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.3 0.0 0.00017 0.67 125 182 .. 110 168 .. 53 177 .. 0.75 Alignments for each domain: == domain 1 score: 11.3 bits; conditional E-value: 0.00017 DREV 125 setmrdrlkkkkynvlsale.lqetdvkldlilclnlldrcfdplklledirsalepng 182 s +l+ ++ v + q +d +d+++c +l +p k+l+++r +l+p g sp|Q6UX53|MET7B_HUMAN 110 SMAENRHLQYERFVVAPGEDmRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGG 168 333356799999999998885677899*****************************976 PP >> tr|K7EQA8|K7EQA8_HUMAN Histone-arginine methyltransferase CARM1 (Fragment) OS=Homo sapiens GN=CARM1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.1 0.0 0.0004 1.5 88 127 .. 137 177 .. 130 193 .. 0.80 2 ? -1.9 0.0 1.8 6.9e+03 181 241 .. 209 269 .. 182 273 .. 0.70 Alignments for each domain: == domain 1 score: 10.1 bits; conditional E-value: 0.0004 DREV 88 spasdqedkklldlGaGdGeitkrvapt.feevyatelset 127 + +d++dk +ld+G G G ++ a+ ++ya e+s+ tr|K7EQA8|K7EQA8_HUMAN 137 QNHTDFKDKIVLDVGCGSGILSFFAAQAgARKIYAVEASTM 177 567899**************998877652678*****9964 PP == domain 2 score: -1.9 bits; conditional E-value: 1.8 DREV 181 ngrvivalvlPvshyvetntgksekpsellevkGrsyeeevarlievlkkagfeveaftrl 241 + +i++ + ++ + e ++++ +++l+ G+ + + + + + + +e+ft++ tr|K7EQA8|K7EQA8_HUMAN 209 QVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKA 269 6677888888888888888888888889998888888766665566666666667777766 PP >> sp|P55345-2|ANM2_HUMAN Isoform 2 of Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.2 0.0 0.00019 0.72 90 129 .. 133 174 .. 119 199 .. 0.81 Alignments for each domain: == domain 1 score: 11.2 bits; conditional E-value: 0.00019 DREV 90 asdqedkklldlGaGdGeitkrvaptfee..vyatelsetmr 129 + +dk +ld+G G G i+ a + vya e+se + sp|P55345-2|ANM2_HUMAN 133 KESLTDKVILDVGCGTGIISLFCAHYARPraVYAVEASEMAQ 174 44578999************99998876466******98654 PP >> tr|B7U630|B7U630_HUMAN PRMT2 alpha variant OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.1 0.0 0.00019 0.74 90 129 .. 133 174 .. 119 199 .. 0.81 Alignments for each domain: == domain 1 score: 11.1 bits; conditional E-value: 0.00019 DREV 90 asdqedkklldlGaGdGeitkrvaptfee..vyatelsetmr 129 + +dk +ld+G G G i+ a + vya e+se + tr|B7U630|B7U630_HUMAN 133 KESLTDKVILDVGCGTGIISLFCAHYARPraVYAVEASEMAQ 174 44578999************99998876466******98654 PP >> tr|B7U631|B7U631_HUMAN PRMT2 beta variant OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.0 0.0 0.00021 0.79 90 129 .. 133 174 .. 119 199 .. 0.81 Alignments for each domain: == domain 1 score: 11.0 bits; conditional E-value: 0.00021 DREV 90 asdqedkklldlGaGdGeitkrvaptfee..vyatelsetmr 129 + +dk +ld+G G G i+ a + vya e+se + tr|B7U631|B7U631_HUMAN 133 KESLTDKVILDVGCGTGIISLFCAHYARPraVYAVEASEMAQ 174 34478999************99998876466******98654 PP >> sp|Q86X55-1|CARM1_HUMAN Isoform 1 of Histone-arginine methyltransferase CARM1 OS=Homo sapiens GN=CARM1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.6 0.0 1.5 5.8e+03 96 113 .. 35 52 .. 28 63 .. 0.85 2 ? 9.2 0.0 0.00076 2.9 88 127 .. 178 218 .. 159 233 .. 0.82 Alignments for each domain: == domain 1 score: -1.6 bits; conditional E-value: 1.5 DREV 96 kklldlGaGdGeitkrva 113 +ll +G +Gei ++ + sp|Q86X55-1|CARM1_HUMAN 35 ARLLTIGDANGEIQRHAE 52 689**********99865 PP == domain 2 score: 9.2 bits; conditional E-value: 0.00076 DREV 88 spasdqedkklldlGaGdGeitkrvapt.feevyatelset 127 + +d++dk +ld+G G G ++ a+ ++ya e+s+ sp|Q86X55-1|CARM1_HUMAN 178 QNHTDFKDKIVLDVGCGSGILSFFAAQAgARKIYAVEASTM 218 567899**************998877652678*****9964 PP >> sp|Q86X55|CARM1_HUMAN Histone-arginine methyltransferase CARM1 OS=Homo sapiens GN=CARM1 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.7 0.0 1.6 6.2e+03 96 113 .. 35 52 .. 28 62 .. 0.85 2 ? 9.1 0.0 0.0008 3.1 88 127 .. 178 218 .. 161 234 .. 0.82 Alignments for each domain: == domain 1 score: -1.7 bits; conditional E-value: 1.6 DREV 96 kklldlGaGdGeitkrva 113 +ll +G +Gei ++ + sp|Q86X55|CARM1_HUMAN 35 ARLLTIGDANGEIQRHAE 52 689**********99865 PP == domain 2 score: 9.1 bits; conditional E-value: 0.0008 DREV 88 spasdqedkklldlGaGdGeitkrvapt.feevyatelset 127 + +d++dk +ld+G G G ++ a+ ++ya e+s+ sp|Q86X55|CARM1_HUMAN 178 QNHTDFKDKIVLDVGCGSGILSFFAAQAgARKIYAVEASTM 218 567899**************998877652678*****9964 PP >> sp|P55345-3|ANM2_HUMAN Isoform 3 of Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.8 0.0 0.00024 0.92 90 129 .. 133 174 .. 119 199 .. 0.82 Alignments for each domain: == domain 1 score: 10.8 bits; conditional E-value: 0.00024 DREV 90 asdqedkklldlGaGdGeitkrvaptfee..vyatelsetmr 129 + +dk +ld+G G G i+ a + vya e+se + sp|P55345-3|ANM2_HUMAN 133 KESLTDKVILDVGCGTGIISLFCAHYARPraVYAVEASEMAQ 174 34478999************99998876466******98654 PP >> sp|Q96LA8|ANM6_HUMAN Protein arginine N-methyltransferase 6 OS=Homo sapiens GN=PRMT6 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.5 0.0 0.00031 1.2 89 138 .. 78 127 .. 71 132 .. 0.77 Alignments for each domain: == domain 1 score: 10.5 bits; conditional E-value: 0.00031 DREV 89 pasdqedkklldlGaGdGeitkrvapt.feevyatelsetmrdrlkkkkyn 138 +a+ + k++ld+GaG G ++ a+ +vya e+s ++ + ++n sp|Q96LA8|ANM6_HUMAN 78 WAA-LRGKTVLDVGAGTGILSIFCAQAgARRVYAVEASAIWQQAREVVRFN 127 555.6789************99888762567*******8776665555555 PP >> tr|D6RCL3|D6RCL3_HUMAN Probable dimethyladenosine transferase OS=Homo sapiens GN=DIMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.5 0.0 0.00029 1.1 93 135 .. 55 97 .. 27 125 .. 0.83 Alignments for each domain: == domain 1 score: 10.5 bits; conditional E-value: 0.00029 DREV 93 qedkklldlGaGdGeitkrvaptfeevyatelsetmrdrlkkk 135 + + +l++G G G++t ++ + ++v a el ++ l+k+ tr|D6RCL3|D6RCL3_HUMAN 55 RPTDVVLEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKR 97 446779*****************************99999886 PP >> tr|K7ESL0|K7ESL0_HUMAN Spermidine synthase (Fragment) OS=Homo sapiens GN=SRM PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.4 0.0 0.00032 1.2 57 130 .. 30 105 .. 26 111 .. 0.77 Alignments for each domain: == domain 1 score: 10.4 bits; conditional E-value: 0.00032 DREV 57 sktdinGllgrGsmfvlseeqfrkllaiekespasdqedkklldlGaGdGeitkrv..aptfeevyatelsetmrd 130 skt n l+ G + + f +i + s +++k+l +G GdG + + v p +e v e+ e +++ tr|K7ESL0|K7ESL0_HUMAN 30 SKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVvkHPSVESVVQCEIDEDVIQ 105 56666666677777777778887777788888899999**************998833467999999999888775 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (265 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 1611 (0.0182089); expected 1769.5 (0.02) Passed bias filter: 1287 (0.0145468); expected 1769.5 (0.02) Passed Vit filter: 128 (0.00144677); expected 88.5 (0.001) Passed Fwd filter: 23 (0.000259966); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 23 [number of targets reported over threshold] # CPU time: 0.63u 0.03s 00:00:00.66 Elapsed: 00:00:00.26 # Mc/sec: 35744.95 // [ok]