# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/EMG1.hmm.txt
# target sequence database: proteomes/Homo_sapiens.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: EMG1 [M=194]
Accession: PF03587.13
Description: EMG1/NEP1 methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
7.8e-84 282.4 0.0 9e-84 282.2 0.0 1.0 1 sp|Q92979|NEP1_HUMAN Ribosomal RNA small subunit methyltra
------ inclusion threshold ------
0.3 13.0 0.0 0.37 12.7 0.0 1.1 1 tr|C9JDI3|C9JDI3_HUMAN Troponin C, slow skeletal and cardiac
0.38 12.6 0.4 59 5.5 0.0 2.8 3 tr|J3QLP7|J3QLP7_HUMAN Protein UBBP4 OS=Homo sapiens GN=UBBP
0.4 12.6 0.4 61 5.5 0.0 2.8 3 tr|J3QRK5|J3QRK5_HUMAN Protein UBBP4 OS=Homo sapiens GN=UBBP
0.61 12.0 0.0 0.71 11.8 0.0 1.2 1 tr|H3BTB8|H3BTB8_HUMAN Ubiquitin carboxyl-terminal hydrolase
0.63 11.9 0.0 0.89 11.4 0.0 1.2 1 sp|P63316|TNNC1_HUMAN Troponin C, slow skeletal and cardiac
Domain annotation for each sequence (and alignments):
>> sp|Q92979|NEP1_HUMAN Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens GN=EMG1 PE=1 SV=4
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 282.2 0.0 6.1e-88 9e-84 1 194 [] 45 238 .. 45 238 .. 0.99
Alignments for each domain:
== domain 1 score: 282.2 bits; conditional E-value: 6.1e-88
EEEEEES--B--GGSCGGSB--HHHHCGG.TTSTTGGGSS-CHHHHHHHHHHHCSCHHCTT-EEEEEEETTSEEEEE-TT----SSHHH CS
EMG1 1 ivLeeasLelvkvkkkseqLLnsddhkkilkklkreakeaRpDIvHqcLlalldspLnkagllqvyihttknvlIevnpqtRiPrtfkr 89
+vLe asLe+vkv+ k+++LLn+d+hk+il k++r++ eaRpDI+Hq+Ll+l+dspLn+agllqvyiht+knvlIevnpqtRiPrtf+r
sp|Q92979|NEP1_HUMAN 45 VVLEGASLETVKVG-KTYELLNCDKHKSILLKNGRDPGEARPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDR 132
8************9.************************************************************************** PP
HHHHHHHHHCCSEEEETTEE.SCEEEECS-HHHHCCC-SEEEEE-TTSEE-...............EEEE-SSSS....---HHEEESS CS
EMG1 90 FagLmvqLLkklsirategeekLlkviknpitdhlppgskiillsesaekklvdleefv..vkpvvfvigamskgsvkidykeeeisis 176
F+gLmvqLL+kls+ra++g++kLlkviknp++dh+p g+ ++++s+s + ++ d++e+v ++p+vfv+ga+++g+v+++y+e+++sis
sp|Q92979|NEP1_HUMAN 133 FCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKVGTSFSIP-VVSDVRELVpsSDPIVFVVGAFAHGKVSVEYTEKMVSIS 220
*************************************************.888******9999************************** PP
SS---HHHHHHHHHHHCH CS
EMG1 177 nypLsaavvcskiltafE 194
nypLsaa++c+k++tafE
sp|Q92979|NEP1_HUMAN 221 NYPLSAALTCAKLTTAFE 238
*****************8 PP
>> tr|C9JDI3|C9JDI3_HUMAN Troponin C, slow skeletal and cardiac muscles (Fragment) OS=Homo sapiens GN=TNNC1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.7 0.0 2.5e-05 0.37 87 140 .. 30 84 .. 25 97 .. 0.85
Alignments for each domain:
== domain 1 score: 12.7 bits; conditional E-value: 2.5e-05
HHHHHHHHHHHHCCSEEEETTEE..SCEEEECS-HHHHCCC-SEEEEE-TTSEE- CS
EMG1 87 fkrFagLmvqLLkklsiratege.ekLlkviknpitdhlppgskiillsesaekk 140
f++F +mv ++k+ s ++e+e + L+++ +++ +++ ++ +i+l+ ++e+
tr|C9JDI3|C9JDI3_HUMAN 30 FDEFLVMMVRCMKDDSKGKSEEElSDLFRMFDKNADGYIDLDELKIMLQATGETI 84
99***********977766666559*************************99954 PP
>> tr|J3QLP7|J3QLP7_HUMAN Protein UBBP4 OS=Homo sapiens GN=UBBP4 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -0.6 0.0 0.29 4.3e+03 64 79 .. 2 19 .. 1 25 [. 0.75
2 ? 5.5 0.0 0.004 59 55 77 .. 69 91 .. 64 99 .. 0.82
3 ? 3.8 0.0 0.013 1.9e+02 56 77 .. 146 167 .. 141 175 .. 0.81
Alignments for each domain:
== domain 1 score: -0.6 bits; conditional E-value: 0.29
EEEEEETTSEEE..EE-T CS
EMG1 64 qvyihttknvlI..evnp 79
+++++t ++++I ev+p
tr|J3QLP7|J3QLP7_HUMAN 2 RIFVKTLTGKIItlEVEP 19
89********99334555 PP
== domain 2 score: 5.5 bits; conditional E-value: 0.004
SCHHCTT-EEEEEEETTSEEEEE CS
EMG1 55 spLnkagllqvyihttknvlIev 77
+L ++g +q++++t +++ I++
tr|J3QLP7|J3QLP7_HUMAN 69 LVLRRRGGMQIFVKTLTGKTITL 91
57999************999965 PP
== domain 3 score: 3.8 bits; conditional E-value: 0.013
CHHCTT-EEEEEEETTSEEEEE CS
EMG1 56 pLnkagllqvyihttknvlIev 77
+L +g +q++++t +++ I++
tr|J3QLP7|J3QLP7_HUMAN 146 VLRLRGGMQIFVKTLTGKTITL 167
688899*********9999965 PP
>> tr|J3QRK5|J3QRK5_HUMAN Protein UBBP4 OS=Homo sapiens GN=UBBP4 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -0.6 0.0 0.3 4.4e+03 64 79 .. 2 19 .. 1 25 [. 0.75
2 ? 5.5 0.0 0.0041 61 55 77 .. 69 91 .. 64 99 .. 0.82
3 ? 3.8 0.0 0.013 2e+02 56 77 .. 146 167 .. 141 175 .. 0.81
Alignments for each domain:
== domain 1 score: -0.6 bits; conditional E-value: 0.3
EEEEEETTSEEE..EE-T CS
EMG1 64 qvyihttknvlI..evnp 79
+++++t ++++I ev+p
tr|J3QRK5|J3QRK5_HUMAN 2 RIFVKTLTGKIItlEVEP 19
89********99334555 PP
== domain 2 score: 5.5 bits; conditional E-value: 0.0041
SCHHCTT-EEEEEEETTSEEEEE CS
EMG1 55 spLnkagllqvyihttknvlIev 77
+L ++g +q++++t +++ I++
tr|J3QRK5|J3QRK5_HUMAN 69 LVLRRRGGMQIFVKTLTGKTITL 91
57999************999965 PP
== domain 3 score: 3.8 bits; conditional E-value: 0.013
CHHCTT-EEEEEEETTSEEEEE CS
EMG1 56 pLnkagllqvyihttknvlIev 77
+L +g +q++++t +++ I++
tr|J3QRK5|J3QRK5_HUMAN 146 VLRLRGGMQIFVKTLTGKTITL 167
688899*********9999965 PP
>> tr|H3BTB8|H3BTB8_HUMAN Ubiquitin carboxyl-terminal hydrolase CYLD (Fragment) OS=Homo sapiens GN=CYLD PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.8 0.0 4.8e-05 0.71 94 131 .. 21 57 .. 18 128 .. 0.71
Alignments for each domain:
== domain 1 score: 11.8 bits; conditional E-value: 4.8e-05
HHHHHCCSEEEETTEE.SCEEEECS-HHHHCCC-SEEE CS
EMG1 94 mvqLLkklsirategeekLlkviknpitdhlppgskii 131
+ LL++ s+++++ + kLlkv k +i ++++++s
tr|H3BTB8|H3BTB8_HUMAN 21 FYLLLQECSVTDKQTQ-KLLKVPKGSIGQYIQDRSVGH 57
5679********9988.**************9954333 PP
>> sp|P63316|TNNC1_HUMAN Troponin C, slow skeletal and cardiac muscles OS=Homo sapiens GN=TNNC1 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.4 0.0 6e-05 0.89 87 140 .. 74 128 .. 71 156 .. 0.83
Alignments for each domain:
== domain 1 score: 11.4 bits; conditional E-value: 6e-05
HHHHHHHHHHHHCCSEEEETTEE..SCEEEECS-HHHHCCC-SEEEEE-TTSEE- CS
EMG1 87 fkrFagLmvqLLkklsiratege.ekLlkviknpitdhlppgskiillsesaekk 140
f++F +mv ++k+ s ++e+e + L+++ +++ +++ ++ +i+l+ ++e+
sp|P63316|TNNC1_HUMAN 74 FDEFLVMMVRCMKDDSKGKSEEElSDLFRMFDKNADGYIDLDELKIMLQATGETI 128
99***********977766666559*************************99954 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (194 nodes)
Target sequences: 88473 (35070517 residues searched)
Passed MSV filter: 2183 (0.0246742); expected 1769.5 (0.02)
Passed bias filter: 1506 (0.0170221); expected 1769.5 (0.02)
Passed Vit filter: 104 (0.0011755); expected 88.5 (0.001)
Passed Fwd filter: 6 (6.78173e-05); expected 0.9 (1e-05)
Initial search space (Z): 88473 [actual number of targets]
Domain search space (domZ): 6 [number of targets reported over threshold]
# CPU time: 0.51u 0.02s 00:00:00.53 Elapsed: 00:00:00.21
# Mc/sec: 32398.48
//
[ok]