# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Fibrillarin.hmm.txt
# target sequence database: proteomes/Trypanosoma_brucei.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Fibrillarin [M=226]
Accession: PF01269.17
Description: Fibrillarin
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
7.3e-103 341.5 0.0 8.5e-103 341.3 0.0 1.0 1 tr|Q38AL4|Q38AL4_TRYB2 Fibrillarin OS=Trypanosoma brucei bru
5.4e-100 332.1 0.0 6.3e-100 331.9 0.0 1.0 1 tr|Q388C9|Q388C9_TRYB2 Fibrillarin, putative OS=Trypanosoma
1.4e-98 327.5 0.0 1.5e-98 327.4 0.0 1.0 1 tr|Q388E0|Q388E0_TRYB2 Fibrillarin, putative OS=Trypanosoma
0.0026 15.8 0.0 0.69 7.9 0.0 2.1 2 tr|Q383B4|Q383B4_TRYB2 tRNA (adenine(58)-N(1))-methyltransfe
------ inclusion threshold ------
0.024 12.7 0.0 0.036 12.1 0.0 1.2 1 tr|Q389X8|Q389X8_TRYB2 Uncharacterized protein OS=Trypanosom
Domain annotation for each sequence (and alignments):
>> tr|Q38AL4|Q38AL4_TRYB2 Fibrillarin OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.6k15.3160
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 341.3 0.0 5e-106 8.5e-103 1 225 [. 62 292 .. 62 293 .. 0.98
Alignments for each domain:
== domain 1 score: 341.3 bits; conditional E-value: 5e-106
EEEECSSTTEEEEETTSSEEEEEE-SSTT--SSSSEEEEETTE.......EEEEE-TTTSHHHHHHHTT-S--S--TTSEEEEESTT CS
Fibrillarin 1 veeheklegvyivkekgdarlatknlvpgekvYgEklikveee.......EyRvWnpfrsKlaaailkglkelpikkgskvLYlGaa 80
ve+h + gv+i k+k+d+ l+t n+vpg +vYgEk+++v+ + EyR Wnp+rsKlaaai++g+ ++++k+gskvLYlGaa
tr|Q38AL4|Q38AL4_TRYB2 62 VEPHLLHPGVFISKGKADS-LCTLNMVPGVSVYGEKRVEVGATqsgdekkEYRLWNPYRSKLAAAIYAGVGSIHMKPGSKVLYLGAA 147
688999*********9999.********************9989999999************************************* PP
TSHHHHHHHHHHTTTSEEEEEESSHHHHHHHHHHHTTSTTEEEEES-TTSGGGGTTTS--EEEEEEESSSTTHHHHHHHHHHHHEEE CS
Fibrillarin 81 sGttvsHvsDivgeegvvyavefsprvlrelievakkRknivPileDArkPekYralvekvDvifaDvaqpdqarilaknaklflke 167
sGttvsHvsD+vg+eg+vyavefs+r++r+l++++k+R+nivPi+eDAr+P+kYr+l+++vD+if+Dvaqpdqarila+na++flk+
tr|Q38AL4|Q38AL4_TRYB2 148 SGTTVSHVSDLVGPEGMVYAVEFSNRSGRDLVDMSKRRPNIVPIIEDARYPMKYRMLMPMVDCIFMDVAQPDQARILALNAQAFLKN 234
*************************************************************************************** PP
EEEEEEEEEHHHHHSSSSHHHHHHHHHHHHHHTTEEEEEEEE-TTTSTTEEEEEEEEE CS
Fibrillarin 168 ggyllisikarsidvtkepeevfkeeveklkeeglkvleqvklepyekdhalvvgkyk 225
gg+++isika++id+t ++ v ++e +kl++++lk+leq +lep+e+dha+vvg+y+
tr|Q38AL4|Q38AL4_TRYB2 235 GGHYVISIKANCIDSTLDAPVVIAAELDKLRKDRLKPLEQASLEPFERDHAVVVGVYR 292
*******************************************************997 PP
>> tr|Q388C9|Q388C9_TRYB2 Fibrillarin, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 331.9 0.0 3.7e-103 6.3e-100 2 225 .. 72 300 .. 71 301 .. 0.96
Alignments for each domain:
== domain 1 score: 331.9 bits; conditional E-value: 3.7e-103
EEECSSTTEEEEETTSSEEEEEE-SSTT--SSSSEEEEETTE......EEEEE-TTTSHHHHHHHTT-S--S--TTSEEEEESTTTS CS
Fibrillarin 2 eeheklegvyivkekgdarlatknlvpgekvYgEklikveee......EyRvWnpfrsKlaaailkglkelpikkgskvLYlGaasG 82
++h++++g+y++ +k+ +latk+lvpg ++YgEk+++ + E+RvWnp+rsKlaaai++g++++++++gs vLYlGaasG
tr|Q388C9|Q388C9_TRYB2 72 QPHARMRGCYLLAGKD--TLATKSLVPGVSIYGEKRVSGTIAgetescEFRVWNPYRSKLAAAIYAGVAQIYMEPGSTVLYLGAASG 156
799*********9753..48*****************87655667899*************************************** PP
HHHHHHHHHHTTTSEEEEEESSHHHHHHHHHHHTTSTTEEEEES-TTSGGGGTTTS-.-EEEEEEESSSTTHHHHHHHHHHHHEEEE CS
Fibrillarin 83 ttvsHvsDivgeegvvyavefsprvlrelievakkRknivPileDArkPekYralve.kvDvifaDvaqpdqarilaknaklflkeg 168
ttvsHvsD+vg+egvvyavefs+r++r+l e++k+R+nivPileDAr+P+kYr+l++ vD+if+Dvaqpdqarila+na++flk++
tr|Q388C9|Q388C9_TRYB2 157 TTVSHVSDLVGPEGVVYAVEFSHRSGRDLEEMSKRRSNIVPILEDARYPQKYRMLIPrLVDCIFMDVAQPDQARILALNAQHFLKQN 243
********************************************************978**************************** PP
EEEEEEEEHHHHHSSSSHHHHHHHHHHHHHHTTEEEEEEEE-TTTSTTEEEEEEEEE CS
Fibrillarin 169 gyllisikarsidvtkepeevfkeeveklkeeglkvleqvklepyekdhalvvgkyk 225
g ++isika++id+t+++++vf++ev+klk++gl+++eq +lep+e+dha+v+g yk
tr|Q388C9|Q388C9_TRYB2 244 GGFVISIKANCIDSTADSATVFASEVQKLKDSGLRPKEQASLEPFERDHAVVTGYYK 300
******************************************************997 PP
>> tr|Q388E0|Q388E0_TRYB2 Fibrillarin, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 327.4 0.0 8.8e-102 1.5e-98 8 225 .. 2 224 .. 1 225 [. 0.96
Alignments for each domain:
== domain 1 score: 327.4 bits; conditional E-value: 8.8e-102
TTEEEEETTSSEEEEEE-SSTT--SSSSEEEEETTE......EEEEE-TTTSHHHHHHHTT-S--S--TTSEEEEESTTTSHHHHHH CS
Fibrillarin 8 egvyivkekgdarlatknlvpgekvYgEklikveee......EyRvWnpfrsKlaaailkglkelpikkgskvLYlGaasGttvsHv 88
+g+y++ +k +latk+lvpg ++YgEk+++ + E+RvWnp+rsKlaaai++g++++++++gs vLYlGaasGttvsHv
tr|Q388E0|Q388E0_TRYB2 2 RGCYLLAGK--DTLATKSLVPGVSIYGEKRVSGTIAgetescEFRVWNPYRSKLAAAIYAGVAQIYMEPGSTVLYLGAASGTTVSHV 86
688998865..348*****************87655667899********************************************* PP
HHHHTTTSEEEEEESSHHHHHHHHHHHTTSTTEEEEES-TTSGGGGTTTS-.-EEEEEEESSSTTHHHHHHHHHHHHEEEEEEEEEE CS
Fibrillarin 89 sDivgeegvvyavefsprvlrelievakkRknivPileDArkPekYralve.kvDvifaDvaqpdqarilaknaklflkeggyllis 174
sD+vg+egvvyavefs+r++r+l e++k+R+nivPileDAr+P+kYr+l++ vD+if+Dvaqpdqarila+na++flk++g ++is
tr|Q388E0|Q388E0_TRYB2 87 SDLVGPEGVVYAVEFSHRSGRDLEEMSKRRSNIVPILEDARYPQKYRMLIPrLVDCIFMDVAQPDQARILALNAQHFLKQNGGFVIS 173
**************************************************978********************************** PP
EEHHHHHSSSSHHHHHHHHHHHHHHTTEEEEEEEE-TTTSTTEEEEEEEEE CS
Fibrillarin 175 ikarsidvtkepeevfkeeveklkeeglkvleqvklepyekdhalvvgkyk 225
ika++id+t+++++vf++ev+klk++gl+++eq +lep+e+dha+v+g yk
tr|Q388E0|Q388E0_TRYB2 174 IKANCIDSTADSATVFASEVQKLKDSGLRPKEQASLEPFERDHAVVTGYYK 224
************************************************997 PP
>> tr|Q383B4|Q383B4_TRYB2 tRNA (adenine(58)-N(1))-methyltransferase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 7.9 0.0 0.0004 0.69 63 120 .. 157 212 .. 141 216 .. 0.81
2 ! 5.7 0.0 0.0019 3.2 139 194 .. 268 318 .. 254 337 .. 0.78
Alignments for each domain:
== domain 1 score: 7.9 bits; conditional E-value: 0.0004
-S--S--TTSEEEEESTTTSHHHHHHHHHHTTTSEEEEEESSHHHHHHHHHHHTTSTT CS
Fibrillarin 63 lkelpikkgskvLYlGaasGttvsHvsDivgeegvvyavefsprvlrelievakkRkn 120
+ +l +++g++v G++sG+ ++ v ++g+vy+ +f ++ r l + + R+n
tr|Q383B4|Q383B4_TRYB2 157 VFNLRLRPGHRVAEAGTGSGSLTHSLARTVAPDGIVYTYDFHKK--RCLEALQEFRRN 212
667889***************9999****************876..444455555555 PP
== domain 2 score: 5.7 bits; conditional E-value: 0.0019
--EEEEEEESSSTTHHHHHHHHHHHHEEEEEEEEEEEEHHHHHSSSSHHHHHHHHH CS
Fibrillarin 139 ekvDvifaDvaqpdqarilaknaklflkeggyllisikarsidvtkepeevfkeev 194
++vD +f Dv p +++n+ + l+ gg+ ++ + +i+ t+++++ ++
tr|Q383B4|Q383B4_TRYB2 268 HHVDAVFLDVPSPWL---AIDNVLHVLRPGGM--LCTFSPCIEQTQRTAQRLRQAP 318
68***********75...69*********995..5667999999998887776655 PP
>> tr|Q389X8|Q389X8_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.1 0.0 2.1e-05 0.036 75 134 .. 339 396 .. 329 407 .. 0.84
Alignments for each domain:
== domain 1 score: 12.1 bits; conditional E-value: 2.1e-05
EEESTTTSHHHHHHHHHHTTTSEEEEEESSHHHHHHHHHHHTTSTTEEEEES-TTSGGGG CS
Fibrillarin 75 LYlGaasGttvsHvsDivgeegvvyavefsprvlrelievakkRknivPileDArkPekY 134
L lG + v +++++gvvy vef ++ + + + R+n Pil A +P++
tr|Q389X8|Q389X8_TRYB2 339 LPLGGMKEFNMNTVVPLLDDNGVVYPVEFIHHLMARIKSTRGVREN--PILVAAYMPQSL 396
5566666666677788999**************************9..9*****999975 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (226 nodes)
Target sequences: 8561 (4332363 residues searched)
Passed MSV filter: 187 (0.0218432); expected 171.2 (0.02)
Passed bias filter: 155 (0.0181054); expected 171.2 (0.02)
Passed Vit filter: 15 (0.00175213); expected 8.6 (0.001)
Passed Fwd filter: 5 (0.000584044); expected 0.1 (1e-05)
Initial search space (Z): 8561 [actual number of targets]
Domain search space (domZ): 5 [number of targets reported over threshold]
# CPU time: 0.08u 0.00s 00:00:00.08 Elapsed: 00:00:00.04
# Mc/sec: 24477.85
//
[ok]