# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/FtsJ.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: FtsJ [M=177] Accession: PF01728.18 Description: FtsJ-like methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 2.2e-68 232.1 0.1 2.7e-68 231.8 0.1 1.1 1 sp|Q9UET6-2|TRM7_HUMAN Isoform 2 of Putative tRNA (cytidine 2.2e-68 232.1 0.1 2.7e-68 231.8 0.1 1.1 1 sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosin 1.7e-55 190.1 0.0 3.2e-55 189.2 0.0 1.5 1 sp|Q8IY81|SPB1_HUMAN pre-rRNA processing protein FTSJ3 OS 1.8e-52 180.3 0.0 2.2e-52 180.0 0.0 1.1 1 sp|Q9UI43|RRMJ2_HUMAN Putative ribosomal RNA methyltransfe 8.5e-38 132.5 0.0 9.6e-38 132.3 0.0 1.0 1 tr|J3KS36|J3KS36_HUMAN pre-rRNA-processing protein FTSJ3 (F 1.2e-36 128.8 0.0 2.4e-36 127.7 0.0 1.6 1 sp|Q8N1G2|CMTR1_HUMAN Cap-specific mRNA (nucleoside-2'-O-) 4.9e-32 113.7 0.0 5.6e-32 113.5 0.0 1.0 1 tr|E9PGN6|E9PGN6_HUMAN Putative ribosomal RNA methyltransfe 1.5e-30 108.9 0.1 4.8e-28 100.7 0.0 2.3 2 sp|Q8IYT2|CMTR2_HUMAN Cap-specific mRNA (nucleoside-2'-O-) 2.6e-27 98.3 0.0 3e-27 98.1 0.0 1.0 1 tr|J3QSE2|J3QSE2_HUMAN pre-rRNA-processing protein FTSJ3 (F 1.1e-24 89.8 0.0 1.5e-24 89.3 0.0 1.2 1 tr|Q5T7F5|Q5T7F5_HUMAN Cap-specific mRNA (nucleoside-2'-O-) 3.8e-16 62.0 0.0 4.9e-16 61.6 0.0 1.2 1 tr|E7ETL2|E7ETL2_HUMAN Putative ribosomal RNA methyltransfe 8.8e-16 60.8 0.1 1.1e-15 60.4 0.1 1.1 1 tr|B7Z4K4|B7Z4K4_HUMAN Putative tRNA (cytidine(32)/guanosin 6.8e-12 48.1 0.1 7.9e-12 47.9 0.1 1.1 1 tr|J3KS74|J3KS74_HUMAN pre-rRNA-processing protein FTSJ3 OS 1.7e-06 30.5 0.0 3.7e-06 29.4 0.0 1.5 1 sp|Q8TEA1|NSUN6_HUMAN Putative methyltransferase NSUN6 OS= 0.0049 19.2 0.0 0.011 18.1 0.0 1.5 1 sp|P46087-3|NOP2_HUMAN Isoform 3 of Putative ribosomal RNA 0.0062 18.9 0.0 0.0095 18.3 0.0 1.3 1 sp|Q96CB9-4|NSUN4_HUMAN Isoform 4 of 5-methylcytosine rRNA m 0.0076 18.6 0.0 0.013 17.8 0.0 1.4 1 sp|P46087-2|NOP2_HUMAN Isoform 2 of Putative ribosomal RNA 0.0076 18.6 0.0 0.013 17.8 0.0 1.4 1 sp|P46087|NOP2_HUMAN Putative ribosomal RNA methyltransfe 0.0083 18.5 0.0 0.014 17.8 0.0 1.3 1 sp|Q96CB9|NSUN4_HUMAN 5-methylcytosine rRNA methyltransfer 0.0083 18.5 0.0 0.016 17.5 0.0 1.4 1 sp|P46087-4|NOP2_HUMAN Isoform 4 of Putative ribosomal RNA ------ inclusion threshold ------ 0.011 18.1 0.1 0.04 16.3 0.0 2.0 1 sp|O60678-2|ANM3_HUMAN Isoform 2 of Protein arginine N-meth 0.012 18.0 0.0 0.02 17.3 0.0 1.3 1 sp|Q96P11-5|NSUN5_HUMAN Isoform 5 of Putative methyltransfer 0.014 17.8 0.0 0.024 17.0 0.0 1.3 1 sp|Q96P11|NSUN5_HUMAN Putative methyltransferase NSUN5 OS= 0.016 17.6 0.0 0.028 16.8 0.0 1.4 1 sp|Q96P11-4|NSUN5_HUMAN Isoform 4 of Putative methyltransfer 0.016 17.6 0.1 0.05 16.0 0.0 1.9 1 sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 0.016 17.6 0.0 0.028 16.8 0.0 1.3 1 sp|Q96P11-2|NSUN5_HUMAN Isoform 2 of Putative methyltransfer 0.019 17.4 0.0 0.066 15.6 0.0 1.8 1 sp|Q9H649|NSUN3_HUMAN Putative methyltransferase NSUN3 OS= 0.035 16.5 0.1 0.1 14.9 0.1 1.8 1 tr|M0R299|M0R299_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.044 16.2 0.1 0.13 14.7 0.1 1.8 1 tr|M0QXL5|M0QXL5_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.064 15.6 0.0 0.17 14.2 0.0 1.7 1 tr|M0R2Q4|M0R2Q4_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.07 15.5 0.0 0.13 14.6 0.0 1.4 1 sp|Q08J23-2|NSUN2_HUMAN Isoform 2 of tRNA (cytosine(34)-C(5) 0.074 15.4 0.0 0.14 14.5 0.0 1.4 1 sp|Q08J23|NSUN2_HUMAN tRNA (cytosine(34)-C(5))-methyltrans 0.087 15.2 0.0 0.15 14.4 0.0 1.5 1 tr|M0R0P1|M0R0P1_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.088 15.2 0.1 0.23 13.8 0.1 1.7 1 sp|P22087|FBRL_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.14 14.5 0.0 0.25 13.7 0.0 1.4 1 tr|H3BTZ7|H3BTZ7_HUMAN Protein CMTR2 (Fragment) OS=Homo sap 0.15 14.4 0.0 0.16 14.3 0.0 1.0 1 tr|D6RFG2|D6RFG2_HUMAN 3-hydroxybutyrate dehydrogenase type 0.17 14.2 0.0 0.17 14.2 0.0 1.1 1 tr|D6R9U8|D6R9U8_HUMAN 3-hydroxybutyrate dehydrogenase type 0.18 14.2 0.0 0.18 14.2 0.0 1.1 1 tr|D6RIR6|D6RIR6_HUMAN 3-hydroxybutyrate dehydrogenase type 0.19 14.1 0.0 0.21 14.0 0.0 1.2 1 sp|Q9BUT1-2|BDH2_HUMAN Isoform 2 of 3-hydroxybutyrate dehyd 0.21 14.0 0.0 0.33 13.3 0.0 1.3 1 sp|Q9BVS5|TR61B_HUMAN tRNA (adenine(58)-N(1))-methyltransf 0.21 14.0 0.1 0.61 12.4 0.1 1.7 1 tr|B7Z972|B7Z972_HUMAN Protein-L-isoaspartate O-methyltrans 0.25 13.7 0.0 0.45 12.9 0.0 1.4 1 tr|H3BR19|H3BR19_HUMAN Protein CMTR2 (Fragment) OS=Homo sap 0.31 13.4 0.1 0.88 11.9 0.1 1.7 1 sp|P22061|PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) 0.31 13.4 0.0 0.91 11.9 0.0 1.7 1 sp|P22061-2|PIMT_HUMAN Isoform 2 of Protein-L-isoaspartate( 0.43 12.9 0.0 0.51 12.7 0.0 1.1 1 tr|C9J0F2|C9J0F2_HUMAN Protein-L-isoaspartate(D-aspartate) 0.46 12.8 0.0 0.74 12.2 0.0 1.2 1 tr|F8WDR2|F8WDR2_HUMAN tRNA (adenine(58)-N(1))-methyltransf 0.5 12.7 0.0 0.61 12.4 0.0 1.3 1 sp|Q9BUT1|BDH2_HUMAN 3-hydroxybutyrate dehydrogenase type 0.52 12.7 0.1 1.5 11.2 0.1 1.7 1 tr|J3KP72|J3KP72_HUMAN Protein-L-isoaspartate O-methyltrans 0.52 12.7 0.1 1.5 11.1 0.1 1.7 1 tr|H7BY58|H7BY58_HUMAN Protein-L-isoaspartate O-methyltrans 0.67 12.3 0.0 0.88 11.9 0.0 1.2 1 tr|E9PQ06|E9PQ06_HUMAN Short-chain dehydrogenase/reductase 1.1 11.6 0.0 2.2 10.6 0.0 1.6 1 sp|Q96LA8|ANM6_HUMAN Protein arginine N-methyltransferase Domain annotation for each sequence (and alignments): >> sp|Q9UET6-2|TRM7_HUMAN Isoform 2 of Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapien # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 231.8 0.1 1.5e-71 2.7e-68 1 177 [] 21 199 .. 21 199 .. 0.98 Alignments for each domain: == domain 1 score: 231.8 bits; conditional E-value: 1.5e-71 TTSHHHHHHHHHHHHH--S-TT-EEEEES-TT-HHHHHHTTT.....-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHH CS FtsJ 1 yrsRsayKLleidekfklfkpgktvvDlgaaPGgwsqvllqrlga..kgkvvavDlqpmaplpgvttiqgditdpetiekikealse 85 +r+Rsa+KLl++d++f+lf+ ++++vDl+aaPG+wsqvl+q++g +g+vvavDlq maplpgv +iqgdit+ +t+++i +++++ sp|Q9UET6-2|TRM7_HUMAN 21 WRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLSQKIGGqgSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKG 107 79*****************************************66556*************************************** PP SSEEEEEE-------S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE-STTHHHHHHHHGGGEEEEEEE----------EEEE CS FtsJ 86 rkvdlvvsDgapdvsgvhdldeylqsqLllaalelalkllkpggtfvlkifrgeeteallkqlkkfFekvsvvkPkssrsesseefl 172 ++dlvv+Dgapdv+g hd+dey+q+qLllaal++a+++lkpgg+fv+kifrg++++ l++ql+ fF++v ++kP+ssr++s e+f sp|Q9UET6-2|TRM7_HUMAN 108 CPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAKPRSSRNSSIEAFA 194 *************************************************************************************** PP EEEEE CS FtsJ 173 vcrgf 177 vc+g+ sp|Q9UET6-2|TRM7_HUMAN 195 VCQGY 199 **986 PP >> sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens GN=FTSJ1 PE=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 231.8 0.1 1.6e-71 2.7e-68 1 177 [] 21 199 .. 21 199 .. 0.98 Alignments for each domain: == domain 1 score: 231.8 bits; conditional E-value: 1.6e-71 TTSHHHHHHHHHHHHH--S-TT-EEEEES-TT-HHHHHHTTT.....-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHHSS CS FtsJ 1 yrsRsayKLleidekfklfkpgktvvDlgaaPGgwsqvllqrlga..kgkvvavDlqpmaplpgvttiqgditdpetiekikealserk 87 +r+Rsa+KLl++d++f+lf+ ++++vDl+aaPG+wsqvl+q++g +g+vvavDlq maplpgv +iqgdit+ +t+++i +++++ + sp|Q9UET6|TRM7_HUMAN 21 WRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLSQKIGGqgSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCP 109 79*****************************************66556***************************************** PP EEEEEE-------S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE-STTHHHHHHHHGGGEEEEEEE----------EEEEEEEE CS FtsJ 88 vdlvvsDgapdvsgvhdldeylqsqLllaalelalkllkpggtfvlkifrgeeteallkqlkkfFekvsvvkPkssrsesseeflvcrg 176 +dlvv+Dgapdv+g hd+dey+q+qLllaal++a+++lkpgg+fv+kifrg++++ l++ql+ fF++v ++kP+ssr++s e+f vc+g sp|Q9UET6|TRM7_HUMAN 110 ADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAKPRSSRNSSIEAFAVCQG 198 ***************************************************************************************98 PP E CS FtsJ 177 f 177 + sp|Q9UET6|TRM7_HUMAN 199 Y 199 6 PP >> sp|Q8IY81|SPB1_HUMAN pre-rRNA processing protein FTSJ3 OS=Homo sapiens GN=FTSJ3 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 189.2 0.0 1.9e-58 3.2e-55 1 177 [] 24 200 .. 24 200 .. 0.99 Alignments for each domain: == domain 1 score: 189.2 bits; conditional E-value: 1.9e-58 TTSHHHHHHHHHHHHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHHSSEE CS FtsJ 1 yrsRsayKLleidekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmaplpgvttiqgditdpetiekikealserkvd 89 yrsRsa+KL++++ +f+++++ ++ +Dl+aaPGgw qv+++ + ++ +v+vDl p++plp+v t+q dit+++ ++++++ l+ kvd sp|Q8IY81|SPB1_HUMAN 24 YRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVD 112 9****************99************************999******************************************* PP EEEE-------S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE-STTHHHHHHHHGGGEEEEEEE----------EEEEEEEEE CS FtsJ 90 lvvsDgapdvsgvhdldeylqsqLllaalelalkllkpggtfvlkifrgeeteallkqlkkfFekvsvvkPkssrsesseeflvcrgf 177 +v+ Dgap+v ++ d+y q++L l al+la++ l++gg+f++k+fr+++ + ll ++++F++v+ +kP++sr es+e+f+vc+gf sp|Q8IY81|SPB1_HUMAN 113 VVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQATKPQASRHESAEIFVVCQGF 200 **************************************************************************************98 PP >> sp|Q9UI43|RRMJ2_HUMAN Putative ribosomal RNA methyltransferase 2 OS=Homo sapiens GN=FTSJ2 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 180.0 0.0 1.3e-55 2.2e-52 1 176 [. 52 236 .. 52 237 .. 0.96 Alignments for each domain: == domain 1 score: 180.0 bits; conditional E-value: 1.3e-55 TTSHHHHHHHHHHHHH--S-TT-EEEEES-TT-HHHHHHTTT......-.....SEEEEEESS-----TT-EEE.E--TTSSSHHHHH CS FtsJ 1 yrsRsayKLleidekfklfkpgktvvDlgaaPGgwsqvllqrlga...k.....gkvvavDlqpmaplpgvtti.qgditdpetieki 79 yr+Rsa+KLle++e++++++pg +v+D+gaaPG+wsqv++q+++a + g v++vDl ++ pl+g t++ +d+tdp+t ++i sp|Q9UI43|RRMJ2_HUMAN 52 YRCRSAFKLLEVNERHQILRPGLRVLDCGAAPGAWSQVAVQKVNAagtDpsspvGFVLGVDLLHIFPLEGATFLcPADVTDPRTSQRI 139 9******************************************7765514456799******************99************ PP HHHHHHSSEEEEEE-------S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE-STTHHHHHHHHGGGEEEEEEE--------- CS FtsJ 80 kealserkvdlvvsDgapdvsgvhdldeylqsqLllaalelalkllkpggtfvlkifrgeeteallkqlkkfFekvsvvkPkssrses 167 +e l +r++d+++sD+ap+ +g +dld+ + ++L+l l+++ ++l+pggtf++k++ g+++ +l ++l + F++v+++kP++sr+es sp|Q9UI43|RRMJ2_HUMAN 140 LEVLPGRRADVILSDMAPNATGFRDLDHDRLISLCLTLLSVTPDILQPGGTFLCKTWAGSQSRRLQRRLTEEFQNVRIIKPEASRKES 227 **************************************************************************************** PP -EEEEEEEE CS FtsJ 168 seeflvcrg 176 se+++++++ sp|Q9UI43|RRMJ2_HUMAN 228 SEVYFLATQ 236 *****9987 PP >> tr|J3KS36|J3KS36_HUMAN pre-rRNA-processing protein FTSJ3 (Fragment) OS=Homo sapiens GN=FTSJ3 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 132.3 0.0 5.5e-41 9.6e-38 1 128 [. 24 151 .] 24 151 .] 0.99 Alignments for each domain: == domain 1 score: 132.3 bits; conditional E-value: 5.5e-41 TTSHHHHHHHHHHHHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHHSS CS FtsJ 1 yrsRsayKLleidekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmaplpgvttiqgditdpetiekikealserk 87 yrsRsa+KL++++ +f+++++ ++ +Dl+aaPGgw qv+++ + ++ +v+vDl p++plp+v t+q dit+++ ++++++ l+ k tr|J3KS36|J3KS36_HUMAN 24 YRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWK 110 9****************99************************999***************************************** PP EEEEEE-------S-HHHHHHHHHHHHHHHHHHHHHHEEEE CS FtsJ 88 vdlvvsDgapdvsgvhdldeylqsqLllaalelalkllkpg 128 vd+v+ Dgap+v ++ d+y q++L l al+la++ l++g tr|J3KS36|J3KS36_HUMAN 111 VDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARG 151 ************************************99976 PP >> sp|Q8N1G2|CMTR1_HUMAN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens GN=CMTR1 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 127.7 0.0 1.4e-39 2.4e-36 2 176 .. 233 448 .. 232 449 .. 0.86 Alignments for each domain: == domain 1 score: 127.7 bits; conditional E-value: 1.4e-39 TSHHHHHHHHHHHHH-.-S-TT-E................EEEES-TT-HHHHHHTTT...-SEEEEEES.S--.............. CS FtsJ 2 rsRsayKLleidekfk.lfkpgkt................vvDlgaaPGgwsqvllqrlgakgkvvavDl.qpm.............. 57 +R+a+K++++d f+ +f++ + + D++a+PGg+s+++l+r + ++k ++++l +p+ sp|Q8N1G2|CMTR1_HUMAN 233 LNRAAMKMANMDFVFDrMFTNPRDsygkplvkdreaellyFADVCAGPGGFSEYVLWRKKWHAKGFGMTLkGPNdfkledfysassel 320 68*************8677633224667777777788888******************75589*******888887776666655544 PP .---TT-EEE..E--TTSSSHHHHHHHHHHH....SSEEEEEE-------S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE-. CS FtsJ 58 .aplpgvtti..qgditdpetiekikealse....rkvdlvvsDgapdvsgvhdldeylqsqLllaalelalkllkpggtfvlkifr. 137 +p g i gdit+pe+i ++++++ + ++v++ ++Dg+++v+g+++l+e+l+ qLll+++ +al+++++gg+f++k+f+ sp|Q8N1G2|CMTR1_HUMAN 321 fEPYYGEGGIdgDGDITRPENISAFRNFVLDntdrKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDl 408 444445555599***********99876666666699*************************************************** PP STTHH.HHHHHHGGGEEEEEEE----------EEEEEEEE CS FtsJ 138 geete.allkqlkkfFekvsvvkPkssrsesseeflvcrg 176 ++ ++ +l++ l ++Fe+v ++kP +sr+++se+++vc+g sp|Q8N1G2|CMTR1_HUMAN 409 FTPFSvGLVYLLYCCFERVCLFKPITSRPANSERYVVCKG 448 999999********************************97 PP >> tr|E9PGN6|E9PGN6_HUMAN Putative ribosomal RNA methyltransferase 2 OS=Homo sapiens GN=FTSJ2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 113.5 0.0 3.2e-35 5.6e-32 48 176 .. 13 142 .. 5 143 .. 0.97 Alignments for each domain: == domain 1 score: 113.5 bits; conditional E-value: 3.2e-35 EEEEEESS-----TT-EEE.E--TTSSSHHHHHHHHHHHSSEEEEEE-------S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEE CS FtsJ 48 kvvavDlqpmaplpgvtti.qgditdpetiekikealserkvdlvvsDgapdvsgvhdldeylqsqLllaalelalkllkpggtfvl 133 v++vDl ++ pl+g t++ +d+tdp+t ++i+e l +r++d+++sD+ap+ +g +dld+ + ++L+l l+++ ++l+pggtf++ tr|E9PGN6|E9PGN6_HUMAN 13 FVLGVDLLHIFPLEGATFLcPADVTDPRTSQRILEVLPGRRADVILSDMAPNATGFRDLDHDRLISLCLTLLSVTPDILQPGGTFLC 99 699****************99****************************************************************** PP EEE-STTHHHHHHHHGGGEEEEEEE----------EEEEEEEE CS FtsJ 134 kifrgeeteallkqlkkfFekvsvvkPkssrsesseeflvcrg 176 k++ g+++ +l ++l + F++v+++kP++sr+esse+++++++ tr|E9PGN6|E9PGN6_HUMAN 100 KTWAGSQSRRLQRRLTEEFQNVRIIKPEASRKESSEVYFLATQ 142 ***************************************9987 PP >> sp|Q8IYT2|CMTR2_HUMAN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 OS=Homo sapiens GN=CMTR2 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 100.7 0.0 2.8e-31 4.8e-28 3 176 .. 112 319 .. 110 320 .. 0.85 2 ? 6.0 0.0 0.034 60 98 175 .. 611 689 .. 584 691 .. 0.88 Alignments for each domain: == domain 1 score: 100.7 bits; conditional E-value: 2.8e-31 SHHHHHHHHHHHHH--S-TT......-EEEEES-TT-HHHHHHTTT........-SEEEEEESS--...........---TT-EEE.. CS FtsJ 3 sRsayKLleidekfklfkpg......ktvvDlgaaPGgwsqvllqrlga.....kgkvvavDlqpm...........aplpgvtti.. 66 +++++K ei+ f l+ ++ + ++l+ aPG+++ l++ l+ ++ +va +l+p+ + sp|Q8IYT2|CMTR2_HUMAN 112 TQAWCKFHEILCSFPLIPQEafqngkLNSLHLCEAPGAFIASLNHYLKShrfpcHWSWVANTLNPYheanddlmmimD-------Drl 192 5799999999999997743323333345******************965545445***********776665544441.......033 PP ..............E--TTSSSHHHHHHHHHHH.SSEEEEEE-------S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE-.S CS FtsJ 67 ..............qgditdpetiekikealse.rkvdlvvsDgapdvsgvhdldeylqsqLllaalelalkllkpggtfvlkifr.g 138 +gdi++ + +++++s + v+lv++Dg++d++g+ +e+l s+L + + +al++l++gg+fvlk+f+ + sp|Q8IYT2|CMTR2_HUMAN 193 iantlhwwyfgpdnTGDIMTLKFLTGLQNFISSmATVHLVTADGSFDCQGNPGEQEALVSSLHYCEVVTALTTLGNGGSFVLKMFTmF 280 34445677999************9999999888788***************************************************9 PP TTHH.HHHHHHGGGEEEEEEE----------EEEEEEEE CS FtsJ 139 eete.allkqlkkfFekvsvvkPkssrsesseeflvcrg 176 e+++ +l++ l+++F++v+v+kP++s+ ++se+++vc+ sp|Q8IYT2|CMTR2_HUMAN 281 EHCSiNLMYLLNCCFDQVHVFKPATSKAGNSEVYVVCLH 319 ****9********************************86 PP == domain 2 score: 6.0 bits; conditional E-value: 0.034 ---S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE-.STTHH.HHHHHHGGGEEEEEEE----------EEEEEEE CS FtsJ 98 dvsgvhdldeylqsqLllaalelalkllkpggtfvlkifr.geete.allkqlkkfFekvsvvkPkssrsesseeflvcr 175 ++s+ hd d + q +L+l l +l+ l +g++++l ++ ++++ +l+ l ++F+ ++ v P ss + + l+c sp|Q8IYT2|CMTR2_HUMAN 611 SCSLLHDGDPTYQ-RLFLDCLLHSLRELHTGDVMILPVLScFTRFMaGLIFVLHSCFRFITFVCPTSSDPLRTCAVLLCV 689 6888999999999.8***********************99878888799*9****************9887666666665 PP >> tr|J3QSE2|J3QSE2_HUMAN pre-rRNA-processing protein FTSJ3 (Fragment) OS=Homo sapiens GN=FTSJ3 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 98.1 0.0 1.7e-30 3e-27 1 92 [. 24 115 .] 24 115 .] 0.98 Alignments for each domain: == domain 1 score: 98.1 bits; conditional E-value: 1.7e-30 TTSHHHHHHHHHHHHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHHSS CS FtsJ 1 yrsRsayKLleidekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmaplpgvttiqgditdpetiekikealserk 87 yrsRsa+KL++++ +f+++++ ++ +Dl+aaPGgw qv+++ + ++ +v+vDl p++plp+v t+q dit+++ ++++++ l+ k tr|J3QSE2|J3QSE2_HUMAN 24 YRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWK 110 9****************99************************999***************************************** PP EEEEE CS FtsJ 88 vdlvv 92 vd+v+ tr|J3QSE2|J3QSE2_HUMAN 111 VDVVL 115 ***96 PP >> tr|Q5T7F5|Q5T7F5_HUMAN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (Fragment) OS=Homo sapiens GN=CMTR1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 89.3 0.0 8.6e-28 1.5e-24 24 155 .. 216 371 .. 182 372 .] 0.85 Alignments for each domain: == domain 1 score: 89.3 bits; conditional E-value: 8.6e-28 EEEEES-TT-HHHHHHTTT...-SEEEEEES.S--...............---TT-EEE..E--TTSSSHHHHHHHHHHH....SSE CS FtsJ 24 tvvDlgaaPGgwsqvllqrlgakgkvvavDl.qpm...............aplpgvtti..qgditdpetiekikealse....rkv 88 + D++a+PGg+s+++l+r + ++k ++++l +p+ +p g i gdit+pe+i ++++++ + ++v tr|Q5T7F5|Q5T7F5_HUMAN 216 YFADVCAGPGGFSEYVLWRKKWHAKGFGMTLkGPNdfkledfysasselfEPYYGEGGIdgDGDITRPENISAFRNFVLDntdrKGV 302 489****************75589*******888887776666655544444445555599***********99876666666699* PP EEEEE-------S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE-.STTHH.HHHHHHGGGEEEE CS FtsJ 89 dlvvsDgapdvsgvhdldeylqsqLllaalelalkllkpggtfvlkifr.geete.allkqlkkfFekv 155 ++ ++Dg+++v+g+++l+e+l+ qLll+++ +al+++++gg+f++k+f+ ++ ++ +l++ l ++Fe+v tr|Q5T7F5|Q5T7F5_HUMAN 303 HFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDlFTPFSvGLVYLLYCCFERV 371 **************************************************999999***********98 PP >> tr|E7ETL2|E7ETL2_HUMAN Putative ribosomal RNA methyltransferase 2 OS=Homo sapiens GN=FTSJ2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 61.6 0.0 2.8e-19 4.9e-16 1 70 [. 52 120 .. 52 135 .. 0.86 Alignments for each domain: == domain 1 score: 61.6 bits; conditional E-value: 2.8e-19 TTSHHHHHHHHHHHHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----TT-EEEE--T CS FtsJ 1 yrsRsayKLleidekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmaplpgvttiqgdi 70 yr+Rsa+KLle++e++++++pg +v+D+gaaPG+wsqv++q+++a + +v l p + +gv + +++ tr|E7ETL2|E7ETL2_HUMAN 52 YRCRSAFKLLEVNERHQILRPGLRVLDCGAAPGAWSQVAVQKVNA-AGTDGVSLLPRLQCNGVISAHCNL 120 9******************************************88.667777777776667777766665 PP >> tr|B7Z4K4|B7Z4K4_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens GN=FTSJ1 PE # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 60.4 0.1 6.5e-19 1.1e-15 117 177 .] 2 62 .. 1 62 [. 0.98 Alignments for each domain: == domain 1 score: 60.4 bits; conditional E-value: 6.5e-19 HHHHHHHHEEEEEEEEEEEE-STTHHHHHHHHGGGEEEEEEE----------EEEEEEEEE CS FtsJ 117 alelalkllkpggtfvlkifrgeeteallkqlkkfFekvsvvkPkssrsesseeflvcrgf 177 al++a+++lkpgg+fv+kifrg++++ l++ql+ fF++v ++kP+ssr++s e+f vc+g+ tr|B7Z4K4|B7Z4K4_HUMAN 2 ALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAKPRSSRNSSIEAFAVCQGY 62 899*******************************************************986 PP >> tr|J3KS74|J3KS74_HUMAN pre-rRNA-processing protein FTSJ3 OS=Homo sapiens GN=FTSJ3 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 47.9 0.1 4.6e-15 7.9e-12 1 39 [. 24 62 .. 24 66 .. 0.93 Alignments for each domain: == domain 1 score: 47.9 bits; conditional E-value: 4.6e-15 TTSHHHHHHHHHHHHH--S-TT-EEEEES-TT-HHHHHH CS FtsJ 1 yrsRsayKLleidekfklfkpgktvvDlgaaPGgwsqvl 39 yrsRsa+KL++++ +f+++++ ++ +Dl+aaPGgw l tr|J3KS74|J3KS74_HUMAN 24 YRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWFVTL 62 9****************99****************8665 PP >> sp|Q8TEA1|NSUN6_HUMAN Putative methyltransferase NSUN6 OS=Homo sapiens GN=NSUN6 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 29.4 0.0 2.1e-09 3.7e-06 21 149 .. 234 389 .. 223 393 .. 0.77 Alignments for each domain: == domain 1 score: 29.4 bits; conditional E-value: 2.1e-09 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--........---...TT-EEEE--TTSSSHHHHHHHHHHH.....SSEEEEE CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm........apl...pgvttiqgditdpetiekikealse.....rkvdlvv 92 pg++++Dl+aaPGg + ++ ++ +g v+a+D + a+l + ++ ++ d t+ + ++++++ +e + +d ++ sp|Q8TEA1|NSUN6_HUMAN 234 PGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKIFNkvekikqnALLlglNSIRAFCFDGTKAVKLDMVEDTEGEppflpESFDRIL 321 8999*******************999*******9555557666543443444555559999**********98888999998889998 PP E----.......---S-HHHHHHHHH.HHHHHHHHHHHHHEEEEEEEEEEEE-...STTHHHHHHHHG CS FtsJ 93 sDgap.......dvsgvhdldeylqs.qLllaalelalkllkpggtfvlkifr...geeteallkqlk 149 D ++ +++++e+ + L ++ ++ a++llkp+g++v +++ e+ e+++ +l sp|Q8TEA1|NSUN6_HUMAN 322 LDAPCsgmgqrpNMACTWSVKEVASYqPLQRKLFTAAVQLLKPEGVLVYSTCTitlAENEEQVAWALT 389 886423444444777787777777764899******************88777666666667766655 PP >> sp|P46087-3|NOP2_HUMAN Isoform 3 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.1 0.0 6.5e-06 0.011 21 132 .. 380 509 .. 361 522 .. 0.70 Alignments for each domain: == domain 1 score: 18.1 bits; conditional E-value: 6.5e-06 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHH.......SSEEEEEE------- CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmaplpgvttiqgditdpetiekikealse.......rkvdlvvsDgapdvs 100 + ++++D ++aPGg + +++q ++++g+++a D + ++++++ g+ + + ++i + ++ ++d v+ D + + sp|P46087-3|NOP2_HUMAN 380 EHERILDMCCAPGGKTSYMAQLMKNTGVILANDANA----ERLKSVVGNLHRLGVTNTIISHYDGrqfpkvvGGFDRVLLDAPCSGT 462 45679*****************98877777777766....67777777777777777777666665666666557777777665555 PP S-HHHHHHHH...............HHHHHHHHHHHHHHEEEEEEEE CS FtsJ 101 gvhdldeylq...............sqLllaalelalkllkpggtfv 132 gv ++d +++ +Lll+a+ ++ k+gg +v sp|P46087-3|NOP2_HUMAN 463 GVISKDPAVKtnkdekdilrcahlqKELLLSAIDSVNATSKTGGYLV 509 55555555555555555555666655677777776666777777666 PP >> sp|Q96CB9-4|NSUN4_HUMAN Isoform 4 of 5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.3 0.0 5.5e-06 0.0095 19 137 .. 122 262 .. 111 306 .. 0.72 Alignments for each domain: == domain 1 score: 18.3 bits; conditional E-value: 5.5e-06 S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--..---.TT-EEE.E--TTSSSHHHHHH......HHHHHSSEEEEEE- CS FtsJ 19 fkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm..apl.pgvtti.qgditdpetiekik......ealserkvdlvvsD 94 ++pg+ v+Dl+aaPGg + llq g ++ a Dl p a l + ++++ i+d ++ + + l++ d v+ D sp|Q96CB9-4|NSUN4_HUMAN 122 LQPGDIVLDLCAAPGGKTLALLQT-GCCRNLAANDLSPSriARLqKILHSYvPEEIRDGNQVRVTSwdgrkwGELEGDTYDRVLVD 206 578999******************.555889999**99854333343343377777777777633333333344566899999999 PP ------S-HHHHHHHH..................HHHHHHHHHHHHHHEEEEEEEEEEEE- CS FtsJ 95 gapdvsgvhdldeylq..................sqLllaalelalkllkpggtfvlkifr 137 + p+++ +h+l e + +qL l +l kpgg++v ++ sp|Q96CB9-4|NSUN4_HUMAN 207 V-PCTTDRHSLHEEENnifkrsrkkerqilpvlqVQL----LAAGLLATKPGGHVVYSTCS 262 9.58888888888887788887777666533222222....22233456788888866655 PP >> sp|P46087-2|NOP2_HUMAN Isoform 2 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.8 0.0 7.6e-06 0.013 21 132 .. 380 509 .. 300 529 .. 0.78 Alignments for each domain: == domain 1 score: 17.8 bits; conditional E-value: 7.6e-06 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHH.......SSEEEEEE------- CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmaplpgvttiqgditdpetiekikealse.......rkvdlvvsDgapdvs 100 + ++++D ++aPGg + +++q ++++g+++a D + ++++++ g+ + + ++i + ++ ++d v+ D + + sp|P46087-2|NOP2_HUMAN 380 EHERILDMCCAPGGKTSYMAQLMKNTGVILANDANA----ERLKSVVGNLHRLGVTNTIISHYDGrqfpkvvGGFDRVLLDAPCSGT 462 45679*****************98877777777766....67777777777777777777666665666666557777777665555 PP S-HHHHHHHH...............HHHHHHHHHHHHHHEEEEEEEE CS FtsJ 101 gvhdldeylq...............sqLllaalelalkllkpggtfv 132 gv ++d +++ +Lll+a+ ++ k+gg +v sp|P46087-2|NOP2_HUMAN 463 GVISKDPAVKtnkdekdilrcahlqKELLLSAIDSVNATSKTGGYLV 509 65555555555555555555666655777777777667777777666 PP >> sp|P46087|NOP2_HUMAN Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.8 0.0 7.7e-06 0.013 21 132 .. 384 513 .. 304 533 .. 0.78 Alignments for each domain: == domain 1 score: 17.8 bits; conditional E-value: 7.7e-06 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHH.......SSEEEEEE-------S- CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmaplpgvttiqgditdpetiekikealse.......rkvdlvvsDgapdvsgv 102 + ++++D ++aPGg + +++q ++++g+++a D + ++++++ g+ + + ++i + ++ ++d v+ D + +gv sp|P46087|NOP2_HUMAN 384 EHERILDMCCAPGGKTSYMAQLMKNTGVILANDANA----ERLKSVVGNLHRLGVTNTIISHYDGrqfpkvvGGFDRVLLDAPCSGTGV 468 45679*****************98877777777766....6777777777777777777766666566666655777777766555565 PP HHHHHHHH...............HHHHHHHHHHHHHHEEEEEEEE CS FtsJ 103 hdldeylq...............sqLllaalelalkllkpggtfv 132 ++d +++ +Lll+a+ ++ k+gg +v sp|P46087|NOP2_HUMAN 469 ISKDPAVKtnkdekdilrcahlqKELLLSAIDSVNATSKTGGYLV 513 555555555555555555666655777777777667777777666 PP >> sp|Q96CB9|NSUN4_HUMAN 5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.8 0.0 7.8e-06 0.014 19 136 .. 171 310 .. 161 347 .. 0.70 Alignments for each domain: == domain 1 score: 17.8 bits; conditional E-value: 7.8e-06 S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--..---.TT-EEE.E--TTSSSHHHHHH......HHHHHSSEEEEEE--- CS FtsJ 19 fkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm..apl.pgvtti.qgditdpetiekik......ealserkvdlvvsDga 96 ++pg+ v+Dl+aaPGg + llq g ++ a Dl p a l + ++++ i+d ++ + + l++ d v+ D+ sp|Q96CB9|NSUN4_HUMAN 171 LQPGDIVLDLCAAPGGKTLALLQT-GCCRNLAANDLSPSriARLqKILHSYvPEEIRDGNQVRVTSwdgrkwGELEGDTYDRVLVDV- 256 578999******************.555889999**998543333333333677777777776333333333445668999999999. PP ----S-HHHHHHHH..................HHHHHHHHHHHHHHEEEEEEEEEEEE CS FtsJ 97 pdvsgvhdldeylq..................sqLllaalelalkllkpggtfvlkif 136 p+++ +h+l e + +qL l +l kpgg++v ++ sp|Q96CB9|NSUN4_HUMAN 257 PCTTDRHSLHEEENnifkrsrkkerqilpvlqVQL----LAAGLLATKPGGHVVYSTC 310 58888888888887777787777666533222222....2223345678888876665 PP >> sp|P46087-4|NOP2_HUMAN Isoform 4 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.5 0.0 9.5e-06 0.016 21 132 .. 417 546 .. 396 566 .. 0.71 Alignments for each domain: == domain 1 score: 17.5 bits; conditional E-value: 9.5e-06 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHH.......SSEEEEEE------- CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmaplpgvttiqgditdpetiekikealse.......rkvdlvvsDgapdvs 100 + ++++D ++aPGg + +++q ++++g+++a D + ++++++ g+ + + ++i + ++ ++d v+ D + + sp|P46087-4|NOP2_HUMAN 417 EHERILDMCCAPGGKTSYMAQLMKNTGVILANDANA----ERLKSVVGNLHRLGVTNTIISHYDGrqfpkvvGGFDRVLLDAPCSGT 499 45679*****************98877777777766....67777777777777777777666665666666557777777665555 PP S-HHHHHHHH...............HHHHHHHHHHHHHHEEEEEEEE CS FtsJ 101 gvhdldeylq...............sqLllaalelalkllkpggtfv 132 gv ++d +++ +Lll+a+ ++ k+gg +v sp|P46087-4|NOP2_HUMAN 500 GVISKDPAVKtnkdekdilrcahlqKELLLSAIDSVNATSKTGGYLV 546 65555555555555555555666655677777777667777777666 PP >> sp|O60678-2|ANM3_HUMAN Isoform 2 of Protein arginine N-methyltransferase 3 OS=Homo sapiens GN=PRMT3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.3 0.0 2.3e-05 0.04 17 71 .. 190 252 .. 171 329 .. 0.79 Alignments for each domain: == domain 1 score: 16.3 bits; conditional E-value: 2.3e-05 --S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--...........---.TT-EEEE--TT CS FtsJ 17 klfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm...........apl.pgvttiqgdit 71 ++f ++k v+D+g+++G s ++++ ga +kv++vD+ ++ + l + +t+i+g i sp|O60678-2|ANM3_HUMAN 190 HIF-KDKVVLDVGCGTGILSMFAAKA-GA-KKVLGVDQSEIlyqamdiirlnK-LeDTITLIKGKIE 252 556.6789******************.88.9********99886555544422.2355555555553 PP >> sp|Q96P11-5|NSUN5_HUMAN Isoform 5 of Putative methyltransferase NSUN5 OS=Homo sapiens GN=NSUN5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 17.3 0.0 1.1e-05 0.02 21 76 .. 188 254 .. 169 296 .. 0.74 Alignments for each domain: == domain 1 score: 17.3 bits; conditional E-value: 1.1e-05 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--......---...TT-EEE...E--TTSSSHH CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm......apl...pgvtti...qgditdpeti 76 pg +v+D +aaPG+ + l+ l+++gk++a+Dl + l gv++ + d++ + sp|Q96P11-5|NSUN5_HUMAN 188 PGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKrlasmaT-LlarAGVSCCelaEEDFLAVSPS 254 7899*******************999********8775544431.12335665555556666555555 PP >> sp|Q96P11|NSUN5_HUMAN Putative methyltransferase NSUN5 OS=Homo sapiens GN=NSUN5 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 17.0 0.0 1.4e-05 0.024 21 75 .. 226 291 .. 208 325 .. 0.72 Alignments for each domain: == domain 1 score: 17.0 bits; conditional E-value: 1.4e-05 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--......---...TT-EEE...E--TTSSSH CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm......apl...pgvtti...qgditdpet 75 pg +v+D +aaPG+ + l+ l+++gk++a+Dl + l gv++ + d++ + sp|Q96P11|NSUN5_HUMAN 226 PGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKrlasmaT-LlarAGVSCCelaEEDFLAVSP 291 7899*******************999********8774544431.1233555555555666655555 PP >> sp|Q96P11-4|NSUN5_HUMAN Isoform 4 of Putative methyltransferase NSUN5 OS=Homo sapiens GN=NSUN5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.8 0.0 1.6e-05 0.028 21 75 .. 226 291 .. 208 323 .. 0.72 Alignments for each domain: == domain 1 score: 16.8 bits; conditional E-value: 1.6e-05 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--......---...TT-EEE...E--TTSSSH CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm......apl...pgvtti...qgditdpet 75 pg +v+D +aaPG+ + l+ l+++gk++a+Dl + l gv++ + d++ + sp|Q96P11-4|NSUN5_HUMAN 226 PGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKrlasmaT-LlarAGVSCCelaEEDFLAVSP 291 7899*******************999********8774544431.1233555555555666655555 PP >> sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 3 OS=Homo sapiens GN=PRMT3 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.0 0.0 2.9e-05 0.05 17 71 .. 252 314 .. 234 390 .. 0.79 Alignments for each domain: == domain 1 score: 16.0 bits; conditional E-value: 2.9e-05 --S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--...........---.TT-EEEE--TT CS FtsJ 17 klfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm...........apl.pgvttiqgdit 71 ++f ++k v+D+g+++G s ++++ ga +kv++vD+ ++ + l + +t+i+g i sp|O60678|ANM3_HUMAN 252 HIF-KDKVVLDVGCGTGILSMFAAKA-GA-KKVLGVDQSEIlyqamdiirlnK-LeDTITLIKGKIE 314 556.6789******************.88.9********99886555544422.2355555555553 PP >> sp|Q96P11-2|NSUN5_HUMAN Isoform 2 of Putative methyltransferase NSUN5 OS=Homo sapiens GN=NSUN5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.8 0.0 1.6e-05 0.028 21 75 .. 226 291 .. 208 323 .. 0.72 Alignments for each domain: == domain 1 score: 16.8 bits; conditional E-value: 1.6e-05 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--......---...TT-EEE...E--TTSSSH CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm......apl...pgvtti...qgditdpet 75 pg +v+D +aaPG+ + l+ l+++gk++a+Dl + l gv++ + d++ + sp|Q96P11-2|NSUN5_HUMAN 226 PGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKrlasmaT-LlarAGVSCCelaEEDFLAVSP 291 7899*******************999********8774544431.1233555555555666655555 PP >> sp|Q9H649|NSUN3_HUMAN Putative methyltransferase NSUN3 OS=Homo sapiens GN=NSUN3 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.6 0.0 3.8e-05 0.066 20 146 .. 130 277 .. 110 284 .. 0.63 Alignments for each domain: == domain 1 score: 15.6 bits; conditional E-value: 3.8e-05 -TT-EEEEES-TT-HHHHHHTTT..............-SEEEEEESS-----TT-EEEE--TTSSSHHHHHHHHHHHSSEEEEEE--- CS FtsJ 20 kpgktvvDlgaaPGgwsqvllqrl.......ga....kgkvvavDlqpmaplpgvttiqgditdpetiekikealserkvdlvvsDga 96 + g++v+Dl+aaPGg s llq ++ + +++ +l + p p +++i+ +d +++ ++ + +d v+ D sp|Q9H649|NSUN3_HUMAN 130 RDGEKVLDLCAAPGGKSIALLQCAcpgylhcNEydslRLRWLRQTLESFIPQPLINVIKVSELDGRKMGDAQPEM----FDKVLVDAP 213 56789***************9998554444311333448888888888888888888877776666666666644....777777764 PP -.................---S-HHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE-..STTHHHHHH CS FtsJ 97 p.................dvsgvhdldeylqsqLllaalelalkllkpggtfvlkifr..geeteallk 146 +s +++l +lq++Ll++a++ l+pgg++v +++ ++e +++++ sp|Q9H649|NSUN3_HUMAN 214 CsndrswlfssdsqkascRISQRRNL-PLLQIELLRSAIK----ALRPGGILVYSTCTlsKAENQDVIS 277 34555555444333333233332222.2334555555555....4999999998887764333335555 PP >> tr|M0R299|M0R299_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.9 0.1 6e-05 0.1 13 99 .. 67 157 .. 55 211 .. 0.79 Alignments for each domain: == domain 1 score: 14.9 bits; conditional E-value: 6e-05 HHHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--.........---TT-EEEE--TTSSSHHHHHHHHHHHSSEEE CS FtsJ 13 dekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm.........aplpgvttiqgditdpetiekikealserkvdl 90 ++ + +kpg +v+ lgaa G ++ +g++g v+av + +++ ++ + d ++p + +++ vd+ tr|M0R299|M0R299_HUMAN 67 VDQIH-IKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRsgrdlinlaKKRTNIIPVIEDARHPHKYRMLIA-----MVDV 147 57788.89**********************************999788666543344555555*********999885.....49** PP EEE---.--- CS FtsJ 91 vvsDga.pdv 99 + +D+a pd tr|M0R299|M0R299_HUMAN 148 IFADVAqPDQ 157 *****94443 PP >> tr|M0QXL5|M0QXL5_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.7 0.1 7.2e-05 0.13 13 99 .. 90 180 .. 78 232 .. 0.79 Alignments for each domain: == domain 1 score: 14.7 bits; conditional E-value: 7.2e-05 HHHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--.........---TT-EEEE--TTSSSHHHHHHHHHHHSSEEE CS FtsJ 13 dekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm.........aplpgvttiqgditdpetiekikealserkvdl 90 ++ + +kpg +v+ lgaa G ++ +g++g v+av + +++ ++ + d ++p + +++ vd+ tr|M0QXL5|M0QXL5_HUMAN 90 VDQIH-IKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRsgrdlinlaKKRTNIIPVIEDARHPHKYRMLIA-----MVDV 170 57788.89**********************************999788666543344555555*********999885.....49** PP EEE---.--- CS FtsJ 91 vvsDga.pdv 99 + +D+a pd tr|M0QXL5|M0QXL5_HUMAN 171 IFADVAqPDQ 180 *****94443 PP >> tr|M0R2Q4|M0R2Q4_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.2 0.0 9.9e-05 0.17 13 99 .. 128 218 .. 116 265 .. 0.79 Alignments for each domain: == domain 1 score: 14.2 bits; conditional E-value: 9.9e-05 HHHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--.........---TT-EEEE--TTSSSHHHHHHHHHHHSSEEE CS FtsJ 13 dekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm.........aplpgvttiqgditdpetiekikealserkvdl 90 ++ + +kpg +v+ lgaa G ++ +g++g v+av + +++ ++ + d ++p + +++ vd+ tr|M0R2Q4|M0R2Q4_HUMAN 128 VDQIH-IKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRsgrdlinlaKKRTNIIPVIEDARHPHKYRMLIA-----MVDV 208 57788.89**********************************999788666543344555555*********999885.....49** PP EEE---.--- CS FtsJ 91 vvsDga.pdv 99 + +D+a pd tr|M0R2Q4|M0R2Q4_HUMAN 209 IFADVAqPDQ 218 *****94443 PP >> sp|Q08J23-2|NSUN2_HUMAN Isoform 2 of tRNA (cytosine(34)-C(5))-methyltransferase OS=Homo sapiens GN=NSUN2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.6 0.0 7.4e-05 0.13 20 137 .. 140 287 .. 108 304 .. 0.68 Alignments for each domain: == domain 1 score: 14.6 bits; conditional E-value: 7.4e-05 -TT-EEEEES-TT-HHHHHHTTT..........-SEEEEEESS--.........---...TT-EEEE--TTSSSHHH.HHHHHHHH CS FtsJ 20 kpgktvvDlgaaPGgwsqvllqrlga.......kgkvvavDlqpm.........apl...pgvttiqgditdpetie.kikealse 85 +p ++++D +aaPG+ + l + l+a +g v+a D+ + + + p + +++ d + + +++ sp|Q08J23-2|NSUN2_HUMAN 140 RPHHKILDMCAAPGSKTTQLIEMLHAdmnvpfpEGFVIANDVDNKrcyllvhqaK-RlssPCIMVVNHDASSIPRLQiD----VDG 220 57899*******************7766666666********7766788887643.23455555556666555555421....222 PP SS....EEEEEE----........---S-HHHHHHHH......HHHHHHHHHHHH...HHEEEEEEEEEEEE- CS FtsJ 86 rk....vdlvvsDgap........dvsgvhdldeylq......sqLllaalelal...kllkpggtfvlkifr 137 rk d +++D+ + +d ++ +qL +l++a+ ++l++gg +v ++ sp|Q08J23-2|NSUN2_HUMAN 221 RKeilfYDRILCDVPCsgdgtmrkN------IDVWKKwttlnsLQLHGLQLRIATrgaEQLAEGGRMVYSTCS 287 2223338999999854443333433......444444555544788888888877333588899988876665 PP >> sp|Q08J23|NSUN2_HUMAN tRNA (cytosine(34)-C(5))-methyltransferase OS=Homo sapiens GN=NSUN2 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.5 0.0 8.1e-05 0.14 20 137 .. 175 322 .. 143 339 .. 0.68 Alignments for each domain: == domain 1 score: 14.5 bits; conditional E-value: 8.1e-05 -TT-EEEEES-TT-HHHHHHTTT..........-SEEEEEESS--.........---...TT-EEEE--TTSSSHHH.HHHHHHHHSS CS FtsJ 20 kpgktvvDlgaaPGgwsqvllqrlga.......kgkvvavDlqpm.........apl...pgvttiqgditdpetie.kikealserk 87 +p ++++D +aaPG+ + l + l+a +g v+a D+ + + + p + +++ d + + +++rk sp|Q08J23|NSUN2_HUMAN 175 RPHHKILDMCAAPGSKTTQLIEMLHAdmnvpfpEGFVIANDVDNKrcyllvhqaK-RlssPCIMVVNHDASSIPRLQiD----VDGRK 257 57899*******************7766666666********7766788887643.23455555556666555555421....22222 PP ....EEEEEE----........---S-HHHHHHHH......HHHHHHHHHHHH...HHEEEEEEEEEEEE- CS FtsJ 88 ....vdlvvsDgap........dvsgvhdldeylq......sqLllaalelal...kllkpggtfvlkifr 137 d +++D+ + +d ++ +qL +l++a+ ++l++gg +v ++ sp|Q08J23|NSUN2_HUMAN 258 eilfYDRILCDVPCsgdgtmrkN------IDVWKKwttlnsLQLHGLQLRIATrgaEQLAEGGRMVYSTCS 322 23338999999854443333433......444444555544788888888877333588889988876665 PP >> tr|M0R0P1|M0R0P1_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.4 0.0 8.9e-05 0.15 13 98 .. 115 204 .. 103 227 .. 0.80 Alignments for each domain: == domain 1 score: 14.4 bits; conditional E-value: 8.9e-05 HHHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--.........---TT-EEEE--TTSSSHHHHHHHHHHHSSEEE CS FtsJ 13 dekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm.........aplpgvttiqgditdpetiekikealserkvdl 90 ++ + +kpg +v+ lgaa G ++ +g++g v+av + +++ ++ + d ++p + +++ vd+ tr|M0R0P1|M0R0P1_HUMAN 115 VDQIH-IKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRsgrdlinlaKKRTNIIPVIEDARHPHKYRMLIA-----MVDV 195 57788.89**********************************999788666543344555555*********999885.....49** PP EEE---.-- CS FtsJ 91 vvsDga.pd 98 + +D+a pd tr|M0R0P1|M0R0P1_HUMAN 196 IFADVAqPD 204 *****9454 PP >> sp|P22087|FBRL_HUMAN rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens GN=FBL PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.8 0.1 0.00013 0.23 13 99 .. 152 242 .. 140 299 .. 0.79 Alignments for each domain: == domain 1 score: 13.8 bits; conditional E-value: 0.00013 HHHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--.........---TT-EEEE--TTSSSHHHHHHHHHHHSSEEEEE CS FtsJ 13 dekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm.........aplpgvttiqgditdpetiekikealserkvdlvv 92 ++ + +kpg +v+ lgaa G ++ +g++g v+av + +++ ++ + d ++p + +++ vd++ sp|P22087|FBRL_HUMAN 152 VDQIH-IKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRsgrdlinlaKKRTNIIPVIEDARHPHKYRMLIA-----MVDVIF 234 57788.89**********************************999788666543344555555*********999885.....49**** PP E---.--- CS FtsJ 93 sDga.pdv 99 +D+a pd sp|P22087|FBRL_HUMAN 235 ADVAqPDQ 242 ***94443 PP >> tr|H3BTZ7|H3BTZ7_HUMAN Protein CMTR2 (Fragment) OS=Homo sapiens GN=CMTR2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.7 0.0 0.00015 0.25 3 43 .. 112 158 .. 110 160 .] 0.76 Alignments for each domain: == domain 1 score: 13.7 bits; conditional E-value: 0.00015 SHHHHHHHHHHHHH--S-TT......-EEEEES-TT-HHHHHHTTT. CS FtsJ 3 sRsayKLleidekfklfkpg......ktvvDlgaaPGgwsqvllqrl 43 +++++K ei+ f l+ ++ + ++l+ aPG+++ l++ l tr|H3BTZ7|H3BTZ7_HUMAN 112 TQAWCKFHEILCSFPLIPQEafqngkLNSLHLCEAPGAFIASLNHYL 158 579999999*999997743323333345************9999876 PP >> tr|D6RFG2|D6RFG2_HUMAN 3-hydroxybutyrate dehydrogenase type 2 OS=Homo sapiens GN=BDH2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.3 0.0 9.3e-05 0.16 42 85 .. 28 74 .. 5 86 .. 0.73 Alignments for each domain: == domain 1 score: 14.3 bits; conditional E-value: 9.3e-05 T...-SEEEEEESS--.....---TT-EEEE--TTSSSHHHHHHHHHHH CS FtsJ 42 rlgakgkvvavDlqpm.....aplpgvttiqgditdpetiekikealse 85 r +++kv+a D+++ ++ pg++t d+t++++i+++ + +++ tr|D6RFG2|D6RFG2_HUMAN 28 R--EGAKVIATDINESklqelEKYPGIQTRVLDVTKKKQIDQFANEVER 74 2..259********99665444449****************99887654 PP >> tr|D6R9U8|D6R9U8_HUMAN 3-hydroxybutyrate dehydrogenase type 2 (Fragment) OS=Homo sapiens GN=BDH2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.2 0.0 0.0001 0.17 42 85 .. 28 74 .. 5 112 .. 0.73 Alignments for each domain: == domain 1 score: 14.2 bits; conditional E-value: 0.0001 T...-SEEEEEESS--.....---TT-EEEE--TTSSSHHHHHHHHHHH CS FtsJ 42 rlgakgkvvavDlqpm.....aplpgvttiqgditdpetiekikealse 85 r +++kv+a D+++ ++ pg++t d+t++++i+++ + +++ tr|D6R9U8|D6R9U8_HUMAN 28 R--EGAKVIATDINESklqelEKYPGIQTRVLDVTKKKQIDQFANEVER 74 2..259********99665444449****************99987755 PP >> tr|D6RIR6|D6RIR6_HUMAN 3-hydroxybutyrate dehydrogenase type 2 (Fragment) OS=Homo sapiens GN=BDH2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.2 0.0 0.0001 0.18 42 89 .. 28 76 .. 5 127 .. 0.71 Alignments for each domain: == domain 1 score: 14.2 bits; conditional E-value: 0.0001 T...-SEEEEEESS--.....---TT-EEEE--TTSSSHHHHHHHHHHHSSEE CS FtsJ 42 rlgakgkvvavDlqpm.....aplpgvttiqgditdpetiekikealserkvd 89 r +++kv+a D+++ ++ pg++t d+t++++i+++ + +++ d tr|D6RIR6|D6RIR6_HUMAN 28 R--EGAKVIATDINESklqelEKYPGIQTRVLDVTKKKQIDQFANEVER--LD 76 2..259********99665444449****************99987765..33 PP >> sp|Q9BUT1-2|BDH2_HUMAN Isoform 2 of 3-hydroxybutyrate dehydrogenase type 2 OS=Homo sapiens GN=BDH2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.0 0.0 0.00012 0.21 42 86 .. 28 80 .. 6 169 .. 0.67 Alignments for each domain: == domain 1 score: 14.0 bits; conditional E-value: 0.00012 T...-SEEEEEESS--.....---TT-EEEE--TTSSSHHHHHHHHHHH.....S CS FtsJ 42 rlgakgkvvavDlqpm.....aplpgvttiqgditdpetiekikealse.....r 86 r +++kv+a D+++ ++ pg++t d+t++++i+++ + +++ + sp|Q9BUT1-2|BDH2_HUMAN 28 R--EGAKVIATDINESklqelEKYPGIQTRVLDVTKKKQIDQFANEVERldvlfN 80 2..259********99665444449****************99987766444431 PP >> sp|Q9BVS5|TR61B_HUMAN tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens GN=TRMT61B PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.3 0.0 0.00019 0.33 14 118 .. 240 383 .. 235 417 .. 0.68 Alignments for each domain: == domain 1 score: 13.3 bits; conditional E-value: 0.00019 HHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--......................---.TT-EEEE--TTSSSHHHH CS FtsJ 14 ekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm......................apl.pgvttiqgditdpetiek 78 + ++ ++pg+tv++ g++ Gg s +l++ +g +g+v+++ +++ + ++v +i+ di + k sp|Q9BVS5|TR61B_HUMAN 240 SMMD-INPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDhhdlakknykhwrdswklshveE-WpDNVDFIHKDISGATEDIK 325 5566.78************************99********99888888877777766665544322.13677777777744433332 PP HHHHHHHSSEEEEEE---.-......................---S-.HHHHHHHHHHHHHHHH CS FtsJ 79 ikealserkvdlvvsDga.p......................dvsgv.hdldeylqsqLllaal 118 + +d v D+ p +++ v + ld +++++L+l+ sp|Q9BVS5|TR61B_HUMAN 326 SL------TFDAVALDMLnPhvtlpvfyphlkhggvcavyvvNITQViELLDGIRTCELALSCE 383 33......48999999984455555555555555555555554444435555555566655555 PP >> tr|B7Z972|B7Z972_HUMAN Protein-L-isoaspartate O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.4 0.1 0.00035 0.61 16 65 .. 38 87 .. 30 150 .. 0.66 Alignments for each domain: == domain 1 score: 12.4 bits; conditional E-value: 0.00035 H--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----.TT-EE CS FtsJ 16 fklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmapl.pgvtt 65 f+ +++g +++D+g++ G + + ++ +g +gkv+++D + ++ + v+ tr|B7Z972|B7Z972_HUMAN 38 FDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKE-LVdDSVNN 87 555679**********************99********8663.11233332 PP >> tr|H3BR19|H3BR19_HUMAN Protein CMTR2 (Fragment) OS=Homo sapiens GN=CMTR2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.9 0.0 0.00026 0.45 3 42 .. 112 157 .. 110 158 .] 0.76 Alignments for each domain: == domain 1 score: 12.9 bits; conditional E-value: 0.00026 SHHHHHHHHHHHHH--S-TT......-EEEEES-TT-HHHHHHTTT CS FtsJ 3 sRsayKLleidekfklfkpg......ktvvDlgaaPGgwsqvllqr 42 +++++K ei+ f l+ ++ + ++l+ aPG+++ l++ tr|H3BR19|H3BR19_HUMAN 112 TQAWCKFHEILCSFPLIPQEafqngkLNSLHLCEAPGAFIASLNHY 157 57999999**999997743323333345***********9988875 PP >> sp|P22061|PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=1 SV=4 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.1 0.00051 0.88 16 65 .. 73 122 .. 65 187 .. 0.67 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.00051 H--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----.TT-EE CS FtsJ 16 fklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmapl.pgvtt 65 f+ +++g +++D+g++ G + + ++ +g +gkv+++D + ++ + v+ sp|P22061|PIMT_HUMAN 73 FDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKE-LVdDSVNN 122 555679**********************99********8663.11233332 PP >> sp|P22061-2|PIMT_HUMAN Isoform 2 of Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.0 0.00053 0.91 16 64 .. 73 121 .. 65 184 .. 0.67 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.00053 H--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-----.TT-E CS FtsJ 16 fklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmapl.pgvt 64 f+ +++g +++D+g++ G + + ++ +g +gkv+++D + ++ + v+ sp|P22061-2|PIMT_HUMAN 73 FDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKE-LVdDSVN 121 555679**********************99********8663.1123333 PP >> tr|C9J0F2|C9J0F2_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase (Fragment) OS=Homo sapiens GN=PCMT1 P # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.7 0.0 0.00029 0.51 16 56 .. 42 82 .. 34 95 .. 0.81 Alignments for each domain: == domain 1 score: 12.7 bits; conditional E-value: 0.00029 H--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS- CS FtsJ 16 fklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqp 56 f+ +++g +++D+g++ G + + ++ +g +gkv+++D + tr|C9J0F2|C9J0F2_HUMAN 42 FDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIK 82 555679**********************99********744 PP >> tr|F8WDR2|F8WDR2_HUMAN tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens GN=TRMT61B PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.2 0.0 0.00043 0.74 14 99 .. 240 341 .. 235 358 .. 0.71 Alignments for each domain: == domain 1 score: 12.2 bits; conditional E-value: 0.00043 HHH--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--......................---.TT-EEEE--TTSSSHHH CS FtsJ 14 ekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm......................apl.pgvttiqgditdpetie 77 + ++ ++pg+tv++ g++ Gg s +l++ +g +g+v+++ +++ + ++v +i+ di + tr|F8WDR2|F8WDR2_HUMAN 240 SMMD-INPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDhhdlakknykhwrdswklshveE-WpDNVDFIHKDISGATEDI 324 5566.78************************99********99888887777766666555543322.1357777777774433222 PP HHHHHHHHSSEEEEEE---.--- CS FtsJ 78 kikealserkvdlvvsDga.pdv 99 k + +d v D+ p v tr|F8WDR2|F8WDR2_HUMAN 325 KSL------TFDAVALDMLnPHV 341 222......37777777764555 PP >> sp|Q9BUT1|BDH2_HUMAN 3-hydroxybutyrate dehydrogenase type 2 OS=Homo sapiens GN=BDH2 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.4 0.0 0.00035 0.61 42 86 .. 28 80 .. 6 167 .. 0.73 Alignments for each domain: == domain 1 score: 12.4 bits; conditional E-value: 0.00035 T...-SEEEEEESS--.....---TT-EEEE--TTSSSHHHHHHHHHHH.....S CS FtsJ 42 rlgakgkvvavDlqpm.....aplpgvttiqgditdpetiekikealse.....r 86 r +++kv+a D+++ ++ pg++t d+t++++i+++ + +++ + sp|Q9BUT1|BDH2_HUMAN 28 R--EGAKVIATDINESklqelEKYPGIQTRVLDVTKKKQIDQFANEVERldvlfN 80 2..259********99665444449****************99987766443331 PP >> tr|J3KP72|J3KP72_HUMAN Protein-L-isoaspartate O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.2 0.1 0.00087 1.5 16 57 .. 131 172 .. 123 241 .. 0.68 Alignments for each domain: == domain 1 score: 11.2 bits; conditional E-value: 0.00087 H--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-- CS FtsJ 16 fklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm 57 f+ +++g +++D+g++ G + + ++ +g +gkv+++D + tr|J3KP72|J3KP72_HUMAN 131 FDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKE 172 555679**********************99********8663 PP >> tr|H7BY58|H7BY58_HUMAN Protein-L-isoaspartate O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.1 0.1 0.00088 1.5 16 57 .. 131 172 .. 123 241 .. 0.68 Alignments for each domain: == domain 1 score: 11.1 bits; conditional E-value: 0.00088 H--S-TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS-- CS FtsJ 16 fklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm 57 f+ +++g +++D+g++ G + + ++ +g +gkv+++D + tr|H7BY58|H7BY58_HUMAN 131 FDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKE 172 555679**********************99********8663 PP >> tr|E9PQ06|E9PQ06_HUMAN Short-chain dehydrogenase/reductase family 42E member 1 (Fragment) OS=Homo sapiens GN=SDR42E1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.0 0.00051 0.88 40 104 .. 25 86 .. 17 112 .. 0.75 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.00051 TTT...-SEEEEEES.S-----.TT-EEEE--TTSSSHHHHHHHHHHHSSEEEEEE-------S-HH CS FtsJ 40 lqrlgakgkvvavDl.qpmapl.pgvttiqgditdpetiekikealserkvdlvvsDgapdvsgvhd 104 l++ + +v+ +D+ p + + +g+++iqgdi++ + e +a++++ v +v + + +sg+++ tr|E9PQ06|E9PQ06_HUMAN 25 LNQN--GVHVILFDIsSPAQTIpEGIKFIQGDIRHLSDVE---KAFQDADVTCVFHIASYGMSGREQ 86 3442..368999999666677789************9988...566677777777666666666555 PP >> sp|Q96LA8|ANM6_HUMAN Protein arginine N-methyltransferase 6 OS=Homo sapiens GN=PRMT6 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.6 0.0 0.0013 2.2 21 58 .. 82 119 .. 67 214 .. 0.83 Alignments for each domain: == domain 1 score: 10.6 bits; conditional E-value: 0.0013 TT-EEEEES-TT-HHHHHHTTT...-SEEEEEESS--..- CS FtsJ 21 pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpm..a 58 +gktv+D+ga++G s +++q ga +v+av + + sp|Q96LA8|ANM6_HUMAN 82 RGKTVLDVGAGTGILSIFCAQA-GA-RRVYAVEASAIwqQ 119 789*******************.88.9*****99888652 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (177 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 2052 (0.0231935); expected 1769.5 (0.02) Passed bias filter: 1820 (0.0205712); expected 1769.5 (0.02) Passed Vit filter: 168 (0.00189888); expected 88.5 (0.001) Passed Fwd filter: 51 (0.000576447); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 51 [number of targets reported over threshold] # CPU time: 0.58u 0.03s 00:00:00.61 Elapsed: 00:00:00.23 # Mc/sec: 26989.05 // [ok]