# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/GCD14.hmm.txt
# target sequence database: proteomes/Homo_sapiens.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: GCD14 [M=247]
Accession: PF08704.9
Description: tRNA methyltransferase complex GCD14 subunit
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
2.9e-104 350.4 0.2 1.3e-101 341.7 0.2 2.1 1 sp|Q96FX7|TRM61_HUMAN tRNA (adenine(58)-N(1))-methyltransf
3.6e-74 251.8 0.2 5.4e-69 234.9 0.0 2.0 2 tr|H0Y2Q1|H0Y2Q1_HUMAN tRNA (adenine(58)-N(1))-methyltransf
2.9e-19 72.0 0.0 4e-19 71.5 0.0 1.1 1 sp|Q9BVS5|TR61B_HUMAN tRNA (adenine(58)-N(1))-methyltransf
6.8e-15 57.7 0.0 1e-14 57.1 0.0 1.2 1 tr|F8WDR2|F8WDR2_HUMAN tRNA (adenine(58)-N(1))-methyltransf
0.00035 22.6 0.0 0.0005 22.1 0.0 1.2 1 tr|M0R299|M0R299_HUMAN rRNA 2'-O-methyltransferase fibrilla
0.00042 22.3 0.0 0.00061 21.8 0.0 1.2 1 tr|M0QXL5|M0QXL5_HUMAN rRNA 2'-O-methyltransferase fibrilla
0.0006 21.8 0.0 0.00087 21.3 0.0 1.2 1 tr|M0R2Q4|M0R2Q4_HUMAN rRNA 2'-O-methyltransferase fibrilla
0.0008 21.4 0.0 0.0012 20.9 0.0 1.2 1 sp|P22087|FBRL_HUMAN rRNA 2'-O-methyltransferase fibrilla
0.0012 20.9 0.0 0.0018 20.3 0.0 1.2 1 tr|M0R0P1|M0R0P1_HUMAN rRNA 2'-O-methyltransferase fibrilla
0.0034 19.4 0.0 0.0037 19.3 0.0 1.1 1 tr|C9J0F2|C9J0F2_HUMAN Protein-L-isoaspartate(D-aspartate)
0.0044 19.0 0.0 0.0054 18.7 0.0 1.1 1 tr|B7Z972|B7Z972_HUMAN Protein-L-isoaspartate O-methyltrans
0.0061 18.5 0.0 0.0079 18.2 0.0 1.2 1 sp|P22061|PIMT_HUMAN Protein-L-isoaspartate(D-aspartate)
0.0061 18.5 0.0 0.008 18.2 0.0 1.2 1 sp|P22061-2|PIMT_HUMAN Isoform 2 of Protein-L-isoaspartate(
0.0091 18.0 0.0 0.013 17.5 0.0 1.2 1 tr|J3KP72|J3KP72_HUMAN Protein-L-isoaspartate O-methyltrans
0.0091 18.0 0.0 0.013 17.5 0.0 1.2 1 tr|H7BY58|H7BY58_HUMAN Protein-L-isoaspartate O-methyltrans
------ inclusion threshold ------
0.011 17.7 0.0 0.016 17.2 0.0 1.2 1 sp|A6NHQ2|FBLL1_HUMAN rRNA/tRNA 2'-O-methyltransferase fib
0.011 17.7 0.0 0.016 17.1 0.0 1.2 1 tr|R4GMW7|R4GMW7_HUMAN rRNA/tRNA 2'-O-methyltransferase fib
0.018 17.0 0.1 0.076 14.9 0.0 1.8 2 sp|Q96MG8|PCMD1_HUMAN Protein-L-isoaspartate O-methyltrans
0.051 15.5 0.0 0.076 14.9 0.0 1.4 1 tr|F8W9F3|F8W9F3_HUMAN Protein-L-isoaspartate O-methyltrans
0.059 15.3 0.0 0.1 14.5 0.0 1.5 1 sp|Q9NV79-2|PCMD2_HUMAN Isoform 2 of Protein-L-isoaspartate
0.068 15.1 0.0 0.13 14.2 0.0 1.5 1 sp|Q9NV79|PCMD2_HUMAN Protein-L-isoaspartate O-methyltrans
0.089 14.7 0.1 0.11 14.4 0.1 1.1 1 tr|C9JDL5|C9JDL5_HUMAN Bromodomain testis-specific protein
0.13 14.2 0.2 0.15 14.0 0.2 1.1 1 tr|C9JD82|C9JD82_HUMAN Bromodomain testis-specific protein
0.71 11.8 0.0 0.79 11.6 0.0 1.1 1 tr|C9J1F7|C9J1F7_HUMAN Bromodomain testis-specific protein
1.3 10.9 0.0 1.7 10.5 0.0 1.1 1 sp|Q8WZ04-2|TOMT_HUMAN Isoform 2 of Transmembrane O-methylt
1.4 10.8 0.1 1.9 10.4 0.1 1.1 1 tr|M0R1H0|M0R1H0_HUMAN rRNA 2'-O-methyltransferase fibrilla
2.4 10.0 3.6 0.86 11.5 0.3 1.9 2 tr|C9JJU3|C9JJU3_HUMAN Bromodomain testis-specific protein
Domain annotation for each sequence (and alignments):
>> sp|Q96FX7|TRM61_HUMAN tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens GN=TRMT61A
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 341.7 0.2 4.1e-105 1.3e-101 1 247 [] 64 286 .. 64 286 .. 0.97
Alignments for each domain:
== domain 1 score: 341.7 bits; conditional E-value: 4.1e-105
GCD14 1 gfvyvlaptPeLWtlaLphrtqilytaDisliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefreh 88
g+vyvl+ptPeLWtl+Lphrtqily++Di+li+m+Lel+pGsvv+esGtGsgs+shai+rt+aPtGhl+t+efh+qraekareef+eh
sp|Q96FX7|TRM61_HUMAN 64 GWVYVLHPTPELWTLNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQEH 151
8*************************************************************************************** PP
GCD14 89 elsqlvtvthrDvckeGfdeevsgkvDavfLDlPaPweaiphaakalkkeggrlCsfsPCieqvqrtceaLrelgfteietlevllrt 176
++ +vtv+++Dvc++Gf +vs+++DavfLD+P+Pwea++ha++alk eggr+CsfsPCieqvqrtc+aL++ gf e++tlevl ++
sp|Q96FX7|TRM61_HUMAN 152 RVGRWVTVRTQDVCRSGF--GVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGFSELSTLEVLPQV 237
******************..9******************************************************************* PP
GCD14 177 yevrkskleeidlaekrleenerkriekakrrkaskdakvedkssksstevllkPvselkghtgyLtfatk 247
y+vr+++l+ dl++ + ++++ ++s++ P++e++ghtgyLtfatk
sp|Q96FX7|TRM61_HUMAN 238 YNVRTVSLPPPDLGTGTDGPA--------------GSDTSPFRSGT--------PMKEAVGHTGYLTFATK 286
*************97654433..............55678999999........***************86 PP
>> tr|H0Y2Q1|H0Y2Q1_HUMAN tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (Fragment) OS=Homo sapien
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 234.9 0.0 1.6e-72 5.4e-69 40 191 .. 6 154 .. 3 165 .. 0.96
2 ! 15.4 0.1 1.7e-05 0.054 229 247 .] 170 188 .. 160 188 .. 0.85
Alignments for each domain:
== domain 1 score: 234.9 bits; conditional E-value: 1.6e-72
GCD14 40 pGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvckeGfdeevsgkvDavfLDlPaPwe 126
pGs+ v +GtGsgs+shai+rt+aPtGhl+t+efh+qraekareef+eh++ +vtv+++Dvc++Gf +vs+++DavfLD+P+Pwe
tr|H0Y2Q1|H0Y2Q1_HUMAN 6 PGSRSV-AGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQEHRVGRWVTVRTQDVCRSGF--GVSHVADAVFLDIPSPWE 89
688877.8***********************************************************..9***************** PP
GCD14 127 aiphaakalkkeggrlCsfsPCieqvqrtceaLrelgfteietlevllrtyevrkskleeidlae 191
a++ha++alk eggr+CsfsPCieqvqrtc+aL++ gf e++tlevl ++y+vr+++l+ dl++
tr|H0Y2Q1|H0Y2Q1_HUMAN 90 AVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGFSELSTLEVLPQVYNVRTVSLPPPDLGT 154
**********************************************************9999865 PP
== domain 2 score: 15.4 bits; conditional E-value: 1.7e-05
GCD14 229 lkPvselkghtgyLtfatk 247
P++e++ghtgyLtfatk
tr|H0Y2Q1|H0Y2Q1_HUMAN 170 GTPMKEAVGHTGYLTFATK 188
57***************86 PP
>> sp|Q9BVS5|TR61B_HUMAN tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens GN=TRMT61B PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 71.5 0.0 1.2e-22 4e-19 11 243 .. 217 467 .. 208 471 .. 0.76
Alignments for each domain:
== domain 1 score: 71.5 bits; conditional E-value: 1.2e-22
GCD14 11 eLWtlaLphrtqilytaDisliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel........ 90
e + + ++ t i + +Di +i +++++pG v+e+G Gsg +s ++++v+ +G++ +fe ++ + a++++++ +
sp|Q9BVS5|TR61B_HUMAN 217 EDYVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDswklshve 304
55666677779****************************************************9999999999988654323335555 PP
GCD14 91 ..sqlvtvthrDvckeGfdeevsg.kvDavfLDlPaPweaiphaakalkkeggrlCsfsPCieqvqrtceaLrelgft.ei.etlevl 173
++v h+D+ G +e++++ + Dav LD+ +P +p +l k+gg+ + i qv + + +r + + ev
sp|Q9BVS5|TR61B_HUMAN 305 ewPDNVDFIHKDIS--GATEDIKSlTFDAVALDMLNPHVTLPVFYPHL-KHGGVCAVYVVNITQVIELLDGIRTCELAlSCeKISEVI 389
54568999999996..55667765268*********************.6778877899999999998888887654323315669** PP
GCD14 174 lrtyevrkskleeidlaekrleenerkri.ekakrrka....skdakvedkssks...stevllkPvselkghtgyLt 243
+r + v k ++ la+k + + +++ + ++++ + +++ e+ +s++ s +++Pv+ ght++L+
sp|Q9BVS5|TR61B_HUMAN 390 VRDWLVCLAKQKNGILAQKVESKINTDVQlDSQEKIGVkgelFQEDDHEESHSDFpygSFPYVARPVHWQPGHTAFLV 467
*****999988888777777666655533034444444334434444444444448888899**************96 PP
>> tr|F8WDR2|F8WDR2_HUMAN tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens GN=TRMT61B PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 57.1 0.0 3e-18 1e-14 11 142 .. 217 355 .. 208 360 .. 0.81
Alignments for each domain:
== domain 1 score: 57.1 bits; conditional E-value: 3e-18
GCD14 11 eLWtlaLphrtqilytaDisliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel....... 90
e + + ++ t i + +Di +i +++++pG v+e+G Gsg +s ++++v+ +G++ +fe ++ + a++++++ +
tr|F8WDR2|F8WDR2_HUMAN 217 EDYVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDswklshv 303
55666677779****************************************************999999999998865432333555 PP
GCD14 91 ...sqlvtvthrDvckeGfdeevsg.kvDavfLDlPaPweaiphaakalkkeggrl 142
++v h+D+ G +e++++ + Dav LD+ +P +p +lk+ +
tr|F8WDR2|F8WDR2_HUMAN 304 eewPDNVDFIHKDIS--GATEDIKSlTFDAVALDMLNPHVTLPVFYPHLKHG--GV 355
554568999999996..55667765268***************999999543..34 PP
>> tr|M0R299|M0R299_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 22.1 0.0 1.5e-07 0.0005 35 150 .. 69 185 .. 61 212 .. 0.69
Alignments for each domain:
== domain 1 score: 22.1 bits; conditional E-value: 1.5e-07
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvckeGfdeevsgkvDavfLDl 121
++++kpG++v+ G+ sg+ + ++ v+P G ++++ef + r + + ++ +++ ++++ v + + ++ + vD +f D+
tr|M0R299|M0R299_HUMAN 69 QIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSH-RSGRDLINLAKKR-TNIIPVIEDARHPHKYR-MLIAMVDVIFADV 152
789************************************65.4444455555444.34455544334456664.55599******** PP
GCD14 122 PaPwea.ip..haakalkkeggrlCsf.sPCie 150
+P++ i +a + l++ g + s + Ci+
tr|M0R299|M0R299_HUMAN 153 AQPDQTrIValNAHTFLRNGGHFVISIkANCID 185
***986332013333344444433443245665 PP
>> tr|M0QXL5|M0QXL5_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 21.8 0.0 1.9e-07 0.00061 35 150 .. 92 208 .. 84 233 .. 0.69
Alignments for each domain:
== domain 1 score: 21.8 bits; conditional E-value: 1.9e-07
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvckeGfdeevsgkvDavfLDl 121
++++kpG++v+ G+ sg+ + ++ v+P G ++++ef + r + + ++ +++ ++++ v + + ++ + vD +f D+
tr|M0QXL5|M0QXL5_HUMAN 92 QIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSH-RSGRDLINLAKKR-TNIIPVIEDARHPHKYR-MLIAMVDVIFADV 175
789************************************65.4444455555444.34455544334456664.55599******** PP
GCD14 122 PaPwea.ip..haakalkkeggrlCsf.sPCie 150
+P++ i +a + l++ g + s + Ci+
tr|M0QXL5|M0QXL5_HUMAN 176 AQPDQTrIValNAHTFLRNGGHFVISIkANCID 208
***986332013333344444333443245665 PP
>> tr|M0R2Q4|M0R2Q4_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 21.3 0.0 2.6e-07 0.00087 35 150 .. 130 246 .. 122 267 .. 0.69
Alignments for each domain:
== domain 1 score: 21.3 bits; conditional E-value: 2.6e-07
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvckeGfdeevsgkvDavfLDl 121
++++kpG++v+ G+ sg+ + ++ v+P G ++++ef + r + + ++ +++ ++++ v + + ++ + vD +f D+
tr|M0R2Q4|M0R2Q4_HUMAN 130 QIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSH-RSGRDLINLAKKR-TNIIPVIEDARHPHKYR-MLIAMVDVIFADV 213
789************************************65.4444455555444.34455544334456664.55599******** PP
GCD14 122 PaPwea.ip..haakalkkeggrlCsf.sPCie 150
+P++ i +a + l++ g + s + Ci+
tr|M0R2Q4|M0R2Q4_HUMAN 214 AQPDQTrIValNAHTFLRNGGHFVISIkANCID 246
***986332012333344433333343245665 PP
>> sp|P22087|FBRL_HUMAN rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens GN=FBL PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 20.9 0.0 3.5e-07 0.0012 35 150 .. 154 270 .. 146 296 .. 0.69
Alignments for each domain:
== domain 1 score: 20.9 bits; conditional E-value: 3.5e-07
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvckeGfdeevsgkvDavfLDlPa 123
++++kpG++v+ G+ sg+ + ++ v+P G ++++ef + r + + ++ +++ ++++ v + + ++ + vD +f D+ +
sp|P22087|FBRL_HUMAN 154 QIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSH-RSGRDLINLAKKR-TNIIPVIEDARHPHKYR-MLIAMVDVIFADVAQ 239
789************************************65.4444455555444.34455544334456664.55599********** PP
GCD14 124 Pwea.ip..haakalkkeggrlCsf.sPCie 150
P++ i +a + l++ g + s + Ci+
sp|P22087|FBRL_HUMAN 240 PDQTrIValNAHTFLRNGGHFVISIkANCID 270
*986332013333344444333443245665 PP
>> tr|M0R0P1|M0R0P1_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 20.3 0.0 5.4e-07 0.0018 35 127 .. 117 206 .. 109 225 .. 0.75
Alignments for each domain:
== domain 1 score: 20.3 bits; conditional E-value: 5.4e-07
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvckeGfdeevsgkvDavfLDl 121
++++kpG++v+ G+ sg+ + ++ v+P G ++++ef + r + + ++ +++ ++++ v + + ++ + vD +f D+
tr|M0R0P1|M0R0P1_HUMAN 117 QIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSH-RSGRDLINLAKKR-TNIIPVIEDARHPHKYR-MLIAMVDVIFADV 200
789************************************65.4444444555444.34455544333456664.455999******* PP
GCD14 122 PaPwea 127
+P++
tr|M0R0P1|M0R0P1_HUMAN 201 AQPDQT 206
999975 PP
>> tr|C9J0F2|C9J0F2_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase (Fragment) OS=Homo sapiens GN=PCMT1 P
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 19.3 0.0 1.1e-06 0.0037 37 87 .. 44 94 .. 27 96 .] 0.90
Alignments for each domain:
== domain 1 score: 19.3 bits; conditional E-value: 1.1e-06
GCD14 37 elkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefre 87
+l++G+++++ G Gsg l+ +ar v+ tG++ +++ ++ ++ ++++ r+
tr|C9J0F2|C9J0F2_HUMAN 44 QLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRK 94
5789********************************999999998888876 PP
>> tr|B7Z972|B7Z972_HUMAN Protein-L-isoaspartate O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.7 0.0 1.6e-06 0.0054 37 90 .. 40 93 .. 29 146 .. 0.80
Alignments for each domain:
== domain 1 score: 18.7 bits; conditional E-value: 1.6e-06
GCD14 37 elkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel 90
+l++G+++++ G Gsg l+ +ar v+ tG++ +++ ++ ++ ++++ r+++
tr|B7Z972|B7Z972_HUMAN 40 QLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDP 93
5789************************************99999999998764 PP
>> sp|P22061|PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=1 SV=4
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.2 0.0 2.4e-06 0.0079 37 90 .. 75 128 .. 63 180 .. 0.81
Alignments for each domain:
== domain 1 score: 18.2 bits; conditional E-value: 2.4e-06
GCD14 37 elkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel 90
+l++G+++++ G Gsg l+ +ar v+ tG++ +++ ++ ++ ++++ r+++
sp|P22061|PIMT_HUMAN 75 QLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDP 128
5789************************************99999999998764 PP
>> sp|P22061-2|PIMT_HUMAN Isoform 2 of Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.2 0.0 2.4e-06 0.008 37 90 .. 75 128 .. 63 180 .. 0.81
Alignments for each domain:
== domain 1 score: 18.2 bits; conditional E-value: 2.4e-06
GCD14 37 elkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel 90
+l++G+++++ G Gsg l+ +ar v+ tG++ +++ ++ ++ ++++ r+++
sp|P22061-2|PIMT_HUMAN 75 QLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDP 128
5789************************************99999999998764 PP
>> tr|J3KP72|J3KP72_HUMAN Protein-L-isoaspartate O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.5 0.0 3.9e-06 0.013 37 90 .. 133 186 .. 122 238 .. 0.81
Alignments for each domain:
== domain 1 score: 17.5 bits; conditional E-value: 3.9e-06
GCD14 37 elkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel 90
+l++G+++++ G Gsg l+ +ar v+ tG++ +++ ++ ++ ++++ r+++
tr|J3KP72|J3KP72_HUMAN 133 QLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDP 186
5789************************************99999999998764 PP
>> tr|H7BY58|H7BY58_HUMAN Protein-L-isoaspartate O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.5 0.0 3.9e-06 0.013 37 90 .. 133 186 .. 122 238 .. 0.81
Alignments for each domain:
== domain 1 score: 17.5 bits; conditional E-value: 3.9e-06
GCD14 37 elkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel 90
+l++G+++++ G Gsg l+ +ar v+ tG++ +++ ++ ++ ++++ r+++
tr|H7BY58|H7BY58_HUMAN 133 QLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDP 186
5789************************************99999999998764 PP
>> sp|A6NHQ2|FBLL1_HUMAN rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 OS=Homo sapiens GN=FBLL1 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 17.2 0.0 4.9e-06 0.016 35 150 .. 166 282 .. 156 307 .. 0.71
Alignments for each domain:
== domain 1 score: 17.2 bits; conditional E-value: 4.9e-06
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvc.keGfdeevsgkvDavfLDl 121
++++kp s+v+ G+ sg+ + ++ ++P G ++++ef +ra + + + +++ +++ v D+ + + + g vD +f D+
sp|A6NHQ2|FBLL1_HUMAN 166 QIHIKPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFS-HRAGRDLVNVAKKRT-NIIPVL-EDARhPLKY-RMLIGMVDVIFADV 249
7899****************99*****************6.466666666665553.344444.444414445.5566********** PP
GCD14 122 PaPwea.ip..haakalkkeggrlCsf.sPCie 150
+P+++ i +a + l++ g l s + Ci+
sp|A6NHQ2|FBLL1_HUMAN 250 AQPDQSrIValNAHTFLRNGGHFLISIkANCID 282
***986332113334455555555554245665 PP
>> tr|R4GMW7|R4GMW7_HUMAN rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 OS=Homo sapiens GN=FBLL1 PE=3 SV=
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 17.1 0.0 4.9e-06 0.016 35 150 .. 166 282 .. 156 307 .. 0.71
Alignments for each domain:
== domain 1 score: 17.1 bits; conditional E-value: 4.9e-06
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvc.keGfdeevsgkvDavfLD 120
++++kp s+v+ G+ sg+ + ++ ++P G ++++ef +ra + + + +++ +++ v D+ + + + g vD +f D
tr|R4GMW7|R4GMW7_HUMAN 166 QIHIKPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFS-HRAGRDLVNVAKKRT-NIIPVL-EDARhPLKY-RMLIGMVDVIFAD 248
7899****************99*****************6.466666666665553.344444.444414445.5566********* PP
GCD14 121 lPaPwea.ip..haakalkkeggrlCsf.sPCie 150
+ +P+++ i +a + l++ g l s + Ci+
tr|R4GMW7|R4GMW7_HUMAN 249 VAQPDQSrIValNAHTFLRNGGHFLISIkANCID 282
****986332113334455555555554245665 PP
>> sp|Q96MG8|PCMD1_HUMAN Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Homo sapiens GN=PCMT
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 14.9 0.0 2.3e-05 0.076 30 86 .. 70 126 .. 60 141 .. 0.92
2 ? -0.8 0.0 1.5 4.8e+03 195 218 .. 304 327 .. 281 355 .. 0.49
Alignments for each domain:
== domain 1 score: 14.9 bits; conditional E-value: 2.3e-05
GCD14 30 sliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefr 86
s ++ L+l+pG ++ G G+g ls+ + ++P G + +e h + +e a+e+++
sp|Q96MG8|PCMD1_HUMAN 70 SEVMEALKLQPGLSFLNLGSGTGYLSTMVGLILGPFGINHGIELHSDVVEYAKEKLE 126
568899******************************************999998765 PP
== domain 2 score: -0.8 bits; conditional E-value: 1.5
GCD14 195 eenerkriekakrrkaskdakved 218
e+++ ++ +k +++k +++a + +
sp|Q96MG8|PCMD1_HUMAN 304 EDEKMEEDNKEEEEKDHNEAMKPE 327
222222222222333333322222 PP
>> tr|F8W9F3|F8W9F3_HUMAN Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Homo sapiens GN=PCM
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 14.9 0.0 2.3e-05 0.076 30 84 .. 70 124 .. 36 147 .. 0.92
Alignments for each domain:
== domain 1 score: 14.9 bits; conditional E-value: 2.3e-05
GCD14 30 sliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekaree 84
s ++ L+l+pG ++ G G+g ls+ + ++P G + +e h + +e a+++
tr|F8W9F3|F8W9F3_HUMAN 70 SEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNHGVELHSDVIEYAKQK 124
568899*****************************************99999885 PP
>> sp|Q9NV79-2|PCMD2_HUMAN Isoform 2 of Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Homo
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 14.5 0.0 3.1e-05 0.1 30 84 .. 70 124 .. 37 147 .. 0.92
Alignments for each domain:
== domain 1 score: 14.5 bits; conditional E-value: 3.1e-05
GCD14 30 sliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekaree 84
s ++ L+l+pG ++ G G+g ls+ + ++P G + +e h + +e a+++
sp|Q9NV79-2|PCMD2_HUMAN 70 SEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNHGVELHSDVIEYAKQK 124
568899*****************************************99999885 PP
>> sp|Q9NV79|PCMD2_HUMAN Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Homo sapiens GN=PCMT
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 14.2 0.0 3.9e-05 0.13 30 84 .. 70 124 .. 54 147 .. 0.91
Alignments for each domain:
== domain 1 score: 14.2 bits; conditional E-value: 3.9e-05
GCD14 30 sliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekaree 84
s ++ L+l+pG ++ G G+g ls+ + ++P G + +e h + +e a+++
sp|Q9NV79|PCMD2_HUMAN 70 SEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNHGVELHSDVIEYAKQK 124
568899*****************************************99999885 PP
>> tr|C9JDL5|C9JDL5_HUMAN Bromodomain testis-specific protein (Fragment) OS=Homo sapiens GN=BRDT PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 14.4 0.1 3.3e-05 0.11 88 218 .. 30 167 .. 20 194 .. 0.69
Alignments for each domain:
== domain 1 score: 14.4 bits; conditional E-value: 3.3e-05
GCD14 88 helsqlvtvthrDvckeGfdeevsgkvDavfLDlPaPweaiphaa..kal..kkeggrlCsfsPCieqvqrtcea..Lrelgfteie 168
++l+ l +v +D+ k+ f+ + vDav L lP + i++ + +++ + e+ s Cie + L ++ +i
tr|C9JDL5|C9JDL5_HUMAN 30 NQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMdlNTIkkRLENKYYAKASECIEDFNTMFSNcyLYNKPGDDIV 116
45666788999******************************987611456333467888999*****98875443225566666665 PP
GCD14 169 .tlevllrtyevrkskleeidlaekrleenerkriekakrrkaskdakved 218
+ + l + + + s++++ + +e ++ + +++ ++a+++++ +
tr|C9JDL5|C9JDL5_HUMAN 117 lMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSA 167
256789999999999999988865555554444444433333333322222 PP
>> tr|C9JD82|C9JD82_HUMAN Bromodomain testis-specific protein (Fragment) OS=Homo sapiens GN=BRDT PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 14.0 0.2 4.5e-05 0.15 88 214 .. 30 163 .. 20 176 .] 0.69
Alignments for each domain:
== domain 1 score: 14.0 bits; conditional E-value: 4.5e-05
GCD14 88 helsqlvtvthrDvckeGfdeevsgkvDavfLDlPaPweaiphaa..kal..kkeggrlCsfsPCieqvqrtcea..Lrelgfteie 168
++l+ l +v +D+ k+ f+ + vDav L lP + i++ + +++ + e+ s Cie + L ++ +i
tr|C9JD82|C9JD82_HUMAN 30 NQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMdlNTIkkRLENKYYAKASECIEDFNTMFSNcyLYNKPGDDIV 116
45666788999******************************987611456333467888999*****98875443225555666665 PP
GCD14 169 .tlevllrtyevrkskleeidlaekrleenerkriekakrrkaskda 214
+ + l + + + s++++ + +e ++ + +++ ++a++++
tr|C9JD82|C9JD82_HUMAN 117 lMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKS 163
15678889999999999988876655555544444444333333322 PP
>> tr|C9J1F7|C9J1F7_HUMAN Bromodomain testis-specific protein (Fragment) OS=Homo sapiens GN=BRDT PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.6 0.0 0.00024 0.79 88 156 .. 30 102 .. 20 154 .. 0.69
Alignments for each domain:
== domain 1 score: 11.6 bits; conditional E-value: 0.00024
GCD14 88 helsqlvtvthrDvckeGfdeevsgkvDavfLDlPaPweaiphaa..kal..kkeggrlCsfsPCieqvqrtc 156
++l+ l +v +D+ k+ f+ + vDav L lP + i++ + +++ + e+ s Cie
tr|C9J1F7|C9J1F7_HUMAN 30 NQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMdlNTIkkRLENKYYAKASECIEDFNTMF 102
45666788999******************************98761145533346777888999999876543 PP
>> sp|Q8WZ04-2|TOMT_HUMAN Isoform 2 of Transmembrane O-methyltransferase OS=Homo sapiens GN=LRTOMT
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.5 0.0 0.00053 1.7 37 90 .. 88 141 .. 79 174 .. 0.80
Alignments for each domain:
== domain 1 score: 10.5 bits; conditional E-value: 0.00053
GCD14 37 elkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel 90
e k + v+e Gt g + iar++ P G+l t+e + a a + r ++
sp|Q8WZ04-2|TOMT_HUMAN 88 EEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGF 141
55667899*********99*****************888888777766665554 PP
>> tr|M0R1H0|M0R1H0_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.4 0.1 0.00057 1.9 35 72 .. 141 178 .] 133 178 .] 0.93
Alignments for each domain:
== domain 1 score: 10.4 bits; conditional E-value: 0.00057
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfe 72
++++kpG++v+ G+ sg+ + ++ v+P G ++++e
tr|M0R1H0|M0R1H0_HUMAN 141 QIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVE 178
789*****************9**************987 PP
>> tr|C9JJU3|C9JJU3_HUMAN Bromodomain testis-specific protein (Fragment) OS=Homo sapiens GN=BRDT PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.5 0.3 0.00026 0.86 89 217 .. 31 166 .. 21 220 .. 0.71
2 ? -1.7 0.3 2.8 9.1e+03 196 226 .. 391 421 .. 352 457 .. 0.56
Alignments for each domain:
== domain 1 score: 11.5 bits; conditional E-value: 0.00026
GCD14 89 elsqlvtvthrDvckeGfdeevsgkvDavfLDlPaPweaiphaa..kal..kkeggrlCsfsPCieqvqrtcea..Lrelgfteie. 168
+l+ l +v +D+ k+ f+ + vDav L lP + i++ + +++ + e+ s Cie + L ++ +i
tr|C9JJU3|C9JJU3_HUMAN 31 QLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMdlNTIkkRLENKYYAKASECIEDFNTMFSNcyLYNKPGDDIVl 117
5666778999******************************987611456333467888999*****988754432255666666651 PP
GCD14 169 tlevllrtyevrkskleeidlaekrleenerkriekakrrkaskdakve 217
+ + l + + + s++++ + +e ++ + +++ ++a+++++ +
tr|C9JJU3|C9JJU3_HUMAN 118 MAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPS 166
5678899999999999988876555554444433333333333222222 PP
== domain 2 score: -1.7 bits; conditional E-value: 2.8
GCD14 196 enerkriekakrrkaskdakvedkssksste 226
++ ++++ + + ++as++ +++d s++ + +
tr|C9JJU3|C9JJU3_HUMAN 391 TDITETTGRENTNEASSEGNSSDDSEDERVK 421
3333323333333333333333333333333 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (247 nodes)
Target sequences: 88473 (35070517 residues searched)
Passed MSV filter: 4407 (0.0498118); expected 1769.5 (0.02)
Passed bias filter: 2988 (0.033773); expected 1769.5 (0.02)
Passed Vit filter: 326 (0.00368474); expected 88.5 (0.001)
Passed Fwd filter: 51 (0.000576447); expected 0.9 (1e-05)
Initial search space (Z): 88473 [actual number of targets]
Domain search space (domZ): 27 [number of targets reported over threshold]
# CPU time: 1.15u 0.03s 00:00:01.18 Elapsed: 00:00:00.36
# Mc/sec: 24062.27
//
[ok]