# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/GCD14.hmm.txt
# target sequence database: proteomes/Pan_troglodytes.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: GCD14 [M=247]
Accession: PF08704.9
Description: tRNA methyltransferase complex GCD14 subunit
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
7.6e-105 350.4 0.2 3.5e-102 341.7 0.2 2.1 1 tr|K7AEF2|K7AEF2_PANTR tRNA (adenine(58)-N(1))-methyltr
7.9e-20 71.9 0.0 1.1e-19 71.5 0.0 1.1 1 tr|H2QHP4|H2QHP4_PANTR tRNA methyltransferase 61B OS=Pa
0.00023 21.3 0.0 0.00034 20.7 0.0 1.2 1 tr|A0A2I3RF95|A0A2I3RF95_PANTR Fibrillarin OS=Pan troglodytes O
0.00027 21.0 0.1 0.00038 20.6 0.1 1.2 1 tr|A0A2I3RSU9|A0A2I3RSU9_PANTR Uncharacterized protein OS=Pan t
0.0018 18.4 0.0 0.0025 17.9 0.0 1.2 1 tr|K7B228|K7B228_PANTR Protein-L-isoaspartate O-methylt
0.0028 17.7 0.0 0.0041 17.2 0.0 1.2 1 tr|A0A2I3RWY8|A0A2I3RWY8_PANTR Fibrillarin like 1 OS=Pan troglo
0.0047 17.0 0.1 0.02 14.9 0.0 1.8 2 tr|H2QW55|H2QW55_PANTR PCMTD1 isoform 2 OS=Pan troglody
------ inclusion threshold ------
0.018 15.1 0.0 0.033 14.2 0.0 1.5 1 tr|A0A2I3SHL6|A0A2I3SHL6_PANTR PCMTD2 isoform 5 OS=Pan troglody
6.9 6.6 6.6 9.5 6.2 4.9 1.8 2 tr|A0A2I3TIN0|A0A2I3TIN0_PANTR Biogenesis of lysosome-related o
Domain annotation for each sequence (and alignments):
>> tr|K7AEF2|K7AEF2_PANTR tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Pan troglodytes OX=959
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 341.7 0.2 1.4e-105 3.5e-102 1 247 [] 64 286 .. 64 286 .. 0.97
Alignments for each domain:
== domain 1 score: 341.7 bits; conditional E-value: 1.4e-105
GCD14 1 gfvyvlaptPeLWtlaLphrtqilytaDisliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefre 87
g+vyvl+ptPeLWtl+Lphrtqily++Di+li+m+Lel+pGsvv+esGtGsgs+shai+rt+aPtGhl+t+efh+qraekareef+e
tr|K7AEF2|K7AEF2_PANTR 64 GWVYVLHPTPELWTLNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQE 150
8************************************************************************************** PP
GCD14 88 helsqlvtvthrDvckeGfdeevsgkvDavfLDlPaPweaiphaakalkkeggrlCsfsPCieqvqrtceaLrelgfteietlevll 174
h++ +vtv+++Dvc++Gf +vs+++DavfLD+P+Pwea++ha++alk eggr+CsfsPCieqvqrtc+aL++ gf e++tlevl
tr|K7AEF2|K7AEF2_PANTR 151 HRVGRWVTVRTQDVCRSGF--GVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGFSELSTLEVLP 235
*******************..9***************************************************************** PP
GCD14 175 rtyevrkskleeidlaekrleenerkriekakrrkaskdakvedkssksstevllkPvselkghtgyLtfatk 247
++y+vr+++l+ dl++ + ++++ ++s++ P++e++ghtgyLtfatk
tr|K7AEF2|K7AEF2_PANTR 236 QVYNVRTVSLPPPDLGTGTDGPA--------------GSDTSPFRSGT--------PMKEAVGHTGYLTFATK 286
***************97654433..............55678999999........***************86 PP
>> tr|H2QHP4|H2QHP4_PANTR tRNA methyltransferase 61B OS=Pan troglodytes OX=9598 GN=TRMT61B PE=4 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 71.5 0.0 4.2e-23 1.1e-19 11 243 .. 216 466 .. 207 470 .. 0.77
Alignments for each domain:
== domain 1 score: 71.5 bits; conditional E-value: 4.2e-23
GCD14 11 eLWtlaLphrtqilytaDisliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel....... 90
e + + ++ t i + +Di +i +++++pG v+e+G Gsg +s ++++v+ +G++ +fe ++ + a++++++ +
tr|H2QHP4|H2QHP4_PANTR 216 EDYVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDswklshv 302
55666677779****************************************************999999999998865432333555 PP
GCD14 91 ...sqlvtvthrDvckeGfdeevsg.kvDavfLDlPaPweaiphaakalkkeggrlCsfsPCieqvqrtceaLrelgft.ei.etle 171
++v h+D+ G +e++++ + Dav LD+ +P +p +l k+gg+ + i qv + + +r + + e
tr|H2QHP4|H2QHP4_PANTR 303 eewPDNVDFIHKDIS--GATEDIKSfTFDAVALDMLNPHVTLPVFYPHL-KHGGVCAVYVVNITQVIELLDGIRTCELAlSCeKISE 386
554568999999996..56667765378*********************.6778877899999999998888887654323315669 PP
GCD14 172 vllrtyevrkskleeidlaekrleenerk.riekakrrka....skdakvedkssks...stevllkPvselkghtgyLt 243
v +r + v k ++ la+k + + +++ r + ++++ + +++ e+ +s++ s +++Pv+ ght++L+
tr|H2QHP4|H2QHP4_PANTR 387 VIVRDWLVCLAKQKNGILAQKVESKINTDvRLDSQEKIGVkgelFQEDDHEESHSDFpygSFPYVARPVHWQPGHTAFLV 466
*******999998888887776665544415566666655333333444444444448888899**************96 PP
>> tr|A0A2I3RF95|A0A2I3RF95_PANTR Fibrillarin OS=Pan troglodytes OX=9598 GN=FBL PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 20.7 0.0 1.3e-07 0.00034 35 150 .. 169 285 .. 161 310 .. 0.69
Alignments for each domain:
== domain 1 score: 20.7 bits; conditional E-value: 1.3e-07
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvckeGfdeevsgk 113
++++kpG++v+ G+ sg+ + ++ v+P G ++++ef + r + + ++ +++ ++++ v + + ++ +
tr|A0A2I3RF95|A0A2I3RF95_PANTR 169 QIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSH-RSGRDLINLAKKR-TNIIPVIEDARHPHKYR-MLIAM 244
789************************************65.4444455555444.34455544334456664.55599 PP
GCD14 114 vDavfLDlPaPwea.ip..haakalkkeggrlCsf.sPCie 150
vD +f D+ +P++ i +a + l++ g + s + Ci+
tr|A0A2I3RF95|A0A2I3RF95_PANTR 245 VDVIFADVAQPDQTrIValNAHTFLRNGGHFVISIkANCID 285
***********986332013333344443333343245665 PP
>> tr|A0A2I3RSU9|A0A2I3RSU9_PANTR Uncharacterized protein OS=Pan troglodytes OX=9598 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 20.6 0.1 1.5e-07 0.00038 35 127 .. 154 243 .. 146 284 .. 0.77
Alignments for each domain:
== domain 1 score: 20.6 bits; conditional E-value: 1.5e-07
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvc.keGfdeevsg 112
++++kpG++v+ G+ sg+ + ++ v+P G ++++ef + r + + ++ +++ +++ v D++ + + + +
tr|A0A2I3RSU9|A0A2I3RSU9_PANTR 154 QIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSH-RSGRDLINLAKKRT-NIIPV-IEDAQhPHKY-RMLIA 228
789************************************65.44444555554443.34444.4566625566.55669 PP
GCD14 113 kvDavfLDlPaPwea 127
vD +f D+ +P++
tr|A0A2I3RSU9|A0A2I3RSU9_PANTR 229 MVDVIFADVAQPDQT 243
9***********986 PP
>> tr|K7B228|K7B228_PANTR Protein-L-isoaspartate O-methyltransferase OS=Pan troglodytes OX=9598 GN=PCMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.9 0.0 9.9e-07 0.0025 37 90 .. 133 186 .. 122 238 .. 0.81
Alignments for each domain:
== domain 1 score: 17.9 bits; conditional E-value: 9.9e-07
GCD14 37 elkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehel 90
+l++G+++++ G Gsg l+ +ar v+ tG++ +++ ++ ++ ++++ r+++
tr|K7B228|K7B228_PANTR 133 QLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSINNVRKDDP 186
5789***************************************99999998764 PP
>> tr|A0A2I3RWY8|A0A2I3RWY8_PANTR Fibrillarin like 1 OS=Pan troglodytes OX=9598 GN=FBLL1 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.2 0.0 1.6e-06 0.0041 35 150 .. 162 278 .. 152 303 .. 0.71
Alignments for each domain:
== domain 1 score: 17.2 bits; conditional E-value: 1.6e-06
GCD14 35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvc.keGfdeevsg 112
++++kp s+v+ G+ sg+ + ++ ++P G ++++ef +ra + + + +++ +++ v D+ + + + g
tr|A0A2I3RWY8|A0A2I3RWY8_PANTR 162 QIHIKPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFS-HRAGRDLVNVAKKRT-NIIPVL-EDARhPLKY-RMLIG 236
7899****************99*****************6.466666666665553.344444.444414445.5566* PP
GCD14 113 kvDavfLDlPaPwea.ip..haakalkkeggrlCsf.sPCie 150
vD +f D+ +P+++ i +a + l++ g l s + Ci+
tr|A0A2I3RWY8|A0A2I3RWY8_PANTR 237 MVDVIFADVAQPDQSrIValNAHTFLRNGGHFLISIkANCID 278
************986332113334455555555554245665 PP
>> tr|H2QW55|H2QW55_PANTR PCMTD1 isoform 2 OS=Pan troglodytes OX=9598 GN=PCMTD1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.9 0.0 7.7e-06 0.02 30 86 .. 70 126 .. 60 141 .. 0.92
2 ? -0.8 0.0 0.49 1.3e+03 195 218 .. 304 327 .. 281 355 .. 0.49
Alignments for each domain:
== domain 1 score: 14.9 bits; conditional E-value: 7.7e-06
GCD14 30 sliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefr 86
s ++ L+l+pG ++ G G+g ls+ + ++P G + +e h + +e a+e+++
tr|H2QW55|H2QW55_PANTR 70 SEVMEALKLQPGLSFLNLGSGTGYLSTMVGLILGPFGINHGIELHSDVVEYAKEKLE 126
568899******************************************999998765 PP
== domain 2 score: -0.8 bits; conditional E-value: 0.49
GCD14 195 eenerkriekakrrkaskdakved 218
e+++ ++ +k +++k +++a + +
tr|H2QW55|H2QW55_PANTR 304 EDEKMEEDNKEEEEKDHNEAMKPE 327
222222222222333333322222 PP
>> tr|A0A2I3SHL6|A0A2I3SHL6_PANTR PCMTD2 isoform 5 OS=Pan troglodytes OX=9598 GN=PCMTD2 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 14.2 0.0 1.3e-05 0.033 30 84 .. 70 124 .. 54 147 .. 0.91
Alignments for each domain:
== domain 1 score: 14.2 bits; conditional E-value: 1.3e-05
GCD14 30 sliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekaree 84
s ++ L+l+pG ++ G G+g ls+ + ++P G + +e h + +e a+++
tr|A0A2I3SHL6|A0A2I3SHL6_PANTR 70 SEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNHGVELHSDVIEYAKQK 124
568899*****************************************99999885 PP
>> tr|A0A2I3TIN0|A0A2I3TIN0_PANTR Biogenesis of lysosome-related organelles complex 1 subunit 6 OS=Pan troglodytes OX=9
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 1.8 0.1 0.079 2e+02 142 179 .. 62 99 .. 46 114 .. 0.58
2 ? 6.2 4.9 0.0037 9.5 162 233 .. 101 175 .. 88 177 .] 0.69
Alignments for each domain:
== domain 1 score: 1.8 bits; conditional E-value: 0.079
GCD14 142 lCsfsPCieqvqrtceaLrelgfteietlevllrtyev 179
l + P +++ +++ ++L++ + + ++tle + +++
tr|A0A2I3TIN0|A0A2I3TIN0_PANTR 62 LSHYLPDLQRSKQALQELTQNQVVLLDTLEQEISKFKE 99
55555555555555555555555555566655555554 PP
== domain 2 score: 6.2 bits; conditional E-value: 0.0037
GCD14 162 lgfteietlevllrtyevrkskleeidlaekrleenerkriekakrrkaskdakvedkssks...stevllkPvs 233
+ +i++l ++y+++ +++++ l+ +++ ++ +kr+ k ++++++++ + e++++k ++++ ++P +
tr|A0A2I3TIN0|A0A2I3TIN0_PANTR 101 HSMLDINALFAEAKHYHAKLVNIRKEMLMLHEKTSKLKKRALKLQQKRQKEELEREQQREKEferEKQLTARPAK 175
67889******************9988866666666566666666666655555555554433446677788865 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (247 nodes)
Target sequences: 23008 (11942255 residues searched)
Passed MSV filter: 1257 (0.0546332); expected 460.2 (0.02)
Passed bias filter: 832 (0.0361613); expected 460.2 (0.02)
Passed Vit filter: 94 (0.00408554); expected 23.0 (0.001)
Passed Fwd filter: 18 (0.000782337); expected 0.2 (1e-05)
Initial search space (Z): 23008 [actual number of targets]
Domain search space (domZ): 9 [number of targets reported over threshold]
# CPU time: 0.39u 0.01s 00:00:00.40 Elapsed: 00:00:00.13
# Mc/sec: 22690.28
//
[ok]