# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file:                  pfam_list/GCD14.hmm.txt
# target sequence database:        proteomes/Strongylocentrotus_purpuratus.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query:       GCD14  [M=247]
Accession:   PF08704.9
Description: tRNA methyltransferase complex GCD14 subunit
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence               Description
    ------- ------ -----    ------- ------ -----   ---- --  --------               -----------
      1e-96  324.1   0.0    1.3e-96  323.7   0.0    1.1  1  tr|W4Y137|W4Y137_STRPU  tRNA (adenine(58)-N(1))-methyltransfe
    4.1e-16   60.1   0.4    5.2e-10   40.1   0.0    2.6  3  tr|W4ZGG3|W4ZGG3_STRPU  Uncharacterized protein OS=Strongyloc
    3.8e-06   27.4   0.0    5.7e-06   26.8   0.0    1.2  1  tr|W4ZAS4|W4ZAS4_STRPU  Uncharacterized protein OS=Strongyloc
  ------ inclusion threshold ------
      0.096   13.0   0.0       0.19   12.1   0.0    1.5  1  tr|W4YGK2|W4YGK2_STRPU  Protein-L-isoaspartate O-methyltransf
       0.14   12.5   0.0        0.2   12.0   0.0    1.2  1  tr|W4Z5B8|W4Z5B8_STRPU  Uncharacterized protein OS=Strongyloc
       0.38   11.1   5.2       0.59   10.4   5.2    1.3  1  tr|W4XSC1|W4XSC1_STRPU  Uncharacterized protein OS=Strongyloc
          3    8.1   7.3          4    7.7   7.3    1.3  1  tr|W4YEM5|W4YEM5_STRPU  Uncharacterized protein OS=Strongyloc


Domain annotation for each sequence (and alignments):
>> tr|W4Y137|W4Y137_STRPU  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Strongylocentrotus pur
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  323.7   0.0  3.2e-100   1.3e-96       1     246 [.      64     325 ..      64     326 .. 0.88

  Alignments for each domain:
  == domain 1  score: 323.7 bits;  conditional E-value: 3.2e-100
                   GCD14   1 gfvyvlaptPeLWtlaLphrtqilytaDisliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefre 87 
                             g+vyvl+ptPeLWt++Lphrtq+ly +Disl++ +LelkpGs vve+GtGsgs+sha++rt+aP Ghl+tfefhe+ra+ a +ef+e
  tr|W4Y137|W4Y137_STRPU  64 GWVYVLHPTPELWTVNLPHRTQVLYFPDISLLTIELELKPGSIVVEAGTGSGSVSHALTRTIAPDGHLYTFEFHEKRAKLAADEFKE 150
                             8************************************************************************************** PP

                   GCD14  88 helsqlvtvthrDvckeGfdeevsgkvDavfLDlPaPweaiphaakalkkeggrlCsfsPCieqvqrtceaLrelgfteietlevll 174
                             h+ls++vt thrDv ++Gf+ e + ++DavfLDlP+Pw  ipha+k+lk++ggr+CsfsPCieqvqr c +L +lgf +i+t+e l+
  tr|W4Y137|W4Y137_STRPU 151 HGLSHIVTATHRDVSQDGFQLENDYVADAVFLDLPSPWSVIPHAKKVLKSSGGRICSFSPCIEQVQRVCLELDQLGFSDIKTVECLM 237
                             *******************99999*************************************************************** PP

                   GCD14 175 rtyevrkskleeidlaekrleenerkriekakrrka...............skdakvedkssks.......stevllkPvselkght 239
                             rt+evr+++l+  +l++  l  n +++  + +  +                      e+  s+s        ++ +l P +e+ ght
  tr|W4Y137|W4Y137_STRPU 238 RTHEVRTVNLTLPNLGQPCLTPNITDHKAEEDTFELtdggarlvdlganysF-----EEPGSQSstgdcsyPKKCALAP-RETPGHT 318
                             ***************9999887766644444443334456666666433321.....2222222344444455666666.9****** PP

                   GCD14 240 gyLtfat 246
                             gyLtfa 
  tr|W4Y137|W4Y137_STRPU 319 GYLTFAS 325
                             *****96 PP

>> tr|W4ZGG3|W4ZGG3_STRPU  Uncharacterized protein OS=Strongylocentrotus purpuratus OX=7668 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   9.5e-07    0.0039      20      61 ..     255     296 ..     236     299 .. 0.82
   2 ?   -4.5   0.4       5.1   2.1e+04     196     213 ..     363     380 ..     344     397 .. 0.40
   3 !   40.1   0.0   1.3e-13   5.2e-10      20     180 ..     488     658 ..     469     679 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 9.5e-07
                   GCD14  20 rtqilytaDisliimkLelkpGsvvvesGtGsgslshaiart 61 
                                i y +D  ++ m+++  pG vv+e+G Gsgs++  + r+
  tr|W4ZGG3|W4ZGG3_STRPU 255 NPVIAYPKDCCTMLMMIDACPGDVVLEAGSGSGSMTLFLPRA 296
                             45688******************************9887775 PP

  == domain 2  score: -4.5 bits;  conditional E-value: 5.1
                   GCD14 196 enerkriekakrrkaskd 213
                             ++e+  +++++ ++ s++
  tr|W4ZGG3|W4ZGG3_STRPU 363 DVEKFDADETNSSRLSDS 380
                             222222222222222111 PP

  == domain 3  score: 40.1 bits;  conditional E-value: 1.3e-13
                   GCD14  20 rtqilytaDisliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfe...fheqraekareefreh.el......sqlvtv 96 
                                i y +D  ++ m+++  pG vv+e+G Gsgs++  ++r+v+  G++ +f+    h+ raek ++ ++   ++       q+v  
  tr|W4ZGG3|W4ZGG3_STRPU 488 NPVIAYPKDCCTMLMMIDACPGDVVLEAGSGSGSMTLFLSRAVGHHGKVLSFDklpTHQVRAEKNLKLWQTSyDIsnqvkwPQNVSF 574
                             45688***********************************************95556999999999888754244333233455666 PP

                   GCD14  97 thrDvckeGfdeev.sgkvDavfLDlPaPweaiphaakalkkeggrlCsfsPCieqvqrtceaLrelgftei..etlevllrtyevr 180
                             +   ++  G   ++ + +vD   +D+ +P   +  +++ l k+g  +  +   +  v   +e++r+     +  + lev  +++ v 
  tr|W4ZGG3|W4ZGG3_STRPU 575 YPSRLQDCGE--HIkDAQVDGAIIDMESPSTVMTTMSQRL-KSGKAMAVYVANLTLVIDLAEVIRKERLPLVteTILEVTHKEWVVN 658
                             6555555554..3314589*9**************99999.6777788888888888888888887665433115678888888776 PP

>> tr|W4ZAS4|W4ZAS4_STRPU  Uncharacterized protein OS=Strongylocentrotus purpuratus OX=7668 PE=3 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.8   0.0   1.4e-09   5.7e-06      35     150 ..     143     259 ..     135     270 .. 0.74

  Alignments for each domain:
  == domain 1  score: 26.8 bits;  conditional E-value: 1.4e-09
                   GCD14  35 kLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvc.keGfdeevsgkvDavfLD 120
                             ++++kpGs+v+  G+ sg+  + ++  v+P G ++++ef + r  + + +  +++  +++ +   D+   + + + + g vD+vf D
  tr|W4ZAS4|W4ZAS4_STRPU 143 HIHMKPGSKVLYLGAASGTTVSHVSDLVGPEGLVYAVEFSH-RSGRDLMNVAKKRT-NIIPI-IEDARhPHKY-RMLVGMVDCVFAD 225
                             5789****************9******************65.44444555544443.33444.4455525556.5677********* PP

                   GCD14 121 lPaPwea...iphaakalkkeggrlCsf.sPCie 150
                             + +P++a     +a + lk+eg  + s  + Ci+
  tr|W4ZAS4|W4ZAS4_STRPU 226 VAQPDQArivAINAHNFLKNEGHFVISIkANCID 259
                             ******9532235667788888877776256876 PP

>> tr|W4YGK2|W4YGK2_STRPU  Protein-L-isoaspartate O-methyltransferase OS=Strongylocentrotus purpuratus OX=7668 PE=3 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   4.6e-05      0.19      37      94 ..     170     227 ..     157     275 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 4.6e-05
                   GCD14  37 elkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlv 94 
                             +l +G  +++ G Gsg l++ +a  v+  G++  +++ ++ ++k+r++ ++++ + l+
  tr|W4YGK2|W4YGK2_STRPU 170 HLSEGKAALDVGSGSGYLTSCMAIMVGSSGKVVGIDHIKELVDKSRKNIEKDNPDLLT 227
                             578999*****************************************99988765544 PP

>> tr|W4Z5B8|W4Z5B8_STRPU  Uncharacterized protein OS=Strongylocentrotus purpuratus OX=7668 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   4.8e-05       0.2      40      88 ..      67     115 ..      61     135 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.8e-05
                   GCD14  40 pGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefreh 88 
                             + ++vv+ G G+g    ai++ v+P+G +  ++  +++ e ar+   +h
  tr|W4Z5B8|W4Z5B8_STRPU  67 EDARVVDLGSGTGRDCYAISKLVGPKGFVVGIDMTDEQLELARKYVTHH 115
                             5689**************************************9977766 PP

>> tr|W4XSC1|W4XSC1_STRPU  Uncharacterized protein OS=Strongylocentrotus purpuratus OX=7668 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   5.2   0.00014      0.59     168     243 ..      28     103 ..      18     107 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00014
                   GCD14 168 etlevllrtyevrkskleeidlaekrleenerkriekakrrkaskdakvedkssksstevllkPvselkghtgyLt 243
                             et e+   + e +k+k+ +i ++ +  ee++++r  + ++r++  ++++e+++ + ++e l k  +e + h  yL 
  tr|W4XSC1|W4XSC1_STRPU  28 ETSEIGCSRQEGKKRKVMTIWIMLQDREEEKERREAREEQRRKVTEKEKEEEEKREEEERLKKEEQEKRDHEEYLK 103
                             56677777788888888888885555555555555555555555555555555555899999999*********96 PP

>> tr|W4YEM5|W4YEM5_STRPU  Uncharacterized protein OS=Strongylocentrotus purpuratus OX=7668 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   7.3   0.00098         4     175     243 ..      63     131 ..      42     135 .. 0.70

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00098
                   GCD14 175 rtyevrkskleeidlaekrleenerkriekakrrkaskdakvedkssksstevllkPvselkghtgyLt 243
                             ++ e++ ++ +e +++ +  ee++++r  + ++r++  ++++e+++ + ++e l k  +e + h  yL 
  tr|W4YEM5|W4YEM5_STRPU  63 KKLEMKAERQREREIMLQDREEEKERREAREEQRRKVTEKEKEEEEKREEEERLKKEEQEKRDHEEYLK 131
                             5566677777777775554455545555555555554555555555555899999999*********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query model(s):                              1  (247 nodes)
Target sequences:                        28594  (14266044 residues searched)
Passed MSV filter:                      1810  (0.0633); expected 571.9 (0.02)
Passed bias filter:                     1145  (0.0400434); expected 571.9 (0.02)
Passed Vit filter:                       145  (0.00507099); expected 28.6 (0.001)
Passed Fwd filter:                        44  (0.00153878); expected 0.3 (1e-05)
Initial search space (Z):              28594  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.64u 0.02s 00:00:00.66 Elapsed: 00:00:00.19
# Mc/sec: 18545.86
//
[ok]