# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file:                  pfam_list/GCD14.hmm.txt
# target sequence database:        proteomes/Tetrahymena_thermophila.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query:       GCD14  [M=247]
Accession:   PF08704.9
Description: tRNA methyltransferase complex GCD14 subunit
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence               Description
    ------- ------ -----    ------- ------ -----   ---- --  --------               -----------
    4.2e-69  233.5   9.7    4.9e-64  216.9   0.1    3.0  3  tr|Q23UC8|Q23UC8_TETTS  tRNA (adenine(58)-N(1))-methyltransfe
    2.7e-06   27.8   0.0    3.7e-06   27.4   0.0    1.1  1  tr|I7MFA3|I7MFA3_TETTS  rRNA 2'-O-methyltransferase fibrillar
  ------ inclusion threshold ------
      0.022   15.0   0.0      0.056   13.7   0.0    1.6  2  tr|I7M9J8|I7M9J8_TETTS  NOL1/NOP2/Sun family protein OS=Tetra
       0.15   12.3   0.0       0.34   11.1   0.0    1.5  1  tr|Q23PZ6|Q23PZ6_TETTS  Cyclopropane-fatty-acyl-phospholipid 
       0.16   12.2   0.3       0.38   11.0   0.3    1.6  1  tr|W7XKT3|W7XKT3_TETTS  Uncharacterized protein OS=Tetrahymen
       0.59   10.3   0.0       0.59   10.3   0.0    3.1  3  tr|I7M7M0|I7M7M0_TETTS  Eukaryotic initiation factor 3, gamma
        3.4    7.8   7.9          9    6.5   7.9    1.7  1  tr|Q22A31|Q22A31_TETTS  tRNA-dihydrouridine synthase OS=Tetra
        4.5    7.4   4.7        5.1    7.3   4.7    1.1  1  tr|I7MFI9|I7MFI9_TETTS  Uncharacterized protein OS=Tetrahymen
        8.5    6.5   8.1         11    6.1   8.1    1.4  1  tr|W7X559|W7X559_TETTS  Uncharacterized protein OS=Tetrahymen


Domain annotation for each sequence (and alignments):
>> tr|Q23UC8|Q23UC8_TETTS  tRNA (adenine(58)-N(1))-methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   2.2      0.47   1.4e+03     196     226 ..      13      43 ..       2      68 .. 0.46
   2 !  216.9   0.1   1.6e-67   4.9e-64       2     222 ..     104     330 ..     103     344 .. 0.84
   3 !   21.1   0.1     1e-07    0.0003     188     245 ..     348     422 ..     334     424 .. 0.57

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.47
                   GCD14 196 enerkriekakrrkaskdakvedkssksste 226
                             e++ k+ +++ +++a++ a+ e k+s+ +++
  tr|Q23UC8|Q23UC8_TETTS  13 EQQVKNQNEQSQQSANQVANEEVKQSDNQQQ 43 
                             1111222222222222223333333332333 PP

  == domain 2  score: 216.9 bits;  conditional E-value: 1.6e-67
                   GCD14   2 fvyvlaptPeLWtlaLphrtqilytaDisliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefreh 88 
                             f+y+l+p P L t +L+h tqily+aDis +i k++++pGs vvesGtGs+sls++iart++  Ghl+tfef e+ra++  e +  +
  tr|Q23UC8|Q23UC8_TETTS 104 FIYLLRPDPVLITDTLSHLTQILYQADISYVISKMNIQPGSIVVESGTGSASLSSSIARTIQDEGHLYTFEFNEARAKNGAEVLAAQ 190
                             9************************************************************************************** PP

                   GCD14  89 elsqlvtvthrDvckeGf....deev....sgkvDavfLDlPaPweaiphaakalkkeggrlCsfsPCieqvqrtceaLrelgftei 167
                             +l+++  v  rDv ++Gf     e v    ++++DavfLDlP P+eai ha+++l k+ggrlC+fsPCieqv + ce++r ++f++i
  tr|Q23UC8|Q23UC8_TETTS 191 GLKNF-DVIWRDVLSNGFmpipGERVynlkEHSADAVFLDLPRPYEAITHAKQVL-KKGGRLCCFSPCIEQVMKNCEEMRIQKFVQI 275
                             *9865.8899********744334553333478**********************.99***************************** PP

                   GCD14 168 etlevllrtyevrkskleeidl.aekrleenerkriekakrrkaskdakvedkssk 222
                              t+ev +r +e r+++++ +    + +  +n+rkr  ++  + +++++ +ed++++
  tr|Q23UC8|Q23UC8_TETTS 276 VTIEVIQRPFERRERTFQSAFQvLNPNFINNKRKRD-EVGDNAQEQENIQEDQQQQ 330
                             ****************99876525555555555544.3333333444444444333 PP

  == domain 3  score: 21.1 bits;  conditional E-value: 1e-07
                   GCD14 188 dlaekrleenerkriekakrrkaskdakvedkssksstevllkPv.................selkghtgyLtfa 245
                             d+  + +ee+++++ +  k+ k++k++k+++++ + +++  +kP+                 +e+kghtgyL f 
  tr|Q23UC8|Q23UC8_TETTS 348 DEQGEDEEESQEEADQANKKGKQNKNNKKDKRNKQQNNQNGSKPIpqfirpqitkvvyssgpKEIKGHTGYLSFG 422
                             33333333333333333333333444444444444455666677677777777777777777**********995 PP

>> tr|I7MFA3|I7MFA3_TETTS  rRNA 2'-O-methyltransferase fibrillarin OS=Tetrahymena thermophila (strain SB210) OX=312017 G
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.4   0.0   1.2e-09   3.7e-06      34     148 ..     132     246 ..     115     267 .. 0.71

  Alignments for each domain:
  == domain 1  score: 27.4 bits;  conditional E-value: 1.2e-09
                   GCD14  34 mkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvckeGfdeevsgkvDavfLD 120
                               +++kpGs+v+  G  sg+  + +a  v+PtG ++++ef ++  +  ++  +++  +  +    r  ++  f   + g vD vf D
  tr|I7MFA3|I7MFA3_TETTS 132 SDIHIKPGSKVLYLGGASGTTVSHVADIVGPTGVVYAVEFSHRSGRDLVNMAKKRTNVVPIIGDARKPQEYRF---LVGMVDVVFAD 215
                             5689****************9999****************654444333333333223334446666677777...7799******* PP

                   GCD14 121 lPaPwea..iphaak.alkkeggrlCsfsPC 148
                             + +P++a  ++   +  lk+ g  l s   C
  tr|I7MFA3|I7MFA3_TETTS 216 VAQPDQAriMGMNCQyFLKNGGHFLISIKAC 246
                             *****99422333331346556666666543 PP

>> tr|I7M9J8|I7M9J8_TETTS  NOL1/NOP2/Sun family protein OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHERM_00
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       3.5   1.1e+04     174     202 ..      18      47 ..      12      74 .. 0.56
   2 ?   13.7   0.0   1.9e-05     0.056      33     123 ..     204     292 ..     196     298 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 3.5
                   GCD14 174 lrtyevrkskleeidl.aekrleenerkri 202
                             +++ e +k++ + id   +++l+en+    
  tr|I7M9J8|I7M9J8_TETTS  18 QQELELKKEQANPIDSmLRNYLKENKALGS 47 
                             555566666666555535555555544432 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 1.9e-05
                   GCD14  33 imkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrDvckeGfdeevsgkvDavfL 119
                              +k++ + G  v++  +G+g  s a+a  ++ tG+++  +  +   ++a++ f++ +++ +v+ ++++  ++   +++ +k D v  
  tr|I7M9J8|I7M9J8_TETTS 204 AFKVKCQIGDHVLDYCAGAGGKSLAFAPYLKGTGQIYLHDTRDYILQEAKKRFNKAGIQ-NVQFHTQESLNNNK-NKLVKKFDWVVC 288
                             57888999*************************************************95.68888888877765.788899****99 PP

                   GCD14 120 DlPa 123
                             D+P 
  tr|I7M9J8|I7M9J8_TETTS 289 DVPC 292
                             9995 PP

>> tr|Q23PZ6|Q23PZ6_TETTS  Cyclopropane-fatty-acyl-phospholipid synthase OS=Tetrahymena thermophila (strain SB210) OX=31
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00011      0.34      38      92 ..     148     201 ..     134     229 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00011
                   GCD14  38 lkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsq 92 
                               +G +v+e G G g   ++i+r ++P+   f ++f e+++++ r+ + +++  q
  tr|Q23PZ6|Q23PZ6_TETTS 148 NLNGLRVLEVGSGRGGGLNYISRYLNPQ-ECFGVDFSENQIRFCRHHYSQNKKLQ 201
                             5689***********************8.68****************99987555 PP

>> tr|W7XKT3|W7XKT3_TETTS  Uncharacterized protein OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHERM_0000916
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.3   0.00013      0.38     153     195 ..      12      54 ..       6      85 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00013
                   GCD14 153 qrtceaLrelgfteietlevllrtyevrkskleeidlaekrle 195
                             q  +++L+e+ f++ie++e ll++ +++ s++++ d + k  +
  tr|W7XKT3|W7XKT3_TETTS  12 QINIQKLSEQAFINIESIENLLQQIQTQYSQFQNFDYFGKDDK 54 
                             6689******************************999665554 PP

>> tr|I7M7M0|I7M7M0_TETTS  Eukaryotic initiation factor 3, gamma subunit OS=Tetrahymena thermophila (strain SB210) OX=31
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   5.0      0.21   6.4e+02     140     222 ..      16     101 ..       3     121 .. 0.58
   2 ?   -0.2   1.1      0.32   9.5e+02     188     230 ..     140     181 ..     112     207 .. 0.76
   3 ?   10.3   0.0    0.0002      0.59     130     189 ..     354     413 ..     347     419 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.21
                   GCD14 140 grlCsfsPCieqvqrtce.aLrelgfteietlevll.rtyevrkskleeidlaekrleener.kriekakrrkaskdakvedkssk 222
                             +r+     Ci+q q+ ++ +++ l+  eie  e++   + ++ +++++++ + ++++++++  k  e +  ++++++ k+ + +++
  tr|I7M7M0|I7M7M0_TETTS  16 TRFIYIQICIQQNQNKINpQINFLEMSEIEKQEIQPiIQENAEQQQVDQAPINQDNQQSDNViKGNEYVLLIDNRDNRKIVNLKEN 101
                             67777788******999735677788888888886413445566666666665554444433033333333444444443333333 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.32
                   GCD14 188 dlaekrleenerkriekakrrkaskdakvedkssksstevllk 230
                             + + +++e+ e+++ e++++r+  +d++v++ s++ + e++ k
  tr|I7M7M0|I7M7M0_TETTS 140 NQFYNYEENYEEEQSEQRDNRNIFNDNSVQKLSNE-EIELMKK 181
                             45667788888888888888888999988888887.4444433 PP

  == domain 3  score: 10.3 bits;  conditional E-value: 0.0002
                   GCD14 130 haakalkkeggrlCsfsPCieqvqrtceaLr.elgfteietlevllrtyevrkskleeidl 189
                             + ++     +g+l ++s  +e +q++ + ++ e +f++i+ +++ +r+++v k++ + i +
  tr|I7M7M0|I7M7M0_TETTS 354 KFMHL-LVPNGVLLAYSNYLECLQNSFDLMQqERDFVNIKIFDIFYREHQVLKNRTHPITM 413
                             44444.478999**************998752689***************99988776665 PP

>> tr|Q22A31|Q22A31_TETTS  tRNA-dihydrouridine synthase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHERM_01
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   7.9     0.003         9     158     239 ..      57     139 ..      46     150 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.003
                   GCD14 158 aLrelgfteietlevllrtyevrkskleeidlaekrleenerkriekakrrkaskdakvedks.sksstevllkPvselkght 239
                              L+e +f++i  + + + +++ ++++ +  d  +++++e ++++i ++ ++++ ++ ++e+++ ++ ++e+ ++ +se++ + 
  tr|Q22A31|Q22A31_TETTS  57 LLQEEQFQNIGIIFIKMDQNQQQNHNHNSQDQLIETTQELNKQQILNFTEESQANQMNQEQQNhQQQEEEIKVNNTSEIQNYK 139
                             58999***************************999999888888988887777665555554404445666666666665554 PP

>> tr|I7MFI9|I7MFI9_TETTS  Uncharacterized protein OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHERM_0066402
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   4.7    0.0017       5.1     167     227 ..      30      86 ..       6      99 .. 0.36

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0017
                   GCD14 167 ietlevllrtyevrkskleeidlaekrleenerkriekakrrkaskdakvedkssks.stev 227
                             ++ ++ + +++++ +  +++ +  ++ l++n++++ ++a++    +++++++++++  +++ 
  tr|I7MFI9|I7MFI9_TETTS  30 LNNVDQQPNNNNINQPLINNQNNNNN-LNNNNNNSNNNANN----NNNNINNNNNNNnNNNN 86 
                             23333333333333333333332222.22222222222222....22222222211112233 PP

>> tr|W7X559|W7X559_TETTS  Uncharacterized protein OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHERM_0003835
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   8.1    0.0038        11     157     232 ..      27     100 ..      10     131 .. 0.64

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0038
                   GCD14 157 eaLrelgfteietlevllrtyevrkskleeidlaekrleenerkriekakrrkaskdakvedkssksstevllkPv 232
                             ++ +++   ei+ +e+ l++ e ++ + ++ +  ++ ++++++kr  k k r    ++k+ +++s+s++++ +k +
  tr|W7X559|W7X559_TETTS  27 KECSQQTEAEINFVEIELQRLEKHTDNNKKGNKKNEGENQDKEKRKIKEKIRTR--ETKKMKEKSRSQETIQMKKI 100
                             445555667999999999999988888888877666666665554443333333..23333333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query model(s):                              1  (247 nodes)
Target sequences:                        26971  (16912921 residues searched)
Passed MSV filter:                      7237  (0.268325); expected 539.4 (0.02)
Passed bias filter:                     1794  (0.0665159); expected 539.4 (0.02)
Passed Vit filter:                       244  (0.00904675); expected 27.0 (0.001)
Passed Fwd filter:                        85  (0.00315153); expected 0.3 (1e-05)
Initial search space (Z):              26971  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 1.41u 0.03s 00:00:01.44 Elapsed: 00:00:00.38
# Mc/sec: 10993.40
//
[ok]