# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/MT-A70.hmm.txt
# target sequence database: proteomes/Homo_sapiens.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: MT-A70 [M=172]
Accession: PF05063.13
Description: MT-A70
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
2.6e-63 215.2 1.1 8.4e-63 213.6 0.0 1.9 2 tr|D6RBL4|D6RBL4_HUMAN Methyltransferase-like protein 14 OS
7.2e-63 213.8 0.0 1e-62 213.3 0.0 1.2 1 sp|Q9HCE5|MET14_HUMAN Methyltransferase-like protein 14 OS
4.6e-60 204.7 0.0 8.7e-60 203.8 0.0 1.5 1 sp|Q86U44|MTA70_HUMAN N6-adenosine-methyltransferase 70 kD
1.2e-38 135.0 0.5 3.1e-38 133.6 0.1 1.8 2 sp|Q8N3J2|METL4_HUMAN Methyltransferase-like protein 4 OS=
2.8e-36 127.3 0.1 3.7e-36 126.9 0.1 1.1 1 sp|Q86U44-2|MTA70_HUMAN Isoform 2 of N6-adenosine-methyltran
1.4e-24 89.2 0.5 4.4e-24 87.6 0.1 2.0 2 tr|J3KNJ7|J3KNJ7_HUMAN Methyltransferase-like protein 4 OS=
1.7e-19 72.7 1.8 2e-19 72.4 1.8 1.0 1 tr|I3L3W2|I3L3W2_HUMAN Methyltransferase-like protein 4 (Fr
Domain annotation for each sequence (and alignments):
>> tr|D6RBL4|D6RBL4_HUMAN Methyltransferase-like protein 14 OS=Homo sapiens GN=METTL14 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 0.1 0.2 0.26 3.3e+03 24 58 .. 5 38 .. 2 55 .. 0.71
2 ! 213.6 0.0 6.6e-67 8.4e-63 1 171 [. 148 324 .. 148 325 .. 0.96
Alignments for each domain:
== domain 1 score: 0.1 bits; conditional E-value: 0.26
--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHH CS
MT-A70 24 ktlneeelkaLpipelldkrslvflWvtnrellel 58
k l++e+l Lp+ ll+ + v +W+ r++ +
tr|D6RBL4|D6RBL4_HUMAN 5 KLLKQEKLAGLPMIPLLQMQ-NVSIWMKERQMKTK 38
56778888888876666665.58888888888766 PP
== domain 2 score: 213.6 bits; conditional E-value: 6.6e-67
ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHHHHHHHHHCT-EEEEEEEEEEE-TTSCBS- CS
MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellelkrellkkWglelveeltwlkinklgepia 87
fdvi+++Pp+ee++++ ++++k+++++++++L+i+e++++rs++flW+++ e+l+l+r++l+kWg++++e+++w+k+n +++p++
tr|D6RBL4|D6RBL4_HUMAN 148 FDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTN-KNNPGK 233
9*************66555*************************************************************.556555 PP
..BS-TTSSSBB-EEEEEEEEES---TTT.T.TB-TTSSBSEEEE..E-CTTTSS-THHHHHHHHHCTCS-EEEET--G..--TTEE CS
MT-A70 88 ..tlesgavlkkskEhllvgvkgnvkrstdk.iinknvdtdliis..perehsrKPpelfellehllesarkLelFaRs..lrpgwl 167
tl+++av++++kEh+l+g+kg+vkrstd+ +i++nvd+dlii+ pe+++++KP e+f+++eh++ ++r+L+lF+R+ +rpgwl
tr|D6RBL4|D6RBL4_HUMAN 234 tkTLDPKAVFQRTKEHCLMGIKGTVKRSTDGdFIHANVDIDLIITeePEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDstIRPGWL 320
569******************************************999*************************************** PP
EEET CS
MT-A70 168 tvGn 171
tvG+
tr|D6RBL4|D6RBL4_HUMAN 321 TVGP 324
***7 PP
>> sp|Q9HCE5|MET14_HUMAN Methyltransferase-like protein 14 OS=Homo sapiens GN=METTL14 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 213.3 0.0 8.1e-67 1e-62 1 171 [. 186 362 .. 186 363 .. 0.96
Alignments for each domain:
== domain 1 score: 213.3 bits; conditional E-value: 8.1e-67
ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHHHHHHHHHCT-EEEEEEEEEEE-TTSCBS-. CS
MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellelkrellkkWglelveeltwlkinklgepia. 87
fdvi+++Pp+ee++++ ++++k+++++++++L+i+e++++rs++flW+++ e+l+l+r++l+kWg++++e+++w+k+n +++p++
sp|Q9HCE5|MET14_HUMAN 186 FDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTN-KNNPGKt 272
9*************66555*************************************************************.5565555 PP
.BS-TTSSSBB-EEEEEEEEES---TTT.T.TB-TTSSBSEEEE..E-CTTTSS-THHHHHHHHHCTCS-EEEET--G..--TTEEEE CS
MT-A70 88 .tlesgavlkkskEhllvgvkgnvkrstdk.iinknvdtdliis..perehsrKPpelfellehllesarkLelFaRs..lrpgwltv 169
tl+++av++++kEh+l+g+kg+vkrstd+ +i++nvd+dlii+ pe+++++KP e+f+++eh++ ++r+L+lF+R+ +rpgwltv
sp|Q9HCE5|MET14_HUMAN 273 kTLDPKAVFQRTKEHCLMGIKGTVKRSTDGdFIHANVDIDLIITeePEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDstIRPGWLTV 360
69******************************************999***************************************** PP
ET CS
MT-A70 170 Gn 171
G+
sp|Q9HCE5|MET14_HUMAN 361 GP 362
*7 PP
>> sp|Q86U44|MTA70_HUMAN N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 203.8 0.0 6.9e-64 8.7e-60 1 172 [] 389 550 .. 389 550 .. 0.98
Alignments for each domain:
== domain 1 score: 203.8 bits; conditional E-value: 6.9e-64
ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHHHHHHHHHCT-EEEEEEEEEEE-TTSCBS-B CS
MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellelkrellkkWglelveeltwlkinklgepiat 88
f+v+++dPpw++++ elpy+tl+++e+++L+ip+l+d++ ++flWvt+r+++ + re+l+ Wg+e+v+e++w+k+n+l+++i+t
sp|Q86U44|MTA70_HUMAN 389 FAVVMADPPWDIHM-----ELPYGTLTDDEMRRLNIPVLQDDG-FLFLWVTGRAMELG-RECLNLWGYERVDEIIWVKTNQLQRIIRT 469
89************.....9*********************99.*************9.***************************** PP
S-TTSSSBB-EEEEEEEEES---TTT.TTB-TTSSBSEEEEE-CTTTSS-THHHHHHHHHCTCS-EEEET--G..--TTEEEEETT CS
MT-A70 89 lesgavlkkskEhllvgvkgnvkrstdkiinknvdtdliisperehsrKPpelfellehllesarkLelFaRs..lrpgwltvGne 172
+++g++l++ kEh+lvgvkgn++ +n++ d+d+i++++r++s+KP+e++ ++e+l++++rk+elF+R ++p+w+t+Gn+
sp|Q86U44|MTA70_HUMAN 470 GRTGHWLNHGKEHCLVGVKGNPQ-----GFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPhnVQPNWITLGNQ 550
**********************8.....67899***************************************999*********97 PP
>> sp|Q8N3J2|METL4_HUMAN Methyltransferase-like protein 4 OS=Homo sapiens GN=METTL4 PE=2 SV=3
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -1.4 0.0 0.77 9.7e+03 91 112 .. 106 127 .. 94 144 .. 0.72
2 ! 133.6 0.1 2.5e-42 3.1e-38 1 172 [] 281 455 .. 281 455 .. 0.92
Alignments for each domain:
== domain 1 score: -1.4 bits; conditional E-value: 0.77
TTSSSBB-EEEEEEEEES---T CS
MT-A70 91 sgavlkkskEhllvgvkgnvkr 112
+ + + kE l+ gvk++ +
sp|Q8N3J2|METL4_HUMAN 106 KECQQSNEKEDLMNGVKKEISI 127
4445667899999999999864 PP
== domain 2 score: 133.6 bits; conditional E-value: 2.5e-42
ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHH..HHHHHHHCT-EEEEEEEEEEE-TTSCBS CS
MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellel..krellkkWglelveeltwlkinklgepi 86
fdvi+idPpw++k+v+r++ +y+ l+ +++++pip+l+++++l++ Wvtnr+++ k+el ++W +e+v+e+ w+ki++ ge +
sp|Q8N3J2|METL4_HUMAN 281 FDVIVIDPPWQNKSVKRSN--RYSYLSPLQIQQIPIPKLAAPNCLLVTWVTNRQKHLRfiKEELYPSWSVEVVAEWHWVKITNSGEFV 366
9*****************8..9***********************************99999************************** PP
-BS-TTSSSBB-EEEEEEEEES---TTT.TTB-TTS....SBSEEEE.E-CTTTSS-THHHHHHHHHCTCS-EEEET--G--TTEEEE CS
MT-A70 87 atlesgavlkkskEhllvgvkgnvkrstdkiinknv....dtdliis.perehsrKPpelfellehllesarkLelFaRslrpgwltv 169
++l+s +kk++E l++g ++ ++ + nv d +li+s p + hs+KPp+ l + ++ + LelFaR+l+pgw+++
sp|Q8N3J2|METL4_HUMAN 367 FPLDSP--HKKPYEGLILGRVQEKTALPLRNADVNVlpipDHKLIVSvPCTLHSHKPPLAEVLKDYIKPDGEYLELFARNLQPGWTSW 452
*98888..99*********88877765544444444778999*****99*********9999999999******************** PP
ETT CS
MT-A70 170 Gne 172
Gne
sp|Q8N3J2|METL4_HUMAN 453 GNE 455
*97 PP
>> sp|Q86U44-2|MTA70_HUMAN Isoform 2 of N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 126.9 0.1 2.9e-40 3.7e-36 1 110 [. 105 207 .. 105 219 .. 0.94
Alignments for each domain:
== domain 1 score: 126.9 bits; conditional E-value: 2.9e-40
ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHHHHHHHHHCT-EEEEEEEEEEE-TTSCBS CS
MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellelkrellkkWglelveeltwlkinklgepi 86
f+v+++dPpw++++ elpy+tl+++e+++L+ip+l+d++ ++flWvt+r+++ + re+l+ Wg+e+v+e++w+k+n+l+++i
sp|Q86U44-2|MTA70_HUMAN 105 FAVVMADPPWDIHM-----ELPYGTLTDDEMRRLNIPVLQDDG-FLFLWVTGRAMELG-RECLNLWGYERVDEIIWVKTNQLQRII 183
89************.....9*********************99.*************9.*************************** PP
-BS-TTSSSBB-EEEEEEEEES-- CS
MT-A70 87 atlesgavlkkskEhllvgvkgnv 110
+t+++g++l++ kEh+lv+ g
sp|Q86U44-2|MTA70_HUMAN 184 RTGRTGHWLNHGKEHCLVSSSGAQ 207
******************987755 PP
>> tr|J3KNJ7|J3KNJ7_HUMAN Methyltransferase-like protein 4 OS=Homo sapiens GN=METTL4 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -1.2 0.0 0.65 8.2e+03 91 112 .. 106 127 .. 94 145 .. 0.72
2 ! 87.6 0.1 3.5e-28 4.4e-24 1 108 [. 281 386 .. 281 402 .. 0.95
Alignments for each domain:
== domain 1 score: -1.2 bits; conditional E-value: 0.65
TTSSSBB-EEEEEEEEES---T CS
MT-A70 91 sgavlkkskEhllvgvkgnvkr 112
+ + + kE l+ gvk++ +
tr|J3KNJ7|J3KNJ7_HUMAN 106 KECQQSNEKEDLMNGVKKEISI 127
4445667899999999999864 PP
== domain 2 score: 87.6 bits; conditional E-value: 3.5e-28
ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHH..HHHHHHHCT-EEEEEEEEEEE-TTSCB CS
MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellel..krellkkWglelveeltwlkinklgep 85
fdvi+idPpw++k+v+r++ +y+ l+ +++++pip+l+++++l++ Wvtnr+++ k+el ++W +e+v+e+ w+ki++ ge
tr|J3KNJ7|J3KNJ7_HUMAN 281 FDVIVIDPPWQNKSVKRSN--RYSYLSPLQIQQIPIPKLAAPNCLLVTWVTNRQKHLRfiKEELYPSWSVEVVAEWHWVKITNSGEF 365
9*****************8..9***********************************99999************************* PP
S-BS-TTSSSBB-EEEEEEEEES CS
MT-A70 86 iatlesgavlkkskEhllvgvkg 108
+++l+s +kk++E l++g +
tr|J3KNJ7|J3KNJ7_HUMAN 366 VFPLDSP--HKKPYEGLILGRVQ 386
**98888..99*******99655 PP
>> tr|I3L3W2|I3L3W2_HUMAN Methyltransferase-like protein 4 (Fragment) OS=Homo sapiens GN=METTL4 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 72.4 1.8 1.6e-23 2e-19 1 78 [. 13 90 .. 13 91 .. 0.98
Alignments for each domain:
== domain 1 score: 72.4 bits; conditional E-value: 1.6e-23
ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHH..HHHHHHHCT-EEEEEEEEEE CS
MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellel..krellkkWglelveeltwlk 78
fdvi+idPpw++k+v+r++ +y+ l+ +++++pip+l+++++l++ Wvtnr+++ k+el ++W +e+v+e+ w+k
tr|I3L3W2|I3L3W2_HUMAN 13 FDVIVIDPPWQNKSVKRSN--RYSYLSPLQIQQIPIPKLAAPNCLLVTWVTNRQKHLRfiKEELYPSWSVEVVAEWHWVK 90
9*****************8..9***********************************99999*****************9 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (172 nodes)
Target sequences: 88473 (35070517 residues searched)
Passed MSV filter: 2020 (0.0228318); expected 1769.5 (0.02)
Passed bias filter: 1444 (0.0163214); expected 1769.5 (0.02)
Passed Vit filter: 100 (0.00113029); expected 88.5 (0.001)
Passed Fwd filter: 7 (7.91202e-05); expected 0.9 (1e-05)
Initial search space (Z): 88473 [actual number of targets]
Domain search space (domZ): 7 [number of targets reported over threshold]
# CPU time: 0.44u 0.03s 00:00:00.47 Elapsed: 00:00:00.23
# Mc/sec: 26226.65
//
[ok]