# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/MT-A70.hmm.txt # target sequence database: proteomes/Mus_musculus.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: MT-A70 [M=172] Accession: PF05063.13 Description: MT-A70 Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 1.8e-63 213.8 0.0 2.6e-63 213.3 0.0 1.2 1 sp|Q3UIK4|MET14_MOUSE N6-adenosine-methyltransferase non-cat 1.2e-60 204.7 0.0 2.2e-60 203.8 0.0 1.5 1 sp|Q8C3P7|MTA70_MOUSE N6-adenosine-methyltransferase subunit 5.9e-40 137.3 0.1 9.6e-40 136.6 0.1 1.3 1 sp|Q3U034|METL4_MOUSE Methyltransferase-like protein 4 OS=Mu Domain annotation for each sequence (and alignments): >> sp|Q3UIK4|MET14_MOUSE N6-adenosine-methyltransferase non-catalytic subunit OS=Mus musculus OX=10090 GN=Mettl14 PE=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 213.3 0.0 3.5e-67 2.6e-63 1 171 [. 186 362 .. 186 363 .. 0.96 Alignments for each domain: == domain 1 score: 213.3 bits; conditional E-value: 3.5e-67 ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHHHHHHHHHCT-EEEEEEEEEEE-TTSCBS-. CS MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellelkrellkkWglelveeltwlkinklgepia. 87 fdvi+++Pp+ee++++ ++++k+++++++++L+i+e++++rs++flW+++ e+l+l+r++l+kWg++++e+++w+k+n +++p++ sp|Q3UIK4|MET14_MOUSE 186 FDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTN-KNNPGKt 272 9*************66555*************************************************************.5565555 PP .BS-TTSSSBB-EEEEEEEEES---TTT.T.TB-TTSSBSEEEE..E-CTTTSS-THHHHHHHHHCTCS-EEEET--G..--TTEEEE CS MT-A70 88 .tlesgavlkkskEhllvgvkgnvkrstdk.iinknvdtdliis..perehsrKPpelfellehllesarkLelFaRs..lrpgwltv 169 tl+++av++++kEh+l+g+kg+vkrstd+ +i++nvd+dlii+ pe+++++KP e+f+++eh++ ++r+L+lF+R+ +rpgwltv sp|Q3UIK4|MET14_MOUSE 273 kTLDPKAVFQRTKEHCLMGIKGTVKRSTDGdFIHANVDIDLIITeePEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDstIRPGWLTV 360 69******************************************999***************************************** PP ET CS MT-A70 170 Gn 171 G+ sp|Q3UIK4|MET14_MOUSE 361 GP 362 *7 PP >> sp|Q8C3P7|MTA70_MOUSE N6-adenosine-methyltransferase subunit METTL3 OS=Mus musculus OX=10090 GN=Mettl3 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 203.8 0.0 3e-64 2.2e-60 1 172 [] 389 550 .. 389 550 .. 0.98 Alignments for each domain: == domain 1 score: 203.8 bits; conditional E-value: 3e-64 ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHHHHHHHHHCT-EEEEEEEEEEE-TTSCBS-B CS MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellelkrellkkWglelveeltwlkinklgepiat 88 f+v+++dPpw++++ elpy+tl+++e+++L+ip+l+d++ ++flWvt+r+++ + re+l+ Wg+e+v+e++w+k+n+l+++i+t sp|Q8C3P7|MTA70_MOUSE 389 FAVVMADPPWDIHM-----ELPYGTLTDDEMRRLNIPVLQDDG-FLFLWVTGRAMELG-RECLNLWGYERVDEIIWVKTNQLQRIIRT 469 89************.....9*********************99.*************9.***************************** PP S-TTSSSBB-EEEEEEEEES---TTT.TTB-TTSSBSEEEEE-CTTTSS-THHHHHHHHHCTCS-EEEET--G..--TTEEEEETT CS MT-A70 89 lesgavlkkskEhllvgvkgnvkrstdkiinknvdtdliisperehsrKPpelfellehllesarkLelFaRs..lrpgwltvGne 172 +++g++l++ kEh+lvgvkgn++ +n++ d+d+i++++r++s+KP+e++ ++e+l++++rk+elF+R ++p+w+t+Gn+ sp|Q8C3P7|MTA70_MOUSE 470 GRTGHWLNHGKEHCLVGVKGNPQ-----GFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPhnVQPNWITLGNQ 550 **********************8.....67899***************************************999*********97 PP >> sp|Q3U034|METL4_MOUSE Methyltransferase-like protein 4 OS=Mus musculus OX=10090 GN=Mettl4 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 136.6 0.1 1.3e-43 9.6e-40 1 172 [] 280 454 .. 280 454 .. 0.92 Alignments for each domain: == domain 1 score: 136.6 bits; conditional E-value: 1.3e-43 ECEEEE---BHHCC..HTT--SS--B-HHHHHTS-GGGCECCEEEEEEEEETTCHHHH..HHHHHHHCT-EEEEEEEEEEE-TTSCBS CS MT-A70 1 fdviiidPpweeklvarkkelpyktlneeelkaLpipelldkrslvflWvtnrellel..krellkkWglelveeltwlkinklgepi 86 fd i+idPpwe+k+v+r++ +y+ l+ +++k++pip+l+++++l++ Wvtnr+++ k+el ++W +e+v+e+ w+ki++ ge + sp|Q3U034|METL4_MOUSE 280 FDAIVIDPPWENKSVKRSN--RYSSLSPQQIKRMPIPKLAAADCLIVTWVTNRQKHLCfvKEELYPSWSVEVVAEWYWVKITNSGEFV 365 899***************8..***********************************999999************************** PP -BS-TTSSSBB-EEEEEEEEES---TTT.TTB-TTS....SBSEEEE.E-CTTTSS-THHHHHHHHHCTCS-EEEET--G--TTEEEE CS MT-A70 87 atlesgavlkkskEhllvgvkgnvkrstdkiinknv....dtdliis.perehsrKPpelfellehllesarkLelFaRslrpgwltv 169 ++l+s +kk++E l++g ++ + + ++ + d++li+s p hs+KPp+ l+ + ++ ++LelFaR+l+pgw+++ sp|Q3U034|METL4_MOUSE 366 FPLDSP--HKKPYECLVLGRVKEKTPLALRNPDVRIppvpDQKLIVSvPCVLHSHKPPLTEVLRDYIKPGGQCLELFARNLQPGWMSW 451 *98888..99*********8777765554444444466789******999********9999999999******************** PP ETT CS MT-A70 170 Gne 172 Gne sp|Q3U034|METL4_MOUSE 452 GNE 454 *97 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (172 nodes) Target sequences: 22289 (11757923 residues searched) Passed MSV filter: 528 (0.0236888); expected 445.8 (0.02) Passed bias filter: 370 (0.0166001); expected 445.8 (0.02) Passed Vit filter: 27 (0.00121136); expected 22.3 (0.001) Passed Fwd filter: 3 (0.000134596); expected 0.2 (1e-05) Initial search space (Z): 22289 [actual number of targets] Domain search space (domZ): 3 [number of targets reported over threshold] # CPU time: 0.15u 0.01s 00:00:00.16 Elapsed: 00:00:00.08 # Mc/sec: 25279.53 // [ok]