# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Met_10.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Met_10 [M=199] Accession: PF02475.15 Description: Met-10+ like-protein Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 6.8e-62 211.0 0.0 2.2e-61 209.4 0.0 1.8 2 sp|Q32P41|TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransfer 1.2e-29 105.8 0.0 1.8e-29 105.2 0.0 1.2 1 sp|Q53H54|TYW2_HUMAN tRNA wybutosine-synthesizing protein 1.3e-05 27.3 0.0 2.3e-05 26.5 0.0 1.3 1 sp|Q9NXH9-2|TRM1_HUMAN Isoform 2 of tRNA (guanine(26)-N(2)) 1.4e-05 27.2 0.0 2.5e-05 26.4 0.0 1.3 1 sp|Q9NXH9|TRM1_HUMAN tRNA (guanine(26)-N(2))-dimethyltran 2.1e-05 26.6 0.0 5.3e-05 25.3 0.0 1.6 1 sp|Q96RS0|TGS1_HUMAN Trimethylguanosine synthase OS=Homo 4.6e-05 25.5 0.0 7.2e-05 24.9 0.0 1.3 1 tr|K7EQQ8|K7EQQ8_HUMAN tRNA (guanine(26)-N(2))-dimethyltran 0.00012 24.1 0.1 0.00028 23.0 0.1 1.7 1 sp|Q7Z2T5-2|TRM1L_HUMAN Isoform 2 of TRMT1-like protein OS=H 0.00047 22.2 0.1 0.0011 21.0 0.1 1.6 1 sp|Q7Z2T5|TRM1L_HUMAN TRMT1-like protein OS=Homo sapiens G 0.0005 22.1 0.0 0.00069 21.7 0.0 1.2 1 sp|Q8IXQ9|MET20_HUMAN Methyltransferase-like protein 20 OS 0.0005 22.1 0.1 0.00061 21.8 0.1 1.1 1 tr|E9PNR9|E9PNR9_HUMAN Protein arginine N-methyltransferase 0.00051 22.1 0.0 0.00071 21.6 0.0 1.2 1 sp|Q96LA8|ANM6_HUMAN Protein arginine N-methyltransferase 0.0008 21.5 0.0 0.0011 21.1 0.0 1.1 1 tr|H7C2H9|H7C2H9_HUMAN Protein arginine N-methyltransferase 0.00085 21.4 0.0 0.0011 21.0 0.0 1.2 1 tr|E9PQ98|E9PQ98_HUMAN Protein arginine N-methyltransferase 0.00088 21.3 0.0 0.0012 20.9 0.0 1.2 1 tr|E9PIX6|E9PIX6_HUMAN Protein arginine N-methyltransferase 0.001 21.1 0.0 0.0018 20.3 0.0 1.3 1 sp|Q9NR22-2|ANM8_HUMAN Isoform 2 of Protein arginine N-meth 0.0011 21.1 0.0 0.0019 20.3 0.0 1.3 1 sp|Q9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 0.0012 20.9 0.2 0.0036 19.3 0.0 1.9 1 sp|O60678-2|ANM3_HUMAN Isoform 2 of Protein arginine N-meth 0.0012 20.9 0.1 0.0017 20.4 0.1 1.1 1 tr|H0YDE4|H0YDE4_HUMAN Protein arginine N-methyltransferase 0.0014 20.7 0.0 0.002 20.2 0.0 1.2 1 tr|B7U630|B7U630_HUMAN PRMT2 alpha variant OS=Homo sapiens 0.0015 20.6 0.0 0.0044 19.1 0.0 1.7 1 sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 0.0021 20.1 0.1 0.0033 19.5 0.1 1.2 1 tr|E9PKG1|E9PKG1_HUMAN Protein arginine N-methyltransferase 0.0023 20.0 0.1 0.0036 19.3 0.1 1.2 1 sp|Q99873-3|ANM1_HUMAN Isoform 3 of Protein arginine N-meth 0.0023 20.0 0.1 0.0037 19.3 0.1 1.2 1 sp|Q99873-2|ANM1_HUMAN Isoform 2 of Protein arginine N-meth 0.0024 19.9 0.0 0.0033 19.5 0.0 1.1 1 tr|B7U632|B7U632_HUMAN PRMT2 gamma variant OS=Homo sapiens 0.0024 19.9 0.1 0.0038 19.3 0.1 1.2 1 sp|Q99873-4|ANM1_HUMAN Isoform 4 of Protein arginine N-meth 0.0025 19.9 0.1 0.004 19.2 0.1 1.2 1 sp|Q99873|ANM1_HUMAN Protein arginine N-methyltransferase 0.0025 19.8 0.0 0.0042 19.1 0.0 1.2 1 sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyl 0.0026 19.8 0.1 0.0042 19.1 0.1 1.2 1 tr|H7C2I1|H7C2I1_HUMAN Protein arginine N-methyltransferase 0.0026 19.8 0.0 0.0033 19.4 0.0 1.1 1 tr|D6RCL3|D6RCL3_HUMAN Probable dimethyladenosine transfera 0.0026 19.8 0.0 0.0038 19.2 0.0 1.2 1 tr|B7U631|B7U631_HUMAN PRMT2 beta variant OS=Homo sapiens G 0.0028 19.7 0.0 0.0043 19.1 0.0 1.2 1 sp|P55345|ANM2_HUMAN Protein arginine N-methyltransferase 0.0029 19.6 0.0 0.0049 18.9 0.0 1.2 1 sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase h 0.0031 19.6 0.0 0.0044 19.1 0.0 1.1 1 tr|A8MXR3|A8MXR3_HUMAN Protein arginine N-methyltransferase 0.0031 19.6 0.0 0.0041 19.1 0.0 1.1 1 sp|P55345-2|ANM2_HUMAN Isoform 2 of Protein arginine N-meth 0.0034 19.4 0.0 0.0048 18.9 0.0 1.2 1 sp|P55345-3|ANM2_HUMAN Isoform 3 of Protein arginine N-meth ------ inclusion threshold ------ 0.01 17.9 0.0 0.016 17.2 0.0 1.3 1 sp|Q9UNQ2|DIM1_HUMAN Probable dimethyladenosine transfera 0.014 17.4 0.0 0.031 16.3 0.0 1.5 1 tr|B3KU92|B3KU92_HUMAN Putative protein arginine N-methyltr 0.017 17.1 0.0 0.038 16.0 0.0 1.5 1 sp|Q6P2P2|ANM10_HUMAN Putative protein arginine N-methyltr 0.022 16.7 0.0 0.032 16.3 0.0 1.2 1 tr|A8MTP3|A8MTP3_HUMAN Protein arginine N-methyltransferase 0.024 16.6 0.0 0.04 15.9 0.0 1.3 1 tr|B4DV00|B4DV00_HUMAN Protein arginine N-methyltransferase 0.026 16.6 0.0 0.048 15.7 0.0 1.5 1 tr|K7EQA8|K7EQA8_HUMAN Histone-arginine methyltransferase C 0.028 16.4 0.0 0.046 15.7 0.0 1.3 1 tr|B4DX49|B4DX49_HUMAN Protein arginine N-methyltransferase 0.03 16.3 0.0 0.049 15.6 0.0 1.3 1 tr|G3V5W5|G3V5W5_HUMAN Protein arginine N-methyltransferase 0.03 16.3 0.0 0.066 15.2 0.0 1.5 1 sp|Q86X55-2|CARM1_HUMAN Isoform 2 of Histone-arginine methyl 0.032 16.2 0.0 0.054 15.5 0.0 1.3 1 sp|O14744-2|ANM5_HUMAN Isoform 2 of Protein arginine N-meth 0.034 16.2 0.0 0.056 15.4 0.0 1.3 1 sp|O14744|ANM5_HUMAN Protein arginine N-methyltransferase 0.07 15.1 0.0 0.14 14.2 0.0 1.5 1 sp|Q86X55-1|CARM1_HUMAN Isoform 1 of Histone-arginine methyl 0.075 15.0 0.0 0.15 14.1 0.0 1.5 1 sp|Q86X55|CARM1_HUMAN Histone-arginine methyltransferase C 0.1 14.6 0.0 0.14 14.1 0.0 1.1 1 tr|H0Y768|H0Y768_HUMAN tRNA (guanine(10)-N2)-methyltransfer 0.11 14.4 0.0 0.19 13.7 0.0 1.4 1 tr|B8ZZE3|B8ZZE3_HUMAN Methyltransferase like 5, isoform CR 0.12 14.3 0.0 0.21 13.6 0.0 1.4 1 sp|Q9NRN9|METL5_HUMAN Methyltransferase-like protein 5 OS= 0.16 13.9 0.0 0.2 13.7 0.0 1.1 1 tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS= 0.19 13.7 0.0 0.39 12.7 0.0 1.4 1 tr|B8ZZC8|B8ZZC8_HUMAN Methyltransferase-like protein 5 OS= 0.23 13.4 0.0 49 5.9 0.0 2.3 2 tr|H3BNC0|H3BNC0_HUMAN Protein arginine N-methyltransferase 0.23 13.4 0.0 49 5.9 0.0 2.3 2 sp|Q9NVM4-4|ANM7_HUMAN Isoform 4 of Protein arginine N-meth 0.28 13.2 0.0 0.48 12.4 0.0 1.3 1 tr|F2Z2Q4|F2Z2Q4_HUMAN tRNA (guanine(10)-N2)-methyltransfer 0.32 13.0 0.0 0.55 12.2 0.0 1.3 1 sp|P46087-3|NOP2_HUMAN Isoform 3 of Putative ribosomal RNA 0.38 12.7 0.0 58 5.6 0.0 2.3 2 sp|Q9NVM4|ANM7_HUMAN Protein arginine N-methyltransferase 0.42 12.6 0.0 0.73 11.8 0.0 1.3 1 sp|Q7Z4G4-2|TRM11_HUMAN Isoform 2 of tRNA (guanine(10)-N2)-m 0.43 12.6 0.0 0.74 11.8 0.0 1.3 1 sp|Q7Z4G4|TRM11_HUMAN tRNA (guanine(10)-N2)-methyltransfer 0.47 12.4 0.0 0.8 11.7 0.0 1.3 1 sp|P46087-2|NOP2_HUMAN Isoform 2 of Putative ribosomal RNA 0.47 12.4 0.0 0.8 11.7 0.0 1.3 1 sp|P46087|NOP2_HUMAN Putative ribosomal RNA methyltransfe 0.5 12.3 0.0 0.85 11.6 0.0 1.3 1 sp|P46087-4|NOP2_HUMAN Isoform 4 of Putative ribosomal RNA 0.78 11.7 0.0 0.89 11.5 0.0 1.2 1 sp|P21964-2|COMT_HUMAN Isoform Soluble of Catechol O-methyl Domain annotation for each sequence (and alignments): >> sp|Q32P41|TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens GN=TRMT5 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.7 0.0 7.1 9.9e+03 2 43 .. 89 131 .. 88 142 .. 0.81 2 ! 209.4 0.0 1.6e-64 2.2e-61 2 186 .. 199 398 .. 198 419 .. 0.92 Alignments for each domain: == domain 1 score: -1.7 bits; conditional E-value: 7.1 EEEEETTEEEEEB-TTSSH.HHHHHHHHHHHHSS-SCEEEE-S CS Met_10 2 kfeiiGdvvilnlreelke.ykkvigevildktkvktvlrkvs 43 f+++ ++ +l++r+e+ + +++++l++ ++ v+++ + sp|Q32P41|TRM5_HUMAN 89 AFKKTVNIPVLKVRKEIVSkLMRSLKRAALQRPGIRRVIEDPE 131 5888889999999999754489999999999999999998655 PP == domain 2 score: 209.4 bits; conditional E-value: 1.6e-64 EEEEETTEEEEEB-TTSSHHHHHHHHHHHHHS.S-SCEEEE-S-SBTTTTB--EEEEEES-.SEEEEEETTEEEEEETTTS---GGGHH CS Met_10 2 kfeiiGdvvilnlreelkeykkvigevildkt.kvktvlrkvsevegefRtfelevlaGsdstetihkEngcrfklDvskvyfssklea 89 +f++iG++++lnlr++ +k++ig+v++dk+ + + ++k ++++ ++R+f++evl G+++++t+++En++++++D+skvy++++l++ sp|Q32P41|TRM5_HUMAN 199 GFSRIGHIAHLNLRDHQLSFKHLIGQVMIDKNpGITSAVNKINNIDNMYRNFQMEVLSGEQNMMTKVRENNYTYEFDFSKVYWNPRLST 287 699************************************************************************************** PP HHHHHHTT--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EE....... CS Met_10 90 ErerlaklveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqlad....... 170 E++r+ +l ++g+v dvfAG+Gpfaip+ak k+ +v+a+dlnPes k+l n klNkv+++vk+++ Dg+++++ + + + sp|Q32P41|TRM5_HUMAN 288 EHSRITELLKPGDVLFDVFAGVGPFAIPVAK--KNCTVFANDLNPESHKWLLYNCKLNKVDQKVKVFNLDGKDFLQgP-VKEelmqllg 373 *******************************..*****************************************9952.3334667*** PP .........EEEE--TTTGGGGHHH CS Met_10 171 .........rvvmnlpksaieFldk 186 +vvmnlp++aieFl + sp|Q32P41|TRM5_HUMAN 374 lskerkpsvHVVMNLPAKAIEFLSA 398 ***********************85 PP >> sp|Q53H54|TYW2_HUMAN tRNA wybutosine-synthesizing protein 2 homolog OS=Homo sapiens GN=TRMT12 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 105.2 0.0 1.3e-32 1.8e-29 47 187 .. 182 321 .. 135 336 .. 0.92 Alignments for each domain: == domain 1 score: 105.2 bits; conditional E-value: 1.3e-32 TTTTB--EEEEEES-.SEEEEEETTEEEEEETTTS---GGGHHHHHHHHTT--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HH CS Met_10 47 gefRtfelevlaGsdstetihkEngcrfklDvskvyfsskleaErerlaklveegevVvdvfAGiGpfaipiakyskakrvlaidlnPe 135 +Rt+ + +l G++ ++h +ng+r+k+Dv++ +fs ++++E+ r+a+l gev vd++AGiG+f++p +++ a +v a + nP+ sp|Q53H54|TYW2_HUMAN 182 DGTRTPAVTLLLGDH-GWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPH 269 458**********99.9************************************************************************ PP HHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TTTGGGGHHHH CS Met_10 136 svkylkeniklNkvekvvkpileDgrevireqladrvvmnlpksaieFldkv 187 +v l++n++ N v+++ + +D+r++ +++adrv+++l+ s++e + sp|Q53H54|TYW2_HUMAN 270 AVVALRNNLEINGVADRCQIHFGDNRKLKLSNIADRVILGLIPSSEEGWPIA 321 *****************************************98887755555 PP >> sp|Q9NXH9-2|TRM1_HUMAN Isoform 2 of tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 26.5 0.0 1.7e-08 2.3e-05 97 198 .. 149 256 .. 137 257 .. 0.78 Alignments for each domain: == domain 1 score: 26.5 bits; conditional E-value: 1.7e-08 T--TT-EEEETT-TTTCCHHHCCHHT.TSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EEEE...EE--T CS Met_10 97 lveegevVvdvfAGiGpfaipiakys.kakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..eqladrv...vmnlp 177 ++eeg V++ +A G +i a + v+a+d ++v ++++n++lN+v++ v+p ++D+r ++ + + +r+ ++ sp|Q9NXH9-2|TRM1_HUMAN 149 ICEEGLHVLEGLAASGLRSIRFALEVpGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhQRVSERFdviDLDPY 235 5677777888888888877777654314578************************************98765344455431045556 PP TTGGGGHHHHHHHEEEEEEEE CS Met_10 178 ksaieFldkvlaalkdggvih 198 s Fld++++a+ +gg+ + sp|Q9NXH9-2|TRM1_HUMAN 236 GSPATFLDAAVQAVSEGGLLC 256 78899**********999987 PP >> sp|Q9NXH9|TRM1_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 26.4 0.0 1.8e-08 2.5e-05 97 198 .. 149 256 .. 137 257 .. 0.78 Alignments for each domain: == domain 1 score: 26.4 bits; conditional E-value: 1.8e-08 T--TT-EEEETT-TTTCCHHHCCHHT.TSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EEEE...EE--TTT CS Met_10 97 lveegevVvdvfAGiGpfaipiakys.kakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..eqladrv...vmnlpks 179 ++eeg V++ +A G +i a + v+a+d ++v ++++n++lN+v++ v+p ++D+r ++ + + +r+ ++ s sp|Q9NXH9|TRM1_HUMAN 149 ICEEGLHVLEGLAASGLRSIRFALEVpGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhQRVSERFdviDLDPYGS 237 5677777888888888877777654314578************************************9876534445543104555678 PP GGGGHHHHHHHEEEEEEEE CS Met_10 180 aieFldkvlaalkdggvih 198 Fld++++a+ +gg+ + sp|Q9NXH9|TRM1_HUMAN 238 PATFLDAAVQAVSEGGLLC 256 899**********999987 PP >> sp|Q96RS0|TGS1_HUMAN Trimethylguanosine synthase OS=Homo sapiens GN=TGS1 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.3 0.0 3.9e-08 5.3e-05 97 163 .. 687 751 .. 669 790 .. 0.85 Alignments for each domain: == domain 1 score: 25.3 bits; conditional E-value: 3.9e-08 T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG- CS Met_10 97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrev 163 + + +vVvd f G+G +i a + rv+aid++P + + ++n + ++++++ i++D + sp|Q96RS0|TGS1_HUMAN 687 QSFKCDVVVDAFCGVGGNTIQFAL--TGMRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLL 751 444679*****************9..9999********************************97555 PP >> tr|K7EQQ8|K7EQQ8_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase (Fragment) OS=Homo sapiens GN=TRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.9 0.0 5.2e-08 7.2e-05 97 171 .. 149 247 .. 136 288 .. 0.70 Alignments for each domain: == domain 1 score: 24.9 bits; conditional E-value: 5.2e-08 T--TT-EEEETT-TTTCCHHHCCHHT.TSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EE.......... CS Met_10 97 lveegevVvdvfAGiGpfaipiakys.kakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..eqlad.......... 170 ++eeg V++ +A G +i a + v+a+d ++v ++++n++lN+v++ v+p ++D+r ++ + + + tr|K7EQQ8|K7EQQ8_HUMAN 149 ICEEGLHVLEGLAASGLRSIRFALEVpGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhQRVSErfdvidldpy 235 5677778888888888888877754314578***********************************998743222334433333344 PP ...........E CS Met_10 171 ...........r 171 + tr|K7EQQ8|K7EQQ8_HUMAN 236 gspatfldaavQ 247 333333333330 PP >> sp|Q7Z2T5-2|TRM1L_HUMAN Isoform 2 of TRMT1-like protein OS=Homo sapiens GN=TRMT1L # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 23.0 0.1 2e-07 0.00028 82 193 .. 95 235 .. 55 286 .. 0.73 Alignments for each domain: == domain 1 score: 23.0 bits; conditional E-value: 2e-07 ---GGGHHHHH....HHHTT--TT-..EEEETT-TTTCCHHHCCHH.TTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-G CS Met_10 82 yfsskleaEre....rlaklveege..vVvdvfAGiGpfaipiaky.skakrvlaidlnPesvkylkeniklNkvekvvkpileDg 160 yf++k + r+ +la+l+ee + +d f G + ak+ ++a++v +dln +sv +++en +lNk++ vv + +++ sp|Q7Z2T5-2|TRM1L_HUMAN 95 YFNPKMKLNRQlifcTLAALAEERKplECLDAFGATGIMGLQWAKHlGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEK 180 6666666666522222333344333223579999999999999987689******************************9988776 PP GG---.TT-EE.....................EEEE--TTTGGGGHHHHHHHEEE CS Met_10 161 revir.eqlad.....................rvvmnlpksaieFldkvlaalkd 193 + i e + + ++ +++++ld++++ +++ sp|Q7Z2T5-2|TRM1L_HUMAN 181 SDDILeEGEKNlgnikvtkmdanvlmhlrsfdFIHLDPFGTSVNYLDSAFRNIRN 235 5544324444466677777777555555555322334444555555555555555 PP >> sp|Q7Z2T5|TRM1L_HUMAN TRMT1-like protein OS=Homo sapiens GN=TRMT1L PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.0 0.1 7.8e-07 0.0011 104 171 .. 279 368 .. 212 397 .. 0.68 Alignments for each domain: == domain 1 score: 21.0 bits; conditional E-value: 7.8e-07 EEETT-TTTCCHHHCCHH.TTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EE................... CS Met_10 104 VvdvfAGiGpfaipiaky.skakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqlad................... 170 +d f G + ak+ ++a++v +dln +sv +++en +lNk++ vv + +++ + i e + sp|Q7Z2T5|TRM1L_HUMAN 279 CLDAFGATGIMGLQWAKHlGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEKSDDILeEGEKNlgnikvtkmdanvlmhlrs 366 579999999999999987689******************************9988776554432433335566666666655555555 PP .E CS Met_10 171 .r 171 sp|Q7Z2T5|TRM1L_HUMAN 367 fD 368 52 PP >> sp|Q8IXQ9|MET20_HUMAN Methyltransferase-like protein 20 OS=Homo sapiens GN=METTL20 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.7 0.0 5e-07 0.00069 82 151 .. 96 165 .. 92 217 .. 0.81 Alignments for each domain: == domain 1 score: 21.7 bits; conditional E-value: 5e-07 ---GGGHHHHHHHHTT.--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TT CS Met_10 82 yfsskleaErerlakl.veegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvek 151 y+ + + r l + v g+ V+d+ G G ai+++ s a+r+la+d++P + ++ n +lN+++ sp|Q8IXQ9|MET20_HUMAN 96 YWPGGQALSRYLLDNPdVVRGKSVLDLGSGCGATAIAAKM-SGASRILANDIDPIAGMAITLNCELNRLNP 165 5555555555555555577899**************9875.99999*********************9975 PP >> tr|E9PNR9|E9PNR9_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.8 0.1 4.4e-07 0.00061 100 178 .. 42 119 .. 26 138 .. 0.81 Alignments for each domain: == domain 1 score: 21.8 bits; conditional E-value: 4.4e-07 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--TT CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlpk 178 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + tr|E9PNR9|E9PNR9_HUMAN 42 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWMG 119 578*****************9.88999*****98665.8999**********************8867778877744433 PP >> sp|Q96LA8|ANM6_HUMAN Protein arginine N-methyltransferase 6 OS=Homo sapiens GN=PRMT6 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.6 0.0 5.1e-07 0.00071 100 176 .. 82 156 .. 53 203 .. 0.87 Alignments for each domain: == domain 1 score: 21.6 bits; conditional E-value: 5.1e-07 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE-- CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnl 176 g++V+dv AG G ++i +a+ + a+rv+a++ + + +e ++ N +e++v+++ + +++v ++++d +v + sp|Q96LA8|ANM6_HUMAN 82 RGKTVLDVGAGTGILSIFCAQ-AGARRVYAVEAS-AIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEW 156 699*****************8.89999*****86.5678899***********************999999998433 PP >> tr|H7C2H9|H7C2H9_HUMAN Protein arginine N-methyltransferase 2 (Fragment) OS=Homo sapiens GN=PRMT2 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.1 0.0 7.7e-07 0.0011 100 184 .. 77 160 .. 57 169 .. 0.85 Alignments for each domain: == domain 1 score: 21.1 bits; conditional E-value: 7.7e-07 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TTTGGGGH CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpksaieFl 184 ++v++dv G G ++ +a+y++++ v+a++ + + + + N +++++++++ +++v+ ++++d +v + + ++ l tr|H7C2H9|H7C2H9_HUMAN 77 TDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMA-QHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLLL 160 56899***************************98555.667889999*********************99999988887776555 PP >> tr|E9PQ98|E9PQ98_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.0 0.0 8.3e-07 0.0011 100 178 .. 42 119 .. 26 139 .. 0.81 Alignments for each domain: == domain 1 score: 21.0 bits; conditional E-value: 8.3e-07 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--TT CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlpk 178 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + tr|E9PQ98|E9PQ98_HUMAN 42 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWMG 119 578*****************9.88999*****98665.8999**********************8867778877744333 PP >> tr|E9PIX6|E9PIX6_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 20.9 0.0 8.6e-07 0.0012 100 178 .. 42 119 .. 26 139 .. 0.81 Alignments for each domain: == domain 1 score: 20.9 bits; conditional E-value: 8.6e-07 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--TT CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlpk 178 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + tr|E9PIX6|E9PIX6_HUMAN 42 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWMG 119 578*****************9.88999*****98665.8999**********************8867778877744333 PP >> sp|Q9NR22-2|ANM8_HUMAN Isoform 2 of Protein arginine N-methyltransferase 8 OS=Homo sapiens GN=PRMT8 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 20.3 0.0 1.3e-06 0.0018 97 177 .. 99 178 .. 86 199 .. 0.81 Alignments for each domain: == domain 1 score: 20.3 bits; conditional E-value: 1.3e-06 T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--T CS Met_10 97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlp 177 v +++vV+dv G G +++ +ak + ak+v++i+ s y ++ ik N+++++++ +++ ++ev +++d ++ + + sp|Q9NR22-2|ANM8_HUMAN 99 HVFKDKVVLDVGSGTGILSMFAAK-AGAKKVFGIECSSIS-DYSEKIIKANHLDNIITIFKGKVEEVELpVEKVDIIISEWM 178 466789*****************9.88999*****98665.8*************************886777887774433 PP >> sp|Q9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 8 OS=Homo sapiens GN=PRMT8 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 20.3 0.0 1.4e-06 0.0019 98 177 .. 109 187 .. 95 208 .. 0.81 Alignments for each domain: == domain 1 score: 20.3 bits; conditional E-value: 1.4e-06 --TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--T CS Met_10 98 veegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlp 177 v +++vV+dv G G +++ +ak + ak+v++i+ s y ++ ik N+++++++ +++ ++ev +++d ++ + + sp|Q9NR22|ANM8_HUMAN 109 VFKDKVVLDVGSGTGILSMFAAK-AGAKKVFGIECSSIS-DYSEKIIKANHLDNIITIFKGKVEEVELpVEKVDIIISEWM 187 66789*****************9.88999*****98665.8*************************876777787774433 PP >> sp|O60678-2|ANM3_HUMAN Isoform 2 of Protein arginine N-methyltransferase 3 OS=Homo sapiens GN=PRMT3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.3 0.0 2.6e-06 0.0036 100 176 .. 193 271 .. 176 293 .. 0.81 Alignments for each domain: == domain 1 score: 19.3 bits; conditional E-value: 2.6e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEE...E-- CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvv...mnl 176 +++vV+dv G G +++ +ak + ak+vl++d ++ + i+lNk+e++++ i++ +ev +++d ++ m++ sp|O60678-2|ANM3_HUMAN 193 KDKVVLDVGCGTGILSMFAAK-AGAKKVLGVDQSEILYQAMD-IIRLNKLEDTITLIKGKIEEVHLpVEKVDVIIsewMGY 271 568*****************9.88999*****9988888775.7*******************987667777766444444 PP >> tr|H0YDE4|H0YDE4_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 20.4 0.1 1.2e-06 0.0017 100 178 .. 98 175 .. 83 194 .. 0.81 Alignments for each domain: == domain 1 score: 20.4 bits; conditional E-value: 1.2e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--TT CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlpk 178 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + tr|H0YDE4|H0YDE4_HUMAN 98 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWMG 175 568*****************9.88999*****98665.8999**********************8867778877744333 PP >> tr|B7U630|B7U630_HUMAN PRMT2 alpha variant OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 20.2 0.0 1.4e-06 0.002 100 183 .. 137 219 .. 119 240 .. 0.84 Alignments for each domain: == domain 1 score: 20.2 bits; conditional E-value: 1.4e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TTTGGGG CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpksaieF 183 ++v++dv G G ++ +a+y++++ v+a++ + + + + N +++++++++ +++v+ ++++d +v + + ++ F tr|B7U630|B7U630_HUMAN 137 TDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMA-QHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLF 219 56899***************************98555.667889999************************9998888777544 PP >> sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 3 OS=Homo sapiens GN=PRMT3 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.1 0.0 3.2e-06 0.0044 100 176 .. 255 333 .. 238 355 .. 0.82 Alignments for each domain: == domain 1 score: 19.1 bits; conditional E-value: 3.2e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEE...E-- CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvv...mnl 176 +++vV+dv G G +++ +ak + ak+vl++d ++ + i+lNk+e++++ i++ +ev +++d ++ m++ sp|O60678|ANM3_HUMAN 255 KDKVVLDVGCGTGILSMFAAK-AGAKKVLGVDQSEILYQAMD-IIRLNKLEDTITLIKGKIEEVHLpVEKVDVIIsewMGY 333 568*****************9.88999*****9988888775.7*******************987667777766444444 PP >> tr|E9PKG1|E9PKG1_HUMAN Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.5 0.1 2.4e-06 0.0033 100 177 .. 42 118 .. 28 138 .. 0.81 Alignments for each domain: == domain 1 score: 19.5 bits; conditional E-value: 2.4e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--T CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlp 177 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + tr|E9PKG1|E9PKG1_HUMAN 42 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWM 118 568*****************9.88999*****98665.8999**********************886777887774433 PP >> sp|Q99873-3|ANM1_HUMAN Isoform 3 of Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.3 0.1 2.6e-06 0.0036 100 177 .. 60 136 .. 46 156 .. 0.81 Alignments for each domain: == domain 1 score: 19.3 bits; conditional E-value: 2.6e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--T CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlp 177 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + sp|Q99873-3|ANM1_HUMAN 60 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWM 136 568*****************9.88999*****98665.8999**********************886777787774433 PP >> sp|Q99873-2|ANM1_HUMAN Isoform 2 of Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.3 0.1 2.7e-06 0.0037 100 177 .. 64 140 .. 50 160 .. 0.81 Alignments for each domain: == domain 1 score: 19.3 bits; conditional E-value: 2.7e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--T CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlp 177 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + sp|Q99873-2|ANM1_HUMAN 64 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWM 140 568*****************9.88999*****98665.8999**********************886777787774433 PP >> tr|B7U632|B7U632_HUMAN PRMT2 gamma variant OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.5 0.0 2.4e-06 0.0033 100 177 .. 137 213 .. 118 224 .. 0.85 Alignments for each domain: == domain 1 score: 19.5 bits; conditional E-value: 2.4e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--T CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlp 177 ++v++dv G G ++ +a+y++++ v+a++ + + + + N +++++++++ +++v+ ++++d +v + + tr|B7U632|B7U632_HUMAN 137 TDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMA-QHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWM 213 56899***************************98555.667889999******************9999998886655 PP >> sp|Q99873-4|ANM1_HUMAN Isoform 4 of Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.3 0.1 2.8e-06 0.0038 100 177 .. 70 146 .. 56 166 .. 0.81 Alignments for each domain: == domain 1 score: 19.3 bits; conditional E-value: 2.8e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--T CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlp 177 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + sp|Q99873-4|ANM1_HUMAN 70 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWM 146 568*****************9.88999*****98665.8999**********************886777787774433 PP >> sp|Q99873|ANM1_HUMAN Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.2 0.1 2.9e-06 0.004 100 177 .. 78 154 .. 64 174 .. 0.81 Alignments for each domain: == domain 1 score: 19.2 bits; conditional E-value: 2.9e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--T CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlp 177 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + sp|Q99873|ANM1_HUMAN 78 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWM 154 568*****************9.88999*****98665.8999**********************886777787774433 PP >> sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.1 0.0 3e-06 0.0042 97 152 .. 429 482 .. 418 515 .. 0.88 Alignments for each domain: == domain 1 score: 19.1 bits; conditional E-value: 3e-06 T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTC CS Met_10 97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekv 152 + + g +V+dv G G +++a+ k krv++++l Pe+v+ + n + N++++v sp|Q8IZ69-2|TRM2A_HUMAN 429 QLDAGSMVLDVCCGTGTIGLALAR--KVKRVIGVELCPEAVEDARVNAQDNELSNV 482 567899*****************9..*************************99875 PP >> tr|H7C2I1|H7C2I1_HUMAN Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.1 0.1 3e-06 0.0042 100 177 .. 88 164 .. 74 184 .. 0.81 Alignments for each domain: == domain 1 score: 19.1 bits; conditional E-value: 3e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--T CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlp 177 +++vV+dv G G + + +ak + a++v++i+ s y + +k Nk+++vv+ i++ ++ev +++d ++ + + tr|H7C2I1|H7C2I1_HUMAN 88 KDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEVELpVEKVDIIISEWM 164 568*****************9.88999*****98665.8999**********************886777787774433 PP >> tr|D6RCL3|D6RCL3_HUMAN Probable dimethyladenosine transferase OS=Homo sapiens GN=DIMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.4 0.0 2.4e-06 0.0033 98 179 .. 54 132 .. 46 144 .. 0.88 Alignments for each domain: == domain 1 score: 19.4 bits; conditional E-value: 2.4e-06 --TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TTT CS Met_10 98 veegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpks 179 ++ +vV++v G G ++ + kak+v+a +l+P+ v l++ ++ v+++++++ +D+ + ++d v nlp++ tr|D6RCL3|D6RCL3_HUMAN 54 LRPTDVVLEVGPGTGNMTVKLLE--KAKKVVACELDPRLVAELHKRVQGTPVASKLQVLVGDVLKTD-LPFFDTCVANLPYQ 132 6789***************9998..*************************************98875.66788888888865 PP >> tr|B7U631|B7U631_HUMAN PRMT2 beta variant OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.2 0.0 2.8e-06 0.0038 100 180 .. 137 216 .. 119 233 .. 0.84 Alignments for each domain: == domain 1 score: 19.2 bits; conditional E-value: 2.8e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TTTG CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpksa 180 ++v++dv G G ++ +a+y++++ v+a++ + + + + N +++++++++ +++v+ ++++d +v + + ++ tr|B7U631|B7U631_HUMAN 137 TDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMA-QHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTC 216 56899***************************98555.667889999*******************999998887766655 PP >> sp|P55345|ANM2_HUMAN Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.1 0.0 3.1e-06 0.0043 100 182 .. 137 218 .. 119 240 .. 0.84 Alignments for each domain: == domain 1 score: 19.1 bits; conditional E-value: 3.1e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TTTGGG CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpksaie 182 ++v++dv G G ++ +a+y++++ v+a++ + + + + N +++++++++ +++v+ ++++d +v + + ++ sp|P55345|ANM2_HUMAN 137 TDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMA-QHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLL 218 56899***************************98555.667889999***********************9999888877754 PP >> sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.9 0.0 3.5e-06 0.0049 97 152 .. 429 482 .. 418 514 .. 0.88 Alignments for each domain: == domain 1 score: 18.9 bits; conditional E-value: 3.5e-06 T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTC CS Met_10 97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekv 152 + + g +V+dv G G +++a+ k krv++++l Pe+v+ + n + N++++v sp|Q8IZ69|TRM2A_HUMAN 429 QLDAGSMVLDVCCGTGTIGLALAR--KVKRVIGVELCPEAVEDARVNAQDNELSNV 482 567899*****************9..*************************99875 PP >> tr|A8MXR3|A8MXR3_HUMAN Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.1 0.0 3.2e-06 0.0044 100 177 .. 137 213 .. 119 224 .. 0.86 Alignments for each domain: == domain 1 score: 19.1 bits; conditional E-value: 3.2e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--T CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlp 177 ++v++dv G G ++ +a+y++++ v+a++ + + + + N +++++++++ +++v+ ++++d +v + + tr|A8MXR3|A8MXR3_HUMAN 137 TDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMA-QHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWM 213 56899***************************98555.667889999******************9999998876655 PP >> sp|P55345-2|ANM2_HUMAN Isoform 2 of Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.1 0.0 3e-06 0.0041 100 177 .. 137 213 .. 119 241 .. 0.85 Alignments for each domain: == domain 1 score: 19.1 bits; conditional E-value: 3e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--T CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlp 177 ++v++dv G G ++ +a+y++++ v+a++ + + + + N +++++++++ +++v+ ++++d +v + + sp|P55345-2|ANM2_HUMAN 137 TDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMA-QHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWM 213 56899***************************98555.667889999******************9999997775544 PP >> sp|P55345-3|ANM2_HUMAN Isoform 3 of Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.9 0.0 3.5e-06 0.0048 100 180 .. 137 216 .. 119 237 .. 0.84 Alignments for each domain: == domain 1 score: 18.9 bits; conditional E-value: 3.5e-06 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TTTG CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpksa 180 ++v++dv G G ++ +a+y++++ v+a++ + + + + N +++++++++ +++v+ ++++d +v + + ++ sp|P55345-3|ANM2_HUMAN 137 TDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMA-QHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTC 216 56899***************************98555.667889999*******************999998887766665 PP >> sp|Q9UNQ2|DIM1_HUMAN Probable dimethyladenosine transferase OS=Homo sapiens GN=DIMT1 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 17.2 0.0 1.2e-05 0.016 98 179 .. 54 132 .. 46 143 .. 0.88 Alignments for each domain: == domain 1 score: 17.2 bits; conditional E-value: 1.2e-05 --TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TTT CS Met_10 98 veegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpks 179 ++ +vV++v G G ++ + kak+v+a +l+P+ v l++ ++ v+++++++ +D+ + ++d v nlp++ sp|Q9UNQ2|DIM1_HUMAN 54 LRPTDVVLEVGPGTGNMTVKLLE--KAKKVVACELDPRLVAELHKRVQGTPVASKLQVLVGDVLKTD-LPFFDTCVANLPYQ 132 6789***************9998..*************************************98775.66788888888765 PP >> tr|B3KU92|B3KU92_HUMAN Putative protein arginine N-methyltransferase 10 OS=Homo sapiens GN=LOC90826 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.3 0.0 2.2e-05 0.031 102 164 .. 66 127 .. 42 147 .. 0.83 Alignments for each domain: == domain 1 score: 16.3 bits; conditional E-value: 2.2e-05 -EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG-- CS Met_10 102 evVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevi 164 + V+d+ AG G +++ ++k + a+ v+a +l + +++ ++ ++ Nk+e +k + + + ++ tr|B3KU92|B3KU92_HUMAN 66 KSVLDIGAGTGILSMFAKK-AGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIE 127 579************9999.88889*************************9998877666664 PP >> sp|Q6P2P2|ANM10_HUMAN Putative protein arginine N-methyltransferase 10 OS=Homo sapiens GN=PRMT10 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.0 0.0 2.7e-05 0.038 102 164 .. 179 240 .. 155 259 .. 0.83 Alignments for each domain: == domain 1 score: 16.0 bits; conditional E-value: 2.7e-05 -EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG-- CS Met_10 102 evVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevi 164 + V+d+ AG G +++ ++k + a+ v+a +l + +++ ++ ++ Nk+e +k + + + ++ sp|Q6P2P2|ANM10_HUMAN 179 KSVLDIGAGTGILSMFAKK-AGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIE 240 579************9999.88889*************************9998877666664 PP >> tr|A8MTP3|A8MTP3_HUMAN Protein arginine N-methyltransferase 5 OS=Homo sapiens GN=PRMT5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.3 0.0 2.3e-05 0.032 102 178 .. 188 267 .. 164 341 .. 0.76 Alignments for each domain: == domain 1 score: 16.3 bits; conditional E-value: 2.3e-05 -EEEETT-TTTCC...HHHCCHHTTSS.EEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TT CS Met_10 102 evVvdvfAGiGpf...aipiakyskak.rvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpk 178 +v + + AG Gp+ ++ +ak ++ + +++a+++nP++v l en + + + v+++ +D re + +++ad +v +l tr|A8MTP3|A8MTP3_HUMAN 188 QVLMVLGAGRGPLvnaSLRAAKQADRRiKLYAVEKNPNAVVTL-ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLG 267 344455577787644467788876554269**********887.79***************************77766553 PP >> tr|B4DV00|B4DV00_HUMAN Protein arginine N-methyltransferase 5 OS=Homo sapiens GN=PRMT5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.9 0.0 2.9e-05 0.04 102 178 .. 253 332 .. 230 406 .. 0.76 Alignments for each domain: == domain 1 score: 15.9 bits; conditional E-value: 2.9e-05 -EEEETT-TTTCC...HHHCCHHTTSS.EEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TT CS Met_10 102 evVvdvfAGiGpf...aipiakyskak.rvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpk 178 +v + + AG Gp+ ++ +ak ++ + +++a+++nP++v l en + + + v+++ +D re + +++ad +v +l tr|B4DV00|B4DV00_HUMAN 253 QVLMVLGAGRGPLvnaSLRAAKQADRRiKLYAVEKNPNAVVTL-ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLG 332 344455577787644467788876554269**********887.79***************************77766553 PP >> tr|K7EQA8|K7EQA8_HUMAN Histone-arginine methyltransferase CARM1 (Fragment) OS=Homo sapiens GN=CARM1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.7 0.0 3.5e-05 0.048 101 174 .. 144 308 .. 128 329 .. 0.70 Alignments for each domain: == domain 1 score: 15.7 bits; conditional E-value: 3.5e-05 T-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EE................. CS Met_10 101 gevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqlad................. 170 +++V+dv G G ++ +a+ + a++++a++ + + + +k N++ +++ +i + ++ev ++++d tr|K7EQA8|K7EQA8_HUMAN 144 DKIVLDVGCGSGILSFFAAQ-AGARKIYAVEASTMA-QHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDiiisepmgymlfnerml 228 679****************8.89999*****98776.568999***************************66666666666666555 PP ............................................................................EEEE CS Met_10 171 ............................................................................rvvm 174 r++m tr|K7EQA8|K7EQA8_HUMAN 229 esylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdiRILM 308 55555555555555555555555555555555555555555555555555555555555555555555555555555555 PP >> tr|B4DX49|B4DX49_HUMAN Protein arginine N-methyltransferase 5 OS=Homo sapiens GN=PRMT5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.7 0.0 3.4e-05 0.046 102 178 .. 298 377 .. 276 451 .. 0.76 Alignments for each domain: == domain 1 score: 15.7 bits; conditional E-value: 3.4e-05 -EEEETT-TTTCC...HHHCCHHTTSS.EEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TT CS Met_10 102 evVvdvfAGiGpf...aipiakyskak.rvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpk 178 +v + + AG Gp+ ++ +ak ++ + +++a+++nP++v l en + + + v+++ +D re + +++ad +v +l tr|B4DX49|B4DX49_HUMAN 298 QVLMVLGAGRGPLvnaSLRAAKQADRRiKLYAVEKNPNAVVTL-ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLG 377 344455577787644467788876554269**********887.79***************************77766553 PP >> tr|G3V5W5|G3V5W5_HUMAN Protein arginine N-methyltransferase 5 OS=Homo sapiens GN=PRMT5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.6 0.0 3.5e-05 0.049 102 178 .. 315 394 .. 293 468 .. 0.76 Alignments for each domain: == domain 1 score: 15.6 bits; conditional E-value: 3.5e-05 -EEEETT-TTTCC...HHHCCHHTTSS.EEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TT CS Met_10 102 evVvdvfAGiGpf...aipiakyskak.rvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpk 178 +v + + AG Gp+ ++ +ak ++ + +++a+++nP++v l en + + + v+++ +D re + +++ad +v +l tr|G3V5W5|G3V5W5_HUMAN 315 QVLMVLGAGRGPLvnaSLRAAKQADRRiKLYAVEKNPNAVVTL-ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLG 394 344455577787644467788876554269**********887.79***************************77766553 PP >> sp|Q86X55-2|CARM1_HUMAN Isoform 2 of Histone-arginine methyltransferase CARM1 OS=Homo sapiens GN=CARM1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.2 0.0 4.8e-05 0.066 101 171 .. 185 346 .. 170 369 .. 0.69 Alignments for each domain: == domain 1 score: 15.2 bits; conditional E-value: 4.8e-05 T-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EE................ CS Met_10 101 gevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqlad................ 170 +++V+dv G G ++ +a+ + a++++a++ + + + +k N++ +++ +i + ++ev ++++d sp|Q86X55-2|CARM1_HUMAN 185 DKIVLDVGCGSGILSFFAAQ-AGARKIYAVEASTMA-QHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDiiisepmgymlfnerm 268 679****************8.89999*****98776.568999***************************6666666666666655 PP .............................................................................E CS Met_10 171 .............................................................................r 171 r sp|Q86X55-2|CARM1_HUMAN 269 lesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdiR 346 555555555555555555555555555555555555555555555555555555555555555555555555555555 PP >> sp|O14744-2|ANM5_HUMAN Isoform 2 of Protein arginine N-methyltransferase 5 OS=Homo sapiens GN=PRMT5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.5 0.0 3.9e-05 0.054 102 178 .. 342 421 .. 320 494 .. 0.77 Alignments for each domain: == domain 1 score: 15.5 bits; conditional E-value: 3.9e-05 -EEEETT-TTTCC...HHHCCHHTTSS.EEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TT CS Met_10 102 evVvdvfAGiGpf...aipiakyskak.rvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpk 178 +v + + AG Gp+ ++ +ak ++ + +++a+++nP++v l en + + + v+++ +D re + +++ad +v +l sp|O14744-2|ANM5_HUMAN 342 QVLMVLGAGRGPLvnaSLRAAKQADRRiKLYAVEKNPNAVVTL-ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLG 421 344455577787644467788876554269**********887.79***************************77766554 PP >> sp|O14744|ANM5_HUMAN Protein arginine N-methyltransferase 5 OS=Homo sapiens GN=PRMT5 PE=1 SV=4 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.4 0.0 4.1e-05 0.056 102 178 .. 359 438 .. 337 511 .. 0.77 Alignments for each domain: == domain 1 score: 15.4 bits; conditional E-value: 4.1e-05 -EEEETT-TTTCC...HHHCCHHTTSS.EEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE--TT CS Met_10 102 evVvdvfAGiGpf...aipiakyskak.rvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvmnlpk 178 +v + + AG Gp+ ++ +ak ++ + +++a+++nP++v l en + + + v+++ +D re + +++ad +v +l sp|O14744|ANM5_HUMAN 359 QVLMVLGAGRGPLvnaSLRAAKQADRRiKLYAVEKNPNAVVTL-ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLG 438 344455577787644467788876554269**********887.79***************************77766554 PP >> sp|Q86X55-1|CARM1_HUMAN Isoform 1 of Histone-arginine methyltransferase CARM1 OS=Homo sapiens GN=CARM1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.2 0.0 0.0001 0.14 101 171 .. 185 346 .. 170 374 .. 0.69 Alignments for each domain: == domain 1 score: 14.2 bits; conditional E-value: 0.0001 T-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EE................ CS Met_10 101 gevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqlad................ 170 +++V+dv G G ++ +a+ + a++++a++ + + + +k N++ +++ +i + ++ev ++++d sp|Q86X55-1|CARM1_HUMAN 185 DKIVLDVGCGSGILSFFAAQ-AGARKIYAVEASTMA-QHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDiiisepmgymlfnerm 268 679****************8.89999*****98776.568999***************************6666666666666655 PP .............................................................................E CS Met_10 171 .............................................................................r 171 r sp|Q86X55-1|CARM1_HUMAN 269 lesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdiR 346 555555555555555555555555555555555555555555555555555555555555555555555555555555 PP >> sp|Q86X55|CARM1_HUMAN Histone-arginine methyltransferase CARM1 OS=Homo sapiens GN=CARM1 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.1 0.0 0.00011 0.15 101 171 .. 185 346 .. 170 374 .. 0.69 Alignments for each domain: == domain 1 score: 14.1 bits; conditional E-value: 0.00011 T-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EE.................. CS Met_10 101 gevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqlad.................. 170 +++V+dv G G ++ +a+ + a++++a++ + + + +k N++ +++ +i + ++ev ++++d sp|Q86X55|CARM1_HUMAN 185 DKIVLDVGCGSGILSFFAAQ-AGARKIYAVEASTMA-QHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDiiisepmgymlfnermle 270 679****************8.89999*****98776.568999***************************666666666666665555 PP ...........................................................................E CS Met_10 171 ...........................................................................r 171 r sp|Q86X55|CARM1_HUMAN 271 sylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdiR 346 5555555555555555555555555555555555555555555555555555555555555555555555555555 PP >> tr|H0Y768|H0Y768_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog (Fragment) OS=Homo sapiens GN=TRMT11 PE=4 SV= # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.1 0.0 0.0001 0.14 97 148 .. 11 60 .. 5 64 .. 0.90 Alignments for each domain: == domain 1 score: 14.1 bits; conditional E-value: 0.0001 T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT CS Met_10 97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNk 148 +v+e+++V d f G G + i++a+ + v++ d++ ++v+ l ++ + N+ tr|H0Y768|H0Y768_HUMAN 11 KVKENDIVFDPFVGTGGLLIACAH--FGAYVYGTDIDYNTVHGLGKATRKNQ 60 599********************9..55779***********9999999886 PP >> tr|B8ZZE3|B8ZZE3_HUMAN Methyltransferase like 5, isoform CRA_b OS=Homo sapiens GN=METTL5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.7 0.0 0.00014 0.19 100 182 .. 51 133 .. 44 167 .. 0.84 Alignments for each domain: == domain 1 score: 13.7 bits; conditional E-value: 0.00014 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EEEEEE--TTTGGG CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..eqladrvvmnlpksaie 182 e++vV d+ G G ++i a ++ + ++ d++ ++ + +++n + ++ + + ++ D+ + + ++ +d v+mn p + + tr|B8ZZE3|B8ZZE3_HUMAN 51 ENKVVADLGCGCGVLSIGTAMLGAG-LCVGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSNrmSKSFDTVIMNPPFGTKN 133 799*****************97765.588*****************999987.568999999888778999*******9866554 PP >> sp|Q9NRN9|METL5_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.6 0.0 0.00015 0.21 100 182 .. 51 133 .. 43 165 .. 0.84 Alignments for each domain: == domain 1 score: 13.6 bits; conditional E-value: 0.00015 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EEEEEE--TTTGGG CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..eqladrvvmnlpksaie 182 e++vV d+ G G ++i a ++ + ++ d++ ++ + +++n + ++ + + ++ D+ + + ++ +d v+mn p + + sp|Q9NRN9|METL5_HUMAN 51 ENKVVADLGCGCGVLSIGTAMLGAG-LCVGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSNrmSKSFDTVIMNPPFGTKN 133 799*****************97765.588*****************999987.568999999888778999*******9866554 PP >> tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.7 0.0 0.00014 0.2 100 180 .. 51 131 .. 43 154 .. 0.87 Alignments for each domain: == domain 1 score: 13.7 bits; conditional E-value: 0.00014 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EEEEEE--TTTG CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..eqladrvvmnlpksa 180 e++vV d+ G G ++i a ++ + ++ d++ ++ + +++n + ++ + + ++ D+ + + ++ +d v+mn p + tr|E7EMN2|E7EMN2_HUMAN 51 ENKVVADLGCGCGVLSIGTAMLGAG-LCVGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSNrmSKSFDTVIMNPPFGT 131 799*****************97765.588*****************999987.568999999888778999*******88655 PP >> tr|B8ZZC8|B8ZZC8_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.7 0.0 0.00028 0.39 100 181 .. 51 132 .. 46 153 .. 0.84 Alignments for each domain: == domain 1 score: 12.7 bits; conditional E-value: 0.00028 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EEEEEE--TTTGG CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..eqladrvvmnlpksai 181 e++vV d+ G G ++i a ++ + ++ d++ ++ + +++n + ++ + + ++ D+ + + ++ +d v+mn p + tr|B8ZZC8|B8ZZC8_HUMAN 51 ENKVVADLGCGCGVLSIGTAMLGAG-LCVGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSNrmSKSFDTVIMNPPFGTK 132 799*****************97765.588*****************999987.568999999888778999*******986655 PP >> tr|H3BNC0|H3BNC0_HUMAN Protein arginine N-methyltransferase 7 OS=Homo sapiens GN=PRMT7 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 5.3 0.0 0.053 73 100 164 .. 64 127 .. 44 170 .. 0.83 2 ? 5.9 0.0 0.035 49 120 164 .. 419 463 .. 395 528 .. 0.80 Alignments for each domain: == domain 1 score: 5.3 bits; conditional E-value: 0.053 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG-- CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevi 164 + +V+d+ G G +++ + + a + +ai++ + ++ N ++++k+i++ + ev+ tr|H3BNC0|H3BNC0_HUMAN 64 QKALVLDIGTGTGLLSMMAVT-AGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVT 127 44589***********98775.88999*****85444555667899************9999987 PP == domain 2 score: 5.9 bits; conditional E-value: 0.035 HHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG-- CS Met_10 120 kyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevi 164 ++ ++v++++ +s k+l++ k N++e++++ i++ + ++ tr|H3BNC0|H3BNC0_HUMAN 419 HHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLT 463 4455567***************************88876555554 PP >> sp|Q9NVM4-4|ANM7_HUMAN Isoform 4 of Protein arginine N-methyltransferase 7 OS=Homo sapiens GN=PRMT7 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 5.3 0.0 0.053 73 100 164 .. 64 127 .. 44 170 .. 0.83 2 ? 5.9 0.0 0.035 49 120 164 .. 419 463 .. 395 528 .. 0.80 Alignments for each domain: == domain 1 score: 5.3 bits; conditional E-value: 0.053 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG-- CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevi 164 + +V+d+ G G +++ + + a + +ai++ + ++ N ++++k+i++ + ev+ sp|Q9NVM4-4|ANM7_HUMAN 64 QKALVLDIGTGTGLLSMMAVT-AGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVT 127 44589***********98775.88999*****85444555667899************9999987 PP == domain 2 score: 5.9 bits; conditional E-value: 0.035 HHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG-- CS Met_10 120 kyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevi 164 ++ ++v++++ +s k+l++ k N++e++++ i++ + ++ sp|Q9NVM4-4|ANM7_HUMAN 419 HHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLT 463 4455567***************************88876555554 PP >> tr|F2Z2Q4|F2Z2Q4_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.4 0.0 0.00034 0.48 97 148 .. 212 261 .. 206 264 .. 0.89 Alignments for each domain: == domain 1 score: 12.4 bits; conditional E-value: 0.00034 T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT CS Met_10 97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNk 148 +v+e+++V d f G G + i++a+ + v++ d++ ++v+ l ++ + N+ tr|F2Z2Q4|F2Z2Q4_HUMAN 212 KVKENDIVFDPFVGTGGLLIACAH--FGAYVYGTDIDYNTVHGLGKATRKNQ 261 599********************9..55779**********99999999886 PP >> sp|P46087-3|NOP2_HUMAN Isoform 3 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.2 0.0 0.0004 0.55 99 190 .. 379 473 .. 372 485 .. 0.79 Alignments for each domain: == domain 1 score: 12.2 bits; conditional E-value: 0.0004 -TT-EEEETT.-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--TTTGGGG CS Met_10 99 eegevVvdvf.AGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlpksaieF 183 +e e+++d+ A G+ + + + + +la+d n e k + n+++ v +++ Dgr++ + +drv++++p s + sp|P46087-3|NOP2_HUMAN 379 QEHERILDMCcAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTI-ISHYDGRQFPKvVGGFDRVLLDAPCSGTGV 464 7788999997244455555555556778899*************************.5578*****998899*******99988777 PP HHH..HHHH CS Met_10 184 ldk..vlaa 190 + k ++++ sp|P46087-3|NOP2_HUMAN 465 ISKdpAVKT 473 776555554 PP >> sp|Q9NVM4|ANM7_HUMAN Protein arginine N-methyltransferase 7 OS=Homo sapiens GN=PRMT7 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 4.9 0.0 0.072 99 100 164 .. 64 127 .. 44 168 .. 0.83 2 ? 5.6 0.0 0.042 58 120 165 .. 419 464 .. 395 555 .. 0.81 Alignments for each domain: == domain 1 score: 4.9 bits; conditional E-value: 0.072 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG-- CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevi 164 + +V+d+ G G +++ + + a + +ai++ + ++ N ++++k+i++ + ev+ sp|Q9NVM4|ANM7_HUMAN 64 QKALVLDIGTGTGLLSMMAVT-AGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVT 127 44589***********98775.88999*****85444555667899************9999987 PP == domain 2 score: 5.6 bits; conditional E-value: 0.042 HHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG--- CS Met_10 120 kyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir 165 ++ ++v++++ +s k+l++ k N++e++++ i++ + +++ sp|Q9NVM4|ANM7_HUMAN 419 HHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTN 464 4455567***************************888765555544 PP >> sp|Q7Z4G4-2|TRM11_HUMAN Isoform 2 of tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.8 0.0 0.00052 0.73 97 148 .. 212 261 .. 206 264 .. 0.89 Alignments for each domain: == domain 1 score: 11.8 bits; conditional E-value: 0.00052 T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT CS Met_10 97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNk 148 +v+e+++V d f G G + i++a+ + v++ d++ ++v+ l ++ + N+ sp|Q7Z4G4-2|TRM11_HUMAN 212 KVKENDIVFDPFVGTGGLLIACAH--FGAYVYGTDIDYNTVHGLGKATRKNQ 261 599********************9..55779**********99999999886 PP >> sp|Q7Z4G4|TRM11_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.8 0.0 0.00053 0.74 97 148 .. 212 261 .. 206 264 .. 0.89 Alignments for each domain: == domain 1 score: 11.8 bits; conditional E-value: 0.00053 T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT CS Met_10 97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNk 148 +v+e+++V d f G G + i++a+ + v++ d++ ++v+ l ++ + N+ sp|Q7Z4G4|TRM11_HUMAN 212 KVKENDIVFDPFVGTGGLLIACAH--FGAYVYGTDIDYNTVHGLGKATRKNQ 261 599********************9..55779**********99999999886 PP >> sp|P46087-2|NOP2_HUMAN Isoform 2 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.7 0.0 0.00058 0.8 99 190 .. 379 473 .. 372 485 .. 0.79 Alignments for each domain: == domain 1 score: 11.7 bits; conditional E-value: 0.00058 -TT-EEEETT.-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--TTTGGGG CS Met_10 99 eegevVvdvf.AGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlpksaieF 183 +e e+++d+ A G+ + + + + +la+d n e k + n+++ v +++ Dgr++ + +drv++++p s + sp|P46087-2|NOP2_HUMAN 379 QEHERILDMCcAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTI-ISHYDGRQFPKvVGGFDRVLLDAPCSGTGV 464 7788999997244455555555556778899*************************.5578*****998899*******99988777 PP HHH..HHHH CS Met_10 184 ldk..vlaa 190 + k ++++ sp|P46087-2|NOP2_HUMAN 465 ISKdpAVKT 473 776555554 PP >> sp|P46087|NOP2_HUMAN Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.7 0.0 0.00058 0.8 99 190 .. 383 477 .. 376 489 .. 0.79 Alignments for each domain: == domain 1 score: 11.7 bits; conditional E-value: 0.00058 -TT-EEEETT.-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--TTTGGGGHH CS Met_10 99 eegevVvdvf.AGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlpksaieFld 185 +e e+++d+ A G+ + + + + +la+d n e k + n+++ v +++ Dgr++ + +drv++++p s + + sp|P46087|NOP2_HUMAN 383 QEHERILDMCcAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTI-ISHYDGRQFPKvVGGFDRVLLDAPCSGTGVIS 470 7788999997244455555555556778899*************************.5578*****998899*******9998877777 PP H..HHHH CS Met_10 186 k..vlaa 190 k ++++ sp|P46087|NOP2_HUMAN 471 KdpAVKT 477 6555554 PP >> sp|P46087-4|NOP2_HUMAN Isoform 4 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.6 0.0 0.00061 0.85 99 190 .. 416 510 .. 409 522 .. 0.79 Alignments for each domain: == domain 1 score: 11.6 bits; conditional E-value: 0.00061 -TT-EEEETT.-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEEE--TTTGGGG CS Met_10 99 eegevVvdvf.AGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvvmnlpksaieF 183 +e e+++d+ A G+ + + + + +la+d n e k + n+++ v +++ Dgr++ + +drv++++p s + sp|P46087-4|NOP2_HUMAN 416 QEHERILDMCcAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTI-ISHYDGRQFPKvVGGFDRVLLDAPCSGTGV 501 7788999997244455555555556778899*************************.5578*****998899*******99988777 PP HHH..HHHH CS Met_10 184 ldk..vlaa 190 + k ++++ sp|P46087-4|NOP2_HUMAN 502 ISKdpAVKT 510 776555554 PP >> sp|P21964-2|COMT_HUMAN Isoform Soluble of Catechol O-methyltransferase OS=Homo sapiens GN=COMT # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.5 0.0 0.00064 0.89 102 166 .. 60 127 .. 33 187 .. 0.83 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 0.00064 -EEEETT-TTTCCHHHCCHH.TTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..T CS Met_10 102 evVvdvfAGiGpfaipiaky.skakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..e 166 v +++ A G+ a+ +a++ s + r+++i++nP+ ++ + v+++v+ + + ++++i+ + sp|P21964-2|COMT_HUMAN 60 SVLLELGAYCGYSAVRMARLlSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPqlK 127 5777888999******9996377899************************************998443 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (199 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 1915 (0.021645); expected 1769.5 (0.02) Passed bias filter: 1608 (0.018175); expected 1769.5 (0.02) Passed Vit filter: 189 (0.00213624); expected 88.5 (0.001) Passed Fwd filter: 64 (0.000723385); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 64 [number of targets reported over threshold] # CPU time: 0.61u 0.03s 00:00:00.64 Elapsed: 00:00:00.24 # Mc/sec: 29079.30 // [ok]