# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Met_10.hmm.txt # target sequence database: proteomes/Saccharomyces_cerevisiae.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Met_10 [M=199] Accession: PF02475.15 Description: Met-10+ like-protein Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 1.1e-82 275.1 0.0 1.6e-82 274.6 0.0 1.2 1 sp|P38793|TRM5_YEAST tRNA (guanine(37)-N1)-methyltransferase 1.5e-09 36.3 0.0 2.8e-09 35.5 0.0 1.4 1 sp|Q04235|TYW2_YEAST tRNA wybutosine-synthesizing protein 2 7.9e-07 27.5 0.1 1.4e-06 26.7 0.1 1.4 1 sp|P15565|TRM1_YEAST tRNA (guanine(26)-N(2))-dimethyltransfe 0.00012 20.3 0.0 0.0002 19.6 0.0 1.3 1 sp|P41819|DIM1_YEAST Dimethyladenosine transferase OS=Saccha 0.0022 16.2 0.0 0.0039 15.4 0.0 1.3 1 sp|P53944|MTQ1_YEAST Mitochondrial N(5)-glutamine methyltran 0.003 15.8 0.0 0.0082 14.4 0.0 1.7 1 sp|P33753|TRM2_YEAST tRNA (uracil(54)-C(5))-methyltransferas ------ inclusion threshold ------ 0.013 13.7 0.0 0.019 13.2 0.0 1.3 1 sp|Q03920|MTQ2_YEAST eRF1 methyltransferase catalytic subuni 0.021 13.0 0.0 0.035 12.3 0.0 1.3 1 sp|P38074|HMT1_YEAST Protein arginine N-methyltransferase 1 Domain annotation for each sequence (and alignments): >> sp|P38793|TRM5_YEAST tRNA (guanine(37)-N1)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 274.6 0.0 2.1e-85 1.6e-82 2 199 .] 177 436 .. 176 436 .. 0.98 Alignments for each domain: == domain 1 score: 274.6 bits; conditional E-value: 2.1e-85 EEEEETTEEEEEB-TTSSHHHHHHHHHHHHHS.S-SCEEEE-S-SBTTTTB--EEEEEE.S-.SEEEEEETTEEEEEETTTS---GGGH CS Met_10 2 kfeiiGdvvilnlreelkeykkvigevildkt.kvktvlrkvsevegefRtfelevlaG.sdstetihkEngcrfklDvskvyfsskle 88 +f+i+G++++lnlr+e+k+++++ig+vildk+ k+++v++kvs+++++fRtf+++v+aG sds+++++kE++c+fk+D+skvy++s+l+ sp|P38793|TRM5_YEAST 177 GFTITGHIAHLNLRTEFKPFDSLIGQVILDKNnKIECVVDKVSSIATQFRTFPMKVIAGkSDSLVVEQKESNCTFKFDFSKVYWNSRLH 265 8*******************************9**************************9999************************** PP HHHHHHHTT.--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EE.... CS Met_10 89 aErerlakl.veegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..eqlad.... 170 +E+erl+k+ +++g+vV+dvfAG+Gpfa+p++k k+++vla+dlnPes+kylkeni+lNkv+k+vk++++Dg+++ir +ql++ sp|P38793|TRM5_YEAST 266 TEHERLVKQyFQPGQVVCDVFAGVGPFAVPAGK--KDVIVLANDLNPESYKYLKENIALNKVAKTVKSFNMDGADFIRqsPQLLQqwiq 352 *********9***********************..******************************************97766666899* PP ..........................................EEEE--TTTGGGGHHH...HHHHEEEE..........EEEEE CS Met_10 171 ..........................................rvvmnlpksaieFldk...vlaalkdg..........gvihy 199 ++vmnlp+sai+Fl++ ++aa+++g +v+++ sp|P38793|TRM5_YEAST 353 deeggkitiplplkkrhrsqqhndqqppqprtkeliipshisHYVMNLPDSAISFLGNfrgIFAAHTKGatdtiqmpwvHVHCF 436 **********************************************************999********9999****9999998 PP >> sp|Q04235|TYW2_YEAST tRNA wybutosine-synthesizing protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 35.5 0.0 3.8e-12 2.8e-09 81 151 .. 254 325 .. 239 346 .. 0.89 Alignments for each domain: == domain 1 score: 35.5 bits; conditional E-value: 3.8e-12 S---GGGHHHHHHHHTT--T..T-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TT CS Met_10 81 vyfsskleaErerlaklvee..gevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvek 151 +fs+++++E++r+ +++ + ++ Vvd++AGiG+f+ + a++++a +lnP sv+ lk+ +k N +k sp|Q04235|TYW2_YEAST 254 TMFSRGNIKEKKRVLTTFPDicNNDVVDLYAGIGYFTFSYLT-KGARTLFAFELNPWSVEGLKRGLKANGFNK 325 59***************98766999*************9876.57889****************999997665 PP >> sp|P15565|TRM1_YEAST tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 26.7 0.1 1.8e-09 1.4e-06 124 196 .. 157 234 .. 136 292 .. 0.81 Alignments for each domain: == domain 1 score: 26.7 bits; conditional E-value: 1.8e-09 SSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EE....EEEE--TT.TGGGGHHHHHHHEEEEEE CS Met_10 124 akrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqlad....rvvmnlpk.saieFldkvlaalkdggv 196 ++v+a+dl Pe+v+ +k+n++ N ve++vkp l D++ ++ +++a +v+ p+ + + F+d++++ +++gg+ sp|P15565|TRM1_YEAST 157 VREVIANDLLPEAVESIKRNVEYNSVENIVKPNLDDANVLMYRNKATnnkfHVIDLDPYgTVTPFVDAAIQSIEEGGL 234 579********************************9999887444444677666444441455688888888877765 PP >> sp|P41819|DIM1_YEAST Dimethyladenosine transferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=55929 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.6 0.0 2.7e-07 0.0002 97 163 .. 53 117 .. 16 140 .. 0.88 Alignments for each domain: == domain 1 score: 19.6 bits; conditional E-value: 2.7e-07 T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG- CS Met_10 97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrev 163 ++++ +vV++v G G +++ i +ak v+a++++P+ l++ ++ vek+++ +l+D + sp|P41819|DIM1_YEAST 53 QIRPSDVVLEVGPGTGNLTVRILE--QAKNVVAVEMDPRMAAELTKRVRGTPVEKKLEIMLGDFMKT 117 6899******************99..9999***************************9999997655 PP >> sp|P53944|MTQ1_YEAST Mitochondrial N(5)-glutamine methyltransferase MTQ1 OS=Saccharomyces cerevisiae (strain ATCC 20 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 15.4 0.0 5.1e-06 0.0039 104 150 .. 114 160 .. 106 170 .. 0.92 Alignments for each domain: == domain 1 score: 15.4 bits; conditional E-value: 5.1e-06 EEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-T CS Met_10 104 VvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkve 150 ++d f G G a+++++ + + aid+ +++k++ken+ Nkv+ sp|P53944|MTQ1_YEAST 114 ICDTFTGTGCIALALSHGIANCTFTAIDVSTRAIKLVKENMLKNKVS 160 8***************877788899*********************8 PP >> sp|P33753|TRM2_YEAST tRNA (uracil(54)-C(5))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 14.4 0.0 1.1e-05 0.0082 102 152 .. 490 538 .. 483 580 .. 0.87 Alignments for each domain: == domain 1 score: 14.4 bits; conditional E-value: 1.1e-05 -EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTC CS Met_10 102 evVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekv 152 + vd + G G f+i +k +v+++++ +sv + ++n k N ve+ sp|P33753|TRM2_YEAST 490 KFLVDAYCGSGLFSICSSK--GVDKVIGVEISADSVSFAEKNAKANGVENC 538 5689**************9..5556***********************985 PP >> sp|Q03920|MTQ2_YEAST eRF1 methyltransferase catalytic subunit MTQ2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.2 0.0 2.4e-05 0.019 89 182 .. 30 129 .. 8 142 .. 0.74 Alignments for each domain: == domain 1 score: 13.2 bits; conditional E-value: 2.4e-05 HHHHHHHTT-.-TT-EEEETT-TTTCCHHHCCHH....TTSSEEEEEES-HHHHHHHHHHHHHTT-TT.CEEEEES-GGG---TT-EEE CS Met_10 89 aErerlaklv.eegevVvdvfAGiGpfaipiaky....skakrvlaidlnPesvkylkeniklNkvek.vvkpileDgrevireqladr 171 +E+ l +++ + +V+++ G G + + + ++++ la+d+nP + + + klN ++ +++i++D + ir++++d sp|Q03920|MTQ2_YEAST 30 KEHDFLKQKFgNRLAIVCEIGSGSGIVTTFLMQNkiipQENSIHLAVDINPWALEATLDTAKLNSCKSsFLEVIQADLNSSIRNNQVDV 118 566666555413345666666666654443332111112455668********************9752789***************** PP EEE--TTTGGG CS Met_10 172 vvmnlpksaie 182 ++ n p+ e sp|Q03920|MTQ2_YEAST 119 LIFNPPYVPAE 129 **998876555 PP >> sp|P38074|HMT1_YEAST Protein arginine N-methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.3 0.0 4.6e-05 0.035 100 164 .. 58 120 .. 43 153 .. 0.83 Alignments for each domain: == domain 1 score: 12.3 bits; conditional E-value: 4.6e-05 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG-- CS Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevi 164 ++++V+dv G G +++ +ak++ k v+++d+ + +++ ke ++lN +++++ + + ++v sp|P38074|HMT1_YEAST 58 KDKIVLDVGCGTGILSMFAAKHGA-KHVIGVDMS-SIIEMAKELVELNGFSDKITLLRGKLEDVH 120 5689*****************875.56******7.579999**********99988887777765 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (199 nodes) Target sequences: 6049 (2936363 residues searched) Passed MSV filter: 202 (0.0333939); expected 121.0 (0.02) Passed bias filter: 146 (0.0241362); expected 121.0 (0.02) Passed Vit filter: 20 (0.00330633); expected 6.0 (0.001) Passed Fwd filter: 8 (0.00132253); expected 0.1 (1e-05) Initial search space (Z): 6049 [actual number of targets] Domain search space (domZ): 8 [number of targets reported over threshold] # CPU time: 0.07u 0.00s 00:00:00.07 Elapsed: 00:00:00.03 # Mc/sec: 19477.87 // [ok]