# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file:                  pfam_list/Met_10.hmm.txt
# target sequence database:        proteomes/Saccharomyces_cerevisiae.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query:       Met_10  [M=199]
Accession:   PF02475.15
Description: Met-10+ like-protein
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence             Description
    ------- ------ -----    ------- ------ -----   ---- --  --------             -----------
    1.1e-82  275.1   0.0    1.6e-82  274.6   0.0    1.2  1  sp|P38793|TRM5_YEAST  tRNA (guanine(37)-N1)-methyltransferase
    1.5e-09   36.3   0.0    2.8e-09   35.5   0.0    1.4  1  sp|Q04235|TYW2_YEAST  tRNA wybutosine-synthesizing protein 2 
    7.9e-07   27.5   0.1    1.4e-06   26.7   0.1    1.4  1  sp|P15565|TRM1_YEAST  tRNA (guanine(26)-N(2))-dimethyltransfe
    0.00012   20.3   0.0     0.0002   19.6   0.0    1.3  1  sp|P41819|DIM1_YEAST  Dimethyladenosine transferase OS=Saccha
     0.0022   16.2   0.0     0.0039   15.4   0.0    1.3  1  sp|P53944|MTQ1_YEAST  Mitochondrial N(5)-glutamine methyltran
      0.003   15.8   0.0     0.0082   14.4   0.0    1.7  1  sp|P33753|TRM2_YEAST  tRNA (uracil(54)-C(5))-methyltransferas
  ------ inclusion threshold ------
      0.013   13.7   0.0      0.019   13.2   0.0    1.3  1  sp|Q03920|MTQ2_YEAST  eRF1 methyltransferase catalytic subuni
      0.021   13.0   0.0      0.035   12.3   0.0    1.3  1  sp|P38074|HMT1_YEAST  Protein arginine N-methyltransferase 1 


Domain annotation for each sequence (and alignments):
>> sp|P38793|TRM5_YEAST  tRNA (guanine(37)-N1)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  274.6   0.0   2.1e-85   1.6e-82       2     199 .]     177     436 ..     176     436 .. 0.98

  Alignments for each domain:
  == domain 1  score: 274.6 bits;  conditional E-value: 2.1e-85
                           EEEEETTEEEEEB-TTSSHHHHHHHHHHHHHS.S-SCEEEE-S-SBTTTTB--EEEEEE.S-.SEEEEEETTEEEEEETTTS---GGGH CS
                Met_10   2 kfeiiGdvvilnlreelkeykkvigevildkt.kvktvlrkvsevegefRtfelevlaG.sdstetihkEngcrfklDvskvyfsskle 88 
                           +f+i+G++++lnlr+e+k+++++ig+vildk+ k+++v++kvs+++++fRtf+++v+aG sds+++++kE++c+fk+D+skvy++s+l+
  sp|P38793|TRM5_YEAST 177 GFTITGHIAHLNLRTEFKPFDSLIGQVILDKNnKIECVVDKVSSIATQFRTFPMKVIAGkSDSLVVEQKESNCTFKFDFSKVYWNSRLH 265
                           8*******************************9**************************9999************************** PP

                           HHHHHHHTT.--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EE.... CS
                Met_10  89 aErerlakl.veegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir..eqlad.... 170
                           +E+erl+k+ +++g+vV+dvfAG+Gpfa+p++k  k+++vla+dlnPes+kylkeni+lNkv+k+vk++++Dg+++ir  +ql++    
  sp|P38793|TRM5_YEAST 266 TEHERLVKQyFQPGQVVCDVFAGVGPFAVPAGK--KDVIVLANDLNPESYKYLKENIALNKVAKTVKSFNMDGADFIRqsPQLLQqwiq 352
                           *********9***********************..******************************************97766666899* PP

                           ..........................................EEEE--TTTGGGGHHH...HHHHEEEE..........EEEEE CS
                Met_10 171 ..........................................rvvmnlpksaieFldk...vlaalkdg..........gvihy 199
                                                                     ++vmnlp+sai+Fl++   ++aa+++g          +v+++
  sp|P38793|TRM5_YEAST 353 deeggkitiplplkkrhrsqqhndqqppqprtkeliipshisHYVMNLPDSAISFLGNfrgIFAAHTKGatdtiqmpwvHVHCF 436
                           **********************************************************999********9999****9999998 PP

>> sp|Q04235|TYW2_YEAST  tRNA wybutosine-synthesizing protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.5   0.0   3.8e-12   2.8e-09      81     151 ..     254     325 ..     239     346 .. 0.89

  Alignments for each domain:
  == domain 1  score: 35.5 bits;  conditional E-value: 3.8e-12
                           S---GGGHHHHHHHHTT--T..T-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TT CS
                Met_10  81 vyfsskleaErerlaklvee..gevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvek 151
                            +fs+++++E++r+ +++ +  ++ Vvd++AGiG+f+ +      a++++a +lnP sv+ lk+ +k N  +k
  sp|Q04235|TYW2_YEAST 254 TMFSRGNIKEKKRVLTTFPDicNNDVVDLYAGIGYFTFSYLT-KGARTLFAFELNPWSVEGLKRGLKANGFNK 325
                           59***************98766999*************9876.57889****************999997665 PP

>> sp|P15565|TRM1_YEAST  tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain 
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   0.1   1.8e-09   1.4e-06     124     196 ..     157     234 ..     136     292 .. 0.81

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 1.8e-09
                           SSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EE....EEEE--TT.TGGGGHHHHHHHEEEEEE CS
                Met_10 124 akrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqlad....rvvmnlpk.saieFldkvlaalkdggv 196
                            ++v+a+dl Pe+v+ +k+n++ N ve++vkp l D++ ++ +++a     +v+   p+ + + F+d++++ +++gg+
  sp|P15565|TRM1_YEAST 157 VREVIANDLLPEAVESIKRNVEYNSVENIVKPNLDDANVLMYRNKATnnkfHVIDLDPYgTVTPFVDAAIQSIEEGGL 234
                           579********************************9999887444444677666444441455688888888877765 PP

>> sp|P41819|DIM1_YEAST  Dimethyladenosine transferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=55929
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   2.7e-07    0.0002      97     163 ..      53     117 ..      16     140 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 2.7e-07
                           T--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG- CS
                Met_10  97 lveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrev 163
                           ++++ +vV++v  G G +++ i    +ak v+a++++P+    l++ ++   vek+++ +l+D  + 
  sp|P41819|DIM1_YEAST  53 QIRPSDVVLEVGPGTGNLTVRILE--QAKNVVAVEMDPRMAAELTKRVRGTPVEKKLEIMLGDFMKT 117
                           6899******************99..9999***************************9999997655 PP

>> sp|P53944|MTQ1_YEAST  Mitochondrial N(5)-glutamine methyltransferase MTQ1 OS=Saccharomyces cerevisiae (strain ATCC 20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   5.1e-06    0.0039     104     150 ..     114     160 ..     106     170 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 5.1e-06
                           EEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-T CS
                Met_10 104 VvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkve 150
                           ++d f G G  a+++++   + +  aid+  +++k++ken+  Nkv+
  sp|P53944|MTQ1_YEAST 114 ICDTFTGTGCIALALSHGIANCTFTAIDVSTRAIKLVKENMLKNKVS 160
                           8***************877788899*********************8 PP

>> sp|P33753|TRM2_YEAST  tRNA (uracil(54)-C(5))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0   1.1e-05    0.0082     102     152 ..     490     538 ..     483     580 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.1e-05
                           -EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTC CS
                Met_10 102 evVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekv 152
                           +  vd + G G f+i  +k     +v+++++  +sv + ++n k N ve+ 
  sp|P33753|TRM2_YEAST 490 KFLVDAYCGSGLFSICSSK--GVDKVIGVEISADSVSFAEKNAKANGVENC 538
                           5689**************9..5556***********************985 PP

>> sp|Q03920|MTQ2_YEAST  eRF1 methyltransferase catalytic subunit MTQ2 OS=Saccharomyces cerevisiae (strain ATCC 204508 /
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   2.4e-05     0.019      89     182 ..      30     129 ..       8     142 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.4e-05
                           HHHHHHHTT-.-TT-EEEETT-TTTCCHHHCCHH....TTSSEEEEEES-HHHHHHHHHHHHHTT-TT.CEEEEES-GGG---TT-EEE CS
                Met_10  89 aErerlaklv.eegevVvdvfAGiGpfaipiaky....skakrvlaidlnPesvkylkeniklNkvek.vvkpileDgrevireqladr 171
                           +E+  l +++ +   +V+++  G G  +  + +      ++++ la+d+nP + +   +  klN  ++  +++i++D +  ir++++d 
  sp|Q03920|MTQ2_YEAST  30 KEHDFLKQKFgNRLAIVCEIGSGSGIVTTFLMQNkiipQENSIHLAVDINPWALEATLDTAKLNSCKSsFLEVIQADLNSSIRNNQVDV 118
                           566666555413345666666666654443332111112455668********************9752789***************** PP

                           EEE--TTTGGG CS
                Met_10 172 vvmnlpksaie 182
                           ++ n p+   e
  sp|Q03920|MTQ2_YEAST 119 LIFNPPYVPAE 129
                           **998876555 PP

>> sp|P38074|HMT1_YEAST  Protein arginine N-methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   4.6e-05     0.035     100     164 ..      58     120 ..      43     153 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.6e-05
                           TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG-- CS
                Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevi 164
                           ++++V+dv  G G +++ +ak++  k v+++d+  + +++ ke ++lN  +++++ + +  ++v 
  sp|P38074|HMT1_YEAST  58 KDKIVLDVGCGTGILSMFAAKHGA-KHVIGVDMS-SIIEMAKELVELNGFSDKITLLRGKLEDVH 120
                           5689*****************875.56******7.579999**********99988887777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query model(s):                              1  (199 nodes)
Target sequences:                         6049  (2936363 residues searched)
Passed MSV filter:                       202  (0.0333939); expected 121.0 (0.02)
Passed bias filter:                      146  (0.0241362); expected 121.0 (0.02)
Passed Vit filter:                        20  (0.00330633); expected 6.0 (0.001)
Passed Fwd filter:                         8  (0.00132253); expected 0.1 (1e-05)
Initial search space (Z):               6049  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.07u 0.00s 00:00:00.07 Elapsed: 00:00:00.03
# Mc/sec: 19477.87
//
[ok]