# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Met_10.hmm.txt
# target sequence database: proteomes/Tetrahymena_thermophila.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Met_10 [M=199]
Accession: PF02475.15
Description: Met-10+ like-protein
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
9.9e-53 179.4 0.2 9.9e-53 179.4 0.2 1.8 2 tr|W7XD08|W7XD08_TETTS tRNA (guanine(37)-N1)-methyltransfera
3.2e-14 53.7 0.6 9.2e-14 52.2 0.1 1.9 2 tr|I7MA21|I7MA21_TETTS tRNA (Guanine(37)-N1)-methyltransfera
4.4e-07 30.4 4.7 5e-07 30.3 1.9 2.4 2 tr|Q22MG6|Q22MG6_TETTS RNA cap guanine-N2 methyltransferase
0.00052 20.4 0.1 0.0015 18.9 0.1 1.8 1 tr|I7MGF8|I7MGF8_TETTS RNA cap guanine-N2 methyltransferase
0.0014 19.0 0.1 0.0025 18.2 0.1 1.3 1 tr|I7MKV3|I7MKV3_TETTS Arginine N-methyltransferase OS=Tetra
------ inclusion threshold ------
0.032 14.5 0.1 0.16 12.3 0.0 2.1 2 tr|Q22HL7|Q22HL7_TETTS tRNA (guanine(26)-N(2))-dimethyltrans
0.036 14.4 0.0 0.052 13.9 0.0 1.3 1 tr|Q24FF7|Q24FF7_TETTS Methyltransferase OS=Tetrahymena ther
0.048 14.0 0.1 0.065 13.6 0.1 1.4 1 tr|I7M0Y7|I7M0Y7_TETTS Embryo-abundant protein, putative OS=
0.049 14.0 2.5 1.5 9.1 0.4 2.8 3 tr|Q22YU4|Q22YU4_TETTS Uncharacterized protein OS=Tetrahymen
Domain annotation for each sequence (and alignments):
>> tr|W7XD08|W7XD08_TETTS tRNA (guanine(37)-N1)-methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 G
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -2.1 0.2 1.4 4.1e+03 11 36 .. 19 45 .. 8 59 .. 0.48
2 ! 179.4 0.2 3.3e-56 9.9e-53 2 193 .. 124 328 .. 123 343 .. 0.94
Alignments for each domain:
== domain 1 score: -2.1 bits; conditional E-value: 1.4
EEEB-T.TSSHHHHHHHHHHHHHSS-S CS
Met_10 11 ilnlre.elkeykkvigevildktkvk 36
l++++ +++e + +++ ld+++vk
tr|W7XD08|W7XD08_TETTS 19 ALKVENkQINEVMNGVKDQFLDIQNVK 45
333332023334444444444444444 PP
== domain 2 score: 179.4 bits; conditional E-value: 3.3e-56
EEEEETTEEEEEB-TTSSHHHHHHHHHHHHHS.S-SCEEEE-S-SBTTTTB--EEEEEES-.SEEEEEETTEEEEEETTTS---GGG CS
Met_10 2 kfeiiGdvvilnlreelkeykkvigevildkt.kvktvlrkvsevegefRtfelevlaGsdstetihkEngcrfklDvskvyfsskl 87
++e++G++++ nl+ + +yk++ig+vi++k ++ktv++k ++++ ++Rt+ele++aG++++et+hkE c fklD+ kvyf s+l
tr|W7XD08|W7XD08_TETTS 124 GYETVGHIAHFNLKPQQYPYKHLIGQVIIEKFkNIKTVVNKLDKLHNVYRTPELEIMAGENKLETEHKEDKCIFKLDFEKVYFCSRL 210
89****************************999****************************************************** PP
HHHHHHHHTT--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EE.... CS
Met_10 88 eaErerlaklveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqlad.... 170
++Er r+ kl++++e+V+d+f G+Gp+ai +ak + +v+ +dlnP+ + yl n + N+ve++ +++D+r+v+ +
tr|W7XD08|W7XD08_TETTS 211 QTERDRVLKLIKPNETVLDLFCGVGPLAIRAAK--MGCKVICNDLNPHCYDYLLINREKNNVEDKTLCFNNDARKVVDILVSKeeyk 295
*********************************..88999************************************97333335688 PP
..........EEEE--TTTGGGGHHHHHHHEEE CS
Met_10 171 ..........rvvmnlpksaieFldkvlaalkd 193
+v mnlp ieF d lk+
tr|W7XD08|W7XD08_TETTS 296 kypsefhhfdHVYMNLPVDNIEFCDVFQGLLKK 328
9999999999*************9987666665 PP
>> tr|I7MA21|I7MA21_TETTS tRNA (Guanine(37)-N1)-methyltransferase, putative OS=Tetrahymena thermophila (strain SB210) O
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -1.6 0.0 0.97 2.9e+03 143 176 .. 90 123 .. 85 138 .. 0.74
2 ! 52.2 0.1 3.1e-17 9.2e-14 11 109 .. 139 240 .. 129 243 .. 0.92
Alignments for each domain:
== domain 1 score: -1.6 bits; conditional E-value: 0.97
HHHHTT-TTCEEEEES-GGG---TT-EEEEEE-- CS
Met_10 143 niklNkvekvvkpileDgrevireqladrvvmnl 176
i+ +ve + + i++D ++ e+++++v+ n
tr|I7MA21|I7MA21_TETTS 90 WIQEQNVEIIKHKIQKDISTFSLEEAIEKVINNK 123
5666677777778889999998888888888775 PP
== domain 2 score: 52.2 bits; conditional E-value: 3.1e-17
EEEB-TTSSHHHHHHHHHHHHHS..S-SCEEEE-S-S.BTTTTB--EEEEEES-.SEEEEEETTEEEEEETTTS---GGGHHHHHHH CS
Met_10 11 ilnlreelkeykkvigevildkt..kvktvlrkvsev.egefRtfelevlaGsdstetihkEngcrfklDvskvyfsskleaErerl 94
i++ +e+ k++k +i+ ++ldk ++ t+l+k+ + +f + ++e + G+++ + +E +c+f +D+sk y ++ ++Er r+
tr|I7MA21|I7MA21_TETTS 139 IIEFNENQKPFKDQIASIVLDKSqsSITTILQKKIDQdDEHFFVNSYEYVLGEKNFILDLQEGSCKFLIDISKFYINNYFQEERDRI 225
78999****************9878899*99987554388999******************************************** PP
HTT--TT-EEEETT- CS
Met_10 95 aklveegevVvdvfA 109
+l+++ e Vvd+f
tr|I7MA21|I7MA21_TETTS 226 LNLINDQESVVDLFG 240
*************96 PP
>> tr|Q22MG6|Q22MG6_TETTS RNA cap guanine-N2 methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=T
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -0.9 0.0 0.56 1.7e+03 117 153 .. 299 335 .. 295 343 .. 0.81
2 ! 30.3 1.9 1.7e-10 5e-07 100 174 .. 378 449 .. 371 556 .. 0.92
Alignments for each domain:
== domain 1 score: -0.9 bits; conditional E-value: 0.56
HCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCE CS
Met_10 117 piakyskakrvlaidlnPesvkylkeniklNkvekvv 153
++k v + ++n +s+ +l++ ++ N ++ +
tr|Q22MG6|Q22MG6_TETTS 299 YCKKKESYLLVKTLEKNFQSNSFLNSQVNQNPSKQSI 335
56665666678999****************9877766 PP
== domain 2 score: 30.3 bits; conditional E-value: 1.7e-10
TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT-EEEEEE CS
Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireqladrvvm 174
++++Vvd f G+G+ ++ ak +a++v+aid n v k ni+ k +++v++i++D ++ + +ad vv+
tr|Q22MG6|Q22MG6_TETTS 378 KNQIVVDAFCGVGYNTVQFAK--EASQVIAIDCNQVKVSHAKYNIESFKQQHKVEVIQSDFLQMK-KLKADTVVL 449
699******************..99***********************************99996.889998876 PP
>> tr|I7MGF8|I7MGF8_TETTS RNA cap guanine-N2 methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=T
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.9 0.1 5.2e-07 0.0015 93 151 .. 335 391 .. 328 400 .. 0.90
Alignments for each domain:
== domain 1 score: 18.9 bits; conditional E-value: 5.2e-07
HHHTT--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TT CS
Met_10 93 rlaklveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvek 151
r a++ + e +vdv +G+f+i+ + + ++v+ai+++P +++ ++n +v++
tr|I7MGF8|I7MGF8_TETTS 335 RRASQSNRRESIVDVSCAVGQFSIAFSN--QINQVIAIEKDPIRYQFARNNASIYNVQN 391
667889999******************8..9999*****************99888876 PP
>> tr|I7MKV3|I7MKV3_TETTS Arginine N-methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHERM_00
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.2 0.1 8.4e-07 0.0025 99 190 .. 125 218 .. 113 227 .. 0.85
Alignments for each domain:
== domain 1 score: 18.2 bits; conditional E-value: 8.4e-07
-TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEE...E--TTTGG CS
Met_10 99 eegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvv...mnlpksai 181
eg++V+d+ G G ++i +ak + ak v+++d n + + k +k N+++++++ i++ +ev +++d ++ m++ +
tr|I7MKV3|I7MKV3_TETTS 125 FEGKIVLDIGCGTGILSIFAAK-AGAKHVYGVD-NANIILHAKAIVKNNNLADKITLIQGKMEEVELpVEKVDIIIsewMGYFLLYE 209
589******************9.88999****9.778888889999*******************8867788877766677777777 PP
GGHHHHHHH CS
Met_10 182 eFldkvlaa 190
+ ld+vl+a
tr|I7MKV3|I7MKV3_TETTS 210 SMLDCVLDA 218
777777765 PP
>> tr|Q22HL7|Q22HL7_TETTS tRNA (guanine(26)-N(2))-dimethyltransferase OS=Tetrahymena thermophila (strain SB210) OX=3120
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -1.3 0.1 0.77 2.3e+03 33 53 .. 14 35 .. 3 51 .. 0.77
2 ? 12.3 0.0 5.3e-05 0.16 102 171 .. 145 226 .. 131 307 .. 0.79
Alignments for each domain:
== domain 1 score: -1.3 bits; conditional E-value: 0.77
S.S-SCEEEE-S-SBTTTTB-- CS
Met_10 33 t.kvktvlrkvsevegefRtfe 53
+ + +tvl+++++++++ Rtf
tr|Q22HL7|Q22HL7_TETTS 14 NkNKQTVLHNQTNIQAKRRTFI 35
3366899999999999999975 PP
== domain 2 score: 12.3 bits; conditional E-value: 5.3e-05
-EEEETT-TTTCCHHHCCHHTTS.SEEEEEES-HHHHHHHHHHHHHTT-T.TCEEEEES-GGG---TT-EE..........E CS
Met_10 102 evVvdvfAGiGpfaipiakyska.krvlaidlnPesvkylkeniklNkve.kvvkpileDgrevireqlad..........r 171
+++d + G ai +k k+ k+v+a+d+ +s k++ +n lN+++ ++++ l+D+ +++ eq++
tr|Q22HL7|Q22HL7_TETTS 145 ITILDALSASGLRAIRFSKELKDiKKVYANDISEASHKLMMDNFILNNLDlSKIEMTLKDAVQLMYEQKFRsssgdrnarfD 226
56777777778888888876665389**********************9856788999998888877666555555555542 PP
>> tr|Q24FF7|Q24FF7_TETTS Methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHERM_00865060 PE=4
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.9 0.0 1.7e-05 0.052 98 153 .. 63 116 .. 25 149 .. 0.82
Alignments for each domain:
== domain 1 score: 13.9 bits; conditional E-value: 1.7e-05
--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCE CS
Met_10 98 veegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvv 153
+ ++vV++v AG+G +++a+y+k +v+ d n ++++ n + + ++vv
tr|Q24FF7|Q24FF7_TETTS 63 IFRDKVVLEVGAGVGLSGLVCAQYAK--QVYITDGNDIVCELMEMNAQYAQNNNVV 116
45678******************766..5688999999999999999988887777 PP
>> tr|I7M0Y7|I7M0Y7_TETTS Embryo-abundant protein, putative OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHE
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.6 0.1 2.2e-05 0.065 94 168 .. 34 106 .. 28 258 .. 0.82
Alignments for each domain:
== domain 1 score: 13.6 bits; conditional E-value: 2.2e-05
HHTT--TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---TT- CS
Met_10 94 laklveegevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevireql 168
+ k + + e vd+ G G++ ++ + k + l+ d+ P+ ++ ++ i+ +++++vk+i D++ + + ++
tr|I7M0Y7|I7M0Y7_TETTS 34 ILKHAVDRENFVDIACGTGQLLFELSNHFK--FSLGTDISPKQIEVTNQKIQKKNLQDRVKAIVCDAHSLSKIST 106
66777788999************9999555..559*******************************999876333 PP
>> tr|Q22YU4|Q22YU4_TETTS Uncharacterized protein OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHERM_0012226
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.1 0.0 2.6 7.9e+03 151 165 .. 52 66 .. 36 76 .. 0.70
2 ? 9.1 0.4 0.00051 1.5 129 186 .. 195 257 .. 185 267 .. 0.79
3 ? 3.6 0.0 0.024 71 2 57 .. 276 333 .. 275 336 .. 0.86
Alignments for each domain:
== domain 1 score: -3.1 bits; conditional E-value: 2.6
TCEEEEES-GGG--- CS
Met_10 151 kvvkpileDgrevir 165
++v+ il+D+ ++i+
tr|Q22YU4|Q22YU4_TETTS 52 NIVQKILNDCSHIIQ 66
566667777776665 PP
== domain 2 score: 9.1 bits; conditional E-value: 0.00051
EEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---..TT-EEEEEE--TTT...GGGGHHH CS
Met_10 129 aidlnPesvkylkeniklNkvekvvkpileDgrevir..eqladrvvmnlpks...aieFldk 186
++ n e +y+++ ++ + +++vk ++eD+++++r ++ r+++n ++s ++F d+
tr|Q22YU4|Q22YU4_TETTS 195 SNANNQEVLRYIQKRSRRPRADQIVKKVKEDTKNLLRnyGNAQSRFILNNMYSkrmMEKFFDN 257
677789999***************************987678889**9987541113344444 PP
== domain 3 score: 3.6 bits; conditional E-value: 0.024
EEEEETTEEEEEB-TTSSHHHHHHHHHHHHHS.S-SCEEEE-S-SBTT.TTB--EEEE CS
Met_10 2 kfeiiGdvvilnlreelkeykkvigevildkt.kvktvlrkvsevege.fRtfelevl 57
+fe+ ++ ++ e+++eyk + e+ +d+ + +v+ s++++e +R+++++ +
tr|Q22YU4|Q22YU4_TETTS 276 NFEQFKNIWHVSNGEQYQEYKVLFREICFDFYeNHASVYVLGSQMRSEdTRKTHIKYI 333
5777788999*********************989999999999996543899998877 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (199 nodes)
Target sequences: 26971 (16912921 residues searched)
Passed MSV filter: 1806 (0.0669608); expected 539.4 (0.02)
Passed bias filter: 504 (0.0186867); expected 539.4 (0.02)
Passed Vit filter: 46 (0.00170554); expected 27.0 (0.001)
Passed Fwd filter: 9 (0.000333692); expected 0.3 (1e-05)
Initial search space (Z): 26971 [actual number of targets]
Domain search space (domZ): 9 [number of targets reported over threshold]
# CPU time: 0.29u 0.01s 00:00:00.30 Elapsed: 00:00:00.11
# Mc/sec: 30597.01
//
[ok]