# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltr_RsmB-F.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltr_RsmB-F [M=200] Accession: PF01189.16 Description: 16S rRNA methyltransferase RsmB/F Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 2.6e-83 280.8 0.0 3.9e-83 280.3 0.0 1.3 1 sp|P46087-3|NOP2_HUMAN Isoform 3 of Putative ribosomal RNA 3.8e-83 280.3 0.0 6.3e-83 279.6 0.0 1.4 1 sp|P46087-2|NOP2_HUMAN Isoform 2 of Putative ribosomal RNA 3.9e-83 280.3 0.0 6.4e-83 279.6 0.0 1.4 1 sp|P46087|NOP2_HUMAN Putative ribosomal RNA methyltransfe 4.2e-83 280.2 0.0 6.9e-83 279.5 0.0 1.3 1 sp|P46087-4|NOP2_HUMAN Isoform 4 of Putative ribosomal RNA 7.4e-45 155.3 0.0 1.2e-44 154.7 0.0 1.4 1 sp|Q8TEA1|NSUN6_HUMAN Putative methyltransferase NSUN6 OS= 4.8e-38 133.1 0.0 3.4e-34 120.5 0.0 2.3 2 sp|Q08J23-2|NSUN2_HUMAN Isoform 2 of tRNA (cytosine(34)-C(5) 5.5e-38 132.9 0.0 3.7e-34 120.4 0.0 2.3 2 sp|Q08J23|NSUN2_HUMAN tRNA (cytosine(34)-C(5))-methyltrans 4.6e-31 110.3 0.0 6.5e-31 109.8 0.0 1.2 1 sp|Q9H649|NSUN3_HUMAN Putative methyltransferase NSUN3 OS= 2.9e-27 97.9 0.0 4.8e-27 97.2 0.0 1.4 1 sp|Q96P11-5|NSUN5_HUMAN Isoform 5 of Putative methyltransfer 3.6e-27 97.6 0.0 6e-27 96.9 0.0 1.4 1 sp|Q96P11|NSUN5_HUMAN Putative methyltransferase NSUN5 OS= 4.5e-27 97.3 0.0 7.3e-27 96.6 0.0 1.4 1 sp|Q96P11-2|NSUN5_HUMAN Isoform 2 of Putative methyltransfer 4.5e-27 97.3 0.0 7.5e-27 96.5 0.0 1.4 1 sp|Q96P11-4|NSUN5_HUMAN Isoform 4 of Putative methyltransfer 6.2e-27 96.8 0.0 8.5e-27 96.4 0.0 1.2 1 sp|Q96CB9-4|NSUN4_HUMAN Isoform 4 of 5-methylcytosine rRNA m 8.4e-27 96.4 0.0 1.2e-26 95.9 0.0 1.2 1 sp|Q96CB9|NSUN4_HUMAN 5-methylcytosine rRNA methyltransfer 1.6e-21 79.2 0.0 1.6e-17 66.1 0.0 2.3 2 tr|G3V1R4|G3V1R4_HUMAN NOL1/NOP2/Sun domain family, member 2.5e-15 58.9 0.0 3.4e-15 58.5 0.0 1.1 1 sp|Q96CB9-3|NSUN4_HUMAN Isoform 3 of 5-methylcytosine rRNA m 3e-15 58.7 0.0 4e-15 58.3 0.0 1.2 1 sp|Q63ZY6-5|NSN5C_HUMAN Isoform 4 of Putative methyltransfer 6.2e-15 57.6 0.0 8.6e-15 57.2 0.0 1.3 1 sp|Q63ZY6|NSN5C_HUMAN Putative methyltransferase NSUN5C OS 4.6e-14 54.8 0.0 8.6e-07 31.1 0.0 2.1 2 sp|Q63ZY6-6|NSN5C_HUMAN Isoform 5 of Putative methyltransfer 1.1e-08 37.3 0.8 4e-08 35.4 0.5 2.0 1 sp|Q8NE18-2|NSUN7_HUMAN Isoform 2 of Putative methyltransfer 2e-08 36.4 0.4 8.4e-08 34.3 0.4 1.9 1 sp|Q8NE18|NSUN7_HUMAN Putative methyltransferase NSUN7 OS= 1.5e-07 33.5 0.0 1.6e-07 33.5 0.0 1.1 1 sp|Q63ZY6-2|NSN5C_HUMAN Isoform 2 of Putative methyltransfer 1.9e-07 33.2 0.1 3.5e-07 32.3 0.1 1.4 1 sp|Q96P11-3|NSUN5_HUMAN Isoform 3 of Putative methyltransfer 1.3e-06 30.5 0.1 2e-06 29.8 0.1 1.3 1 tr|F5GYR3|F5GYR3_HUMAN Putative ribosomal RNA methyltransfe 2.2e-06 29.7 0.0 3e-06 29.3 0.0 1.3 1 sp|Q3KNT7|NSN5B_HUMAN Putative NOL1/NOP2/Sun domain family 5.2e-05 25.2 0.0 5.8e-05 25.1 0.0 1.1 1 sp|Q63ZY6-4|NSN5C_HUMAN Isoform 3 of Putative methyltransfer 8e-05 24.6 0.0 0.00012 24.0 0.0 1.2 1 sp|P0C7V9|ME15P_HUMAN Putative methyltransferase-like prot 0.00011 24.2 0.0 0.00017 23.6 0.0 1.3 1 sp|A6NJ78-2|MET15_HUMAN Isoform 2 of Probable methyltransfer 0.00011 24.2 0.0 0.00018 23.5 0.0 1.3 1 sp|A6NJ78-4|MET15_HUMAN Isoform 4 of Probable methyltransfer 0.00021 23.3 0.0 0.00038 22.4 0.0 1.4 1 sp|A6NJ78|MET15_HUMAN Probable methyltransferase-like prot 0.00025 23.0 0.0 0.00028 22.8 0.0 1.1 1 sp|Q3KNT7-2|NSN5B_HUMAN Isoform 2 of Putative NOL1/NOP2/Sun 0.0005 22.0 0.0 0.00061 21.7 0.0 1.1 1 sp|Q3KNT7-3|NSN5B_HUMAN Isoform 3 of Putative NOL1/NOP2/Sun ------ inclusion threshold ------ 0.11 14.4 0.0 0.13 14.1 0.0 1.2 1 tr|J3QSE2|J3QSE2_HUMAN pre-rRNA-processing protein FTSJ3 (F 0.14 14.0 0.0 0.21 13.4 0.0 1.3 1 tr|J3KS36|J3KS36_HUMAN pre-rRNA-processing protein FTSJ3 (F 0.18 13.7 0.0 0.29 13.0 0.0 1.2 1 sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member 0.21 13.4 0.0 0.4 12.5 0.0 1.4 1 tr|M0R299|M0R299_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.22 13.4 0.1 0.34 12.8 0.1 1.3 1 sp|O00273-2|DFFA_HUMAN Isoform DFF35 of DNA fragmentation f 0.24 13.3 0.0 0.5 12.2 0.0 1.5 1 tr|M0QXL5|M0QXL5_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.25 13.2 0.0 0.4 12.5 0.0 1.3 1 tr|M0R0P1|M0R0P1_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.32 12.8 0.0 0.55 12.1 0.0 1.4 1 tr|M0R2Q4|M0R2Q4_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.42 12.5 0.0 0.71 11.7 0.0 1.4 1 sp|P22087|FBRL_HUMAN rRNA 2'-O-methyltransferase fibrilla 0.55 12.1 0.0 61 5.4 0.0 2.3 2 sp|Q9HBK9|AS3MT_HUMAN Arsenite methyltransferase OS=Homo s 0.6 12.0 0.0 1 11.2 0.0 1.4 1 tr|R4GMW7|R4GMW7_HUMAN rRNA/tRNA 2'-O-methyltransferase fib 0.6 12.0 0.0 1 11.2 0.0 1.4 1 sp|A6NHQ2|FBLL1_HUMAN rRNA/tRNA 2'-O-methyltransferase fib 0.89 11.4 0.0 3.6 9.5 0.0 1.8 2 sp|Q9UET6-2|TRM7_HUMAN Isoform 2 of Putative tRNA (cytidine 0.91 11.4 0.0 3.6 9.4 0.0 1.8 2 sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosin Domain annotation for each sequence (and alignments): >> sp|P46087-3|NOP2_HUMAN Isoform 3 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 280.3 0.0 2e-86 3.9e-83 1 200 [] 373 581 .. 373 581 .. 0.95 Alignments for each domain: == domain 1 score: 280.3 bits; conditional E-value: 2e-86 HHHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC--EEEEEEEE CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlggelfDriLlDa 87 +++Lapqe+e+ilD+c+aPGgKT+++a+lmkn+g+++A+dan+eRlk+v+ nl+rLgvtnti++++D+r+++kv+gg fDr+LlDa sp|P46087-3|NOP2_HUMAN 373 VMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG--FDRVLLDA 457 589*************************************************************************9..******** PP --CCGGGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHE....EEEEEEEEEES---CTCTHHHHHHHHHH-TTEEEESSBSTTS CS Methyltr_RsmB-F 88 PCsgtgvirrdpdvklrrkekdiaqlaklqkellsaaidll....kkgGvlvYsTCsvlveEneevieeaLkkredvelvetelsep 170 PCsgtgvi++dp+vk++++ekdi ++a+lqkell +aid++ k+gG+lvY+TCs++veEne+v+++aLkkr +v+lv+t l sp|P46087-3|NOP2_HUMAN 458 PCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVnatsKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGL--- 540 *************************************************************************9.9******55... PP TTSSECEEC..............T-EEE-TTTTS.-SEEEEEEE CS Methyltr_RsmB-F 171 kglklgeea..............gtlrllPhtenkdgffiaklk 200 ++g+e +t+r++Pht+n+dgffiak+k sp|P46087-3|NOP2_HUMAN 541 ---DFGQEGftrfrerrfhpslrSTRRFYPHTHNMDGFFIAKFK 581 ...44444444455678*************************96 PP >> sp|P46087-2|NOP2_HUMAN Isoform 2 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 279.6 0.0 3.3e-86 6.3e-83 1 200 [] 373 581 .. 373 581 .. 0.95 Alignments for each domain: == domain 1 score: 279.6 bits; conditional E-value: 3.3e-86 HHHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC--EEEEEEEE CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlggelfDriLlDa 87 +++Lapqe+e+ilD+c+aPGgKT+++a+lmkn+g+++A+dan+eRlk+v+ nl+rLgvtnti++++D+r+++kv+gg fDr+LlDa sp|P46087-2|NOP2_HUMAN 373 VMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG--FDRVLLDA 457 589*************************************************************************9..******** PP --CCGGGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHE....EEEEEEEEEES---CTCTHHHHHHHHHH-TTEEEESSBSTTS CS Methyltr_RsmB-F 88 PCsgtgvirrdpdvklrrkekdiaqlaklqkellsaaidll....kkgGvlvYsTCsvlveEneevieeaLkkredvelvetelsep 170 PCsgtgvi++dp+vk++++ekdi ++a+lqkell +aid++ k+gG+lvY+TCs++veEne+v+++aLkkr +v+lv+t l sp|P46087-2|NOP2_HUMAN 458 PCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVnatsKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGL--- 540 *************************************************************************9.9******55... PP TTSSECEEC..............T-EEE-TTTTS.-SEEEEEEE CS Methyltr_RsmB-F 171 kglklgeea..............gtlrllPhtenkdgffiaklk 200 ++g+e +t+r++Pht+n+dgffiak+k sp|P46087-2|NOP2_HUMAN 541 ---DFGQEGftrfrerrfhpslrSTRRFYPHTHNMDGFFIAKFK 581 ...44444444455678*************************96 PP >> sp|P46087|NOP2_HUMAN Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 279.6 0.0 3.3e-86 6.4e-83 1 200 [] 377 585 .. 377 585 .. 0.95 Alignments for each domain: == domain 1 score: 279.6 bits; conditional E-value: 3.3e-86 HHHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC--EEEEEEEE-- CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlggelfDriLlDaPC 89 +++Lapqe+e+ilD+c+aPGgKT+++a+lmkn+g+++A+dan+eRlk+v+ nl+rLgvtnti++++D+r+++kv+gg fDr+LlDaPC sp|P46087|NOP2_HUMAN 377 VMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG--FDRVLLDAPC 463 589*************************************************************************9..********** PP CCGGGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHE....EEEEEEEEEES---CTCTHHHHHHHHHH-TTEEEESSBSTTSTTSS CS Methyltr_RsmB-F 90 sgtgvirrdpdvklrrkekdiaqlaklqkellsaaidll....kkgGvlvYsTCsvlveEneevieeaLkkredvelvetelsepkglk 174 sgtgvi++dp+vk++++ekdi ++a+lqkell +aid++ k+gG+lvY+TCs++veEne+v+++aLkkr +v+lv+t l + sp|P46087|NOP2_HUMAN 464 SGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVnatsKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGL------D 545 ***********************************************************************9.9******55......4 PP ECEEC..............T-EEE-TTTTS.-SEEEEEEE CS Methyltr_RsmB-F 175 lgeea..............gtlrllPhtenkdgffiaklk 200 +g+e +t+r++Pht+n+dgffiak+k sp|P46087|NOP2_HUMAN 546 FGQEGftrfrerrfhpslrSTRRFYPHTHNMDGFFIAKFK 585 4444444455678*************************96 PP >> sp|P46087-4|NOP2_HUMAN Isoform 4 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 279.5 0.0 3.6e-86 6.9e-83 1 200 [] 410 618 .. 410 618 .. 0.95 Alignments for each domain: == domain 1 score: 279.5 bits; conditional E-value: 3.6e-86 HHHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC--EEEEEEEE CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlggelfDriLlDa 87 +++Lapqe+e+ilD+c+aPGgKT+++a+lmkn+g+++A+dan+eRlk+v+ nl+rLgvtnti++++D+r+++kv+gg fDr+LlDa sp|P46087-4|NOP2_HUMAN 410 VMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG--FDRVLLDA 494 589*************************************************************************9..******** PP --CCGGGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHE....EEEEEEEEEES---CTCTHHHHHHHHHH-TTEEEESSBSTTS CS Methyltr_RsmB-F 88 PCsgtgvirrdpdvklrrkekdiaqlaklqkellsaaidll....kkgGvlvYsTCsvlveEneevieeaLkkredvelvetelsep 170 PCsgtgvi++dp+vk++++ekdi ++a+lqkell +aid++ k+gG+lvY+TCs++veEne+v+++aLkkr +v+lv+t l sp|P46087-4|NOP2_HUMAN 495 PCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVnatsKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGL--- 577 *************************************************************************9.9******55... PP TTSSECEEC..............T-EEE-TTTTS.-SEEEEEEE CS Methyltr_RsmB-F 171 kglklgeea..............gtlrllPhtenkdgffiaklk 200 ++g+e +t+r++Pht+n+dgffiak+k sp|P46087-4|NOP2_HUMAN 578 ---DFGQEGftrfrerrfhpslrSTRRFYPHTHNMDGFFIAKFK 618 ...44444444455678*************************96 PP >> sp|Q8TEA1|NSUN6_HUMAN Putative methyltransferase NSUN6 OS=Homo sapiens GN=NSUN6 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 154.7 0.0 6e-48 1.2e-44 3 166 .. 229 400 .. 227 464 .. 0.89 Alignments for each domain: == domain 1 score: 154.7 bits; conditional E-value: 6e-48 HH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHH.HHCC..........-- CS Methyltr_RsmB-F 3 lLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidk.vlgg..........el 79 +L+pq++e+ilDlcaaPGgKTthia+lm+++g+v+A+d+ ++++++++n Lg++++ ++ D++k k ++ + e sp|Q8TEA1|NSUN6_HUMAN 229 VLNPQPGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKIFNKVEKIKQNALLLGLNSIRAFCFDGTKAVKlDMVEdtegeppflpES 316 8****************************************************************9987541344467889******* PP EEEEEEEE--CCGGGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTEEEESSB CS Methyltr_RsmB-F 80 fDriLlDaPCsgtgvirrdpdvklrrkekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredvelvete 166 fDriLlDaPCsg+g ++p++ + + k++a+++ lq++l++aa++llk++GvlvYsTC+++++Enee+++ aL k + +l++ e sp|Q8TEA1|NSUN6_HUMAN 317 FDRILLDAPCSGMG---QRPNMACTWSVKEVASYQPLQRKLFTAAVQLLKPEGVLVYSTCTITLAENEEQVAWALTKFPCLQLQPQE 400 ************98...689999999999************************************************9999998874 PP >> sp|Q08J23-2|NSUN2_HUMAN Isoform 2 of tRNA (cytosine(34)-C(5))-methyltransferase OS=Homo sapiens GN=NSUN2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 120.5 0.0 1.8e-37 3.4e-34 2 159 .. 135 306 .. 134 334 .. 0.89 2 ! 10.3 0.0 0.001 1.9 156 199 .. 349 392 .. 344 393 .. 0.84 Alignments for each domain: == domain 1 score: 120.5 bits; conditional E-value: 1.8e-37 HHH---TT-EEEECS-TT-HHHHHHHHHTT.......TTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC... CS Methyltr_RsmB-F 2 llLapqeeetilDlcaaPGgKTthiaelmk.......nkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg... 77 llL+ +++ +ilD+caaPG+KTt + e+++ ++g v+A+d++++R +++ krL+ ++v++ Da+ i++ + sp|Q08J23-2|NSUN2_HUMAN 135 LLLNVRPHHKILDMCAAPGSKTTQLIEMLHadmnvpfPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQIDvdg 220 5899***********************976222233347889***********************************998877778 PP ....--EEEEEEEE--CCGGGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TT CS Methyltr_RsmB-F 78 ....elfDriLlDaPCsgtgvirrdpdvklrrkekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkred 159 ++DriL D+PCsg g++r++ dv + + + ql+ lq ++ + +++l +gG +vYsTCs+++ E+e+vi+++L+k e sp|Q08J23-2|NSUN2_HUMAN 221 rkeiLFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEG 306 9987789*********************6666888999*******************************************99864 PP == domain 2 score: 10.3 bits; conditional E-value: 0.001 H-TTEEEESSBSTTSTTSSECEECT-EEE-TTTTS.-SEEEEEE CS Methyltr_RsmB-F 156 kredvelvetelsepkglklgeeagtlrllPhtenkdgffiakl 199 ++ +++ + ++ ++p++l+ + + lr+lPh++n+ gff+a l sp|Q08J23-2|NSUN2_HUMAN 349 RHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVL 392 56667777778888999888888889****************87 PP >> sp|Q08J23|NSUN2_HUMAN tRNA (cytosine(34)-C(5))-methyltransferase OS=Homo sapiens GN=NSUN2 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 120.4 0.0 1.9e-37 3.7e-34 2 159 .. 170 341 .. 169 369 .. 0.89 2 ! 10.3 0.0 0.001 2 156 199 .. 384 427 .. 378 428 .. 0.84 Alignments for each domain: == domain 1 score: 120.4 bits; conditional E-value: 1.9e-37 HHH---TT-EEEECS-TT-HHHHHHHHHTT.......TTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC..... CS Methyltr_RsmB-F 2 llLapqeeetilDlcaaPGgKTthiaelmk.......nkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg..... 77 llL+ +++ +ilD+caaPG+KTt + e+++ ++g v+A+d++++R +++ krL+ ++v++ Da+ i++ + sp|Q08J23|NSUN2_HUMAN 170 LLLNVRPHHKILDMCAAPGSKTTQLIEMLHadmnvpfPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQIDvdgrk 257 5899***********************976222233347889***********************************99887777899 PP ..--EEEEEEEE--CCGGGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TT CS Methyltr_RsmB-F 78 ..elfDriLlDaPCsgtgvirrdpdvklrrkekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkred 159 ++DriL D+PCsg g++r++ dv + + + ql+ lq ++ + +++l +gG +vYsTCs+++ E+e+vi+++L+k e sp|Q08J23|NSUN2_HUMAN 258 eiLFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEG 341 87789*********************6666888999*******************************************99864 PP == domain 2 score: 10.3 bits; conditional E-value: 0.001 H-TTEEEESSBSTTSTTSSECEECT-EEE-TTTTS.-SEEEEEE CS Methyltr_RsmB-F 156 kredvelvetelsepkglklgeeagtlrllPhtenkdgffiakl 199 ++ +++ + ++ ++p++l+ + + lr+lPh++n+ gff+a l sp|Q08J23|NSUN2_HUMAN 384 RHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVL 427 56667777778888999888888889****************87 PP >> sp|Q9H649|NSUN3_HUMAN Putative methyltransferase NSUN3 OS=Homo sapiens GN=NSUN3 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 109.8 0.0 3.4e-34 6.5e-31 2 199 .. 125 331 .. 124 332 .. 0.80 Alignments for each domain: == domain 1 score: 109.8 bits; conditional E-value: 3.4e-34 HHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--....SEEEEES-CCCCHHHHCC--EEEEEE CS Methyltr_RsmB-F 2 llLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvt....ntivleaDarkidkvlggelfDriLl 85 l+L+++++e++lDlcaaPGgK +++ ++ g + ++ ++ Rl+ + ++l+ + + ++v+e D+rk+ + e+fD++L+ sp|Q9H649|NSUN3_HUMAN 125 LALELRDGEKVLDLCAAPGGKSIALLQC-ACPGYLHCNEYDSLRLRWLRQTLESFIPQplinVIKVSELDGRKMGDAQP-EMFDKVLV 210 789************************9.9**********************997544344367899*******88887.5******* PP EE--CCGG.GTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTEEEESSB...... CS Methyltr_RsmB-F 86 DaPCsgtg.virrdpdvklrrkekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredvelvete...... 166 DaPCs + + k + + ++ +l lq ell +ai+ l++gG+lvYsTC++ +En+ vi e+L+++ ++ ++++ sp|Q9H649|NSUN3_HUMAN 211 DAPCSNDRsWLFSSDSQKASCRISQRRNLPLLQIELLRSAIKALRPGGILVYSTCTLSKAENQDVISEILNSHGNIMPMDIKgiartc 298 *****875156666667777788888999********************************************987655543111111 PP STTSTTSSECEECT-EEE-TTTTS..-SEEEEEE CS Methyltr_RsmB-F 167 lsepkglklgeeagtlrllPhten.kdgffiakl 199 ++++ + +g+e l ++P++ + ++++akl sp|Q9H649|NSUN3_HUMAN 299 SHDFTFAPTGQEC-GLLVIPDKGKaWGPMYVAKL 331 3344444444444.56667766441466888887 PP >> sp|Q96P11-5|NSUN5_HUMAN Isoform 5 of Putative methyltransferase NSUN5 OS=Homo sapiens GN=NSUN5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 97.2 0.0 2.5e-30 4.8e-27 1 198 [. 181 383 .. 181 385 .. 0.80 Alignments for each domain: == domain 1 score: 97.2 bits; conditional E-value: 2.5e-30 HHHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCH.HHHCC--EEEEEE CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkid.kvlggelfDriLl 85 a+lL+p ++ +++D+caaPG KT+h+a+l+kn+g+++A d +++Rl ++a+ l r gv + e D ++ ++ + + iLl sp|Q96P11-5|NSUN5_HUMAN 181 AMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSpSDPRYHEVHYILL 266 689********************************************************99999*998776414455589****** PP EE--CCGGGTTT-TTHHHH.-CC..HHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BS CS Methyltr_RsmB-F 86 DaPCsgtgvirrdpdvklrrkek..diaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredv.elvet.el 167 D Csg g+ +r+ + +++ + +la q++ l a++ + lvYsTCs+ eEne v+ +aL++++ + +l + ++ sp|Q96P11-5|NSUN5_HUMAN 267 DPSCSGSGMPSRQLEEPGAGTPSpvRLHALAGFQQRALCHALTF-PSLQRLVYSTCSLCQEENEDVVRDALQQNPGAfRLAPAlPA 351 ************98877666655115678888777776665544.34447**********************99864277665222 PP TTSTTSS..ECEECT-EEE-TTTTS.-SEEEEE CS Methyltr_RsmB-F 168 sepkglk..lgeeagtlrllPhtenkdgffiak 198 +gl+ g e+ lr P+t gff+a sp|Q96P11-5|NSUN5_HUMAN 352 WPHRGLStfPGAEH-CLRASPETTLSSGFFVAV 383 22233321134444.89999**********996 PP >> sp|Q96P11|NSUN5_HUMAN Putative methyltransferase NSUN5 OS=Homo sapiens GN=NSUN5 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 96.9 0.0 3.1e-30 6e-27 1 198 [. 219 421 .. 219 423 .. 0.80 Alignments for each domain: == domain 1 score: 96.9 bits; conditional E-value: 3.1e-30 HHHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCH.HHHCC--EEEEEEEE CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkid.kvlggelfDriLlDa 87 a+lL+p ++ +++D+caaPG KT+h+a+l+kn+g+++A d +++Rl ++a+ l r gv + e D ++ ++ + + iLlD sp|Q96P11|NSUN5_HUMAN 219 AMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSpSDPRYHEVHYILLDP 306 689********************************************************99999*998776414455589******** PP --CCGGGTTT-TTHHHH.-CC..HHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BSTTST CS Methyltr_RsmB-F 88 PCsgtgvirrdpdvklrrkek..diaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredv.elvet.elsepk 171 Csg g+ +r+ + +++ + +la q++ l a++ + lvYsTCs+ eEne v+ +aL++++ + +l + ++ + sp|Q96P11|NSUN5_HUMAN 307 SCSGSGMPSRQLEEPGAGTPSpvRLHALAGFQQRALCHALTF-PSLQRLVYSTCSLCQEENEDVVRDALQQNPGAfRLAPAlPAWPHR 393 **********98877666655115678888777776665544.34447**********************998642776652222223 PP TSS..ECEECT-EEE-TTTTS.-SEEEEE CS Methyltr_RsmB-F 172 glk..lgeeagtlrllPhtenkdgffiak 198 gl+ g e+ lr P+t gff+a sp|Q96P11|NSUN5_HUMAN 394 GLStfPGAEH-CLRASPETTLSSGFFVAV 421 3321134444.89999**********996 PP >> sp|Q96P11-2|NSUN5_HUMAN Isoform 2 of Putative methyltransferase NSUN5 OS=Homo sapiens GN=NSUN5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 96.6 0.0 3.8e-30 7.3e-27 1 198 [. 219 421 .. 219 423 .. 0.80 Alignments for each domain: == domain 1 score: 96.6 bits; conditional E-value: 3.8e-30 HHHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCH.HHHCC--EEEEEE CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkid.kvlggelfDriLl 85 a+lL+p ++ +++D+caaPG KT+h+a+l+kn+g+++A d +++Rl ++a+ l r gv + e D ++ ++ + + iLl sp|Q96P11-2|NSUN5_HUMAN 219 AMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSpSDPRYHEVHYILL 304 689********************************************************99999*998776414455589****** PP EE--CCGGGTTT-TTHHHH.-CC..HHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BS CS Methyltr_RsmB-F 86 DaPCsgtgvirrdpdvklrrkek..diaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredv.elvet.el 167 D Csg g+ +r+ + +++ + +la q++ l a++ + lvYsTCs+ eEne v+ +aL++++ + +l + ++ sp|Q96P11-2|NSUN5_HUMAN 305 DPSCSGSGMPSRQLEEPGAGTPSpvRLHALAGFQQRALCHALTF-PSLQRLVYSTCSLCQEENEDVVRDALQQNPGAfRLAPAlPA 389 ************98877666655115678888777776665544.34447**********************99864277665222 PP TTSTTSS..ECEECT-EEE-TTTTS.-SEEEEE CS Methyltr_RsmB-F 168 sepkglk..lgeeagtlrllPhtenkdgffiak 198 +gl+ g e+ lr P+t gff+a sp|Q96P11-2|NSUN5_HUMAN 390 WPHRGLStfPGAEH-CLRASPETTLSSGFFVAV 421 22233321134444.89999**********996 PP >> sp|Q96P11-4|NSUN5_HUMAN Isoform 4 of Putative methyltransferase NSUN5 OS=Homo sapiens GN=NSUN5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 96.5 0.0 3.9e-30 7.5e-27 1 198 [. 219 421 .. 219 423 .. 0.80 Alignments for each domain: == domain 1 score: 96.5 bits; conditional E-value: 3.9e-30 HHHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCH.HHHCC--EEEEEE CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkid.kvlggelfDriLl 85 a+lL+p ++ +++D+caaPG KT+h+a+l+kn+g+++A d +++Rl ++a+ l r gv + e D ++ ++ + + iLl sp|Q96P11-4|NSUN5_HUMAN 219 AMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSpSDPRYHEVHYILL 304 689********************************************************99999*998776414455589****** PP EE--CCGGGTTT-TTHHHH.-CC..HHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BS CS Methyltr_RsmB-F 86 DaPCsgtgvirrdpdvklrrkek..diaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredv.elvet.el 167 D Csg g+ +r+ + +++ + +la q++ l a++ + lvYsTCs+ eEne v+ +aL++++ + +l + ++ sp|Q96P11-4|NSUN5_HUMAN 305 DPSCSGSGMPSRQLEEPGAGTPSpvRLHALAGFQQRALCHALTF-PSLQRLVYSTCSLCQEENEDVVRDALQQNPGAfRLAPAlPA 389 ************98877666655115678888777776665544.34447**********************99864277665222 PP TTSTTSS..ECEECT-EEE-TTTTS.-SEEEEE CS Methyltr_RsmB-F 168 sepkglk..lgeeagtlrllPhtenkdgffiak 198 +gl+ g e+ lr P+t gff+a sp|Q96P11-4|NSUN5_HUMAN 390 WPHRGLStfPGAEH-CLRASPETTLSSGFFVAV 421 22233321134444.89999**********996 PP >> sp|Q96CB9-4|NSUN4_HUMAN Isoform 4 of 5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 96.4 0.0 4.4e-30 8.5e-27 2 169 .. 118 291 .. 117 304 .. 0.84 Alignments for each domain: == domain 1 score: 96.4 bits; conditional E-value: 4.4e-30 HHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--......SEEEEES-CCCCHHHHCC--EE CS Methyltr_RsmB-F 2 llLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvt......ntivleaDarkidkvlggelfD 81 l+L +q+++ +lDlcaaPGgKT +++ + ++ A+d + +R+ r+++ l+ + ++ v++ D+rk + g+ ++D sp|Q96CB9-4|NSUN4_HUMAN 118 LALGLQPGDIVLDLCAAPGGKTLALLQT-GCCRNLAANDLSPSRIARLQKILHSYVPEeirdgnQVRVTSWDGRKWGELEGD-TYD 201 67999**********************9.999*****************999976444344554689*********888885.*** PP EEEEEE--CCG..GGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTEEEESS CS Methyltr_RsmB-F 82 riLlDaPCsgt..gvirrdpdvklrrkekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredvelvet 165 r+L+D+PC++ + ++++ r ++k+ + l lq +ll a + +k+gG +vYsTCs+ ne v++ a++ ++ ++++ sp|Q96CB9-4|NSUN4_HUMAN 202 RVLVDVPCTTDrhSLHEEENNIFKRSRKKERQILPVLQVQLLAAGLLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQV 287 ********98621445556667444455566667889***********************************99998888877777 PP BSTT CS Methyltr_RsmB-F 166 else 169 ++++ sp|Q96CB9-4|NSUN4_HUMAN 288 QVED 291 7665 PP >> sp|Q96CB9|NSUN4_HUMAN 5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 95.9 0.0 6.3e-30 1.2e-26 2 169 .. 167 340 .. 166 352 .. 0.84 Alignments for each domain: == domain 1 score: 95.9 bits; conditional E-value: 6.3e-30 HHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--......SEEEEES-CCCCHHHHCC--EEEE CS Methyltr_RsmB-F 2 llLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvt......ntivleaDarkidkvlggelfDri 83 l+L +q+++ +lDlcaaPGgKT +++ + ++ A+d + +R+ r+++ l+ + ++ v++ D+rk + g+ ++Dr+ sp|Q96CB9|NSUN4_HUMAN 167 LALGLQPGDIVLDLCAAPGGKTLALLQT-GCCRNLAANDLSPSRIARLQKILHSYVPEeirdgnQVRVTSWDGRKWGELEGD-TYDRV 252 67999**********************9.999*****************999976444344554689*********888885.***** PP EEEE--CCG..GGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTEEEESSBSTT CS Methyltr_RsmB-F 84 LlDaPCsgt..gvirrdpdvklrrkekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredvelvetelse 169 L+D+PC++ + ++++ r ++k+ + l lq +ll a + +k+gG +vYsTCs+ ne v++ a++ ++ ++++++++ sp|Q96CB9|NSUN4_HUMAN 253 LVDVPCTTDrhSLHEEENNIFKRSRKKERQILPVLQVQLLAAGLLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVED 340 ******98621445556667444455566667889***********************************999988888777777665 PP >> tr|G3V1R4|G3V1R4_HUMAN NOL1/NOP2/Sun domain family, member 2, isoform CRA_b OS=Homo sapiens GN=NSUN2 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 66.1 0.0 8.2e-21 1.6e-17 67 159 .. 6 105 .. 1 132 [. 0.82 2 ! 10.9 0.0 0.00068 1.3 156 199 .. 148 191 .. 143 192 .. 0.84 Alignments for each domain: == domain 1 score: 66.1 bits; conditional E-value: 8.2e-21 -CCCCHHHHCC.......--EEEEEEEE--CCGGGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCT CS Methyltr_RsmB-F 67 Darkidkvlgg.......elfDriLlDaPCsgtgvirrdpdvklrrkekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlveEn 146 Da+ i++ + ++DriL D+PCsg g++r++ dv + + + ql+ lq ++ + +++l +gG +vYsTCs+++ E+ tr|G3V1R4|G3V1R4_HUMAN 6 DASSIPRLQIDvdgrkeiLFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIED 92 555555444444445554579*********************6666888999*********************************** PP HHHHHHHHHH-TT CS Methyltr_RsmB-F 147 eevieeaLkkred 159 e+vi+++L+k e tr|G3V1R4|G3V1R4_HUMAN 93 EAVIASLLEKSEG 105 ********99864 PP == domain 2 score: 10.9 bits; conditional E-value: 0.00068 H-TTEEEESSBSTTSTTSSECEECT-EEE-TTTTS.-SEEEEEE CS Methyltr_RsmB-F 156 kredvelvetelsepkglklgeeagtlrllPhtenkdgffiakl 199 ++ +++ + ++ ++p++l+ + + lr+lPh++n+ gff+a l tr|G3V1R4|G3V1R4_HUMAN 148 RHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVL 191 56667777778888999888888889****************87 PP >> sp|Q96CB9-3|NSUN4_HUMAN Isoform 3 of 5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 58.5 0.0 1.8e-18 3.4e-15 60 169 .. 32 142 .. 22 156 .. 0.82 Alignments for each domain: == domain 1 score: 58.5 bits; conditional E-value: 1.8e-18 SEEEEES-CCCCHHHHCC--EEEEEEEE--CCG..GGTTT-TTHHHH.-CCHHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---C CS Methyltr_RsmB-F 60 ntivleaDarkidkvlggelfDriLlDaPCsgt..gvirrdpdvklrrkekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlv 143 ++ v++ D+rk + g+ ++Dr+L+D+PC++ + ++++ r ++k+ + l lq +ll a + +k+gG +vYsTCs+ sp|Q96CB9-3|NSUN4_HUMAN 32 QVRVTSWDGRKWGELEGD-TYDRVLVDVPCTTDrhSLHEEENNIFKRSRKKERQILPVLQVQLLAAGLLATKPGGHVVYSTCSLSH 116 4789999*****888885.***********98621445556667444455566667889*************************** PP TCTHHHHHHHHHH-TTEEEESSBSTT CS Methyltr_RsmB-F 144 eEneevieeaLkkredvelvetelse 169 ne v++ a++ ++ ++++++++ sp|Q96CB9-3|NSUN4_HUMAN 117 LQNEYVVQGAIELLANQYSIQVQVED 142 ********999988888887777766 PP >> sp|Q63ZY6-5|NSN5C_HUMAN Isoform 4 of Putative methyltransferase NSUN5C OS=Homo sapiens GN=NSUN5P2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 58.3 0.0 2.1e-18 4e-15 22 198 .. 56 237 .. 35 239 .. 0.78 Alignments for each domain: == domain 1 score: 58.3 bits; conditional E-value: 2.1e-18 HHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE--CCGGGTTT-TTHHHH.- CS Methyltr_RsmB-F 22 KTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDaPCsgtgvirrdpdvklrrk 106 KT+h+a+l+kn+g+++A d +++Rl ++a+ l gv + e D ++ + + +LlD Csg g+ +r+ + + sp|Q63ZY6-5|NSN5C_HUMAN 56 KTSHLAALLKNQGKIFAFDLDARRLASMATLLAWAGVSCCELAEEDFLAVSPLDPRyREVHYVLLDPSCSGSGMPSRQLEEPGAGT 141 9*************************************99******8777544333488******************988776666 PP CC..HHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BSTTSTT..SSECEECT-EEE-T CS Methyltr_RsmB-F 107 ek..diaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredv.elvet.elsepkg..lklgeeagtlrllP 186 ++ + +la q++ l a++ + lvYs Cs+ eEne ++++aL++++ + +l + ++ +g + g e+ lr P sp|Q63ZY6-5|NSN5C_HUMAN 142 PSpvRLHALAGFQQRALCHALTF-PSLQRLVYSMCSLCQEENEDMVQDALQQNPGAfRLAPAlPARPHRGlsTFPGAEH-CLRASP 225 55115678888777776665544.34447***********************986427766513333333103345555.8999** PP TTTS.-SEEEEE CS Methyltr_RsmB-F 187 htenkdgffiak 198 +t gff+a sp|Q63ZY6-5|NSN5C_HUMAN 226 KTTLSGGFFVAV 237 *********996 PP >> sp|Q63ZY6|NSN5C_HUMAN Putative methyltransferase NSUN5C OS=Homo sapiens GN=NSUN5P2 PE=5 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 57.2 0.0 4.5e-18 8.6e-15 22 198 .. 56 237 .. 35 239 .. 0.78 Alignments for each domain: == domain 1 score: 57.2 bits; conditional E-value: 4.5e-18 HHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE--CCGGGTTT-TTHHHH.-CC CS Methyltr_RsmB-F 22 KTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDaPCsgtgvirrdpdvklrrkek 108 KT+h+a+l+kn+g+++A d +++Rl ++a+ l gv + e D ++ + + +LlD Csg g+ +r+ + +++ sp|Q63ZY6|NSN5C_HUMAN 56 KTSHLAALLKNQGKIFAFDLDARRLASMATLLAWAGVSCCELAEEDFLAVSPLDPRyREVHYVLLDPSCSGSGMPSRQLEEPGAGTPS 143 9*************************************99******8777544333488******************98877666655 PP ..HHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BSTTSTT..SSECEECT-EEE-TTTTS CS Methyltr_RsmB-F 109 ..diaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredv.elvet.elsepkg..lklgeeagtlrllPhten 190 + +la q++ l a++ + lvYs Cs+ eEne ++++aL++++ + +l + ++ +g + g e+ lr P+t sp|Q63ZY6|NSN5C_HUMAN 144 pvRLHALAGFQQRALCHALTF-PSLQRLVYSMCSLCQEENEDMVQDALQQNPGAfRLAPAlPARPHRGlsTFPGAEH-CLRASPKTTL 229 115678888777776665544.34447***********************986427766513333333103345555.8999****** PP .-SEEEEE CS Methyltr_RsmB-F 191 kdgffiak 198 gff+a sp|Q63ZY6|NSN5C_HUMAN 230 SGGFFVAV 237 *****996 PP >> sp|Q63ZY6-6|NSN5C_HUMAN Isoform 5 of Putative methyltransferase NSUN5C OS=Homo sapiens GN=NSUN5P2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 31.1 0.0 4.4e-10 8.6e-07 22 98 .. 56 133 .. 35 136 .. 0.87 2 ! 21.8 0.0 3e-07 0.00057 134 198 .. 146 213 .. 141 215 .. 0.74 Alignments for each domain: == domain 1 score: 31.1 bits; conditional E-value: 4.4e-10 HHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE--CCGGGTTT- CS Methyltr_RsmB-F 22 KTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDaPCsgtgvirrd 98 KT+h+a+l+kn+g+++A d +++Rl ++a+ l gv + e D ++ + + +LlD Csg g+ +r+ sp|Q63ZY6-6|NSN5C_HUMAN 56 KTSHLAALLKNQGKIFAFDLDARRLASMATLLAWAGVSCCELAEEDFLAVSPLDPRyREVHYVLLDPSCSGSGMPSRQ 133 9*************************************99******8777544333488**************98876 PP == domain 2 score: 21.8 bits; conditional E-value: 3e-07 EEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BSTTSTT..SSECEECT-EEE-TTTTS.-SEEEEE CS Methyltr_RsmB-F 134 lvYsTCsvlveEneevieeaLkkredv.elvet.elsepkg..lklgeeagtlrllPhtenkdgffiak 198 lvYs Cs+ eEne ++++aL++++ + +l + ++ +g + g e+ lr P+t gff+a sp|Q63ZY6-6|NSN5C_HUMAN 146 LVYSMCSLCQEENEDMVQDALQQNPGAfRLAPAlPARPHRGlsTFPGAEH-CLRASPKTTLSGGFFVAV 213 9**********************986427766513333333103345555.8999***********996 PP >> sp|Q8NE18-2|NSUN7_HUMAN Isoform 2 of Putative methyltransferase NSUN7 OS=Homo sapiens GN=NSUN7 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 35.4 0.5 2.1e-11 4e-08 24 156 .. 308 456 .. 293 462 .. 0.77 Alignments for each domain: == domain 1 score: 35.4 bits; conditional E-value: 2.1e-11 HHHHHH.TTTTSEEEEEESSCC.CHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE--CCGGG.......TTT-T CS Methyltr_RsmB-F 24 thiael.mknkgtvvAvdanke.RlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDaPCsgtgv.......irrdp 99 +h++ l ++n+++v+ ++++ + +++ +++g++n+ +l+ +i++ +++ iLl Csg+gv ++ ++ sp|Q8NE18-2|NSUN7_HUMAN 308 SHMSILtNNNTSKVFVCGVQSQaKDPDLKTLFTKIGCKNIEILHEKFINIESKDHRlQKVKVILLLPRCSGLGVsnpvefiLNEHE 393 67777755667777766655541566899999************999888766555588999999999*****7444444367889 PP THHHH.-CCH.......HCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH CS Methyltr_RsmB-F 100 dvklrrkekd.......iaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkk 156 d ++++ ++ + la++q e l+ a++ +k++ +vY+TCsv +eEne+v+++aL+ sp|Q8NE18-2|NSUN7_HUMAN 394 DTEFLKDHSQggisvdkLHVLAQQQYEQLTHAMKFTKAQ-AVVYCTCSVFPEENEAVVKKALEF 456 998888765322221125667888999999999999987.689******************975 PP >> sp|Q8NE18|NSUN7_HUMAN Putative methyltransferase NSUN7 OS=Homo sapiens GN=NSUN7 PE=2 SV=4 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 34.3 0.4 4.4e-11 8.4e-08 24 156 .. 308 456 .. 293 461 .. 0.76 Alignments for each domain: == domain 1 score: 34.3 bits; conditional E-value: 4.4e-11 HHHHHH.TTTTSEEEEEESSCC.CHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE--CCGGG.......TTT-TTH CS Methyltr_RsmB-F 24 thiael.mknkgtvvAvdanke.RlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDaPCsgtgv.......irrdpdv 101 +h++ l ++n+++v+ ++++ + +++ +++g++n+ +l+ +i++ +++ iLl Csg+gv ++ ++d sp|Q8NE18|NSUN7_HUMAN 308 SHMSILtNNNTSKVFVCGVQSQaKDPDLKTLFTKIGCKNIEILHEKFINIESKDHRlQKVKVILLLPRCSGLGVsnpvefiLNEHEDT 395 67777755667777766655541566899999************999888766555588999999999*****744444436788999 PP HHH.-CCH.......HCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH CS Methyltr_RsmB-F 102 klrrkekd.......iaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkk 156 ++++ ++ + la++q e l+ a++ +k++ +vY+TCsv +eEne+v+++aL+ sp|Q8NE18|NSUN7_HUMAN 396 EFLKDHSQggisvdkLHVLAQQQYEQLTHAMKFTKAQ-AVVYCTCSVFPEENEAVVKKALEF 456 8888765322221125667888999999999999987.689******************975 PP >> sp|Q63ZY6-2|NSN5C_HUMAN Isoform 2 of Putative methyltransferase NSUN5C OS=Homo sapiens GN=NSUN5P2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 33.5 0.0 8.2e-11 1.6e-07 22 98 .. 56 133 .. 35 135 .] 0.86 Alignments for each domain: == domain 1 score: 33.5 bits; conditional E-value: 8.2e-11 HHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE--CCGGGTTT- CS Methyltr_RsmB-F 22 KTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDaPCsgtgvirrd 98 KT+h+a+l+kn+g+++A d +++Rl ++a+ l gv + e D ++ + + +LlD Csg g + r+ sp|Q63ZY6-2|NSN5C_HUMAN 56 KTSHLAALLKNQGKIFAFDLDARRLASMATLLAWAGVSCCELAEEDFLAVSPLDPRyREVHYVLLDPSCSGSGEMVRR 133 9*************************************99******8777544333488*************987776 PP >> sp|Q96P11-3|NSUN5_HUMAN Isoform 3 of Putative methyltransferase NSUN5 OS=Homo sapiens GN=NSUN5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 32.3 0.1 1.8e-10 3.5e-07 1 35 [. 162 196 .. 162 199 .. 0.95 Alignments for each domain: == domain 1 score: 32.3 bits; conditional E-value: 1.8e-10 HHHH---TT-EEEECS-TT-HHHHHHHHHTTTTSE CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKTthiaelmknkgt 35 a+lL+p ++ +++D+caaPG KT+h+a+l+kn+g sp|Q96P11-3|NSUN5_HUMAN 162 AMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGS 196 689*****************************996 PP >> tr|F5GYR3|F5GYR3_HUMAN Putative ribosomal RNA methyltransferase NOP2 (Fragment) OS=Homo sapiens GN=NOP2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 29.8 0.1 1.1e-09 2e-06 1 23 [. 253 275 .] 253 275 .] 0.96 Alignments for each domain: == domain 1 score: 29.8 bits; conditional E-value: 1.1e-09 HHHH---TT-EEEECS-TT-HHH CS Methyltr_RsmB-F 1 allLapqeeetilDlcaaPGgKT 23 +++Lapqe+e+ilD+c+aPGgKT tr|F5GYR3|F5GYR3_HUMAN 253 VMALAPQEHERILDMCCAPGGKT 275 589*******************9 PP >> sp|Q3KNT7|NSN5B_HUMAN Putative NOL1/NOP2/Sun domain family member 5B OS=Homo sapiens GN=NSUN5P1 PE=5 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 29.3 0.0 1.6e-09 3e-06 80 198 .. 33 155 .. 8 157 .. 0.73 Alignments for each domain: == domain 1 score: 29.3 bits; conditional E-value: 1.6e-09 EEEEEEEE--CCGGGTTT-TTHHHH.-..CCHHCCHHHHHHHHHHHHHHHEEEEEEEEEEES---CTCTHHHHHHHHHH-TTE.EEES CS Methyltr_RsmB-F 80 fDriLlDaPCsgtgvirrdpdvklrrk..ekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredv.elve 164 + +LlD Csg g+ +r+ + + + + +la q++ l a++ + lvYs Cs+ eEne ++ +aL++++ + +l + sp|Q3KNT7|NSN5B_HUMAN 33 VHYVLLDPSCSGSGMPSRQLEDPGAGTpsPVRLHALAGFQQRALCHALTF-PSLQRLVYSMCSLCQEENEDMVPDALQQNPGAfRLAP 119 6679*************987766655500556678888877777666544.34447**********************9986427766 PP S.BSTTSTT..SSECEECT-EEE-TTTTS.-SEEEEE CS Methyltr_RsmB-F 165 t.elsepkg..lklgeeagtlrllPhtenkdgffiak 198 ++ +g + g e+ lr P+t gff+a sp|Q3KNT7|NSN5B_HUMAN 120 AlPARPHRGlsTFPGAEH-CLRASPKTTLSGGFFVAV 155 513333333103345555.899************996 PP >> sp|Q63ZY6-4|NSN5C_HUMAN Isoform 3 of Putative methyltransferase NSUN5C OS=Homo sapiens GN=NSUN5P2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.1 0.0 3e-08 5.8e-05 133 198 .. 41 109 .. 19 111 .. 0.76 Alignments for each domain: == domain 1 score: 25.1 bits; conditional E-value: 3e-08 EEEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BSTTSTT..SSECEECT-EEE-TTTTS.-SEEEEE CS Methyltr_RsmB-F 133 vlvYsTCsvlveEneevieeaLkkredv.elvet.elsepkg..lklgeeagtlrllPhtenkdgffiak 198 lvYs Cs+ eEne ++++aL++++ + +l + ++ +g + g e+ lr P+t gff+a sp|Q63ZY6-4|NSN5C_HUMAN 41 RLVYSMCSLCQEENEDMVQDALQQNPGAfRLAPAlPARPHRGlsTFPGAEH-CLRASPKTTLSGGFFVAV 109 59**********************986427766513333333103345555.89*************996 PP >> sp|P0C7V9|ME15P_HUMAN Putative methyltransferase-like protein 15P1 OS=Homo sapiens GN=METTL15P1 PE=5 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.0 0.0 6.4e-08 0.00012 2 92 .. 82 175 .. 81 192 .. 0.91 Alignments for each domain: == domain 1 score: 24.0 bits; conditional E-value: 6.4e-08 HHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.....--EEEEE CS Methyltr_RsmB-F 2 llLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.....elfDriL 84 +L pq+++ +lD+ + Gg T i++ ++ +++A+d++ + + ++ae l+ L +++ + + ++ + l + +fD +L sp|P0C7V9|ME15P_HUMAN 82 HCLSPQKGQIFLDMTFGSGGHTKAILQK-ESDIVLYALDRDPT-AYALAEHLSELYPKQIRAMLGQFSQAEALLMKagvqpGTFDGVL 167 579***********************98.888999*****998.6789**********************9999888898889***** PP EEE--CCG CS Methyltr_RsmB-F 85 lDaPCsgt 92 +D Cs++ sp|P0C7V9|ME15P_HUMAN 168 MDLGCSSM 175 ******86 PP >> sp|A6NJ78-2|MET15_HUMAN Isoform 2 of Probable methyltransferase-like protein 15 OS=Homo sapiens GN=METTL15 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 23.6 0.0 8.8e-08 0.00017 2 92 .. 82 175 .. 81 190 .. 0.90 Alignments for each domain: == domain 1 score: 23.6 bits; conditional E-value: 8.8e-08 HHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.....--EEE CS Methyltr_RsmB-F 2 llLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.....elfDr 82 +L pq+++ +lD+ + Gg T i++ ++ +++A+d++ + + ++ae l+ L +++ + + ++ + l + +fD sp|A6NJ78-2|MET15_HUMAN 82 HCLSPQKGQIFLDMTFGSGGHTKAILQK-ESDIVLYALDRDPT-AYALAEHLSELYPKQIRAMLGQFSQAEALLMKagvqpGTFDG 165 579***********************98.888999*****998.6789**********************9999888898889*** PP EEEEE--CCG CS Methyltr_RsmB-F 83 iLlDaPCsgt 92 +L+D Cs++ sp|A6NJ78-2|MET15_HUMAN 166 VLMDLGCSSM 175 ********86 PP >> sp|A6NJ78-4|MET15_HUMAN Isoform 4 of Probable methyltransferase-like protein 15 OS=Homo sapiens GN=METTL15 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 23.5 0.0 9.3e-08 0.00018 2 92 .. 82 175 .. 81 190 .. 0.90 Alignments for each domain: == domain 1 score: 23.5 bits; conditional E-value: 9.3e-08 HHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.....--EEE CS Methyltr_RsmB-F 2 llLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.....elfDr 82 +L pq+++ +lD+ + Gg T i++ ++ +++A+d++ + + ++ae l+ L +++ + + ++ + l + +fD sp|A6NJ78-4|MET15_HUMAN 82 HCLSPQKGQIFLDMTFGSGGHTKAILQK-ESDIVLYALDRDPT-AYALAEHLSELYPKQIRAMLGQFSQAEALLMKagvqpGTFDG 165 579***********************98.888999*****998.6789**********************9999888898889*** PP EEEEE--CCG CS Methyltr_RsmB-F 83 iLlDaPCsgt 92 +L+D Cs++ sp|A6NJ78-4|MET15_HUMAN 166 VLMDLGCSSM 175 ********86 PP >> sp|A6NJ78|MET15_HUMAN Probable methyltransferase-like protein 15 OS=Homo sapiens GN=METTL15 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.4 0.0 2e-07 0.00038 2 92 .. 82 175 .. 81 189 .. 0.91 Alignments for each domain: == domain 1 score: 22.4 bits; conditional E-value: 2e-07 HHH---TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.....--EEEEE CS Methyltr_RsmB-F 2 llLapqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.....elfDriL 84 +L pq+++ +lD+ + Gg T i++ ++ +++A+d++ + + ++ae l+ L +++ + + ++ + l + +fD +L sp|A6NJ78|MET15_HUMAN 82 HCLSPQKGQIFLDMTFGSGGHTKAILQK-ESDIVLYALDRDPT-AYALAEHLSELYPKQIRAMLGQFSQAEALLMKagvqpGTFDGVL 167 579***********************98.888999*****998.6789**********************9999888898889***** PP EEE--CCG CS Methyltr_RsmB-F 85 lDaPCsgt 92 +D Cs++ sp|A6NJ78|MET15_HUMAN 168 MDLGCSSM 175 ******86 PP >> sp|Q3KNT7-2|NSN5B_HUMAN Isoform 2 of Putative NOL1/NOP2/Sun domain family member 5B OS=Homo sapiens GN=NSUN5P1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.8 0.0 1.5e-07 0.00028 133 198 .. 41 109 .. 19 111 .. 0.76 Alignments for each domain: == domain 1 score: 22.8 bits; conditional E-value: 1.5e-07 EEEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BSTTSTT..SSECEECT-EEE-TTTTS.-SEEEEE CS Methyltr_RsmB-F 133 vlvYsTCsvlveEneevieeaLkkredv.elvet.elsepkg..lklgeeagtlrllPhtenkdgffiak 198 lvYs Cs+ eEne ++ +aL++++ + +l + ++ +g + g e+ lr P+t gff+a sp|Q3KNT7-2|NSN5B_HUMAN 41 RLVYSMCSLCQEENEDMVPDALQQNPGAfRLAPAlPARPHRGlsTFPGAEH-CLRASPKTTLSGGFFVAV 109 59*********************9986427766513333333103345555.89*************996 PP >> sp|Q3KNT7-3|NSN5B_HUMAN Isoform 3 of Putative NOL1/NOP2/Sun domain family member 5B OS=Homo sapiens GN=NSUN5P1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.7 0.0 3.2e-07 0.00061 133 198 .. 41 109 .. 20 111 .. 0.76 Alignments for each domain: == domain 1 score: 21.7 bits; conditional E-value: 3.2e-07 EEEEEES---CTCTHHHHHHHHHH-TTE.EEESS.BSTTSTT..SSECEECT-EEE-TTTTS.-SEEEEE CS Methyltr_RsmB-F 133 vlvYsTCsvlveEneevieeaLkkredv.elvet.elsepkg..lklgeeagtlrllPhtenkdgffiak 198 lvYs Cs+ eEne ++ +aL++++ + +l + ++ +g + g e+ lr P+t gff+a sp|Q3KNT7-3|NSN5B_HUMAN 41 RLVYSMCSLCQEENEDMVPDALQQNPGAfRLAPAlPARPHRGlsTFPGAEH-CLRASPKTTLSGGFFVAV 109 59*********************9986427766513333333103345555.899************996 PP >> tr|J3QSE2|J3QSE2_HUMAN pre-rRNA-processing protein FTSJ3 (Fragment) OS=Homo sapiens GN=FTSJ3 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.1 0.0 7e-05 0.13 8 41 .. 44 77 .. 40 111 .. 0.88 Alignments for each domain: == domain 1 score: 14.1 bits; conditional E-value: 7e-05 TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEES CS Methyltr_RsmB-F 8 eeetilDlcaaPGgKTthiaelmknkgtvvAvda 41 + +lDlcaaPGg a++m ++ +v vd tr|J3QSE2|J3QSE2_HUMAN 44 KARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDL 77 55679************99*99999999999985 PP >> tr|J3KS36|J3KS36_HUMAN pre-rRNA-processing protein FTSJ3 (Fragment) OS=Homo sapiens GN=FTSJ3 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.4 0.0 0.00011 0.21 8 41 .. 44 77 .. 40 117 .. 0.86 Alignments for each domain: == domain 1 score: 13.4 bits; conditional E-value: 0.00011 TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEES CS Methyltr_RsmB-F 8 eeetilDlcaaPGgKTthiaelmknkgtvvAvda 41 + +lDlcaaPGg a++m ++ +v vd tr|J3KS36|J3KS36_HUMAN 44 KARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDL 77 55679************99999999999999985 PP >> sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member 1 OS=Homo sapiens GN=HEMK1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.0 0.0 0.00015 0.29 12 75 .. 163 226 .. 158 236 .. 0.85 Alignments for each domain: == domain 1 score: 13.0 bits; conditional E-value: 0.00015 EEECS-TT-HHH.HHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--.SEEEEES-CCCCHHHH CS Methyltr_RsmB-F 12 ilDlcaaPGgKT.thiaelmknkgtvvAvdankeRlkrvaenlkrLgvt.ntivleaDarkidkvl 75 il++ ++ G+ +++++l ++++v+Avd+ + ++ +en +rL ++ + +++ D++ +++ sp|Q9Y5R4|HEMK1_HUMAN 163 ILEVGCGSGAISlSLLSQL--PQSRVIAVDKREAAISLTHENAQRLRLQdRIWIIHLDMTSERSWT 226 6777777777542677788..999************************9668899****9887775 PP >> tr|M0R299|M0R299_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.5 0.0 0.00021 0.4 7 87 .. 73 152 .. 68 162 .. 0.78 Alignments for each domain: == domain 1 score: 12.5 bits; conditional E-value: 0.00021 -TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE CS Methyltr_RsmB-F 7 qeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDa 87 +++ ++l l aa G +h+++++ + g v+Av+ +++ + ++ nl + tn+i + Dar+++k+ +++D i D+ tr|M0R299|M0R299_HUMAN 73 KPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLI-NLAKK-RTNIIPVIEDARHPHKYRMLiAMVDVIFADV 152 56778999**************************9866555554.44443.3457788899999999866547788777775 PP >> sp|O00273-2|DFFA_HUMAN Isoform DFF35 of DNA fragmentation factor subunit alpha OS=Homo sapiens GN=DFFA # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.8 0.1 0.00018 0.34 82 135 .. 147 206 .. 116 240 .. 0.79 Alignments for each domain: == domain 1 score: 12.8 bits; conditional E-value: 0.00018 EEEEEE--CCGGGTTT-TTHHHH.-CCHHCCHHHHH......HHHHHHHHHHEEEEEEEE CS Methyltr_RsmB-F 82 riLlDaPCsgtgvirrdpdvklrrkekdiaqlaklq......kellsaaidllkkgGvlv 135 ++L+DaPCs + r+ + ++r +++++q+ ++ k+ll+ ++ l k+G l+ sp|O00273-2|DFFA_HUMAN 147 QMLVDAPCSDLAQELRQSCATVQRLQHTLQQVLDQReevrqsKQLLQLYLQALEKEGSLL 206 78***********99999999999999999886543122222788999999998888886 PP >> tr|M0QXL5|M0QXL5_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.2 0.0 0.00026 0.5 7 86 .. 96 174 .. 91 180 .. 0.78 Alignments for each domain: == domain 1 score: 12.2 bits; conditional E-value: 0.00026 -TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEE CS Methyltr_RsmB-F 7 qeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlD 86 +++ ++l l aa G +h+++++ + g v+Av+ +++ + ++ nl + tn+i + Dar+++k+ +++D i D tr|M0QXL5|M0QXL5_HUMAN 96 KPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLI-NLAKK-RTNIIPVIEDARHPHKYRMLiAMVDVIFAD 174 56778999**************************9866555554.44443.345778889999999986654677877776 PP >> tr|M0R0P1|M0R0P1_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.5 0.0 0.00021 0.4 7 87 .. 121 200 .. 116 210 .. 0.78 Alignments for each domain: == domain 1 score: 12.5 bits; conditional E-value: 0.00021 -TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE CS Methyltr_RsmB-F 7 qeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDa 87 +++ ++l l aa G +h+++++ + g v+Av+ +++ + ++ nl + tn+i + Dar+++k+ +++D i D+ tr|M0R0P1|M0R0P1_HUMAN 121 KPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLI-NLAKK-RTNIIPVIEDARHPHKYRMLiAMVDVIFADV 200 56778999**************************9866555554.44443.3457788899999999866547788777775 PP >> tr|M0R2Q4|M0R2Q4_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Fragment) OS=Homo sapiens GN=FBL PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.1 0.0 0.00029 0.55 7 87 .. 134 213 .. 129 228 .. 0.79 Alignments for each domain: == domain 1 score: 12.1 bits; conditional E-value: 0.00029 -TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE CS Methyltr_RsmB-F 7 qeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDa 87 +++ ++l l aa G +h+++++ + g v+Av+ +++ + ++ nl + tn+i + Dar+++k+ +++D i D+ tr|M0R2Q4|M0R2Q4_HUMAN 134 KPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLI-NLAKK-RTNIIPVIEDARHPHKYRMLiAMVDVIFADV 213 567789999*************************9866555554.44443.3457788899999999866547788777775 PP >> sp|P22087|FBRL_HUMAN rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens GN=FBL PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.7 0.0 0.00037 0.71 7 87 .. 158 237 .. 153 262 .. 0.81 Alignments for each domain: == domain 1 score: 11.7 bits; conditional E-value: 0.00037 -TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEEE CS Methyltr_RsmB-F 7 qeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlDa 87 +++ ++l l aa G +h+++++ + g v+Av+ +++ + ++ nl + tn+i + Dar+++k+ +++D i D+ sp|P22087|FBRL_HUMAN 158 KPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLI-NLAKK-RTNIIPVIEDARHPHKYRMLiAMVDVIFADV 237 567789999*************************9866555554.44443.3457788899999999866547788777775 PP >> sp|Q9HBK9|AS3MT_HUMAN Arsenite methyltransferase OS=Homo sapiens GN=AS3MT PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 4.3 0.0 0.07 1.4e+02 8 46 .. 70 108 .. 64 126 .. 0.88 2 ? 5.4 0.0 0.032 61 110 138 .. 157 185 .. 136 199 .. 0.82 Alignments for each domain: == domain 1 score: 4.3 bits; conditional E-value: 0.07 TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCH CS Methyltr_RsmB-F 8 eeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRl 46 e+ +ilDl ++ G +++l+ +kg+v+ +d+ k + sp|Q9HBK9|AS3MT_HUMAN 70 ENCWILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTKGQV 108 6778*****************************988665 PP == domain 2 score: 5.4 bits; conditional E-value: 0.032 HCCHHHHHHHHHHHHHHHEEEEEEEEEEE CS Methyltr_RsmB-F 110 iaqlaklqkellsaaidllkkgGvlvYsT 138 +++l+ ++++l+ a +lk+gG l +s sp|Q9HBK9|AS3MT_HUMAN 157 VINLVPDKQQVLQEAYRVLKHGGELYFSD 185 67888999*****************9885 PP >> tr|R4GMW7|R4GMW7_HUMAN rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 OS=Homo sapiens GN=FBLL1 PE=3 SV= # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.2 0.0 0.00054 1 7 86 .. 170 248 .. 165 263 .. 0.76 Alignments for each domain: == domain 1 score: 11.2 bits; conditional E-value: 0.00054 -TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEE CS Methyltr_RsmB-F 7 qeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlD 86 +++ ++l l aa G +h+++++ + g v+Av+ ++ R+ r n+ + tn+i + Dar++ k+ ++D i D tr|R4GMW7|R4GMW7_HUMAN 170 KPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFSH-RAGRDLVNVAKKR-TNIIPVLEDARHPLKYRMLiGMVDVIFAD 248 56778999**************************975.5555445555433.45778888999887664332456666655 PP >> sp|A6NHQ2|FBLL1_HUMAN rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 OS=Homo sapiens GN=FBLL1 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.2 0.0 0.00054 1 7 86 .. 170 248 .. 165 261 .. 0.75 Alignments for each domain: == domain 1 score: 11.2 bits; conditional E-value: 0.00054 -TT-EEEECS-TT-HHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CCCCHHHHCC.--EEEEEEE CS Methyltr_RsmB-F 7 qeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDarkidkvlgg.elfDriLlD 86 +++ ++l l aa G +h+++++ + g v+Av+ ++ R+ r n+ + tn+i + Dar++ k+ ++D i D sp|A6NHQ2|FBLL1_HUMAN 170 KPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFSH-RAGRDLVNVAKKR-TNIIPVLEDARHPLKYRMLiGMVDVIFAD 248 56778999**************************975.5555445555433.45778888999887664332456666555 PP >> sp|Q9UET6-2|TRM7_HUMAN Isoform 2 of Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapien # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 9.5 0.0 0.0019 3.6 12 43 .. 45 78 .. 39 116 .. 0.78 2 ? -0.7 0.0 2.4 4.6e+03 109 135 .. 126 154 .. 107 155 .. 0.67 Alignments for each domain: == domain 1 score: 9.5 bits; conditional E-value: 0.0019 EEECS-TT-HHHHHHHHH..TTTTSEEEEEESSC CS Methyltr_RsmB-F 12 ilDlcaaPGgKTthiael..mknkgtvvAvdank 43 +DlcaaPG+ +++ + +g+vvAvd ++ sp|Q9UET6-2|TRM7_HUMAN 45 AVDLCAAPGSWSQVLSQKigGQGSGHVVAVDLQA 78 68*************99834456689****9876 PP == domain 2 score: -0.7 bits; conditional E-value: 2.4 HHCCHHHHHHHH..HHHHHHHEEEEEEEE CS Methyltr_RsmB-F 109 diaqlaklqkel..lsaaidllkkgGvlv 135 d+ ++++ q l l++a ++lk+gG v sp|Q9UET6-2|TRM7_HUMAN 126 DVDEYMQAQLLLaaLNIATHVLKPGGCFV 154 4555544443332277788888***9876 PP >> sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens GN=FTSJ1 PE=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 9.4 0.0 0.0019 3.6 12 43 .. 45 78 .. 39 116 .. 0.78 2 ? -0.7 0.0 2.4 4.7e+03 109 135 .. 126 154 .. 107 155 .. 0.67 Alignments for each domain: == domain 1 score: 9.4 bits; conditional E-value: 0.0019 EEECS-TT-HHHHHHHHH..TTTTSEEEEEESSC CS Methyltr_RsmB-F 12 ilDlcaaPGgKTthiael..mknkgtvvAvdank 43 +DlcaaPG+ +++ + +g+vvAvd ++ sp|Q9UET6|TRM7_HUMAN 45 AVDLCAAPGSWSQVLSQKigGQGSGHVVAVDLQA 78 68*************99834456689****9876 PP == domain 2 score: -0.7 bits; conditional E-value: 2.4 HHCCHHHHHHHH..HHHHHHHEEEEEEEE CS Methyltr_RsmB-F 109 diaqlaklqkel..lsaaidllkkgGvlv 135 d+ ++++ q l l++a ++lk+gG v sp|Q9UET6|TRM7_HUMAN 126 DVDEYMQAQLLLaaLNIATHVLKPGGCFV 154 4555544443332277788888***9876 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (200 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 2754 (0.0311281); expected 1769.5 (0.02) Passed bias filter: 1952 (0.0220632); expected 1769.5 (0.02) Passed Vit filter: 196 (0.00221537); expected 88.5 (0.001) Passed Fwd filter: 46 (0.000519933); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 46 [number of targets reported over threshold] # CPU time: 0.61u 0.03s 00:00:00.64 Elapsed: 00:00:00.24 # Mc/sec: 29225.43 // [ok]