# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_10.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_10 [M=299] Accession: PF05971.11 Description: Protein of unknown function (DUF890) Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 2.3e-136 456.3 0.0 3e-136 455.9 0.0 1.1 1 sp|Q86W50|MET16_HUMAN Methyltransferase-like protein 16 OS 2.7e-97 328.0 0.0 3.2e-97 327.8 0.0 1.0 1 sp|Q86W50-2|MET16_HUMAN Isoform 2 of Methyltransferase-like 3e-75 255.6 0.0 3.4e-75 255.4 0.0 1.0 1 tr|I3L362|I3L362_HUMAN Methyltransferase-like protein 16 OS 6.7e-61 208.5 0.9 8e-48 165.6 0.1 2.0 2 tr|I3L4V1|I3L4V1_HUMAN Methyltransferase-like protein 16 (F 4.5e-49 169.7 0.0 5.2e-49 169.5 0.0 1.0 1 tr|I3L3W3|I3L3W3_HUMAN Methyltransferase-like protein 16 OS 1.2e-29 105.9 0.1 1.7e-29 105.4 0.1 1.2 1 tr|B7Z3X7|B7Z3X7_HUMAN Methyltransferase-like protein 16 OS 4.9e-28 100.6 0.0 5.7e-28 100.4 0.0 1.0 1 tr|K7EKQ8|K7EKQ8_HUMAN Methyltransferase-like protein 16 (F ------ inclusion threshold ------ 0.42 12.2 0.0 0.69 11.5 0.0 1.2 1 sp|Q8NEM2|SHCBP_HUMAN SHC SH2 domain-binding protein 1 OS= 0.76 11.3 0.0 1 10.9 0.0 1.1 1 tr|Q5JSB6|Q5JSB6_HUMAN Transcription factor Dp-1 (Fragment) Domain annotation for each sequence (and alignments): >> sp|Q86W50|MET16_HUMAN Methyltransferase-like protein 16 OS=Homo sapiens GN=METTL16 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 455.9 0.0 3.1e-140 3e-136 1 299 [] 1 291 [. 1 291 [. 0.99 Alignments for each domain: == domain 1 score: 455.9 bits; conditional E-value: 3.1e-140 XXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXS-TTSHHHHHHHHHHHHHHHH----.---TTS----HHHHHHHHH CS Methyltransf_10 1 aalksglhprnrhkdky.dfaalikvvPelkqfvilnpkGrvsidfadPlavkalnkallrefygvsewdiPdgfliPpvPgradyih 87 +al++++h+rnr+kdk+ dfa+l++++P++kq+v++n++Grvs++f+dP+av+al+++llre++g+s+ diP ++liP+vP+r++yih sp|Q86W50|MET16_HUMAN 1 MALSKSMHARNRYKDKPpDFAYLASKYPDFKQHVQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSI-DIPLERLIPTVPLRLNYIH 87 6899************99**************************************************.******************* PP HHHHHHT--TCGCS---EEEEES-TTTTHHHHHHHHHH--EEEEEES-HHHHHHHHHHHHHT.T-TTTEEEEE--ST-SSTTTSTT-- CS Methyltransf_10 88 yvadllgkadsdisaqvraldiGvGanCiyPllGvteyGWrfvgsevddvslasakaivesnsklsdaiklrkqkekkaifdglieen 175 +v+dl+g++dsd+s+ +r++diG+Ga+CiyPllG+t++GW+f+++evdd+++++ak++ve+n +lsd+ik++k+++k+ ++d+l+ee+ sp|Q86W50|MET16_HUMAN 88 WVEDLIGHQDSDKSTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQN-NLSDLIKVVKVPQKTLLMDALKEES 174 **************************************************************.************************* PP S.-EEEEEE-----SS------------...---.....---------TTTTHHHHTHHHHHHHHHHHHHHHGGGEEEEEEEESSGGG CS Methyltransf_10 176 e.rydvtlCnPPfhaslaeakagserklknlgkanktralpslnfgGqkaelyceGGevafikklieeskqlakqvlWfttlvskken 262 e +yd+++CnPPf+a+++eak++++r++ +++ +ps++++G+++e+++eGGe++f+k++i++s ql+k+++W++++++kk++ sp|Q86W50|MET16_HUMAN 175 EiIYDFCMCNPPFFANQLEAKGVNSRNP---RRP-----PPSSVNTGGITEIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCS 254 *99*************************...776.....899********************************************** PP HHHHHHHHHHTT-SEEEEEEEEETTEEEEEEEEES-- CS Methyltransf_10 263 laplkeelkklGaskvtvvelaqGqklsrfiaWsfld 299 laplkeel+++G++kvt++e++qG+++++++aWsf+d sp|Q86W50|MET16_HUMAN 255 LAPLKEELRIQGVPKVTYTEFCQGRTMRWALAWSFYD 291 ***********************************97 PP >> sp|Q86W50-2|MET16_HUMAN Isoform 2 of Methyltransferase-like protein 16 OS=Homo sapiens GN=METTL16 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 327.8 0.0 3.2e-101 3.2e-97 1 222 [. 1 214 [. 1 218 [. 0.96 Alignments for each domain: == domain 1 score: 327.8 bits; conditional E-value: 3.2e-101 XXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXS-TTSHHHHHHHHHHHHHHHH----.---TTS----HHHHHHH CS Methyltransf_10 1 aalksglhprnrhkdky.dfaalikvvPelkqfvilnpkGrvsidfadPlavkalnkallrefygvsewdiPdgfliPpvPgrady 85 +al++++h+rnr+kdk+ dfa+l++++P++kq+v++n++Grvs++f+dP+av+al+++llre++g+s+ diP ++liP+vP+r++y sp|Q86W50-2|MET16_HUMAN 1 MALSKSMHARNRYKDKPpDFAYLASKYPDFKQHVQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSI-DIPLERLIPTVPLRLNY 85 6899************99**************************************************.***************** PP HHHHHHHHT--TCGCS---EEEEES-TTTTHHHHHHHHHH--EEEEEES-HHHHHHHHHHHHHT.T-TTTEEEEE--ST-SSTTTS CS Methyltransf_10 86 ihyvadllgkadsdisaqvraldiGvGanCiyPllGvteyGWrfvgsevddvslasakaivesnsklsdaiklrkqkekkaifdgl 171 ih+v+dl+g++dsd+s+ +r++diG+Ga+CiyPllG+t++GW+f+++evdd+++++ak++ve+n +lsd+ik++k+++k+ ++d+l sp|Q86W50-2|MET16_HUMAN 86 IHWVEDLIGHQDSDKSTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQN-NLSDLIKVVKVPQKTLLMDAL 170 ****************************************************************.********************* PP TT--S.-EEEEEE-----SS------------...---.....--------- CS Methyltransf_10 172 ieene.rydvtlCnPPfhaslaeakagserklknlgkanktralpslnfgGq 222 +ee+e +yd+++CnPPf+a+++eak++++r++ +++ +ps++++G+ sp|Q86W50-2|MET16_HUMAN 171 KEESEiIYDFCMCNPPFFANQLEAKGVNSRNP---RRP-----PPSSVNTGD 214 *****99************************9...555.....566666665 PP >> tr|I3L362|I3L362_HUMAN Methyltransferase-like protein 16 OS=Homo sapiens GN=METTL16 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 255.4 0.0 3.5e-79 3.4e-75 1 164 [. 1 163 [. 1 167 [. 0.97 Alignments for each domain: == domain 1 score: 255.4 bits; conditional E-value: 3.5e-79 XXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXS-TTSHHHHHHHHHHHHHHHH----.---TTS----HHHHHHHH CS Methyltransf_10 1 aalksglhprnrhkdky.dfaalikvvPelkqfvilnpkGrvsidfadPlavkalnkallrefygvsewdiPdgfliPpvPgradyi 86 +al++++h+rnr+kdk+ dfa+l++++P++kq+v++n++Grvs++f+dP+av+al+++llre++g+s+ diP ++liP+vP+r++yi tr|I3L362|I3L362_HUMAN 1 MALSKSMHARNRYKDKPpDFAYLASKYPDFKQHVQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSI-DIPLERLIPTVPLRLNYI 86 6899************99**************************************************.****************** PP HHHHHHHT--TCGCS---EEEEES-TTTTHHHHHHHHHH--EEEEEES-HHHHHHHHHHHHHT.T-TTTEEEEE--ST CS Methyltransf_10 87 hyvadllgkadsdisaqvraldiGvGanCiyPllGvteyGWrfvgsevddvslasakaivesnsklsdaiklrkqkek 164 h+v+dl+g++dsd+s+ +r++diG+Ga+CiyPllG+t++GW+f+++evdd+++++ak++ve+n +lsd+ik k ++ tr|I3L362|I3L362_HUMAN 87 HWVEDLIGHQDSDKSTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQN-NLSDLIKGSKLTKS 163 ***************************************************************.******98776554 PP >> tr|I3L4V1|I3L4V1_HUMAN Methyltransferase-like protein 16 (Fragment) OS=Homo sapiens GN=METTL16 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 165.6 0.1 8.1e-52 8e-48 1 110 [. 1 110 [. 1 112 [. 0.98 2 ! 43.1 0.1 1.7e-14 1.7e-10 158 195 .. 110 148 .. 110 149 .] 0.96 Alignments for each domain: == domain 1 score: 165.6 bits; conditional E-value: 8.1e-52 XXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXS-TTSHHHHHHHHHHHHHHHH----.---TTS----HHHHHHHH CS Methyltransf_10 1 aalksglhprnrhkdky.dfaalikvvPelkqfvilnpkGrvsidfadPlavkalnkallrefygvsewdiPdgfliPpvPgradyi 86 +al++++h+rnr+kdk+ dfa+l++++P++kq+v++n++Grvs++f+dP+av+al+++llre++g+s+ diP ++liP+vP+r++yi tr|I3L4V1|I3L4V1_HUMAN 1 MALSKSMHARNRYKDKPpDFAYLASKYPDFKQHVQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSI-DIPLERLIPTVPLRLNYI 86 6899************99**************************************************.****************** PP HHHHHHHT--TCGCS---EEEEES CS Methyltransf_10 87 hyvadllgkadsdisaqvraldiG 110 h+v+dl+g++dsd+s+ +r++di tr|I3L4V1|I3L4V1_HUMAN 87 HWVEDLIGHQDSDKSTLRRGIDIV 110 **********************96 PP == domain 2 score: 43.1 bits; conditional E-value: 1.7e-14 EEE--ST-SSTTTSTT--S.-EEEEEE-----SS----- CS Methyltransf_10 158 lrkqkekkaifdglieene.rydvtlCnPPfhaslaeak 195 ++k+++k+ ++d+l+ee+e +yd+++CnPPf+a+++eak tr|I3L4V1|I3L4V1_HUMAN 110 VVKVPQKTLLMDALKEESEiIYDFCMCNPPFFANQLEAK 148 689****************99*****************8 PP >> tr|I3L3W3|I3L3W3_HUMAN Methyltransferase-like protein 16 OS=Homo sapiens GN=METTL16 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 169.5 0.0 5.3e-53 5.2e-49 1 111 [. 1 111 [. 1 114 [. 0.98 Alignments for each domain: == domain 1 score: 169.5 bits; conditional E-value: 5.3e-53 XXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXS-TTSHHHHHHHHHHHHHHHH----.---TTS----HHHHHHHH CS Methyltransf_10 1 aalksglhprnrhkdky.dfaalikvvPelkqfvilnpkGrvsidfadPlavkalnkallrefygvsewdiPdgfliPpvPgradyi 86 +al++++h+rnr+kdk+ dfa+l++++P++kq+v++n++Grvs++f+dP+av+al+++llre++g+s+ diP ++liP+vP+r++yi tr|I3L3W3|I3L3W3_HUMAN 1 MALSKSMHARNRYKDKPpDFAYLASKYPDFKQHVQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSI-DIPLERLIPTVPLRLNYI 86 6899************99**************************************************.****************** PP HHHHHHHT--TCGCS---EEEEES- CS Methyltransf_10 87 hyvadllgkadsdisaqvraldiGv 111 h+v+dl+g++dsd+s+ +r++diG tr|I3L3W3|I3L3W3_HUMAN 87 HWVEDLIGHQDSDKSTLRRGIDIGS 111 ***********************95 PP >> tr|B7Z3X7|B7Z3X7_HUMAN Methyltransferase-like protein 16 OS=Homo sapiens GN=METTL16 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 105.4 0.1 1.7e-33 1.7e-29 227 299 .] 1 73 [. 1 73 [. 0.99 Alignments for each domain: == domain 1 score: 105.4 bits; conditional E-value: 1.7e-33 HHHHTHHHHHHHHHHHHHHHGGGEEEEEEEESSGGGHHHHHHHHHHTT-SEEEEEEEEETTEEEEEEEEES-- CS Methyltransf_10 227 yceGGevafikklieeskqlakqvlWfttlvskkenlaplkeelkklGaskvtvvelaqGqklsrfiaWsfld 299 ++eGGe++f+k++i++s ql+k+++W++++++kk++laplkeel+++G++kvt++e++qG+++++++aWsf+d tr|B7Z3X7|B7Z3X7_HUMAN 1 MAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELRIQGVPKVTYTEFCQGRTMRWALAWSFYD 73 79*********************************************************************97 PP >> tr|K7EKQ8|K7EKQ8_HUMAN Methyltransferase-like protein 16 (Fragment) OS=Homo sapiens GN=METTL16 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 100.4 0.0 5.8e-32 5.7e-28 43 115 .. 2 74 .. 1 79 [. 0.94 Alignments for each domain: == domain 1 score: 100.4 bits; conditional E-value: 5.8e-32 S-TTSHHHHHHHHHHHHHHHH----.---TTS----HHHHHHHHHHHHHHHT--TCGCS---EEEEES-.TTTT CS Methyltransf_10 43 idfadPlavkalnkallrefygvsewdiPdgfliPpvPgradyihyvadllgkadsdisaqvraldiGv.GanC 115 ++f+dP+av+al+++llre++g+s+ diP ++liP+vP+r++yih+v+dl+g++dsd+s+ +r++diG+ G C tr|K7EKQ8|K7EKQ8_HUMAN 2 LNFKDPEAVRALTCTLLREDFGLSI-DIPLERLIPTVPLRLNYIHWVEDLIGHQDSDKSTLRRGIDIGIqGRAC 74 8************************.******************************************835555 PP >> sp|Q8NEM2|SHCBP_HUMAN SHC SH2 domain-binding protein 1 OS=Homo sapiens GN=SHCBP1 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.5 0.0 7e-05 0.69 166 284 .. 530 647 .. 517 653 .. 0.77 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 7e-05 SSTTTSTT--S-EEEEEE-----SS---.---------...---.....---------TTTTH.HHHTHHHHHHHHHHHHHHHGGGEE CS Methyltransf_10 166 aifdglieenerydvtlCnPPfhaslae.akagserklknlgkanktralpslnfgGqkaely.ceGGevafikklieeskqlakqvl 251 +++ +i++ne y v+l P +++l+e a+ g+e ++ l k +t+ +p + + +el+ c G +++ ++ + s+q++ + sp|Q8NEM2|SHCBP_HUMAN 530 SMVNNIIHNNEGYGVVLVKPTIFSDLQEnAEDGTEENK-AL-KI-QTSGEPDVAERVDLEELIeCATGKMELCART-DPSEQVEGNCE 613 6899****************988776552777777666.77.44.7888888888888888654999999998884.67888888888 PP EEEEEESSGGGHHHHH.HHHHHTT-SEEEEEEEE CS Methyltransf_10 252 Wfttlvskkenlaplk.eelkklGaskvtvvela 284 + l++ +++ ++k ++l +lG+++ ++ sp|Q8NEM2|SHCBP_HUMAN 614 IVNELIAASTQKGQIKkKRLSELGITQADDNLMS 647 8888888777777765256888888776655555 PP >> tr|Q5JSB6|Q5JSB6_HUMAN Transcription factor Dp-1 (Fragment) OS=Homo sapiens GN=TFDP1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.9 0.0 0.0001 1 21 77 .. 6 65 .. 3 76 .. 0.87 Alignments for each domain: == domain 1 score: 10.9 bits; conditional E-value: 0.0001 XXXXXXXXXXXXXXXXX...XXXXXS-TTSHHHHHHHHHHHHHHHH----.---TTS--- CS Methyltransf_10 21 alikvvPelkqfvilnp...kGrvsidfadPlavkalnkallrefygvsewdiPdgfliP 77 li+ + elk f+ n+ kG vs+ P +v l k ll + +g s+ +i ++ +i tr|Q5JSB6|Q5JSB6_HUMAN 6 GLIEANGELKVFIDQNLspgKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIG 65 69999********999744568999999*************************9998874 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (299 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 1728 (0.0195314); expected 1769.5 (0.02) Passed bias filter: 1408 (0.0159145); expected 1769.5 (0.02) Passed Vit filter: 103 (0.0011642); expected 88.5 (0.001) Passed Fwd filter: 9 (0.000101726); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 9 [number of targets reported over threshold] # CPU time: 0.68u 0.02s 00:00:00.70 Elapsed: 00:00:00.24 # Mc/sec: 43692.02 // [ok]