# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_11.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_11 [M=95] Accession: PF08241.11 Description: Methyltransferase domain Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 7.9e-21 76.7 0.0 1e-20 76.3 0.0 1.2 1 tr|F8VQX6|F8VQX6_HUMAN Methyltransferase-like protein 7A (F 1.2e-20 76.1 0.1 2.6e-20 75.1 0.1 1.6 1 sp|Q9NZJ6|COQ3_HUMAN Hexaprenyldihydroxybenzoate methyltr 1.5e-20 75.8 0.0 2.2e-20 75.3 0.0 1.3 1 sp|Q9H8H3|MET7A_HUMAN Methyltransferase-like protein 7A OS 1.5e-20 75.8 0.0 2.2e-20 75.3 0.0 1.3 1 tr|H0YI09|H0YI09_HUMAN Methyltransferase-like protein 7A (F 2.5e-20 75.1 0.0 3.6e-20 74.6 0.0 1.2 1 sp|Q6UX53|MET7B_HUMAN Methyltransferase-like protein 7B OS 9.6e-19 70.0 0.0 1.7e-18 69.2 0.0 1.4 1 tr|B3KR61|B3KR61_HUMAN HCG1811060, isoform CRA_c OS=Homo sa 1.5e-18 69.4 0.0 2.8e-18 68.5 0.0 1.5 1 sp|Q5TEU4|NDUF5_HUMAN NADH dehydrogenase [ubiquinone] 1 al 1.2e-17 66.5 0.3 3.2e-14 55.5 0.0 4.1 3 sp|Q8N6R0-4|MET13_HUMAN Isoform 2 of Methyltransferase-like 1.7e-17 66.1 0.3 3.6e-14 55.4 0.0 4.1 3 tr|B4E2X3|B4E2X3_HUMAN Methyltransferase-like protein 13 OS 1.7e-17 66.0 0.3 3.7e-14 55.4 0.0 4.1 3 sp|Q8N6R0|MET13_HUMAN Methyltransferase-like protein 13 OS 2.6e-17 65.4 0.0 5.8e-17 64.3 0.0 1.6 1 tr|F8VVX6|F8VVX6_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquin 4e-17 64.9 0.2 1.7e-13 53.3 0.0 4.0 3 sp|Q8N6R0-1|MET13_HUMAN Isoform 4 of Methyltransferase-like 5.5e-17 64.4 0.0 1.5e-16 63.0 0.0 1.7 1 sp|Q5HYK3|COQ5_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquin 4.4e-16 61.5 0.0 9.7e-16 60.4 0.0 1.6 1 sp|Q9P272|K1456_HUMAN Putative methyltransferase KIAA1456 1.6e-15 59.7 0.0 2.9e-15 58.9 0.0 1.5 1 sp|Q9HBK9|AS3MT_HUMAN Arsenite methyltransferase OS=Homo s 7.2e-15 57.6 0.1 1.6e-14 56.5 0.1 1.6 1 sp|Q96BT7|ALKB8_HUMAN Alkylated DNA repair protein alkB ho 7.2e-15 57.6 0.1 1.6e-14 56.5 0.1 1.6 1 sp|Q96BT7-4|ALKB8_HUMAN Isoform 4 of Alkylated DNA repair pr 3.5e-13 52.2 0.0 7.5e-13 51.2 0.0 1.6 1 sp|O60344-4|ECE2_HUMAN Isoform D of Endothelin-converting e 3.2e-12 49.1 0.0 2.1e-11 46.5 0.0 2.3 1 sp|Q6P1Q9|MET2B_HUMAN Methyltransferase-like protein 2B OS 3.5e-12 49.0 0.0 1.5e-11 47.0 0.0 1.9 1 sp|Q6P1Q9-2|MET2B_HUMAN Isoform 2 of Methyltransferase-like 3.8e-12 48.9 0.0 2e-11 46.6 0.0 2.0 1 sp|Q96IZ6-2|MET2A_HUMAN Isoform 2 of Methyltransferase-like 7.2e-12 48.0 0.0 5.2e-11 45.3 0.0 2.4 1 sp|Q96IZ6|MET2A_HUMAN Methyltransferase-like protein 2A OS 1.4e-11 47.0 0.0 3.2e-11 45.9 0.0 1.6 1 tr|B4DP72|B4DP72_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquin 1e-10 44.3 0.0 1.6e-10 43.7 0.0 1.3 1 sp|Q9BV86|NTM1A_HUMAN N-terminal Xaa-Pro-Lys N-methyltrans 2.1e-10 43.3 0.0 3.4e-10 42.7 0.0 1.3 1 sp|O43709-2|WBS22_HUMAN Isoform 2 of Uncharacterized methylt 3.3e-10 42.7 0.0 5.3e-10 42.0 0.0 1.4 1 sp|O43709|WBS22_HUMAN Uncharacterized methyltransferase WB 3.8e-10 42.5 0.0 5.9e-10 41.9 0.0 1.4 1 tr|C9K060|C9K060_HUMAN Uncharacterized methyltransferase WB 5.9e-10 41.9 0.1 1.5e-09 40.6 0.0 1.7 1 sp|Q8TCB7|METL6_HUMAN Methyltransferase-like protein 6 OS= 1.2e-09 40.9 0.1 3.9e-09 39.3 0.0 1.8 1 tr|E7ETE0|E7ETE0_HUMAN Methyltransferase-like protein 8 OS= 3.3e-09 39.5 0.0 5e-09 38.9 0.0 1.3 1 tr|H3BQF6|H3BQF6_HUMAN Uncharacterized protein (Fragment) O 5.3e-09 38.8 0.1 1.9e-05 27.4 0.0 4.1 3 sp|Q8N6R0-3|MET13_HUMAN Isoform 3 of Methyltransferase-like 7.1e-09 38.4 0.0 1.1e-08 37.8 0.0 1.3 1 sp|Q8N6F8|WBS27_HUMAN Williams-Beuren syndrome chromosomal 7.2e-09 38.4 0.0 1.2e-08 37.7 0.0 1.4 1 sp|Q5JPI9|MET10_HUMAN Methyltransferase-like protein 10 OS 2.7e-08 36.6 0.1 1e-07 34.7 0.0 1.9 1 tr|K7EP06|K7EP06_HUMAN mRNA cap guanine-N7 methyltransferas 3.1e-08 36.4 0.0 0.026 17.4 0.0 2.4 2 sp|Q7L2J0|MEPCE_HUMAN 7SK snRNA methylphosphate capping en 3.7e-08 36.1 0.0 6.4e-08 35.4 0.0 1.4 1 sp|Q14749|GNMT_HUMAN Glycine N-methyltransferase OS=Homo 3.8e-08 36.1 0.0 5.6e-08 35.5 0.0 1.3 1 sp|A8MUP2|MET12_HUMAN Methyltransferase-like protein 12, m 4.2e-08 35.9 0.1 2e-07 33.8 0.1 2.0 1 sp|O43159|RRP8_HUMAN Ribosomal RNA-processing protein 8 O 5.7e-08 35.5 0.0 9.8e-08 34.8 0.0 1.4 1 tr|H7C2P8|H7C2P8_HUMAN Methyltransferase-like protein 8 (Fr 5.9e-08 35.5 0.0 1e-07 34.7 0.0 1.3 1 tr|F8WD67|F8WD67_HUMAN Uncharacterized methyltransferase WB 8e-08 35.0 0.1 2.6e-07 33.4 0.0 1.9 1 sp|O43148|MCES_HUMAN mRNA cap guanine-N7 methyltransferas 8.5e-08 34.9 0.0 2.3e-07 33.6 0.0 1.8 1 sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS 9.4e-08 34.8 0.1 2.9e-07 33.2 0.0 1.9 1 sp|O43148-2|MCES_HUMAN Isoform 2 of mRNA cap guanine-N7 met 1.1e-07 34.6 0.0 2e-07 33.8 0.0 1.5 1 tr|F8VVW7|F8VVW7_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquin 1.1e-07 34.6 0.0 3.3e-07 33.1 0.0 1.8 1 sp|O60344|ECE2_HUMAN Endothelin-converting enzyme 2 OS=Ho 1.6e-07 34.1 0.0 3.9e-07 32.9 0.0 1.7 1 sp|O60678-2|ANM3_HUMAN Isoform 2 of Protein arginine N-meth 1.8e-07 33.9 0.0 4.7e-07 32.6 0.0 1.8 1 sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 2.1e-07 33.7 0.0 3.3e-07 33.1 0.0 1.3 1 tr|E9PNR9|E9PNR9_HUMAN Protein arginine N-methyltransferase 2.4e-07 33.5 0.0 4.6e-06 29.4 0.0 2.8 1 tr|H3BLW2|H3BLW2_HUMAN Methyltransferase-like protein 13 (F 2.6e-07 33.4 0.0 9.2e-07 31.6 0.0 1.9 1 tr|H0YDE4|H0YDE4_HUMAN Protein arginine N-methyltransferase 2.8e-07 33.3 0.0 6.4e-07 32.1 0.0 1.6 1 tr|E9PQ98|E9PQ98_HUMAN Protein arginine N-methyltransferase 3e-07 33.2 0.0 6.7e-07 32.1 0.0 1.6 1 tr|E9PIX6|E9PIX6_HUMAN Protein arginine N-methyltransferase 5.2e-07 32.4 0.0 9.9e-06 28.3 0.0 2.8 1 sp|Q8N6R0-2|MET13_HUMAN Isoform 5 of Methyltransferase-like 5.5e-07 32.3 0.1 2e-06 30.6 0.0 2.0 1 sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyl 6e-07 32.2 0.0 2e-06 30.5 0.0 1.9 1 sp|Q99873-2|ANM1_HUMAN Isoform 2 of Protein arginine N-meth 6e-07 32.2 0.0 2e-06 30.6 0.0 1.9 1 sp|Q99873-3|ANM1_HUMAN Isoform 3 of Protein arginine N-meth 6.1e-07 32.2 0.0 2.1e-06 30.5 0.0 1.9 1 sp|Q99873-4|ANM1_HUMAN Isoform 4 of Protein arginine N-meth 6.4e-07 32.1 0.0 2.2e-06 30.4 0.0 1.9 1 sp|Q99873|ANM1_HUMAN Protein arginine N-methyltransferase 6.6e-07 32.1 0.0 2.3e-06 30.4 0.0 1.9 1 tr|H7C2I1|H7C2I1_HUMAN Protein arginine N-methyltransferase 6.7e-07 32.1 0.1 2.3e-06 30.4 0.0 1.9 1 sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase h 6.8e-07 32.1 0.0 1.8e-06 30.7 0.0 1.6 1 tr|E9PPP6|E9PPP6_HUMAN Ribosomal RNA-processing protein 8 O 7.1e-07 32.0 0.0 1.8e-06 30.7 0.0 1.7 1 tr|E9PKG1|E9PKG1_HUMAN Protein arginine N-methyltransferase 1.1e-06 31.4 0.0 1.6e-06 30.9 0.0 1.3 1 tr|S4R338|S4R338_HUMAN N-terminal Xaa-Pro-Lys N-methyltrans 1.5e-06 31.0 0.0 2.2e-06 30.4 0.0 1.3 1 tr|H3BQD2|H3BQD2_HUMAN Methyltransferase-like protein 9 (Fr 1.7e-06 30.8 0.0 4.9e-06 29.3 0.0 1.8 1 tr|F8VP53|F8VP53_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquin 1.8e-06 30.7 0.0 2.8e-06 30.1 0.0 1.3 1 tr|H3BM54|H3BM54_HUMAN Methyltransferase-like protein 9 (Fr 2.4e-06 30.3 0.0 6e-06 29.0 0.0 1.6 1 sp|Q96LA8|ANM6_HUMAN Protein arginine N-methyltransferase 2.8e-06 30.1 0.1 8e-06 28.6 0.0 1.7 1 sp|Q8TCB7-2|METL6_HUMAN Isoform 2 of Methyltransferase-like 3.3e-06 29.9 0.0 8.4e-06 28.6 0.0 1.7 1 sp|Q9NR22-2|ANM8_HUMAN Isoform 2 of Protein arginine N-meth 3.4e-06 29.8 0.0 8.8e-06 28.5 0.0 1.7 1 sp|Q9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 6e-06 29.0 0.0 6.5e-05 25.7 0.0 2.0 2 tr|H7C552|H7C552_HUMAN Methyltransferase-like protein 2B (F 6.6e-06 28.9 0.0 1.1e-05 28.2 0.0 1.4 1 tr|H3BN86|H3BN86_HUMAN Methyltransferase-like protein 9 (Fr 1e-05 28.3 0.0 1.9e-05 27.4 0.0 1.5 1 sp|Q9H1A3-2|METL9_HUMAN Isoform 2 of Methyltransferase-like 1e-05 28.3 0.0 1.9e-05 27.4 0.0 1.5 1 sp|Q9H1A3|METL9_HUMAN Methyltransferase-like protein 9 OS= 1.5e-05 27.7 0.0 3.2e-05 26.7 0.0 1.6 1 tr|K7EQA8|K7EQA8_HUMAN Histone-arginine methyltransferase C 1.8e-05 27.5 0.0 4e-05 26.4 0.0 1.6 1 sp|Q86X55-2|CARM1_HUMAN Isoform 2 of Histone-arginine methyl 2.1e-05 27.3 0.0 2.8e-05 26.9 0.0 1.3 1 tr|H3BQ23|H3BQ23_HUMAN Anamorsin (Fragment) OS=Homo sapiens 2.9e-05 26.8 0.1 0.00011 25.0 0.0 1.8 1 sp|Q9H825-2|METL8_HUMAN Isoform 2 of Methyltransferase-like 3.2e-05 26.7 0.0 8e-05 25.4 0.0 1.7 1 sp|Q86X55-1|CARM1_HUMAN Isoform 1 of Histone-arginine methyl 3.4e-05 26.6 0.0 8.5e-05 25.3 0.0 1.7 1 sp|Q86X55|CARM1_HUMAN Histone-arginine methyltransferase C 4.1e-05 26.4 0.1 0.00016 24.4 0.0 1.9 1 sp|Q9H825|METL8_HUMAN Methyltransferase-like protein 8 OS= 4.3e-05 26.3 0.1 0.065 16.1 0.0 2.5 2 sp|Q5TEU4-2|NDUF5_HUMAN Isoform 2 of NADH dehydrogenase [ubi 4.7e-05 26.2 0.0 7.8e-05 25.5 0.0 1.4 1 tr|H3BUG4|H3BUG4_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 4.9e-05 26.1 0.0 7.6e-05 25.5 0.0 1.3 1 tr|D6RCL3|D6RCL3_HUMAN Probable dimethyladenosine transfera 6.3e-05 25.8 0.0 9.8e-05 25.1 0.0 1.3 1 sp|Q5VVY1|NTM1B_HUMAN Alpha N-terminal protein methyltrans 6.6e-05 25.7 0.0 0.00014 24.6 0.0 1.5 1 sp|P46597-3|ASMT_HUMAN Isoform 3 of Acetylserotonin O-methy 6.9e-05 25.6 0.0 0.00022 24.0 0.0 1.9 1 sp|Q6FI81|CPIN1_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 7.7e-05 25.5 0.0 0.00013 24.7 0.0 1.5 1 tr|H3BPG7|H3BPG7_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 8.5e-05 25.3 0.0 0.00014 24.6 0.0 1.4 1 tr|H3BV90|H3BV90_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 9.1e-05 25.2 0.0 0.00017 24.4 0.0 1.5 1 tr|H3BT65|H3BT65_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 0.00016 24.5 0.0 0.00032 23.5 0.0 1.5 1 sp|Q9UNQ2|DIM1_HUMAN Probable dimethyladenosine transfera 0.0002 24.2 0.0 0.00034 23.4 0.0 1.4 1 tr|E9PCQ7|E9PCQ7_HUMAN Uncharacterized methyltransferase WB 0.00021 24.1 0.2 0.00053 22.8 0.1 1.7 1 tr|B4DDX3|B4DDX3_HUMAN Methyltransferase-like protein 6 OS= 0.00023 24.0 0.0 0.00034 23.4 0.0 1.2 1 tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS= 0.00023 24.0 0.2 0.00065 22.5 0.2 1.7 1 tr|B7Z972|B7Z972_HUMAN Protein-L-isoaspartate O-methyltrans 0.00024 23.9 0.1 0.00044 23.0 0.1 1.4 1 tr|B7U631|B7U631_HUMAN PRMT2 beta variant OS=Homo sapiens G 0.00028 23.7 0.0 0.00085 22.1 0.0 1.8 1 sp|Q9H7H0-2|MET17_HUMAN Isoform 2 of Methyltransferase-like 0.00028 23.7 0.0 0.00088 22.1 0.0 1.8 1 sp|Q9H7H0|MET17_HUMAN Methyltransferase-like protein 17, m 0.00029 23.6 0.1 0.0005 22.9 0.1 1.4 1 tr|H7C2H9|H7C2H9_HUMAN Protein arginine N-methyltransferase 0.00029 23.6 0.0 0.00095 22.0 0.0 1.8 1 sp|Q9H7H0-3|MET17_HUMAN Isoform 3 of Methyltransferase-like 0.0003 23.6 0.0 0.0045 19.8 0.0 2.2 2 sp|Q7L2J0-2|MEPCE_HUMAN Isoform 2 of 7SK snRNA methylphospha 0.00033 23.4 0.2 0.00097 22.0 0.2 1.8 1 sp|P22061|PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) 0.00033 23.4 0.2 0.00097 21.9 0.2 1.8 1 sp|P22061-2|PIMT_HUMAN Isoform 2 of Protein-L-isoaspartate( 0.0004 23.2 0.1 0.00078 22.3 0.1 1.4 1 tr|F8WD87|F8WD87_HUMAN Uncharacterized methyltransferase WB 0.00042 23.1 0.1 0.00076 22.3 0.1 1.4 1 tr|B7U632|B7U632_HUMAN PRMT2 gamma variant OS=Homo sapiens 0.00042 23.1 0.0 0.00071 22.4 0.0 1.4 1 tr|B7U630|B7U630_HUMAN PRMT2 alpha variant OS=Homo sapiens 0.0005 22.9 0.1 0.0015 21.3 0.1 1.9 1 tr|J3KP72|J3KP72_HUMAN Protein-L-isoaspartate O-methyltrans 0.0005 22.9 0.1 0.0015 21.3 0.1 1.9 1 tr|H7BY58|H7BY58_HUMAN Protein-L-isoaspartate O-methyltrans 0.00054 22.8 0.0 0.001 21.9 0.0 1.4 1 tr|A8MXR3|A8MXR3_HUMAN Protein arginine N-methyltransferase 0.00054 22.8 0.1 0.0012 21.7 0.1 1.5 1 tr|B3KR83|B3KR83_HUMAN Uncharacterized methyltransferase WB 0.00056 22.7 0.0 0.0014 21.5 0.0 1.6 1 sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member 0.00057 22.7 0.1 0.00076 22.3 0.1 1.2 1 tr|H7C1L4|H7C1L4_HUMAN Methyltransferase-like protein 6 (Fr 0.00069 22.4 0.0 0.0013 21.6 0.0 1.4 1 sp|P55345-2|ANM2_HUMAN Isoform 2 of Protein arginine N-meth 0.00069 22.4 0.0 0.0015 21.4 0.0 1.6 1 sp|P55345|ANM2_HUMAN Protein arginine N-methyltransferase 0.00077 22.3 0.0 0.0017 21.2 0.0 1.5 1 sp|P55345-3|ANM2_HUMAN Isoform 3 of Protein arginine N-meth 0.00091 22.0 0.0 0.0049 19.7 0.0 2.3 1 sp|P49327|FAS_HUMAN Fatty acid synthase OS=Homo sapiens 0.0017 21.2 0.3 0.01 18.6 0.2 2.4 1 tr|F2Z2W7|F2Z2W7_HUMAN tRNA (uracil-5-)-methyltransferase h 0.0028 20.5 0.1 0.0073 19.1 0.0 1.6 1 tr|H7C3H9|H7C3H9_HUMAN Methyltransferase-like protein 6 (Fr 0.0047 19.8 0.0 0.011 18.5 0.0 1.6 1 sp|O95671-3|ASML_HUMAN Isoform 3 of N-acetylserotonin O-met 0.0047 19.8 0.0 0.011 18.6 0.0 1.6 1 tr|E7ER97|E7ER97_HUMAN N-acetylserotonin O-methyltransferas 0.0049 19.7 0.0 0.11 15.4 0.0 2.4 1 sp|P40261|NNMT_HUMAN Nicotinamide N-methyltransferase OS= 0.0051 19.6 0.0 0.012 18.5 0.0 1.6 1 sp|Q96RS0|TGS1_HUMAN Trimethylguanosine synthase OS=Homo 0.0052 19.6 0.0 0.013 18.4 0.0 1.6 1 sp|O95671-2|ASML_HUMAN Isoform 2 of N-acetylserotonin O-met 0.0054 19.6 0.0 0.013 18.3 0.0 1.6 1 sp|O95671|ASML_HUMAN N-acetylserotonin O-methyltransferas 0.0069 19.2 0.0 0.018 17.9 0.0 1.7 1 tr|H7C258|H7C258_HUMAN HemK methyltransferase family member ------ inclusion threshold ------ 0.01 18.7 0.0 0.019 17.8 0.0 1.5 1 sp|Q7Z624|CMKMT_HUMAN Calmodulin-lysine N-methyltransferas 0.013 18.3 0.0 0.031 17.1 0.0 1.6 1 tr|H0YIW7|H0YIW7_HUMAN Methyltransferase-like protein 25 (F 0.015 18.1 0.0 0.035 17.0 0.0 1.6 1 tr|F8VZA8|F8VZA8_HUMAN Methyltransferase-like protein 25 (F 0.015 18.1 0.0 0.11 15.4 0.0 2.6 1 sp|Q8N6Q8|MET25_HUMAN Methyltransferase-like protein 25 OS 0.024 17.5 0.0 0.042 16.7 0.0 1.4 1 tr|H7C100|H7C100_HUMAN tRNA (uracil-5-)-methyltransferase h 0.026 17.4 0.1 0.035 17.0 0.1 1.2 1 tr|C9J0F2|C9J0F2_HUMAN Protein-L-isoaspartate(D-aspartate) 0.036 16.9 0.1 0.43 13.5 0.0 2.7 1 sp|Q7Z5W3|BN3D2_HUMAN Pre-miRNA 5'-monophosphate methyltra 0.039 16.8 0.0 0.078 15.8 0.0 1.5 1 sp|A6NDL7|MT21E_HUMAN Putative methyltransferase-like prot 0.067 16.0 0.0 0.19 14.6 0.0 1.8 1 tr|B3KU92|B3KU92_HUMAN Putative protein arginine N-methyltr 0.074 15.9 0.0 0.14 15.0 0.0 1.5 1 tr|H7C4Z8|H7C4Z8_HUMAN Methyltransferase-like protein 2B (F 0.078 15.9 0.0 0.22 14.4 0.0 1.8 1 sp|Q6P2P2|ANM10_HUMAN Putative protein arginine N-methyltr 0.083 15.8 0.0 0.17 14.8 0.0 1.5 1 sp|Q96GJ1-3|TRM2_HUMAN Isoform 3 of tRNA (uracil(54)-C(5))- 0.091 15.6 0.0 0.19 14.6 0.0 1.5 1 sp|Q96GJ1-2|TRM2_HUMAN Isoform 2 of tRNA (uracil(54)-C(5))- 0.092 15.6 0.0 0.19 14.6 0.0 1.5 1 tr|F2Z384|F2Z384_HUMAN tRNA (uracil(54)-C(5))-methyltransfe 0.095 15.6 0.0 0.19 14.6 0.0 1.5 1 sp|Q96GJ1|TRM2_HUMAN tRNA (uracil(54)-C(5))-methyltransfe 0.1 15.5 0.1 0.44 13.4 0.0 1.9 1 tr|E9PMW9|E9PMW9_HUMAN Protein arginine N-methyltransferase 0.11 15.4 0.0 0.17 14.7 0.0 1.4 1 tr|H0Y768|H0Y768_HUMAN tRNA (guanine(10)-N2)-methyltransfer 0.11 15.4 0.0 0.58 13.1 0.0 2.0 1 tr|F5H2D9|F5H2D9_HUMAN mRNA cap guanine-N7 methyltransferas 0.11 15.3 0.1 0.46 13.4 0.0 1.9 1 tr|E9PI83|E9PI83_HUMAN Protein arginine N-methyltransferase 0.12 15.2 0.0 0.39 13.6 0.0 1.8 1 sp|P51580|TPMT_HUMAN Thiopurine S-methyltransferase OS=Ho 0.13 15.1 0.0 1.5 11.7 0.0 2.5 1 sp|O95050-2|INMT_HUMAN Isoform 2 of Indolethylamine N-methy 0.13 15.1 0.0 1.6 11.7 0.0 2.5 1 sp|O95050|INMT_HUMAN Indolethylamine N-methyltransferase 0.15 14.9 0.0 0.31 13.9 0.0 1.5 1 sp|Q9Y5N5|HEMK2_HUMAN HemK methyltransferase family member 0.16 14.9 0.0 0.36 13.7 0.0 1.7 1 tr|A8MT87|A8MT87_HUMAN Phenylethanolamine N-methyltransfera 0.18 14.6 0.0 0.77 12.7 0.0 2.1 1 sp|P11086|PNMT_HUMAN Phenylethanolamine N-methyltransfera 0.2 14.5 0.2 0.27 14.1 0.2 1.5 1 tr|I3L2J5|I3L2J5_HUMAN Methyltransferase-like protein 22 (F 0.25 14.2 0.0 0.5 13.2 0.0 1.6 1 tr|F8WDR2|F8WDR2_HUMAN tRNA (adenine(58)-N(1))-methyltransf 0.26 14.2 0.0 0.74 12.7 0.0 1.8 1 sp|Q8N4J0|CI041_HUMAN UPF0586 protein C9orf41 OS=Homo sapi 0.27 14.1 0.1 1 12.3 0.0 2.1 1 sp|Q6FI81-3|CPIN1_HUMAN Isoform 3 of Anamorsin OS=Homo sapie 0.28 14.1 0.0 0.36 13.7 0.0 1.3 1 tr|H7C2C8|H7C2C8_HUMAN Methyltransferase-like protein 2B (F 0.29 14.0 0.0 0.42 13.5 0.0 1.2 1 tr|H3BQW1|H3BQW1_HUMAN Protein FAM173A (Fragment) OS=Homo s 0.3 14.0 0.0 3.1 10.7 0.0 2.4 2 sp|Q5VZV1|MT21C_HUMAN Protein-lysine methyltransferase MET 0.37 13.7 0.0 0.72 12.8 0.0 1.5 1 tr|F2Z2Q4|F2Z2Q4_HUMAN tRNA (guanine(10)-N2)-methyltransfer 0.4 13.6 0.0 0.75 12.7 0.0 1.5 1 tr|G3V353|G3V353_HUMAN Methyltransferase-like protein 17, m 0.42 13.5 0.0 0.87 12.5 0.0 1.6 1 sp|Q9Y5N5-2|HEMK2_HUMAN Isoform 2 of HemK methyltransferase 0.43 13.5 0.0 34 7.4 0.0 3.3 3 tr|H3BNC0|H3BNC0_HUMAN Protein arginine N-methyltransferase 0.45 13.4 0.0 34 7.4 0.0 3.2 3 sp|Q9NVM4-4|ANM7_HUMAN Isoform 4 of Protein arginine N-meth 0.53 13.2 0.8 1.3 11.9 0.2 1.8 1 tr|M0R0W0|M0R0W0_HUMAN Methyltransferase-like protein 6 (Fr 0.54 13.2 0.1 1 12.3 0.1 1.4 1 tr|F6XBY7|F6XBY7_HUMAN Uncharacterized protein KIAA1456 OS= 0.55 13.1 0.0 1.2 12.1 0.0 1.6 1 sp|Q7Z4G4-2|TRM11_HUMAN Isoform 2 of tRNA (guanine(10)-N2)-m 0.56 13.1 0.0 0.89 12.5 0.0 1.4 1 sp|Q9BV86-2|NTM1A_HUMAN Isoform 2 of N-terminal Xaa-Pro-Lys 0.57 13.1 0.0 2.8 10.8 0.0 2.1 1 sp|Q5T8I9|HENMT_HUMAN Small RNA 2'-O-methyltransferase OS= 0.57 13.1 0.0 1.2 12.1 0.0 1.6 1 sp|Q7Z4G4|TRM11_HUMAN tRNA (guanine(10)-N2)-methyltransfer 0.58 13.0 0.0 1.1 12.2 0.0 1.4 1 tr|J3KMW5|J3KMW5_HUMAN Protein FAM173A OS=Homo sapiens GN=F 0.61 13.0 0.0 1.3 11.9 0.0 1.6 1 sp|Q9H867-5|MT21D_HUMAN Isoform 5 of Protein-lysine methyltr 0.68 12.8 0.0 1.5 11.7 0.0 1.6 1 tr|H3BTF5|H3BTF5_HUMAN Methyltransferase-like protein 22 OS 0.72 12.7 0.0 1.9 11.4 0.0 1.8 1 sp|Q9H867|MT21D_HUMAN Protein-lysine methyltransferase MET 0.77 12.7 0.0 1.3 11.9 0.0 1.3 1 tr|I7HFW6|I7HFW6_HUMAN Acetylserotonin O-methyltransferase 0.8 12.6 0.0 2.6 11.0 0.0 2.0 1 sp|Q9BV44|THUM3_HUMAN THUMP domain-containing protein 3 OS Domain annotation for each sequence (and alignments): >> tr|F8VQX6|F8VQX6_HUMAN Methyltransferase-like protein 7A (Fragment) OS=Homo sapiens GN=METTL7A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 76.3 0.0 2.1e-23 1e-20 1 95 [] 75 172 .. 75 172 .. 0.94 Alignments for each domain: == domain 1 score: 76.3 bits; conditional E-value: 2.1e-23 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCT.SS-TT-EEEEEEES-CCC-CCHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...vefvvadaekl.pfpdnsfDlvvssevlhhvedpekalkei 83 L+vGcGtG++++ + g+rv+++D++p++ k+ + + e+++ +fvva e++ +++d+s+D+vv++ vl+ v+++e++l+e+ tr|F8VQX6|F8VQX6_HUMAN 75 LEVGCGTGANFKFYP-PGCRVTCIDPNPNFEKFLIKSIAENRHlqfERFVVAAGENMhQVADGSVDVVVCTLVLCSVKNQERILREV 160 89*************.889************999888888777688888*******989**************************** PP HHHEEEEEEEEE CS Methyltransf_11 84 aRvLkpgGllvi 95 RvL+pgG +++ tr|F8VQX6|F8VQX6_HUMAN 161 CRVLRPGGAFYF 172 *********986 PP >> sp|Q9NZJ6|COQ3_HUMAN Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial OS=Homo sapiens GN=COQ3 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 75.1 0.1 5.1e-23 2.6e-20 1 95 [] 151 250 .. 151 250 .. 0.97 Alignments for each domain: == domain 1 score: 75.1 bits; conditional E-value: 5.1e-23 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-....EEETTEECCCT.SS-TT-EEEEEEES-CCC-CCHHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl....vefvvadaekl.pfpdnsfDlvvssevlhhvedpekalkeia 84 LdvGcG+G+l+e+l + ga+v+g+D+ +e +k+a+ ++s +++ +e++v+++e++ ++fD+vv+sev++hv d+e +l+ + sp|Q9NZJ6|COQ3_HUMAN 151 LDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQCHKSFDPVldkrIEYRVCSLEEIvEETAETFDAVVASEVVEHVIDLETFLQCCC 239 8**************************************99999*************8688889************************* PP HHEEEEEEEEE CS Methyltransf_11 85 RvLkpgGllvi 95 +vLkpgG l+i sp|Q9NZJ6|COQ3_HUMAN 240 QVLKPGGSLFI 250 ********986 PP >> sp|Q9H8H3|MET7A_HUMAN Methyltransferase-like protein 7A OS=Homo sapiens GN=METTL7A PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 75.3 0.0 4.3e-23 2.2e-20 1 95 [] 75 172 .. 75 172 .. 0.94 Alignments for each domain: == domain 1 score: 75.3 bits; conditional E-value: 4.3e-23 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCT.SS-TT-EEEEEEES-CCC-CCHHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...vefvvadaekl.pfpdnsfDlvvssevlhhvedpekalkeia 84 L+vGcGtG++++ + g+rv+++D++p++ k+ + + e+++ +fvva e++ +++d+s+D+vv++ vl+ v+++e++l+e+ sp|Q9H8H3|MET7A_HUMAN 75 LEVGCGTGANFKFYP-PGCRVTCIDPNPNFEKFLIKSIAENRHlqfERFVVAAGENMhQVADGSVDVVVCTLVLCSVKNQERILREVC 161 89*************.889************999888888777688888*******989***************************** PP HHEEEEEEEEE CS Methyltransf_11 85 RvLkpgGllvi 95 RvL+pgG +++ sp|Q9H8H3|MET7A_HUMAN 162 RVLRPGGAFYF 172 ********986 PP >> tr|H0YI09|H0YI09_HUMAN Methyltransferase-like protein 7A (Fragment) OS=Homo sapiens GN=METTL7A PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 75.3 0.0 4.3e-23 2.2e-20 1 95 [] 75 172 .. 75 172 .. 0.94 Alignments for each domain: == domain 1 score: 75.3 bits; conditional E-value: 4.3e-23 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCT.SS-TT-EEEEEEES-CCC-CCHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...vefvvadaekl.pfpdnsfDlvvssevlhhvedpekalkei 83 L+vGcGtG++++ + g+rv+++D++p++ k+ + + e+++ +fvva e++ +++d+s+D+vv++ vl+ v+++e++l+e+ tr|H0YI09|H0YI09_HUMAN 75 LEVGCGTGANFKFYP-PGCRVTCIDPNPNFEKFLIKSIAENRHlqfERFVVAAGENMhQVADGSVDVVVCTLVLCSVKNQERILREV 160 89*************.889************999888888777688888*******989**************************** PP HHHEEEEEEEEE CS Methyltransf_11 84 aRvLkpgGllvi 95 RvL+pgG +++ tr|H0YI09|H0YI09_HUMAN 161 CRVLRPGGAFYF 172 *********986 PP >> sp|Q6UX53|MET7B_HUMAN Methyltransferase-like protein 7B OS=Homo sapiens GN=METTL7B PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 74.6 0.0 7e-23 3.6e-20 1 95 [] 75 172 .. 75 172 .. 0.93 Alignments for each domain: == domain 1 score: 74.6 bits; conditional E-value: 7e-23 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCT.SS-TT-EEEEEEES-CCC-CCHHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...vefvvadaekl.pfpdnsfDlvvssevlhhvedpekalkeia 84 L++GcGtG++++ + g+rv+++D++p++ k+ + e+++ +fvva e++ +++d+s+D+vv++ vl+ v+ p+k+l+e++ sp|Q6UX53|MET7B_HUMAN 75 LELGCGTGANFQFYP-PGCRVTCLDPNPHFEKFLTKSMAENRHlqyERFVVAPGEDMrQLADGSMDVVVCTLVLCSVQSPRKVLQEVR 161 89************9.889************999777777766688889********99***************************** PP HHEEEEEEEEE CS Methyltransf_11 85 RvLkpgGllvi 95 RvL+pgG+l++ sp|Q6UX53|MET7B_HUMAN 162 RVLRPGGVLFF 172 ********997 PP >> tr|B3KR61|B3KR61_HUMAN HCG1811060, isoform CRA_c OS=Homo sapiens GN=NDUFAF5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 69.2 0.0 3.4e-21 1.7e-18 1 94 [. 94 185 .. 94 186 .. 0.88 Alignments for each domain: == domain 1 score: 69.2 bits; conditional E-value: 3.4e-21 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHH.HHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlkla.kekaseeglvefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaR 85 Ld+GcG+G++a++l k ++++ D+++++lk + ++++++ v ad e lpf++n+fDlvvss +lh+v+d+ +al++i+ tr|B3KR61|B3KR61_HUMAN 94 LDLGCGRGYIAQYLNKETiGKFFQADIAENALKNSsETEIPTV----SVLADEEFLPFKENTFDLVVSSLSLHWVNDLPRALEQIHY 176 8**************7767*************55513333333....38999999******************************** PP HEEEEEEEE CS Methyltransf_11 86 vLkpgGllv 94 +Lkp+G+++ tr|B3KR61|B3KR61_HUMAN 177 ILKPDGVFI 185 ******997 PP >> sp|Q5TEU4|NDUF5_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Homo sapiens GN=NDUFAF # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 68.5 0.0 5.6e-21 2.8e-18 1 94 [. 94 185 .. 94 186 .. 0.88 Alignments for each domain: == domain 1 score: 68.5 bits; conditional E-value: 5.6e-21 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHH.HHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlkla.kekaseeglvefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRv 86 Ld+GcG+G++a++l k ++++ D+++++lk + ++++++ v ad e lpf++n+fDlvvss +lh+v+d+ +al++i+ + sp|Q5TEU4|NDUF5_HUMAN 94 LDLGCGRGYIAQYLNKETiGKFFQADIAENALKNSsETEIPTV----SVLADEEFLPFKENTFDLVVSSLSLHWVNDLPRALEQIHYI 177 8**************7767*************55513333333....38999999********************************* PP EEEEEEEE CS Methyltransf_11 87 LkpgGllv 94 Lkp+G+++ sp|Q5TEU4|NDUF5_HUMAN 178 LKPDGVFI 185 *****997 PP >> sp|Q8N6R0-4|MET13_HUMAN Isoform 2 of Methyltransferase-like protein 13 OS=Homo sapiens GN=METTL13 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 55.5 0.0 6.3e-17 3.2e-14 1 94 [. 53 157 .. 53 158 .. 0.90 2 ? 2.2 0.0 2.7 1.4e+03 28 62 .. 435 465 .. 423 475 .. 0.65 3 ? 3.0 0.0 1.5 7.7e+02 1 39 [. 498 538 .. 498 557 .. 0.81 Alignments for each domain: == domain 1 score: 55.5 bits; conditional E-value: 6.3e-17 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-.EEETTEECCCTSS-TT-EEEEEEES-CCC-.........CC CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl.vefvvadaeklpfpdnsfDlvvssevlhhv.........ed 75 L +GcG+ l+e+l + g +++v++D+s+ ++k+ ke++ ++++ ++f+++d++++ fpd+sf +v+ + +l+ v ++ sp|Q8N6R0-4|MET13_HUMAN 53 LVIGCGNSELSEQLYDVGyRDIVNIDISEVVIKQMKECNATRRPqMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltdeeektlQQ 138 669***********************************999999999****************************98655544448 PP HHHHHHHHHHHEEEEEEEE CS Methyltransf_11 76 pekalkeiaRvLkpgGllv 94 +++ l+e+ RvL+ gG+ + sp|Q8N6R0-4|MET13_HUMAN 139 VDRMLAEVGRVLQVGGRYL 157 8888888888888888765 PP == domain 2 score: 2.2 bits; conditional E-value: 2.7 HHHHHHHHHHCCHHT-EEETTEECCCTS.S-TT-EE CS Methyltransf_11 28 pemlklakekaseeglvefvvadaeklp.fpdnsfD 62 +++ k+++++++ + + adae+lp p +s+D sp|Q8N6R0-4|MET13_HUMAN 435 HKAQ---KKRKKDRK--KQRPADAEDLPaAPGQSID 465 3333...33333332..4499******834456777 PP == domain 3 score: 3.0 bits; conditional E-value: 1.5 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCC CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekas 39 L vG G+G+l +++++ + + +v+++p ml++a + sp|Q8N6R0-4|MET13_HUMAN 498 LVVGLGGGSLPLFVHDHFpkSCIDAVEIDPSMLEVATQWFG 538 5699***********9999888889*********9987655 PP >> tr|B4E2X3|B4E2X3_HUMAN Methyltransferase-like protein 13 OS=Homo sapiens GN=METTL13 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 55.4 0.0 7.2e-17 3.6e-14 1 94 [. 52 156 .. 52 157 .. 0.90 2 ? 2.1 0.0 3 1.5e+03 28 62 .. 434 464 .. 422 474 .. 0.65 3 ? 2.9 0.0 1.7 8.6e+02 1 39 [. 497 537 .. 497 556 .. 0.81 Alignments for each domain: == domain 1 score: 55.4 bits; conditional E-value: 7.2e-17 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-.EEETTEECCCTSS-TT-EEEEEEES-CCC-.........CCH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl.vefvvadaeklpfpdnsfDlvvssevlhhv.........edp 76 L +GcG+ l+e+l + g +++v++D+s+ ++k+ ke++ ++++ ++f+++d++++ fpd+sf +v+ + +l+ v +++ tr|B4E2X3|B4E2X3_HUMAN 52 LVIGCGNSELSEQLYDVGyRDIVNIDISEVVIKQMKECNATRRPqMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltdeeektlQQV 138 669***********************************999999999****************************986555444488 PP HHHHHHHHHHEEEEEEEE CS Methyltransf_11 77 ekalkeiaRvLkpgGllv 94 ++ l+e+ RvL+ gG+ + tr|B4E2X3|B4E2X3_HUMAN 139 DRMLAEVGRVLQVGGRYL 156 888888888888888765 PP == domain 2 score: 2.1 bits; conditional E-value: 3 HHHHHHHHHHCCHHT-EEETTEECCCTS.S-TT-EE CS Methyltransf_11 28 pemlklakekaseeglvefvvadaeklp.fpdnsfD 62 +++ k+++++++ + + adae+lp p +s+D tr|B4E2X3|B4E2X3_HUMAN 434 HKAQ---KKRKKDRK--KQRPADAEDLPaAPGQSID 464 3333...33333332..4499******834456777 PP == domain 3 score: 2.9 bits; conditional E-value: 1.7 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCC CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekas 39 L vG G+G+l +++++ + + +v+++p ml++a + tr|B4E2X3|B4E2X3_HUMAN 497 LVVGLGGGSLPLFVHDHFpkSCIDAVEIDPSMLEVATQWFG 537 5699***********9999888889*********9987655 PP >> sp|Q8N6R0|MET13_HUMAN Methyltransferase-like protein 13 OS=Homo sapiens GN=METTL13 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 55.4 0.0 7.2e-17 3.7e-14 1 94 [. 53 157 .. 53 158 .. 0.90 2 ? 2.1 0.0 3 1.6e+03 28 62 .. 435 465 .. 423 475 .. 0.65 3 ? 2.9 0.0 1.7 8.6e+02 1 39 [. 498 538 .. 498 557 .. 0.81 Alignments for each domain: == domain 1 score: 55.4 bits; conditional E-value: 7.2e-17 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-.EEETTEECCCTSS-TT-EEEEEEES-CCC-.........CCHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl.vefvvadaeklpfpdnsfDlvvssevlhhv.........edpe 77 L +GcG+ l+e+l + g +++v++D+s+ ++k+ ke++ ++++ ++f+++d++++ fpd+sf +v+ + +l+ v ++++ sp|Q8N6R0|MET13_HUMAN 53 LVIGCGNSELSEQLYDVGyRDIVNIDISEVVIKQMKECNATRRPqMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltdeeektlQQVD 140 669***********************************999999999****************************9865554444888 PP HHHHHHHHHEEEEEEEE CS Methyltransf_11 78 kalkeiaRvLkpgGllv 94 + l+e+ RvL+ gG+ + sp|Q8N6R0|MET13_HUMAN 141 RMLAEVGRVLQVGGRYL 157 88888888888888765 PP == domain 2 score: 2.1 bits; conditional E-value: 3 HHHHHHHHHHCCHHT-EEETTEECCCTS.S-TT-EE CS Methyltransf_11 28 pemlklakekaseeglvefvvadaeklp.fpdnsfD 62 +++ k+++++++ + + adae+lp p +s+D sp|Q8N6R0|MET13_HUMAN 435 HKAQ---KKRKKDRK--KQRPADAEDLPaAPGQSID 465 3333...33333332..4499******834456777 PP == domain 3 score: 2.9 bits; conditional E-value: 1.7 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCC CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekas 39 L vG G+G+l +++++ + + +v+++p ml++a + sp|Q8N6R0|MET13_HUMAN 498 LVVGLGGGSLPLFVHDHFpkSCIDAVEIDPSMLEVATQWFG 538 5699***********9999888889*********9987655 PP >> tr|F8VVX6|F8VVX6_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (Fragment) OS=Homo sapiens GN # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 64.3 0.0 1.1e-19 5.8e-17 18 95 .] 82 163 .. 65 163 .. 0.93 Alignments for each domain: == domain 1 score: 64.3 bits; conditional E-value: 1.1e-19 T.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 18 g.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvLkpgGllvi 95 g +rvv +D+++emlk+ k+ka +g + +v +dae+lpf d++fD+ ++ + + +v ++al+e++RvLkpgG++++ tr|F8VVX6|F8VVX6_HUMAN 82 GgSRVVVCDINKEMLKVGKQKALAQGYragLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLC 163 359******************99999999**************************************************975 PP >> sp|Q8N6R0-1|MET13_HUMAN Isoform 4 of Methyltransferase-like protein 13 OS=Homo sapiens GN=METTL13 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 53.3 0.0 3.3e-16 1.7e-13 1 93 [. 53 149 .. 53 151 .. 0.95 2 ? 2.5 0.0 2.2 1.1e+03 28 62 .. 279 309 .. 267 320 .. 0.65 3 ? 3.3 0.0 1.2 6.2e+02 1 39 [. 342 382 .. 342 401 .. 0.81 Alignments for each domain: == domain 1 score: 53.3 bits; conditional E-value: 3.3e-16 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-.EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl.vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalke 82 L +GcG+ l+e+l + g +++v++D+s+ ++k+ ke++ ++++ ++f+++d++++ fpd+sf +v+ + +l+ v ++ ek+l++ sp|Q8N6R0-1|MET13_HUMAN 53 LVIGCGNSELSEQLYDVGyRDIVNIDISEVVIKQMKECNATRRPqMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltDEEEKTLQQ 138 669***********************************999999999******************************999****** PP HHHHEEEEEEE CS Methyltransf_11 83 iaRvLkpgGll 93 + R+L G++ sp|Q8N6R0-1|MET13_HUMAN 139 VDRMLAEVGRV 149 ***99988875 PP == domain 2 score: 2.5 bits; conditional E-value: 2.2 HHHHHHHHHHCCHHT-EEETTEECCCTS.S-TT-EE CS Methyltransf_11 28 pemlklakekaseeglvefvvadaeklp.fpdnsfD 62 +++ k+++++++ + + adae+lp p +s+D sp|Q8N6R0-1|MET13_HUMAN 279 HKAQ---KKRKKDRK--KQRPADAEDLPaAPGQSID 309 3333...33333332..4499******834556777 PP == domain 3 score: 3.3 bits; conditional E-value: 1.2 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCC CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekas 39 L vG G+G+l +++++ + + +v+++p ml++a + sp|Q8N6R0-1|MET13_HUMAN 342 LVVGLGGGSLPLFVHDHFpkSCIDAVEIDPSMLEVATQWFG 382 5699***********9999888889*********9987655 PP >> sp|Q5HYK3|COQ5_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens GN=COQ5 PE=1 SV # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 63.0 0.0 2.9e-19 1.5e-16 18 95 .] 163 244 .. 149 244 .. 0.93 Alignments for each domain: == domain 1 score: 63.0 bits; conditional E-value: 2.9e-19 T.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 18 g.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvLkpgGllvi 95 g +rvv +D+++emlk+ k+ka +g + +v +dae+lpf d++fD+ ++ + + +v ++al+e++RvLkpgG++++ sp|Q5HYK3|COQ5_HUMAN 163 GgSRVVVCDINKEMLKVGKQKALAQGYragLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLC 244 359******************99999999**************************************************975 PP >> sp|Q9P272|K1456_HUMAN Putative methyltransferase KIAA1456 OS=Homo sapiens GN=KIAA1456 PE=2 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 60.4 0.0 1.9e-18 9.7e-16 2 95 .] 50 139 .. 49 139 .. 0.92 Alignments for each domain: == domain 1 score: 60.4 bits; conditional E-value: 1.9e-18 EET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-...CCHHHHHHHHHHH CS Methyltransf_11 2 dvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhv...edpekalkeiaRv 86 d+GcGtG++++ + ++vg+D++ ++++a++++ e+ +v+d +lpf+d+ fD+++s v+hh+ +++ +a+ke+aRv sp|Q9P272|K1456_HUMAN 50 DIGCGTGKYLKVNS-Q-VHTVGCDYCGPLVEIARNRGCEA-----MVCDNLNLPFRDEGFDAIISIGVIHHFstkQRRIRAIKEMARV 130 9**********999.4.47**************9999887.....6777778********************999899********** PP EEEEEEEEE CS Methyltransf_11 87 LkpgGllvi 95 L pgG l+i sp|Q9P272|K1456_HUMAN 131 LVPGGQLMI 139 *****9986 PP >> sp|Q9HBK9|AS3MT_HUMAN Arsenite methyltransferase OS=Homo sapiens GN=AS3MT PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 58.9 0.0 5.8e-18 2.9e-15 1 95 [] 75 183 .. 75 183 .. 0.89 Alignments for each domain: == domain 1 score: 58.9 bits; conditional E-value: 5.8e-18 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT-........EEETTEECCCTS...S-TT-EEEEEEES-CCC-C CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseegl........vefvvadaeklp...fpdnsfDlvvssevlhhve 74 Ld+G+G+Gr + l + + ++v+g+D+++ ++++a++ + v+f+++ +ekl ++++s D+vvs+ v++ v+ sp|Q9HBK9|AS3MT_HUMAN 75 LDLGSGSGRDCYVLSQLVgekGHVTGIDMTKGQVEVAEKYLDYHMEkygfqasnVTFIHGYIEKLGeagIKNESHDIVVSNCVINLVP 162 8**************7778999***************66555554466777788*********9844669****************** PP CHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 75 dpekalkeiaRvLkpgGllvi 95 d +++l+e++RvLk gG l++ sp|Q9HBK9|AS3MT_HUMAN 163 DKQQVLQEAYRVLKHGGELYF 183 *****************9986 PP >> sp|Q96BT7|ALKB8_HUMAN Alkylated DNA repair protein alkB homolog 8 OS=Homo sapiens GN=ALKBH8 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 56.5 0.1 3.2e-17 1.6e-14 2 94 .. 412 500 .. 411 501 .. 0.95 Alignments for each domain: == domain 1 score: 56.5 bits; conditional E-value: 3.2e-17 EET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-...CCHHHHHHHHHHH CS Methyltransf_11 2 dvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhv...edpekalkeiaRv 86 d+GcG+G+++ ++ + +g+D s++++++++e++ ++ v+da +p++++s+D+++s +v+hh+ e++ +al+ei+R+ sp|Q96BT7|ALKB8_HUMAN 412 DIGCGNGKYLGINKELY--MIGCDRSQNLVDICRERQFQA-----FVCDALAVPVRSGSCDACISIAVIHHFataERRVAALQEIVRL 492 9*************888..9***************99998.....6899999********************9999************ PP EEEEEEEE CS Methyltransf_11 87 LkpgGllv 94 L+pgG+ + sp|Q96BT7|ALKB8_HUMAN 493 LRPGGKAL 500 *****976 PP >> sp|Q96BT7-4|ALKB8_HUMAN Isoform 4 of Alkylated DNA repair protein alkB homolog 8 OS=Homo sapiens GN=ALKBH8 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 56.5 0.1 3.2e-17 1.6e-14 2 94 .. 415 503 .. 414 504 .. 0.95 Alignments for each domain: == domain 1 score: 56.5 bits; conditional E-value: 3.2e-17 EET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-...CCHHHHHHHHH CS Methyltransf_11 2 dvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhv...edpekalkeia 84 d+GcG+G+++ ++ + +g+D s++++++++e++ ++ v+da +p++++s+D+++s +v+hh+ e++ +al+ei+ sp|Q96BT7-4|ALKB8_HUMAN 415 DIGCGNGKYLGINKELY--MIGCDRSQNLVDICRERQFQA-----FVCDALAVPVRSGSCDACISIAVIHHFataERRVAALQEIV 493 9*************888..9***************99998.....6899999********************9999********** PP HHEEEEEEEE CS Methyltransf_11 85 RvLkpgGllv 94 R+L+pgG+ + sp|Q96BT7-4|ALKB8_HUMAN 494 RLLRPGGKAL 503 *******976 PP >> sp|O60344-4|ECE2_HUMAN Isoform D of Endothelin-converting enzyme 2 OS=Homo sapiens GN=ECE2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 51.2 0.0 1.5e-15 7.5e-13 1 94 [. 63 172 .. 63 173 .. 0.90 Alignments for each domain: == domain 1 score: 51.2 bits; conditional E-value: 1.5e-15 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-...C......... CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhv...e......... 74 L +GcG+ +l+ +l g +v+ vD+s ++++ +++ + +++ +d++kl+fp++sfD+v+ + +l+ + e sp|O60344-4|ECE2_HUMAN 63 LVLGCGNSALSYELFLGGfPNVTSVDYSSVVVAAMQARHAHVPQLRWETMDVRKLDFPSASFDVVLEKGTLDALlagErdpwtvsse 149 569************7779*************888888888877******************************8652667778888 PP ...CHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 75 ...dpekalkeiaRvLkpgGllv 94 ++++l+e+ RvL pgG+++ sp|O60344-4|ECE2_HUMAN 150 gvhTVDQVLSEVSRVLVPGGRFI 172 888******************97 PP >> sp|Q6P1Q9|MET2B_HUMAN Methyltransferase-like protein 2B OS=Homo sapiens GN=METTL2B PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 46.5 0.0 4.2e-14 2.1e-11 1 94 [. 185 289 .. 185 290 .. 0.85 Alignments for each domain: == domain 1 score: 46.5 bits; conditional E-value: 4.2e-14 EEET-TTSHHHHHHHHTT....SEEEEEES-HHHHHHHHHHCCHHT-.....EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg....arvvgvDlspemlklakekaseegl.....vefvvadaeklpfpdnsfDlvvssevlhhv..edpe 77 L+vGcG G + ++ ++ v+++D+s ++++l++++++ ++ v ++ + ++ p+p++s D++++ +vl v ++++ sp|Q6P1Q9|MET2B_HUMAN 185 LEVGCGVGNTVFPILQTNndpgLFVYCCDFSSTAIELVQTNSEYDPSrcfafVHDLCDEEKSYPVPKGSLDIIILIFVLSAVvpDKMQ 272 89**********9995445566********************999988744322233333457********************99*** PP HHHHHHHHHEEEEEEEE CS Methyltransf_11 78 kalkeiaRvLkpgGllv 94 ka++ + R+LkpgG+++ sp|Q6P1Q9|MET2B_HUMAN 273 KAINRLSRLLKPGGMVL 289 **************986 PP >> sp|Q6P1Q9-2|MET2B_HUMAN Isoform 2 of Methyltransferase-like protein 2B OS=Homo sapiens GN=METTL2B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 47.0 0.0 2.9e-14 1.5e-11 1 94 [. 120 224 .. 120 225 .. 0.85 Alignments for each domain: == domain 1 score: 47.0 bits; conditional E-value: 2.9e-14 EEET-TTSHHHHHHHHTT....SEEEEEES-HHHHHHHHHHCCHHT-.....EEETTEECCCTSS-TT-EEEEEEES-CCC-..CC CS Methyltransf_11 1 LdvGcGtGrlaealakrg....arvvgvDlspemlklakekaseegl.....vefvvadaeklpfpdnsfDlvvssevlhhv..ed 75 L+vGcG G + ++ ++ v+++D+s ++++l++++++ ++ v ++ + ++ p+p++s D++++ +vl v ++ sp|Q6P1Q9-2|MET2B_HUMAN 120 LEVGCGVGNTVFPILQTNndpgLFVYCCDFSSTAIELVQTNSEYDPSrcfafVHDLCDEEKSYPVPKGSLDIIILIFVLSAVvpDK 205 89**********9995445566********************999988744322233333457********************99* PP HHHHHHHHHHHEEEEEEEE CS Methyltransf_11 76 pekalkeiaRvLkpgGllv 94 ++ka++ + R+LkpgG+++ sp|Q6P1Q9-2|MET2B_HUMAN 206 MQKAINRLSRLLKPGGMVL 224 ****************986 PP >> sp|Q96IZ6-2|MET2A_HUMAN Isoform 2 of Methyltransferase-like protein 2A OS=Homo sapiens GN=METTL2A # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 46.6 0.0 3.9e-14 2e-11 1 94 [. 49 153 .. 49 154 .. 0.85 Alignments for each domain: == domain 1 score: 46.6 bits; conditional E-value: 3.9e-14 EEET-TTSHHHHHHHHTT....SEEEEEES-HHHHHHHHHHCCHHT-.....EEETTEECCCTSS-TT-EEEEEEES-CCC-..CC CS Methyltransf_11 1 LdvGcGtGrlaealakrg....arvvgvDlspemlklakekaseegl.....vefvvadaeklpfpdnsfDlvvssevlhhv..ed 75 L+vGcG G + ++ ++ v+++D+s ++++l++++++ ++ v ++ + ++ p+p++s D++++ +vl + ++ sp|Q96IZ6-2|MET2A_HUMAN 49 LEVGCGVGNTVFPILQTNndpgLFVYCCDFSSTAIELVQTNSEYDPSrcfafVHDLCDEEKSYPVPKGSLDIIILIFVLSAIvpDK 134 89**********9995445566********************999988744322233333457********************99* PP HHHHHHHHHHHEEEEEEEE CS Methyltransf_11 76 pekalkeiaRvLkpgGllv 94 ++ka++ + R+LkpgG+++ sp|Q96IZ6-2|MET2A_HUMAN 135 MQKAINRLSRLLKPGGMML 153 ****************976 PP >> sp|Q96IZ6|MET2A_HUMAN Methyltransferase-like protein 2A OS=Homo sapiens GN=METTL2A PE=1 SV=5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 45.3 0.0 1e-13 5.2e-11 1 94 [. 185 289 .. 185 290 .. 0.85 Alignments for each domain: == domain 1 score: 45.3 bits; conditional E-value: 1e-13 EEET-TTSHHHHHHHHTT....SEEEEEES-HHHHHHHHHHCCHHT-.....EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg....arvvgvDlspemlklakekaseegl.....vefvvadaeklpfpdnsfDlvvssevlhhv..edpe 77 L+vGcG G + ++ ++ v+++D+s ++++l++++++ ++ v ++ + ++ p+p++s D++++ +vl + ++++ sp|Q96IZ6|MET2A_HUMAN 185 LEVGCGVGNTVFPILQTNndpgLFVYCCDFSSTAIELVQTNSEYDPSrcfafVHDLCDEEKSYPVPKGSLDIIILIFVLSAIvpDKMQ 272 89**********9995445566********************999988744322233333457********************99*** PP HHHHHHHHHEEEEEEEE CS Methyltransf_11 78 kalkeiaRvLkpgGllv 94 ka++ + R+LkpgG+++ sp|Q96IZ6|MET2A_HUMAN 273 KAINRLSRLLKPGGMML 289 **************976 PP >> tr|B4DP72|B4DP72_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens GN=COQ5 PE=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 45.9 0.0 6.3e-14 3.2e-11 44 95 .] 119 170 .. 104 170 .. 0.92 Alignments for each domain: == domain 1 score: 45.9 bits; conditional E-value: 6.3e-14 EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 44 vefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvLkpgGllvi 95 + +v +dae+lpf d++fD+ ++ + + +v ++al+e++RvLkpgG++++ tr|B4DP72|B4DP72_HUMAN 119 LAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLC 170 6799*********************************************975 PP >> sp|Q9BV86|NTM1A_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens GN=NTMT1 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 43.7 0.0 3.2e-13 1.6e-10 1 95 [] 66 165 .. 66 165 .. 0.92 Alignments for each domain: == domain 1 score: 43.7 bits; conditional E-value: 3.2e-13 EEET-TTSHHHHHHH.HTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT.SS-TT-EEEEEEES-CCC-..CCHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaeala.krgarvvgvDlspemlklakekaseegl..vefvvadaekl.pfpdnsfDlvvssevlhhv..edpekalke 82 Ld+G+G Gr+++ l +++v vD+++ +l +ak+ eeg ++ ++ ++++ p pd s+D++++++v+ h+ + ++++l+ sp|Q9BV86|NTM1A_HUMAN 66 LDCGAGIGRITKRLLlPLFREVDMVDITEDFLVQAKTYLGEEGKrvRNYFCCGLQDFtPEPD-SYDVIWIQWVIGHLtdQHLAEFLRR 152 8**************4555**********************999987899999**9846666.**************9989******* PP HHHHEEEEEEEEE CS Methyltransf_11 83 iaRvLkpgGllvi 95 ++ L+p+G++vi sp|Q9BV86|NTM1A_HUMAN 153 CKGSLRPNGIIVI 165 **********996 PP >> sp|O43709-2|WBS22_HUMAN Isoform 2 of Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 42.7 0.0 6.6e-13 3.4e-10 1 74 [. 58 132 .. 58 160 .. 0.84 Alignments for each domain: == domain 1 score: 42.7 bits; conditional E-value: 6.6e-13 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCC.TSS-TT-EEEEEEES-CCC-...C CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaek.lpfpdnsfDlvvssevlhhv...e 74 Ld+GcGtG+ +l + g+ vg+D+sp+ml+ a ++ e +++ +d+ + +pf+ ++fD ++s ++++++ + sp|O43709-2|WBS22_HUMAN 58 LDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEG---DLLLGDMGQgIPFKPGTFDGCISISAVQWLcnaN 132 8******************************7774444444...359*****978******************96431 PP >> sp|O43709|WBS22_HUMAN Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 42.0 0.0 1e-12 5.3e-10 1 74 [. 58 132 .. 58 161 .. 0.83 Alignments for each domain: == domain 1 score: 42.0 bits; conditional E-value: 1e-12 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCC.TSS-TT-EEEEEEES-CCC-...C CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaek.lpfpdnsfDlvvssevlhhv...e 74 Ld+GcGtG+ +l + g+ vg+D+sp+ml+ a ++ e +++ +d+ + +pf+ ++fD ++s ++++++ + sp|O43709|WBS22_HUMAN 58 LDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEG---DLLLGDMGQgIPFKPGTFDGCISISAVQWLcnaN 132 8******************************7774444444...359*****978******************97431 PP >> tr|C9K060|C9K060_HUMAN Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 41.9 0.0 1.2e-12 5.9e-10 1 74 [. 58 132 .. 58 161 .. 0.83 Alignments for each domain: == domain 1 score: 41.9 bits; conditional E-value: 1.2e-12 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCC.TSS-TT-EEEEEEES-CCC-...C CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaek.lpfpdnsfDlvvssevlhhv...e 74 Ld+GcGtG+ +l + g+ vg+D+sp+ml+ a ++ e +++ +d+ + +pf+ ++fD ++s ++++++ + tr|C9K060|C9K060_HUMAN 58 LDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEG---DLLLGDMGQgIPFKPGTFDGCISISAVQWLcnaN 132 8******************************7774444444...359*****978******************97431 PP >> sp|Q8TCB7|METL6_HUMAN Methyltransferase-like protein 6 OS=Homo sapiens GN=METTL6 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 40.6 0.0 3e-12 1.5e-09 1 92 [. 84 184 .. 84 187 .. 0.88 Alignments for each domain: == domain 1 score: 40.6 bits; conditional E-value: 3e-12 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-.EEETTEECCC...T.SS-TT-EEEEEEES-CCC-..CCHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl.vefvvadaek...l.pfpdnsfDlvvssevlhhv..edpeka 79 L++GcG G + +l + +++D+sp++++++k++ + + +++ ++d++k l +p +s+D+v++ +vl v ++++ + sp|Q8TCB7|METL6_HUMAN 84 LEAGCGVGNCLFPLLEEDpnIFAYACDFSPRAIEYVKQNPLYDTErCKVFQCDLTKddlLdHVPPESVDVVMLIFVLSAVhpDKMHLV 171 799***********95555799**************998877777888899999976766679*****************9889999* PP HHHHHHHEEEEEE CS Methyltransf_11 80 lkeiaRvLkpgGl 92 l++i++vLkpg sp|Q8TCB7|METL6_HUMAN 172 LQNIYKVLKPGKS 184 **********965 PP >> tr|E7ETE0|E7ETE0_HUMAN Methyltransferase-like protein 8 OS=Homo sapiens GN=METTL8 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 39.3 0.0 7.6e-12 3.9e-09 1 95 [] 201 307 .. 201 307 .. 0.88 Alignments for each domain: == domain 1 score: 39.3 bits; conditional E-value: 7.6e-12 EEET-TTSHHHHHHHHTT.....SEEEEEES-HHHHHHHHHHCCHHT-.....EEETTEECCCTSS-TT-EEEEEEES-CCC-..CC CS Methyltransf_11 1 LdvGcGtGrlaealakrg.....arvvgvDlspemlklakekaseegl.....vefvvadaeklpfpdnsfDlvvssevlhhv..ed 75 L+vGcG+G + ++ ++ + ++++D++ +++l+k+++s + v v+ d pfpd+ D++++ +vl + ++ tr|E7ETE0|E7ETE0_HUMAN 201 LEVGCGAGNSVFPILNTLenspeSFLYCCDFASGAVELVKSHSSYRATqcfafVHDVCDDGLPYPFPDGILDVILLVFVLSSIhpDR 287 89**********999555666899*********************99887444333666666689******************9889 PP HHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 76 pekalkeiaRvLkpgGllvi 95 ++ +++ + ++LkpgG+l++ tr|E7ETE0|E7ETE0_HUMAN 288 MQGVVNRLSKLLKPGGMLLF 307 999**************986 PP >> tr|H3BQF6|H3BQF6_HUMAN Uncharacterized protein (Fragment) OS=Homo sapiens PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 38.9 0.0 9.9e-12 5e-09 1 95 [] 49 154 .. 49 154 .. 0.90 Alignments for each domain: == domain 1 score: 38.9 bits; conditional E-value: 9.9e-12 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCTSS-TT-EEEEEEES-CCC-........CCH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl..vefvvadaeklpfpdnsfDlvvssevlhhv........edp 76 Ld+G G+G ++ +lak g ++++g+D+sp +++l+ + +++egl +++ v+d+ +l + + f +++ + +++ + e++ tr|H3BQF6|H3BQF6_HUMAN 49 LDIGTGNGVFLVELAKFGfSNITGIDYSPSAIQLSGSIIEKEGLsnIKLKVEDFLNLSTQLSGFHICIDKGTFDAIslnpdnaiEKR 135 8*****************************************99998889999999888888888888888888887766555569* PP HHHHHHHHHHEEEEEEEEE CS Methyltransf_11 77 ekalkeiaRvLkpgGllvi 95 ++++k + RvLk G+++i tr|H3BQF6|H3BQF6_HUMAN 136 KQYVKSLSRVLKVKGFFLI 154 ***************9975 PP >> sp|Q8N6R0-3|MET13_HUMAN Isoform 3 of Methyltransferase-like protein 13 OS=Homo sapiens GN=METTL13 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 27.4 0.0 3.7e-08 1.9e-05 39 94 .. 7 71 .. 1 72 [. 0.79 2 ? 2.3 0.0 2.6 1.3e+03 28 62 .. 349 379 .. 337 389 .. 0.65 3 ? 3.1 0.0 1.4 7.2e+02 1 39 [. 412 452 .. 412 471 .. 0.81 Alignments for each domain: == domain 1 score: 27.4 bits; conditional E-value: 3.7e-08 CHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-.........CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 39 seeglvefvvadaeklpfpdnsfDlvvssevlhhv.........edpekalkeiaRvLkpgGllv 94 +++ ++f+++d++++ fpd+sf +v+ + +l+ v +++++ l+e+ RvL+ gG+ + sp|Q8N6R0-3|MET13_HUMAN 7 TRRPQMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltdeeektlQQVDRMLAEVGRVLQVGGRYL 71 33333899***************************986555444488888888888888888765 PP == domain 2 score: 2.3 bits; conditional E-value: 2.6 HHHHHHHHHHCCHHT-EEETTEECCCTS.S-TT-EE CS Methyltransf_11 28 pemlklakekaseeglvefvvadaeklp.fpdnsfD 62 +++ k+++++++ + + adae+lp p +s+D sp|Q8N6R0-3|MET13_HUMAN 349 HKAQ---KKRKKDRK--KQRPADAEDLPaAPGQSID 379 3333...33333332..4499******834456777 PP == domain 3 score: 3.1 bits; conditional E-value: 1.4 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCC CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekas 39 L vG G+G+l +++++ + + +v+++p ml++a + sp|Q8N6R0-3|MET13_HUMAN 412 LVVGLGGGSLPLFVHDHFpkSCIDAVEIDPSMLEVATQWFG 452 5699***********9999888889*********9987655 PP >> sp|Q8N6F8|WBS27_HUMAN Williams-Beuren syndrome chromosomal region 27 protein OS=Homo sapiens GN=WBSCR27 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 37.8 0.0 2.1e-11 1.1e-08 1 94 [. 72 164 .. 72 165 .. 0.89 Alignments for each domain: == domain 1 score: 37.8 bits; conditional E-value: 2.1e-11 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHE CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvL 87 Ldv+cGtG++a++l g ++ gvD sp ml++a++ + ++ +++ e lp p+++fD+v++ +l + p a+ e++ v sp|Q8N6F8|WBS27_HUMAN 72 LDVACGTGLVAAELRAPGfLQLHGVDGSPGMLEQAQAPGLYQR-LSLCTLGQEPLPSPEGTFDAVLIVGALSDGQVPCNAIPELH-VT 157 8**************9999**************9998888888.44444455559****************************97.99 PP EEEEEEE CS Methyltransf_11 88 kpgGllv 94 kpgGl++ sp|Q8N6F8|WBS27_HUMAN 158 KPGGLVC 164 ****986 PP >> sp|Q5JPI9|MET10_HUMAN Methyltransferase-like protein 10 OS=Homo sapiens GN=METTL10 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 37.7 0.0 2.4e-11 1.2e-08 1 95 [] 84 189 .. 84 189 .. 0.90 Alignments for each domain: == domain 1 score: 37.7 bits; conditional E-value: 2.4e-11 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCTSS-TT-EEEEEEES-CCC-........CCHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl..vefvvadaeklpfpdnsfDlvvssevlhhv........edpe 77 Ld+G G+G ++ +lak g ++++g+D+sp +++l+ + +++egl +++ v+d+ +l + + f +++ + +++ + e+++ sp|Q5JPI9|MET10_HUMAN 84 LDIGTGNGVFLVELAKFGfSNITGIDYSPSAIQLSGSIIEKEGLsnIKLKVEDFLNLSTQLSGFHICIDKGTFDAIslnpdnaiEKRK 171 8*****************************************99998889999999888888888888888888887766555569** PP HHHHHHHHHEEEEEEEEE CS Methyltransf_11 78 kalkeiaRvLkpgGllvi 95 +++k + RvLk G+++i sp|Q5JPI9|MET10_HUMAN 172 QYVKSLSRVLKVKGFFLI 189 **************9975 PP >> tr|K7EP06|K7EP06_HUMAN mRNA cap guanine-N7 methyltransferase OS=Homo sapiens GN=RNMT PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 34.7 0.0 2.1e-10 1e-07 1 94 [. 24 137 .. 24 138 .. 0.90 Alignments for each domain: == domain 1 score: 34.7 bits; conditional E-value: 2.1e-10 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-.........EEETTEECCC...T.SS-T..T-EEEEEEES-CC CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl.........vefvvadaek...l.pfpd..nsfDlvvssevlh 71 Ld+GcG+G + +++k ++v++D+++ +k++++++++ ++ ef+ ad +k + +f+d fD++ +++v h tr|K7EP06|K7EP06_HUMAN 24 LDLGCGKGGDLLKWKKGRiNKLVCTDIADVSVKQCQQRYEDMKNrrdseyifsAEFITADSSKellIdKFRDpqMCFDICSCQFVCH 110 8*****9999999995557********************9999999999999999999999987754679995459*********** PP C-....CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 72 hv....edpekalkeiaRvLkpgGllv 94 + e+ + l+++ L pgG+++ tr|K7EP06|K7EP06_HUMAN 111 YSfesyEQADMMLRNACERLSPGGYFI 137 *9999889999**************97 PP >> sp|Q7L2J0|MEPCE_HUMAN 7SK snRNA methylphosphate capping enzyme OS=Homo sapiens GN=MEPCE PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 16.5 0.0 9.3e-05 0.047 1 40 [. 448 489 .. 448 503 .. 0.92 2 ! 17.4 0.0 5e-05 0.026 60 95 .] 574 615 .. 551 615 .. 0.87 Alignments for each domain: == domain 1 score: 16.5 bits; conditional E-value: 9.3e-05 EEET-TTSHHHHHHH.HTT.SEEEEEES-HHHHHHHHHHCCH CS Methyltransf_11 1 LdvGcGtGrlaeala.krg.arvvgvDlspemlklakekase 40 Ld+Gc G l+ +a k g +r vg+D++ +++ a+++++ sp|Q7L2J0|MEPCE_HUMAN 448 LDLGCNVGHLTLSIAcKWGpSRMVGLDIDSRLIHSARQNIRH 489 8**************8888*******************9975 PP == domain 2 score: 17.4 bits; conditional E-value: 5e-05 -EEEEEEES-CCC-......CCHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 60 sfDlvvssevlhhv......edpekalkeiaRvLkpgGllvi 95 +D+v++ + +v e +++ ++ i+R L+pgG+lv+ sp|Q7L2J0|MEPCE_HUMAN 574 EYDVVLCLSLTKWVhlnwgdEGLKRMFRRIYRHLRPGGILVL 615 69************77777669*****************985 PP >> sp|Q14749|GNMT_HUMAN Glycine N-methyltransferase OS=Homo sapiens GN=GNMT PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 35.4 0.0 1.3e-10 6.4e-08 1 95 [] 62 175 .. 62 175 .. 0.78 Alignments for each domain: == domain 1 score: 35.4 bits; conditional E-value: 1.3e-10 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...........EEETTEECC......CT.SS-TT-EEEEEEES.-C CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...........vefvvadae......kl.pfpdnsfDlvvsse.vl 70 Ldv+cGtG + l + g +v+ vD s++mlk+a ++ ++++ ++ + +++ fD+v++ ++ sp|Q14749|GNMT_HUMAN 62 LDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHepafdkwvieeA-------NwmtldkDVpQSAEGGFDAVICLGnSF 143 8*******************************99555555555578855443332.......333333235247889******987799 PP CC-.......CCHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 71 hhv.......edpekalkeiaRvLkpgGllvi 95 h+ +++ alk+ia +++ gGllvi sp|Q14749|GNMT_HUMAN 144 AHLpdckgdqSEHRLALKNIASMVRAGGLLVI 175 99976655544******************996 PP >> sp|A8MUP2|MET12_HUMAN Methyltransferase-like protein 12, mitochondrial OS=Homo sapiens GN=METTL12 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 35.5 0.0 1.1e-10 5.6e-08 1 94 [. 80 195 .. 80 196 .. 0.89 Alignments for each domain: == domain 1 score: 35.5 bits; conditional E-value: 1.1e-10 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT-............EEETTEECCCT.SS-T.T-EEEEEEES-CC CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseegl............vefvvadaekl.pfpd.nsfDlvvssevlh 71 LdvGcGt +l+ l + +v+gvD+sp +++ ++ ++ + + f++ada++l +++ +sf l + + +++ sp|A8MUP2|MET12_HUMAN 80 LDVGCGTSSLCTGLYTKSphpVDVLGVDFSPVAVAHMNSLLEGGPGqtplcpghpassLHFMHADAQNLgAVASsGSFQLLLDKGTWD 167 8**************555678*************8887777766556889999999**999********6555548************ PP C-.....CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 72 hv.....edpekalkeiaRvLkpgGllv 94 v ++ ++l+e+ RvL p G+l+ sp|A8MUP2|MET12_HUMAN 168 AVargglPRAYQLLSECLRVLNPQGTLI 195 **888888*****************997 PP >> sp|O43159|RRP8_HUMAN Ribosomal RNA-processing protein 8 OS=Homo sapiens GN=RRP8 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 33.8 0.1 4e-10 2e-07 44 93 .. 340 388 .. 313 390 .. 0.84 Alignments for each domain: == domain 1 score: 33.8 bits; conditional E-value: 4e-10 EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEE CS Methyltransf_11 44 vefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvLkpgGll 93 ++ v+d+ ++p++d+s+D+ v +l+ + +++l+e+ RvLkpgGll sp|O43159|RRP8_HUMAN 340 PRVTVCDMAQVPLEDESVDVAVFCLSLMGT-NIRDFLEEANRVLKPGGLL 388 345899***********************9.6****************97 PP >> tr|H7C2P8|H7C2P8_HUMAN Methyltransferase-like protein 8 (Fragment) OS=Homo sapiens GN=METTL8 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 34.8 0.0 1.9e-10 9.8e-08 1 95 [] 24 143 .. 24 143 .. 0.84 Alignments for each domain: == domain 1 score: 34.8 bits; conditional E-value: 1.9e-10 EEET-TTSHHHHHHHHTT.....SEEEEEES-HHHHHHHHHHCCHHT-............EEE.......TTEECCCTSS-TT-EEE CS Methyltransf_11 1 LdvGcGtGrlaealakrg.....arvvgvDlspemlklakekaseegl............vef.......vvadaeklpfpdnsfDl 63 L+vGcG+G + ++ ++ + ++++D++ +++l+k ++s e v+ d pfpd+ D+ tr|H7C2P8|H7C2P8_HUMAN 24 LEVGCGAGNSVFPILNTLenspeSFLYCCDFASGAVELVKVCYSWESYqlmpkshssyraT-QcfafvhdVCDDGLPYPFPDGILDV 109 89**********999555666899***************9999998877776666555551.04665555777777789******** PP EEEES-CCC-..CCHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 64 vvssevlhhv..edpekalkeiaRvLkpgGllvi 95 +++ +vl + ++++ +++ + ++LkpgG+l++ tr|H7C2P8|H7C2P8_HUMAN 110 ILLVFVLSSIhpDRMQGVVNRLSKLLKPGGMLLF 143 **********9889999**************986 PP >> tr|F8WD67|F8WD67_HUMAN Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 34.7 0.0 2e-10 1e-07 1 64 [. 58 119 .. 58 123 .. 0.86 Alignments for each domain: == domain 1 score: 34.7 bits; conditional E-value: 2e-10 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCC.TSS-TT-EEEE CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaek.lpfpdnsfDlv 64 Ld+GcGtG+ +l + g+ vg+D+sp+ml+ a ++ e +++ +d+ + +pf+ ++fD + tr|F8WD67|F8WD67_HUMAN 58 LDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEG---DLLLGDMGQgIPFKPGTFDGC 119 8******************************7774444444...359*****978********76 PP >> sp|O43148|MCES_HUMAN mRNA cap guanine-N7 methyltransferase OS=Homo sapiens GN=RNMT PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 33.4 0.0 5.2e-10 2.6e-07 1 94 [. 202 315 .. 202 316 .. 0.90 Alignments for each domain: == domain 1 score: 33.4 bits; conditional E-value: 5.2e-10 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-.........EEETTEECCC...T.SS-T..T-EEEEEEES-CCC- CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl.........vefvvadaek...l.pfpd..nsfDlvvssevlhhv 73 Ld+GcG+G + +++k ++v++D+++ +k++++++++ ++ ef+ ad +k + +f+d fD++ +++v h+ sp|O43148|MCES_HUMAN 202 LDLGCGKGGDLLKWKKGRiNKLVCTDIADVSVKQCQQRYEDMKNrrdseyifsAEFITADSSKellIdKFRDpqMCFDICSCQFVCHYS 290 8*****9999999995557********************9999999999999999999999987754679995459************9 PP ....CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 74 ....edpekalkeiaRvLkpgGllv 94 e+ + l+++ L pgG+++ sp|O43148|MCES_HUMAN 291 fesyEQADMMLRNACERLSPGGYFI 315 9998899999*************97 PP >> sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS=Homo sapiens GN=THUMPD2 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 33.6 0.0 4.5e-10 2.3e-07 1 94 [. 303 405 .. 303 406 .. 0.86 Alignments for each domain: == domain 1 score: 33.6 bits; conditional E-value: 4.5e-10 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-....CCHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhv....edpeka 79 Ld cG G ++ + ak +vg D+s+ +l +++ + +gl +e+++ ++ +lp+p++s+D+++s + +d +++ sp|Q9BTF0|THUM2_HUMAN 303 LDPMCGLGTILLEAAKEWpdVYYVGADVSDSQLLGTWDNLKAAGLedkIELLKISVIELPLPSESVDIIISDIPFGKKfklgKDIKSI 390 6788***********888899************555666666666668999********************995544446679***** PP HHHHHHHEEEEEEEE CS Methyltransf_11 80 lkeiaRvLkpgGllv 94 l+e+ RvL gG++v sp|Q9BTF0|THUM2_HUMAN 391 LQEMERVLHVGGTIV 405 ************998 PP >> sp|O43148-2|MCES_HUMAN Isoform 2 of mRNA cap guanine-N7 methyltransferase OS=Homo sapiens GN=RNMT # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 33.2 0.0 5.8e-10 2.9e-07 1 94 [. 202 315 .. 202 316 .. 0.90 Alignments for each domain: == domain 1 score: 33.2 bits; conditional E-value: 5.8e-10 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-.........EEETTEECCC...T.SS-T..T-EEEEEEES-CC CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl.........vefvvadaek...l.pfpd..nsfDlvvssevlh 71 Ld+GcG+G + +++k ++v++D+++ +k++++++++ ++ ef+ ad +k + +f+d fD++ +++v h sp|O43148-2|MCES_HUMAN 202 LDLGCGKGGDLLKWKKGRiNKLVCTDIADVSVKQCQQRYEDMKNrrdseyifsAEFITADSSKellIdKFRDpqMCFDICSCQFVCH 288 8*****9999999995557********************9999999999999999999999987754679995459*********** PP C-....CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 72 hv....edpekalkeiaRvLkpgGllv 94 + e+ + l+++ L pgG+++ sp|O43148-2|MCES_HUMAN 289 YSfesyEQADMMLRNACERLSPGGYFI 315 *99998899999*************97 PP >> tr|F8VVW7|F8VVW7_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (Fragment) OS=Homo sapiens GN # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 33.8 0.0 3.8e-10 2e-07 18 72 .. 113 171 .. 99 176 .] 0.88 Alignments for each domain: == domain 1 score: 33.8 bits; conditional E-value: 3.8e-10 T.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC CS Methyltransf_11 18 g.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhh 72 g +rvv +D+++emlk+ k+ka +g + +v +dae+lpf d++fD+ ++ + + + tr|F8VVW7|F8VVW7_HUMAN 113 GgSRVVVCDINKEMLKVGKQKALAQGYragLAWVLGDAEELPFDDDKFDIYTIAFGIRN 171 359******************99999999*********************999876655 PP >> sp|O60344|ECE2_HUMAN Endothelin-converting enzyme 2 OS=Homo sapiens GN=ECE2 PE=1 SV=4 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 33.1 0.0 6.5e-10 3.3e-07 1 73 [. 63 136 .. 63 158 .. 0.87 Alignments for each domain: == domain 1 score: 33.1 bits; conditional E-value: 6.5e-10 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC- CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhv 73 L +GcG+ +l+ +l g +v+ vD+s ++++ +++ + +++ +d++kl+fp++sfD+v+ + +l+ + sp|O60344|ECE2_HUMAN 63 LVLGCGNSALSYELFLGGfPNVTSVDYSSVVVAAMQARHAHVPQLRWETMDVRKLDFPSASFDVVLEKGTLDAL 136 569************7779*************888888888877**********************99988877 PP >> sp|O60678-2|ANM3_HUMAN Isoform 2 of Protein arginine N-methyltransferase 3 OS=Homo sapiens GN=PRMT3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 32.9 0.0 7.6e-10 3.9e-07 1 91 [. 198 294 .. 198 297 .. 0.78 Alignments for each domain: == domain 1 score: 32.9 bits; conditional E-value: 7.6e-10 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHH...HHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-...CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlkla...kekaseeglvefvvadaeklpfpdnsfDlvvssevlhhv...edpekal 80 LdvGcGtG+l+ ak g ++v+gvD s+ + ++ + ++ e+ ++++++ +e++ +p +++D+++s ++ ++ ++++l sp|O60678-2|ANM3_HUMAN 198 LDVGCGTGILSMFAAKAGaKKVLGVDQSEILYQAMdiiRLNKLEDT-ITLIKGKIEEVHLPVEKVDVIISEWMGYFLlfeSMLDSVL 283 8*************************99988844432244444444.999********************99666555556666666 PP HHHHHHEEEEE CS Methyltransf_11 81 keiaRvLkpgG 91 + L +gG sp|O60678-2|ANM3_HUMAN 284 YAKNKYLAKGG 294 66666666666 PP >> sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 3 OS=Homo sapiens GN=PRMT3 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 32.6 0.0 9.3e-10 4.7e-07 1 91 [. 260 356 .. 260 359 .. 0.78 Alignments for each domain: == domain 1 score: 32.6 bits; conditional E-value: 9.3e-10 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHH...HHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-...CCHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlkla...kekaseeglvefvvadaeklpfpdnsfDlvvssevlhhv...edpekalke 82 LdvGcGtG+l+ ak g ++v+gvD s+ + ++ + ++ e+ ++++++ +e++ +p +++D+++s ++ ++ ++++l sp|O60678|ANM3_HUMAN 260 LDVGCGTGILSMFAAKAGaKKVLGVDQSEILYQAMdiiRLNKLEDT-ITLIKGKIEEVHLPVEKVDVIISEWMGYFLlfeSMLDSVLYA 347 8*************************99988844432244444444.999********************9966655555666666666 PP HHHHEEEEE CS Methyltransf_11 83 iaRvLkpgG 91 + L +gG sp|O60678|ANM3_HUMAN 348 KNKYLAKGG 356 666666666 PP >> tr|E9PNR9|E9PNR9_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 33.1 0.0 6.5e-10 3.3e-07 1 93 [. 47 145 .. 47 146 .. 0.82 Alignments for each domain: == domain 1 score: 33.1 bits; conditional E-value: 6.5e-10 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l tr|E9PNR9|E9PNR9_HUMAN 47 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVL 132 8******************99***9822245566666666665554.9***********************9555566668999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++L p+Gl+ tr|E9PNR9|E9PNR9_HUMAN 133 YARDKWLAPDGLI 145 9999999999987 PP >> tr|H3BLW2|H3BLW2_HUMAN Methyltransferase-like protein 13 (Fragment) OS=Homo sapiens GN=METTL13 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 29.4 0.0 9e-09 4.6e-06 35 94 .. 5 74 .. 1 75 [. 0.78 Alignments for each domain: == domain 1 score: 29.4 bits; conditional E-value: 9e-09 HHHCCHHT-.EEETTEECCCTSS-TT-EEEEEEES-CCC-.........CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 35 kekaseegl.vefvvadaeklpfpdnsfDlvvssevlhhv.........edpekalkeiaRvLkpgGllv 94 ke++ ++++ ++f+++d++++ fpd+sf +v+ + +l+ v +++++ l+e+ RvL+ gG+ + tr|H3BLW2|H3BLW2_HUMAN 5 KECNATRRPqMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltdeeektlQQVDRMLAEVGRVLQVGGRYL 74 4444444445899***************************986555444488888888888888888765 PP >> tr|H0YDE4|H0YDE4_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 31.6 0.0 1.8e-09 9.2e-07 1 93 [. 103 201 .. 103 202 .. 0.82 Alignments for each domain: == domain 1 score: 31.6 bits; conditional E-value: 1.8e-09 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l tr|H0YDE4|H0YDE4_HUMAN 103 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVL 188 8******************99***9822245566666666665554.9***********************9555566668999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++L p+Gl+ tr|H0YDE4|H0YDE4_HUMAN 189 YARDKWLAPDGLI 201 9999999999987 PP >> tr|E9PQ98|E9PQ98_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 32.1 0.0 1.3e-09 6.4e-07 1 93 [. 47 145 .. 47 146 .. 0.82 Alignments for each domain: == domain 1 score: 32.1 bits; conditional E-value: 1.3e-09 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l tr|E9PQ98|E9PQ98_HUMAN 47 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVL 132 8******************99***9822245566666666665554.9***********************9555566668999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++L p+Gl+ tr|E9PQ98|E9PQ98_HUMAN 133 YARDKWLAPDGLI 145 9999999999987 PP >> tr|E9PIX6|E9PIX6_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 32.1 0.0 1.3e-09 6.7e-07 1 93 [. 47 145 .. 47 146 .. 0.82 Alignments for each domain: == domain 1 score: 32.1 bits; conditional E-value: 1.3e-09 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l tr|E9PIX6|E9PIX6_HUMAN 47 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVL 132 8******************99***9822245566666666665554.9***********************9555566668999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++L p+Gl+ tr|E9PIX6|E9PIX6_HUMAN 133 YARDKWLAPDGLI 145 9999999999987 PP >> sp|Q8N6R0-2|MET13_HUMAN Isoform 5 of Methyltransferase-like protein 13 OS=Homo sapiens GN=METTL13 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 28.3 0.0 2e-08 9.9e-06 39 94 .. 7 71 .. 1 72 [. 0.79 Alignments for each domain: == domain 1 score: 28.3 bits; conditional E-value: 2e-08 CHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-.........CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 39 seeglvefvvadaeklpfpdnsfDlvvssevlhhv.........edpekalkeiaRvLkpgGllv 94 +++ ++f+++d++++ fpd+sf +v+ + +l+ v +++++ l+e+ RvL+ gG+ + sp|Q8N6R0-2|MET13_HUMAN 7 TRRPQMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltdeeektlQQVDRMLAEVGRVLQVGGRYL 71 33333899***************************986555444488888888888888888765 PP >> sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.6 0.0 4e-09 2e-06 1 55 [. 437 494 .. 437 499 .. 0.96 Alignments for each domain: == domain 1 score: 30.6 bits; conditional E-value: 4e-09 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT.S CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl..vefvvadaekl.p 55 Ldv cGtG + ala++++rv+gv+l+pe+++ a+ +a++++l vef++++ae+l p sp|Q8IZ69-2|TRM2A_HUMAN 437 LDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELsnVEFHCGRAEDLvP 494 89***************************************99***********9855 PP >> sp|Q99873-2|ANM1_HUMAN Isoform 2 of Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.5 0.0 4e-09 2e-06 1 93 [. 69 167 .. 69 168 .. 0.82 Alignments for each domain: == domain 1 score: 30.5 bits; conditional E-value: 4e-09 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l sp|Q99873-2|ANM1_HUMAN 69 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVL 154 8******************99***9822245566666666665554.9**********************99555566668999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++L p+Gl+ sp|Q99873-2|ANM1_HUMAN 155 YARDKWLAPDGLI 167 9999999999987 PP >> sp|Q99873-3|ANM1_HUMAN Isoform 3 of Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.6 0.0 3.9e-09 2e-06 1 93 [. 65 163 .. 65 164 .. 0.82 Alignments for each domain: == domain 1 score: 30.6 bits; conditional E-value: 3.9e-09 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l sp|Q99873-3|ANM1_HUMAN 65 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVL 150 8******************99***9822245566666666665554.9**********************99555566668999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++L p+Gl+ sp|Q99873-3|ANM1_HUMAN 151 YARDKWLAPDGLI 163 9999999999987 PP >> sp|Q99873-4|ANM1_HUMAN Isoform 4 of Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.5 0.0 4.1e-09 2.1e-06 1 93 [. 75 173 .. 75 174 .. 0.82 Alignments for each domain: == domain 1 score: 30.5 bits; conditional E-value: 4.1e-09 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l sp|Q99873-4|ANM1_HUMAN 75 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVL 160 8******************99***9822245566666666665554.9**********************99555566668999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++L p+Gl+ sp|Q99873-4|ANM1_HUMAN 161 YARDKWLAPDGLI 173 9999999999987 PP >> sp|Q99873|ANM1_HUMAN Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.4 0.0 4.3e-09 2.2e-06 1 93 [. 83 181 .. 83 182 .. 0.82 Alignments for each domain: == domain 1 score: 30.4 bits; conditional E-value: 4.3e-09 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekalke 82 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l sp|Q99873|ANM1_HUMAN 83 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVLYA 170 8******************99***9822245566666666665554.9**********************9955556666899999999 PP HHHHEEEEEEE CS Methyltransf_11 83 iaRvLkpgGll 93 ++L p+Gl+ sp|Q99873|ANM1_HUMAN 171 RDKWLAPDGLI 181 99999999987 PP >> tr|H7C2I1|H7C2I1_HUMAN Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.4 0.0 4.5e-09 2.3e-06 1 93 [. 93 191 .. 93 192 .. 0.82 Alignments for each domain: == domain 1 score: 30.4 bits; conditional E-value: 4.5e-09 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l tr|H7C2I1|H7C2I1_HUMAN 93 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVL 178 8******************99***9822245566666666665554.9**********************99555566668999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++L p+Gl+ tr|H7C2I1|H7C2I1_HUMAN 179 YARDKWLAPDGLI 191 9999999999987 PP >> sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.4 0.0 4.6e-09 2.3e-06 1 55 [. 437 494 .. 437 499 .. 0.96 Alignments for each domain: == domain 1 score: 30.4 bits; conditional E-value: 4.6e-09 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT.S CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl..vefvvadaekl.p 55 Ldv cGtG + ala++++rv+gv+l+pe+++ a+ +a++++l vef++++ae+l p sp|Q8IZ69|TRM2A_HUMAN 437 LDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELsnVEFHCGRAEDLvP 494 89***************************************99***********9855 PP >> tr|E9PPP6|E9PPP6_HUMAN Ribosomal RNA-processing protein 8 OS=Homo sapiens GN=RRP8 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.7 0.0 3.5e-09 1.8e-06 52 93 .. 32 72 .. 18 74 .. 0.90 Alignments for each domain: == domain 1 score: 30.7 bits; conditional E-value: 3.5e-09 CCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEE CS Methyltransf_11 52 eklpfpdnsfDlvvssevlhhvedpekalkeiaRvLkpgGll 93 k+p++d+s+D+ v +l+ + +++l+e+ RvLkpgGll tr|E9PPP6|E9PPP6_HUMAN 32 NKVPLEDESVDVAVFCLSLMGT-NIRDFLEEANRVLKPGGLL 72 579******************9.6****************97 PP >> tr|E9PKG1|E9PKG1_HUMAN Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.7 0.0 3.5e-09 1.8e-06 1 93 [. 47 145 .. 47 146 .. 0.82 Alignments for each domain: == domain 1 score: 30.7 bits; conditional E-value: 3.5e-09 EEET-TTSHHHHHHHHTT.SEEEEEE...S-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvD...lspemlklakekaseeglvefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ +s++++k++k+++ + v+++++ +e++ +p +++D+++s + +l++ ++ +l tr|E9PKG1|E9PKG1_HUMAN 47 LDVGSGTGILCMFAAKAGaRKVIGIEcssISDYAVKIVKANKLDHV-VTIIKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVL 132 8******************99***9822245566666666665554.9**********************99555566668999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++L p+Gl+ tr|E9PKG1|E9PKG1_HUMAN 133 YARDKWLAPDGLI 145 9999999999987 PP >> tr|S4R338|S4R338_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens GN=NTMT1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.9 0.0 3.1e-09 1.6e-06 24 95 .] 2 77 .. 1 77 [. 0.91 Alignments for each domain: == domain 1 score: 30.9 bits; conditional E-value: 3.1e-09 EES-HHHHHHHHHHCCHHT-..EEETTEECCCT.SS-TT-EEEEEEES-CCC-..CCHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 24 vDlspemlklakekaseegl..vefvvadaekl.pfpdnsfDlvvssevlhhv..edpekalkeiaRvLkpgGllvi 95 vD+++ +l +ak+ eeg ++ ++ ++++ p pd s+D++++++v+ h+ + ++++l+ ++ L+p+G++vi tr|S4R338|S4R338_HUMAN 2 VDITEDFLVQAKTYLGEEGKrvRNYFCCGLQDFtPEPD-SYDVIWIQWVIGHLtdQHLAEFLRRCKGSLRPNGIIVI 77 899999**999999999999987889999999846666.**************9989*****************996 PP >> tr|H3BQD2|H3BQD2_HUMAN Methyltransferase-like protein 9 (Fragment) OS=Homo sapiens GN=METTL9 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.4 0.0 4.3e-09 2.2e-06 1 89 [. 21 102 .. 21 109 .. 0.86 Alignments for each domain: == domain 1 score: 30.4 bits; conditional E-value: 4.3e-09 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHE CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvL 87 Ld+G+G G +++ + +++++++++ls++m+ ++ +++++ +v + + + ++D++ + + l+ +++p +lk i+ vL tr|H3BQD2|H3BQD2_HUMAN 21 LDLGAGDGEVTKIMSPHFEEIYATELSETMI---WQLQKKKY----RVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVL 100 8******************************...44444443....666777666666689************************** PP EE CS Methyltransf_11 88 kp 89 +p tr|H3BQD2|H3BQD2_HUMAN 101 EP 102 99 PP >> tr|F8VP53|F8VP53_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (Fragment) OS=Homo sapiens GN # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 29.3 0.0 9.6e-09 4.9e-06 18 62 .. 82 130 .] 66 130 .] 0.90 Alignments for each domain: == domain 1 score: 29.3 bits; conditional E-value: 9.6e-09 T.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EE CS Methyltransf_11 18 g.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfD 62 g +rvv +D+++emlk+ k+ka +g + +v +dae+lpf d++fD tr|F8VP53|F8VP53_HUMAN 82 GgSRVVVCDINKEMLKVGKQKALAQGYragLAWVLGDAEELPFDDDKFD 130 359******************99999999*******************9 PP >> tr|H3BM54|H3BM54_HUMAN Methyltransferase-like protein 9 (Fragment) OS=Homo sapiens GN=METTL9 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 30.1 0.0 5.5e-09 2.8e-06 1 89 [. 39 120 .. 39 127 .. 0.86 Alignments for each domain: == domain 1 score: 30.1 bits; conditional E-value: 5.5e-09 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHE CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvL 87 Ld+G+G G +++ + +++++++++ls++m+ ++ +++++ +v + + + ++D++ + + l+ +++p +lk i+ vL tr|H3BM54|H3BM54_HUMAN 39 LDLGAGDGEVTKIMSPHFEEIYATELSETMI---WQLQKKKY----RVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVL 118 8******************************...44444443....666777666666689************************** PP EE CS Methyltransf_11 88 kp 89 +p tr|H3BM54|H3BM54_HUMAN 119 EP 120 99 PP >> sp|Q96LA8|ANM6_HUMAN Protein arginine N-methyltransferase 6 OS=Homo sapiens GN=PRMT6 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 29.0 0.0 1.2e-08 6e-06 1 93 [. 87 184 .. 87 185 .. 0.87 Alignments for each domain: == domain 1 score: 29.0 bits; conditional E-value: 1.2e-08 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvsse...vlhhvedpekalke 82 LdvG+GtG+l+ +a+ g +rv++v+ s+ ++a+e ++ +gl v ++ + +e++ +p+ ++D++vs + l h ++++l sp|Q96LA8|ANM6_HUMAN 87 LDVGAGTGILSIFCAQAGaRRVYAVEASAIW-QQAREVVRFNGLedrVHVLPGPVETVELPE-QVDAIVSEWmgyGLLHESMLSSVLHA 173 8*************************87766.478787777777888999***********9.*********5554555578******* PP HHHHEEEEEEE CS Methyltransf_11 83 iaRvLkpgGll 93 ++Lk gGll sp|Q96LA8|ANM6_HUMAN 174 RTKWLKEGGLL 184 *********98 PP >> sp|Q8TCB7-2|METL6_HUMAN Isoform 2 of Methyltransferase-like protein 6 OS=Homo sapiens GN=METTL6 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 28.6 0.0 1.6e-08 8e-06 1 85 [. 84 177 .. 84 179 .. 0.86 Alignments for each domain: == domain 1 score: 28.6 bits; conditional E-value: 1.6e-08 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-.EEETTEECCC...T.SS-TT-EEEEEEES-CCC-..CCHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl.vefvvadaek...l.pfpdnsfDlvvssevlhhv..edpe 77 L++GcG G + +l + +++D+sp++++++k++ + + +++ ++d++k l +p +s+D+v++ +vl v ++++ sp|Q8TCB7-2|METL6_HUMAN 84 LEAGCGVGNCLFPLLEEDpnIFAYACDFSPRAIEYVKQNPLYDTErCKVFQCDLTKddlLdHVPPESVDVVMLIFVLSAVhpDKMH 169 799***********95555799**************998877777888899999976766679*****************877778 PP HHHHHHHH CS Methyltransf_11 78 kalkeiaR 85 +l++i++ sp|Q8TCB7-2|METL6_HUMAN 170 LVLQNIYK 177 88888876 PP >> sp|Q9NR22-2|ANM8_HUMAN Isoform 2 of Protein arginine N-methyltransferase 8 OS=Homo sapiens GN=PRMT8 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 28.6 0.0 1.7e-08 8.4e-06 1 93 [. 107 205 .. 107 206 .. 0.85 Alignments for each domain: == domain 1 score: 28.6 bits; conditional E-value: 1.7e-08 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvsse...vlhhvedpekal 80 LdvG+GtG+l+ ak g ++v+g++ s ++++ ++ ++l +++ ++ +e++ +p +++D+++s + +l++ ++ ++ sp|Q9NR22-2|ANM8_HUMAN 107 LDVGSGTGILSMFAAKAGaKKVFGIECSSISD-YSEKIIKANHLdniITIFKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVI 192 8*************************776655.55555555555667999*********************9555666669999999 PP HHHHHHEEEEEEE CS Methyltransf_11 81 keiaRvLkpgGll 93 ++LkpgGl+ sp|Q9NR22-2|ANM8_HUMAN 193 FARDKWLKPGGLM 205 999********87 PP >> sp|Q9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 8 OS=Homo sapiens GN=PRMT8 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 28.5 0.0 1.7e-08 8.8e-06 1 93 [. 116 214 .. 116 215 .. 0.85 Alignments for each domain: == domain 1 score: 28.5 bits; conditional E-value: 1.7e-08 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES...-CCC-CCHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvsse...vlhhvedpekalke 82 LdvG+GtG+l+ ak g ++v+g++ s ++++ ++ ++l +++ ++ +e++ +p +++D+++s + +l++ ++ ++ sp|Q9NR22|ANM8_HUMAN 116 LDVGSGTGILSMFAAKAGaKKVFGIECSSISD-YSEKIIKANHLdniITIFKGKVEEVELPVEKVDIIISEWmgyCLFYESMLNTVIFA 203 8*************************776655.55555555555667999*********************955566666999999999 PP HHHHEEEEEEE CS Methyltransf_11 83 iaRvLkpgGll 93 ++LkpgGl+ sp|Q9NR22|ANM8_HUMAN 204 RDKWLKPGGLM 214 9********87 PP >> tr|H7C552|H7C552_HUMAN Methyltransferase-like protein 2B (Fragment) OS=Homo sapiens GN=METTL2B PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.7 0.0 1.3e-07 6.5e-05 53 94 .. 10 53 .. 3 54 .. 0.90 2 ? 1.3 0.0 5.1 2.6e+03 46 76 .. 78 109 .. 59 124 .. 0.74 Alignments for each domain: == domain 1 score: 25.7 bits; conditional E-value: 1.3e-07 CTSS-TT-EEEEEEES-CCC-..CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 53 klpfpdnsfDlvvssevlhhv..edpekalkeiaRvLkpgGllv 94 + p+p++s D++++ +vl v ++++ka++ + R+LkpgG+++ tr|H7C552|H7C552_HUMAN 10 SYPVPKGSLDIIILIFVLSAVvpDKMQKAINRLSRLLKPGGMVL 53 469*******************99*****************986 PP == domain 2 score: 1.3 bits; conditional E-value: 5.1 ETTEECCCT.SS-TT-EEEEEEES-CCC-CCH CS Methyltransf_11 46 fvvadaekl.pfpdnsfDlvvssevlhhvedp 76 +v++d +++ f + D + ++ l+ v+++ tr|H7C552|H7C552_HUMAN 78 YVRGDGTRVyFFTQEELDTLFTTAGLEKVQNL 109 68999999867999999999999999998543 PP >> tr|H3BN86|H3BN86_HUMAN Methyltransferase-like protein 9 (Fragment) OS=Homo sapiens GN=METTL9 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 28.2 0.0 2.2e-08 1.1e-05 1 89 [. 110 191 .. 110 198 .. 0.86 Alignments for each domain: == domain 1 score: 28.2 bits; conditional E-value: 2.2e-08 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHE CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvL 87 Ld+G+G G +++ + +++++++++ls++m+ ++ +++++ +v + + + ++D++ + + l+ +++p +lk i+ vL tr|H3BN86|H3BN86_HUMAN 110 LDLGAGDGEVTKIMSPHFEEIYATELSETMI---WQLQKKKY----RVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVL 189 8******************************...44444443....666777666666689************************** PP EE CS Methyltransf_11 88 kp 89 +p tr|H3BN86|H3BN86_HUMAN 190 EP 191 99 PP >> sp|Q9H1A3-2|METL9_HUMAN Isoform 2 of Methyltransferase-like protein 9 OS=Homo sapiens GN=METTL9 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 27.4 0.0 3.7e-08 1.9e-05 1 89 [. 150 231 .. 150 238 .. 0.86 Alignments for each domain: == domain 1 score: 27.4 bits; conditional E-value: 3.7e-08 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRv 86 Ld+G+G G +++ + +++++++++ls++m+ ++ +++++ +v + + + ++D++ + + l+ +++p +lk i+ v sp|Q9H1A3-2|METL9_HUMAN 150 LDLGAGDGEVTKIMSPHFEEIYATELSETMI---WQLQKKKY----RVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSV 228 8******************************...44444443....666777666666689************************* PP EEE CS Methyltransf_11 87 Lkp 89 L+p sp|Q9H1A3-2|METL9_HUMAN 229 LEP 231 *99 PP >> sp|Q9H1A3|METL9_HUMAN Methyltransferase-like protein 9 OS=Homo sapiens GN=METTL9 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 27.4 0.0 3.8e-08 1.9e-05 1 89 [. 150 231 .. 150 238 .. 0.86 Alignments for each domain: == domain 1 score: 27.4 bits; conditional E-value: 3.8e-08 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEE CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvLk 88 Ld+G+G G +++ + +++++++++ls++m+ ++ +++++ +v + + + ++D++ + + l+ +++p +lk i+ vL+ sp|Q9H1A3|METL9_HUMAN 150 LDLGAGDGEVTKIMSPHFEEIYATELSETMI---WQLQKKKY----RVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLE 230 8******************************...44444443....666777666666689**************************9 PP E CS Methyltransf_11 89 p 89 p sp|Q9H1A3|METL9_HUMAN 231 P 231 9 PP >> tr|K7EQA8|K7EQA8_HUMAN Histone-arginine methyltransferase CARM1 (Fragment) OS=Homo sapiens GN=CARM1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 26.7 0.0 6.4e-08 3.2e-05 1 92 [. 148 243 .. 148 245 .. 0.84 Alignments for each domain: == domain 1 score: 26.7 bits; conditional E-value: 6.4e-08 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalk 81 LdvGcG+G+l+ a+ g +++++v+ + +m + a+ ++ ++l + ++ + +e++ +p+ ++D+++s + + e++ + tr|K7EQA8|K7EQA8_HUMAN 148 LDVGCGSGILSFFAAQAGaRKIYAVE-ASTMAQHAEVLVKSNNLtdrIVVIPGKVEEVSLPE-QVDIIISEPMGYMLfnERMLESYL 232 8*************************.56777888777777766778778***********9.*******98777777667777777 PP HHHHHEEEEEE CS Methyltransf_11 82 eiaRvLkpgGl 92 +++ Lkp G tr|K7EQA8|K7EQA8_HUMAN 233 HAKKYLKPSGN 243 88888888885 PP >> sp|Q86X55-2|CARM1_HUMAN Isoform 2 of Histone-arginine methyltransferase CARM1 OS=Homo sapiens GN=CARM1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 26.4 0.0 7.8e-08 4e-05 1 92 [. 189 284 .. 189 286 .. 0.84 Alignments for each domain: == domain 1 score: 26.4 bits; conditional E-value: 7.8e-08 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhv..edpekal 80 LdvGcG+G+l+ a+ g +++++v+ + +m + a+ ++ ++l + ++ + +e++ +p+ ++D+++s + + e++ + sp|Q86X55-2|CARM1_HUMAN 189 LDVGCGSGILSFFAAQAGaRKIYAVE-ASTMAQHAEVLVKSNNLtdrIVVIPGKVEEVSLPE-QVDIIISEPMGYMLfnERMLESY 272 8*************************.56777888777777766778778***********9.*******9877777766777777 PP HHHHHHEEEEEE CS Methyltransf_11 81 keiaRvLkpgGl 92 +++ Lkp G sp|Q86X55-2|CARM1_HUMAN 273 LHAKKYLKPSGN 284 788888888885 PP >> tr|H3BQ23|H3BQ23_HUMAN Anamorsin (Fragment) OS=Homo sapiens GN=CIAPIN1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 26.9 0.0 5.6e-08 2.8e-05 4 94 .. 5 94 .. 2 95 .. 0.72 Alignments for each domain: == domain 1 score: 26.9 bits; conditional E-value: 5.6e-08 T-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCCT.S..S-TT-EEEEEEES-CCC-.CCHHHHHHHHHHHEE CS Methyltransf_11 4 GcGtGrlaealakrgarvvgvDlspemlklakekaseeglvefvvadaekl.p..fpdnsfDlvvssevlhhv.edpekalkeiaRvLk 88 G +G++++ + + v+ + +++ ++ + +eg ++ v+++++l + +++sfD+++s v +++l+eiaR+L+ tr|H3BQ23|H3BQ23_HUMAN 5 GISAGQFVAVVW---DKSSPVEALKGLVDKLQALTGNEG--RVSVENIKQLlQsaHKESSFDIILSGLVPGSTtLHSAEILAEIARILR 88 555555555555...333455666666777777777777..457888887544448889*********9888876799*********** PP EEEEEE CS Methyltransf_11 89 pgGllv 94 pgG l+ tr|H3BQ23|H3BQ23_HUMAN 89 PGGCLF 94 ***997 PP >> sp|Q9H825-2|METL8_HUMAN Isoform 2 of Methyltransferase-like protein 8 OS=Homo sapiens GN=METTL8 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.0 0.0 2.2e-07 0.00011 1 76 [. 151 235 .. 151 240 .. 0.83 Alignments for each domain: == domain 1 score: 25.0 bits; conditional E-value: 2.2e-07 EEET-TTSHHHHHHHHTT.....SEEEEEES-HHHHHHHHHHCCHHT-.....EEETTEECCCTSS-TT-EEEEEEES-CCC-CCH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.....arvvgvDlspemlklakekaseegl.....vefvvadaeklpfpdnsfDlvvssevlhhvedp 76 L+vGcG+G + ++ ++ + ++++D++ +++l+k+++s + v v+ d pfpd+ D++++ +vl ++ p sp|Q9H825-2|METL8_HUMAN 151 LEVGCGAGNSVFPILNTLenspeSFLYCCDFASGAVELVKSHSSYRATqcfafVHDVCDDGLPYPFPDGILDVILLVFVLSSIH-P 235 89**********999555666899*********************99887444333666666689***************9995.3 PP >> sp|Q86X55-1|CARM1_HUMAN Isoform 1 of Histone-arginine methyltransferase CARM1 OS=Homo sapiens GN=CARM1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.4 0.0 1.6e-07 8e-05 1 92 [. 189 284 .. 189 286 .. 0.83 Alignments for each domain: == domain 1 score: 25.4 bits; conditional E-value: 1.6e-07 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhv..edpekal 80 LdvGcG+G+l+ a+ g +++++v+ + +m + a+ ++ ++l + ++ + +e++ +p+ ++D+++s + + e++ + sp|Q86X55-1|CARM1_HUMAN 189 LDVGCGSGILSFFAAQAGaRKIYAVE-ASTMAQHAEVLVKSNNLtdrIVVIPGKVEEVSLPE-QVDIIISEPMGYMLfnERMLESY 272 8*************************.56777888777777766778778***********9.*******9877777766777777 PP HHHHHHEEEEEE CS Methyltransf_11 81 keiaRvLkpgGl 92 +++ Lkp G sp|Q86X55-1|CARM1_HUMAN 273 LHAKKYLKPSGN 284 788888888885 PP >> sp|Q86X55|CARM1_HUMAN Histone-arginine methyltransferase CARM1 OS=Homo sapiens GN=CARM1 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.3 0.0 1.7e-07 8.5e-05 1 92 [. 189 284 .. 189 286 .. 0.83 Alignments for each domain: == domain 1 score: 25.3 bits; conditional E-value: 1.7e-07 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalke 82 LdvGcG+G+l+ a+ g +++++v+ + +m + a+ ++ ++l + ++ + +e++ +p+ ++D+++s + + e++ + sp|Q86X55|CARM1_HUMAN 189 LDVGCGSGILSFFAAQAGaRKIYAVE-ASTMAQHAEVLVKSNNLtdrIVVIPGKVEEVSLPE-QVDIIISEPMGYMLfnERMLESYLH 274 8*************************.56777888777777766778778***********9.*******987777776677777778 PP HHHHEEEEEE CS Methyltransf_11 83 iaRvLkpgGl 92 +++ Lkp G sp|Q86X55|CARM1_HUMAN 275 AKKYLKPSGN 284 8888888885 PP >> sp|Q9H825|METL8_HUMAN Methyltransferase-like protein 8 OS=Homo sapiens GN=METTL8 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.4 0.0 3.2e-07 0.00016 1 76 [. 201 285 .. 201 290 .. 0.83 Alignments for each domain: == domain 1 score: 24.4 bits; conditional E-value: 3.2e-07 EEET-TTSHHHHHHHHTT.....SEEEEEES-HHHHHHHHHHCCHHT-.....EEETTEECCCTSS-TT-EEEEEEES-CCC-CCH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.....arvvgvDlspemlklakekaseegl.....vefvvadaeklpfpdnsfDlvvssevlhhvedp 76 L+vGcG+G + ++ ++ + ++++D++ +++l+k+++s + v v+ d pfpd+ D++++ +vl ++ p sp|Q9H825|METL8_HUMAN 201 LEVGCGAGNSVFPILNTLenspeSFLYCCDFASGAVELVKSHSSYRATqcfafVHDVCDDGLPYPFPDGILDVILLVFVLSSIH-P 285 89**********999555666899*********************99887444333666666689***************9985.3 PP >> sp|Q5TEU4-2|NDUF5_HUMAN Isoform 2 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Homo sa # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 7.9 0.1 0.046 23 1 16 [. 94 109 .. 94 129 .. 0.87 2 ! 16.1 0.0 0.00013 0.065 68 94 .. 131 157 .. 120 158 .. 0.91 Alignments for each domain: == domain 1 score: 7.9 bits; conditional E-value: 0.046 EEET-TTSHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealak 16 Ld+GcG+G++a++l k sp|Q5TEU4-2|NDUF5_HUMAN 94 LDLGCGRGYIAQYLNK 109 8************985 PP == domain 2 score: 16.1 bits; conditional E-value: 0.00013 S-CCC-CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 68 evlhhvedpekalkeiaRvLkpgGllv 94 +lh+v+d+ +al++i+ +Lkp+G+++ sp|Q5TEU4-2|NDUF5_HUMAN 131 LCLHWVNDLPRALEQIHYILKPDGVFI 157 489*********************997 PP >> tr|H3BUG4|H3BUG4_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.5 0.0 1.5e-07 7.8e-05 23 94 .. 21 94 .. 2 95 .. 0.71 Alignments for each domain: == domain 1 score: 25.5 bits; conditional E-value: 1.5e-07 EEES-HHHHHHHHHHCCHHT-EEETTEECCCT.S..S-TT-EEEEEEES-CCC-.CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 23 gvDlspemlklakekaseeglvefvvadaekl.p..fpdnsfDlvvssevlhhv.edpekalkeiaRvLkpgGllv 94 v+ + +++ ++ + +eg ++ v+++++l + +++sfD+++s v +++l+eiaR+L+pgG l+ tr|H3BUG4|H3BUG4_HUMAN 21 PVEALKGLVDKLQALTGNEG--RVSVENIKQLlQsaHKESSFDIILSGLVPGSTtLHSAEILAEIARILRPGGCLF 94 55555666666677777777..457888887544448889*********9888876799**************997 PP >> tr|D6RCL3|D6RCL3_HUMAN Probable dimethyladenosine transferase OS=Homo sapiens GN=DIMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.5 0.0 1.5e-07 7.6e-05 1 64 [. 61 125 .. 61 133 .. 0.88 Alignments for each domain: == domain 1 score: 25.5 bits; conditional E-value: 1.5e-07 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEE CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlv 64 L+vG GtG ++ +l +++++vv+++l+p++++ ++++++ ++ ++++v+d+ k+++p fD + tr|D6RCL3|D6RCL3_HUMAN 61 LEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKRVQGTPVaskLQVLVGDVLKTDLPF--FDTC 125 89*************************************9999***999*****9855543..5554 PP >> sp|Q5VVY1|NTM1B_HUMAN Alpha N-terminal protein methyltransferase 1B OS=Homo sapiens GN=METTL11B PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.1 0.0 1.9e-07 9.8e-05 1 95 [] 121 220 .. 121 220 .. 0.87 Alignments for each domain: == domain 1 score: 25.1 bits; conditional E-value: 1.9e-07 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl..vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalkei 83 Ld+G+G Gr+++++ + +v vD+ + +l a++ + +g ++++ +++++ p +D++++++v h+ +d+ ++l+ + sp|Q5VVY1|NTM1B_HUMAN 121 LDCGSGIGRVSKHVLLPVfNSVELVDMMESFLLEAQNYLQVKGDkvESYHCYSLQEFTPPFRRYDVIWIQWVSGHLtdKDLLAFLSRC 208 8**************6667*************8887766666666667899999997445556*************999********* PP HHHEEEEEEEEE CS Methyltransf_11 84 aRvLkpgGllvi 95 + Lk +G++++ sp|Q5VVY1|NTM1B_HUMAN 209 RDGLKENGIIIL 220 *********985 PP >> sp|P46597-3|ASMT_HUMAN Isoform 3 of Acetylserotonin O-methyltransferase OS=Homo sapiens GN=ASMT # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.6 0.0 2.8e-07 0.00014 6 94 .. 217 308 .. 215 309 .. 0.88 Alignments for each domain: == domain 1 score: 24.6 bits; conditional E-value: 2.8e-07 TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHHHHHHH CS Methyltransf_11 6 GtGrlaealakrg..arvvgvDlspemlklakekaseegl..vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalkeiaRv 86 G+G+la++++ + ++++ +D+ pe++ +ak++ s +++ ++f+++d+ k p+p+ Dl ++ vlh + + +++l+ i+ sp|P46597-3|ASMT_HUMAN 217 GAGALAKECMSLYpgCKITVFDI-PEVVWTAKQHFSFQEEeqIDFQEGDFFKDPLPE--ADLYILARVLHDWadGKCSHLLERIYHT 300 8999******88889*******7.666668888877777779***************..9************765799********* PP EEEEEEEE CS Methyltransf_11 87 LkpgGllv 94 +kpgG ++ sp|P46597-3|ASMT_HUMAN 301 CKPGGGIL 308 ****9765 PP >> sp|Q6FI81|CPIN1_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.0 0.0 4.4e-07 0.00022 23 94 .. 21 94 .. 2 95 .. 0.71 Alignments for each domain: == domain 1 score: 24.0 bits; conditional E-value: 4.4e-07 EEES-HHHHHHHHHHCCHHT-EEETTEECCCT.S..S-TT-EEEEEEES-CCC-.CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 23 gvDlspemlklakekaseeglvefvvadaekl.p..fpdnsfDlvvssevlhhv.edpekalkeiaRvLkpgGllv 94 v+ + +++ ++ + +eg ++ v+++++l + +++sfD+++s v +++l+eiaR+L+pgG l+ sp|Q6FI81|CPIN1_HUMAN 21 PVEALKGLVDKLQALTGNEG--RVSVENIKQLlQsaHKESSFDIILSGLVPGSTtLHSAEILAEIARILRPGGCLF 94 45555566666666677776..457788887544347889*********9888876799**************997 PP >> tr|H3BPG7|H3BPG7_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.7 0.0 2.6e-07 0.00013 23 94 .. 21 94 .. 2 95 .. 0.71 Alignments for each domain: == domain 1 score: 24.7 bits; conditional E-value: 2.6e-07 EEES-HHHHHHHHHHCCHHT-EEETTEECCCT.S..S-TT-EEEEEEES-CCC-.CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 23 gvDlspemlklakekaseeglvefvvadaekl.p..fpdnsfDlvvssevlhhv.edpekalkeiaRvLkpgGllv 94 v+ + +++ ++ + +eg ++ v+++++l + +++sfD+++s v +++l+eiaR+L+pgG l+ tr|H3BPG7|H3BPG7_HUMAN 21 PVEALKGLVDKLQALTGNEG--RVSVENIKQLlQsaHKESSFDIILSGLVPGSTtLHSAEILAEIARILRPGGCLF 94 55555666666667777776..457788887544448889*********9888876799**************997 PP >> tr|H3BV90|H3BV90_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.6 0.0 2.8e-07 0.00014 23 94 .. 21 94 .. 2 95 .. 0.71 Alignments for each domain: == domain 1 score: 24.6 bits; conditional E-value: 2.8e-07 EEES-HHHHHHHHHHCCHHT-EEETTEECCCT.S..S-TT-EEEEEEES-CCC-.CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 23 gvDlspemlklakekaseeglvefvvadaekl.p..fpdnsfDlvvssevlhhv.edpekalkeiaRvLkpgGllv 94 v+ + +++ ++ + +eg ++ v+++++l + +++sfD+++s v +++l+eiaR+L+pgG l+ tr|H3BV90|H3BV90_HUMAN 21 PVEALKGLVDKLQALTGNEG--RVSVENIKQLlQsaHKESSFDIILSGLVPGSTtLHSAEILAEIARILRPGGCLF 94 55555666666667777776..457788887544448889*********9888876799**************997 PP >> tr|H3BT65|H3BT65_HUMAN Anamorsin OS=Homo sapiens GN=CIAPIN1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.4 0.0 3.3e-07 0.00017 23 94 .. 21 94 .. 2 95 .. 0.71 Alignments for each domain: == domain 1 score: 24.4 bits; conditional E-value: 3.3e-07 EEES-HHHHHHHHHHCCHHT-EEETTEECCCT.S..S-TT-EEEEEEES-CCC-.CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 23 gvDlspemlklakekaseeglvefvvadaekl.p..fpdnsfDlvvssevlhhv.edpekalkeiaRvLkpgGllv 94 v+ + +++ ++ + +eg ++ v+++++l + +++sfD+++s v +++l+eiaR+L+pgG l+ tr|H3BT65|H3BT65_HUMAN 21 PVEALKGLVDKLQALTGNEG--RVSVENIKQLlQsaHKESSFDIILSGLVPGSTtLHSAEILAEIARILRPGGCLF 94 45555666666666777776..457788887544448889*********9888876799**************997 PP >> sp|Q9UNQ2|DIM1_HUMAN Probable dimethyladenosine transferase OS=Homo sapiens GN=DIMT1 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 23.5 0.0 6.4e-07 0.00032 1 64 [. 61 125 .. 61 132 .. 0.88 Alignments for each domain: == domain 1 score: 23.5 bits; conditional E-value: 6.4e-07 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEE CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlv 64 L+vG GtG ++ +l +++++vv+++l+p++++ ++++++ ++ ++++v+d+ k+++p fD + sp|Q9UNQ2|DIM1_HUMAN 61 LEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKRVQGTPVaskLQVLVGDVLKTDLPF--FDTC 125 89*************************************9999***999*****9855443..4444 PP >> tr|E9PCQ7|E9PCQ7_HUMAN Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 23.4 0.0 6.7e-07 0.00034 1 33 [. 58 90 .. 58 111 .. 0.93 Alignments for each domain: == domain 1 score: 23.4 bits; conditional E-value: 6.7e-07 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlkl 33 Ld+GcGtG+ +l + g+ vg+D+sp+ml++ tr|E9PCQ7|E9PCQ7_HUMAN 58 LDIGCGTGLSGSYLSDEGHYWVGLDISPAMLAF 90 8*****************************975 PP >> tr|B4DDX3|B4DDX3_HUMAN Methyltransferase-like protein 6 OS=Homo sapiens GN=METTL6 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.8 0.1 1e-06 0.00053 40 93 .. 79 140 .. 63 142 .. 0.76 Alignments for each domain: == domain 1 score: 22.8 bits; conditional E-value: 1e-06 HHT-..EEETTEECCC...T.SS-TT-EEEEEEES-CCC-..CCHHHHHHHHHHHEEEEEEE CS Methyltransf_11 40 eegl..vefvvadaek...l.pfpdnsfDlvvssevlhhv..edpekalkeiaRvLkpgGll 93 + +++ ++d++k l +p +s+D+v++ +vl v ++++ +l++i++vLkpg + tr|B4DDX3|B4DDX3_HUMAN 79 LYDTerCKVFQCDLTKddlLdHVPPESVDVVMLIFVLSAVhpDKMHLVLQNIYKVLKPGKSV 140 3333666667888886565567999***************9889999***********9655 PP >> tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 23.4 0.0 6.8e-07 0.00034 2 67 .. 57 126 .. 56 133 .. 0.93 Alignments for each domain: == domain 1 score: 23.4 bits; conditional E-value: 6.8e-07 EET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT.SS-TT-EEEEEEE CS Methyltransf_11 2 dvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl..vefvvadaekl.pfpdnsfDlvvss 67 d+GcG G l+ a g + +vg+D+++ +l++ +++a+e +l +++v++d+ l + ++sfD v+++ tr|E7EMN2|E7EMN2_HUMAN 57 DLGCGCGVLSIGTAMLGaGLCVGFDIDEDALEIFNRNAEEFELtnIDMVQCDVCLLsNRMSKSFDTVIMN 126 99************9999********************999999**********99667789*****986 PP >> tr|B7Z972|B7Z972_HUMAN Protein-L-isoaspartate O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.5 0.2 1.3e-06 0.00065 1 93 [. 48 144 .. 48 146 .. 0.80 Alignments for each domain: == domain 1 score: 22.5 bits; conditional E-value: 1.3e-06 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT-.......EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseegl.......vefvvadaeklpfpdnsfDlvvssevlhhvedpe 77 LdvG+G+G+l++ +a+ + ++v+g+D +e+++ + ++++++++ v++vv+d + +++ +D++ + ++ v+ tr|B7Z972|B7Z972_HUMAN 48 LDVGSGSGILTACFARMVgctGKVIGIDHIKELVDDSVNNVRKDDPtllssgrVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVP--- 131 8**************88889**************9888888888878999***999*****96455567999998887776663... PP HHHHHHHHHEEEEEEE CS Methyltransf_11 78 kalkeiaRvLkpgGll 93 + + LkpgG+l tr|B7Z972|B7Z972_HUMAN 132 ---QALIDQLKPGGRL 144 ...3333345666666 PP >> tr|B7U631|B7U631_HUMAN PRMT2 beta variant OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 23.0 0.1 8.7e-07 0.00044 1 73 [. 142 221 .. 142 229 .. 0.79 Alignments for each domain: == domain 1 score: 23.0 bits; conditional E-value: 8.7e-07 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES....-CCC- CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvsse....vlhhv 73 LdvGcGtG+++ +a+++ + v++v+ s+ + + + + ++g+ +++ ++ +e++ +p+ ++D+ vs + lhh tr|B7U631|B7U631_HUMAN 142 LDVGCGTGIISLFCAHYArpRAVYAVEASEMAQHTG-QLVLQNGFadiITVYQQKVEDVVLPE-KVDVLVSEWmgtcLLHHT 221 8**************88899*******777666444.44444455588999*******99999.9******99555555555 PP >> sp|Q9H7H0-2|MET17_HUMAN Isoform 2 of Methyltransferase-like protein 17, mitochondrial OS=Homo sapiens GN=METTL17 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.1 0.0 1.7e-06 0.00085 2 85 .. 191 286 .. 190 292 .. 0.84 Alignments for each domain: == domain 1 score: 22.1 bits; conditional E-value: 1.7e-06 EET-TTSHHHHHHH....HTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCC..TSS-TT.-EEEEEEES-CCC-...CC CS Methyltransf_11 2 dvGcGtGrlaeala....krgarvvgvDlspemlklakekaseegl..vefvvadaek..lpfpdn.sfDlvvssevlhhv...ed 75 d+G+GtG+++ a + + +++++vD s++ml la++ ++ + ++ + + + lp+ + +fD+vvs ++l + +d sp|Q9H7H0-2|MET17_HUMAN 191 DFGSGTGSVTWAAHsiwgQSLREYMCVDRSAAMLVLAEKLLKGGSEsgEPYIPGVFFRqfLPVSPKvQFDVVVSAFSLSELpskAD 276 99********99996554444*************999998888888897789999987678976655**************88778 PP HHHHHHHHHH CS Methyltransf_11 76 pekalkeiaR 85 + ++++ ++R sp|Q9H7H0-2|MET17_HUMAN 277 RTEVVQTLWR 286 8888888877 PP >> sp|Q9H7H0|MET17_HUMAN Methyltransferase-like protein 17, mitochondrial OS=Homo sapiens GN=METTL17 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.1 0.0 1.7e-06 0.00088 2 85 .. 191 286 .. 190 292 .. 0.84 Alignments for each domain: == domain 1 score: 22.1 bits; conditional E-value: 1.7e-06 EET-TTSHHHHHHH....HTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCC..TSS-TT.-EEEEEEES-CCC-...CCHH CS Methyltransf_11 2 dvGcGtGrlaeala....krgarvvgvDlspemlklakekaseegl..vefvvadaek..lpfpdn.sfDlvvssevlhhv...edpe 77 d+G+GtG+++ a + + +++++vD s++ml la++ ++ + ++ + + + lp+ + +fD+vvs ++l + +d+ sp|Q9H7H0|MET17_HUMAN 191 DFGSGTGSVTWAAHsiwgQSLREYMCVDRSAAMLVLAEKLLKGGSEsgEPYIPGVFFRqfLPVSPKvQFDVVVSAFSLSELpskADRT 278 99********99996554444*************999998888888897789999987678976655**************8877888 PP HHHHHHHH CS Methyltransf_11 78 kalkeiaR 85 ++++ ++R sp|Q9H7H0|MET17_HUMAN 279 EVVQTLWR 286 88888877 PP >> tr|H7C2H9|H7C2H9_HUMAN Protein arginine N-methyltransferase 2 (Fragment) OS=Homo sapiens GN=PRMT2 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.9 0.1 9.8e-07 0.0005 1 69 [. 82 153 .. 82 165 .. 0.81 Alignments for each domain: == domain 1 score: 22.9 bits; conditional E-value: 9.8e-07 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES- CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssev 69 LdvGcGtG+++ +a+++ + v++v+ s+ + + + + ++g+ +++ ++ +e++ +p+ ++D+ vs ++ tr|H7C2H9|H7C2H9_HUMAN 82 LDVGCGTGIISLFCAHYArpRAVYAVEASEMAQHTG-QLVLQNGFadiITVYQQKVEDVVLPE-KVDVLVSEWM 153 8**************88899*******777666444.44444455588999*******99999.9***999875 PP >> sp|Q9H7H0-3|MET17_HUMAN Isoform 3 of Methyltransferase-like protein 17, mitochondrial OS=Homo sapiens GN=METTL17 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.0 0.0 1.9e-06 0.00095 2 85 .. 191 286 .. 190 292 .. 0.84 Alignments for each domain: == domain 1 score: 22.0 bits; conditional E-value: 1.9e-06 EET-TTSHHHHHHH....HTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCC..TSS-TT.-EEEEEEES-CCC-...CC CS Methyltransf_11 2 dvGcGtGrlaeala....krgarvvgvDlspemlklakekaseegl..vefvvadaek..lpfpdn.sfDlvvssevlhhv...ed 75 d+G+GtG+++ a + + +++++vD s++ml la++ ++ + ++ + + + lp+ + +fD+vvs ++l + +d sp|Q9H7H0-3|MET17_HUMAN 191 DFGSGTGSVTWAAHsiwgQSLREYMCVDRSAAMLVLAEKLLKGGSEsgEPYIPGVFFRqfLPVSPKvQFDVVVSAFSLSELpskAD 276 99********99996554444*************999998888888897789999987678976655**************88778 PP HHHHHHHHHH CS Methyltransf_11 76 pekalkeiaR 85 + ++++ ++R sp|Q9H7H0-3|MET17_HUMAN 277 RTEVVQTLWR 286 8888888877 PP >> sp|Q7L2J0-2|MEPCE_HUMAN Isoform 2 of 7SK snRNA methylphosphate capping enzyme OS=Homo sapiens GN=MEPCE # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 1.5 0.0 4.5 2.3e+03 22 40 .. 2 20 .. 1 34 [. 0.88 2 ! 19.8 0.0 8.9e-06 0.0045 60 95 .] 105 146 .. 79 146 .. 0.86 Alignments for each domain: == domain 1 score: 1.5 bits; conditional E-value: 4.5 EEEES-HHHHHHHHHHCCH CS Methyltransf_11 22 vgvDlspemlklakekase 40 vg+D++ +++ a+++++ sp|Q7L2J0-2|MEPCE_HUMAN 2 VGLDIDSRLIHSARQNIRH 20 89************99975 PP == domain 2 score: 19.8 bits; conditional E-value: 8.9e-06 -EEEEEEES-CCC-......CCHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 60 sfDlvvssevlhhv......edpekalkeiaRvLkpgGllvi 95 +D+v++ + +v e +++ ++ i+R L+pgG+lv+ sp|Q7L2J0-2|MEPCE_HUMAN 105 EYDVVLCLSLTKWVhlnwgdEGLKRMFRRIYRHLRPGGILVL 146 69************77777669*****************985 PP >> sp|P22061|PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=1 SV=4 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.0 0.2 1.9e-06 0.00097 1 93 [. 83 179 .. 83 181 .. 0.80 Alignments for each domain: == domain 1 score: 22.0 bits; conditional E-value: 1.9e-06 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT-.......EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseegl.......vefvvadaeklpfpdnsfDlvvssevlhhvedpeka 79 LdvG+G+G+l++ +a+ + ++v+g+D +e+++ + ++++++++ v++vv+d + +++ +D++ + ++ v+ sp|P22061|PIMT_HUMAN 83 LDVGSGSGILTACFARMVgctGKVIGIDHIKELVDDSVNNVRKDDPtllssgrVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVP----- 166 8**************88889**************9888888888878999***999*****96455567999998887776663..... PP HHHHHHHEEEEEEE CS Methyltransf_11 80 lkeiaRvLkpgGll 93 + + LkpgG+l sp|P22061|PIMT_HUMAN 167 -QALIDQLKPGGRL 179 .3333345666665 PP >> sp|P22061-2|PIMT_HUMAN Isoform 2 of Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.9 0.2 1.9e-06 0.00097 1 93 [. 83 179 .. 83 181 .. 0.80 Alignments for each domain: == domain 1 score: 21.9 bits; conditional E-value: 1.9e-06 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT-.......EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseegl.......vefvvadaeklpfpdnsfDlvvssevlhhvedpe 77 LdvG+G+G+l++ +a+ + ++v+g+D +e+++ + ++++++++ v++vv+d + +++ +D++ + ++ v+ sp|P22061-2|PIMT_HUMAN 83 LDVGSGSGILTACFARMVgctGKVIGIDHIKELVDDSVNNVRKDDPtllssgrVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVP--- 166 8**************88889**************9888888888878999***999*****96455567999998887776663... PP HHHHHHHHHEEEEEEE CS Methyltransf_11 78 kalkeiaRvLkpgGll 93 + + LkpgG+l sp|P22061-2|PIMT_HUMAN 167 ---QALIDQLKPGGRL 179 ...3333345666665 PP >> tr|F8WD87|F8WD87_HUMAN Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.3 0.1 1.5e-06 0.00078 1 31 [. 58 88 .. 58 92 .. 0.97 Alignments for each domain: == domain 1 score: 22.3 bits; conditional E-value: 1.5e-06 EEET-TTSHHHHHHHHTTSEEEEEES-HHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspeml 31 Ld+GcGtG+ +l + g+ vg+D+sp+ml tr|F8WD87|F8WD87_HUMAN 58 LDIGCGTGLSGSYLSDEGHYWVGLDISPAML 88 8****************************98 PP >> tr|B7U632|B7U632_HUMAN PRMT2 gamma variant OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.3 0.1 1.5e-06 0.00076 1 69 [. 142 213 .. 142 224 .. 0.81 Alignments for each domain: == domain 1 score: 22.3 bits; conditional E-value: 1.5e-06 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES- CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssev 69 LdvGcGtG+++ +a+++ + v++v+ s+ + + + + ++g+ +++ ++ +e++ +p+ ++D+ vs ++ tr|B7U632|B7U632_HUMAN 142 LDVGCGTGIISLFCAHYArpRAVYAVEASEMAQHTG-QLVLQNGFadiITVYQQKVEDVVLPE-KVDVLVSEWM 213 8**************88899*******777666444.44444455588999*******99999.9***999875 PP >> tr|B7U630|B7U630_HUMAN PRMT2 alpha variant OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.4 0.0 1.4e-06 0.00071 1 69 [. 142 213 .. 142 241 .. 0.76 Alignments for each domain: == domain 1 score: 22.4 bits; conditional E-value: 1.4e-06 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES- CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssev 69 LdvGcGtG+++ +a+++ + v++v+ s+ + + + + ++g+ +++ ++ +e++ +p+ ++D+ vs ++ tr|B7U630|B7U630_HUMAN 142 LDVGCGTGIISLFCAHYArpRAVYAVEASEMAQHTG-QLVLQNGFadiITVYQQKVEDVVLPE-KVDVLVSEWM 213 8**************88899*******777666444.44444455588999*******99999.9*****9985 PP >> tr|J3KP72|J3KP72_HUMAN Protein-L-isoaspartate O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.3 0.1 3e-06 0.0015 1 93 [. 141 237 .. 141 239 .. 0.80 Alignments for each domain: == domain 1 score: 21.3 bits; conditional E-value: 3e-06 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT-.......EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseegl.......vefvvadaeklpfpdnsfDlvvssevlhhvedpe 77 LdvG+G+G+l++ +a+ + ++v+g+D +e+++ + ++++++++ v++vv+d + +++ +D++ + ++ v+ tr|J3KP72|J3KP72_HUMAN 141 LDVGSGSGILTACFARMVgctGKVIGIDHIKELVDDSVNNVRKDDPtllssgrVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVP--- 224 8**************88889**************9888888888878999***999*****96455567999998887766663... PP HHHHHHHHHEEEEEEE CS Methyltransf_11 78 kalkeiaRvLkpgGll 93 + + LkpgG+l tr|J3KP72|J3KP72_HUMAN 225 ---QALIDQLKPGGRL 237 ...2333345666665 PP >> tr|H7BY58|H7BY58_HUMAN Protein-L-isoaspartate O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.3 0.1 3e-06 0.0015 1 93 [. 141 237 .. 141 239 .. 0.80 Alignments for each domain: == domain 1 score: 21.3 bits; conditional E-value: 3e-06 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT-.......EEETTEECCCTSS-TT-EEEEEEES-CCC-CCHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseegl.......vefvvadaeklpfpdnsfDlvvssevlhhvedpe 77 LdvG+G+G+l++ +a+ + ++v+g+D +e+++ + ++++++++ v++vv+d + +++ +D++ + ++ v+ tr|H7BY58|H7BY58_HUMAN 141 LDVGSGSGILTACFARMVgctGKVIGIDHIKELVDDSVNNVRKDDPtllssgrVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVP--- 224 8**************88889**************9888888888878999***999*****96455567999998887766663... PP HHHHHHHHHEEEEEEE CS Methyltransf_11 78 kalkeiaRvLkpgGll 93 + + LkpgG+l tr|H7BY58|H7BY58_HUMAN 225 ---QALIDQLKPGGRL 237 ...2333345666665 PP >> tr|A8MXR3|A8MXR3_HUMAN Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.9 0.0 2e-06 0.001 1 69 [. 142 213 .. 142 224 .. 0.82 Alignments for each domain: == domain 1 score: 21.9 bits; conditional E-value: 2e-06 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES- CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssev 69 LdvGcGtG+++ +a+++ + v++v+ s+ + + + + ++g+ +++ ++ +e++ +p+ ++D+ vs ++ tr|A8MXR3|A8MXR3_HUMAN 142 LDVGCGTGIISLFCAHYArpRAVYAVEASEMAQHTG-QLVLQNGFadiITVYQQKVEDVVLPE-KVDVLVSEWM 213 8**************88899*******777666444.44444455588999*******99999.9***999875 PP >> tr|B3KR83|B3KR83_HUMAN Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.7 0.1 2.3e-06 0.0012 1 31 [. 81 111 .. 81 115 .. 0.97 Alignments for each domain: == domain 1 score: 21.7 bits; conditional E-value: 2.3e-06 EEET-TTSHHHHHHHHTTSEEEEEES-HHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspeml 31 Ld+GcGtG+ +l + g+ vg+D+sp+ml tr|B3KR83|B3KR83_HUMAN 81 LDIGCGTGLSGSYLSDEGHYWVGLDISPAML 111 8****************************98 PP >> sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member 1 OS=Homo sapiens GN=HEMK1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.5 0.0 2.7e-06 0.0014 1 83 [. 164 255 .. 164 258 .. 0.82 Alignments for each domain: == domain 1 score: 21.5 bits; conditional E-value: 2.7e-06 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCC....TSS-TT-EEEEEEES-CCC-CCHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaek....lpfpdnsfDlvvssevlhhvedpeka 79 L+vGcG+G+++ l + +rv++vD ++++ l +e+a++ +l + +++ d+++ + +p + +Dl+vs+ + +d+e++ sp|Q9Y5R4|HEMK1_HUMAN 164 LEVGCGSGAISLSLLSQLpqSRVIAVDKREAAISLTHENAQRLRLqdrIWIIHLDMTSerswTHLPWGPMDLIVSNPPYVFHQDMEQL 251 89*************8888*****************9999999999996668888885556667888889999999755555566666 PP HHHH CS Methyltransf_11 80 lkei 83 ei sp|Q9Y5R4|HEMK1_HUMAN 252 APEI 255 6665 PP >> tr|H7C1L4|H7C1L4_HUMAN Methyltransferase-like protein 6 (Fragment) OS=Homo sapiens GN=METTL6 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.3 0.1 1.5e-06 0.00076 55 93 .. 14 54 .. 2 56 .. 0.84 Alignments for each domain: == domain 1 score: 22.3 bits; conditional E-value: 1.5e-06 SS-TT-EEEEEEES-CCC-..CCHHHHHHHHHHHEEEEEEE CS Methyltransf_11 55 pfpdnsfDlvvssevlhhv..edpekalkeiaRvLkpgGll 93 +p +s+D+v++ +vl v ++++ +l++i++vLkpg + tr|H7C1L4|H7C1L4_HUMAN 14 HVPPESVDVVMLIFVLSAVhpDKMHLVLQNIYKVLKPGKSV 54 58899**************9889999***********9655 PP >> sp|P55345-2|ANM2_HUMAN Isoform 2 of Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.6 0.0 2.5e-06 0.0013 1 69 [. 142 213 .. 142 222 .. 0.82 Alignments for each domain: == domain 1 score: 21.6 bits; conditional E-value: 2.5e-06 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES- CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssev 69 LdvGcGtG+++ +a+++ + v++v+ s+ + + + + ++g+ +++ ++ +e++ +p+ ++D+ vs ++ sp|P55345-2|ANM2_HUMAN 142 LDVGCGTGIISLFCAHYArpRAVYAVEASEMAQHTG-QLVLQNGFadiITVYQQKVEDVVLPE-KVDVLVSEWM 213 8**************88899*******777666444.44444455588999*******99999.9***999875 PP >> sp|P55345|ANM2_HUMAN Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.4 0.0 2.9e-06 0.0015 1 69 [. 142 213 .. 142 241 .. 0.77 Alignments for each domain: == domain 1 score: 21.4 bits; conditional E-value: 2.9e-06 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES- CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssev 69 LdvGcGtG+++ +a+++ + v++v+ s+ + + + + ++g+ +++ ++ +e++ +p+ ++D+ vs ++ sp|P55345|ANM2_HUMAN 142 LDVGCGTGIISLFCAHYArpRAVYAVEASEMAQHTG-QLVLQNGFadiITVYQQKVEDVVLPE-KVDVLVSEWM 213 8**************88899*******777666444.44444455588999*******99999.9*****9985 PP >> sp|P55345-3|ANM2_HUMAN Isoform 3 of Protein arginine N-methyltransferase 2 OS=Homo sapiens GN=PRMT2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.2 0.0 3.3e-06 0.0017 1 69 [. 142 213 .. 142 223 .. 0.82 Alignments for each domain: == domain 1 score: 21.2 bits; conditional E-value: 3.3e-06 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES- CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssev 69 LdvGcGtG+++ +a+++ + v++v+ s+ + + + + ++g+ +++ ++ +e++ +p+ ++D+ vs ++ sp|P55345-3|ANM2_HUMAN 142 LDVGCGTGIISLFCAHYArpRAVYAVEASEMAQHTG-QLVLQNGFadiITVYQQKVEDVVLPE-KVDVLVSEWM 213 8**************88899*******777666444.44444455588999*******99999.9***999875 PP >> sp|P49327|FAS_HUMAN Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.7 0.0 9.7e-06 0.0049 19 94 .. 1268 1343 .. 1247 1344 .. 0.85 Alignments for each domain: == domain 1 score: 19.7 bits; conditional E-value: 9.7e-06 SEEEEEES-HHHHHHHHHHCCHHT-EEETTEECCC.TSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 19 arvvgvDlspemlklakekaseeglvefvvadaek.lpfpdnsfDlvvssevlhhvedpekalkeiaRvLkpgGllv 94 +++++D p++l++a+++ ++ + v + d + p + +s Dl v++ ++ + dp++al++++ L+ gG+l+ sp|P49327|FAS_HUMAN 1268 LSYTATDRHPQALEAAQAELQQHD-VAQGQWDPADpAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGGFLL 1343 4799*****************999.54445555552477779********************************997 PP >> tr|F2Z2W7|F2Z2W7_HUMAN tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.6 0.2 2.1e-05 0.01 8 55 .. 462 512 .. 437 517 .. 0.76 Alignments for each domain: == domain 1 score: 18.6 bits; conditional E-value: 2.1e-05 SHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT.S CS Methyltransf_11 8 GrlaealakrgarvvgvDlspemlklakekaseegl..vefvvadaekl.p 55 Gr+ + l ++++rv+gv+l+pe+++ a+ +a++++l vef++++ae+l p tr|F2Z2W7|F2Z2W7_HUMAN 462 GRHHAFLFQKVKRVIGVELCPEAVEDARVNAQDNELsnVEFHCGRAEDLvP 512 44444555667***********************99***********9855 PP >> tr|H7C3H9|H7C3H9_HUMAN Methyltransferase-like protein 6 (Fragment) OS=Homo sapiens GN=METTL6 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.1 0.0 1.4e-05 0.0073 21 85 .. 13 84 .. 3 86 .. 0.84 Alignments for each domain: == domain 1 score: 19.1 bits; conditional E-value: 1.4e-05 EEEEES-HHHHHHHHHHCCHHT-.EEETTEECCC...T.SS-TT-EEEEEEES-CCC-..CCHHHHHHHHHH CS Methyltransf_11 21 vvgvDlspemlklakekaseegl.vefvvadaek...l.pfpdnsfDlvvssevlhhv..edpekalkeiaR 85 +++D+sp++++++k++ + + +++ ++d++k l +p +s+D+v++ +vl v ++++ +l++i++ tr|H7C3H9|H7C3H9_HUMAN 13 AYACDFSPRAIEYVKQNPLYDTErCKVFQCDLTKddlLdHVPPESVDVVMLIFVLSAVhpDKMHLVLQNIYK 84 689***********998777777888899999976766679*****************87778888888876 PP >> sp|O95671-3|ASML_HUMAN Isoform 3 of N-acetylserotonin O-methyltransferase-like protein OS=Homo sapiens GN=ASMTL # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.5 0.0 2.2e-05 0.011 2 91 .. 399 492 .. 398 496 .. 0.89 Alignments for each domain: == domain 1 score: 18.5 bits; conditional E-value: 2.2e-05 EET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHH CS Methyltransf_11 2 dvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalk 81 dvG +tG+la++la+ + ++v+ +Dl p ++la + +++ + + f +d+ + p+p+ l v+ lh + ++++k+l+ sp|O95671-3|ASML_HUMAN 399 DVGGCTGALARELAREYprMQVTVFDL-PDIIELAAHFQPPGPQavqIHFAAGDFFRDPLPS--AELYVLCRILHDWpdDKVHKLLS 482 9*************9999********6.9999999888887777999999999999989987..889999999999999899***** PP HHHHHEEEEE CS Methyltransf_11 82 eiaRvLkpgG 91 +a +kpg sp|O95671-3|ASML_HUMAN 483 RVAESCKPGA 492 ********96 PP >> tr|E7ER97|E7ER97_HUMAN N-acetylserotonin O-methyltransferase-like protein OS=Homo sapiens GN=ASMTL PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.6 0.0 2.1e-05 0.011 2 91 .. 381 474 .. 380 478 .. 0.89 Alignments for each domain: == domain 1 score: 18.6 bits; conditional E-value: 2.1e-05 EET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHH CS Methyltransf_11 2 dvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalk 81 dvG +tG+la++la+ + ++v+ +Dl p ++la + +++ + + f +d+ + p+p+ l v+ lh + ++++k+l+ tr|E7ER97|E7ER97_HUMAN 381 DVGGCTGALARELAREYprMQVTVFDL-PDIIELAAHFQPPGPQavqIHFAAGDFFRDPLPS--AELYVLCRILHDWpdDKVHKLLS 464 9*************9999********6.9999999888887777999999999999989987..889999999999999899***** PP HHHHHEEEEE CS Methyltransf_11 82 eiaRvLkpgG 91 +a +kpg tr|E7ER97|E7ER97_HUMAN 465 RVAESCKPGA 474 ********96 PP >> sp|P40261|NNMT_HUMAN Nicotinamide N-methyltransferase OS=Homo sapiens GN=NNMT PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 15.4 0.0 0.00021 0.11 2 95 .] 61 195 .. 60 195 .. 0.78 Alignments for each domain: == domain 1 score: 15.4 bits; conditional E-value: 0.00021 EET-TTSHHHHHHH.HTTSEEEEEES-HHHHHHHHHHCCHHT-.......EEE.........................TTEECCC.... CS Methyltransf_11 2 dvGcGtGrlaeala.krgarvvgvDlspemlklakekaseegl.......vef.........................vvadaek.... 53 d+G+G +++ a + ++++v +D+s++ l+ ++ ++e++ v++ +++d+++ sp|P40261|NNMT_HUMAN 61 DIGSGPTIYQLLSAcESFKEIVVTDYSDQNLQELEKWLKKEPEafdwspvVTYvcdlegnrvkgpekeeklrqavkqvLKCDVTQsqpl 149 89999887777777566699999999999999999999988888555555333888899999999999999999999988888864342 PP ..TSS-TT-EEEEEEES-CCC-....CCHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 54 ..lpfpdnsfDlvvssevlhhv....edpekalkeiaRvLkpgGllvi 95 +p+p D+v+s+ +l+ + +al+++ +LkpgG+lvi sp|P40261|NNMT_HUMAN 150 gaVPLP--PADCVLSTLCLDAAcpdlPTYCRALRNLGSLLKPGGFLVI 195 224555..59**********999766677899999999*******996 PP >> sp|Q96RS0|TGS1_HUMAN Trimethylguanosine synthase OS=Homo sapiens GN=TGS1 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.5 0.0 2.3e-05 0.012 3 64 .. 697 760 .. 695 763 .. 0.85 Alignments for each domain: == domain 1 score: 18.5 bits; conditional E-value: 2.3e-05 ET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCT.SS-TT-EEEE CS Methyltransf_11 3 vGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...vefvvadaekl.pfpdnsfDlv 64 + cG G ++ ++a +g+rv+++D++p ++la+++a+ g+ +ef+++d+ l f + D+v sp|Q96RS0|TGS1_HUMAN 697 AFCGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIadkIEFICGDFLLLaSFLK--ADVV 760 55***********************************99999********9986644544..5555 PP >> sp|O95671-2|ASML_HUMAN Isoform 2 of N-acetylserotonin O-methyltransferase-like protein OS=Homo sapiens GN=ASMTL # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.4 0.0 2.5e-05 0.013 2 91 .. 441 534 .. 440 538 .. 0.89 Alignments for each domain: == domain 1 score: 18.4 bits; conditional E-value: 2.5e-05 EET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHH CS Methyltransf_11 2 dvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalk 81 dvG +tG+la++la+ + ++v+ +Dl p ++la + +++ + + f +d+ + p+p+ l v+ lh + ++++k+l+ sp|O95671-2|ASML_HUMAN 441 DVGGCTGALARELAREYprMQVTVFDL-PDIIELAAHFQPPGPQavqIHFAAGDFFRDPLPS--AELYVLCRILHDWpdDKVHKLLS 524 9*************9999********6.9999999888887777999999999999989987..889999999999999899***** PP HHHHHEEEEE CS Methyltransf_11 82 eiaRvLkpgG 91 +a +kpg sp|O95671-2|ASML_HUMAN 525 RVAESCKPGA 534 ********96 PP >> sp|O95671|ASML_HUMAN N-acetylserotonin O-methyltransferase-like protein OS=Homo sapiens GN=ASMTL PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.3 0.0 2.6e-05 0.013 2 91 .. 457 550 .. 456 554 .. 0.89 Alignments for each domain: == domain 1 score: 18.3 bits; conditional E-value: 2.6e-05 EET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHHHH CS Methyltransf_11 2 dvGcGtGrlaealakrg..arvvgvDlspemlklakekaseegl...vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalkei 83 dvG +tG+la++la+ + ++v+ +Dl p ++la + +++ + + f +d+ + p+p+ l v+ lh + ++++k+l+ + sp|O95671|ASML_HUMAN 457 DVGGCTGALARELAREYprMQVTVFDL-PDIIELAAHFQPPGPQavqIHFAAGDFFRDPLPS--AELYVLCRILHDWpdDKVHKLLSRV 542 9*************9999********6.9999999888887777999999999999989987..889999999999999899******* PP HHHEEEEE CS Methyltransf_11 84 aRvLkpgG 91 a +kpg sp|O95671|ASML_HUMAN 543 AESCKPGA 550 ******96 PP >> tr|H7C258|H7C258_HUMAN HemK methyltransferase family member 1 (Fragment) OS=Homo sapiens GN=HEMK1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.9 0.0 3.6e-05 0.018 1 40 [. 2 43 .. 2 66 .. 0.85 Alignments for each domain: == domain 1 score: 17.9 bits; conditional E-value: 3.6e-05 EEET-TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCH CS Methyltransf_11 1 LdvGcGtGrlaealakrg..arvvgvDlspemlklakekase 40 L+vGcG+G+++ l + +rv++vD ++++ l +e+a+ tr|H7C258|H7C258_HUMAN 2 LEVGCGSGAISLSLLSQLpqSRVIAVDKREAAISLTHENAQS 43 89*************8888**************988888775 PP >> sp|Q7Z624|CMKMT_HUMAN Calmodulin-lysine N-methyltransferase OS=Homo sapiens GN=CAMKMT PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 17.8 0.0 3.7e-05 0.019 11 94 .. 165 258 .. 152 259 .. 0.71 Alignments for each domain: == domain 1 score: 17.8 bits; conditional E-value: 3.7e-05 HHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-.............EEE.TTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHH CS Methyltransf_11 11 aealakrgarvvgvDlspemlklakekaseegl.............vef.vvadaeklpfpdnsfDlvvssevlhhvedpekalkeia 84 ++ a +++v+ +D ++++++ +++ + +++ +++ + d++ ++ fD+v++ +l+ + ++++++ i+ sp|Q7Z624|CMKMT_HUMAN 165 VAISA-DVKEVLLTDGNEKAIRNVQDIITRNQKagvfktqkisscvLRWdNETDVS---QLEGHFDIVMCADCLFLDQYRASLVDAIK 248 33333.55788888888888888877666666666666666554322224444444...4578************99*********** PP HHEEEEEEEE CS Methyltransf_11 85 RvLkpgGllv 94 R+L+p G+ + sp|Q7Z624|CMKMT_HUMAN 249 RLLQPRGKAM 258 *******986 PP >> tr|H0YIW7|H0YIW7_HUMAN Methyltransferase-like protein 25 (Fragment) OS=Homo sapiens GN=METTL25 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 17.1 0.0 6.1e-05 0.031 2 42 .. 139 180 .. 138 189 .. 0.87 Alignments for each domain: == domain 1 score: 17.1 bits; conditional E-value: 6.1e-05 EET-TTSHHHHHHH.HTTSEEEEEES-HHHHHHHHHHCCHHT CS Methyltransf_11 2 dvGcGtGrlaeala.krgarvvgvDlspemlklakekaseeg 42 d+G+G+G+l+ l k+g +v+g+D s++ + a+e++++ + tr|H0YIW7|H0YIW7_HUMAN 139 DLGSGKGYLSSFLSlKYGLKVYGIDSSNTNTHGAEERNRKLK 180 9*************7777*************99999888765 PP >> tr|F8VZA8|F8VZA8_HUMAN Methyltransferase-like protein 25 (Fragment) OS=Homo sapiens GN=METTL25 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 17.0 0.0 6.9e-05 0.035 2 42 .. 180 221 .. 179 235 .. 0.85 Alignments for each domain: == domain 1 score: 17.0 bits; conditional E-value: 6.9e-05 EET-TTSHHHHHHH.HTTSEEEEEES-HHHHHHHHHHCCHHT CS Methyltransf_11 2 dvGcGtGrlaeala.krgarvvgvDlspemlklakekaseeg 42 d+G+G+G+l+ l k+g +v+g+D s++ + a+e++++ + tr|F8VZA8|F8VZA8_HUMAN 180 DLGSGKGYLSSFLSlKYGLKVYGIDSSNTNTHGAEERNRKLK 221 9*************7777*************99999988776 PP >> sp|Q8N6Q8|MET25_HUMAN Methyltransferase-like protein 25 OS=Homo sapiens GN=METTL25 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.4 0.0 0.00022 0.11 2 43 .. 180 222 .. 179 262 .. 0.87 Alignments for each domain: == domain 1 score: 15.4 bits; conditional E-value: 0.00022 EET-TTSHHHHHHH.HTTSEEEEEES-HHHHHHHHHHCCHHT- CS Methyltransf_11 2 dvGcGtGrlaeala.krgarvvgvDlspemlklakekaseegl 43 d+G+G+G+l+ l k+g +v+g+D s++ + a+e++++ + sp|Q8N6Q8|MET25_HUMAN 180 DLGSGKGYLSSFLSlKYGLKVYGIDSSNTNTHGAEERNRKLKK 222 9*************7777*************999999888764 PP >> tr|H7C100|H7C100_HUMAN tRNA (uracil-5-)-methyltransferase homolog A (Fragment) OS=Homo sapiens GN=TRMT2A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.7 0.0 8.3e-05 0.042 19 55 .. 3 42 .. 1 54 [. 0.93 Alignments for each domain: == domain 1 score: 16.7 bits; conditional E-value: 8.3e-05 SEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT.S CS Methyltransf_11 19 arvvgvDlspemlklakekaseegl..vefvvadaekl.p 55 +rv+gv+l+pe+++ a+ +a++++l vef++++ae+l p tr|H7C100|H7C100_HUMAN 3 KRVIGVELCPEAVEDARVNAQDNELsnVEFHCGRAEDLvP 42 69*********************99***********9855 PP >> tr|C9J0F2|C9J0F2_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase (Fragment) OS=Homo sapiens GN=PCMT1 P # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 17.0 0.1 6.9e-05 0.035 1 38 [. 52 92 .. 52 96 .] 0.87 Alignments for each domain: == domain 1 score: 17.0 bits; conditional E-value: 6.9e-05 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHC CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakeka 38 LdvG+G+G+l++ +a+ + ++v+g+D +e+++ + +++ tr|C9J0F2|C9J0F2_HUMAN 52 LDVGSGSGILTACFARMVgctGKVIGIDHIKELVDDSVNNV 92 8**************88889**********99997665555 PP >> sp|Q7Z5W3|BN3D2_HUMAN Pre-miRNA 5'-monophosphate methyltransferase OS=Homo sapiens GN=BCDIN3D PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.5 0.0 0.00085 0.43 1 91 [. 71 214 .. 71 216 .. 0.73 Alignments for each domain: == domain 1 score: 13.5 bits; conditional E-value: 0.00085 EEET-TTSHHHHHHH.........HTT......SEEEEEES-HHHHHHHHHHCCHHT-.....EEETTEECCC......T.SS-TT-E CS Methyltransf_11 1 LdvGcGtGrlaeala.........krg......arvvgvDlspemlklakekaseegl.....vefvvadaek......l.pfpdnsf 61 LdvGc +G l+ al +++ r++++D++p ++k+a+++ + ++ ++f+ ++ +k l +f + f sp|Q7Z5W3|BN3D2_HUMAN 71 LDVGCNSGDLSVALYkhflslpdgETCsdasreFRLLCCDIDPVLVKRAEKECPFPDAltfitLDFMNQRTRKvllssfLsQFGRSVF 158 89**********9997776666663336667889***************9999999996776655544444444444455589999** PP EEEEEES-CCC-C..........................CHHHHHHHHHHHEEEEE CS Methyltransf_11 62 Dlvvssevlhhve..........................dpekalkeiaRvLkpgG 91 D+ ++ + ++++ +p k+ + +aR L++ G sp|Q7Z5W3|BN3D2_HUMAN 159 DIGFCMSITMWIHlnhgdhglweflahlsslchyllvepQPWKCYRAAARRLRKLG 214 *****999999955566667777777777777777777777777777777776655 PP >> sp|A6NDL7|MT21E_HUMAN Putative methyltransferase-like protein 21E pseudogene OS=Homo sapiens GN=METTL21EP PE=5 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.8 0.0 0.00015 0.078 2 73 .. 122 203 .. 121 222 .. 0.80 Alignments for each domain: == domain 1 score: 15.8 bits; conditional E-value: 0.00015 EET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...........EEETTEECCCTSS-TT-EEEEEEES-CCC- CS Methyltransf_11 2 dvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...........vefvvadaeklpfpdnsfDlvvssevlhhv 73 ++G+GtG+++ ga+v+++Dl pe+l + ++s++ +++ va +++p +n fD +++ v+ sp|A6NDL7|MT21E_HUMAN 122 EIGAGTGLVSIVASLLGAHVTATDL-PELLGNLQYNISRNTKmkskhlpqvkeLSWGVALDTNFPRSSNNFDYILAADVVYAH 203 89**********************7.7777555555555544555556778889999999999*************9998655 PP >> tr|B3KU92|B3KU92_HUMAN Putative protein arginine N-methyltransferase 10 OS=Homo sapiens GN=LOC90826 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.6 0.0 0.00037 0.19 1 38 [. 69 107 .. 69 135 .. 0.81 Alignments for each domain: == domain 1 score: 14.6 bits; conditional E-value: 0.00037 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHC CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakeka 38 Ld+G+GtG+l+ +k g ++v++++ls++m +la + + tr|B3KU92|B3KU92_HUMAN 69 LDIGAGTGILSMFAKKAGaHSVYACELSKTMYELACDVV 107 8*******************************9884444 PP >> tr|H7C4Z8|H7C4Z8_HUMAN Methyltransferase-like protein 2B (Fragment) OS=Homo sapiens GN=METTL2B PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.0 0.0 0.00028 0.14 1 42 [. 179 224 .. 179 233 .. 0.84 Alignments for each domain: == domain 1 score: 15.0 bits; conditional E-value: 0.00028 EEET-TTSHHHHHHHHTT....SEEEEEES-HHHHHHHHHHCCHHT CS Methyltransf_11 1 LdvGcGtGrlaealakrg....arvvgvDlspemlklakekaseeg 42 L+vGcG G + ++ ++ v+++D+s ++++l++++++ ++ tr|H7C4Z8|H7C4Z8_HUMAN 179 LEVGCGVGNTVFPILQTNndpgLFVYCCDFSSTAIELVQTNSEYDP 224 89**********9995445566****************99988776 PP >> sp|Q6P2P2|ANM10_HUMAN Putative protein arginine N-methyltransferase 10 OS=Homo sapiens GN=PRMT10 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.4 0.0 0.00044 0.22 1 38 [. 182 220 .. 182 248 .. 0.82 Alignments for each domain: == domain 1 score: 14.4 bits; conditional E-value: 0.00044 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHC CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakeka 38 Ld+G+GtG+l+ +k g ++v++++ls++m +la + + sp|Q6P2P2|ANM10_HUMAN 182 LDIGAGTGILSMFAKKAGaHSVYACELSKTMYELACDVV 220 8*******************************9884444 PP >> sp|Q96GJ1-3|TRM2_HUMAN Isoform 3 of tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Homo sapiens GN=TRMT2B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.8 0.0 0.00033 0.17 1 54 [. 304 359 .. 304 371 .. 0.88 Alignments for each domain: == domain 1 score: 14.8 bits; conditional E-value: 0.00033 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl..vefvvadaekl 54 Ld+ cGtG + la++ +rv+g++l +++++ a+ a +g+ ef+ + aek+ sp|Q96GJ1-3|TRM2_HUMAN 304 LDICCGTGVIGLSLAQHTSRVLGIELLEQAVEDARWTAAFNGItnSEFHTGQAEKI 359 89*************999*************9998888777777899999999985 PP >> sp|Q96GJ1-2|TRM2_HUMAN Isoform 2 of tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Homo sapiens GN=TRMT2B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.6 0.0 0.00037 0.19 1 54 [. 349 404 .. 349 416 .. 0.88 Alignments for each domain: == domain 1 score: 14.6 bits; conditional E-value: 0.00037 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl..vefvvadaekl 54 Ld+ cGtG + la++ +rv+g++l +++++ a+ a +g+ ef+ + aek+ sp|Q96GJ1-2|TRM2_HUMAN 349 LDICCGTGVIGLSLAQHTSRVLGIELLEQAVEDARWTAAFNGItnSEFHTGQAEKI 404 89*************999*************9998888777777899999999985 PP >> tr|F2Z384|F2Z384_HUMAN tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Homo sapiens GN=TRMT2B PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.6 0.0 0.00037 0.19 1 54 [. 349 404 .. 349 416 .. 0.88 Alignments for each domain: == domain 1 score: 14.6 bits; conditional E-value: 0.00037 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl..vefvvadaekl 54 Ld+ cGtG + la++ +rv+g++l +++++ a+ a +g+ ef+ + aek+ tr|F2Z384|F2Z384_HUMAN 349 LDICCGTGVIGLSLAQHTSRVLGIELLEQAVEDARWTAAFNGItnSEFHTGQAEKI 404 89*************999*************9998888777777899999999985 PP >> sp|Q96GJ1|TRM2_HUMAN tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Homo sapiens GN=TRMT2B PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.6 0.0 0.00038 0.19 1 54 [. 349 404 .. 349 416 .. 0.88 Alignments for each domain: == domain 1 score: 14.6 bits; conditional E-value: 0.00038 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECCCT CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl..vefvvadaekl 54 Ld+ cGtG + la++ +rv+g++l +++++ a+ a +g+ ef+ + aek+ sp|Q96GJ1|TRM2_HUMAN 349 LDICCGTGVIGLSLAQHTSRVLGIELLEQAVEDARWTAAFNGItnSEFHTGQAEKI 404 89*************999*************9998888777777899999999985 PP >> tr|E9PMW9|E9PMW9_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.4 0.0 0.00086 0.44 1 28 [. 69 97 .. 69 110 .] 0.83 Alignments for each domain: == domain 1 score: 13.4 bits; conditional E-value: 0.00086 EEET-TTSHHHHHHHHTT.SEEEEEES-H CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlsp 28 LdvG+GtG+l+ ak g ++v+g++ s tr|E9PMW9|E9PMW9_HUMAN 69 LDVGSGTGILCMFAAKAGaRKVIGIECSS 97 8***********************99765 PP >> tr|H0Y768|H0Y768_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog (Fragment) OS=Homo sapiens GN=TRMT11 PE=4 SV= # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.7 0.0 0.00034 0.17 5 67 .. 23 89 .. 19 107 .. 0.79 Alignments for each domain: == domain 1 score: 14.7 bits; conditional E-value: 0.00034 -TTSHHHHHHHHTTSEEEEEES-HHHH....HHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEE CS Methyltransf_11 5 cGtGrlaealakrgarvvgvDlspeml....klakekaseeglvefvvadaeklpfpdnsfDlvvss 67 +GtG l+ a+a+ ga v+g+D++ +++ k+ +++++ +g+ e ++a++++ +++ + D+ vs tr|H0Y768|H0Y768_HUMAN 23 VGTGGLLIACAHFGAYVYGTDIDYNTVhglgKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSD 89 699********9***************5555444555544444666899999999999999988875 PP >> tr|F5H2D9|F5H2D9_HUMAN mRNA cap guanine-N7 methyltransferase OS=Homo sapiens GN=RNMT PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.1 0.0 0.0011 0.58 56 94 .. 29 73 .. 2 74 .. 0.78 Alignments for each domain: == domain 1 score: 13.1 bits; conditional E-value: 0.0011 S-T..T-EEEEEEES-CCC-....CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 56 fpd..nsfDlvvssevlhhv....edpekalkeiaRvLkpgGllv 94 f+d fD++ +++v h+ e+ + l+++ L pgG+++ tr|F5H2D9|F5H2D9_HUMAN 29 FRDpqMCFDICSCQFVCHYSfesyEQADMMLRNACERLSPGGYFI 73 5553258************9999889999**************97 PP >> tr|E9PI83|E9PI83_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.4 0.0 0.00091 0.46 1 28 [. 72 100 .. 72 113 .] 0.83 Alignments for each domain: == domain 1 score: 13.4 bits; conditional E-value: 0.00091 EEET-TTSHHHHHHHHTT.SEEEEEES-H CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlsp 28 LdvG+GtG+l+ ak g ++v+g++ s tr|E9PI83|E9PI83_HUMAN 72 LDVGSGTGILCMFAAKAGaRKVIGIECSS 100 8***********************99765 PP >> sp|P51580|TPMT_HUMAN Thiopurine S-methyltransferase OS=Homo sapiens GN=TPMT PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.6 0.0 0.00077 0.39 5 72 .. 70 157 .. 68 171 .. 0.74 Alignments for each domain: == domain 1 score: 13.6 bits; conditional E-value: 0.00077 -TTSHHHHHHHHTTSEEEEEES-HHHHHHH....HHHCCHHT-.................EEETTEECCCTSS-T.T-EEEEEEES-CC CS Methyltransf_11 5 cGtGrlaealakrgarvvgvDlspemlkla....kekaseegl.................vefvvadaeklpfpd.nsfDlvvssevlh 71 cG+ ++++a+rg++vvgv++s+ ++ + +se + +++ ++++ +lp + ++fD+++ + +l sp|P51580|TPMT_HUMAN 70 CGKAVEMKWFADRGHSVVGVEISELGIQEFfteqNLSYSE--EpiteipgtkvfksssgnISLYCCSIFDLPRTNiGKFDMIWDRGALV 156 9**************************6553422333333..24467677666666666666699999999855558999999888775 PP C CS Methyltransf_11 72 h 72 sp|P51580|TPMT_HUMAN 157 A 157 5 PP >> sp|O95050-2|INMT_HUMAN Isoform 2 of Indolethylamine N-methyltransferase OS=Homo sapiens GN=INMT # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.7 0.0 0.003 1.5 54 94 .. 153 193 .. 59 194 .. 0.81 Alignments for each domain: == domain 1 score: 11.7 bits; conditional E-value: 0.003 TSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 54 lpfpdnsfDlvvssevlhhvedpekalkeiaRvLkpgGllv 94 lp++d l + + + ++ ++al ++a +LkpgG+lv sp|O95050-2|INMT_HUMAN 153 LPLADCVLTLLAMECACCSLDAYRAALCNLASLLKPGGHLV 193 68888888888888899999*******************98 PP >> sp|O95050|INMT_HUMAN Indolethylamine N-methyltransferase OS=Homo sapiens GN=INMT PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.7 0.0 0.0031 1.6 54 94 .. 154 194 .. 60 195 .. 0.81 Alignments for each domain: == domain 1 score: 11.7 bits; conditional E-value: 0.0031 TSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 54 lpfpdnsfDlvvssevlhhvedpekalkeiaRvLkpgGllv 94 lp++d l + + + ++ ++al ++a +LkpgG+lv sp|O95050|INMT_HUMAN 154 LPLADCVLTLLAMECACCSLDAYRAALCNLASLLKPGGHLV 194 68888888888888899999*******************98 PP >> sp|Q9Y5N5|HEMK2_HUMAN HemK methyltransferase family member 2 OS=Homo sapiens GN=N6AMT1 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.9 0.0 0.0006 0.31 1 64 [. 50 119 .. 50 123 .. 0.75 Alignments for each domain: == domain 1 score: 13.9 bits; conditional E-value: 0.0006 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT-.EEETTEECCC..TSS-TT-EEEE CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseegl.vefvvadaek..lpfpdnsfDlv 64 L+vG+G+G +++ la a ++++D++pe+ ++ e a+ +++ ++ v d+ k lp +++Dl sp|Q9Y5N5|HEMK2_HUMAN 50 LEVGSGSGVVSAFLASMIgpqALYMCTDINPEAAACTLETARCNKVhIQPVITDLVKglLPRLTEKVDLL 119 89*************6667999************888777766665555566666555446666666665 PP >> tr|A8MT87|A8MT87_HUMAN Phenylethanolamine N-methyltransferase OS=Homo sapiens GN=PNMT PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.7 0.0 0.0007 0.36 61 94 .. 77 114 .. 40 115 .. 0.87 Alignments for each domain: == domain 1 score: 13.7 bits; conditional E-value: 0.0007 EEEEEEES-CCC-....CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 61 fDlvvssevlhhv....edpekalkeiaRvLkpgGllv 94 D+ vs ++l+ v + ++al+ i +L+pgG+l+ tr|A8MT87|A8MT87_HUMAN 77 ADALVSAFCLEAVspdlASFQRALDHITTLLRPGGHLL 114 5999*********988789*****************97 PP >> sp|P11086|PNMT_HUMAN Phenylethanolamine N-methyltransferase OS=Homo sapiens GN=PNMT PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.7 0.0 0.0015 0.77 61 94 .. 175 212 .. 139 213 .. 0.88 Alignments for each domain: == domain 1 score: 12.7 bits; conditional E-value: 0.0015 EEEEEEES-CCC-....CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 61 fDlvvssevlhhv....edpekalkeiaRvLkpgGllv 94 D+ vs ++l+ v + ++al+ i +L+pgG+l+ sp|P11086|PNMT_HUMAN 175 ADALVSAFCLEAVspdlASFQRALDHITTLLRPGGHLL 212 5999*********987789*****************97 PP >> tr|I3L2J5|I3L2J5_HUMAN Methyltransferase-like protein 22 (Fragment) OS=Homo sapiens GN=METTL22 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.1 0.2 0.00053 0.27 1 43 [. 6 48 .. 6 117 .. 0.87 Alignments for each domain: == domain 1 score: 14.1 bits; conditional E-value: 0.00053 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT- CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl 43 L++G+GtG+ + a +++v+++D+ + +l ++++++ + + tr|I3L2J5|I3L2J5_HUMAN 6 LELGAGTGLASIIAATMARTVYCTDVGADLLSMCQRNIALNSH 48 89*************999*****************99987765 PP >> tr|F8WDR2|F8WDR2_HUMAN tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens GN=TRMT61B PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.2 0.0 0.00099 0.5 1 73 [. 251 341 .. 251 358 .. 0.80 Alignments for each domain: == domain 1 score: 13.2 bits; conditional E-value: 0.00099 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT-.............EEETTEECCC.T.SS-TT-EEEEEEES- CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseegl.............vefvvadaek.l.pfpdnsfDlvvssev 69 L++G+G+G ++ l k + +rv+ +++ + ++lak++++ + v+f++ d++ + ++++ +fD+v + + tr|F8WDR2|F8WDR2_HUMAN 251 LEAGSGSGGMSLFLSKAVgsqGRVISFEVRKDHHDLAKKNYKHWRDswklshveewpdnVDFIHKDISGaTeDIKSLTFDAVALDML 337 799************7777999*******************9998888889999999999999999984244688889999977766 PP CCC- CS Methyltransf_11 70 lhhv 73 hv tr|F8WDR2|F8WDR2_HUMAN 338 NPHV 341 5555 PP >> sp|Q8N4J0|CI041_HUMAN UPF0586 protein C9orf41 OS=Homo sapiens GN=C9orf41 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.7 0.0 0.0015 0.74 45 93 .. 290 338 .. 275 340 .. 0.88 Alignments for each domain: == domain 1 score: 12.7 bits; conditional E-value: 0.0015 EETTEECCCTSS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEE CS Methyltransf_11 45 efvvadaeklpfpdnsfDlvvssevlhhvedpekalkeiaRvLkpgGll 93 ++ +d++++ + n+ D++ +++++ +++ ++++ i+++LkpgG+ sp|Q8N4J0|CI041_HUMAN 290 SMTAGDFQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWKILKPGGIW 338 56788999998888*********************************85 PP >> sp|Q6FI81-3|CPIN1_HUMAN Isoform 3 of Anamorsin OS=Homo sapiens GN=CIAPIN1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.3 0.0 0.002 1 76 94 .. 63 81 .. 22 82 .. 0.90 Alignments for each domain: == domain 1 score: 12.3 bits; conditional E-value: 0.002 HHHHHHHHHHHEEEEEEEE CS Methyltransf_11 76 pekalkeiaRvLkpgGllv 94 +++l+eiaR+L+pgG l+ sp|Q6FI81-3|CPIN1_HUMAN 63 SAEILAEIARILRPGGCLF 81 5789************997 PP >> tr|H7C2C8|H7C2C8_HUMAN Methyltransferase-like protein 2B (Fragment) OS=Homo sapiens GN=METTL2B PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.7 0.0 0.00071 0.36 1 35 [. 8 46 .. 8 67 .. 0.85 Alignments for each domain: == domain 1 score: 13.7 bits; conditional E-value: 0.00071 EEET-TTSHHHHHHHHTT....SEEEEEES-HHHHHHHH CS Methyltransf_11 1 LdvGcGtGrlaealakrg....arvvgvDlspemlklak 35 L+vGcG G + ++ ++ v+++D+s ++++l++ tr|H7C2C8|H7C2C8_HUMAN 8 LEVGCGVGNTVFPILQTNndpgLFVYCCDFSSTAIELVQ 46 89**********9995445566************99875 PP >> tr|H3BQW1|H3BQW1_HUMAN Protein FAM173A (Fragment) OS=Homo sapiens GN=FAM173A PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.5 0.0 0.00082 0.42 1 57 [. 2 62 .. 2 66 .. 0.91 Alignments for each domain: == domain 1 score: 13.5 bits; conditional E-value: 0.00082 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS- CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl...vefvvadaeklpfp 57 +d+G+G Gr++ a ++ g + vg +l+p +++la+ +a ++g v +++ d+ klp+ tr|H3BQW1|H3BQW1_HUMAN 2 VDLGSGDGRIVLAAHRCGlRPAVGYELNPWLVALARLHAWRAGCagsVCYRRKDLWKLPLL 62 59*************999**********************999999988999999999964 PP >> sp|Q5VZV1|MT21C_HUMAN Protein-lysine methyltransferase METTL21C OS=Homo sapiens GN=METTL21C PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 0.4 0.0 9.9 5e+03 44 60 .. 99 115 .. 58 116 .. 0.81 2 ? 10.7 0.0 0.0061 3.1 1 93 [. 117 219 .. 117 221 .. 0.69 Alignments for each domain: == domain 1 score: 0.4 bits; conditional E-value: 9.9 EEETTEECCCTSS-TT- CS Methyltransf_11 44 vefvvadaeklpfpdns 60 ++++++ ae+l+f+d++ sp|Q5VZV1|MT21C_HUMAN 99 CQYLEEHAEELNFQDAK 115 7889999999*999975 PP == domain 2 score: 10.7 bits; conditional E-value: 0.0061 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...........EEETTEECCCTSS-TT..-EEEEEEES-CCC-CC CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl...........vefvvadaeklpfpdn..sfDlvvssevlhhved 75 L++G+G G+++ ga+v+++Dl p +l + + ++ l + +d+ k +fp++ ++D v++s v+ h sp|Q5VZV1|MT21C_HUMAN 117 LEIGAGPGLVSIVASILGAQVTATDL-PDVLGNLQYNLLKNTLqctahlpevkeLV-WGEDLDK-NFPKSafYYDYVLASDVVYHHYF 201 89***********99999*******7.55554443333333333344455554332.3334443.555553488*********99999 PP HHHHHHHHHHHEEEEEEE CS Methyltransf_11 76 pekalkeiaRvLkpgGll 93 ++k+l ++ + +pg +l sp|Q5VZV1|MT21C_HUMAN 202 LDKLLTTMVYLSQPGTVL 219 999999998888887655 PP >> tr|F2Z2Q4|F2Z2Q4_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.8 0.0 0.0014 0.72 5 67 .. 224 290 .. 220 307 .. 0.80 Alignments for each domain: == domain 1 score: 12.8 bits; conditional E-value: 0.0014 -TTSHHHHHHHHTTSEEEEEES-HHHH....HHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEE CS Methyltransf_11 5 cGtGrlaealakrgarvvgvDlspeml....klakekaseeglvefvvadaeklpfpdnsfDlvvss 67 +GtG l+ a+a+ ga v+g+D++ +++ k+ +++++ +g+ e ++a++++ +++ + D+ vs tr|F2Z2Q4|F2Z2Q4_HUMAN 224 VGTGGLLIACAHFGAYVYGTDIDYNTVhglgKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSD 290 699********9***************5555444555544444666899999999999999988875 PP >> tr|G3V353|G3V353_HUMAN Methyltransferase-like protein 17, mitochondrial (Fragment) OS=Homo sapiens GN=METTL17 PE=2 S # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.7 0.0 0.0015 0.75 2 39 .. 109 150 .. 108 164 .. 0.84 Alignments for each domain: == domain 1 score: 12.7 bits; conditional E-value: 0.0015 EET-TTSHHHHHHH....HTTSEEEEEES-HHHHHHHHHHCC CS Methyltransf_11 2 dvGcGtGrlaeala....krgarvvgvDlspemlklakekas 39 d+G+GtG+++ a + + +++++vD s++ml la++ + tr|G3V353|G3V353_HUMAN 109 DFGSGTGSVTWAAHsiwgQSLREYMCVDRSAAMLVLAEKLLK 150 99********99996554444*************99987655 PP >> sp|Q9Y5N5-2|HEMK2_HUMAN Isoform 2 of HemK methyltransferase family member 2 OS=Homo sapiens GN=N6AMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.5 0.0 0.0017 0.87 1 42 [. 50 94 .. 50 108 .. 0.80 Alignments for each domain: == domain 1 score: 12.5 bits; conditional E-value: 0.0017 EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHHT CS Methyltransf_11 1 LdvGcGtGrlaealakrg...arvvgvDlspemlklakekaseeg 42 L+vG+G+G +++ la a ++++D++pe+ ++ e a+ ++ sp|Q9Y5N5-2|HEMK2_HUMAN 50 LEVGSGSGVVSAFLASMIgpqALYMCTDINPEAAACTLETARCNK 94 89*************6667999***********977655555544 PP >> tr|H3BNC0|H3BNC0_HUMAN Protein arginine N-methyltransferase 7 OS=Homo sapiens GN=PRMT7 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 7.4 0.0 0.066 34 1 43 [. 69 112 .. 69 134 .. 0.82 2 ? 0.5 0.0 9.1 4.6e+03 75 95 .] 387 407 .. 382 407 .. 0.85 3 ? 0.4 0.0 10 5.1e+03 6 44 .. 409 452 .. 404 466 .. 0.75 Alignments for each domain: == domain 1 score: 7.4 bits; conditional E-value: 0.066 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT- CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl 43 Ld+G GtG+l+ g ++++++ + m ++a + ++++g+ tr|H3BNC0|H3BNC0_HUMAN 69 LDIGTGTGLLSMMAVTAGaDFCYAIEVFKPMADAAVKIVEKNGF 112 8************99999999***********988665555554 PP == domain 2 score: 0.5 bits; conditional E-value: 9.1 CHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 75 dpekalkeiaRvLkpgGllvi 95 + +++++ ++ vLkp+ ++++ tr|H3BNC0|H3BNC0_HUMAN 387 RTDRYVQALRTVLKPDSVCLC 407 568999**********99875 PP == domain 3 score: 0.4 bits; conditional E-value: 10 TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...E CS Methyltransf_11 6 GtGrlaealakrg..arvvgvDlspemlklakekaseegl...v 44 G+l+ la++ ++v++v+ s++ +kl ++ + ++l + tr|H3BNC0|H3BNC0_HUMAN 409 SDGSLLSVLAHHLgvEQVFTVESSAASHKLLRKIFKANHLedkI 452 578889999955559**********9999998877766655554 PP >> sp|Q9NVM4-4|ANM7_HUMAN Isoform 4 of Protein arginine N-methyltransferase 7 OS=Homo sapiens GN=PRMT7 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 7.4 0.0 0.066 34 1 43 [. 69 112 .. 69 134 .. 0.82 2 ? 0.5 0.0 9.1 4.6e+03 75 95 .] 387 407 .. 382 407 .. 0.85 3 ? 0.4 0.0 10 5.1e+03 6 44 .. 409 452 .. 404 466 .. 0.75 Alignments for each domain: == domain 1 score: 7.4 bits; conditional E-value: 0.066 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT- CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl 43 Ld+G GtG+l+ g ++++++ + m ++a + ++++g+ sp|Q9NVM4-4|ANM7_HUMAN 69 LDIGTGTGLLSMMAVTAGaDFCYAIEVFKPMADAAVKIVEKNGF 112 8************99999999***********988665555554 PP == domain 2 score: 0.5 bits; conditional E-value: 9.1 CHHHHHHHHHHHEEEEEEEEE CS Methyltransf_11 75 dpekalkeiaRvLkpgGllvi 95 + +++++ ++ vLkp+ ++++ sp|Q9NVM4-4|ANM7_HUMAN 387 RTDRYVQALRTVLKPDSVCLC 407 568999**********99875 PP == domain 3 score: 0.4 bits; conditional E-value: 10 TTSHHHHHHHHTT..SEEEEEES-HHHHHHHHHHCCHHT-...E CS Methyltransf_11 6 GtGrlaealakrg..arvvgvDlspemlklakekaseegl...v 44 G+l+ la++ ++v++v+ s++ +kl ++ + ++l + sp|Q9NVM4-4|ANM7_HUMAN 409 SDGSLLSVLAHHLgvEQVFTVESSAASHKLLRKIFKANHLedkI 452 578889999955559**********9999998877766655554 PP >> tr|M0R0W0|M0R0W0_HUMAN Methyltransferase-like protein 6 (Fragment) OS=Homo sapiens GN=METTL6 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.2 0.0026 1.3 35 85 .. 74 132 .. 59 134 .. 0.73 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.0026 HHHCCHHT-..EEETTEECCC...T.SS-TT-EEEEEEES-CCC-..CCHHHHHHHHHH CS Methyltransf_11 35 kekaseegl..vefvvadaek...l.pfpdnsfDlvvssevlhhv..edpekalkeiaR 85 +e+++ + +++ ++d++k l +p +s+D+v++ +vl v ++++ +l++i++ tr|M0R0W0|M0R0W0_HUMAN 74 REQNPLYDTerCKVFQCDLTKddlLdHVPPESVDVVMLIFVLSAVhpDKMHLVLQNIYK 132 443333333666778888886665667999***************87778888888876 PP >> tr|F6XBY7|F6XBY7_HUMAN Uncharacterized protein KIAA1456 OS=Homo sapiens GN=KIAA1456 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.3 0.1 0.002 1 2 38 .. 50 84 .. 49 91 .. 0.89 Alignments for each domain: == domain 1 score: 12.3 bits; conditional E-value: 0.002 EET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHC CS Methyltransf_11 2 dvGcGtGrlaealakrgarvvgvDlspemlklakeka 38 d+GcGtG++++ + ++vg+D++ ++++a++++ tr|F6XBY7|F6XBY7_HUMAN 50 DIGCGTGKYLKVNS-Q-VHTVGCDYCGPLVEIARNRG 84 9**********999.3.47**************9987 PP >> sp|Q7Z4G4-2|TRM11_HUMAN Isoform 2 of tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.1 0.0 0.0023 1.2 5 67 .. 224 290 .. 220 307 .. 0.80 Alignments for each domain: == domain 1 score: 12.1 bits; conditional E-value: 0.0023 -TTSHHHHHHHHTTSEEEEEES-HHHH....HHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEE CS Methyltransf_11 5 cGtGrlaealakrgarvvgvDlspeml....klakekaseeglvefvvadaeklpfpdnsfDlvvss 67 +GtG l+ a+a+ ga v+g+D++ +++ k+ +++++ +g+ e ++a++++ +++ + D+ vs sp|Q7Z4G4-2|TRM11_HUMAN 224 VGTGGLLIACAHFGAYVYGTDIDYNTVhglgKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSD 290 699********9***************5555444555544444666899999999999999988875 PP >> sp|Q9BV86-2|NTM1A_HUMAN Isoform 2 of N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens GN=NTMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.5 0.0 0.0017 0.89 1 43 [. 66 109 .. 66 137 .. 0.79 Alignments for each domain: == domain 1 score: 12.5 bits; conditional E-value: 0.0017 EEET-TTSHHHHHHH.HTTSEEEEEES-HHHHHHHHHHCCHHT- CS Methyltransf_11 1 LdvGcGtGrlaeala.krgarvvgvDlspemlklakekaseegl 43 Ld+G+G Gr+++ l +++v vD+++ +l +ak+ eeg sp|Q9BV86-2|NTM1A_HUMAN 66 LDCGAGIGRITKRLLlPLFREVDMVDITEDFLVQAKTYLGEEGK 109 8**************4555*************999998888875 PP >> sp|Q5T8I9|HENMT_HUMAN Small RNA 2'-O-methyltransferase OS=Homo sapiens GN=HENMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.8 0.0 0.0056 2.8 2 74 .. 53 138 .. 52 156 .. 0.74 Alignments for each domain: == domain 1 score: 10.8 bits; conditional E-value: 0.0056 EET-TTSHHHHHHH.HTT.SEEEEEES-HHHHHHH......HHHCCHHT-............EEETTEECCCTSS-TT-EEEEEEES- CS Methyltransf_11 2 dvGcGtGrlaeala.krg.arvvgvDlspemlkla......kekaseegl............vefvvadaeklpfpdnsfDlvvssev 69 d+GcG +l++ l+ + + + +vgvD+++ l++ l +++ ++++ + + + fDl+++ e sp|Q5T8I9|HENMT_HUMAN 53 DLGCGDTSLLRLLKvNPCiELLVGVDINEDKLRWRgdslapF-------LgdflkprdlnltITLYHGSVVERDSRLLGFDLITCIEL 133 9*************666699************6663322230.......134455555577777788888886666668999999999 PP CCC-C CS Methyltransf_11 70 lhhve 74 ++h++ sp|Q5T8I9|HENMT_HUMAN 134 IEHLD 138 99995 PP >> sp|Q7Z4G4|TRM11_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.1 0.0 0.0023 1.2 5 67 .. 224 290 .. 220 307 .. 0.80 Alignments for each domain: == domain 1 score: 12.1 bits; conditional E-value: 0.0023 -TTSHHHHHHHHTTSEEEEEES-HHHH....HHHHHHCCHHT-EEETTEECCCTSS-TT-EEEEEEE CS Methyltransf_11 5 cGtGrlaealakrgarvvgvDlspeml....klakekaseeglvefvvadaeklpfpdnsfDlvvss 67 +GtG l+ a+a+ ga v+g+D++ +++ k+ +++++ +g+ e ++a++++ +++ + D+ vs sp|Q7Z4G4|TRM11_HUMAN 224 VGTGGLLIACAHFGAYVYGTDIDYNTVhglgKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSD 290 699********9***************5555444555544444666899999999999999988875 PP >> tr|J3KMW5|J3KMW5_HUMAN Protein FAM173A OS=Homo sapiens GN=FAM173A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.2 0.0 0.0021 1.1 1 57 [. 80 140 .. 80 144 .. 0.91 Alignments for each domain: == domain 1 score: 12.2 bits; conditional E-value: 0.0021 EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-...EEETTEECCCTSS- CS Methyltransf_11 1 LdvGcGtGrlaealakrg.arvvgvDlspemlklakekaseegl...vefvvadaeklpfp 57 +d+G+G Gr++ a ++ g + vg +l+p +++la+ +a ++g v +++ d+ klp+ tr|J3KMW5|J3KMW5_HUMAN 80 VDLGSGDGRIVLAAHRCGlRPAVGYELNPWLVALARLHAWRAGCagsVCYRRKDLWKLPLL 140 59*************999**********************999999988999999999864 PP >> sp|Q9H867-5|MT21D_HUMAN Isoform 5 of Protein-lysine methyltransferase METTL21D OS=Homo sapiens GN=METTL21D # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.0 0.0026 1.3 1 52 [. 72 120 .. 72 162 .. 0.67 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.0026 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-.....EEETTEECC CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl.....vefvvadae 52 L++G+GtG++ a ga+vv +Dl +e+ +l k++++ +++ v + sp|Q9H867-5|MT21D_HUMAN 72 LELGSGTGAVGLMAATLGADVVVTDL-EELQDLLKMNINMNKHlvtgsV-------Q 120 89***********************8.5566799999999997543321.......2 PP >> tr|H3BTF5|H3BTF5_HUMAN Methyltransferase-like protein 22 OS=Homo sapiens GN=METTL22 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.7 0.0 0.003 1.5 1 43 [. 154 196 .. 154 227 .. 0.86 Alignments for each domain: == domain 1 score: 11.7 bits; conditional E-value: 0.003 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT- CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl 43 L++G+GtG+ + a +++v+++D+ + +l ++++++ + + tr|H3BTF5|H3BTF5_HUMAN 154 LELGAGTGLASIIAATMARTVYCTDVGADLLSMCQRNIALNSH 196 89*************999*****************99987765 PP >> sp|Q9H867|MT21D_HUMAN Protein-lysine methyltransferase METTL21D OS=Homo sapiens GN=METTL21D PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.4 0.0 0.0037 1.9 1 52 [. 72 120 .. 72 162 .. 0.68 Alignments for each domain: == domain 1 score: 11.4 bits; conditional E-value: 0.0037 EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-..EEETTEECC CS Methyltransf_11 1 LdvGcGtGrlaealakrgarvvgvDlspemlklakekaseegl..vefvvadae 52 L++G+GtG++ a ga+vv +Dl +e+ +l k++++ +++ ++++ sp|Q9H867|MT21D_HUMAN 72 LELGSGTGAVGLMAATLGADVVVTDL-EELQDLLKMNINMNKHlvT----GSVQ 120 89***********************8.5566799999999987541....3332 PP >> tr|I7HFW6|I7HFW6_HUMAN Acetylserotonin O-methyltransferase (Fragment) OS=Homo sapiens GN=ASMT PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.0 0.0025 1.3 44 94 .. 9 59 .. 2 60 .. 0.86 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.0025 EEETTEECCCTSS-TT-EEEEEEES-CCC-..CCHHHHHHHHHHHEEEEEEEE CS Methyltransf_11 44 vefvvadaeklpfpdnsfDlvvssevlhhv..edpekalkeiaRvLkpgGllv 94 + +v +d+ k p+p+ Dl ++ vlh + + +++l+ i+ +kpgG ++ tr|I7HFW6|I7HFW6_HUMAN 9 LPCVPGDFFKDPLPE--ADLYILARVLHDWadGKCSHLLERIYHTCKPGGGIL 59 567889999989999..9************765799*************9765 PP >> sp|Q9BV44|THUM3_HUMAN THUMP domain-containing protein 3 OS=Homo sapiens GN=THUMPD3 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.0 0.0 0.0051 2.6 37 89 .. 371 436 .. 324 442 .. 0.65 Alignments for each domain: == domain 1 score: 11.0 bits; conditional E-value: 0.0051 HCCHHT-.........EEETTEECCCTSS-TT-EEEEEEES-CCC-........CCHHHHHHHHHHHEEE CS Methyltransf_11 37 kaseegl.........vefvvadaeklpfpdnsfDlvvssevlhhv........edpekalkeiaRvLkp 89 ++ ++ v+ d+ +lp++ +s+D++v + + ++l+e+ Rv+ p sp|Q9BV44|THUM3_HUMAN 371 QI----KegkpswglpIDAVQWDICNLPLRTGSVDIIVTDLPFGKRmgskkrnwNLYPACLREMSRVCTP 436 22....0223466778889*******************99844433343333336778888888888877 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (95 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 2371 (0.0267991); expected 1769.5 (0.02) Passed bias filter: 2272 (0.0256802); expected 1769.5 (0.02) Passed Vit filter: 329 (0.00371865); expected 88.5 (0.001) Passed Fwd filter: 174 (0.0019667); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 174 [number of targets reported over threshold] # CPU time: 0.53u 0.03s 00:00:00.56 Elapsed: 00:00:00.24 # Mc/sec: 13882.08 // [ok]