# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_12.hmm.txt
# target sequence database: proteomes/Saccharomyces_cerevisiae.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_12 [M=99]
Accession: PF08242.11
Description: Methyltransferase domain
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
7.8e-16 57.1 5.1 5e-15 54.5 0.0 3.3 2 sp|Q08641|AB140_YEAST tRNA(Thr) (cytosine(32)-N(3))-methyltr
1.1e-15 56.7 1.2 3.9e-15 54.9 0.0 2.6 3 sp|Q06668|OMS1_YEAST Methyltransferase OMS1, mitochondrial
8e-14 50.7 0.0 1.4e-13 49.9 0.0 1.4 1 sp|P38892|CRG1_YEAST Probable S-adenosylmethionine-dependen
3.7e-12 45.3 0.1 1.2e-11 43.7 0.0 1.9 1 sp|P25087|ERG6_YEAST Sterol 24-C-methyltransferase OS=Sacch
4.4e-11 41.9 0.0 1.1e-10 40.5 0.0 1.7 1 sp|P27680|COQ3_YEAST Ubiquinone biosynthesis O-methyltransf
9e-10 37.7 0.0 1.6e-09 36.9 0.0 1.4 1 sp|P32643|TMT1_YEAST Trans-aconitate 3-methyltransferase OS
2.3e-09 36.4 0.3 7.3e-09 34.7 0.0 2.0 1 sp|P32783|MCES_YEAST mRNA cap guanine-N7 methyltransferase
3.2e-08 32.7 0.0 5.7e-08 31.9 0.0 1.4 1 sp|P49017|COQ5_YEAST 2-methoxy-6-polyprenyl-1,4-benzoquinol
1.6e-07 30.5 0.1 2.8e-07 29.7 0.1 1.5 1 sp|P40516|EFM4_YEAST Protein-lysine N-methyltransferase EFM
4.3e-07 29.0 0.0 2e-06 27.0 0.0 2.1 1 sp|P25627|BUD23_YEAST 18S rRNA (guanine(1575)-N(7))-methyltr
7e-07 28.4 0.7 1.3e-06 27.5 0.0 1.8 2 sp|P49957|TRM9_YEAST tRNA (carboxymethyluridine(34)-5-O)-me
9.5e-05 21.5 0.0 0.0032 16.7 0.0 2.5 2 sp|P38278|BMT2_YEAST 25S rRNA (adenine(2142)-N(1))-methyltr
0.00013 21.1 0.0 0.00036 19.7 0.0 1.8 1 sp|P38074|HMT1_YEAST Protein arginine N-methyltransferase 1
0.00083 18.5 0.1 0.0024 17.0 0.1 1.8 1 sp|Q12455|SPSY_YEAST Spermine synthase OS=Saccharomyces cer
0.0011 18.1 0.0 0.087 12.0 0.0 2.5 2 sp|P53934|CARME_YEAST Carnosine N-methyltransferase OS=Sacch
0.0016 17.6 0.1 0.012 14.8 0.1 2.1 1 sp|Q03920|MTQ2_YEAST eRF1 methyltransferase catalytic subun
0.0022 17.2 0.0 0.0052 16.0 0.0 1.6 1 sp|P41819|DIM1_YEAST Dimethyladenosine transferase OS=Sacch
0.0048 16.1 0.1 0.021 14.0 0.0 2.0 2 sp|Q12074|SPEE_YEAST Spermidine synthase OS=Saccharomyces c
0.006 15.8 0.0 0.018 14.2 0.0 1.8 1 sp|Q12009|TRMB_YEAST tRNA (guanine-N(7)-)-methyltransferase
------ inclusion threshold ------
0.012 14.9 0.0 0.022 14.0 0.0 1.5 1 sp|P47163|EFM3_YEAST Protein-lysine N-methyltransferase EFM
0.013 14.7 0.0 0.029 13.6 0.0 1.6 1 sp|P38347|EFM2_YEAST Protein-lysine N-methyltransferase EFM
0.023 13.9 0.0 0.046 12.9 0.0 1.4 1 sp|P53944|MTQ1_YEAST Mitochondrial N(5)-glutamine methyltra
0.026 13.7 0.0 0.054 12.7 0.0 1.6 1 sp|P38340|NTM1_YEAST Alpha N-terminal protein methyltransfe
1.2 8.4 5.1 0.87 8.8 0.7 3.0 2 sp|P43565|RIM15_YEAST Serine/threonine-protein kinase RIM15
Domain annotation for each sequence (and alignments):
>> sp|Q08641|AB140_YEAST tRNA(Thr) (cytosine(32)-N(3))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 20450
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 1.4 2.5 0.7 1.8e+02 31 62 .. 216 245 .. 190 305 .. 0.64
2 ! 54.5 0.0 2e-17 5e-15 2 99 .] 439 543 .. 438 543 .. 0.81
Alignments for each domain:
== domain 1 score: 1.4 bits; conditional E-value: 0.7
Methyltransf_12 31 saiedakeklakrennnnnnvnlealdlldld 62
+ ++k+k + ++++n n +++ + d++ +
sp|Q08641|AB140_YEAST 216 NK--KKKNKKKNKKKRNGNVNTNANVDDSTKT 245
22..2333333333333334444444444333 PP
== domain 2 score: 54.5 bits; conditional E-value: 2e-17
Methyltransf_12 2 eiGcGtGsllrallekl..pdieytgvDispsaiedakeklakrenn.nnnnvnlealdlldldgg...ssfDvvvasnvlhhl..kd 81
eiGcG G++ +++l+++ +++++++ D+ p+a+e k+ +++ ++ +++ ++l + d ++l+ g +s+D++v+++v+++l ++
sp|Q08641|AB140_YEAST 439 EIGCGAGNTFFPILKDNenENLRIIAADFAPRAVELVKNSEQFNPKYgHATVWDLANPD-GNLPDGvepHSVDIAVMIFVFSALapNQ 525
9****************999**************6555555555544044444444444.445444588****************999 PP
Methyltransf_12 82 irealdniyklLkpgGrl 99
+++a+dn++k LkpgG++
sp|Q08641|AB140_YEAST 526 WDQAMDNLHKILKPGGKI 543
99**************86 PP
>> sp|Q06668|OMS1_YEAST Methyltransferase OMS1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -2.0 0.0 8.5 2.1e+03 35 62 .. 74 101 .. 60 114 .. 0.77
2 ? -1.9 0.1 7.8 2e+03 44 44 .. 179 179 .. 132 220 .. 0.60
3 ! 54.9 0.0 1.5e-17 3.9e-15 1 99 [] 246 357 .. 246 357 .. 0.93
Alignments for each domain:
== domain 1 score: -2.0 bits; conditional E-value: 8.5
Methyltransf_12 35 dakeklakrennnnnnvnlealdlldld 62
ake++ ++ + n +v++ a+ +++
sp|Q06668|OMS1_YEAST 74 LAKERFEEQLRSPNRFVRWGAIARSEKF 101
4788888888888888888887776655 PP
== domain 2 score: -1.9 bits; conditional E-value: 7.8
Methyltransf_12 44 e 44
+
sp|Q06668|OMS1_YEAST 179 G 179
1 PP
== domain 3 score: 54.9 bits; conditional E-value: 1.5e-17
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsai..edakeklakrennnnnnvnlealdlldldgg............ssfDvvv.asn 74
Le+ cGtG+++++l ++ + ++t++D s++++ +++k + ++ + +++++v +a++l dl+++ ++D++v a++
sp|Q06668|OMS1_YEAST 246 LEVSCGTGRNIKYLDMS-RINSITFLDSSENMMeiTHKKFREKFPKYKKVAFVVGKAENLVDLAEKgkpslenekenqVKYDTIVeAFG 333
8****************.667788*********988899999999999***************999*******************4558 PP
Methyltransf_12 75 vlhhlkdirealdniyklLkpgGrl 99
+++h +d+ +al+n+ klLkp+Gr+
sp|Q06668|OMS1_YEAST 334 LCSH-EDPVKALNNFGKLLKPDGRI 357
8888.******************86 PP
>> sp|P38892|CRG1_YEAST Probable S-adenosylmethionine-dependent methyltransferase CRG1 OS=Saccharomyces cerevisiae (str
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 49.9 0.0 5.6e-16 1.4e-13 1 98 [. 43 137 .. 43 138 .. 0.88
Alignments for each domain:
== domain 1 score: 49.9 bits; conditional E-value: 5.6e-16
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldggssfDvvvasnvlhhlkdirealdni 89
++iGcGtG +++++++ e++g+D+s++++ a++++++r+ ++ ++ + ++l++ ++s+D+v++++++h++ +++++++++
sp|P38892|CRG1_YEAST 43 VDIGCGTGKATFVVEPY--FKEVIGIDPSSAMLSIAEKETNERRLDKKIRFINAPGEDLSSIRPESVDMVISAEAIHWC-NLERLFQQV 128
69***************..**************99999999998877655555555555555558*************8.********* PP
Methyltransf_12 90 yklLkpgGr 98
+ L+ +G
sp|P38892|CRG1_YEAST 129 SSILRSDGT 137
******997 PP
>> sp|P25087|ERG6_YEAST Sterol 24-C-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=55929
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 43.7 0.0 4.7e-14 1.2e-11 1 99 [] 124 220 .. 124 220 .. 0.92
Alignments for each domain:
== domain 1 score: 43.7 bits; conditional E-value: 4.7e-14
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldgg.ssfDvvvasnvlhhlkdirealdn 88
L++GcG+G +r++++ +++++g+ + +i ak+k +++ n +++++ + d + d + ++fD v+a+++ +h ++++ + ++
sp|P25087|ERG6_YEAST 124 LDVGCGVGGPAREIARF-TGCNVIGLNNNDYQI--AKAKYYAKKYNLSDQMDFVKGDFMKMDFEeNTFDKVYAIEATCHAPKLEGVYSE 209
8*************877.***************..66666666667789**********999999************************ PP
Methyltransf_12 89 iyklLkpgGrl 99
iyk+LkpgG +
sp|P25087|ERG6_YEAST 210 IYKVLKPGGTF 220
*********75 PP
>> sp|P27680|COQ3_YEAST Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 40.5 0.0 4.5e-13 1.1e-10 1 96 [. 127 219 .. 127 223 .. 0.88
Alignments for each domain:
== domain 1 score: 40.5 bits; conditional E-value: 4.5e-13
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldggssfDvvvasnvlhhlkdirealdni 89
L++GcG G l++ l++ ++ g+D+ ++ i ake+ +k ++ ++n+e+ l+d g +fD++++ + l+h++ + e+l+++
sp|P27680|COQ3_YEAST 127 LDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKK-DPMLEGKINYECKALEDVTG--QFDIITCMEMLEHVDMPSEILRHC 212
8**************998888888*********666666555.55677999999999988887..9*********************** PP
Methyltransf_12 90 yklLkpg 96
+ L+p+
sp|P27680|COQ3_YEAST 213 WSRLNPE 219
****994 PP
>> sp|P32643|TMT1_YEAST Trans-aconitate 3-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 36.9 0.0 6.2e-12 1.6e-09 1 98 [. 41 144 .. 41 145 .. 0.89
Alignments for each domain:
== domain 1 score: 36.9 bits; conditional E-value: 6.2e-12
Methyltransf_12 1 LeiGcGtGsllrallekl.pdieytgvDispsaiedakeklakrennnnnnvnlealdlldldgg........ssfDvvvasnvlhhlk 80
+++GcG G+ + ++++l p +++g+D+s+ +i +++e +++ +++ +nv ++ + +d + ++ D+++a ++ h++
sp|P32643|TMT1_YEAST 41 VDVGCGPGTATLQMAQELkPFEQIIGSDLSATMI-KTAEVIKEGSPDTYKNVSFKISSSDDFK-FlgadsvdkQKIDMITAVECAHWF- 126
69***************98889999*********.9999999999999999999987754443.3699*******************6. PP
Methyltransf_12 81 direaldniyklLkpgGr 98
d +++ +++y+ L+++G
sp|P32643|TMT1_YEAST 127 DFEKFQRSAYANLRKDGT 144
9************99997 PP
>> sp|P32783|MCES_YEAST mRNA cap guanine-N7 methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 34.7 0.0 2.9e-11 7.3e-09 1 99 [] 169 279 .. 169 279 .. 0.87
Alignments for each domain:
== domain 1 score: 34.7 bits; conditional E-value: 2.9e-11
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldgg..........ssfDvvvasnvlhhl 79
Le+GcG G lr+ ++ ++++g+Dis ++i+ a ++ ++ +n + + v + d + + g D+v ++lh+
sp|P32783|MCES_YEAST 169 LELGCGKGGDLRKYGAA-GISQFIGIDISNASIQEAHKRYRSMRNLDYQVVLIT-GDCFGESLGvavepfpdcrFPCDIVSTQFCLHYA 255
8****************.888999*********999999999998775555555.5544444447*******999************** PP
Methyltransf_12 80 ....kdirealdniyklLkpgGrl 99
++ r+al n++k Lk gG++
sp|P32783|MCES_YEAST 256 feteEKARRALLNVAKSLKIGGHF 279
***99999**************86 PP
>> sp|P49017|COQ5_YEAST 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Saccharomyces cerevisiae (st
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 31.9 0.0 2.3e-10 5.7e-08 2 99 .] 117 223 .. 116 223 .. 0.84
Alignments for each domain:
== domain 1 score: 31.9 bits; conditional E-value: 2.3e-10
Methyltransf_12 2 eiGcGtGsllrallekl......pdieytgvDispsaiedakeklakre.nnnnnnvnlealdlldldgg..ssfDvvvasnvlhhlkd 81
++ +G+G++++ ll++ +++ vDi+p++++ +++ +++ + +v++ + + ++l++ +s D+ ++s+ + ++ d
sp|P49017|COQ5_YEAST 117 DVAGGSGDIAFGLLDHAeskfgdTESTMDIVDINPDMLKEGEKRAMEQGkYFKDPRVRFLVSNGEKLEEIdsDSKDIYTVSFGIRNFTD 205
899*************9999966666666*********66666555555055667899999998777777999**************** PP
Methyltransf_12 82 irealdniyklLkpgGrl 99
i++ l+ +y++LkpgG++
sp|P49017|COQ5_YEAST 206 IQKGLNTAYRVLKPGGIF 223
****************85 PP
>> sp|P40516|EFM4_YEAST Protein-lysine N-methyltransferase EFM4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 29.7 0.1 1.1e-09 2.8e-07 1 98 [. 98 205 .. 98 206 .. 0.80
Alignments for each domain:
== domain 1 score: 29.7 bits; conditional E-value: 1.1e-09
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldgg.ssfDvvvasnvlhhl......... 79
+++G+G+G++l++l + + +++g+D+s++++ + + +a+ + n++ +++ d+++ d + +++D+v+ ++l ++
sp|P40516|EFM4_YEAST 98 VDLGTGNGHMLFELHQTEFQGKLVGIDYSEESV-KLASNIAEATG-VDNFISFQQADIFSGDWKpGKYDIVLDKGTLDAIslsgmking 184
59***************99**************.66666666554.668999*****99999999************999888877777 PP
Methyltransf_12 80 .kdireald.niyklLkpgGr 98
d+ ++ + + + Lk++G+
sp|P40516|EFM4_YEAST 185 kLDVVDVYAgVVERILKKDGI 205
744444444144477777775 PP
>> sp|P25627|BUD23_YEAST 18S rRNA (guanine(1575)-N(7))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 20450
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 27.0 0.0 7.8e-09 2e-06 1 99 [] 52 154 .. 52 154 .. 0.71
Alignments for each domain:
== domain 1 score: 27.0 bits; conditional E-value: 7.8e-09
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldggssfDvvvasnvlhhl......... 79
L+iGcG+G + l ++ d +g+Disps+++ + + + + + ++ +sfD++++++++++l
sp|P25627|BUD23_YEAST 52 LDIGCGSGLSGEILTQE-GDHVWCGLDISPSMLATGLSRELEGDL---MLQDMGTGI-PFRA--GSFDAAISISAIQWLcnadtsynd 132
8******9777777666.666666*********333333333333...222222222.2222..4*********************87 PP
Methyltransf_12 80 ..kdirealdniyklLkpgGrl 99
+ + ++++ +y++Lk+gG++
sp|P25627|BUD23_YEAST 133 pkQRLMRFFNTLYAALKKGGKF 154
6444447888**********86 PP
>> sp|P49957|TRM9_YEAST tRNA (carboxymethyluridine(34)-5-O)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 27.5 0.0 5.3e-09 1.3e-06 2 98 .. 51 139 .. 50 140 .. 0.85
2 ? -2.2 0.2 9.4 2.4e+03 46 60 .. 218 232 .. 204 245 .. 0.48
Alignments for each domain:
== domain 1 score: 27.5 bits; conditional E-value: 5.3e-09
Methyltransf_12 2 eiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldggssfDvvvasnvlhhl...kdireald 87
++GcG+G +l + +pdi ++g+D s ie a+ +++ ++ +nl + + +fD ++++ v+hh+ + + e+++
sp|P49957|TRM9_YEAST 51 DVGCGNGKYLGV----NPDIYIIGSDRSDGLIECARGINPSYNLLVADGLNLPHKNE-------TFDFAISIAVVHHWstrERRVEVIR 128
9******65544....489*************8888888888888888888888884.......9*************9966666**** PP
Methyltransf_12 88 niyklLkpgGr 98
++ + L++gG+
sp|P49957|TRM9_YEAST 129 HVLSKLRQGGQ 139
********997 PP
== domain 2 score: -2.2 bits; conditional E-value: 9.4
Methyltransf_12 46 nnnnnvnlealdlld 60
++ + ++ +++++ +
sp|P49957|TRM9_YEAST 218 KSLDDNDEKQQQDQE 232
333333333333322 PP
>> sp|P38278|BMT2_YEAST 25S rRNA (adenine(2142)-N(1))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 2.2 0.0 0.41 1e+02 59 98 .. 107 148 .. 75 149 .. 0.67
2 ! 16.7 0.0 1.3e-05 0.0032 62 98 .. 205 260 .. 177 261 .. 0.77
Alignments for each domain:
== domain 1 score: 2.2 bits; conditional E-value: 0.41
Methyltransf_12 59 ldldggssfDvvvasnvlhhl.kdireald.niyklLkpgGr 98
+++++++ D++v+ +l ++ ++i+++ + y+ +++G+
sp|P38278|BMT2_YEAST 107 NESKSKDTSDLAVMYTLLGYImNQINKLGGlETYQIASQNGQ 148
233333899***********9777775544466777777776 PP
== domain 2 score: 16.7 bits; conditional E-value: 1.3e-05
Methyltransf_12 62 dgg................ssfDvvvasnvlhhl...kdirealdniyklLkpgGr 98
++g ++fD++ +s vl+ + +d+ ++ +++ k Lkp G
sp|P38278|BMT2_YEAST 205 HEGvikqdfmerplprnenDKFDLISCSLVLNFVknhRDRGAMCHRMVKFLKPQGY 260
33346666677777788889**************9999999*************97 PP
>> sp|P38074|HMT1_YEAST Protein arginine N-methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 19.7 0.0 1.4e-06 0.00036 1 97 [. 63 159 .. 63 161 .. 0.63
Alignments for each domain:
== domain 1 score: 19.7 bits; conditional E-value: 1.4e-06
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsai.edakeklakrennnnnnvnlealdlldldggssfDvvv...asnvlhhlkdirea 85
L++GcGtG l++ +++ +++gvD s+ ++ +l+ + ++ + ++ + +d++ ++D+++ + +l + ++ +
sp|P38074|HMT1_YEAST 63 LDVGCGTGILSMFAAKH-GAKHVIGVDMSSIIEmAKELVELNGFS-DKITLLRGKLEDVHLPF--PKVDIIIsewMGYFLLYESMMDTV 147
8*******999999999.889999****98655223333333333.24444444444444333..488988855555666665666666 PP
Methyltransf_12 86 ldniyklLkpgG 97
l + L+ gG
sp|P38074|HMT1_YEAST 148 LYARDHYLVEGG 159
666666666666 PP
>> sp|Q12455|SPSY_YEAST Spermine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=SPE4 PE
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.0 0.1 9.6e-06 0.0024 1 71 [. 93 172 .. 93 176 .. 0.78
Alignments for each domain:
== domain 1 score: 17.0 bits; conditional E-value: 9.6e-06
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldgg............ssfDvvv 71
L iG+G+G +lr+++++ ++t v+i++s+ie ++ l +n ++ + ldl dg ++fDv++
sp|Q12455|SPSY_YEAST 93 LIIGGGDGGVLREVAKHSCVEDITMVEIDSSVIELSRKFLPTLSNGAFDDER---LDLKLCDGFkflqdigasdvhKKFDVII 172
569**************999999**********7777777777765554444...4444444445688999****9****998 PP
>> sp|P53934|CARME_YEAST Carnosine N-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=5592
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 3.5 0.0 0.15 39 4 30 .. 146 177 .. 143 211 .. 0.74
2 ! 12.0 0.0 0.00035 0.087 64 98 .. 265 299 .. 239 300 .. 0.82
Alignments for each domain:
== domain 1 score: 3.5 bits; conditional E-value: 0.15
Methyltransf_12 4 GcGtGsllrallekl.....pdieytgvDisp 30
GcGtG+ll l + + +y+ + +s+
sp|P53934|CARME_YEAST 146 GCGTGRLLVDLSRMGyncegNEFSYHMLLVSQ 177
9*******999888545544444455444444 PP
== domain 2 score: 12.0 bits; conditional E-value: 0.00035
Methyltransf_12 64 gssfDvvvasnvlhhlkdirealdniyklLkpgGr 98
++s Dvvv ++++ +i ++ld i ++LkpgG+
sp|P53934|CARME_YEAST 265 ENSKDVVVTNFFIDTGSNILDYLDTIGHVLKPGGI 299
2699******************************6 PP
>> sp|Q03920|MTQ2_YEAST eRF1 methyltransferase catalytic subunit MTQ2 OS=Saccharomyces cerevisiae (strain ATCC 204508 /
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.8 0.1 4.8e-05 0.012 2 72 .. 48 121 .. 47 176 .. 0.80
Alignments for each domain:
== domain 1 score: 14.8 bits; conditional E-value: 4.8e-05
Methyltransf_12 2 eiGcGtGsllrallekl...pdieyt.gvDispsaiedakeklakrennnnnnvnlealdlldldggssfDvvva 72
eiG+G+G ++ l ++ ++ +++ +vDi+p a+ a + +ak + + +++++ + dl ++ ++++Dv +
sp|Q03920|MTQ2_YEAST 48 EIGSGSGIVTTFLMQNKiipQENSIHlAVDINPWAL-EATLDTAKLNSCKSSFLEVIQADLNSSIRNNQVDVLIF 121
9******99988877778997777777*********.9999999999999*********9988888877777654 PP
>> sp|P41819|DIM1_YEAST Dimethyladenosine transferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=55929
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 16.0 0.0 2.1e-05 0.0052 1 69 [. 61 124 .. 61 135 .. 0.74
Alignments for each domain:
== domain 1 score: 16.0 bits; conditional E-value: 2.1e-05
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldggssfDv 69
Le+G GtG+l+ ++le+ ++++v+ +p++ + ++ + +++++ d +++ + +fD+
sp|P41819|DIM1_YEAST 61 LEVGPGTGNLTVRILEQ--AKNVVAVEMDPRMAAELTKRVRGTPV--EKKLEIMLGDFMKTELP-YFDI 124
8****************..**************665555555443..34444444455555444.6665 PP
>> sp|Q12074|SPEE_YEAST Spermidine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=SPE3
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -0.8 0.0 3.4 8.6e+02 66 94 .. 53 82 .. 18 86 .. 0.65
2 ! 14.0 0.0 8.3e-05 0.021 1 71 [. 93 166 .. 93 170 .. 0.69
Alignments for each domain:
== domain 1 score: -0.8 bits; conditional E-value: 3.4
Methyltransf_12 66 sfDvvvas.nvlhhlkdirealdniyklLk 94
++ v+++ nv+++++ ++a +++ ++L+
sp|Q12074|SPEE_YEAST 53 TYGNVLVLdNVIQATERDEFAYQEMIAHLA 82
333344444999999888888888877776 PP
== domain 2 score: 14.0 bits; conditional E-value: 8.3e-05
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldgg.....ssfDvvv 71
L iG+G+G +lr++ ++ + e +Di++++i ke l + + + ++ ++++ +d + ++fDv++
sp|Q12074|SPEE_YEAST 93 LVIGGGDGGVLREVVKHDSVEEAWLCDIDEAVIRLSKEYLPEMAA-SYSHPKVKTHI-GDGFQFlrdyqNTFDVII 166
569**************99999***********666666655443.33333333222.222222446778888887 PP
>> sp|Q12009|TRMB_YEAST tRNA (guanine-N(7)-)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.2 0.0 7.2e-05 0.018 2 59 .. 101 158 .. 100 177 .. 0.94
Alignments for each domain:
== domain 1 score: 14.2 bits; conditional E-value: 7.2e-05
Methyltransf_12 2 eiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdll 59
+iGcG G l+ l +++p+ ++g++i ++ + + ++ + +nn +++ ++++++l
sp|Q12009|TRMB_YEAST 101 DIGCGFGGLMIDLSPAFPEDLILGMEIRVQVTNYVEDRIIALRNNTASKHGFQNINVL 158
8********************************************9999999999976 PP
>> sp|P47163|EFM3_YEAST Protein-lysine N-methyltransferase EFM3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 14.0 0.0 8.6e-05 0.022 1 75 [. 171 250 .. 171 268 .. 0.70
Alignments for each domain:
== domain 1 score: 14.0 bits; conditional E-value: 8.6e-05
Methyltransf_12 1 LeiGcGtGsllrallekl..pdieytgvDispsaiedakeklakrennnnnnvnlealdlldldgg.........ssfDvvvasnv 75
Le+G+GtG ++ ++l+k + +++D +++ + +++k +++ nn+v+ ++ d+ +l+ + + D+vv ++v
sp|P47163|EFM3_YEAST 171 LEVGAGTGIVSLVILQKYheFVNKMYVTDGDSNLV-ETQLKRNFEL---NNEVRENEPDI-KLQ-RlwwgsdrvpEDIDLVVGADV 250
8****************9633567789********.3333333333...33333333332.222.124558888888888887666 PP
>> sp|P38347|EFM2_YEAST Protein-lysine N-methyltransferase EFM2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.6 0.0 0.00012 0.029 1 98 [. 258 365 .. 258 366 .. 0.77
Alignments for each domain:
== domain 1 score: 13.6 bits; conditional E-value: 0.00012
Methyltransf_12 1 LeiGcGtGsllrallekl......pdieytgvDispsaiedakeklakrennnnnnvnlealdlldldgg.......ssfDvvvasnvl 76
Le+G+GtG + ++ k ++ie+ ++D+ + + + k+ + ++ ++v+ e ld + + + fDv+++++ +
sp|P38347|EFM2_YEAST 258 LELGAGTGLVGLSWALKWkelygtENIEIFVTDLPEIVT-NLKKNVSLNNLG--DFVQAEILDWTNPHDFidkfgheNEFDVILIADPI 343
8********999999888889999999999999999888.444444444443..4444444444444444667779************9 PP
Methyltransf_12 77 hhlkdirealdniyklLkpgGr 98
++++ +++ i k L+ G
sp|P38347|EFM2_YEAST 344 YSPQHPEWVVNMISKFLAASGT 365
9999999999999999998875 PP
>> sp|P53944|MTQ1_YEAST Mitochondrial N(5)-glutamine methyltransferase MTQ1 OS=Saccharomyces cerevisiae (strain ATCC 20
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.9 0.0 0.00018 0.046 6 68 .. 120 183 .. 117 188 .. 0.76
Alignments for each domain:
== domain 1 score: 12.9 bits; conditional E-value: 0.00018
Methyltransf_12 6 GtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldgg.ssfD 68
GtG ++ al + ++++t++D+s++ai+ ke + k++ + v+ + l+ +d+ s+ D
sp|P53944|MTQ1_YEAST 120 GTGCIALALSHGIANCTFTAIDVSTRAIKLVKENMLKNKVSGGKLVQHNILSSKASDEYpSHID 183
89999999999999**************999999988887666666666555444444355555 PP
>> sp|P38340|NTM1_YEAST Alpha N-terminal protein methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 /
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.7 0.0 0.00021 0.054 1 98 [. 68 166 .. 68 167 .. 0.74
Alignments for each domain:
== domain 1 score: 12.7 bits; conditional E-value: 0.00021
Methyltransf_12 1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrenn.nnnnvnlealdlldldggssfDvvvasnvlhhl..kdireal 86
++iG+G G++++ +l k + +++ v++ + +ie+ +la+ +++ + ++ ++ d +++ ++++ ++ hl +++ ++l
sp|P38340|NTM1_YEAST 68 VDIGAGIGRVSKTMLHK-HAAKIDLVEPVKPFIEQMHVELAELKDKgQIGQIYEVGMQDWTPDA-GKYWLIWCQWCVGHLpdAELVAFL 154
69***************.9**************6666555555543123344444444444444.489999999888888677777999 PP
Methyltransf_12 87 dniyklLkpgGr 98
+++ L p+G
sp|P38340|NTM1_YEAST 155 KRCIVGLQPNGT 166
999999999996 PP
>> sp|P43565|RIM15_YEAST Serine/threonine-protein kinase RIM15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 8.8 0.7 0.0034 0.87 21 89 .. 316 390 .. 300 394 .. 0.55
2 ? -1.1 0.0 4.4 1.1e+03 17 74 .. 1059 1115 .. 1051 1117 .. 0.78
Alignments for each domain:
== domain 1 score: 8.8 bits; conditional E-value: 0.0034
Methyltransf_12 21 ieytgvDispsai....edakekla...krennnnnnvnlealdlldldggssfDvvvasnvlhhlkdirealdni 89
+ ++Di+ps + + + ++nnnnnn+n++++ lld+ + + D+v +++ ++ + ++ ++n+
sp|P43565|RIM15_YEAST 316 LCQDAIDINPSEMvpdlYHSLSTFPqdnGNNNNNNNNNNNNNNALLDQFPI-QKDTVSLNSYFQFSPRTNHNIQNV 390
555566666666664442222233300033444444444444445555554.899999999988876666666555 PP
== domain 2 score: -1.1 bits; conditional E-value: 4.4
Methyltransf_12 17 klpdieytgvDispsaiedakeklakrennnnnnvnlealdlldldggssfDvvvasn 74
+ +++++ +Dis+s+ + ++ ++++ nn + l +++ +++d s D++ a n
sp|P43565|RIM15_YEAST 1059 SESQLSFSLLDISRSSTPPLANPTNSNANNIMRRKSLTENKSFSNDLL-SSDAIAATN 1115
446889999*******99999999998888888888888888777776.778777765 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (99 nodes)
Target sequences: 6049 (2936363 residues searched)
Passed MSV filter: 369 (0.0610018); expected 121.0 (0.02)
Passed bias filter: 333 (0.0550504); expected 121.0 (0.02)
Passed Vit filter: 55 (0.00909241); expected 6.0 (0.001)
Passed Fwd filter: 24 (0.0039676); expected 0.1 (1e-05)
Initial search space (Z): 6049 [actual number of targets]
Domain search space (domZ): 24 [number of targets reported over threshold]
# CPU time: 0.08u 0.00s 00:00:00.08 Elapsed: 00:00:00.03
# Mc/sec: 9690.00
//
[ok]