# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_15.hmm.txt
# target sequence database: proteomes/Danio_rerio.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_15 [M=165]
Accession: PF09445.9
Description: RNA cap guanine-N2 methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
4.2e-42 144.2 0.0 6.7e-42 143.5 0.0 1.3 1 tr|A0A286YB74|A0A286YB74_DANRE LYN proto-oncogene, Src family t
2.9e-05 24.3 0.3 9.9e-05 22.6 0.0 2.1 3 tr|A0A2R8Q256|A0A2R8Q256_DANRE tRNA methyltransferase 2 homolog
0.00011 22.5 0.0 0.00025 21.3 0.0 1.7 1 sp|B8A5G9|TRM5_DANRE tRNA (guanine(37)-N1)-methyltran
0.0044 17.2 0.0 0.0082 16.4 0.0 1.5 1 sp|Q0P466|TYW2_DANRE tRNA wybutosine-synthesizing pro
------ inclusion threshold ------
0.014 15.6 0.0 0.022 15.0 0.0 1.2 1 tr|A0A1D5NT05|A0A1D5NT05_DANRE Methyltransferase-like 15 OS=Dan
0.023 14.9 0.0 0.036 14.3 0.0 1.3 1 tr|A0A0R4IAT4|A0A0R4IAT4_DANRE NOL1/NOP2/Sun domain family, mem
0.049 13.8 0.0 0.095 12.9 0.0 1.5 1 sp|A4QP75|TRM2B_DANRE tRNA (uracil(54)-C(5))-methyltra
0.093 12.9 0.2 0.17 12.1 0.2 1.7 1 tr|B3DIQ7|B3DIQ7_DANRE Methyltransferase-like 22 OS=Dan
0.13 12.5 0.3 0.32 11.2 0.3 1.7 1 sp|Q5U9X3|GPC6A_DANRE G-protein coupled receptor famil
0.13 12.4 0.0 0.37 11.0 0.0 1.7 2 tr|B0S688|B0S688_DANRE rRNA adenine N(6)-methyltransfer
0.17 12.1 0.0 0.28 11.4 0.0 1.3 1 tr|X1WET5|X1WET5_DANRE THUMP domain-containing 2 OS=Dan
0.17 12.1 0.0 0.28 11.4 0.0 1.3 1 tr|A0A2R8RIC7|A0A2R8RIC7_DANRE Uncharacterized protein OS=Danio
0.2 11.9 0.0 0.37 11.0 0.0 1.4 1 tr|F1QJH5|F1QJH5_DANRE HemK methyltransferase family me
0.21 11.8 0.0 0.31 11.2 0.0 1.2 1 tr|A0A2R8Q1A0|A0A2R8Q1A0_DANRE Uncharacterized protein OS=Danio
0.24 11.6 0.0 0.44 10.7 0.0 1.4 1 tr|Q504A2|Q504A2_DANRE Zgc:109986 OS=Danio rerio OX=795
Domain annotation for each sequence (and alignments):
>> tr|A0A286YB74|A0A286YB74_DANRE LYN proto-oncogene, Src family tyrosine kinase OS=Danio rerio OX=7955 GN=lyn PE=1 SV=
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 143.5 0.0 3.9e-45 6.7e-42 2 164 .. 645 797 .. 644 798 .. 0.94
Alignments for each domain:
== domain 1 score: 143.5 bits; conditional E-value: 3.9e-45
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpP 80
e+++D+f+G GGn+iqfa++ ++vi+idi++ rl+laqhNa vYgv++++++ +gd+ +l +l+ d+vflSpP
tr|A0A286YB74|A0A286YB74_DANRE 645 ELIIDAFCGVGGNAIQFALTGKRVIGIDIDPVRLALAQHNAAVYGVEQRIDFLQGDFLQLAPHLRG-----DMVFLSPP 718
679*********************************************************999764.....789***** PP
Methyltransf_15 81 wGGpsYkkkekfdlekkleplklekllkesvklskniilfLPrnsdlkqlaaltaevlenaskvkvvklkenglvkall 159
wGGp+Y ++f++++ + p + ++++ s +s+ni+ fLPrn+d++q+a+l +++ kv+v + n+ +k+++
tr|A0A286YB74|A0A286YB74_DANRE 719 WGGPEYLTADVFNIQTMMTPDGF-EIFRLSKMISDNIVYFLPRNADMEQIASL----AGPGGKVEVEQNFLNNKLKTIT 792
**************777777665.6999**********************998....8********************* PP
Methyltransf_15 160 aylge 164
ay+g+
tr|A0A286YB74|A0A286YB74_DANRE 793 AYFGN 797
***96 PP
>> tr|A0A2R8Q256|A0A2R8Q256_DANRE tRNA methyltransferase 2 homolog A OS=Danio rerio OX=7955 GN=trmt2a PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.1 0.0 4.8 8.2e+03 119 146 .. 81 117 .. 63 134 .. 0.66
2 ? -2.3 0.0 2.7 4.6e+03 110 136 .. 346 372 .. 328 379 .. 0.68
3 ! 22.6 0.0 5.8e-08 9.9e-05 3 70 .. 459 525 .. 457 561 .. 0.82
Alignments for each domain:
== domain 1 score: -3.1 bits; conditional E-value: 4.8
Methyltransf_15 119 lfLPrnsdlkqlaaltaevlenaskvk.........v 146
LP+ ++l++++++ +n +k+k v
tr|A0A2R8Q256|A0A2R8Q256_DANRE 81 QNLPKYIGFNDLKKFLNKHGINPHKIKllgrqkfafV 117
4578888888888887777777777774444444443 PP
== domain 2 score: -2.3 bits; conditional E-value: 2.7
Methyltransf_15 110 svklskniilfLPrnsdlkqlaaltae 136
+k + +++f P++ + k+l++l ++
tr|A0A2R8Q256|A0A2R8Q256_DANRE 346 RLKQTMAMVFFNPQKLQEKELEELKQN 372
344455566788887777777777655 PP
== domain 3 score: 22.6 bits; conditional E-value: 5.8e-08
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei 70
+vlD+++G+G i +a+ +kvi+i+ ++ +k a+ Na++ g +v++ +g+ ++++ ++ + +
tr|A0A2R8Q256|A0A2R8Q256_DANRE 459 TVLDVCCGTGTIGISLAKRVKKVIGIELCQEAVKDAEANAKANG-LTNVEFHCGKAEDVFPTILNAVV 525
69****************************************96.57899999998885554444444 PP
>> sp|B8A5G9|TRM5_DANRE tRNA (guanine(37)-N1)-methyltransferase OS=Danio rerio OX=7955 GN=trmt5 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 21.3 0.0 1.5e-07 0.00025 3 60 .. 285 342 .. 283 456 .. 0.91
Alignments for each domain:
== domain 1 score: 21.3 bits; conditional E-value: 1.5e-07
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe 60
+v+D+f+G G +i a+ + v a d n++ + qhNa++ v++k+t+ d +
sp|B8A5G9|TRM5_DANRE 285 TVVDVFAGVGPFAIPAARRGCAVLANDLNPESFRWLQHNAKLNKVDQKITTSNLDGRD 342
689**********************************************987666555 PP
>> sp|Q0P466|TYW2_DANRE tRNA wybutosine-synthesizing protein 2 homolog OS=Danio rerio OX=7955 GN=trmt12 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 16.4 0.0 4.8e-06 0.0082 3 61 .. 220 280 .. 218 323 .. 0.82
Alignments for each domain:
== domain 1 score: 16.4 bits; conditional E-value: 4.8e-06
Methyltransf_15 3 vvlDlfgGaGGnviqfanv..fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfel 61
+v+Dl++G G + + +v+a++ n++ ++ q+N e+ gvs++ t+ +gd +l
sp|Q0P466|TYW2_DANRE 220 TVVDLYAGIGYFTLPYLVHanAAHVHACEWNPDAVAALQRNLEINGVSNRCTVHQGDNRQL 280
688999999988766533323568*********************************8874 PP
>> tr|A0A1D5NT05|A0A1D5NT05_DANRE Methyltransferase-like 15 OS=Danio rerio OX=7955 GN=mettl15 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 15.0 0.0 1.3e-05 0.022 2 61 .. 85 144 .. 84 176 .. 0.89
Alignments for each domain:
== domain 1 score: 15.0 bits; conditional E-value: 1.3e-05
Methyltransf_15 2 evvlDlfgGaGGnviqfanv..fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfel 61
++vlDl GaGG + ++ ++ +v+a d +++ ++aq+ ae Y + kv+ vlg + el
tr|A0A1D5NT05|A0A1D5NT05_DANRE 85 QIVLDLTFGAGGHSKAILQSvpGVTVVAADRDPTAFRMAQQLAEEY--QGKVKPVLGRFSEL 144
689***********9998886767899*******************..9********99885 PP
>> tr|A0A0R4IAT4|A0A0R4IAT4_DANRE NOL1/NOP2/Sun domain family, member 6 OS=Danio rerio OX=7955 GN=nsun6 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 14.3 0.0 2.1e-05 0.036 3 92 .. 235 335 .. 233 361 .. 0.71
Alignments for each domain:
== domain 1 score: 14.3 bits; conditional E-value: 2.1e-05
Methyltransf_15 3 vvlDlfgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe.........llaklklee 69
vlD+++ GG++ ++a v+a+++ +s+++ + +Na++ d ++ +++ + ++ + e
tr|A0A0R4IAT4|A0A0R4IAT4_DANRE 235 RVLDMCAAPGGKTTHIASLmgnQGVVVALEKVRSKMEKILRNAQML-KLDCIKAYCCNSIHavssdpaqeYTEGPPFPE 312
79**************9986553469*******************9.67889999998888444444444333333344 PP
Methyltransf_15 70 ikvdlvflSpPwGGpsYkkkekf 92
++d ++l P G + + ++
tr|A0A0R4IAT4|A0A0R4IAT4_DANRE 313 ESFDRILLDAPCSGLGQRPNMSY 335
45566666666666665555555 PP
>> sp|A4QP75|TRM2B_DANRE tRNA (uracil(54)-C(5))-methyltransferase homolog-B OS=Danio rerio OX=7955 GN=trmt2b PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.9 0.0 5.5e-05 0.095 3 46 .. 323 366 .. 321 432 .. 0.78
Alignments for each domain:
== domain 1 score: 12.9 bits; conditional E-value: 5.5e-05
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYg 46
++lD+++G+G i + + e+vi+i+ ++ ++ a+ Na +
sp|A4QP75|TRM2B_DANRE 323 TLLDVCCGTGAIGISLSPQMERVIGIELIEQAVEDAKFNAALNR 366
68*****************************9999999998764 PP
>> tr|B3DIQ7|B3DIQ7_DANRE Methyltransferase-like 22 OS=Danio rerio OX=7955 GN=mettl22 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.1 0.2 9.8e-05 0.17 3 44 .. 160 201 .. 158 354 .. 0.88
Alignments for each domain:
== domain 1 score: 12.1 bits; conditional E-value: 9.8e-05
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaev 44
+vl l +G+G +i +a+v ++v++ d+ ++ l+++q+N v
tr|B3DIQ7|B3DIQ7_DANRE 160 TVLELGAGTGLTSIVMAMVAKTVYCTDVGEDLLNMCQRNVTV 201
5789999********************************987 PP
>> sp|Q5U9X3|GPC6A_DANRE G-protein coupled receptor family C group 6 member A OS=Danio rerio OX=7955 GN=gprc6a PE=1 SV=
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.2 0.3 0.00019 0.32 36 148 .. 286 403 .. 262 419 .. 0.67
Alignments for each domain:
== domain 1 score: 11.2 bits; conditional E-value: 0.00019
Methyltransf_15 36 klaqhNaevYgvsdkvtlvlgdvfellaklkleei......kvdlvflSpPwGG.psYkkkekfdlekkleplklekllkesvklskn 116
+l + + ++s+++ +v d ++ +++ + + f S +Y k+ +f+ e ++++ l++ lk + +n
sp|Q5U9X3|GPC6A_DANRE 286 QLLFKGLQSRNISNNMVWVASDNWSTAKHILNDGSitdigkVLGFTFKSGNFTSfHQYLKNLQFESEDEMNNSFLKEFLKLNAGNASN 373
555555556666666666666655544444333321211212233344443332248******************************* PP
Methyltransf_15 117 iilfLPrnsdlkqlaaltaevlenaskvkvvk 148
+l L ++++l+++ ++ + v+ a+ +v k
sp|Q5U9X3|GPC6A_DANRE 374 TVLELMKSTNLDKIFSIEMAVTAVAN--AVAK 403
**************999777766655..3334 PP
>> tr|B0S688|B0S688_DANRE rRNA adenine N(6)-methyltransferase OS=Danio rerio OX=7955 GN=dimt1l PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.0 0.0 0.00022 0.37 3 60 .. 52 109 .. 50 159 .. 0.87
2 ? -1.7 0.0 1.7 2.9e+03 31 44 .. 246 259 .. 230 292 .. 0.68
Alignments for each domain:
== domain 1 score: 11.0 bits; conditional E-value: 0.00022
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe 60
vvl + G+G ++++ + +kv+a++ +++ ++ q+ ++ +++k+++ gdv +
tr|B0S688|B0S688_DANRE 52 VVLEVGPGTGNMTVKLLEKAKKVVACELDTRLVAELQKRVQCTPMQNKLQILIGDVLK 109
678888999999*******************************************987 PP
== domain 2 score: -1.7 bits; conditional E-value: 1.7
Methyltransf_15 31 nlsrlklaqhNaev 44
+ ++++++ hN e+
tr|B0S688|B0S688_DANRE 246 KNYKIHCSVHNIEI 259
45677788888776 PP
>> tr|X1WET5|X1WET5_DANRE THUMP domain-containing 2 OS=Danio rerio OX=7955 GN=thumpd2 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.4 0.0 0.00016 0.28 3 61 .. 253 313 .. 251 349 .. 0.81
Alignments for each domain:
== domain 1 score: 11.4 bits; conditional E-value: 0.00016
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfek..viaidinlsrlklaqhNaevYgvsdkvtlvlgdvfel 61
v+lD+++G G + a+++++ ++d++ s+l+ a +N ++ g++ +v+l + e+
tr|X1WET5|X1WET5_DANRE 253 VILDPMCGVGAVLLEAAQEYSNavFLGMDTDGSQLQKAAENVKASGMEGRVQLLQSSALEI 313
79****************987622479*************************999887774 PP
>> tr|A0A2R8RIC7|A0A2R8RIC7_DANRE Uncharacterized protein OS=Danio rerio OX=7955 GN=thumpd2 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.4 0.0 0.00016 0.28 3 61 .. 253 313 .. 251 349 .. 0.81
Alignments for each domain:
== domain 1 score: 11.4 bits; conditional E-value: 0.00016
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfek..viaidinlsrlklaqhNaevYgvsdkvtlvlgdvfel 61
v+lD+++G G + a+++++ ++d++ s+l+ a +N ++ g++ +v+l + e+
tr|A0A2R8RIC7|A0A2R8RIC7_DANRE 253 VILDPMCGVGAVLLEAAQEYSNavFLGMDTDGSQLQKAAENVKASGMEGRVQLLQSSALEI 313
79****************987622479*************************999887774 PP
>> tr|F1QJH5|F1QJH5_DANRE HemK methyltransferase family member 1 OS=Danio rerio OX=7955 GN=hemk1 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.0 0.0 0.00022 0.37 8 80 .. 170 244 .. 165 246 .. 0.81
Alignments for each domain:
== domain 1 score: 11.0 bits; conditional E-value: 0.00022
Methyltransf_15 8 fgGaGGnviqfanv..fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpP 80
+G+G + + ++ +v+a+d +++ + l+ +Na+ g +d++++ + dv + + ++ vd+++ pP
tr|F1QJH5|F1QJH5_DANRE 170 GCGSGAISLSLLRSlpQLRVFALDQSQDAVCLTMENANRLGLQDRLEVHHLDVVKDADVILSKCNPVDFIVSNPP 244
4455544444444455458************************************98887777778899999999 PP
>> tr|A0A2R8Q1A0|A0A2R8Q1A0_DANRE Uncharacterized protein OS=Danio rerio OX=7955 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.2 0.0 0.00018 0.31 4 47 .. 45 88 .. 42 92 .. 0.89
Alignments for each domain:
== domain 1 score: 11.2 bits; conditional E-value: 0.00018
Methyltransf_15 4 vlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgv 47
+D+ +G+G + +a f++v++ di++ +l++ + ++ +v
tr|A0A2R8Q1A0|A0A2R8Q1A0_DANRE 45 AVDVGCGSGQGTLLLAPHFTRVVGTDISPAQLEMGRKHVNIPNV 88
69******************************999888777655 PP
>> tr|Q504A2|Q504A2_DANRE Zgc:109986 OS=Danio rerio OX=7955 GN=zgc:109986 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.7 0.0 0.00026 0.44 24 70 .. 169 215 .. 159 224 .. 0.85
Alignments for each domain:
== domain 1 score: 10.7 bits; conditional E-value: 0.00026
Methyltransf_15 24 kviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei 70
+ ++++++ + +kl e Yg sd+++++++d+ + +a ++++ +
tr|Q504A2|Q504A2_DANRE 169 QLVGVEMSSEFVKLQSMAVEKYGFSDRIQVIHADIRSQIALVQKADV 215
57899********************************9999888776 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (165 nodes)
Target sequences: 25687 (13798380 residues searched)
Passed MSV filter: 740 (0.0288083); expected 513.7 (0.02)
Passed bias filter: 599 (0.0233192); expected 513.7 (0.02)
Passed Vit filter: 70 (0.00272511); expected 25.7 (0.001)
Passed Fwd filter: 15 (0.000583953); expected 0.3 (1e-05)
Initial search space (Z): 25687 [actual number of targets]
Domain search space (domZ): 15 [number of targets reported over threshold]
# CPU time: 0.21u 0.01s 00:00:00.22 Elapsed: 00:00:00.10
# Mc/sec: 22767.33
//
[ok]