# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_15.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_15 [M=165] Accession: PF09445.9 Description: RNA cap guanine-N2 methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 3.2e-41 143.0 0.1 1e-40 141.4 0.0 1.9 2 sp|Q96RS0|TGS1_HUMAN Trimethylguanosine synthase OS=Homo 0.0017 20.4 0.0 0.0029 19.6 0.0 1.3 1 sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member 0.005 18.8 0.0 0.0073 18.3 0.0 1.2 1 sp|P21964-2|COMT_HUMAN Isoform Soluble of Catechol O-methyl 0.0051 18.8 0.0 0.0075 18.2 0.0 1.2 1 tr|E7EMS6|E7EMS6_HUMAN Catechol O-methyltransferase (Fragme 0.0057 18.6 0.0 0.0083 18.1 0.0 1.2 1 tr|E7EUU8|E7EUU8_HUMAN Catechol O-methyltransferase OS=Homo 0.0074 18.3 0.0 0.011 17.7 0.0 1.2 1 sp|P21964|COMT_HUMAN Catechol O-methyltransferase OS=Homo 0.0089 18.0 0.0 0.018 17.0 0.0 1.5 1 sp|Q32P41|TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransfer ------ inclusion threshold ------ 0.012 17.6 0.0 0.021 16.8 0.0 1.4 1 sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyl 0.014 17.4 0.0 0.024 16.6 0.0 1.3 1 sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase h 0.023 16.7 0.1 0.043 15.8 0.0 1.5 1 tr|H0Y768|H0Y768_HUMAN tRNA (guanine(10)-N2)-methyltransfer 0.065 15.2 0.1 0.19 13.7 0.1 1.8 2 tr|F2Z2Q4|F2Z2Q4_HUMAN tRNA (guanine(10)-N2)-methyltransfer 0.07 15.1 0.0 0.11 14.4 0.0 1.3 1 sp|Q9NZJ6|COQ3_HUMAN Hexaprenyldihydroxybenzoate methyltr 0.11 14.5 0.0 0.28 13.1 0.0 1.8 2 sp|Q7Z4G4-2|TRM11_HUMAN Isoform 2 of tRNA (guanine(10)-N2)-m 0.11 14.4 0.0 0.29 13.1 0.0 1.8 2 sp|Q7Z4G4|TRM11_HUMAN tRNA (guanine(10)-N2)-methyltransfer 0.15 14.0 0.3 0.45 12.5 0.2 1.7 2 sp|Q7Z4G4-3|TRM11_HUMAN Isoform 3 of tRNA (guanine(10)-N2)-m 0.31 13.0 0.0 0.63 12.0 0.0 1.5 1 sp|Q8TEA1|NSUN6_HUMAN Putative methyltransferase NSUN6 OS= 0.38 12.7 0.0 0.62 12.0 0.0 1.3 1 sp|P46087-3|NOP2_HUMAN Isoform 3 of Putative ribosomal RNA 0.45 12.5 0.0 0.69 11.9 0.0 1.4 1 sp|Q53H54|TYW2_HUMAN tRNA wybutosine-synthesizing protein 0.51 12.3 0.0 0.65 11.9 0.0 1.1 1 tr|H7C258|H7C258_HUMAN HemK methyltransferase family member 0.53 12.2 0.0 0.86 11.5 0.0 1.3 1 sp|P46087-2|NOP2_HUMAN Isoform 2 of Putative ribosomal RNA 0.53 12.2 0.0 0.87 11.5 0.0 1.3 1 sp|P46087|NOP2_HUMAN Putative ribosomal RNA methyltransfe 0.54 12.2 0.0 2.2 10.2 0.0 2.0 2 sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS 0.56 12.1 0.0 0.92 11.5 0.0 1.3 1 sp|P46087-4|NOP2_HUMAN Isoform 4 of Putative ribosomal RNA 0.63 12.0 0.0 1.7 10.6 0.0 1.8 1 tr|H0YHL7|H0YHL7_HUMAN Coronin-1C (Fragment) OS=Homo sapien 1.5 10.8 1.4 32 6.4 1.4 2.8 1 tr|H7BXE2|H7BXE2_HUMAN C-type lectin domain family 4 member Domain annotation for each sequence (and alignments): >> sp|Q96RS0|TGS1_HUMAN Trimethylguanosine synthase OS=Homo sapiens GN=TGS1 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -2.1 0.0 3.8 1.4e+04 70 97 .. 146 174 .. 116 196 .. 0.68 2 ! 141.4 0.0 2.9e-44 1e-40 2 163 .. 692 843 .. 691 845 .. 0.93 Alignments for each domain: == domain 1 score: -2.1 bits; conditional E-value: 3.8 Methyltransf_15 70 ikvdlvflS.pPwGGpsYkkkekfdlekk 97 + d +++S P +Y+++ +++l++k sp|Q96RS0|TGS1_HUMAN 146 YEEDDILASdDPSSIEQYENTRTYELQSK 174 43444444424666678999999999764 PP == domain 2 score: 141.4 bits; conditional E-value: 2.9e-44 Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwGGpsYkkke 90 vv+D+f+G GGn+iqfa++ +viaidi++ +++la +NaevYg++dk+++++gd+ l ++lk d+vflSpPwGGp+Y e sp|Q96RS0|TGS1_HUMAN 692 DVVVDAFCGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLASFLK-----ADVVFLSPPWGGPDYATAE 775 689******************************************************97777643.....489**************** PP Methyltransf_15 91 kfdlekkleplklekllkesvklskniilfLPrnsdlkqlaaltaevlenaskvkvvklkenglvkallaylg 163 +fd+++ ++p + ++++ s k+++ni+ fLPrn+d++q+a+l +++ +v++ + n+ +k+++ay+g sp|Q96RS0|TGS1_HUMAN 776 TFDIRTMMSPDGF-EIFRLSKKITNNIVYFLPRNADIDQVASL----AGPGGQVEIEQNFLNNKLKTITAYFG 843 ****878877665.699***********************998....89***********************8 PP >> sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member 1 OS=Homo sapiens GN=HEMK1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.6 0.0 8.1e-07 0.0029 4 80 .. 163 241 .. 161 253 .. 0.82 Alignments for each domain: == domain 1 score: 19.6 bits; conditional E-value: 8.1e-07 Methyltransf_15 4 vlDlfgGaGGnviqfanv..fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpP 80 +l + +G+G + + + ++via+d+ + + l+++Na+ +d++++++ d+++ + ++l +dl++ pP sp|Q9Y5R4|HEMK1_HUMAN 163 ILEVGCGSGAISLSLLSQlpQSRVIAVDKREAAISLTHENAQRLRLQDRIWIIHLDMTSERSWTHLPWGPMDLIVSNPP 241 56666666666655555466789**********************************9976666666666699999998 PP >> sp|P21964-2|COMT_HUMAN Isoform Soluble of Catechol O-methyltransferase OS=Homo sapiens GN=COMT # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.3 0.0 2.1e-06 0.0073 6 77 .. 64 140 .. 60 142 .. 0.86 Alignments for each domain: == domain 1 score: 18.3 bits; conditional E-value: 2.1e-06 Methyltransf_15 6 DlfgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei..kvdlvfl 77 l + +G ++ +a+ + i+i+in++ +++q+ + gv+dkvtlv+g ++++ +lk++ + d+vfl sp|P21964-2|COMT_HUMAN 64 ELGAYCGYSAVRMARLlspGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDvdTLDMVFL 140 5556677888899988777889**************************************99998876568899996 PP >> tr|E7EMS6|E7EMS6_HUMAN Catechol O-methyltransferase (Fragment) OS=Homo sapiens GN=COMT PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.2 0.0 2.1e-06 0.0075 6 77 .. 114 190 .. 110 192 .. 0.86 Alignments for each domain: == domain 1 score: 18.2 bits; conditional E-value: 2.1e-06 Methyltransf_15 6 DlfgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei..kvdlvfl 77 l + +G ++ +a+ + i+i+in++ +++q+ + gv+dkvtlv+g ++++ +lk++ + d+vfl tr|E7EMS6|E7EMS6_HUMAN 114 ELGAYCGYSAVRMARLlspGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDvdTLDMVFL 190 5556677788899988777889**************************************99998876568899996 PP >> tr|E7EUU8|E7EUU8_HUMAN Catechol O-methyltransferase OS=Homo sapiens GN=COMT PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.1 0.0 2.4e-06 0.0083 6 77 .. 114 190 .. 110 192 .. 0.86 Alignments for each domain: == domain 1 score: 18.1 bits; conditional E-value: 2.4e-06 Methyltransf_15 6 DlfgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei..kvdlvfl 77 l + +G ++ +a+ + i+i+in++ +++q+ + gv+dkvtlv+g ++++ +lk++ + d+vfl tr|E7EUU8|E7EUU8_HUMAN 114 ELGAYCGYSAVRMARLlspGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDvdTLDMVFL 190 5556677788889988777889*************************************999998876568899996 PP >> sp|P21964|COMT_HUMAN Catechol O-methyltransferase OS=Homo sapiens GN=COMT PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.7 0.0 3.1e-06 0.011 6 77 .. 114 190 .. 110 192 .. 0.86 Alignments for each domain: == domain 1 score: 17.7 bits; conditional E-value: 3.1e-06 Methyltransf_15 6 DlfgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei..kvdlvfl 77 l + +G ++ +a+ + i+i+in++ +++q+ + gv+dkvtlv+g ++++ +lk++ + d+vfl sp|P21964|COMT_HUMAN 114 ELGAYCGYSAVRMARLlspGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDvdTLDMVFL 190 5556677788889988777889*************************************999998876568899996 PP >> sp|Q32P41|TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens GN=TRMT5 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.0 0.0 5.2e-06 0.018 3 64 .. 301 362 .. 299 395 .. 0.87 Alignments for each domain: == domain 1 score: 17.0 bits; conditional E-value: 5.2e-06 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellak 64 v+ D+f+G G +i +a+ ++v+a d n++ k N+++ v++kv++ d ++ l+ sp|Q32P41|TRM5_HUMAN 301 VLFDVFAGVGPFAIPVAKKNCTVFANDLNPESHKWLLYNCKLNKVDQKVKVFNLDGKDFLQG 362 689***********************************************999888776655 PP >> sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.8 0.0 5.9e-06 0.021 3 83 .. 435 515 .. 433 519 .. 0.83 Alignments for each domain: == domain 1 score: 16.8 bits; conditional E-value: 5.9e-06 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlv.flSpPwGG 83 +vlD+++G+G ++a+ ++vi+++ ++ ++ a Na+ ++v++ +g ++l+ +l ++ ++ lv +l pP G sp|Q8IZ69-2|TRM2A_HUMAN 435 MVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDN-ELSNVEFHCGRAEDLVPTLVSRLASQHLVaILDPPRAG 515 79***************************************87.5689*****99999877766665544444256777666 PP >> sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.6 0.0 6.8e-06 0.024 3 83 .. 435 515 .. 433 519 .. 0.83 Alignments for each domain: == domain 1 score: 16.6 bits; conditional E-value: 6.8e-06 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlv.flSpPwGG 83 +vlD+++G+G ++a+ ++vi+++ ++ ++ a Na+ ++v++ +g ++l+ +l ++ ++ lv +l pP G sp|Q8IZ69|TRM2A_HUMAN 435 MVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDN-ELSNVEFHCGRAEDLVPTLVSRLASQHLVaILDPPRAG 515 79***************************************87.5679*****99999877766665544444256777666 PP >> tr|H0Y768|H0Y768_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog (Fragment) OS=Homo sapiens GN=TRMT11 PE=4 SV= # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.8 0.0 1.2e-05 0.043 3 51 .. 17 69 .. 15 120 .. 0.74 Alignments for each domain: == domain 1 score: 15.8 bits; conditional E-value: 1.2e-05 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrl....klaqhNaevYgvsdkv 51 +v D+f G+GG i+ a+ v++ di+ +++ k + +N + g ++++ tr|H0Y768|H0Y768_HUMAN 17 IVFDPFVGTGGLLIACAHFGAYVYGTDIDYNTVhglgKATRKNQKWRGPDENI 69 789**************************999833334566666666655555 PP >> tr|F2Z2Q4|F2Z2Q4_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -2.5 0.0 5.1 1.8e+04 43 64 .. 91 112 .. 80 128 .. 0.62 2 ? 13.7 0.1 5.2e-05 0.19 3 43 .. 218 262 .. 216 315 .. 0.76 Alignments for each domain: == domain 1 score: -2.5 bits; conditional E-value: 5.1 Methyltransf_15 43 evYgvsdkvtlvlgdvfellak 64 + Y v++ v + + d + ++ tr|F2Z2Q4|F2Z2Q4_HUMAN 91 KNYPVEKMVPFLHSDSTYKIKI 112 4466666666666665554444 PP == domain 2 score: 13.7 bits; conditional E-value: 5.2e-05 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrl....klaqhNae 43 +v D+f G+GG i+ a+ v++ di+ +++ k + +N + tr|F2Z2Q4|F2Z2Q4_HUMAN 218 IVFDPFVGTGGLLIACAHFGAYVYGTDIDYNTVhglgKATRKNQK 262 789**************************9998333334555555 PP >> sp|Q9NZJ6|COQ3_HUMAN Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial OS=Homo sapiens GN=COQ3 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.4 0.0 3.2e-05 0.11 3 78 .. 149 222 .. 147 225 .. 0.87 Alignments for each domain: == domain 1 score: 14.4 bits; conditional E-value: 3.2e-05 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgv.sdkvtlvlgdvfellaklkleeikvdlvflS 78 +lD+ +G+G + + + +vi+id +++k aq + v ++++++ ++ ++e+++++ e+ +d v++S sp|Q9NZJ6|COQ3_HUMAN 149 KILDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQCHKSFDPVlDKRIEYRVCSLEEIVEET-AET--FDAVVAS 222 58*****************************999999888888886899************983.333..4888887 PP >> sp|Q7Z4G4-2|TRM11_HUMAN Isoform 2 of tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -3.4 0.0 9.3 3.3e+04 43 64 .. 91 112 .. 82 123 .. 0.60 2 ? 13.1 0.0 8e-05 0.28 3 43 .. 218 262 .. 216 316 .. 0.77 Alignments for each domain: == domain 1 score: -3.4 bits; conditional E-value: 9.3 Methyltransf_15 43 evYgvsdkvtlvlgdvfellak 64 + Y v++ v + + d + ++ sp|Q7Z4G4-2|TRM11_HUMAN 91 KNYPVEKMVPFLHSDSTYKIKI 112 4466666666666665554444 PP == domain 2 score: 13.1 bits; conditional E-value: 8e-05 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrl....klaqhNae 43 +v D+f G+GG i+ a+ v++ di+ +++ k + +N + sp|Q7Z4G4-2|TRM11_HUMAN 218 IVFDPFVGTGGLLIACAHFGAYVYGTDIDYNTVhglgKATRKNQK 262 789**************************9998333334555555 PP >> sp|Q7Z4G4|TRM11_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -3.4 0.0 9.5 3.4e+04 43 64 .. 91 112 .. 82 123 .. 0.60 2 ? 13.1 0.0 8.1e-05 0.29 3 43 .. 218 262 .. 216 316 .. 0.77 Alignments for each domain: == domain 1 score: -3.4 bits; conditional E-value: 9.5 Methyltransf_15 43 evYgvsdkvtlvlgdvfellak 64 + Y v++ v + + d + ++ sp|Q7Z4G4|TRM11_HUMAN 91 KNYPVEKMVPFLHSDSTYKIKI 112 4466666666666665554444 PP == domain 2 score: 13.1 bits; conditional E-value: 8.1e-05 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrl....klaqhNae 43 +v D+f G+GG i+ a+ v++ di+ +++ k + +N + sp|Q7Z4G4|TRM11_HUMAN 218 IVFDPFVGTGGLLIACAHFGAYVYGTDIDYNTVhglgKATRKNQK 262 789**************************9998333334555555 PP >> sp|Q7Z4G4-3|TRM11_HUMAN Isoform 3 of tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.7 0.0 2.9 1e+04 43 65 .. 91 113 .. 75 131 .. 0.64 2 ? 12.5 0.2 0.00013 0.45 3 35 .. 218 250 .. 216 255 .. 0.91 Alignments for each domain: == domain 1 score: -1.7 bits; conditional E-value: 2.9 Methyltransf_15 43 evYgvsdkvtlvlgdvfellakl 65 + Y v++ v + + d + ++ sp|Q7Z4G4-3|TRM11_HUMAN 91 KNYPVEKMVPFLHSDSTYKIKIH 113 34666666666666655544444 PP == domain 2 score: 12.5 bits; conditional E-value: 0.00013 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrl 35 +v D+f G+GG i+ a+ v++ di+ +++ sp|Q7Z4G4-3|TRM11_HUMAN 218 IVFDPFVGTGGLLIACAHFGAYVYGTDIDYNTV 250 789*************************99886 PP >> sp|Q8TEA1|NSUN6_HUMAN Putative methyltransferase NSUN6 OS=Homo sapiens GN=NSUN6 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.0 0.0 0.00018 0.63 3 48 .. 237 285 .. 235 309 .. 0.81 Alignments for each domain: == domain 1 score: 12.0 bits; conditional E-value: 0.00018 Methyltransf_15 3 vvlDlfgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvs 48 +lDl++ GG++ ++a +via+d+ +++++ +++Na + g + sp|Q8TEA1|NSUN6_HUMAN 237 KILDLCAAPGGKTTHIAALmhdQGEVIALDKIFNKVEKIKQNALLLGLN 285 79**************998444347******************888654 PP >> sp|P46087-3|NOP2_HUMAN Isoform 3 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.0 0.0 0.00017 0.62 2 52 .. 382 435 .. 381 469 .. 0.87 Alignments for each domain: == domain 1 score: 12.0 bits; conditional E-value: 0.00017 Methyltransf_15 2 evvlDlfgGaGGnviqfanvfek...viaidinlsrlklaqhNaevYgvsdkvt 52 e +lD+++ GG++ +a+ ++ + a d n +rlk + N + gv + + sp|P46087-3|NOP2_HUMAN 382 ERILDMCCAPGGKTSYMAQLMKNtgvILANDANAERLKSVVGNLHRLGVTNTII 435 579***************996652226788***************999988875 PP >> sp|Q53H54|TYW2_HUMAN tRNA wybutosine-synthesizing protein 2 homolog OS=Homo sapiens GN=TRMT12 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.0 0.00019 0.69 2 60 .. 236 296 .. 235 370 .. 0.83 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.00019 Methyltransf_15 2 evvlDlfgGaGGnviqfanv....fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe 60 ev++Dl++G G + f f v+a++ n++ + +N e+ gv+d+ ++ gd + sp|Q53H54|TYW2_HUMAN 236 EVLVDLYAGIGYFTLPFLVHagaaF--VHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRK 296 5789999999999999977666445..********************************9876 PP >> tr|H7C258|H7C258_HUMAN HemK methyltransferase family member 1 (Fragment) OS=Homo sapiens GN=HEMK1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.0 0.00018 0.65 7 46 .. 4 45 .. 1 51 [. 0.76 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.00018 Methyltransf_15 7 lfgGaGGnviqfanv..fekviaidinlsrlklaqhNaevYg 46 + +G+G + + + ++via+d+ + + l+++Na+ Y+ tr|H7C258|H7C258_HUMAN 4 VGCGSGAISLSLLSQlpQSRVIAVDKREAAISLTHENAQSYE 45 55555555554444466789*********************5 PP >> sp|P46087-2|NOP2_HUMAN Isoform 2 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.5 0.0 0.00024 0.86 2 52 .. 382 435 .. 381 468 .. 0.87 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 0.00024 Methyltransf_15 2 evvlDlfgGaGGnviqfanvfek...viaidinlsrlklaqhNaevYgvsdkvt 52 e +lD+++ GG++ +a+ ++ + a d n +rlk + N + gv + + sp|P46087-2|NOP2_HUMAN 382 ERILDMCCAPGGKTSYMAQLMKNtgvILANDANAERLKSVVGNLHRLGVTNTII 435 579***************996652226788***************999988875 PP >> sp|P46087|NOP2_HUMAN Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.5 0.0 0.00025 0.87 2 52 .. 386 439 .. 385 472 .. 0.87 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 0.00025 Methyltransf_15 2 evvlDlfgGaGGnviqfanvfek...viaidinlsrlklaqhNaevYgvsdkvt 52 e +lD+++ GG++ +a+ ++ + a d n +rlk + N + gv + + sp|P46087|NOP2_HUMAN 386 ERILDMCCAPGGKTSYMAQLMKNtgvILANDANAERLKSVVGNLHRLGVTNTII 439 579***************996652226788***************999988875 PP >> sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS=Homo sapiens GN=THUMPD2 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -2.0 0.0 3.6 1.3e+04 45 69 .. 45 68 .. 38 77 .. 0.82 2 ? 10.2 0.0 0.00062 2.2 3 82 .. 301 378 .. 299 397 .. 0.84 Alignments for each domain: == domain 1 score: -2.0 bits; conditional E-value: 3.6 Methyltransf_15 45 Ygvsdkvtlvlgdvfellaklklee 69 Y +s kv++ ++ ++l+klk++e sp|Q9BTF0|THUM2_HUMAN 45 Y-ISGKVFFTTCSDLNMLKKLKSAE 68 4.78899999999999999999876 PP == domain 2 score: 10.2 bits; conditional E-value: 0.00062 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekvi..aidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwG 82 vlD+++G G + a++++ v+ + d++ s+l + N ++ g +dk++l + v el +e++ d+++ +P G sp|Q9BTF0|THUM2_HUMAN 301 FVLDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPL--PSESV--DIIISDIPFG 378 68********************984467889999999****************9999888643..34444..7777777776 PP >> sp|P46087-4|NOP2_HUMAN Isoform 4 of Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.5 0.0 0.00026 0.92 2 52 .. 419 472 .. 418 504 .. 0.87 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 0.00026 Methyltransf_15 2 evvlDlfgGaGGnviqfanvfek...viaidinlsrlklaqhNaevYgvsdkvt 52 e +lD+++ GG++ +a+ ++ + a d n +rlk + N + gv + + sp|P46087-4|NOP2_HUMAN 419 ERILDMCCAPGGKTSYMAQLMKNtgvILANDANAERLKSVVGNLHRLGVTNTII 472 579***************996652226788***************999988875 PP >> tr|H0YHL7|H0YHL7_HUMAN Coronin-1C (Fragment) OS=Homo sapiens GN=CORO1C PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.6 0.0 0.00049 1.7 80 145 .. 4 112 .. 2 163 .. 0.74 Alignments for each domain: == domain 1 score: 10.6 bits; conditional E-value: 0.00049 Methyltransf_15 80 PwGGpsYkkkekfdlekkleplklekllkesvklskniilfLPrnsdlkql.................................... 130 P G+ Y k +d+ +++++ + +k ++++ ii+ Pr+sdl q tr|H0YHL7|H0YHL7_HUMAN 4 PQRGMGYMPKRGLDV----NKCEIARFFKLHERKCEPIIMTVPRKSDLFQDdlypdtagpeaaleaeewfegknadpilislkhgyi 86 777999999999999....8999************************9654346666666666666666666666666666666666 PP Methyltransf_15 131 ...........aaltaevlenaskvk 145 ++++ + ++ ++k++ tr|H0YHL7|H0YHL7_HUMAN 87 pgknrdlkvvkKNILDSKPTANKKCD 112 66666666666444444444444444 PP >> tr|H7BXE2|H7BXE2_HUMAN C-type lectin domain family 4 member M OS=Homo sapiens GN=CLEC4M PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 6.4 1.4 0.0092 32 99 138 .. 105 144 .. 90 263 .. 0.82 Alignments for each domain: == domain 1 score: 6.4 bits; conditional E-value: 0.0092 Methyltransf_15 99 eplklekllkesvklskniilfLPrnsdlkqlaaltaevl 138 e+ kl+++++e ++l+ ++ LP +s+l+++++ ++++ tr|H7BXE2|H7BXE2_HUMAN 105 EKSKLQEIYQELTQLKAAVVGELPEKSKLQEIYQELTRLK 144 6789999999*********************955544443 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (165 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 2126 (0.0240299); expected 1769.5 (0.02) Passed bias filter: 1802 (0.0203678); expected 1769.5 (0.02) Passed Vit filter: 157 (0.00177455); expected 88.5 (0.001) Passed Fwd filter: 25 (0.000282572); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 25 [number of targets reported over threshold] # CPU time: 0.52u 0.02s 00:00:00.54 Elapsed: 00:00:00.23 # Mc/sec: 25159.28 // [ok]