# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_15.hmm.txt # target sequence database: proteomes/Macaca_mulatta.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_15 [M=165] Accession: PF09445.9 Description: RNA cap guanine-N2 methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 1.5e-38 132.3 0.0 4e-38 131.0 0.0 1.8 1 tr|F7G2A0|F7G2A0_MACMU Trimethylguanosine synthase 1 OS 8.6e-05 22.5 0.0 0.00019 21.4 0.0 1.6 1 tr|A0A1I7Q472|A0A1I7Q472_MACMU tRNA (guanine(37)-N1)-methyltran 8.9e-05 22.5 0.0 0.0002 21.3 0.0 1.6 1 sp|F7GSQ4|TRM5_MACMU tRNA (guanine(37)-N1)-methyltran 0.00046 20.2 0.0 0.00074 19.5 0.0 1.2 1 tr|A0A1D5RD03|A0A1D5RD03_MACMU HemK methyltransferase family me 0.0044 17.0 0.0 0.0077 16.2 0.0 1.3 1 tr|H9FSY6|H9FSY6_MACMU tRNA (Uracil-5-)-methyltransfera ------ inclusion threshold ------ 0.021 14.7 0.0 0.032 14.2 0.0 1.2 1 tr|F6QFW9|F6QFW9_MACMU Catechol O-methyltransferase iso 0.045 13.7 0.0 0.12 12.3 0.0 1.8 2 tr|F6ZLG8|F6ZLG8_MACMU tRNA guanosine-2'-O-methyltransf 0.059 13.3 0.0 0.1 12.6 0.0 1.4 1 tr|F6SWB4|F6SWB4_MACMU NOP2/Sun RNA methyltransferase f 0.074 13.0 0.0 0.1 12.5 0.0 1.4 1 tr|F6YP41|F6YP41_MACMU tRNA methyltransferase 12 homolo 0.098 12.6 0.0 0.36 10.8 0.0 1.9 2 tr|F7H715|F7H715_MACMU THUMP domain containing 2 OS=Mac 0.13 12.2 0.0 0.22 11.4 0.0 1.3 1 tr|F6ZSG5|F6ZSG5_MACMU NOP2 nucleolar protein OS=Macaca Domain annotation for each sequence (and alignments): >> tr|F7G2A0|F7G2A0_MACMU Trimethylguanosine synthase 1 OS=Macaca mulatta OX=9544 GN=TGS1 PE=4 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 131.0 0.0 2.1e-41 4e-38 2 163 .. 694 841 .. 693 843 .. 0.91 Alignments for each domain: == domain 1 score: 131.0 bits; conditional E-value: 2.1e-41 Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwGGpsYkk 88 vv+D+f+G GGn+iqfa++ +viaidi++ +++la +NaevYg++dk+++++gd+ l a l k d+vflSpPwGGp+Y tr|F7G2A0|F7G2A0_MACMU 694 DVVVDAFCGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLAACL-----KADVVFLSPPWGGPDYAT 775 689*****************************************************99766654.....4589************** PP Methyltransf_15 89 kekfdlekkleplklekllkesvklskniilfLPrnsdlkqlaaltaevlenaskvkvvklkenglvkallaylg 163 e+fd+++ ++p + l k+++ni+ fLPrn+d++q+a+l +++ +v++ + n+ +k+++ay+g tr|F7G2A0|F7G2A0_MACMU 776 AETFDIRTMMSP-DGYPL----EKITNNIVYFLPRNADIDQVASL----AGPGGQVEIEQNFLNNKLKTITAYFG 841 ******777776.44444....4689****************998....89***********************8 PP >> tr|A0A1I7Q472|A0A1I7Q472_MACMU tRNA (guanine(37)-N1)-methyltransferase OS=Macaca mulatta OX=9544 GN=TRMT5 PE=3 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.4 0.0 9.8e-08 0.00019 3 67 .. 280 344 .. 278 375 .. 0.86 Alignments for each domain: == domain 1 score: 21.4 bits; conditional E-value: 9.8e-08 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkl 67 v+ D+f+G G +i +a+ ++v+a d n++ k hN+++ v++kv++ d ++ l+ + tr|A0A1I7Q472|A0A1I7Q472_MACMU 280 VLFDVFAGVGPFAIPVAKKNCTVFANDLNPESHKWLLHNCKLNKVDQKVKIFNLDGKDFLQGPVK 344 689***********************************************999888886655444 PP >> sp|F7GSQ4|TRM5_MACMU tRNA (guanine(37)-N1)-methyltransferase OS=Macaca mulatta OX=9544 GN=TRMT5 PE=3 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.3 0.0 1e-07 0.0002 3 67 .. 301 365 .. 299 396 .. 0.86 Alignments for each domain: == domain 1 score: 21.3 bits; conditional E-value: 1e-07 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkl 67 v+ D+f+G G +i +a+ ++v+a d n++ k hN+++ v++kv++ d ++ l+ + sp|F7GSQ4|TRM5_MACMU 301 VLFDVFAGVGPFAIPVAKKNCTVFANDLNPESHKWLLHNCKLNKVDQKVKIFNLDGKDFLQGPVK 365 689***********************************************999888886655444 PP >> tr|A0A1D5RD03|A0A1D5RD03_MACMU HemK methyltransferase family member 1 OS=Macaca mulatta OX=9544 GN=HEMK1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.5 0.0 3.8e-07 0.00074 4 80 .. 206 284 .. 204 291 .. 0.81 Alignments for each domain: == domain 1 score: 19.5 bits; conditional E-value: 3.8e-07 Methyltransf_15 4 vlDlfgGaGGnviqfanv..fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpP 80 +l + +G+G + + + ++via+d+ + + l+++Na+ + +d++++++ d+++ + ++l vdlv+ pP tr|A0A1D5RD03|A0A1D5RD03_MACMU 206 ILEVGCGSGAISLSLLSQlpQSRVIAVDKGEAAISLTHENAQRLQLQDRIWIIHLDMTSERSWTHLPWGPVDLVISNPP 284 56666666666655555466789**********************************9966666666656699999888 PP >> tr|H9FSY6|H9FSY6_MACMU tRNA (Uracil-5-)-methyltransferase homolog A OS=Macaca mulatta OX=9544 GN=TRMT2A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 16.2 0.0 4e-06 0.0077 3 83 .. 435 515 .. 433 519 .. 0.82 Alignments for each domain: == domain 1 score: 16.2 bits; conditional E-value: 4e-06 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlv.flSpPwGG 83 +vlD+++G+G ++a+ ++vi+++ ++ ++ a Na+ ++v++ +g ++l+ l ++ ++ lv +l pP G tr|H9FSY6|H9FSY6_MACMU 435 TVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDN-ELSNVEFHCGRAEDLVPALVSRLASQHLVaILDPPRAG 515 69***************************************87.56799**9999999777766665544444256677666 PP >> tr|F6QFW9|F6QFW9_MACMU Catechol O-methyltransferase isoform MB-COMT OS=Macaca mulatta OX=9544 GN=COMT PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.2 0.0 1.7e-05 0.032 8 77 .. 115 189 .. 109 191 .. 0.86 Alignments for each domain: == domain 1 score: 14.2 bits; conditional E-value: 1.7e-05 Methyltransf_15 8 fgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei..kvdlvfl 77 + +G ++ +a+ + +i+in++ +++q+ + g++dkvt+v+g ++++ +lk++ + d+vfl tr|F6QFW9|F6QFW9_MACMU 115 GAYCGYSAVRMARLlspGARLLTIEINPDYAAITQRMVDFAGMQDKVTVVVGASQDIIPQLKKKYDvdTLDMVFL 189 555777788888887777899************************************999998876568899996 PP >> tr|F6ZLG8|F6ZLG8_MACMU tRNA guanosine-2'-O-methyltransferase TRM11 homolog OS=Macaca mulatta OX=9544 GN=TRMT11 PE=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -3.4 0.0 4.2 8.2e+03 43 63 .. 91 111 .. 82 122 .. 0.59 2 ? 12.3 0.0 6.4e-05 0.12 3 43 .. 218 262 .. 216 319 .. 0.77 Alignments for each domain: == domain 1 score: -3.4 bits; conditional E-value: 4.2 Methyltransf_15 43 evYgvsdkvtlvlgdvfella 63 + Y v++ v + + d + ++ tr|F6ZLG8|F6ZLG8_MACMU 91 KNYPVEKMVPFLHSDSTYKIK 111 446666666666666555444 PP == domain 2 score: 12.3 bits; conditional E-value: 6.4e-05 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrl....klaqhNae 43 +v D+f G+GG i+ a+ v++ di+ +++ k + +N + tr|F6ZLG8|F6ZLG8_MACMU 218 IVFDPFVGTGGLLIASAHFGAYVYGTDIDYNTVhglgKATRKNQK 262 789**************************9998333334555555 PP >> tr|F6SWB4|F6SWB4_MACMU NOP2/Sun RNA methyltransferase family member 6 OS=Macaca mulatta OX=9544 GN=NSUN6 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.6 0.0 5.2e-05 0.1 3 48 .. 237 285 .. 235 339 .. 0.85 Alignments for each domain: == domain 1 score: 12.6 bits; conditional E-value: 5.2e-05 Methyltransf_15 3 vvlDlfgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvs 48 +lDl++ GG++ ++a +via+d+ +s+++ +++Na + g + tr|F6SWB4|F6SWB4_MACMU 237 KILDLCAAPGGKTTHIAALmhdQGEVIAMDKIFSKVEKIKQNALLLGLN 285 79**************998444347******************888664 PP >> tr|F6YP41|F6YP41_MACMU tRNA methyltransferase 12 homolog OS=Macaca mulatta OX=9544 GN=TRMT12 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.5 0.0 5.4e-05 0.1 2 61 .. 236 307 .. 235 422 .. 0.79 Alignments for each domain: == domain 1 score: 12.5 bits; conditional E-value: 5.4e-05 Methyltransf_15 2 evvlDlfgGaGGnviqfanv....fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe..........l 61 ev++Dl++G G + f f v+a++ n++ + +N e+ gv+d+ ++ gd + + tr|F6YP41|F6YP41_MACMU 236 EVLVDLYAGIGYFTLPFLVHagaaF--VHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKlklsniadrvI 307 5789999999999999977666445..*********************************87754444444441 PP >> tr|F7H715|F7H715_MACMU THUMP domain containing 2 OS=Macaca mulatta OX=9544 GN=THUMPD2 PE=4 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -2.1 0.0 1.7 3.3e+03 45 69 .. 45 68 .. 39 74 .. 0.82 2 ? 10.8 0.0 0.00019 0.36 3 82 .. 301 378 .. 299 400 .. 0.84 Alignments for each domain: == domain 1 score: -2.1 bits; conditional E-value: 1.7 Methyltransf_15 45 Ygvsdkvtlvlgdvfellaklklee 69 Y +s kv++ ++ ++l+klk++e tr|F7H715|F7H715_MACMU 45 Y-ISGKVFFTTCSDLNMLKKLKSAE 68 4.78899999999999999999876 PP == domain 2 score: 10.8 bits; conditional E-value: 0.00019 Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekvi..aidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwG 82 vlD+++G G + a++++ v+ + d++ s+l + N ++ g +dk++l + v el +e++ d+++ +P G tr|F7H715|F7H715_MACMU 301 FVLDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDKIELLKVSVIELPL--PSESV--DIIISDIPFG 378 68********************984467889999999****************9999988643..34555..7777777776 PP >> tr|F6ZSG5|F6ZSG5_MACMU NOP2 nucleolar protein OS=Macaca mulatta OX=9544 GN=NOP2 PE=3 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.4 0.0 0.00012 0.22 2 52 .. 418 471 .. 417 506 .. 0.87 Alignments for each domain: == domain 1 score: 11.4 bits; conditional E-value: 0.00012 Methyltransf_15 2 evvlDlfgGaGGnviqfanvfek...viaidinlsrlklaqhNaevYgvsdkvt 52 e +lD+++ GG++ +a+ ++ + a d n +rlk + N + gv + v tr|F6ZSG5|F6ZSG5_MACMU 418 ERILDMCCAPGGKTSYMAQLMKNtgvILANDANAERLKSVVGNLHRLGVTNTVI 471 579***************996652226788***************999988775 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (165 nodes) Target sequences: 21211 (10888574 residues searched) Passed MSV filter: 590 (0.0278158); expected 424.2 (0.02) Passed bias filter: 485 (0.0228655); expected 424.2 (0.02) Passed Vit filter: 56 (0.00264014); expected 21.2 (0.001) Passed Fwd filter: 11 (0.000518599); expected 0.2 (1e-05) Initial search space (Z): 21211 [actual number of targets] Domain search space (domZ): 11 [number of targets reported over threshold] # CPU time: 0.16u 0.01s 00:00:00.17 Elapsed: 00:00:00.07 # Mc/sec: 25665.92 // [ok]