# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_15.hmm.txt
# target sequence database: proteomes/Mus_musculus.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_15 [M=165]
Accession: PF09445.9
Description: RNA cap guanine-N2 methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
1.7e-40 138.7 0.0 3.6e-40 137.7 0.0 1.6 1 sp|Q923W1|TGS1_MOUSE Trimethylguanosine synthase OS=Mus mus
1.1e-06 28.7 0.1 1.6e-06 28.3 0.1 1.2 1 sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=Mu
0.00033 20.7 0.0 0.0008 19.5 0.0 1.7 1 sp|Q9D0C4|TRM5_MOUSE tRNA (guanine(37)-N1)-methyltransferas
0.0008 19.5 0.0 0.0012 18.9 0.0 1.2 1 sp|Q8BMS4|COQ3_MOUSE Ubiquinone biosynthesis O-methyltransf
0.0071 16.4 0.0 0.013 15.6 0.0 1.3 1 sp|Q921L7|HEMK1_MOUSE HemK methyltransferase family member 1
------ inclusion threshold ------
0.043 13.8 0.0 0.058 13.4 0.0 1.2 1 sp|Q9ET26|RN114_MOUSE E3 ubiquitin-protein ligase RNF114 OS=
0.18 11.8 0.0 0.29 11.1 0.0 1.3 1 sp|Q8BG71|TYW2_MOUSE tRNA wybutosine-synthesizing protein 2
0.21 11.6 0.0 0.36 10.8 0.0 1.3 1 sp|Q3TX08|TRM1_MOUSE tRNA (guanine(26)-N(2))-dimethyltransf
Domain annotation for each sequence (and alignments):
>> sp|Q923W1|TGS1_MOUSE Trimethylguanosine synthase OS=Mus musculus OX=10090 GN=Tgs1 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 137.7 0.0 1.3e-43 3.6e-40 2 163 .. 684 835 .. 683 837 .. 0.91
Alignments for each domain:
== domain 1 score: 137.7 bits; conditional E-value: 1.3e-43
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwGGpsYkkke 90
vv+D+f+G GGn+iqfa++ ++viaidi++ ++ la +NaevYg++dk+++++gd+ l +k d+vflSpPwGGp+Y e
sp|Q923W1|TGS1_MOUSE 684 DVVVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGIADKIEFICGDFLLLAPC-----LKADVVFLSPPWGGPDYATAE 767
689*****************************************************9865544.....34589**************** PP
Methyltransf_15 91 kfdlekkleplklekllkesvklskniilfLPrnsdlkqlaaltaevlenaskvkvvklkenglvkallaylg 163
+fd+++ ++p + ++++ s k+++ni+ fLPrn+d++q+a+l ++ +v++ + n+ +k+++ay+g
sp|Q923W1|TGS1_MOUSE 768 TFDIRTMMSPDGF-EIFRLSQKITNNIVYFLPRNADIDQVASL----AGLGGQVEIEQNFLNNKLKTITAYFG 835
****878877666.699***********************998....6777788999999***********98 PP
>> sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=Mus musculus OX=10090 GN=Mettl5 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 28.3 0.1 5.7e-10 1.6e-06 3 112 .. 54 162 .. 52 182 .. 0.85
Alignments for each domain:
== domain 1 score: 28.3 bits; conditional E-value: 5.7e-10
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfe.kviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwGGpsYkkk 89
v Dl +G+G +i a+ ++ di+++ l++ ++N e + +v+++++dv +l ++ ++++ +d v++ pP G + k +
sp|Q8K1A0|METL5_MOUSE 54 AVADLGCGCGVLSIGAAMLGAgLCVGFDIDEDALEIFNKNVEEF-ELTNVDMIQCDVYSLSNR--MSKL-FDTVIMNPPFGTKNNKGT 137
567999***********996515789******************.5689*********99876..5667.8**********9999988 PP
Methyltransf_15 90 ekfdlek..kleplklekllkesvk 112
+ l++ + ++++ l k+s++
sp|Q8K1A0|METL5_MOUSE 138 DMAFLKTalGMARTAVYSLHKSSTR 162
8877877566788888888887664 PP
>> sp|Q9D0C4|TRM5_MOUSE tRNA (guanine(37)-N1)-methyltransferase OS=Mus musculus OX=10090 GN=Trmt5 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 19.5 0.0 2.9e-07 0.0008 3 62 .. 294 353 .. 292 400 .. 0.84
Alignments for each domain:
== domain 1 score: 19.5 bits; conditional E-value: 2.9e-07
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfell 62
v+ D+f+G G +i a+ ++v+a d n++ k hN+++ v++kv++ d ++ +
sp|Q9D0C4|TRM5_MOUSE 294 VLFDVFAGVGPFAIPAARKNCTVFANDLNPESHKWLLHNCKLNKVDQKVKVFNMDGKDFI 353
689***********************************************9998877743 PP
>> sp|Q8BMS4|COQ3_MOUSE Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Coq3 PE=
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.9 0.0 4.2e-07 0.0012 3 78 .. 150 223 .. 148 234 .. 0.92
Alignments for each domain:
== domain 1 score: 18.9 bits; conditional E-value: 4.2e-07
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgv.sdkvtlvlgdvfellaklkleeikvdlvflS 78
+lD+ +G+G + + + +v++id +++k+aqh + v +++++++++ ++e++ + ++e+ +d v++S
sp|Q8BMS4|COQ3_MOUSE 150 KILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVlDKRIQYKVCSLEEAVDE--SAEC-FDAVVAS 223
58**************************************999997889**********9998..6677.8888887 PP
>> sp|Q921L7|HEMK1_MOUSE HemK methyltransferase family member 1 OS=Mus musculus OX=10090 GN=Hemk1 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 15.6 0.0 4.5e-06 0.013 4 80 .. 164 243 .. 162 252 .. 0.78
Alignments for each domain:
== domain 1 score: 15.6 bits; conditional E-value: 4.5e-06
Methyltransf_15 4 vlDlfgGaGGnviqfanv..fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe..llaklkleeikvdlvflSpP 80
+l + +G+G + + + ++v+a+d+++ + l+++Na+ + +d++ +++ d+++ ++l + dlv+ pP
sp|Q921L7|HEMK1_MOUSE 164 ILEVGCGSGAITLSLLSQlpKSRVVAVDKEEAAVSLTHENAQRLQLQDRIRIIHLDITSegCCTHLLPWS-PLDLVVSNPP 243
67777777777777666656679*********************************98854344433333.3677777777 PP
>> sp|Q9ET26|RN114_MOUSE E3 ubiquitin-protein ligase RNF114 OS=Mus musculus OX=10090 GN=Rnf114 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.4 0.0 2.1e-05 0.058 31 108 .. 84 209 .. 71 225 .. 0.67
Alignments for each domain:
== domain 1 score: 13.4 bits; conditional E-value: 2.1e-05
Methyltransf_15 31 nlsrlklaqhNaevYgvsdkvtlvlgdvfe...........................................llaklkleei..... 70
+++ ++ + h ++ + +k+ + + + l++++kl +
sp|Q9ET26|RN114_MOUSE 84 QIESIETSCHGCRKNFILSKIRAHVTSCSKyqnyimegvkattkdaslqprnipnrytfpcpycpeknfdqegLVEHCKLTHStdtks 171
4556666666666665666666666666666677777777777777777888888888888888888888888555555443322111 PP
Methyltransf_15 71 kvdlvflSpPwGGpsYkkkekfdlekkleplklekllk 108
v + +S PwG psY+ + + ++ + ++ ++ ++
sp|Q9ET26|RN114_MOUSE 172 VVCPICASMPWGDPSYRSANFMEHIQRRHRFSYDTFVD 209
3445789**********999888777777777666665 PP
>> sp|Q8BG71|TYW2_MOUSE tRNA wybutosine-synthesizing protein 2 homolog OS=Mus musculus OX=10090 GN=Trmt12 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.1 0.0 0.0001 0.29 2 60 .. 226 286 .. 225 331 .. 0.86
Alignments for each domain:
== domain 1 score: 11.1 bits; conditional E-value: 0.0001
Methyltransf_15 2 evvlDlfgGaGGnviqfanv....fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe 60
ev++Dl++G G + f f v+a++ n++ + +N e+ gv+d+ ++ gd +
sp|Q8BG71|TYW2_MOUSE 226 EVLVDLYAGIGYFTLPFLVHagaaF--VHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRK 286
5789999999999999977666445..******************************999766 PP
>> sp|Q3TX08|TRM1_MOUSE tRNA (guanine(26)-N(2))-dimethyltransferase OS=Mus musculus OX=10090 GN=Trmt1 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.8 0.0 0.00013 0.36 9 76 .. 160 230 .. 153 238 .. 0.85
Alignments for each domain:
== domain 1 score: 10.8 bits; conditional E-value: 0.00013
Methyltransf_15 9 gGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvf 76
+ +G +i fa++ ++v+a d + + ++l+++N e+ gv++ v+ ++d l+ + +++ ++d++
sp|Q3TX08|TRM1_MOUSE 160 AASGLRSIRFALEvpgLQSVVANDASARAVELMHRNVELNGVAHLVQPNQADARMLMYQHQKAPERFDVID 230
5667788999999888899**********************************999988888777788885 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (165 nodes)
Target sequences: 22289 (11757923 residues searched)
Passed MSV filter: 632 (0.0283548); expected 445.8 (0.02)
Passed bias filter: 523 (0.0234645); expected 445.8 (0.02)
Passed Vit filter: 49 (0.00219839); expected 22.3 (0.001)
Passed Fwd filter: 8 (0.000358921); expected 0.2 (1e-05)
Initial search space (Z): 22289 [actual number of targets]
Domain search space (domZ): 8 [number of targets reported over threshold]
# CPU time: 0.16u 0.01s 00:00:00.17 Elapsed: 00:00:00.07
# Mc/sec: 27715.10
//
[ok]