# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_15.hmm.txt
# target sequence database: proteomes/Saccharomyces_cerevisiae.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_15 [M=165]
Accession: PF09445.9
Description: RNA cap guanine-N2 methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
8.1e-67 222.5 0.0 1.4e-66 221.8 0.0 1.4 1 sp|Q12052|TGS1_YEAST Trimethylguanosine synthase OS=Saccharo
3e-07 28.7 0.6 7e-07 27.6 0.5 1.5 1 sp|P25087|ERG6_YEAST Sterol 24-C-methyltransferase OS=Saccha
1.8e-05 23.0 0.1 4.3e-05 21.7 0.1 1.7 1 sp|P33753|TRM2_YEAST tRNA (uracil(54)-C(5))-methyltransferas
0.0022 16.2 1.1 0.32 9.2 0.1 2.3 2 sp|P11709|BIK1_YEAST Nuclear fusion protein BIK1 OS=Saccharo
------ inclusion threshold ------
0.026 12.7 0.0 0.039 12.1 0.0 1.3 1 sp|P38892|CRG1_YEAST Probable S-adenosylmethionine-dependent
0.031 12.5 0.0 0.058 11.6 0.0 1.5 1 sp|P53972|RCM1_YEAST 25S rRNA (cytosine(2278)-C(5))-methyltr
Domain annotation for each sequence (and alignments):
>> sp|Q12052|TGS1_YEAST Trimethylguanosine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 221.8 0.0 1.4e-69 1.4e-66 2 164 .. 99 261 .. 98 262 .. 0.99
Alignments for each domain:
== domain 1 score: 221.8 bits; conditional E-value: 1.4e-69
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwGGpsYkkke 90
e +lD+f+G+GGn+iqfa++f+ v+++d+++++++++ +Na+ Ygv+d+++l+ g +++l++k kl++ik+d+vf SpPwGGp+Y +++
sp|Q12052|TGS1_YEAST 99 ERILDVFCGGGGNTIQFAMQFPYVYGVDYSIEHIYCTAKNAQSYGVDDRIWLKRGSWKKLVSKQKLSKIKYDCVFGSPPWGGPEYLRND 187
679************************************************************************************** PP
Methyltransf_15 91 kfdlekkleplklekllkesvklskniilfLPrnsdlkqlaaltaevlenaskvkvvklkenglvkallaylge 164
++dle++l+p+ ++k+lk+++kls n+i+fLPrnsdl+ql++ t++vl++ +k+kv+++keng++k++++++ge
sp|Q12052|TGS1_YEAST 188 VYDLEQHLKPMGITKMLKSFLKLSPNVIMFLPRNSDLNQLSRATRKVLGPFAKCKVLYVKENGYMKGIFCMWGE 261
************************************************************************97 PP
>> sp|P25087|ERG6_YEAST Sterol 24-C-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=55929
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 27.6 0.5 6.9e-10 7e-07 3 61 .. 122 181 .. 120 210 .. 0.87
Alignments for each domain:
== domain 1 score: 27.6 bits; conditional E-value: 6.9e-10
Methyltransf_15 3 vvlDlfgGaGGnviqfanv.fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfel 61
+vlD+ +G GG + ++a+ ++vi+++ n ++++ a+ a+ Y+ sd++++v+gd++++
sp|P25087|ERG6_YEAST 122 LVLDVGCGVGGPAREIARFtGCNVIGLNNNDYQIAKAKYYAKKYNLSDQMDFVKGDFMKM 181
69***************98789***********************************983 PP
>> sp|P33753|TRM2_YEAST tRNA (uracil(54)-C(5))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 21.7 0.1 4.3e-08 4.3e-05 3 83 .. 491 569 .. 489 598 .. 0.89
Alignments for each domain:
== domain 1 score: 21.7 bits; conditional E-value: 4.3e-08
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwGG 83
++D+++G+G +i + +kvi+++i+ + + a++Na++ gv+ + +++g+ ++l++++ + + ++ v+l pP G
sp|P33753|TRM2_YEAST 491 FLVDAYCGSGLFSICSSKGVDKVIGVEISADSVSFAEKNAKANGVE-NCRFIVGKAEKLFESIDTPSENT-SVILDPPRKG 569
689****************************************996.689************99998855.5566777655 PP
>> sp|P11709|BIK1_YEAST Nuclear fusion protein BIK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 5.5 0.1 0.0042 4.2 86 154 .. 144 213 .. 140 219 .. 0.88
2 ! 9.2 0.1 0.00032 0.32 99 153 .. 337 392 .. 320 402 .. 0.78
Alignments for each domain:
== domain 1 score: 5.5 bits; conditional E-value: 0.0042
Methyltransf_15 86 Ykkkekfdlekkleplklekllkesvklsknii.lfLPrnsdlkqlaaltaevlenaskvkvvklkengl 154
+++++f +++ + ++++ +l+++ k +n + P n +++l++ + +++++++ kl+ + l
sp|P11709|BIK1_YEAST 144 HHQQQEFGYDNREDRMEVDSILSSDRKANHNTTsDWKPDNGHMNDLNSSEVTIELREAQLTIEKLQRKQL 213
578999***99***************9999998689***********99999999999999998887765 PP
== domain 2 score: 9.2 bits; conditional E-value: 0.00032
Methyltransf_15 99 eplklekllkesvklskniilfLPrnsdlkqlaaltaevlenaskvkvvk.lkeng 153
+++ + l ke +lsk++ l P++s +++a+lt+++ e ++k+k ++ ++ +
sp|P11709|BIK1_YEAST 337 LKMHNDSLSKEYQNLSKELFLTKPQDSSSEEVASLTKKLEEANEKIKQLEqAQAQT 392
45667788899999********************************8654044444 PP
>> sp|P38892|CRG1_YEAST Probable S-adenosylmethionine-dependent methyltransferase CRG1 OS=Saccharomyces cerevisiae (str
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.1 0.0 3.9e-05 0.039 3 56 .. 41 94 .. 39 117 .. 0.85
Alignments for each domain:
== domain 1 score: 12.1 bits; conditional E-value: 3.9e-05
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlg 56
++D+ +G+G + ++ +f++vi+id + l +a++ ++ ++k+ ++ +
sp|P38892|CRG1_YEAST 41 SLVDIGCGTGKATFVVEPYFKEVIGIDPSSAMLSIAEKETNERRLDKKIRFINA 94
689***********************************9999999999999976 PP
>> sp|P53972|RCM1_YEAST 25S rRNA (cytosine(2278)-C(5))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 20450
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.6 0.0 5.7e-05 0.058 3 81 .. 245 330 .. 243 350 .. 0.79
Alignments for each domain:
== domain 1 score: 11.6 bits; conditional E-value: 5.7e-05
Methyltransf_15 3 vvlDlfgGaGGnviqfanv.........fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPw 81
+v+D ++ G ++ + a + ++++a +++++r k+ q+ ++ g s ++ + +gd+++l + k + + + ++ p
sp|P53972|RCM1_YEAST 245 IVIDSCSAPGNKTTHTASYiypeppkdnNTRIYAFEKDPERAKVLQKMIKIAGCSPNISVNVGDFTKLATPEKYKDV--TCFIVDPSC 330
5677777777777777776666666666679************************************9999888887..555555554 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (165 nodes)
Target sequences: 6049 (2936363 residues searched)
Passed MSV filter: 220 (0.0363696); expected 121.0 (0.02)
Passed bias filter: 145 (0.0239709); expected 121.0 (0.02)
Passed Vit filter: 17 (0.00281038); expected 6.0 (0.001)
Passed Fwd filter: 6 (0.000991899); expected 0.1 (1e-05)
Initial search space (Z): 6049 [actual number of targets]
Domain search space (domZ): 6 [number of targets reported over threshold]
# CPU time: 0.06u 0.00s 00:00:00.06 Elapsed: 00:00:00.03
# Mc/sec: 16150.00
//
[ok]