# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_15.hmm.txt
# target sequence database: proteomes/Tetrahymena_thermophila.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_15 [M=165]
Accession: PF09445.9
Description: RNA cap guanine-N2 methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
7.5e-13 49.1 1.0 7.5e-13 49.1 1.0 2.5 3 tr|I7MGH3|I7MGH3_TETTS RNA cap guanine-N2 methyltransferase
2.5e-11 44.2 6.4 2e-10 41.2 6.4 2.7 1 tr|Q22MG6|Q22MG6_TETTS RNA cap guanine-N2 methyltransferase
4.2e-11 43.4 3.5 4.2e-11 43.4 3.5 2.7 2 tr|I7MGF8|I7MGF8_TETTS RNA cap guanine-N2 methyltransferase
1.4e-05 25.5 0.6 4.5e-05 23.8 0.0 2.0 2 tr|Q245D9|Q245D9_TETTS UbiE/COQ5 family methyltransferase OS
0.00021 21.6 0.2 0.00021 21.6 0.2 1.9 3 tr|Q22BT0|Q22BT0_TETTS RNA cap guanine-N2 methyltransferase
0.00039 20.7 0.1 0.00093 19.5 0.0 1.7 2 tr|I7M0Y7|I7M0Y7_TETTS Embryo-abundant protein, putative OS=
0.001 19.4 0.1 0.002 18.4 0.1 1.5 1 tr|I7M9J8|I7M9J8_TETTS NOL1/NOP2/Sun family protein OS=Tetra
0.0024 18.2 0.1 0.0054 17.0 0.1 1.6 1 tr|W7XD08|W7XD08_TETTS tRNA (guanine(37)-N1)-methyltransfera
------ inclusion threshold ------
0.023 15.0 0.3 0.049 13.9 0.3 1.5 1 tr|I7M1S8|I7M1S8_TETTS tRNA (Uracil-5)-methyltransferase OS=
Domain annotation for each sequence (and alignments):
>> tr|I7MGH3|I7MGH3_TETTS RNA cap guanine-N2 methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=T
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.4 0.4 3.4 1e+04 44 60 .. 50 64 .. 31 110 .. 0.56
2 ? -3.6 0.1 4.1 1.2e+04 18 46 .. 142 170 .. 139 186 .. 0.70
3 ! 49.1 1.0 2.5e-16 7.5e-13 3 163 .. 322 489 .. 320 493 .. 0.79
Alignments for each domain:
== domain 1 score: -3.4 bits; conditional E-value: 3.4
Methyltransf_15 44 vYgvsdkvtlvlgdvfe 60
Y +++t+ + d+++
tr|I7MGH3|I7MGH3_TETTS 50 HY--TNNLTVTKTDIQN 64
44..4444444444444 PP
== domain 2 score: -3.6 bits; conditional E-value: 4.1
Methyltransf_15 18 fanvfekviaidinlsrlklaqhNaevYg 46
+a + +k+ia+ + s+l+ q+ e +
tr|I7MGH3|I7MGH3_TETTS 142 VATEKDKTIACSLDASNLEHFQKIFEKKQ 170
56666788888888888887777555544 PP
== domain 3 score: 49.1 bits; conditional E-value: 2.5e-16
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgv.sdkvtlvlgdvfellaklkleeikvdlvflSpPwGGpsYkk 88
+++D+++G GGn++qf ++ + v+a+d + + +k +++N + ++v+++++d+ +l + +l++++ d+vf+ p + +s +
tr|I7MGH3|I7MGH3_TETTS 322 ILIDACCGIGGNTVQFSKINKFVFAVDQSYRAIKTCNENIKNHKQdVSNVEFIQADFLSL-ECGELGQLRADIVFINPQIDMIS--E 405
68*****************999*******************99775689********985.566999999********998776..6 PP
Methyltransf_15 89 kekfdlekkleplklekllkesvklskniilfLPrnsdlkql...........aalta.evlenaskvkvvklkenglvkallaylg 163
++k d+ k+ + +l k +k++ ++skni + LP d++q+ +++ + + ++ +++++++ ng +k++l++lg
tr|I7MGH3|I7MGH3_TETTS 406 TTKPDIFKH-SSPNLLKAMKNAYRMSKNIAILLPYYIDINQIpilldkfyriyRNFPLdMIQHHCPHIEIIY--MNGKIKYFLILLG 489
777889555.555788899***********************777766655552222202333444444444..4677777777665 PP
>> tr|Q22MG6|Q22MG6_TETTS RNA cap guanine-N2 methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=T
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 41.2 6.4 6.8e-14 2e-10 2 146 .. 380 523 .. 379 604 .. 0.76
Alignments for each domain:
== domain 1 score: 41.2 bits; conditional E-value: 6.8e-14
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwGGp.... 84
++v+D+f+G G n++qfa++ ++viaid n+ ++ a+ N e + ++kv++++ d+ ++ +klk d v+l p
tr|Q22MG6|Q22MG6_TETTS 380 QIVVDAFCGVGYNTVQFAKEASQVIAIDCNQVKVSHAKYNIESFKQQHKVEVIQSDFLQM-KKLKA-----DTVVLHPDYKKFdnsi 460
689*****************************************************9874.34444.....4444444332220000 PP
Methyltransf_15 85 ..sYkkkekfdlekkleplklekllkesvklskniilfLPrnsdlkqlaaltaevlenaskvkv 146
s +++ +l ++++p l + lk s+k+s+ +++ L ++ d++ql +++ + + +k +v
tr|Q22MG6|Q22MG6_TETTS 461 ssSQGIDNSINLLTEVQPN-LVEALKLSFKISDSVVIILQKSCDIQQLPQVLEQANYPYKKFAV 523
0012224555666677764.4456688*********************8887776666666543 PP
>> tr|I7MGF8|I7MGF8_TETTS RNA cap guanine-N2 methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=T
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 43.4 3.5 1.4e-14 4.2e-11 3 164 .. 345 527 .. 343 528 .. 0.81
2 ? -1.2 0.4 0.72 2.2e+03 28 52 .. 542 566 .. 534 596 .. 0.70
Alignments for each domain:
== domain 1 score: 43.4 bits; conditional E-value: 1.4e-14
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe................llaklkleeikvd 73
++D+ + G +i+f n+ ++viai++++ r + a +Na +Y+v + ++ d +e l +++++++ d
tr|I7MGF8|I7MGF8_TETTS 345 SIVDVSCAVGQFSIAFSNQINQVIAIEKDPIRYQFARNNASIYNV----QNCKYDQNErmsfnegvlfyqdtsfLEEQFQTNANLSD 427
689****************************************66....44444444455567899999***9888889999999** PP
Methyltransf_15 74 lvflSpPwGGpsYkkkekfdlekklepl...klekllkesvklskniilfLPrnsdlkqlaalta.evlenaskvk.....vvklke 151
+vf+ p + +k +++d + + + +l lk+++k+ ++ilf Prn+++ ++ +l + + en +kvk + k
tr|I7MGF8|I7MGF8_TETTS 428 IVFIAPHLLSENINKIQNYDDPYFQSSYfydSLRLYLKKAFKIAPQVILFTPRNVKIIDIVDLFTdAIKENLNKVKkcsieIEKHFV 514
********************6443333311145555788*********************887551567777777766666778888 PP
Methyltransf_15 152 nglvkallaylge 164
n +k+++ y+ge
tr|I7MGF8|I7MGF8_TETTS 515 NDHLKYICFYFGE 527
9999******996 PP
== domain 2 score: -1.2 bits; conditional E-value: 0.72
Methyltransf_15 28 idinlsrlklaqhNaevYgvsdkvt 52
i+ +l++++ +++N + Y+ + ++
tr|I7MGF8|I7MGF8_TETTS 542 INQQLEKCYTINNNKQKYQKQTSIQ 566
7788899999999999997766664 PP
>> tr|Q245D9|Q245D9_TETTS UbiE/COQ5 family methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTH
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 23.8 0.0 1.5e-08 4.5e-05 3 75 .. 53 127 .. 51 132 .. 0.93
2 ? -0.7 0.2 0.5 1.5e+03 82 101 .. 205 224 .. 161 254 .. 0.75
Alignments for each domain:
== domain 1 score: 23.8 bits; conditional E-value: 1.5e-08
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei..kvdlv 75
+lD+ +G+G q++n fek i+ di++++l ++++ + + s+ v +++d+ +l + l+++++ k+dl+
tr|Q245D9|Q245D9_TETTS 53 AYLDIACGTGQLLFQLQNHFEKSIGTDISEKQLSVVEELIKSNNLSNSVYSIKADCHQLPNILQEKNLptKFDLI 127
79********************************************************99999988876678877 PP
== domain 2 score: -0.7 bits; conditional E-value: 0.5
Methyltransf_15 82 GGpsYkkkekfdlekklepl 101
G p+Y+ +e + + kk+e++
tr|Q245D9|Q245D9_TETTS 205 GYPNYRFNEIYKFVKKIEQI 224
55777777777777766655 PP
>> tr|Q22BT0|Q22BT0_TETTS RNA cap guanine-N2 methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=T
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 21.6 0.2 7e-08 0.00021 3 75 .. 40 114 .. 38 118 .. 0.87
2 ? -3.3 0.0 3.2 9.5e+03 144 163 .. 134 153 .. 128 154 .. 0.78
3 ? -2.5 0.3 1.8 5.3e+03 87 130 .. 190 233 .. 187 267 .. 0.58
Alignments for each domain:
== domain 1 score: 21.6 bits; conditional E-value: 7e-08
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei..kvdlv 75
+lD+ +G+G +++ f+ ++ di+++++ +a++ + ++v+++++d ++++++l+++++ ++dlv
tr|Q22BT0|Q22BT0_TETTS 40 NYLDVGCGTGQMLFKLNSHFKFAVGTDISEKQVSVANEKIANNQEYSNVKVIQCDANNIISSLEKNSLplSYDLV 114
68*******************************99986544444449*****************99987788887 PP
== domain 2 score: -3.3 bits; conditional E-value: 3.2
Methyltransf_15 144 vkvvklkenglvkallaylg 163
k++k ++n++ + ++y++
tr|Q22BT0|Q22BT0_TETTS 134 SKILKQNQNSRFATAAYYWD 153
46788899999999999986 PP
== domain 3 score: -2.5 bits; conditional E-value: 1.8
Methyltransf_15 87 kkkekfdlekkleplklekllkesvklskniilfLPrnsdlkql 130
++ + + ++k e+++ + +++++ + ++ ++ +s + l
tr|Q22BT0|Q22BT0_TETTS 190 TNYKYYPFNKYFEQISEDSFVEKDIFQLDDLVRYMKTSSAYNTL 233
55555555555555555555555555555555555444444444 PP
>> tr|I7M0Y7|I7M0Y7_TETTS Embryo-abundant protein, putative OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHE
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 19.5 0.0 3.1e-07 0.00093 3 75 .. 43 117 .. 41 130 .. 0.89
2 ? -2.3 0.0 1.6 4.7e+03 54 69 .. 217 232 .. 200 270 .. 0.68
Alignments for each domain:
== domain 1 score: 19.5 bits; conditional E-value: 3.1e-07
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei..kvdlv 75
++D+ +G+G ++ n f+ + di++++++++++ + + +d+v+ +++d +l + +++ + k+dl+
tr|I7M0Y7|I7M0Y7_TETTS 43 NFVDIACGTGQLLFELSNHFKFSLGTDISPKQIEVTNQKIQKKNLQDRVKAIVCDAHSLSKISTEQGLpsKYDLI 117
579****************************************************99987766666555566666 PP
== domain 2 score: -2.3 bits; conditional E-value: 1.6
Methyltransf_15 54 vlgdvfellaklklee 69
+ +fe+++ lk+ +
tr|I7M0Y7|I7M0Y7_TETTS 217 TPCSIFEMVKYLKTYS 232
4555555555544433 PP
>> tr|I7M9J8|I7M9J8_TETTS NOL1/NOP2/Sun family protein OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHERM_00
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.4 0.1 6.7e-07 0.002 3 115 .. 214 325 .. 212 363 .. 0.79
Alignments for each domain:
== domain 1 score: 18.4 bits; conditional E-value: 6.7e-07
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei.kvdlvflSpPwGGpsYkk 88
vlD ++GaGG++ +fa + + + i +r ++ q+ + + + ++ v+ +e l++ k + + k+d v++ +P G +
tr|I7M9J8|I7M9J8_TETTS 214 HVLDYCAGAGGKSLAFAPYLKGTGQIYLHDTRDYILQEAKKRF-NKAGIQNVQFHTQESLNNNKNKLVkKFDWVVCDVPCTGTGTLR 299
58*****************999999999999988888888888.577899999999999999988888789***********98776 PP
Methyltransf_15 89 kekfdlekkleplklekllkesvklsk 115
++ dl++k + l+ ++ + ++ k
tr|I7M9J8|I7M9J8_TETTS 300 RN-PDLKYKFSRNRLKYFVDLQASVFK 325
65.477777777777666666555555 PP
>> tr|W7XD08|W7XD08_TETTS tRNA (guanine(37)-N1)-methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 G
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.0 0.1 1.8e-06 0.0054 2 61 .. 225 293 .. 224 327 .. 0.79
Alignments for each domain:
== domain 1 score: 17.0 bits; conditional E-value: 1.8e-06
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe.........l 61
e+vlDlf+G G +i a++ +kvi+ d n++ N e +v+dk + d +
tr|W7XD08|W7XD08_TETTS 225 ETVLDLFCGVGPLAIRAAKMGCKVICNDLNPHCYDYLLINREKNNVEDKTLCFNNDARKvvdilvskeE 293
579*****************************999**************99999999884444333332 PP
>> tr|I7M1S8|I7M1S8_TETTS tRNA (Uracil-5)-methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 GN=TTHE
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.9 0.3 1.6e-05 0.049 2 62 .. 533 592 .. 532 636 .. 0.82
Alignments for each domain:
== domain 1 score: 13.9 bits; conditional E-value: 1.6e-05
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfell 62
+++lD+++G G i +an+ ++vi+i++ ++ ++ a+ N e g+ + ++++ +v++++
tr|I7M1S8|I7M1S8_TETTS 533 TIFLDICSGIGTIGICLANSAKEVIGIEMVETACNDAKINIEQNGITN-YKVICSKVEDVI 592
589***************************************999854.344555555444 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (165 nodes)
Target sequences: 26971 (16912921 residues searched)
Passed MSV filter: 3169 (0.117497); expected 539.4 (0.02)
Passed bias filter: 388 (0.0143858); expected 539.4 (0.02)
Passed Vit filter: 30 (0.00111231); expected 27.0 (0.001)
Passed Fwd filter: 9 (0.000333692); expected 0.3 (1e-05)
Initial search space (Z): 26971 [actual number of targets]
Domain search space (domZ): 9 [number of targets reported over threshold]
# CPU time: 0.26u 0.01s 00:00:00.27 Elapsed: 00:00:00.10
# Mc/sec: 27906.32
//
[ok]