# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_15.hmm.txt
# target sequence database: proteomes/Thermococcus_kodakarensis.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_15 [M=165]
Accession: PF09445.9
Description: RNA cap guanine-N2 methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
3.5e-10 36.9 0.0 5.9e-10 36.2 0.0 1.4 1 tr|Q5JJ78|Q5JJ78_THEKO Probable tRNA/rRNA methyltransferase
9.9e-08 29.0 0.0 1.7e-07 28.2 0.0 1.3 1 tr|Q5JEM0|Q5JEM0_THEKO Predicted N6-adenine-specific DNA met
1.1e-07 28.8 0.0 1.8e-07 28.1 0.0 1.3 1 tr|Q5JID5|Q5JID5_THEKO N2, N2-dimethylguanosine tRNA methylt
1.7e-07 28.2 0.0 2.6e-07 27.6 0.0 1.3 1 tr|Q5JH73|Q5JH73_THEKO Uncharacterized protein OS=Thermococc
5e-07 26.7 0.0 7.8e-07 26.0 0.0 1.3 1 tr|Q5JDR0|Q5JDR0_THEKO SAM-dependent methyltransferase, UPF0
1.8e-06 24.8 0.0 2.7e-06 24.3 0.0 1.3 1 tr|Q5JDP7|Q5JDP7_THEKO Predicted DNA methylase OS=Thermococc
2.3e-05 21.2 0.0 4.8e-05 20.2 0.0 1.5 1 tr|Q5JHF7|Q5JHF7_THEKO 23S rRNA (Uracil-5-)-methyltransferas
4.4e-05 20.4 0.0 6.7e-05 19.8 0.0 1.3 1 tr|Q5JD70|Q5JD70_THEKO Met-10+ like protein OS=Thermococcus
0.0012 15.7 0.0 0.0028 14.5 0.0 1.7 1 tr|Q5JE68|Q5JE68_THEKO 23S rRNA (Uracil-5-)-methyltransferas
0.0021 14.9 0.0 0.0038 14.1 0.0 1.4 1 tr|Q5JGN8|Q5JGN8_THEKO SAM-dependent methyltransferase, UbiE
0.0048 13.7 0.0 0.0073 13.1 0.0 1.4 1 tr|Q5JEC3|Q5JEC3_THEKO Predicted DNA methylase OS=Thermococc
0.0054 13.5 0.0 0.0074 13.1 0.0 1.3 1 tr|Q5JEW7|Q5JEW7_THEKO tRNA/rRNA cytosine-C5-methylase, NOL1
0.0058 13.4 0.0 0.011 12.6 0.0 1.3 1 tr|Q5JIX8|Q5JIX8_THEKO N5-glutamine methyltransferase, HemK
------ inclusion threshold ------
0.012 12.4 0.0 0.015 12.1 0.0 1.3 1 tr|Q5JHQ2|Q5JHQ2_THEKO SAM-dependent methyltransferase, UbiE
0.013 12.3 0.0 0.019 11.7 0.0 1.3 1 tr|Q5JEI4|Q5JEI4_THEKO tRNA(Phe) (4-demethylwyosine(37)-C(7)
0.022 11.6 0.0 0.04 10.7 0.0 1.5 1 tr|Q5JDB4|Q5JDB4_THEKO tRNA/rRNA cytosine-C5-methylase, NOL1
Domain annotation for each sequence (and alignments):
>> tr|Q5JJ78|Q5JJ78_THEKO Probable tRNA/rRNA methyltransferase OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 36.2 0.0 4.1e-12 5.9e-10 3 81 .. 220 299 .. 218 336 .. 0.95
Alignments for each domain:
== domain 1 score: 36.2 bits; conditional E-value: 4.1e-12
Methyltransf_15 3 vvlDlfgGaGGnviqfanv.fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPw 81
vlD+f+ +GG +i+ a ++v+a+d+++ ++++++Na++ gv+dk+++++g f +++++ ++ k+d+v+l pP
tr|Q5JJ78|Q5JJ78_THEKO 220 RVLDVFTYTGGFAIHAAVAgADEVVAVDKSPWAINMVKENAKLNGVEDKMKYIVGSAFPVMEEMIKRGEKFDIVILDPPA 299
58***************996789****************************************9999999********95 PP
>> tr|Q5JEM0|Q5JEM0_THEKO Predicted N6-adenine-specific DNA methylase OS=Thermococcus kodakarensis (strain ATCC BAA-918
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 28.2 0.0 1.2e-09 1.7e-07 4 65 .. 221 284 .. 219 304 .. 0.86
Alignments for each domain:
== domain 1 score: 28.2 bits; conditional E-value: 1.2e-09
Methyltransf_15 4 vlDlfgGaGGnviqfanv..fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellakl 65
++D+f+G+G i++a+ ++i++++ +++++ a+ Na gv dk+++++gd ++l + +
tr|Q5JEM0|Q5JEM0_THEKO 221 FIDPFCGSGTILIELALRgyKGRIIGLEKYRKHIRGAEMNALSAGVLDKIEFIQGDATKLSQYV 284
69**************9964358*********************************99876654 PP
>> tr|Q5JID5|Q5JID5_THEKO N2, N2-dimethylguanosine tRNA methyltransferase OS=Thermococcus kodakarensis (strain ATCC BAA
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 28.1 0.0 1.3e-09 1.8e-07 3 82 .. 182 258 .. 180 272 .. 0.89
Alignments for each domain:
== domain 1 score: 28.1 bits; conditional E-value: 1.3e-09
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwG 82
+lD+f GaGG i+ + +v+++di ++ ++ a+ N + Ygv d tl+lgd + l + ++ + v + pP G
tr|Q5JID5|Q5JID5_THEKO 182 EILDPFMGAGGILIEAGLLGLRVYGVDIRPEMVEGAETNLKHYGVRDY-TLKLGDATRLEDLFPDKKF--EAVATDPPYG 258
69*******************************************885.8999999998777777766..8888888888 PP
>> tr|Q5JH73|Q5JH73_THEKO Uncharacterized protein OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 27.6 0.0 1.8e-09 2.6e-07 3 76 .. 86 155 .. 84 208 .. 0.79
Alignments for each domain:
== domain 1 score: 27.6 bits; conditional E-value: 1.8e-09
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvf 76
+ D+ +G G + i +a+ e+ ++idi++ +++ a +Nae Ygvs +++++ +d + + e++ ++vf
tr|Q5JH73|Q5JH73_THEKO 86 SIADVSCGIGIQLIFYAMKVERAYGIDIDPLKIEFARRNAEKYGVS-NIEFINADSLSPETV---ERVDAEVVF 155
578****************************************996.79****998764333...233233444 PP
>> tr|Q5JDR0|Q5JDR0_THEKO SAM-dependent methyltransferase, UPF0020 family OS=Thermococcus kodakarensis (strain ATCC BAA
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 26.0 0.0 5.4e-09 7.8e-07 2 81 .. 129 208 .. 128 229 .. 0.90
Alignments for each domain:
== domain 1 score: 26.0 bits; conditional E-value: 5.4e-09
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgv..sdkvtlvlgdvfellaklkleeikvdlvflSpPw 81
e+vlD + G G +i+ + vi+i+++++ +++a N + k+++++gd fe+++k+k+++ d+++ pP
tr|Q5JDR0|Q5JDR0_THEKO 129 ETVLDTCMGLGYTAIEASKRGAYVITIEKDPNVIEIARINPWSRELftGGKIQVIQGDAFEVVKKFKQASF--DVIIHDPPR 208
579************************************97655543389****************99999..******995 PP
>> tr|Q5JDP7|Q5JDP7_THEKO Predicted DNA methylase OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 24.3 0.0 1.9e-08 2.7e-06 4 83 .. 51 124 .. 48 159 .. 0.78
Alignments for each domain:
== domain 1 score: 24.3 bits; conditional E-value: 1.9e-08
Methyltransf_15 4 vlDlfgGaGGnviqfanv.fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvdlvflSpPwGG 83
+ Dl +G+G i + e+v+a++ +++ l++a +Na+ gv+dk+++v +dv e +vd v++ pP G
tr|Q5JDP7|Q5JDP7_THEKO 51 IADLGAGTGVLGIGAVLLgAENVYAVERDKEALEIARENARSLGVEDKIEFVNADVSEFSV-------NVDTVIMNPPFGS 124
5566666665555555444689*********************************988533.......3467777777774 PP
>> tr|Q5JHF7|Q5JHF7_THEKO 23S rRNA (Uracil-5-)-methyltransferase OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JC
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 20.2 0.0 3.3e-07 4.8e-05 3 51 .. 280 328 .. 278 358 .. 0.83
Alignments for each domain:
== domain 1 score: 20.2 bits; conditional E-value: 3.3e-07
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkv 51
vlDl++G G i +a+ kv +i+in+ +++a++Na++ gv+ +
tr|Q5JHF7|Q5JHF7_THEKO 280 KVLDLYSGVGTFGIYLAKRGFKVEGIEINPFAVEMAKKNAQINGVDAEF 328
69*****************88**********************998754 PP
>> tr|Q5JD70|Q5JD70_THEKO Met-10+ like protein OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) OX
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 19.8 0.0 4.7e-07 6.7e-05 2 71 .. 183 251 .. 182 275 .. 0.90
Alignments for each domain:
== domain 1 score: 19.8 bits; conditional E-value: 4.7e-07
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeik 71
e+v D+f+G G +i +a+ + v+a+din+ ++ ++N ++ +v +lgdv ++ ++k +++
tr|Q5JD70|Q5JD70_THEKO 183 EIVFDMFAGVGPYSILLAKKAKLVFACDINPWAVRYLEENKKLN-KTPNVIPILGDVRKVAGQIKADRVI 251
5899*************************************997.7899*********988888777664 PP
>> tr|Q5JE68|Q5JE68_THEKO 23S rRNA (Uracil-5-)-methyltransferase OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JC
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.5 0.0 1.9e-05 0.0028 2 55 .. 283 334 .. 282 377 .. 0.80
Alignments for each domain:
== domain 1 score: 14.5 bits; conditional E-value: 1.9e-05
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvl 55
e++lDl++G G + +a+ +v +i+ n+ +++a++Nae+ +v+ t+++
tr|Q5JE68|Q5JE68_THEKO 283 EMILDLYAGVGTFGVWLAKRRFQVEGIELNPFAVEIANKNAEINNVDA--TFKV 334
589***************9966*********************97765..3444 PP
>> tr|Q5JGN8|Q5JGN8_THEKO SAM-dependent methyltransferase, UbiE/COQ5 family OS=Thermococcus kodakarensis (strain ATCC B
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.1 0.0 2.6e-05 0.0038 2 68 .. 43 107 .. 42 135 .. 0.84
Alignments for each domain:
== domain 1 score: 14.1 bits; conditional E-value: 2.6e-05
Methyltransf_15 2 evvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkle 68
+ vlDl +G+G + ++a+ +v ++d ++ l++a + ae+ g +v+++ g+ ++ + +++
tr|Q5JGN8|Q5JGN8_THEKO 43 KRVLDLACGTGIPTLELAERGYEVLGLDLHEEMLRVARRKAEARGL--NVKFIRGNALDISFEEEFD 107
579*****************99*********************955..7889999888755444444 PP
>> tr|Q5JEC3|Q5JEC3_THEKO Predicted DNA methylase OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 13.1 0.0 5.1e-05 0.0073 4 78 .. 194 269 .. 191 334 .. 0.78
Alignments for each domain:
== domain 1 score: 13.1 bits; conditional E-value: 5.1e-05
Methyltransf_15 4 vlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleei...kvdlvflS 78
+lD+f+G G v +f ++ + ++ d ++ +++ a++N ++ l+ e+ kl+++ ++d +++
tr|Q5JEC3|Q5JEC3_THEKO 194 FLDPFCGIGTVVQEFVLQGLTAYGSDRDEGQIRDAKKNLTWL--RKEFRLKNSAHLEVCDARKLKKCfrqRFDAIVTE 269
79************************************9765..4444444444444333333333333334555555 PP
>> tr|Q5JEW7|Q5JEW7_THEKO tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, containing RNA-binding PUA domain OS=T
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 13.1 0.0 5.2e-05 0.0074 3 60 .. 201 260 .. 199 347 .. 0.84
Alignments for each domain:
== domain 1 score: 13.1 bits; conditional E-value: 5.2e-05
Methyltransf_15 3 vvlDlfgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe 60
+++D+ + GG++ ++a+ ++iaid++++rl+ +++ + gv ++v l++ d +
tr|Q5JEW7|Q5JEW7_THEKO 201 LIIDMAAAPGGKTSHIAQLmqnRGEIIAIDKSRNRLRKMEEELKRLGV-KNVRLIHMDARK 260
689************9999443337*********************98.579999998876 PP
>> tr|Q5JIX8|Q5JIX8_THEKO N5-glutamine methyltransferase, HemK family OS=Thermococcus kodakarensis (strain ATCC BAA-918
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 12.6 0.0 7.3e-05 0.011 3 63 .. 37 96 .. 35 108 .. 0.87
Alignments for each domain:
== domain 1 score: 12.6 bits; conditional E-value: 7.3e-05
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfella 63
+ lD+ +G+G + +a+ + v ++din+ ++la +Na++ g+ +v++ l d+fe ++
tr|Q5JIX8|Q5JIX8_THEKO 37 IALDMGTGTGIIALLLARKARWVLGVDINPLAVELARENARINGII-NVEFRLSDLFENVS 96
6799999999999999999888*********************985.79999999999876 PP
>> tr|Q5JHQ2|Q5JHQ2_THEKO SAM-dependent methyltransferase, UbiE/COQ5 family OS=Thermococcus kodakarensis (strain ATCC B
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.1 0.0 0.0001 0.015 3 61 .. 41 103 .. 39 184 .. 0.84
Alignments for each domain:
== domain 1 score: 12.1 bits; conditional E-value: 0.0001
Methyltransf_15 3 vvlDlfgGaGGnviqfanvfekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfe......l 61
vlDl +G GG + ++ +v+++d ++ l+ a + a+ +++v+++ gd e
tr|Q5JHQ2|Q5JHQ2_THEKO 41 RVLDLACGVGGFSFLLEDLGFEVVGLDNSRFMLEKAREFAKEK--ESRVEFIEGDARElpfendS 103
68****************988*******************988..9*********9885544440 PP
>> tr|Q5JEI4|Q5JEI4_THEKO tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase OS=Thermococcus kodakare
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.7 0.0 0.00014 0.019 3 58 .. 128 184 .. 126 220 .. 0.87
Alignments for each domain:
== domain 1 score: 11.7 bits; conditional E-value: 0.00014
Methyltransf_15 3 vvlDlfgGaGGnviqfanv.fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdv 58
+v+D+f+G G + + +viai++++++ + +N + gv+d +t d
tr|Q5JEI4|Q5JEI4_THEKO 128 LVVDMFAGIGHLSLPMTVHkGARVIAIEKDPYTFRFLVENIWLNGVQDLMTPYNMDN 184
799***********99977699************************99998877665 PP
>> tr|Q5JDB4|Q5JDB4_THEKO tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, fused to N-terminal NusB regulator dom
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.7 0.0 0.00028 0.04 4 73 .. 265 336 .. 262 375 .. 0.80
Alignments for each domain:
== domain 1 score: 10.7 bits; conditional E-value: 0.00028
Methyltransf_15 4 vlDlfgGaGGnviqfanv...fekviaidinlsrlklaqhNaevYgvsdkvtlvlgdvfellaklkleeikvd 73
+lDl + G ++ + a +++a+d++ +rl +++ a+v gv ++v +v++d ++ k k+++i d
tr|Q5JDB4|Q5JDB4_THEKO 265 LLDLAAAPGSKTFHAAALmenKGEIVAVDYSYDRLMRMKEKAKVLGV-KNVRFVHADGQSFRDKEKFDKIILD 336
788888888888876666333338*********************99.58*******9998888888887554 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (165 nodes)
Target sequences: 2301 (637680 residues searched)
Passed MSV filter: 72 (0.0312907); expected 46.0 (0.02)
Passed bias filter: 69 (0.029987); expected 46.0 (0.02)
Passed Vit filter: 26 (0.0112994); expected 2.3 (0.001)
Passed Fwd filter: 16 (0.0069535); expected 0.0 (1e-05)
Initial search space (Z): 2301 [actual number of targets]
Domain search space (domZ): 16 [number of targets reported over threshold]
# CPU time: 0.03u 0.00s 00:00:00.03 Elapsed: 00:00:00.02
# Mc/sec: 5260.86
//
[ok]