# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_4.hmm.txt
# target sequence database: proteomes/Ciona_intestinalis.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_4 [M=173]
Accession: PF02390.16
Description: Putative methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
3.2e-57 192.7 0.0 4e-57 192.3 0.0 1.1 1 tr|H2XYT3|H2XYT3_CIOIN tRNA (guanine-N(7)-)-methyltransferas
2.9e-06 26.8 1.2 2.3e-05 23.9 0.1 2.2 2 tr|F6TIA8|F6TIA8_CIOIN Uncharacterized protein OS=Ciona inte
0.00028 20.3 0.0 0.00059 19.3 0.0 1.6 2 tr|H2XK62|H2XK62_CIOIN Histone-lysine N-methyltransferase, H
0.0022 17.4 0.1 0.0027 17.1 0.1 1.1 1 tr|L7N0T2|L7N0T2_CIOIN Uncharacterized protein OS=Ciona inte
0.0054 16.1 0.0 0.14 11.5 0.0 2.4 2 tr|F6ZXR3|F6ZXR3_CIOIN Uncharacterized protein OS=Ciona inte
0.0076 15.6 0.2 0.017 14.5 0.2 1.6 1 tr|F6UUI8|F6UUI8_CIOIN Uncharacterized protein OS=Ciona inte
------ inclusion threshold ------
0.014 14.7 0.0 0.036 13.4 0.0 1.7 2 tr|F6ZLL7|F6ZLL7_CIOIN Protein-lysine N-methyltransferase OS
0.026 13.9 0.0 0.045 13.1 0.0 1.3 1 tr|F6WB92|F6WB92_CIOIN methyltransferase-like protein 5 isof
0.028 13.8 0.0 6.1 6.2 0.0 2.5 2 tr|F6VYQ8|F6VYQ8_CIOIN uncharacterized protein LOC100177375
0.081 12.3 0.2 0.12 11.7 0.2 1.4 1 tr|F6TU78|F6TU78_CIOIN Uncharacterized protein OS=Ciona inte
Domain annotation for each sequence (and alignments):
>> tr|H2XYT3|H2XYT3_CIOIN tRNA (guanine-N(7)-)-methyltransferase OS=Ciona intestinalis OX=7719 GN=LOC100180383 PE=3 SV=
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 192.3 0.0 2.4e-60 4e-57 2 172 .. 71 249 .. 70 250 .. 0.98
Alignments for each domain:
== domain 1 score: 192.3 bits; conditional E-value: 2.4e-60
-EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC........TTSSEEEEES-CCCHHHHCS-TTSEEEEEEES CS
Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal........elkNlrilrgdalkvllelledgslekifilF 80
++ vl+iGcG+G++l+al+k Pd+++ G+Eirvkv+++v ++i+al e++N++++r++a+k+l++++++g+l+k filF
tr|H2XYT3|H2XYT3_CIOIN 71 KVEVLDIGCGYGGLLIALSKLLPDTLITGMEIRVKVSDYVQERIQALrmahvgtkEFQNVACIRTNAMKYLPNFFSKGQLKKTFILF 157
5789*********************************************************************************** PP
-----SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTTEEESSCCCSCCTCHCHHCCCSSTTCCCCCCTT CS
Methyltransf_4 81 PDPwfKkrhhKrRllqpellkelarvLkkgGvlelaTDveeyaeemlkvleeeplferlskeeeleeeplsvlriatkyeqkvqskg 167
PDP+fKk++hK+R+++++ll+e+a++L +gG+l+++TDv e++e+m+k+++e+plf r++++e + + + + + ++t++++kv +++
tr|H2XYT3|H2XYT3_CIOIN 158 PDPHFKKQKHKWRIVSSTLLAEYAYILCQGGLLYTITDVLEVHEWMVKHFSEHPLFDRVDDHELKDDACYKAMFVSTEEGKKVARNN 244
*************************************************************************************** PP
SS-EE CS
Methyltransf_4 168 keiye 172
+e+y
tr|H2XYT3|H2XYT3_CIOIN 245 GEKYP 249
99986 PP
>> tr|F6TIA8|F6TIA8_CIOIN Uncharacterized protein OS=Ciona intestinalis OX=7719 PE=4 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 1.3 0.1 0.11 1.9e+02 83 119 .. 144 179 .. 128 205 .. 0.73
2 ! 23.9 0.1 1.4e-08 2.3e-05 4 66 .. 334 395 .. 331 401 .. 0.91
Alignments for each domain:
== domain 1 score: 1.3 bits; conditional E-value: 0.11
---SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEEESH CS
Methyltransf_4 83 PwfKkrhhKrRllqpellkelarvLkkgGvlelaTDv 119
P +Kk ++Kr +++ + l +++v +g +l +++D+
tr|F6TIA8|F6TIA8_CIOIN 144 PPHKKMRTKRKVVNTKDLPPMEHVFAEGIEL-MVSDL 179
44566677**********9999999988776.45664 PP
== domain 2 score: 23.9 bits; conditional E-value: 1.4e-08
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHH CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvlle 66
v+++ ++G G++ + lA+ P ++++ +E +++++++++++i++l+lkN+ i + + +++ +
tr|F6TIA8|F6TIA8_CIOIN 334 VLVDFCSGGGHVGIVLAHLLPLCKIILVENKEESLERAMQRIQELNLKNIMIYQCNL-DQFMK 395
789****************************************************96.55444 PP
>> tr|H2XK62|H2XK62_CIOIN Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Ciona intestinalis OX=7719 PE=3
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.4 0.0 3.3 5.5e+03 136 158 .. 55 77 .. 43 89 .. 0.50
2 ! 19.3 0.0 3.5e-07 0.00059 3 34 .. 161 192 .. 159 207 .. 0.92
Alignments for each domain:
== domain 1 score: -3.4 bits; conditional E-value: 3.3
EEESSCCCSCCTCHCHHCCCSST CS
Methyltransf_4 136 ferlskeeeleeeplsvlriatk 158
+e++ +++ l++ ++ ++ + +
tr|H2XK62|H2XK62_CIOIN 55 LEMAMEKHILADYDTKNFESMKE 77
44444444444444433333333 PP
== domain 2 score: 19.3 bits; conditional E-value: 3.5e-07
EEEEEET-TTSHHHHHHHHHSTTSEEEEEES- CS
Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEir 34
v+l++G+G G+++++ A + P k++lGiE+
tr|H2XK62|H2XK62_CIOIN 161 DVFLDLGSGVGQVVLQVAAASPCKLCLGIEKA 192
689***************************75 PP
>> tr|L7N0T2|L7N0T2_CIOIN Uncharacterized protein OS=Ciona intestinalis OX=7719 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.1 0.1 1.6e-06 0.0027 3 52 .. 25 72 .. 23 78 .. 0.78
Alignments for each domain:
== domain 1 score: 17.1 bits; conditional E-value: 1.6e-06
EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSS CS
Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkN 52
+vvl++GcG G + + A k +++GiE + ++v+++ k +ea++l
tr|L7N0T2|L7N0T2_CIOIN 25 KVVLDVGCGTGVL-SMFAAKAGAAKVIGIECS-SIVDYAKKIVEANKLDH 72
799*******965.55666777789*****96.57899999888887765 PP
>> tr|F6ZXR3|F6ZXR3_CIOIN Uncharacterized protein OS=Ciona intestinalis OX=7719 PE=4 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 11.5 0.0 8.6e-05 0.14 5 62 .. 1 53 [. 1 66 [. 0.82
2 ? 2.4 0.0 0.051 85 97 115 .. 76 94 .. 73 163 .. 0.84
Alignments for each domain:
== domain 1 score: 11.5 bits; conditional E-value: 8.6e-05
EEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCC CS
Methyltransf_4 5 vleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalk 62
++e+GcG+G+++ + + n++Gi+i+ + ++++ +++ + N+ + gda k
tr|F6ZXR3|F6ZXR3_CIOIN 1 MVEVGCGSGQAIKKFVSYF--DNIIGIDISAEQIQEAE---QNNPFPNVSYAVGDAYK 53
58************99887..799*****998877765...56788888888888843 PP
== domain 2 score: 2.4 bits; conditional E-value: 0.051
HHHHHHHHHHEEEEEEEEE CS
Methyltransf_4 97 pellkelarvLkkgGvlel 115
+++l e+arvL+++G + +
tr|F6ZXR3|F6ZXR3_CIOIN 76 DKFLREVARVLRPQGCVAI 94
589999********99876 PP
>> tr|F6UUI8|F6UUI8_CIOIN Uncharacterized protein OS=Ciona intestinalis OX=7719 GN=LOC100182889 PE=3 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.5 0.2 1e-05 0.017 3 70 .. 428 493 .. 426 501 .. 0.89
Alignments for each domain:
== domain 1 score: 14.5 bits; conditional E-value: 1e-05
EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-T CS
Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelled 70
+l+++cG G++ ++l+ + ++G++i ++ + ++k++ ++++N + g a +vl++++e
tr|F6UUI8|F6UUI8_CIOIN 428 TALLDVCCGTGTIGLTLS--SCVNRLVGVDICEQAIIDAVKNATLNNITNAEFYVGKAEDVLPKAIES 493
5789*******9877776..577899*************************************99975 PP
>> tr|F6ZLL7|F6ZLL7_CIOIN Protein-lysine N-methyltransferase OS=Ciona intestinalis OX=7719 PE=3 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.4 0.0 2.2e-05 0.036 3 43 .. 66 105 .. 64 141 .. 0.83
2 ? -1.8 0.0 1 1.7e+03 120 147 .. 157 184 .. 155 194 .. 0.74
Alignments for each domain:
== domain 1 score: 13.4 bits; conditional E-value: 2.2e-05
EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHH CS
Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlk 43
+++l++GcG+G +l+alAk+ +n++G++ ++ ++ + +
tr|F6ZLL7|F6ZLL7_CIOIN 66 STILDVGCGNGLLLLALAKQG-YTNLVGLDYCQSALDLASA 105
689***************975.6788888887777766555 PP
== domain 2 score: -1.8 bits; conditional E-value: 1
HHHHHHHHHHHHCSTTEEESSCCCSCCT CS
Methyltransf_4 120 eeyaeemlkvleeeplferlskeeelee 147
e y ++m++ +++ f ++s ++ +e
tr|F6ZLL7|F6ZLL7_CIOIN 157 ESYIQNMATLMNCSSVFIITSCNWTTSE 184
5789999999999988877776655554 PP
>> tr|F6WB92|F6WB92_CIOIN methyltransferase-like protein 5 isoform X4 OS=Ciona intestinalis OX=7719 GN=LOC100184601 PE=
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.1 0.0 2.7e-05 0.045 4 74 .. 51 123 .. 49 131 .. 0.78
Alignments for each domain:
== domain 1 score: 13.1 bits; conditional E-value: 2.7e-05
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSE.EEEES-C..CCHHHHCS-TTSEE CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNl.rilrgda..lkvllelledgsle 74
v+++GcG G + + + + + +lGi+i ++ ++ ++ ea+el+N+ ++++ d + ++++ ++++
tr|F6WB92|F6WB92_CIOIN 51 NVCDLGCGCGILSIGSSLLGA-NHCLGIDIDEDALEIFQSNCEAYELNNVvECIQADIarFSPSRNMILAKRFD 123
589*******99999887765.68*************************6379999983333344555555555 PP
>> tr|F6VYQ8|F6VYQ8_CIOIN uncharacterized protein LOC100177375 OS=Ciona intestinalis OX=7719 GN=LOC100177375 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 6.2 0.0 0.0036 6.1 4 23 .. 82 101 .. 79 134 .. 0.86
2 ? 5.2 0.0 0.0071 12 94 121 .. 159 186 .. 158 233 .. 0.81
Alignments for each domain:
== domain 1 score: 6.2 bits; conditional E-value: 0.0036
EEEEET-TTSHHHHHHHHHS CS
Methyltransf_4 4 vvleiGcGkGeflvalAkkn 23
+vl+iG G G++ +al+k +
tr|F6VYQ8|F6VYQ8_CIOIN 82 TVLDIGAGTGQMAIALSKIQ 101
799*************9965 PP
== domain 2 score: 5.2 bits; conditional E-value: 0.0071
TTSHHHHHHHHHHEEEEEEEEEEESHHH CS
Methyltransf_4 94 llqpellkelarvLkkgGvlelaTDvee 121
l+qpe l ++ rv k gG+l++ T +
tr|F6VYQ8|F6VYQ8_CIOIN 159 LIQPECLPDMVRVVKCGGLLYFTTRATD 186
79********************885444 PP
>> tr|F6TU78|F6TU78_CIOIN Uncharacterized protein OS=Ciona intestinalis OX=7719 PE=4 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.7 0.2 7.3e-05 0.12 40 115 .. 41 119 .. 5 121 .. 0.75
Alignments for each domain:
== domain 1 score: 11.7 bits; conditional E-value: 7.3e-05
HHHHHHHHCTTSSEEEEE.S-C...CCHHHHCS-TTSEEEEEEES-----SGGGGGGSTTSHHHHHHHHHHEEEEEEEEE CS
Methyltransf_4 40 kvlkkiealelkNlrilr.gda...lkvllelledgslekifilFPDPwfKkrhhKrRllqpellkelarvLkkgGvlel 115
+++k++ +l+ + +l+ da + l+e+l ++++eki ++FP K+ +K R l +++ +++vL + G +e+
tr|F6TU78|F6TU78_CIOIN 41 EANKNMTELKRHGAIVLNgVDAtklHQNLSEFL-PKKFEKIIFNFPHTGRKASIRKNRELLRNFFLSAKEVLDQWGKIEV 119
555555555444433333157733333455555.569*********************9999999999****99999875 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (173 nodes)
Target sequences: 16678 (5370518 residues searched)
Passed MSV filter: 639 (0.0383139); expected 333.6 (0.02)
Passed bias filter: 414 (0.0248231); expected 333.6 (0.02)
Passed Vit filter: 39 (0.00233841); expected 16.7 (0.001)
Passed Fwd filter: 10 (0.000599592); expected 0.2 (1e-05)
Initial search space (Z): 16678 [actual number of targets]
Domain search space (domZ): 10 [number of targets reported over threshold]
# CPU time: 0.09u 0.00s 00:00:00.09 Elapsed: 00:00:00.03
# Mc/sec: 30969.99
//
[ok]