# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_4.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_4 [M=173] Accession: PF02390.16 Description: Putative methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 5.7e-58 197.4 0.0 7.7e-58 197.0 0.0 1.2 1 sp|Q9UBP6|TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransfera 4.6e-27 96.8 0.0 9.8e-25 89.2 0.0 2.0 1 tr|H0YIH0|H0YIH0_HUMAN tRNA (guanine-N(7)-)-methyltransfera 4.5e-10 41.5 0.0 4.5e-10 41.5 0.0 1.1 1 tr|H0YHU4|H0YHU4_HUMAN tRNA (guanine-N(7)-)-methyltransfera 6.3e-05 24.8 0.0 0.00011 24.0 0.0 1.3 1 sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyl 7.3e-05 24.5 0.0 0.00013 23.8 0.0 1.3 1 sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase h 0.00029 22.6 0.0 0.00052 21.8 0.0 1.4 1 tr|H3BQF6|H3BQF6_HUMAN Uncharacterized protein (Fragment) O 0.00089 21.0 0.0 0.0015 20.3 0.0 1.4 1 sp|Q5JPI9|MET10_HUMAN Methyltransferase-like protein 10 OS 0.0014 20.4 0.0 0.0034 19.1 0.0 1.6 1 sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member 0.0025 19.6 0.0 0.004 18.9 0.0 1.3 1 sp|Q96GJ1-3|TRM2_HUMAN Isoform 3 of tRNA (uracil(54)-C(5))- 0.0028 19.4 0.0 0.0045 18.7 0.0 1.3 1 tr|F2Z384|F2Z384_HUMAN tRNA (uracil(54)-C(5))-methyltransfe 0.0028 19.4 0.0 0.0045 18.7 0.0 1.3 1 sp|Q96GJ1-2|TRM2_HUMAN Isoform 2 of tRNA (uracil(54)-C(5))- 0.0028 19.4 0.0 0.0046 18.7 0.0 1.3 1 sp|Q96GJ1|TRM2_HUMAN tRNA (uracil(54)-C(5))-methyltransfe 0.0073 18.0 0.1 0.0097 17.6 0.1 1.2 1 tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS= 0.0079 17.9 0.0 0.034 15.9 0.0 1.8 2 tr|H7C258|H7C258_HUMAN HemK methyltransferase family member ------ inclusion threshold ------ 0.01 17.5 0.0 0.017 16.9 0.0 1.3 1 tr|B8ZZE3|B8ZZE3_HUMAN Methyltransferase like 5, isoform CR 0.012 17.4 0.0 0.019 16.7 0.0 1.3 1 sp|Q9NRN9|METL5_HUMAN Methyltransferase-like protein 5 OS= 0.016 16.9 0.0 0.026 16.3 0.0 1.3 1 tr|B8ZZC8|B8ZZC8_HUMAN Methyltransferase-like protein 5 OS= 0.029 16.1 0.0 0.058 15.1 0.0 1.4 1 sp|Q8NEC7-3|GSTCD_HUMAN Isoform 2 of Glutathione S-transfera 0.037 15.8 0.0 0.071 14.8 0.0 1.4 1 sp|Q8NEC7|GSTCD_HUMAN Glutathione S-transferase C-terminal 0.048 15.4 0.0 0.081 14.6 0.0 1.3 1 tr|H3BSS9|H3BSS9_HUMAN Protein arginine N-methyltransferase 0.075 14.7 0.0 0.14 13.9 0.0 1.4 1 tr|H3BPZ8|H3BPZ8_HUMAN Protein arginine N-methyltransferase 0.1 14.3 0.0 0.14 13.8 0.0 1.1 1 tr|H3BQ55|H3BQ55_HUMAN UPF0585 protein C16orf13 (Fragment) 0.11 14.2 0.0 0.14 13.8 0.0 1.1 1 tr|H3BNT3|H3BNT3_HUMAN UPF0585 protein C16orf13 (Fragment) 0.11 14.2 0.0 0.17 13.6 0.0 1.2 1 tr|H3BNB2|H3BNB2_HUMAN UPF0585 protein C16orf13 (Fragment) 0.12 14.1 0.0 0.17 13.6 0.0 1.2 1 tr|H3BMF3|H3BMF3_HUMAN UPF0585 protein C16orf13 (Fragment) 0.13 13.9 0.0 0.19 13.4 0.0 1.2 1 sp|Q96S19-6|CP013_HUMAN Isoform 6 of UPF0585 protein C16orf1 0.14 13.9 0.0 0.2 13.3 0.0 1.2 1 tr|H3BSC6|H3BSC6_HUMAN Alpha-1,2-mannosyltransferase ALG9 O 0.15 13.7 0.0 0.23 13.2 0.0 1.2 1 sp|Q96S19|CP013_HUMAN UPF0585 protein C16orf13 OS=Homo sap 0.16 13.7 0.0 0.23 13.2 0.0 1.2 1 sp|Q96S19-4|CP013_HUMAN Isoform 4 of UPF0585 protein C16orf1 0.2 13.4 0.6 6.4 8.5 0.0 2.3 2 tr|F2Z2W7|F2Z2W7_HUMAN tRNA (uracil-5-)-methyltransferase h 0.2 13.4 0.1 0.57 11.9 0.0 1.8 2 tr|H3BNC0|H3BNC0_HUMAN Protein arginine N-methyltransferase 0.21 13.3 0.1 0.57 11.9 0.0 1.7 2 sp|Q9NVM4-4|ANM7_HUMAN Isoform 4 of Protein arginine N-meth 0.29 12.8 0.0 0.51 12.0 0.0 1.4 1 sp|Q9NR22-2|ANM8_HUMAN Isoform 2 of Protein arginine N-meth 0.3 12.8 0.0 0.53 12.0 0.0 1.4 1 sp|Q9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 0.31 12.7 0.1 0.46 12.2 0.1 1.3 1 tr|E9PNR9|E9PNR9_HUMAN Protein arginine N-methyltransferase 0.32 12.7 1.6 2.4 9.8 0.0 2.5 2 sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS 0.39 12.4 0.2 0.66 11.7 0.1 1.5 2 tr|H3BRQ9|H3BRQ9_HUMAN Protein arginine N-methyltransferase 0.43 12.3 0.0 0.74 11.5 0.0 1.3 1 sp|Q9BRP7|FDXA1_HUMAN Ferredoxin-fold anticodon-binding do 0.5 12.1 0.1 0.77 11.5 0.1 1.3 1 tr|E9PQ98|E9PQ98_HUMAN Protein arginine N-methyltransferase 0.51 12.0 0.1 0.8 11.4 0.1 1.3 1 tr|E9PIX6|E9PIX6_HUMAN Protein arginine N-methyltransferase 0.55 11.9 0.0 0.83 11.3 0.0 1.2 1 tr|H7C100|H7C100_HUMAN tRNA (uracil-5-)-methyltransferase h 0.55 11.9 0.1 0.99 11.1 0.1 1.5 1 tr|E9PMW9|E9PMW9_HUMAN Protein arginine N-methyltransferase 0.58 11.9 0.0 0.85 11.3 0.0 1.2 1 tr|H7C3E5|H7C3E5_HUMAN Mediator of RNA polymerase II transc 0.62 11.8 0.1 1 11.1 0.1 1.3 1 tr|H0YDE4|H0YDE4_HUMAN Protein arginine N-methyltransferase 0.65 11.7 0.1 1.1 11.0 0.1 1.4 1 tr|E9PI83|E9PI83_HUMAN Protein arginine N-methyltransferase Domain annotation for each sequence (and alignments): >> sp|Q9UBP6|TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransferase OS=Homo sapiens GN=METTL1 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 197.0 0.0 3.9e-61 7.7e-58 2 172 .. 77 253 .. 76 254 .. 0.98 Alignments for each domain: == domain 1 score: 197.0 bits; conditional E-value: 3.9e-61 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC......TTSSEEEEES-CCCHHHHCS-TTSEEEEEEES---- CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal......elkNlrilrgdalkvllelledgslekifilFPDPw 84 ++ +++iGcG+G++lv+l++ +Pd+++lG+Eirvkv+++v ++i+al +++N+++lr++a+k+l++++ +g+l+k+f+lFPDP+ sp|Q9UBP6|TRMB_HUMAN 77 QVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALraapagGFQNIACLRSNAMKHLPNFFYKGQLTKMFFLFPDPH 165 6789************************************************************************************* PP -SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTTEEESSCCCSCCTCHCHHCCCSSTTCCCCCCTTSS-EE CS Methyltransf_4 85 fKkrhhKrRllqpellkelarvLkkgGvlelaTDveeyaeemlkvleeeplferlskeeeleeeplsvlriatkyeqkvqskgkeiye 172 fK+ +hK+R+++p+ll+e+a+vL++gG+++++TDv e++ +m++++ee+plfer+ e+ e++ + +l +t++++kv ++g++ + sp|Q9UBP6|TRMB_HUMAN 166 FKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFP 253 ***********************************************************************************99886 PP >> tr|H0YIH0|H0YIH0_HUMAN tRNA (guanine-N(7)-)-methyltransferase (Fragment) OS=Homo sapiens GN=METTL1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 89.2 0.0 5e-28 9.8e-25 48 172 .. 8 118 .. 2 119 .. 0.95 Alignments for each domain: == domain 1 score: 89.2 bits; conditional E-value: 5e-28 CTTSSEEEEES-CCCHHHHCS-TTSEEEEEEES-----SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCST CS Methyltransf_4 48 lelkNlrilrgdalkvllelledgslekifilFPDPwfKkrhhKrRllqpellkelarvLkkgGvlelaTDveeyaeemlkvleeep 134 +++N+++lr++a+k+l++++ +g+ + +hK+R+++p+ll+e+a+vL++gG+++++TDv e++ +m++++ee+p tr|H0YIH0|H0YIH0_HUMAN 8 GGFQNIACLRSNAMKHLPNFFYKGQ--------------RTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHP 80 589********************76..............6789******************************************** PP TEEESSCCCSCCTCHCHHCCCSSTTCCCCCCTTSS-EE CS Methyltransf_4 135 lferlskeeeleeeplsvlriatkyeqkvqskgkeiye 172 lfer+ e+ e++ + +l +t++++kv ++g++ + tr|H0YIH0|H0YIH0_HUMAN 81 LFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFP 118 **********************************9886 PP >> tr|H0YHU4|H0YHU4_HUMAN tRNA (guanine-N(7)-)-methyltransferase (Fragment) OS=Homo sapiens GN=METTL1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 41.5 0.0 2.3e-13 4.5e-10 81 114 .. 2 35 .. 1 52 [. 0.94 Alignments for each domain: == domain 1 score: 41.5 bits; conditional E-value: 2.3e-13 -----SGGGGGGSTTSHHHHHHHHHHEEEEEEEE CS Methyltransf_4 81 PDPwfKkrhhKrRllqpellkelarvLkkgGvle 114 PDP+fK+ +hK+R+++p+ll+e+a+vL++gG + tr|H0YHU4|H0YHU4_HUMAN 2 PDPHFKRTKHKWRIISPTLLAEYAYVLRVGGDFA 35 9******************************875 PP >> sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.0 0.0 5.6e-08 0.00011 3 69 .. 434 498 .. 432 510 .. 0.87 Alignments for each domain: == domain 1 score: 24.0 bits; conditional E-value: 5.6e-08 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS- CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelle 69 ++vl+++cG G++ +alA k k ++G+E+ + v+ + +++++el+N++ ++g a +++++l++ sp|Q8IZ69-2|TRM2A_HUMAN 434 SMVLDVCCGTGTIGLALARK--VKRVIGVELCPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLVS 498 579********988887776..689*********************************888777665 PP >> sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 23.8 0.0 6.5e-08 0.00013 3 69 .. 434 498 .. 432 510 .. 0.87 Alignments for each domain: == domain 1 score: 23.8 bits; conditional E-value: 6.5e-08 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS- CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelle 69 ++vl+++cG G++ +alA k k ++G+E+ + v+ + +++++el+N++ ++g a +++++l++ sp|Q8IZ69|TRM2A_HUMAN 434 SMVLDVCCGTGTIGLALARK--VKRVIGVELCPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLVS 498 579********988887776..689*********************************888777665 PP >> tr|H3BQF6|H3BQF6_HUMAN Uncharacterized protein (Fragment) OS=Homo sapiens PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.8 0.0 2.7e-07 0.00052 4 112 .. 47 151 .. 45 178 .. 0.79 Alignments for each domain: == domain 1 score: 21.8 bits; conditional E-value: 2.7e-07 EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-C......CCHHHHCS-TTSEEEEEEES---- CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgda......lkvllelledgslekifilFPDPw 84 vl+iG+G+G flv+lAk + n+ Gi+ + + ++ + ie+++l+N+++ d l ++ + +g+++ i+++ PD tr|H3BQF6|H3BQF6_HUMAN 47 SVLDIGTGNGVFLVELAK-FGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFlnlstqLSGFHICIDKGTFDAISLN-PDNA 131 689**************7.67889****************************999986665555566777888888888887.7777 PP -SGGGGGGSTTSHHHHHHHHHHEEEEEE CS Methyltransf_4 85 fKkrhhKrRllqpellkelarvLkkgGv 112 ++kr+ + +k l rvLk++G+ tr|H3BQF6|H3BQF6_HUMAN 132 IEKRK--------QYVKSLSRVLKVKGF 151 77777........556666666666665 PP >> sp|Q5JPI9|MET10_HUMAN Methyltransferase-like protein 10 OS=Homo sapiens GN=METTL10 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 20.3 0.0 7.8e-07 0.0015 4 104 .. 82 178 .. 80 207 .. 0.79 Alignments for each domain: == domain 1 score: 20.3 bits; conditional E-value: 7.8e-07 EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-C......CCHHHHCS-TTSEEEEEEES----- CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgda......lkvllelledgslekifilFPDPwf 85 vl+iG+G+G flv+lAk + n+ Gi+ + + ++ + ie+++l+N+++ d l ++ + +g+++ i+++ PD + sp|Q5JPI9|MET10_HUMAN 82 SVLDIGTGNGVFLVELAK-FGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFlnlstqLSGFHICIDKGTFDAISLN-PDNAI 167 689**************7.67889****************************999985555555556667888888888877.77777 PP SGGGGGGSTTSHHHHHHHH CS Methyltransf_4 86 KkrhhKrRllqpellkela 104 +kr+ + +k l sp|Q5JPI9|MET10_HUMAN 168 EKRK--------QYVKSLS 178 6666........4455555 PP >> sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member 1 OS=Homo sapiens GN=HEMK1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.1 0.0 1.7e-06 0.0034 3 51 .. 161 209 .. 159 221 .. 0.90 Alignments for each domain: == domain 1 score: 19.1 bits; conditional E-value: 1.7e-06 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTS CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelk 51 p++le+GcG+G + + l + P+ ++++++r+ + +++++l+l+ sp|Q9Y5R4|HEMK1_HUMAN 161 PLILEVGCGSGAISLSLLSQLPQSRVIAVDKREAAISLTHENAQRLRLQ 209 899*********************************9999999999887 PP >> sp|Q96GJ1-3|TRM2_HUMAN Isoform 3 of tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Homo sapiens GN=TRMT2B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.9 0.0 2e-06 0.004 3 70 .. 301 366 .. 299 374 .. 0.89 Alignments for each domain: == domain 1 score: 18.9 bits; conditional E-value: 2e-06 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-T CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelled 70 ++l+i+cG G + + lA++ +lGiE+ ++ v+ + +++ ++++N + + g a k+l+ ll+ sp|Q96GJ1-3|TRM2_HUMAN 301 TILLDICCGTGVIGLSLAQHT--SRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKS 366 689********8888888876..678********************************9999988875 PP >> tr|F2Z384|F2Z384_HUMAN tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Homo sapiens GN=TRMT2B PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.7 0.0 2.3e-06 0.0045 3 70 .. 346 411 .. 344 419 .. 0.89 Alignments for each domain: == domain 1 score: 18.7 bits; conditional E-value: 2.3e-06 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-T CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelled 70 ++l+i+cG G + + lA++ +lGiE+ ++ v+ + +++ ++++N + + g a k+l+ ll+ tr|F2Z384|F2Z384_HUMAN 346 TILLDICCGTGVIGLSLAQHT--SRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKS 411 689********8888888876..678********************************9999988875 PP >> sp|Q96GJ1-2|TRM2_HUMAN Isoform 2 of tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Homo sapiens GN=TRMT2B # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.7 0.0 2.3e-06 0.0045 3 70 .. 346 411 .. 344 419 .. 0.89 Alignments for each domain: == domain 1 score: 18.7 bits; conditional E-value: 2.3e-06 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-T CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelled 70 ++l+i+cG G + + lA++ +lGiE+ ++ v+ + +++ ++++N + + g a k+l+ ll+ sp|Q96GJ1-2|TRM2_HUMAN 346 TILLDICCGTGVIGLSLAQHT--SRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKS 411 689********8888888876..678********************************9999988875 PP >> sp|Q96GJ1|TRM2_HUMAN tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Homo sapiens GN=TRMT2B PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 18.7 0.0 2.3e-06 0.0046 3 70 .. 346 411 .. 344 419 .. 0.89 Alignments for each domain: == domain 1 score: 18.7 bits; conditional E-value: 2.3e-06 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-T CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelled 70 ++l+i+cG G + + lA++ +lGiE+ ++ v+ + +++ ++++N + + g a k+l+ ll+ sp|Q96GJ1|TRM2_HUMAN 346 TILLDICCGTGVIGLSLAQHT--SRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKS 411 689********8888888876..678********************************9999988875 PP >> tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.6 0.1 4.9e-06 0.0097 2 79 .. 52 126 .. 51 136 .. 0.89 Alignments for each domain: == domain 1 score: 17.6 bits; conditional E-value: 4.9e-06 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-TTSEEEEEEE CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelledgslekifil 79 ++vv+++GcG G + + A + +++G +i ++ ++ ++++e+ el+N+ +++ d +l++ +++ s++ + ++ tr|E7EMN2|E7EMN2_HUMAN 52 NKVVADLGCGCGVLSIGTAMLGA-GLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDV-CLLSNRMSK-SFDTVIMN 126 689**************998776.689*******************************6.899999888.77777776 PP >> tr|H7C258|H7C258_HUMAN HemK methyltransferase family member 1 (Fragment) OS=Homo sapiens GN=HEMK1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 15.9 0.0 1.7e-05 0.034 5 45 .. 1 41 [. 1 51 [. 0.88 2 ? -0.1 0.0 1.4 2.7e+03 98 123 .. 62 89 .. 59 109 .. 0.76 Alignments for each domain: == domain 1 score: 15.9 bits; conditional E-value: 1.7e-05 EEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHH CS Methyltransf_4 5 vleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkki 45 +le+GcG+G + + l + P+ ++++++r+ + +++ tr|H7C258|H7C258_HUMAN 1 ILEVGCGSGAISLSLLSQLPQSRVIAVDKREAAISLTHENA 41 58****************************99987666655 PP == domain 2 score: -0.1 bits; conditional E-value: 1.4 HHHHHHHHHEEEEEEEEEEES..HHHHH CS Methyltransf_4 98 ellkelarvLkkgGvlelaTD..veeya 123 ++l+ + r Lk +G++ l D ++e+ tr|H7C258|H7C258_HUMAN 62 HILALAPRLLKDSGSIFLEVDprHPELV 89 6778888999999*99999997755554 PP >> tr|B8ZZE3|B8ZZE3_HUMAN Methyltransferase like 5, isoform CRA_b OS=Homo sapiens GN=METTL5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.9 0.0 8.5e-06 0.017 2 79 .. 52 126 .. 51 130 .. 0.89 Alignments for each domain: == domain 1 score: 16.9 bits; conditional E-value: 8.5e-06 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-TTSEEEEEEE CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelledgslekifil 79 ++vv+++GcG G + + A + +++G +i ++ ++ ++++e+ el+N+ +++ d +l++ +++ s++ + ++ tr|B8ZZE3|B8ZZE3_HUMAN 52 NKVVADLGCGCGVLSIGTAMLGA-GLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDV-CLLSNRMSK-SFDTVIMN 126 689**************998776.689*******************************6.899999887.77777765 PP >> sp|Q9NRN9|METL5_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.7 0.0 9.6e-06 0.019 2 79 .. 52 126 .. 51 130 .. 0.89 Alignments for each domain: == domain 1 score: 16.7 bits; conditional E-value: 9.6e-06 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-TTSEEEEEEE CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelledgslekifil 79 ++vv+++GcG G + + A + +++G +i ++ ++ ++++e+ el+N+ +++ d +l++ +++ s++ + ++ sp|Q9NRN9|METL5_HUMAN 52 NKVVADLGCGCGVLSIGTAMLGA-GLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDV-CLLSNRMSK-SFDTVIMN 126 689**************998776.689*******************************6.899999887.77777665 PP >> tr|B8ZZC8|B8ZZC8_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 16.3 0.0 1.3e-05 0.026 2 79 .. 52 126 .. 51 130 .. 0.89 Alignments for each domain: == domain 1 score: 16.3 bits; conditional E-value: 1.3e-05 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-TTSEEEEEEE CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelledgslekifil 79 ++vv+++GcG G + + A + +++G +i ++ ++ ++++e+ el+N+ +++ d +l++ +++ s++ + ++ tr|B8ZZC8|B8ZZC8_HUMAN 52 NKVVADLGCGCGVLSIGTAMLGA-GLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDV-CLLSNRMSK-SFDTVIMN 126 689**************998776.689*******************************6.899998887.77777665 PP >> sp|Q8NEC7-3|GSTCD_HUMAN Isoform 2 of Glutathione S-transferase C-terminal domain-containing protein OS=Homo sapiens # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.1 0.0 3e-05 0.058 5 69 .. 358 421 .. 355 424 .. 0.95 Alignments for each domain: == domain 1 score: 15.1 bits; conditional E-value: 3e-05 EEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS- CS Methyltransf_4 5 vleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelle 69 +++ ++G G++ + lA++ P++++ iE ++ ++ ++ k+ ++l+l+N+ ++ + +++++ +++ sp|Q8NEC7-3|GSTCD_HUMAN 358 IVDFCSGGGHVGIVLAHMLPSCQVTLIENKELSLIRAKKRSDELGLSNIWFIQAN-MEYFTGMFN 421 699****************************************************.799998885 PP >> sp|Q8NEC7|GSTCD_HUMAN Glutathione S-transferase C-terminal domain-containing protein OS=Homo sapiens GN=GSTCD PE=1 S # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.8 0.0 3.6e-05 0.071 5 69 .. 445 508 .. 442 511 .. 0.95 Alignments for each domain: == domain 1 score: 14.8 bits; conditional E-value: 3.6e-05 EEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS- CS Methyltransf_4 5 vleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelle 69 +++ ++G G++ + lA++ P++++ iE ++ ++ ++ k+ ++l+l+N+ ++ + +++++ +++ sp|Q8NEC7|GSTCD_HUMAN 445 IVDFCSGGGHVGIVLAHMLPSCQVTLIENKELSLIRAKKRSDELGLSNIWFIQAN-MEYFTGMFN 508 699****************************************************.799998885 PP >> tr|H3BSS9|H3BSS9_HUMAN Protein arginine N-methyltransferase 7 (Fragment) OS=Homo sapiens GN=PRMT7 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 14.6 0.0 4.1e-05 0.081 2 51 .. 65 113 .. 64 127 .. 0.84 Alignments for each domain: == domain 1 score: 14.6 bits; conditional E-value: 4.1e-05 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTS CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelk 51 + +vl+iG+G G +l+ +A + +iE+ +++ ++++k +e+++++ tr|H3BSS9|H3BSS9_HUMAN 65 KALVLDIGTGTG-LLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFS 113 6799******99.68889**************************999764 PP >> tr|H3BPZ8|H3BPZ8_HUMAN Protein arginine N-methyltransferase 7 (Fragment) OS=Homo sapiens GN=PRMT7 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.9 0.0 7e-05 0.14 2 51 .. 65 113 .. 64 127 .. 0.84 Alignments for each domain: == domain 1 score: 13.9 bits; conditional E-value: 7e-05 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTS CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelk 51 + +vl+iG+G G +l+ +A + +iE+ +++ ++++k +e+++++ tr|H3BPZ8|H3BPZ8_HUMAN 65 KALVLDIGTGTG-LLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFS 113 6789******99.68889**************************999664 PP >> tr|H3BQ55|H3BQ55_HUMAN UPF0585 protein C16orf13 (Fragment) OS=Homo sapiens GN=C16orf13 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.8 0.0 7.4e-05 0.14 3 54 .. 19 70 .. 17 76 .. 0.95 Alignments for each domain: == domain 1 score: 13.8 bits; conditional E-value: 7.4e-05 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 + vle+ +G+G++ + A ++P ++ ++ ++ ++ + ++ +a++l+N++ tr|H3BQ55|H3BQ55_HUMAN 19 VRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVK 70 5689**********************************************97 PP >> tr|H3BNT3|H3BNT3_HUMAN UPF0585 protein C16orf13 (Fragment) OS=Homo sapiens GN=C16orf13 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.8 0.0 7.4e-05 0.14 3 54 .. 11 62 .. 9 68 .. 0.95 Alignments for each domain: == domain 1 score: 13.8 bits; conditional E-value: 7.4e-05 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 + vle+ +G+G++ + A ++P ++ ++ ++ ++ + ++ +a++l+N++ tr|H3BNT3|H3BNT3_HUMAN 11 VRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVK 62 5689**********************************************97 PP >> tr|H3BNB2|H3BNB2_HUMAN UPF0585 protein C16orf13 (Fragment) OS=Homo sapiens GN=C16orf13 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.6 0.0 8.5e-05 0.17 3 54 .. 29 80 .. 27 86 .. 0.95 Alignments for each domain: == domain 1 score: 13.6 bits; conditional E-value: 8.5e-05 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 + vle+ +G+G++ + A ++P ++ ++ ++ ++ + ++ +a++l+N++ tr|H3BNB2|H3BNB2_HUMAN 29 VRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVK 80 5689**********************************************97 PP >> tr|H3BMF3|H3BMF3_HUMAN UPF0585 protein C16orf13 (Fragment) OS=Homo sapiens GN=C16orf13 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.6 0.0 8.7e-05 0.17 3 54 .. 12 63 .. 10 69 .. 0.95 Alignments for each domain: == domain 1 score: 13.6 bits; conditional E-value: 8.7e-05 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 + vle+ +G+G++ + A ++P ++ ++ ++ ++ + ++ +a++l+N++ tr|H3BMF3|H3BMF3_HUMAN 12 VRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVK 63 5689**********************************************97 PP >> sp|Q96S19-6|CP013_HUMAN Isoform 6 of UPF0585 protein C16orf13 OS=Homo sapiens GN=C16orf13 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.4 0.0 9.6e-05 0.19 3 54 .. 29 80 .. 27 86 .. 0.95 Alignments for each domain: == domain 1 score: 13.4 bits; conditional E-value: 9.6e-05 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 + vle+ +G+G++ + A ++P ++ ++ ++ ++ + ++ +a++l+N++ sp|Q96S19-6|CP013_HUMAN 29 VRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVK 80 5689**********************************************97 PP >> tr|H3BSC6|H3BSC6_HUMAN Alpha-1,2-mannosyltransferase ALG9 OS=Homo sapiens GN=ALG9 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.3 0.0 0.0001 0.2 49 116 .. 47 124 .. 21 125 .. 0.76 Alignments for each domain: == domain 1 score: 13.3 bits; conditional E-value: 0.0001 TTSSEEEEES-C........CCHHHHCS..-TTSEEEEEEES-----SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEE CS Methyltransf_4 49 elkNlrilrgda........lkvllell..edgslekifilFPDPwfKkrhhKrRllqpellkelarvLkkgGvlela 116 +Nl++lr ++l +++ +++++++i++ FP K+ K R l ++ + a+vL ++G++++a tr|H3BSC6|H3BSC6_HUMAN 47 AWENLQCLRERGidvrfgvdCTQLADVFelHEREFDQIYFIFPHCGRKAGVAKNRELLAKFFQSCADVLAEEGEVHVA 124 5666666666555556666666777776225889*****************************************985 PP >> sp|Q96S19|CP013_HUMAN UPF0585 protein C16orf13 OS=Homo sapiens GN=C16orf13 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.2 0.0 0.00012 0.23 3 54 .. 29 80 .. 27 86 .. 0.95 Alignments for each domain: == domain 1 score: 13.2 bits; conditional E-value: 0.00012 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 + vle+ +G+G++ + A ++P ++ ++ ++ ++ + ++ +a++l+N++ sp|Q96S19|CP013_HUMAN 29 VRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVK 80 5689**********************************************97 PP >> sp|Q96S19-4|CP013_HUMAN Isoform 4 of UPF0585 protein C16orf13 OS=Homo sapiens GN=C16orf13 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.2 0.0 0.00012 0.23 3 54 .. 29 80 .. 27 86 .. 0.95 Alignments for each domain: == domain 1 score: 13.2 bits; conditional E-value: 0.00012 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 + vle+ +G+G++ + A ++P ++ ++ ++ ++ + ++ +a++l+N++ sp|Q96S19-4|CP013_HUMAN 29 VRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVK 80 5689**********************************************97 PP >> tr|F2Z2W7|F2Z2W7_HUMAN tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 2.8 0.2 0.18 3.5e+02 3 21 .. 434 452 .. 432 455 .. 0.88 2 ? 8.5 0.0 0.0033 6.4 26 69 .. 473 516 .. 469 528 .. 0.87 Alignments for each domain: == domain 1 score: 2.8 bits; conditional E-value: 0.18 EEEEEET-TTSHHHHHHHH CS Methyltransf_4 3 pvvleiGcGkGeflvalAk 21 ++vl+++cG G++ +alA tr|F2Z2W7|F2Z2W7_HUMAN 434 SMVLDVCCGTGTIGLALAR 452 579*********9999985 PP == domain 2 score: 8.5 bits; conditional E-value: 0.0033 SEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS- CS Methyltransf_4 26 knflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelle 69 k ++G+E+ + v+ + +++++el+N++ ++g a +++++l++ tr|F2Z2W7|F2Z2W7_HUMAN 473 KRVIGVELCPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLVS 516 579********************************888777665 PP >> tr|H3BNC0|H3BNC0_HUMAN Protein arginine N-methyltransferase 7 OS=Homo sapiens GN=PRMT7 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.0 0.00029 0.57 2 51 .. 65 113 .. 64 127 .. 0.84 2 ? -2.8 0.0 9.6 1.9e+04 9 34 .. 407 432 .. 390 461 .. 0.53 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.00029 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTS CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelk 51 + +vl+iG+G G +l+ +A + +iE+ +++ ++++k +e+++++ tr|H3BNC0|H3BNC0_HUMAN 65 KALVLDIGTGTG-LLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFS 113 6789******99.68889**************************999664 PP == domain 2 score: -2.8 bits; conditional E-value: 9.6 T-TTSHHHHHHHHHSTTSEEEEEES- CS Methyltransf_4 9 GcGkGeflvalAkknPdknflGiEir 34 ++ G++l+ lA++ +++ +E + tr|H3BNC0|H3BNC0_HUMAN 407 CVSDGSLLSVLAHHLGVEQVFTVESS 432 44444444444444444444444433 PP >> sp|Q9NVM4-4|ANM7_HUMAN Isoform 4 of Protein arginine N-methyltransferase 7 OS=Homo sapiens GN=PRMT7 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.9 0.0 0.00029 0.57 2 51 .. 65 113 .. 64 127 .. 0.84 2 ? -2.8 0.0 9.6 1.9e+04 9 34 .. 407 432 .. 390 461 .. 0.53 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 0.00029 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTS CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelk 51 + +vl+iG+G G +l+ +A + +iE+ +++ ++++k +e+++++ sp|Q9NVM4-4|ANM7_HUMAN 65 KALVLDIGTGTG-LLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFS 113 6789******99.68889**************************999664 PP == domain 2 score: -2.8 bits; conditional E-value: 9.6 T-TTSHHHHHHHHHSTTSEEEEEES- CS Methyltransf_4 9 GcGkGeflvalAkknPdknflGiEir 34 ++ G++l+ lA++ +++ +E + sp|Q9NVM4-4|ANM7_HUMAN 407 CVSDGSLLSVLAHHLGVEQVFTVESS 432 44444444444444444444444433 PP >> sp|Q9NR22-2|ANM8_HUMAN Isoform 2 of Protein arginine N-methyltransferase 8 OS=Homo sapiens GN=PRMT8 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.0 0.0 0.00026 0.51 2 57 .. 103 156 .. 102 168 .. 0.82 Alignments for each domain: == domain 1 score: 12.0 bits; conditional E-value: 0.00026 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEE CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilr 57 +vvl++G+G G + + A k k+++GiE + +++++ k i+a++l N+ ++ sp|Q9NR22-2|ANM8_HUMAN 103 DKVVLDVGSGTGIL-SMFAAKAGAKKVFGIECS-SISDYSEKIIKANHLDNIITIF 156 5799*******965.5566677778899***96.57899999999******98765 PP >> sp|Q9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 8 OS=Homo sapiens GN=PRMT8 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.0 0.0 0.00027 0.53 2 57 .. 112 165 .. 111 177 .. 0.82 Alignments for each domain: == domain 1 score: 12.0 bits; conditional E-value: 0.00027 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEE CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilr 57 +vvl++G+G G + + A k k+++GiE + +++++ k i+a++l N+ ++ sp|Q9NR22|ANM8_HUMAN 112 DKVVLDVGSGTGIL-SMFAAKAGAKKVFGIECS-SISDYSEKIIKANHLDNIITIF 165 5799*******965.5566677778899***96.57899999999******98765 PP >> tr|E9PNR9|E9PNR9_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.2 0.1 0.00024 0.46 2 52 .. 43 91 .. 42 105 .. 0.78 Alignments for each domain: == domain 1 score: 12.2 bits; conditional E-value: 0.00024 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSS CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkN 52 +vvl++G+G G + + Ak +++GiE + +++++++k ++a++l tr|E9PNR9|E9PNR9_HUMAN 43 DKVVLDVGSGTGILCMFAAK-AGARKVIGIECS-SISDYAVKIVKANKLDH 91 5799********87765555.566789****96.57899999999887765 PP >> sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS=Homo sapiens GN=THUMPD2 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 9.8 0.0 0.0012 2.4 6 49 .. 303 346 .. 299 361 .. 0.86 2 ? 0.8 0.0 0.71 1.4e+03 98 116 .. 389 407 .. 385 454 .. 0.71 Alignments for each domain: == domain 1 score: 9.8 bits; conditional E-value: 0.0012 EEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCT CS Methyltransf_4 6 leiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieale 49 l+ cG G++l++ Ak+ Pd+ ++G +++ + + +++ +a + sp|Q9BTF0|THUM2_HUMAN 303 LDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAG 346 5666*************************999998888887765 PP == domain 2 score: 0.8 bits; conditional E-value: 0.71 HHHHHHHHHEEEEEEEEEE CS Methyltransf_4 98 ellkelarvLkkgGvlela 116 +l+e++rvL++gG ++l sp|Q9BTF0|THUM2_HUMAN 389 SILQEMERVLHVGGTIVLL 407 5799**********99864 PP >> tr|H3BRQ9|H3BRQ9_HUMAN Protein arginine N-methyltransferase 7 OS=Homo sapiens GN=PRMT7 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -2.6 0.0 8.1 1.6e+04 120 129 .. 24 33 .. 17 55 .. 0.54 2 ? 11.7 0.1 0.00034 0.66 2 45 .. 65 107 .. 64 108 .] 0.89 Alignments for each domain: == domain 1 score: -2.6 bits; conditional E-value: 8.1 HHHHHHHHHH CS Methyltransf_4 120 eeyaeemlkv 129 ++y++e++ tr|H3BRQ9|H3BRQ9_HUMAN 24 YDYHQEIARS 33 3444444332 PP == domain 2 score: 11.7 bits; conditional E-value: 0.00034 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHH CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkki 45 + +vl+iG+G G +l+ +A + +iE+ +++ ++++k + tr|H3BRQ9|H3BRQ9_HUMAN 65 KALVLDIGTGTG-LLSMMAVTAGADFCYAIEVFKPMADAAVKIV 107 6799******99.68889******************99999865 PP >> sp|Q9BRP7|FDXA1_HUMAN Ferredoxin-fold anticodon-binding domain-containing protein 1 OS=Homo sapiens GN=FDXACB1 PE=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.5 0.0 0.00038 0.74 49 116 .. 47 124 .. 23 125 .. 0.76 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 0.00038 TTSSEEEEES-C........CCHHHHCS..-TTSEEEEEEES-----SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEE CS Methyltransf_4 49 elkNlrilrgda........lkvllell..edgslekifilFPDPwfKkrhhKrRllqpellkelarvLkkgGvlela 116 +Nl++lr ++l +++ +++++++i++ FP K+ K R l ++ + a+vL ++G++++a sp|Q9BRP7|FDXA1_HUMAN 47 AWENLQCLRERGidvrfgvdCTQLADVFelHEREFDQIYFIFPHCGRKAGVAKNRELLAKFFQSCADVLAEEGEVHVA 124 5566666665555555555556677766225889*****************************************975 PP >> tr|E9PQ98|E9PQ98_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.5 0.1 0.00039 0.77 2 52 .. 43 91 .. 42 104 .. 0.78 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 0.00039 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSS CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkN 52 +vvl++G+G G + + Ak +++GiE + +++++++k ++a++l tr|E9PQ98|E9PQ98_HUMAN 43 DKVVLDVGSGTGILCMFAAK-AGARKVIGIECS-SISDYAVKIVKANKLDH 91 5799********87765555.566789****96.57899999998887765 PP >> tr|E9PIX6|E9PIX6_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.4 0.1 0.0004 0.8 2 52 .. 43 91 .. 42 104 .. 0.78 Alignments for each domain: == domain 1 score: 11.4 bits; conditional E-value: 0.0004 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSS CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkN 52 +vvl++G+G G + + Ak +++GiE + +++++++k ++a++l tr|E9PIX6|E9PIX6_HUMAN 43 DKVVLDVGSGTGILCMFAAK-AGARKVIGIECS-SISDYAVKIVKANKLDH 91 5799********87765555.566789****96.57899999998887765 PP >> tr|H7C100|H7C100_HUMAN tRNA (uracil-5-)-methyltransferase homolog A (Fragment) OS=Homo sapiens GN=TRMT2A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.3 0.0 0.00042 0.83 27 69 .. 4 46 .. 2 59 .. 0.87 Alignments for each domain: == domain 1 score: 11.3 bits; conditional E-value: 0.00042 EEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS- CS Methyltransf_4 27 nflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelle 69 ++G+E+ + v+ + +++++el+N++ ++g a +++++l++ tr|H7C100|H7C100_HUMAN 4 RVIGVELCPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLVS 46 68********************************888877765 PP >> tr|E9PMW9|E9PMW9_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.1 0.1 0.0005 0.99 2 46 .. 65 107 .. 64 110 .] 0.73 Alignments for each domain: == domain 1 score: 11.1 bits; conditional E-value: 0.0005 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHH CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkie 46 +vvl++G+G G + + Ak +++GiE ++ ++++++k ++ tr|E9PMW9|E9PMW9_HUMAN 65 DKVVLDVGSGTGILCMFAAK-AGARKVIGIECSS-ISDYAVKIVK 107 5799********87765555.556789****864.5666666665 PP >> tr|H7C3E5|H7C3E5_HUMAN Mediator of RNA polymerase II transcription subunit 14 (Fragment) OS=Homo sapiens GN=MED14 PE # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.3 0.0 0.00043 0.85 88 148 .. 116 175 .. 114 189 .. 0.80 Alignments for each domain: == domain 1 score: 11.3 bits; conditional E-value: 0.00043 GGGGGSTTSHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTTEEESSCCC.SCCTC CS Methyltransf_4 88 rhhKrRllqpellkelarvLkkgGvlelaTDveeyaeemlkvleeeplferlskee.eleee 148 r+h +R++q+e+l+ + + ++ Gv+ ++TD + +++++ +++ + ++ ++++ tr|H7C3E5|H7C3E5_HUMAN 116 RRHLQRIIQQETLQLINS--NEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAgQWKPD 175 889*************99..699*********999999999999998888776653144444 PP >> tr|H0YDE4|H0YDE4_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.1 0.1 0.00051 1 2 52 .. 99 147 .. 98 160 .. 0.78 Alignments for each domain: == domain 1 score: 11.1 bits; conditional E-value: 0.00051 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSS CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkN 52 +vvl++G+G G + + Ak +++GiE + +++++++k ++a++l tr|H0YDE4|H0YDE4_HUMAN 99 DKVVLDVGSGTGILCMFAAK-AGARKVIGIECS-SISDYAVKIVKANKLDH 147 5799********87765555.566789****96.57899999998887765 PP >> tr|E9PI83|E9PI83_HUMAN Protein arginine N-methyltransferase 1 (Fragment) OS=Homo sapiens GN=PRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.0 0.1 0.00053 1.1 2 46 .. 68 110 .. 67 113 .] 0.73 Alignments for each domain: == domain 1 score: 11.0 bits; conditional E-value: 0.00053 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHH CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkie 46 +vvl++G+G G + + Ak +++GiE ++ ++++++k ++ tr|E9PI83|E9PI83_HUMAN 68 DKVVLDVGSGTGILCMFAAK-AGARKVIGIECSS-ISDYAVKIVK 110 5799********87765555.556789****864.5666666665 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (173 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 2576 (0.0291162); expected 1769.5 (0.02) Passed bias filter: 1765 (0.0199496); expected 1769.5 (0.02) Passed Vit filter: 194 (0.00219276); expected 88.5 (0.001) Passed Fwd filter: 45 (0.00050863); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 45 [number of targets reported over threshold] # CPU time: 0.51u 0.02s 00:00:00.53 Elapsed: 00:00:00.21 # Mc/sec: 28891.43 // [ok]