# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_4.hmm.txt # target sequence database: proteomes/Monodelphis_domestica.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_4 [M=173] Accession: PF02390.16 Description: Putative methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 8.9e-59 198.1 0.0 1.1e-58 197.7 0.0 1.1 1 tr|H9H7Z1|H9H7Z1_MONDO tRNA (guanine-N(7)-)-methyltransferas 4.3e-06 26.6 0.3 1.4e-05 24.9 0.1 1.8 2 tr|F6S9Y2|F6S9Y2_MONDO tRNA methyltransferase 2 homolog A OS 9.7e-05 22.1 0.0 0.00015 21.5 0.0 1.2 1 tr|F7D1V9|F7D1V9_MONDO Uncharacterized protein OS=Monodelphi 0.0022 17.7 0.1 0.0032 17.2 0.1 1.2 1 tr|F6ZXU0|F6ZXU0_MONDO Methyltransferase like 5 OS=Monodelph 0.0031 17.2 0.0 0.0054 16.4 0.0 1.3 1 tr|F6ZAN7|F6ZAN7_MONDO Glutathione S-transferase C-terminal ------ inclusion threshold ------ 0.013 15.2 0.3 0.39 10.4 0.0 2.7 2 tr|F6Z8P9|F6Z8P9_MONDO Exportin 4 OS=Monodelphis domestica O 0.028 14.1 0.0 0.047 13.4 0.0 1.4 1 tr|F6SAW9|F6SAW9_MONDO EEF1A lysine methyltransferase 2 OS=M 0.051 13.3 0.0 0.18 11.5 0.0 1.8 2 tr|F7B9I4|F7B9I4_MONDO HemK methyltransferase family member 0.2 11.4 0.1 3.4 7.4 0.1 2.3 2 tr|F7FNT7|F7FNT7_MONDO NOP2/Sun RNA methyltransferase family 0.29 10.8 0.0 0.68 9.6 0.0 1.6 1 tr|F6R6T5|F6R6T5_MONDO Methylphosphate capping enzyme OS=Mon Domain annotation for each sequence (and alignments): >> tr|H9H7Z1|H9H7Z1_MONDO tRNA (guanine-N(7)-)-methyltransferase OS=Monodelphis domestica OX=13616 GN=METTL1 PE=3 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 197.7 0.0 5.4e-62 1.1e-58 2 172 .. 71 247 .. 70 248 .. 0.98 Alignments for each domain: == domain 1 score: 197.7 bits; conditional E-value: 5.4e-62 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC......TTSSEEEEES-CCCHHHHCS-TTSEEEEEEES-- CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal......elkNlrilrgdalkvllelledgslekifilFPD 82 ++ +++iGcG+G++lv+l++++P++++lG+Eirvkv+++v ++i+al +++N+++lr++a+k+l++++++g+l+k+f+lFPD tr|H9H7Z1|H9H7Z1_MONDO 71 QVEFADIGCGYGGLLVELSPMFPNTLILGLEIRVKVSDYVQDRIRALrstsggGFQNIACLRSNAMKHLPNFFHKGQLTKMFFLFPD 157 6789*********************************************************************************** PP ---SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTTEEESSCCCSCCTCHCHHCCCSSTTCCCCCCTTSS CS Methyltransf_4 83 PwfKkrhhKrRllqpellkelarvLkkgGvlelaTDveeyaeemlkvleeeplferlskeeeleeeplsvlriatkyeqkvqskgke 169 P+fK+ +hK+R+++p+ll+e+a+vL+ gG+++++TDv +++ ++++++ee+plfer+ +ee + ++++ +l +t++++kv ++g++ tr|H9H7Z1|H9H7Z1_MONDO 158 PHFKRTKHKWRIISPTLLAEYAYVLRIGGLVYTITDVMDLHSWICTHFEEHPLFERVPQEELVDDPIVGHLGTSTEEGKKVLRNGGK 244 *************************************************************************************99 PP -EE CS Methyltransf_4 170 iye 172 + tr|H9H7Z1|H9H7Z1_MONDO 245 NFP 247 886 PP >> tr|F6S9Y2|F6S9Y2_MONDO tRNA methyltransferase 2 homolog A OS=Monodelphis domestica OX=13616 GN=TRMT2A PE=3 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.7 0.0 0.98 2.1e+03 60 90 .. 117 149 .. 114 150 .. 0.86 2 ! 24.9 0.1 6.4e-09 1.4e-05 4 70 .. 447 511 .. 444 521 .. 0.82 Alignments for each domain: == domain 1 score: -1.7 bits; conditional E-value: 0.98 CCCHHHHCS-TTSEEEEEEES-..----SGGGG CS Methyltransf_4 60 alkvllelledgslekifilFP..DPwfKkrhh 90 a+kvl+ +l +g++ i++ P DP Kkr++ tr|F6S9Y2|F6S9Y2_MONDO 117 AMKVLHGALWKGRCLSIRLAKPkaDPMAKKRKR 149 899999999999999999998877999999985 PP == domain 2 score: 24.9 bits; conditional E-value: 6.4e-09 EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-T CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelled 70 +vl+++cG G++ + lA+ k ++GiE+ ++ v+ + +++ + l N++ ++g a +++++l++ tr|F6S9Y2|F6S9Y2_MONDO 447 TVLDVCCGTGTIGLSLAQ--TVKRVIGIELCQEAVEDARVNAKMNALDNIEFHCGKAEDLVPSLMSS 511 799*******98777776..5799*********************************7776666554 PP >> tr|F7D1V9|F7D1V9_MONDO Uncharacterized protein OS=Monodelphis domestica OX=13616 GN=METTL26 PE=4 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.5 0.0 6.9e-08 0.00015 4 54 .. 28 78 .. 25 86 .. 0.94 Alignments for each domain: == domain 1 score: 21.5 bits; conditional E-value: 6.9e-08 EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 vle+ +G+G+++ Ak++P++ + E+ ++ ++ + + i++++l+N+r tr|F7D1V9|F7D1V9_MONDO 28 QVLEVASGSGQHVTYFAKAFPKVVWQPTEVDRQCLNSISALIKKEQLQNVR 78 689**********************************************97 PP >> tr|F6ZXU0|F6ZXU0_MONDO Methyltransferase like 5 OS=Monodelphis domestica OX=13616 GN=METTL5 PE=4 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 17.2 0.1 1.5e-06 0.0032 2 79 .. 49 123 .. 48 133 .. 0.85 Alignments for each domain: == domain 1 score: 17.2 bits; conditional E-value: 1.5e-06 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-TTSEEEEEEE CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelledgslekifil 79 ++v+ ++GcG G + + A +++G +i ++ ++ +k++++ el+N+ +++ + l+e +++ s++ i ++ tr|F6ZXU0|F6ZXU0_MONDO 49 NKVIGDLGCGCGMLSIGAAML-GAGLCVGFDIDEDALEIFNKNVKEFELTNIDMIQCNV-CSLSETISK-SFDTIIMN 123 577889******999987765.5679********************************6.899999998.88888886 PP >> tr|F6ZAN7|F6ZAN7_MONDO Glutathione S-transferase C-terminal domain containing OS=Monodelphis domestica OX=13616 GN=G # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 16.4 0.0 2.6e-06 0.0054 4 66 .. 432 493 .. 429 498 .. 0.92 Alignments for each domain: == domain 1 score: 16.4 bits; conditional E-value: 2.6e-06 EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHH CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvlle 66 ++++ ++G G++ + lA+ P++++l iE ++ ++ ++ k+ ++l+l+N+ ++ + l++++ tr|F6ZAN7|F6ZAN7_MONDO 432 IIVDFCSGGGHVGIVLAHLLPSCQVLLIENKELSLVRAKKRSDDLGLTNIWFIQAN-LDYFTG 493 799***************************************************99.477765 PP >> tr|F6Z8P9|F6Z8P9_MONDO Exportin 4 OS=Monodelphis domestica OX=13616 GN=XPO4 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.4 0.0 0.00019 0.39 94 151 .. 746 811 .. 687 824 .. 0.69 2 ? 1.5 0.1 0.099 2.1e+02 17 57 .. 846 886 .. 841 901 .. 0.86 Alignments for each domain: == domain 1 score: 10.4 bits; conditional E-value: 0.00019 TTSHHHHHHHHHHEEEEEEEEEEES.........HHHHHHHHHHHHHCSTTEEESSCCCSCCTCHCH CS Methyltransf_4 94 llqpellkelarvLkkgGvlelaTD.........veeyaeemlkvleeeplferlskeeeleeepls 151 ll++ + l+++L+ gG+ ++ TD +++++++ l+v+++e +f+++++eee+++e++ tr|F6Z8P9|F6Z8P9_MONDO 746 LLSSSVQRTLMKALVLGGFAHMDTDtkqqywtevLQPLQQRFLNVINQE-NFQQICQEEEVKQEITA 811 6677777889***************977776555556666666666666.78888887777776665 PP == domain 2 score: 1.5 bits; conditional E-value: 0.099 HHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEE CS Methyltransf_4 17 valAkknPdknflGiEirvkvvakvlkkiealelkNlrilr 57 ++ k+ P++ l iE+ v+v +k ++ +++++ Nl+ + tr|F6Z8P9|F6Z8P9_MONDO 846 MEVYKNTPETVNLIIEVFVEVAHKQICYLGESKAMNLYEAC 886 6677899*****************************98666 PP >> tr|F6SAW9|F6SAW9_MONDO EEF1A lysine methyltransferase 2 OS=Monodelphis domestica OX=13616 GN=EEF1AKMT2 PE=3 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 13.4 0.0 2.2e-05 0.047 4 60 .. 65 120 .. 63 175 .. 0.79 Alignments for each domain: == domain 1 score: 13.4 bits; conditional E-value: 2.2e-05 EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-C CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgda 60 vl+iG+G+G flv+lAk ++ Gi+ ++ + ie+++++N+ l+ + tr|F6SAW9|F6SAW9_MONDO 65 SVLDIGTGNGIFLVELAKLG-YSDITGIDYCPLAIQLSGRIIEKEGFSNIIKLQVED 120 689**************975.567889999999999999999999999998887764 PP >> tr|F7B9I4|F7B9I4_MONDO HemK methyltransferase family member 1 OS=Monodelphis domestica OX=13616 GN=HEMK1 PE=4 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.5 0.0 8.6e-05 0.18 3 60 .. 172 230 .. 170 238 .. 0.90 2 ? -1.6 0.0 0.92 2e+03 98 127 .. 288 319 .. 285 325 .. 0.81 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 8.6e-05 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSS.EEEEES-C CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkN.lrilrgda 60 p++l+++cG+G + + l k + ++++++ ++ v+ +++++l+l+ ++i+r+d tr|F7B9I4|F7B9I4_MONDO 172 PLILDVCCGSGAIALSLLSKLTQSRVVAVDKGEEAVQLTRENAQRLHLEDrIQIVRHDI 230 799***********************************999999998874488888886 PP == domain 2 score: -1.6 bits; conditional E-value: 0.92 HHHHHHHHHEEEEEEEEEEES..HHHHHHHHH CS Methyltransf_4 98 ellkelarvLkkgGvlelaTD..veeyaeeml 127 e+l+++ Lk +G++ l D ++e+ e+ l tr|F7B9I4|F7B9I4_MONDO 288 EILSQAPMLLKDSGSIFLEVDprHPELVEKWL 319 678888899*********99988888777665 PP >> tr|F7FNT7|F7FNT7_MONDO NOP2/Sun RNA methyltransferase family member 6 OS=Monodelphis domestica OX=13616 GN=NSUN6 PE= # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 7.4 0.1 0.0016 3.4 5 65 .. 238 299 .. 235 305 .. 0.85 2 ? 1.1 0.0 0.13 2.7e+02 96 137 .. 349 390 .. 348 402 .. 0.72 Alignments for each domain: == domain 1 score: 7.4 bits; conditional E-value: 0.0016 EEEET-TTSHHHHHHHH.HSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHH CS Methyltransf_4 5 vleiGcGkGeflvalAk.knPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvll 65 +l+++ + G+ + ++A ++ + +++++++ + v+k+ ++++ l+l+ +r ++ + +k l tr|F7FNT7|F7FNT7_MONDO 238 ILDMCAAPGGKTTHIAAlMRDQGEVIAMDKIPSKVEKIKQNAALLQLNCIRAFCCNGTKALG 299 688999999888888761556679********************************999884 PP == domain 2 score: 1.1 bits; conditional E-value: 0.13 SHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTTEE CS Methyltransf_4 96 qpellkelarvLkkgGvlelaTDveeyaeemlkvleeeplfe 137 q++l + + + Lk+gGvl+ T +ae+ +v+ + + f tr|F7FNT7|F7FNT7_MONDO 349 QRKLFTVAVQLLKPGGVLVYSTCTITLAENEEQVAWALTAFP 390 6778888899**********9997777777666655555554 PP >> tr|F6R6T5|F6R6T5_MONDO Methylphosphate capping enzyme OS=Monodelphis domestica OX=13616 GN=MEPCE PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 9.6 0.0 0.00032 0.68 4 54 .. 434 484 .. 431 489 .. 0.88 Alignments for each domain: == domain 1 score: 9.6 bits; conditional E-value: 0.00032 EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 vl++Gc G++++ +A k ++G++i ++++ + ++i+++ + lr tr|F6R6T5|F6R6T5_MONDO 434 DVLDLGCNVGHLTLSIACKWGPARVVGVDIDARLIHSARQNIRHYLSEELR 484 689*************************************99988666555 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (173 nodes) Target sequences: 21272 (11266248 residues searched) Passed MSV filter: 829 (0.0389714); expected 425.4 (0.02) Passed bias filter: 481 (0.0226119); expected 425.4 (0.02) Passed Vit filter: 55 (0.00258556); expected 21.3 (0.001) Passed Fwd filter: 10 (0.000470102); expected 0.2 (1e-05) Initial search space (Z): 21272 [actual number of targets] Domain search space (domZ): 10 [number of targets reported over threshold] # CPU time: 0.17u 0.01s 00:00:00.18 Elapsed: 00:00:00.07 # Mc/sec: 27843.73 // [ok]