# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_4.hmm.txt
# target sequence database: proteomes/Mus_musculus.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_4 [M=173]
Accession: PF02390.16
Description: Putative methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
1.1e-60 204.4 0.0 1.4e-60 204.0 0.0 1.1 1 sp|Q9Z120|TRMB_MOUSE tRNA (guanine-N(7)-)-methyltransferase
8.3e-05 22.4 0.0 0.00024 20.9 0.0 1.7 2 sp|Q921L7|HEMK1_MOUSE HemK methyltransferase family member 1
0.00065 19.5 0.0 0.0014 18.4 0.0 1.5 1 sp|Q8BQJ6|TRM2_MOUSE tRNA (uracil(54)-C(5))-methyltransfera
0.0037 17.1 0.1 0.0056 16.5 0.1 1.2 1 sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=Mu
0.0079 16.0 0.0 0.013 15.3 0.0 1.2 1 sp|Q9DCS2|MTL26_MOUSE Methyltransferase-like 26 OS=Mus muscu
0.0095 15.7 0.0 0.018 14.8 0.0 1.4 1 sp|Q5RL51|GSTCD_MOUSE Glutathione S-transferase C-terminal d
0.0097 15.7 0.0 0.013 15.3 0.0 1.3 1 sp|Q9D853|EFMT2_MOUSE EEF1A lysine methyltransferase 2 OS=Mu
------ inclusion threshold ------
0.059 13.1 0.0 1.9 8.2 0.0 2.3 2 sp|Q7TS68|NSUN6_MOUSE Putative methyltransferase NSUN6 OS=Mu
0.098 12.4 0.0 0.17 11.6 0.0 1.4 1 sp|Q6PAK3|ANM8_MOUSE Protein arginine N-methyltransferase 8
0.14 11.9 0.0 0.25 11.1 0.0 1.3 1 sp|Q3UY23|FDXA1_MOUSE Ferredoxin-fold anticodon-binding doma
0.18 11.6 0.1 0.35 10.6 0.1 1.4 1 sp|Q8BNV1|TRM2A_MOUSE tRNA (uracil-5-)-methyltransferase hom
Domain annotation for each sequence (and alignments):
>> sp|Q9Z120|TRMB_MOUSE tRNA (guanine-N(7)-)-methyltransferase OS=Mus musculus OX=10090 GN=Mettl1 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 204.0 0.0 6.8e-64 1.4e-60 2 172 .. 71 247 .. 70 248 .. 0.98
Alignments for each domain:
== domain 1 score: 204.0 bits; conditional E-value: 6.8e-64
-EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC......TTSSEEEEES-CCCHHHHCS-TTSEEEEEEES---- CS
Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal......elkNlrilrgdalkvllelledgslekifilFPDPw 84
++ +++iGcG+G++lval++ +Pd+++lG+Eirvkv+++v ++i+al +++N+++lr++a+k+l++++++g+l+k+f+lFPDP+
sp|Q9Z120|TRMB_MOUSE 71 QVEFADIGCGYGGLLVALSPLFPDTLILGLEIRVKVSDYVQDRIRALraapggGFQNIACLRSNAMKHLPNFFRKGQLAKMFFLFPDPH 159
6789************************************************************************************* PP
-SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTTEEESSCCCSCCTCHCHHCCCSSTTCCCCCCTTSS-EE CS
Methyltransf_4 85 fKkrhhKrRllqpellkelarvLkkgGvlelaTDveeyaeemlkvleeeplferlskeeeleeeplsvlriatkyeqkvqskgkeiye 172
fK+ +hK+R+++p+ll+e+a+vL++gG+++++TDv+e++e+m++++ee+plfer+ ee e++++++l +t++++kv ++g++ +
sp|Q9Z120|TRMB_MOUSE 160 FKRTKHKWRIISPTLLAEYAYVLRVGGLVYTVTDVPELHEWMCTHFEEHPLFERVPLEELSEDPIVEHLGSSTEEGKKVLRNGGKNFP 247
***********************************************************************************99886 PP
>> sp|Q921L7|HEMK1_MOUSE HemK methyltransferase family member 1 OS=Mus musculus OX=10090 GN=Hemk1 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 20.9 0.0 1.2e-07 0.00024 2 60 .. 161 220 .. 160 231 .. 0.90
2 ? -2.5 0.0 1.9 3.9e+03 98 124 .. 278 306 .. 276 326 .. 0.69
Alignments for each domain:
== domain 1 score: 20.9 bits; conditional E-value: 1.2e-07
-EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSS.EEEEES-C CS
Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkN.lrilrgda 60
p++le+GcG+G +++ l + P+ ++++++++ v +++++l+l+ +ri++ d
sp|Q921L7|HEMK1_MOUSE 161 GPLILEVGCGSGAITLSLLSQLPKSRVVAVDKEEAAVSLTHENAQRLQLQDrIRIIHLDI 220
689*******************************************99885477777765 PP
== domain 2 score: -2.5 bits; conditional E-value: 1.9
HHHHHHHHHEEEEEEEEEEES..HHHHHH CS
Methyltransf_4 98 ellkelarvLkkgGvlelaTD..veeyae 124
++l+ + + L+ +G++ l D ++e+
sp|Q921L7|HEMK1_MOUSE 278 HILTLAPQLLNASGSIFLEVDprHPELVS 306
56777888999999999999977555443 PP
>> sp|Q8BQJ6|TRM2_MOUSE tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Mus musculus OX=10090 GN=Trmt2b PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.4 0.0 7e-07 0.0014 2 78 .. 334 408 .. 333 415 .. 0.89
Alignments for each domain:
== domain 1 score: 18.4 bits; conditional E-value: 7e-07
-EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-TTSEEEEEE CS
Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelledgslekifi 78
++++l+i+cG G + + A++ + + GiE+ ++ v+ + +++ ++++N + + g a ++l++ll+ ++ ek+ +
sp|Q8BQJ6|TRM2_MOUSE 334 ESLLLDICCGTGVIGLSVAQRASQ--VHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILPQLLKSQKDEKLTV 408
5789********988888888765..66****************************************999888776 PP
>> sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=Mus musculus OX=10090 GN=Mettl5 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 16.5 0.1 2.7e-06 0.0056 2 70 .. 52 118 .. 51 128 .. 0.86
Alignments for each domain:
== domain 1 score: 16.5 bits; conditional E-value: 2.7e-06
-EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-T CS
Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelled 70
++ v+++GcG G + + A +++G +i ++ ++ +k++e+ el+N+ +++ d + l++ +++
sp|Q8K1A0|METL5_MOUSE 52 NKAVADLGCGCGVLSIGAAML-GAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDV-YSLSNRMSK 118
57899*******999987765.5679********************************6.888888876 PP
>> sp|Q9DCS2|MTL26_MOUSE Methyltransferase-like 26 OS=Mus musculus OX=10090 GN=Mettl26 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 15.3 0.0 6.2e-06 0.013 4 54 .. 30 80 .. 27 83 .. 0.95
Alignments for each domain:
== domain 1 score: 15.3 bits; conditional E-value: 6.2e-06
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54
vle+ +G+G++ + A+++P+ ++ ++ ++ ++ + ++ +a++l+N++
sp|Q9DCS2|MTL26_MOUSE 30 RVLEVASGSGQHAAHFAQAFPNAEWQPSDVDQRCLDSIAATTRAQGLSNVK 80
589**********************************************97 PP
>> sp|Q5RL51|GSTCD_MOUSE Glutathione S-transferase C-terminal domain-containing protein OS=Mus musculus OX=10090 GN=Gst
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.8 0.0 8.9e-06 0.018 5 69 .. 446 509 .. 443 512 .. 0.95
Alignments for each domain:
== domain 1 score: 14.8 bits; conditional E-value: 8.9e-06
EEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS- CS
Methyltransf_4 5 vleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelle 69
+++ ++G G++ + lA++ P++++ iE ++ ++ ++ k+ ++l+l+N+ ++ + +++++ +++
sp|Q5RL51|GSTCD_MOUSE 446 IVDFCSGGGHVGIVLAHMLPSCQVTLIENKELSLIRAKKRSDELGLSNIWFIQAN-MEYFTGMFN 509
699****************************************************.799998885 PP
>> sp|Q9D853|EFMT2_MOUSE EEF1A lysine methyltransferase 2 OS=Mus musculus OX=10090 GN=Eef1akmt2 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 15.3 0.0 6.4e-06 0.013 4 60 .. 82 137 .. 80 191 .. 0.85
Alignments for each domain:
== domain 1 score: 15.3 bits; conditional E-value: 6.4e-06
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-C CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgda 60
vl+iG+G+G flv+l k+ n+ Gi+ + + ++ + e+++l+N+++ d
sp|Q9D853|EFMT2_MOUSE 82 SVLDIGTGNGVFLVELVKH-GFSNITGIDYSPSAIKLSASILEKEGLSNINLKVEDF 137
689*************986.56799*************************9987775 PP
>> sp|Q7TS68|NSUN6_MOUSE Putative methyltransferase NSUN6 OS=Mus musculus OX=10090 GN=Nsun6 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 8.2 0.0 0.00096 1.9 5 65 .. 238 299 .. 235 306 .. 0.83
2 ? 2.3 0.0 0.061 1.2e+02 96 135 .. 351 390 .. 349 403 .. 0.76
Alignments for each domain:
== domain 1 score: 8.2 bits; conditional E-value: 0.00096
EEEET-TTSHHH.HHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHH CS
Methyltransf_4 5 vleiGcGkGefl.valAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvll 65
+l+++ + G+ + + A ++ + +++++++ + v+k+ +++ l+l+ +r ++ da+k l+
sp|Q7TS68|NSUN6_MOUSE 238 ILDMCAAPGGKTtHTAALMQDKGEVIALDKILTKVNKLKQNASLLGLHSIRAFCFDATKALK 299
577787776555055667788889*********************************99986 PP
== domain 2 score: 2.3 bits; conditional E-value: 0.061
SHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTT CS
Methyltransf_4 96 qpellkelarvLkkgGvlelaTDveeyaeemlkvleeepl 135
q++ll+ + + Lk+gGvl+ T +ae+ +v+ + +
sp|Q7TS68|NSUN6_MOUSE 351 QRKLLHVAVQLLKPGGVLVYSTCTITLAENEEQVAWALRT 390
88999999************99887777776665555554 PP
>> sp|Q6PAK3|ANM8_MOUSE Protein arginine N-methyltransferase 8 OS=Mus musculus OX=10090 GN=Prmt8 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.6 0.0 8.6e-05 0.17 2 57 .. 112 165 .. 111 177 .. 0.82
Alignments for each domain:
== domain 1 score: 11.6 bits; conditional E-value: 8.6e-05
-EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEE CS
Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilr 57
+vvl++G+G G + + A k k+++GiE + +++++ k i+a++l N+ ++
sp|Q6PAK3|ANM8_MOUSE 112 DKVVLDVGSGTGIL-SMFAAKAGAKKVFGIECS-SISDYSEKIIKANHLDNVITIF 165
5799*******965.5566677778899***96.5789999999999****97765 PP
>> sp|Q3UY23|FDXA1_MOUSE Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog OS=Mus musculus OX=10090
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.1 0.0 0.00012 0.25 62 115 .. 68 123 .. 42 124 .. 0.84
Alignments for each domain:
== domain 1 score: 11.1 bits; conditional E-value: 0.00012
CHHHHCS-..TTSEEEEEEES-----SGGGGGGSTTSHHHHHHHHHHEEEEEEEEE CS
Methyltransf_4 62 kvllelle..dgslekifilFPDPwfKkrhhKrRllqpellkelarvLkkgGvlel 115
++l+++l+ d+ +++i+++FP K+ K R l ++ + a+vL k G++++
sp|Q3UY23|FDXA1_MOUSE 68 TQLSHALPadDRDFDRIYFNFPHCGRKAGVAKNRELLAKFFQSCADVLAKAGEVHV 123
66677765336789****************************************96 PP
>> sp|Q8BNV1|TRM2A_MOUSE tRNA (uracil-5-)-methyltransferase homolog A OS=Mus musculus OX=10090 GN=Trmt2a PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.6 0.1 0.00017 0.35 4 45 .. 425 464 .. 423 489 .. 0.79
Alignments for each domain:
== domain 1 score: 10.6 bits; conditional E-value: 0.00017
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHH CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkki 45
+vl+++cG G++ +alA+k k ++GiE+ ++ v+ + ++
sp|Q8BNV1|TRM2A_MOUSE 425 TVLDVCCGTGTIGLALAPKV--KRVVGIELCQEAVEDARMNA 464
799********999999885..889*******9999875544 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (173 nodes)
Target sequences: 22289 (11757923 residues searched)
Passed MSV filter: 698 (0.0313159); expected 445.8 (0.02)
Passed bias filter: 487 (0.0218493); expected 445.8 (0.02)
Passed Vit filter: 54 (0.00242272); expected 22.3 (0.001)
Passed Fwd filter: 11 (0.000493517); expected 0.2 (1e-05)
Initial search space (Z): 22289 [actual number of targets]
Domain search space (domZ): 11 [number of targets reported over threshold]
# CPU time: 0.16u 0.01s 00:00:00.17 Elapsed: 00:00:00.08
# Mc/sec: 25426.51
//
[ok]