# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_4.hmm.txt
# target sequence database: proteomes/Thermococcus_kodakarensis.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_4 [M=173]
Accession: PF02390.16
Description: Putative methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
1.3e-06 25.1 0.1 4.4e-06 23.4 0.1 1.8 2 tr|Q5JFS6|Q5JFS6_THEKO Predicted SAM-dependent methyltransfe
3.4e-05 20.5 0.1 0.00032 17.3 0.0 2.1 2 tr|Q5JEW7|Q5JEW7_THEKO tRNA/rRNA cytosine-C5-methylase, NOL1
0.00025 17.6 0.0 0.00066 16.3 0.0 1.7 1 tr|Q5JEM0|Q5JEM0_THEKO Predicted N6-adenine-specific DNA met
0.00053 16.6 0.0 0.00078 16.1 0.0 1.2 1 tr|Q5JEE1|Q5JEE1_THEKO Protein-L-isoaspartate O-methyltransf
0.00072 16.2 0.0 0.0016 15.0 0.0 1.6 2 tr|Q5JGN8|Q5JGN8_THEKO SAM-dependent methyltransferase, UbiE
0.0034 14.0 0.0 0.012 12.2 0.0 1.7 2 tr|Q5JJ79|Q5JJ79_THEKO Predicted SAM-dependent methyltransfe
Domain annotation for each sequence (and alignments):
>> tr|Q5JFS6|Q5JFS6_THEKO Predicted SAM-dependent methyltransferase OS=Thermococcus kodakarensis (strain ATCC BAA-918 /
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 23.4 0.1 1.1e-08 4.4e-06 5 63 .. 61 118 .. 58 145 .. 0.81
2 ? -0.5 0.0 0.24 92 98 127 .. 140 170 .. 136 182 .. 0.74
Alignments for each domain:
== domain 1 score: 23.4 bits; conditional E-value: 1.1e-08
EEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCH CS
Methyltransf_4 5 vleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkv 63
vl++GcG G ++ ++A kn ++G++ +++v++ + ++ +++ kN + ++g+ l++
tr|Q5JFS6|Q5JFS6_THEKO 61 VLDVGCGTGVLTFKMALKNGVEMVVGVDRKEEVIEFC-NRLGDRVTKNAKFVQGNFLEM 118
79**************************999999766.567778899999999996543 PP
== domain 2 score: -0.5 bits; conditional E-value: 0.24
HHHHHHHHHEEEEEEEEE.EESHHHHHHHHH CS
Methyltransf_4 98 ellkelarvLkkgGvlel.aTDveeyaeeml 127
+l+ + +vL++gG + + D++++ +++
tr|Q5JFS6|Q5JFS6_THEKO 140 PFLERALEVLEEGGRVIVgDFDINDLRKRIR 170
68999999******87551456666666655 PP
>> tr|Q5JEW7|Q5JEW7_THEKO tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, containing RNA-binding PUA domain OS=T
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.3 0.0 8.3e-07 0.00032 4 65 .. 201 262 .. 198 269 .. 0.86
2 ? 0.6 0.0 0.11 43 96 128 .. 302 334 .. 300 350 .. 0.81
Alignments for each domain:
== domain 1 score: 17.3 bits; conditional E-value: 8.3e-07
EEEEET-TTSHHHHHHHH.HSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHH CS
Methyltransf_4 4 vvleiGcGkGeflvalAk.knPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvll 65
+++++ + G+ ++++A+ ++ ++++i++++++++k+ ++ ++l++kN+r+++ da + l+
tr|Q5JEW7|Q5JEW7_THEKO 201 LIIDMAAAPGGKTSHIAQlMQNRGEIIAIDKSRNRLRKMEEELKRLGVKNVRLIHMDA-RKLP 262
6788888889999999984567789********************************9.5555 PP
== domain 2 score: 0.6 bits; conditional E-value: 0.11
SHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHH CS
Methyltransf_4 96 qpellkelarvLkkgGvlelaTDveeyaeemlk 128
q++++ ++ + L+kgG l+ T y e+ ++
tr|Q5JEW7|Q5JEW7_THEKO 302 QRAFIWAAIKSLRKGGTLVYSTCTISYEENEAN 334
6778888999**********9998888877554 PP
>> tr|Q5JEM0|Q5JEM0_THEKO Predicted N6-adenine-specific DNA methylase OS=Thermococcus kodakarensis (strain ATCC BAA-918
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 16.3 0.0 1.7e-06 0.00066 6 70 .. 222 286 .. 218 331 .. 0.86
Alignments for each domain:
== domain 1 score: 16.3 bits; conditional E-value: 1.7e-06
EEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHH.HHHHHCTTSSEEEEES-CCCHHHHCS-T CS
Methyltransf_4 6 leiGcGkGeflvalAkknPdknflGiEirvkvvakvl.kkiealelkNlrilrgdalkvllelled 70
++ cG+G++l++lA + + ++G+E+++k ++ + ++ a l ++ ++gda + l++++e
tr|Q5JEM0|Q5JEM0_THEKO 222 IDPFCGSGTILIELALRGYKGRIIGLEKYRKHIRGAEmNALSAGVLDKIEFIQGDA-TKLSQYVES 286
5556*****************************998614555668999********.889999876 PP
>> tr|Q5JEE1|Q5JEE1_THEKO Protein-L-isoaspartate O-methyltransferase OS=Thermococcus kodakarensis (strain ATCC BAA-918
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 16.1 0.0 2e-06 0.00078 4 64 .. 80 139 .. 77 148 .. 0.87
Alignments for each domain:
== domain 1 score: 16.1 bits; conditional E-value: 2e-06
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHH CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvl 64
vleiG+G+G+ + + ++++ iE ++v+ + ++ e+ ++kN++++ gd +k +
tr|Q5JEE1|Q5JEE1_THEKO 80 NVLEIGTGSGWNAALI-SELVKTDVYTIERIPELVEFARRNLERAGVKNVHVILGDGTKGF 139
589*******876555.567899999******************************97765 PP
>> tr|Q5JGN8|Q5JGN8_THEKO SAM-dependent methyltransferase, UbiE/COQ5 family OS=Thermococcus kodakarensis (strain ATCC B
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 15.0 0.0 4.2e-06 0.0016 4 80 .. 44 113 .. 41 115 .. 0.82
2 ? -3.6 0.0 2.2 8.3e+02 98 113 .. 126 141 .. 125 143 .. 0.81
Alignments for each domain:
== domain 1 score: 15.0 bits; conditional E-value: 4.2e-06
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-TTSEEEEEEES CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelledgslekifilF 80
vl++ cG G +++lA++ ++lG+++++++++ + +k+ea++l N++ +rg+al+ ++e+ +++ + ++F
tr|Q5JGN8|Q5JGN8_THEKO 44 RVLDLACGTGIPTLELAERG--YEVLGLDLHEEMLRVARRKAEARGL-NVKFIRGNALD---ISFEE-EFDAVTMFF 113
589**************986..678*********9999999888776.9********54...45555.677777776 PP
== domain 2 score: -3.6 bits; conditional E-value: 2.2
HHHHHHHHHEEEEEEE CS
Methyltransf_4 98 ellkelarvLkkgGvl 113
el + + r+L++gGv+
tr|Q5JGN8|Q5JGN8_THEKO 126 ELFNSVRRTLRPGGVF 141
567889999****986 PP
>> tr|Q5JJ79|Q5JJ79_THEKO Predicted SAM-dependent methyltransferase, DUF890 family OS=Thermococcus kodakarensis (strain
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 12.2 0.0 3.2e-05 0.012 5 71 .. 85 149 .. 82 162 .. 0.85
2 ? -1.1 0.0 0.37 1.4e+02 98 132 .. 188 223 .. 185 230 .. 0.75
Alignments for each domain:
== domain 1 score: 12.2 bits; conditional E-value: 3.2e-05
EEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-TT CS
Methyltransf_4 5 vleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelledg 71
vleiG+G ++ +A++ ++++ + E+ ++ +++ ++ie+++ N++ ++++ +++ ++++g
tr|Q5JJ79|Q5JJ79_THEKO 85 VLEIGTGHTAMMALMAERLFNCDVTATELDEEFFEYAKRNIEKNG-ANVKPIKSNG-GIIRGVVPKG 149
89***********************************99998765.6999999997.7777777765 PP
== domain 2 score: -1.1 bits; conditional E-value: 0.37
HHHHHHHHHEEEEEEEEE.EESHHHHHHHHHHHHHC CS
Methyltransf_4 98 ellkelarvLkkgGvlel.aTDveeyaeemlkvlee 132
l++e+ + L++gG + l D e++ e ++++ +e
tr|Q5JJ79|Q5JJ79_THEKO 188 RLIEEALEYLNPGGKVALfLPDKEPLIEAIAEKGKE 223
678899999999999975157888888887777655 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (173 nodes)
Target sequences: 2301 (637680 residues searched)
Passed MSV filter: 88 (0.0382442); expected 46.0 (0.02)
Passed bias filter: 75 (0.0325945); expected 46.0 (0.02)
Passed Vit filter: 17 (0.00738809); expected 2.3 (0.001)
Passed Fwd filter: 6 (0.00260756); expected 0.0 (1e-05)
Initial search space (Z): 2301 [actual number of targets]
Domain search space (domZ): 6 [number of targets reported over threshold]
# CPU time: 0.02u 0.00s 00:00:00.02 Elapsed: 00:00:00.01
# Mc/sec: 11031.86
//
[ok]