# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_4.hmm.txt # target sequence database: proteomes/Trichoplax_adhaerens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_4 [M=173] Accession: PF02390.16 Description: Putative methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 2e-49 166.8 0.0 2.4e-49 166.5 0.0 1.1 1 tr|B3RL30|B3RL30_TRIAD tRNA (guanine-N(7)-)-methyltransferas 1.1e-07 30.8 0.1 1.1e-07 30.8 0.1 1.7 2 tr|B3S5B9|B3S5B9_TRIAD Uncharacterized protein OS=Trichoplax 3.5e-05 22.7 0.5 9.9e-05 21.2 0.0 2.0 2 tr|B3RLM9|B3RLM9_TRIAD Uncharacterized protein OS=Trichoplax 0.00024 20.0 0.0 0.00036 19.4 0.0 1.3 1 tr|B3RQF2|B3RQF2_TRIAD Uncharacterized protein OS=Trichoplax 0.0019 17.1 0.1 0.0051 15.7 0.0 1.7 2 tr|B3RUJ8|B3RUJ8_TRIAD Uncharacterized protein OS=Trichoplax ------ inclusion threshold ------ 0.01 14.7 0.1 0.044 12.6 0.0 1.9 2 tr|B3RP82|B3RP82_TRIAD Uncharacterized protein OS=Trichoplax 0.026 13.4 0.0 0.042 12.7 0.0 1.3 1 tr|B3RN34|B3RN34_TRIAD Uncharacterized protein OS=Trichoplax 0.03 13.2 0.0 0.052 12.4 0.0 1.4 1 tr|B3S4V8|B3S4V8_TRIAD rRNA adenine N(6)-methyltransferase O 0.043 12.7 0.0 0.068 12.0 0.0 1.3 1 tr|B3S3V1|B3S3V1_TRIAD Uncharacterized protein OS=Trichoplax 0.045 12.6 4.4 1.5 7.7 0.0 2.8 2 tr|B3S2J9|B3S2J9_TRIAD Histone-lysine N-methyltransferase, H Domain annotation for each sequence (and alignments): >> tr|B3RL30|B3RL30_TRIAD tRNA (guanine-N(7)-)-methyltransferase OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_18672 P # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 166.5 0.0 2.1e-52 2.4e-49 3 172 .. 47 218 .. 45 219 .. 0.97 Alignments for each domain: == domain 1 score: 166.5 bits; conditional E-value: 2.1e-52 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC......TTSSEEEEES-CCCHHHHCS-TTSEEEEEEES--- CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal......elkNlrilrgdalkvllelledgslekifilFPDP 83 + +l+iGcG+G++l++lA+ +Pd+ ++G+Eirvkv+++v ++i+al +++N++i+r++a+k+l++++++g+l+k+f+l+PDP tr|B3RL30|B3RL30_TRIAD 47 VQFLDIGCGYGGLLITLAPLFPDTYIMGMEIRVKVSDYVKERIAALrinnpgKYNNIAIVRTNAMKYLPNYFKKGQLKKLFFLYPDP 133 579************************************************************************************ PP --SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTTEEESSCCCSCCTCHCHHCCCSSTTCCCCCCTTSS- CS Methyltransf_4 84 wfKkrhhKrRllqpellkelarvLkkgGvlelaTDveeyaeemlkvleeeplferlskeeeleeeplsvlriatkyeqkvqskgkei 170 +fKk +hK+R+l + ++++ L+ +G+++++TDvee++ +m ++l+e+plfe ++ e+ ++ +l+ l t+++qkv+++++++ tr|B3RL30|B3RL30_TRIAD 134 HFKKTKHKQRILRH----DIEYLLQLRGLVYTVTDVEEVHIWMKSHLNEHPLFEEVKLESLSHDAILKFLGDCTEEGQKVTRNDGKK 216 ***********985....799***************************************************************998 PP EE CS Methyltransf_4 171 ye 172 + tr|B3RL30|B3RL30_TRIAD 217 FT 218 86 PP >> tr|B3S5B9|B3S5B9_TRIAD Uncharacterized protein OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_59271 PE=3 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -3.7 0.2 3.9 4.5e+03 140 161 .. 22 43 .. 13 46 .. 0.68 2 ! 30.8 0.1 9.6e-11 1.1e-07 3 79 .. 401 475 .. 399 502 .. 0.86 Alignments for each domain: == domain 1 score: -3.7 bits; conditional E-value: 3.9 SCCCSCCTCHCHHCCCSSTTCC CS Methyltransf_4 140 skeeeleeeplsvlriatkyeq 161 +++++ +++ ++ ++ tk+e+ tr|B3S5B9|B3S5B9_TRIAD 22 EQNQMHSDQEQHDHYSYTKREE 43 4556666677777888888875 PP == domain 2 score: 30.8 bits; conditional E-value: 9.6e-11 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS-TTSEEEEEEE CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelledgslekifil 79 vvl+i+cG G++ + +Ak+ + ++GiE+ ++ ++ + ++e +++kN++ ++g a + l++l+ + s+ +i tr|B3S5B9|B3S5B9_TRIAD 401 TVVLDICCGTGTIGILMAKNV--NRVIGIEMVEDAIEDARVNAELNDIKNIEFICGKAEDKLPTLVDNLSVISEVIA 475 689***************986..679**************************************9998777555555 PP >> tr|B3RLM9|B3RLM9_TRIAD Uncharacterized protein OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_19869 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.7 0.2 0.96 1.1e+03 48 67 .. 33 52 .. 9 65 .. 0.50 2 ! 21.2 0.0 8.6e-08 9.9e-05 3 48 .. 95 140 .. 93 148 .. 0.89 Alignments for each domain: == domain 1 score: -1.7 bits; conditional E-value: 0.96 CTTSSEEEEES-CCCHHHHC CS Methyltransf_4 48 lelkNlrilrgdalkvllel 67 ++l+ l+ +r+d ++++++ tr|B3RLM9|B3RLM9_TRIAD 33 NDLQTLKKIRQDKVELVETT 52 24444555555555555444 PP == domain 2 score: 21.2 bits; conditional E-value: 8.6e-08 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal 48 + +l+iGc G++++++Akk+ ++++Gi+i +++ ++ ++i + tr|B3RLM9|B3RLM9_TRIAD 95 KDCLDIGCNDGHLTIEIAKKFNPNTIVGIDIDASLITRARSNITRI 140 679**********************************999998775 PP >> tr|B3RQF2|B3RQF2_TRIAD Uncharacterized protein OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_54966 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 19.4 0.0 3.1e-07 0.00036 2 62 .. 50 109 .. 49 126 .. 0.88 Alignments for each domain: == domain 1 score: 19.4 bits; conditional E-value: 3.1e-07 -EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCC CS Methyltransf_4 2 apvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalk 62 ++v+++GcG G + v A +++ +++Gi+i + + + ++ie+ el+N+++++ + + tr|B3RQF2|B3RQF2_TRIAD 50 GKLVCDLGCGCGVLSVGTAMLDAS-LIVGIDIDDDALMIARRNIEEFELENVQLIKANISD 109 5789****************9987.799*****************************9843 PP >> tr|B3RUJ8|B3RUJ8_TRIAD Uncharacterized protein OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_24037 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 15.7 0.0 4.4e-06 0.0051 3 39 .. 135 171 .. 133 198 .. 0.87 2 ? -2.4 0.0 1.5 1.8e+03 106 137 .. 259 292 .. 250 302 .. 0.69 Alignments for each domain: == domain 1 score: 15.7 bits; conditional E-value: 4.4e-06 EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHH CS Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvva 39 ++l+i+cG+G + + l +nP+ ++++i++ + + tr|B3RUJ8|B3RUJ8_TRIAD 135 ITFLDICCGSGAIGLSLLCENPQATCIAIDKDPNAIS 171 579***************************9988775 PP == domain 2 score: -2.4 bits; conditional E-value: 1.5 HEEEEEEEEEEES..HHHHHHHHHHHHHCSTTEE CS Methyltransf_4 106 vLkkgGvlelaTD..veeyaeemlkvleeeplfe 137 Lk +G + l D ++e+ e+ l+ + ++ tr|B3RUJ8|B3RUJ8_TRIAD 259 CLKDKGKIWLEVDinHPEMIEHYLNTHDTDFTYD 292 5888999999999666677777666666665555 PP >> tr|B3RP82|B3RP82_TRIAD Uncharacterized protein OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_53437 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.6 0.0 3.8e-05 0.044 5 51 .. 65 109 .. 62 116 .. 0.89 2 ? -1.3 0.0 0.7 8e+02 98 114 .. 148 164 .. 145 173 .. 0.83 Alignments for each domain: == domain 1 score: 12.6 bits; conditional E-value: 3.8e-05 EEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTS CS Methyltransf_4 5 vleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelk 51 +lei cG+G+ l +lA++ + Gi++++ ++a++ k ++++++ tr|B3RP82|B3RP82_TRIAD 65 LLEIACGSGNYLARLATQVD--KAYGIDMNQAMLAQCRTKLDQHQVQ 109 79**************9964..456****************999886 PP == domain 2 score: -1.3 bits; conditional E-value: 0.7 HHHHHHHHHEEEEEEEE CS Methyltransf_4 98 ellkelarvLkkgGvle 114 + e+ rvLk++G++ tr|B3RP82|B3RP82_TRIAD 148 DFFREINRVLKNNGMVI 164 6889999******9986 PP >> tr|B3RN34|B3RN34_TRIAD Uncharacterized protein OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_63612 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.7 0.0 3.6e-05 0.042 4 54 .. 31 81 .. 28 89 .. 0.94 Alignments for each domain: == domain 1 score: 12.7 bits; conditional E-value: 3.6e-05 EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEE CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlr 54 v+e+ +G G+++ Ak++ + + Ei+ + ++++ +++++++l+N++ tr|B3RN34|B3RN34_TRIAD 31 SVAEVASGHGQHICFFAKEFRQSVWSPTEINAEYLNRLTENVNREQLSNVK 81 689**********************************************97 PP >> tr|B3S4V8|B3S4V8_TRIAD rRNA adenine N(6)-methyltransferase OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_29342 PE=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.4 0.0 4.5e-05 0.052 4 62 .. 26 83 .. 23 91 .. 0.85 Alignments for each domain: == domain 1 score: 12.4 bits; conditional E-value: 4.5e-05 EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC.TTSSEEEEES-CCC CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal.elkNlrilrgdalk 62 +vleiG G G+++v+l +k k++++ E+ ++ a++ k+++ + + l+i+ gd lk tr|B3S4V8|B3S4V8_TRIAD 26 TVLEIGPGTGNLTVKLLQKA--KKVIACEVDPRLAAELQKRVQGSpVSTKLHIIVGDVLK 83 79**************8875..789*****************998555678888888765 PP >> tr|B3S3V1|B3S3V1_TRIAD Uncharacterized protein OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_28751 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.0 0.0 5.9e-05 0.068 6 72 .. 98 165 .. 93 178 .. 0.81 Alignments for each domain: == domain 1 score: 12.0 bits; conditional E-value: 5.9e-05 EEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTS.SEEEEES-CCCHHHHCS-TTS CS Methyltransf_4 6 leiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelk.Nlrilrgdalkvllelledgs 72 ++iG+G + + lA + +nfl+ E+ ++ v+++ k++ ++l ++i a+++l + l++++ tr|B3S3V1|B3S3V1_TRIAD 98 IDIGTGASCIYPLLAARMNGWNFLATEVDQRCVHYAQKNVTINDLDeKIKIKMVAAQDILCTPLRNEN 165 8*************************************998886641577777777777777666655 PP >> tr|B3S2J9|B3S2J9_TRIAD Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Trichoplax adhaerens OX=10228 GN # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 7.7 0.0 0.0013 1.5 4 34 .. 95 125 .. 92 140 .. 0.89 2 ? 2.7 3.3 0.041 48 91 168 .. 339 418 .. 334 423 .. 0.71 Alignments for each domain: == domain 1 score: 7.7 bits; conditional E-value: 0.0013 EEEEET-TTSHHHHHHHHHSTTSEEEEEES- CS Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEir 34 v++++G+G G+++++ A k++ GiE+ tr|B3S2J9|B3S2J9_TRIAD 95 VFIDLGSGVGQAVLQAAASTNCKECWGIEKA 125 89***************************75 PP == domain 2 score: 2.7 bits; conditional E-value: 0.041 GGSTTSHHHHHHHHHHEEEEEEEEEEES..HHHHHHHHHHHHHCSTTEEESSCCCSCCTC.HCHHCCCSSTTCCCCCCTTS CS Methyltransf_4 91 KrRllqpellkelarvLkkgGvlelaTD..veeyaeemlkvleeeplferlskeeeleee.plsvlriatkyeqkvqskgk 168 K+R q+ + + +Lk Gv + D +++ e+++k+l++++ ++ +ke++ + + +++ l + e+ ++++++ tr|B3S2J9|B3S2J9_TRIAD 339 KKRKKQHSQFSIMDAKLKA-GVASTDNDseYNNLNEKVIKKLKKHQGIKLKKKEKKIKSNsIKEALTSTADAEELINNQKN 418 6666677777777778875.5666666677899*************99988888776655055555555567776666655 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (173 nodes) Target sequences: 11518 (5222075 residues searched) Passed MSV filter: 470 (0.0408057); expected 230.4 (0.02) Passed bias filter: 299 (0.0259594); expected 230.4 (0.02) Passed Vit filter: 37 (0.00321236); expected 11.5 (0.001) Passed Fwd filter: 10 (0.000868206); expected 0.1 (1e-05) Initial search space (Z): 11518 [actual number of targets] Domain search space (domZ): 10 [number of targets reported over threshold] # CPU time: 0.08u 0.00s 00:00:00.08 Elapsed: 00:00:00.03 # Mc/sec: 30113.97 // [ok]