# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_4.hmm.txt
# target sequence database: proteomes/Trypanosoma_brucei.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_4 [M=173]
Accession: PF02390.16
Description: Putative methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
8.4e-37 125.2 0.0 1.1e-36 124.9 0.0 1.1 1 tr|Q38E77|Q38E77_TRYB2 tRNA (guanine-N(7)-)-methyltransferas
0.00017 20.1 0.0 0.00035 19.0 0.0 1.5 1 tr|Q4GYR8|Q4GYR8_TRYB2 Uncharacterized protein OS=Trypanosom
0.0021 16.5 0.0 0.0026 16.2 0.0 1.1 1 tr|Q4GYL1|Q4GYL1_TRYB2 Uncharacterized protein OS=Trypanosom
0.0038 15.7 0.0 0.0056 15.1 0.0 1.3 1 tr|Q57Z13|Q57Z13_TRYB2 Uncharacterized protein OS=Trypanosom
0.0072 14.8 0.0 0.017 13.6 0.0 1.6 2 tr|Q585P9|Q585P9_TRYB2 rRNA adenine N(6)-methyltransferase O
------ inclusion threshold ------
0.014 13.8 0.0 0.03 12.7 0.0 1.5 1 tr|Q389Z0|Q389Z0_TRYB2 Uncharacterized protein OS=Trypanosom
0.016 13.6 0.0 0.04 12.3 0.0 1.8 2 tr|Q386J1|Q386J1_TRYB2 Histone-lysine N-methyltransferase, H
0.02 13.4 0.0 0.039 12.4 0.0 1.5 1 tr|Q4GZF2|Q4GZF2_TRYB2 Histone-lysine N-methyltransferase, H
0.051 12.0 0.0 0.077 11.4 0.0 1.3 1 tr|Q581Z0|Q581Z0_TRYB2 Histone-lysine N-methyltransferase, H
Domain annotation for each sequence (and alignments):
>> tr|Q38E77|Q38E77_TRYB2 tRNA (guanine-N(7)-)-methyltransferase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 124.9 0.0 1.1e-39 1.1e-36 4 153 .. 54 214 .. 51 238 .. 0.90
Alignments for each domain:
== domain 1 score: 124.9 bits; conditional E-value: 1.1e-39
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC...........TTSSEEEEES-CCCHHHHCS-TTSEEEEEEE CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal...........elkNlrilrgdalkvllelledgslekifil 79
+++++Gc+ G++l lA+++Pd+ +lG+Eir kvv+ + +k+ +l +++N+ + + +k+ ++ +++g+l+ +f++
tr|Q38E77|Q38E77_TRYB2 54 TLVDVGCAFGGMLFSLAPDFPDMCMLGLEIRPKVVEFAQNKVMKLregaatdgtshHYRNVWFEQLNVMKFGSNCFNKGQLQALFFC 140
579************************************************************************************ PP
S-----SGGGGGGSTTSHHHHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTTEEESSCCCSCCTCHCHHC CS
Methyltransf_4 80 FPDPwfKkrhhKrRllqpellkelarvLkkgGvlelaTDveeyaeemlkvleeeplferlskeeeleeeplsvl 153
+PDP+ K++ +rR+++p l++e+a+ Lk+gG+l +++Dvee+ ++m++ l+ plf +ls+ee +e+++++
tr|Q38E77|Q38E77_TRYB2 141 YPDPHWKRKNVRRRIISPGLVQEYAYWLKVGGFLFTVSDVEELERWMVTCLDGCPLFRQLSQEELAGNEMVRKM 214
**************************************************************988777666443 PP
>> tr|Q4GYR8|Q4GYR8_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=TB
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 19.0 0.0 3.7e-07 0.00035 3 69 .. 398 462 .. 396 467 .. 0.89
Alignments for each domain:
== domain 1 score: 19.0 bits; conditional E-value: 3.7e-07
EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-CCCHHHHCS- CS
Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkiealelkNlrilrgdalkvllelle 69
++l+++cG G++ +alAk+ k ++GiE+ ++ v+ + ++e+++++N +g ++l+++++
tr|Q4GYR8|Q4GYR8_TRYB2 398 TTLLDLCCGTGTIGIALAKHV--KRVIGIELVESAVRDARLNAERNGVRNATFNCGRVEHLLPSVIS 462
5789*********99999985..899*************************9999998777777776 PP
>> tr|Q4GYL1|Q4GYL1_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=TB
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 16.2 0.0 2.7e-06 0.0026 86 135 .. 19 69 .. 17 74 .. 0.84
Alignments for each domain:
== domain 1 score: 16.2 bits; conditional E-value: 2.7e-06
SGGGGGGSTTSHH.HHHHHHHHEEEEEEEEEEESHHHHHHHHHHHHHCSTT CS
Methyltransf_4 86 KkrhhKrRllqpe.llkelarvLkkgGvlelaTDveeyaeemlkvleeepl 135
K++++K+Rl + + + + L gG + l+TD + y + ++v + p+
tr|Q4GYL1|Q4GYL1_TRYB2 19 KRQKKKKRLWGTTnTAGGVRTLLYRGGGILLVTDCFHYLPHLMQVGTCFPS 69
889999***976515667888899*******************99988765 PP
>> tr|Q57Z13|Q57Z13_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 15.1 0.0 5.9e-06 0.0056 53 133 .. 159 245 .. 109 259 .. 0.76
Alignments for each domain:
== domain 1 score: 15.1 bits; conditional E-value: 5.9e-06
EEEEES-CCCHHHHCS-TTSEEEEEEES-----SGGGGGGSTTSHHHHHHHHHHEEEE.......EEEEEEESHHHHHHHHHHHHHC CS
Methyltransf_4 53 lrilrgdalkvllelledgslekifilFPDPwfKkrhhKrRllqpellkelarvLkkg.......GvlelaTDveeyaeemlkvlee 132
+ +r+da+ +l++ll++ + ++ P P+ ++ +Rl+++ + ++r+Lk++ G++ + TD ++ae m+++l e
tr|Q57Z13|Q57Z13_TRYB2 159 TQFVRSDAFFLLQQLLPPSVADTCVVPMPVPFWSEQSSHQRLVTRDFFCVIHRILKEResptdprGFV-TFTDAVPLAEFMMEQLME 244
56799**************************************************9752222222555.569999999999988877 PP
S CS
Methyltransf_4 133 e 133
tr|Q57Z13|Q57Z13_TRYB2 245 S 245
6 PP
>> tr|Q585P9|Q585P9_TRYB2 rRNA adenine N(6)-methyltransferase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 13.6 0.0 1.8e-05 0.017 4 63 .. 91 149 .. 88 160 .. 0.83
2 ? -3.5 0.0 3 2.8e+03 87 112 .. 304 329 .. 301 332 .. 0.77
Alignments for each domain:
== domain 1 score: 13.6 bits; conditional E-value: 1.8e-05
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC.TTSSEEEEES-CCCH CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal.elkNlrilrgdalkv 63
+vleiG G G+++ +l + + k++++ E+ ++va+++k+ +++ + l+++rg+ l++
tr|Q585P9|Q585P9_TRYB2 91 IVLEIGPGTGNLTEKLLQ--AAKKVIAFEVDPRMVAELNKRFQNSpLAPKLQVIRGNCLDH 149
89***********99965..6799********************95445788888887655 PP
== domain 2 score: -3.5 bits; conditional E-value: 3
GGGGGGSTTSHHHHHHHHHHEEEEEE CS
Methyltransf_4 87 krhhKrRllqpellkelarvLkkgGv 112
+r+h +lq+ + ++ arvL ++ +
tr|Q585P9|Q585P9_TRYB2 304 FRQHLESILQEPIFDKRARVLDQESI 329
68888889999999999999887765 PP
>> tr|Q389Z0|Q389Z0_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.7 0.0 3.2e-05 0.03 5 48 .. 214 257 .. 210 280 .. 0.82
Alignments for each domain:
== domain 1 score: 12.7 bits; conditional E-value: 3.2e-05
EEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC CS
Methyltransf_4 5 vleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal 48
vl+++cG G + +a+Ak+ P+ ++ +++i + + + ++++ +
tr|Q389Z0|Q389Z0_TRYB2 214 VLDMCCGTGCVGIAIAKHVPSAQVTAVDILDEAIGASEENAKLN 257
89***************************999998877766655 PP
>> tr|Q386J1|Q386J1_TRYB2 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Trypanosoma brucei brucei (strai
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -2.6 0.0 1.7 1.6e+03 6 29 .. 33 55 .. 30 62 .. 0.76
2 ? 12.3 0.0 4.2e-05 0.04 3 45 .. 152 194 .. 150 244 .. 0.87
Alignments for each domain:
== domain 1 score: -2.6 bits; conditional E-value: 1.7
EEET-TTSHHHHHHHHHSTTSEEE CS
Methyltransf_4 6 leiGcGkGeflvalAkknPdknfl 29
+ +G++ G +lv l +k+ + f+
tr|Q386J1|Q386J1_TRYB2 33 VGVGSAIGALLVYLNNKQTHS-FI 55
678999999999998887653.44 PP
== domain 2 score: 12.3 bits; conditional E-value: 4.2e-05
EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHH CS
Methyltransf_4 3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkki 45
v+++iG+G G++ ++l + +++G+E+ ++ +++ +
tr|Q386J1|Q386J1_TRYB2 152 AVFCDIGSGVGNVCLQLLAETNCRKVVGVEVIPSRHRAATTAF 194
68**************999999999******988877776555 PP
>> tr|Q4GZF2|Q4GZF2_TRYB2 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Trypanosoma brucei brucei (strai
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.4 0.0 4.1e-05 0.039 4 65 .. 114 183 .. 111 193 .. 0.73
Alignments for each domain:
== domain 1 score: 12.4 bits; conditional E-value: 4.1e-05
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC.........TTSSEEEEES-CCCHHH CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal.........elkNlrilrgdalkvll 65
++ ++GcG+G++l + A + +++G+Ei+++ + + ++ +l + + i++gd kvl+
tr|Q4GZF2|Q4GZF2_TRYB2 114 TFYDLGCGNGSVLFHVALATG-ASCVGVEINEHNAKVAKEAWTHLrpvfekrrgRKLDVSIVCGDFCKVLK 183
689**************9875.689*****98766555555444455566666655566777777766665 PP
>> tr|Q581Z0|Q581Z0_TRYB2 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Trypanosoma brucei brucei (strai
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.4 0.0 8.1e-05 0.077 4 62 .. 131 198 .. 128 215 .. 0.71
Alignments for each domain:
== domain 1 score: 11.4 bits; conditional E-value: 8.1e-05
EEEEET-TTSHHHHHHHHHSTTSEEEEEES-H...HHHHHHHHHHHHC.......TTSSEEEEES-CCC CS
Methyltransf_4 4 vvleiGcGkGeflvalAkknPdknflGiEirv...kvvakvlkkieal.......elkNlrilrgdalk 62
++ ++GcG+G++l + A ++GiEi++ kv +k+++ i+ + + ++i+ +d +k
tr|Q581Z0|Q581Z0_TRYB2 131 TFYDLGCGNGSILFQVAFLTG-ARCVGIEISEhnaKVAKKAWEVIRPElegssgrSMPEVNIITSDMTK 198
789**************9875.6899***9872224455566655555666666555566666666555 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (173 nodes)
Target sequences: 8561 (4332363 residues searched)
Passed MSV filter: 234 (0.0273333); expected 171.2 (0.02)
Passed bias filter: 189 (0.0220769); expected 171.2 (0.02)
Passed Vit filter: 31 (0.00362107); expected 8.6 (0.001)
Passed Fwd filter: 9 (0.00105128); expected 0.1 (1e-05)
Initial search space (Z): 8561 [actual number of targets]
Domain search space (domZ): 9 [number of targets reported over threshold]
# CPU time: 0.08u 0.00s 00:00:00.08 Elapsed: 00:00:00.04
# Mc/sec: 18737.47
//
[ok]