# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_5.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_5 [M=309] Accession: PF01795.18 Description: MraW methylase family Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 9.8e-90 303.4 0.0 3.8e-89 301.5 0.0 1.7 1 sp|A6NJ78|MET15_HUMAN Probable methyltransferase-like prot 3.1e-57 196.7 0.0 4e-57 196.3 0.0 1.1 1 sp|A6NJ78-2|MET15_HUMAN Isoform 2 of Probable methyltransfer 2e-37 131.7 0.0 2.6e-37 131.3 0.0 1.1 1 sp|A6NJ78-4|MET15_HUMAN Isoform 4 of Probable methyltransfer 9.1e-35 122.9 0.0 1.1e-34 122.6 0.0 1.1 1 sp|P0C7V9|ME15P_HUMAN Putative methyltransferase-like prot ------ inclusion threshold ------ 0.61 11.8 0.0 0.66 11.7 0.0 1.1 1 tr|H7C258|H7C258_HUMAN HemK methyltransferase family member Domain annotation for each sequence (and alignments): >> sp|A6NJ78|MET15_HUMAN Probable methyltransferase-like protein 15 OS=Homo sapiens GN=METTL15 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 301.5 0.0 2.1e-93 3.8e-89 3 307 .. 71 405 .. 69 407 .] 0.88 Alignments for each domain: == domain 1 score: 301.5 bits; conditional E-value: 2.1e-93 XX--TTTHHHHHHT---TT-EEEES--TTSHHHHHHHTT--TTEEEEEES-HHHHHHHTT.....---EEEEES-GGGHHHHHHHTTT CS Methyltransf_5 3 eHvpVLlqevvellepkedgvyiDaTlGaggHsealLeqlselrligidrDksalarakerLkefekrltlvkgnfkelkealaeanv 90 H+pV+++evv+ l+p+++++++D+T+G+ggH++a+L++ s+ l+++drD++a a a++ + + k+++ + g+f++ ++ l +a+v sp|A6NJ78|MET15_HUMAN 71 LHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGV 158 6***********************************************************77788899******************97 PP T..-EEEEEEE-S--HHHHH-GGG---SSS--BS---S-TTS..S-.-HHHHHHH--HHHHHHHHHHHH--TTHHHHHHHHHHHHHHS CS Methyltransf_5 91 t..kvdgillDLGvSslqldkaerGFsfaedapLDmRmdqsa..el.tAaevlnrlseeeLakilkeygeekfakriakaivekrkkk 173 + ++dg+l+DLG Ss+qld++erGFs ++d+pLDmRmd + ++ tAa+v+n l++++La+il++ygeek+ak+ia aiv++r+ sp|A6NJ78|MET15_HUMAN 159 QpgTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGRypDMpTAADVVNALDQQALASILRTYGEEKHAKKIASAIVQARSIY 246 6669***********************************87622346***************************************** PP ---BHHHHHHHHHHHS-------.........-TTHHHHHHHHHHHHTHHHHHHHHHHHHHHHEEEEEEEEEEESSHHHHHHHHHHHH CS Methyltransf_5 174 piettkelaevikkvvpakekrk.......kihpatrvFQAlRIavNdEleeleelleaalellakggrlavisFhSledrivkkvfk 254 pi++t++la++++ ++p+++ + ++h at++FQAlRI+vN+El+el + l++a + l++ggrl+ +sFhSledrivk+++ sp|A6NJ78|MET15_HUMAN 247 PITRTQQLASIVAGAFPPSAIYTrkdllqrSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALSFHSLEDRIVKRFLL 334 *****************98766556899889*******************************************************97 PP HTT------------------..................-EEEEE.E.E---HHHHHH-GGGTT-EEEEEE CS Methyltransf_5 255 easkkeevPaglpvaseelka..................klklitkkpilpseeeikeNprsrsakLrvie 307 s +e+ ++ + ++++ +li kk++ p ++++++Npr rsakLr++ sp|A6NJ78|MET15_HUMAN 335 GISMTERFNLSVRQQVMKTSQlgsdhenteevsmrraplMWELIHKKVLSPQDQDVQDNPRGRSAKLRAAI 405 666544332222211111111222334455677887777789**************************975 PP >> sp|A6NJ78-2|MET15_HUMAN Isoform 2 of Probable methyltransferase-like protein 15 OS=Homo sapiens GN=METTL15 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 196.3 0.0 2.3e-61 4e-57 3 188 .. 71 261 .. 69 268 .. 0.94 Alignments for each domain: == domain 1 score: 196.3 bits; conditional E-value: 2.3e-61 XX--TTTHHHHHHT---TT-EEEES--TTSHHHHHHHTT--TTEEEEEES-HHHHHHHTT.....---EEEEES-GGGHHHHHHHT CS Methyltransf_5 3 eHvpVLlqevvellepkedgvyiDaTlGaggHsealLeqlselrligidrDksalarakerLkefekrltlvkgnfkelkealaea 88 H+pV+++evv+ l+p+++++++D+T+G+ggH++a+L++ s+ l+++drD++a a a++ + + k+++ + g+f++ ++ l +a sp|A6NJ78-2|MET15_HUMAN 71 LHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKA 156 6***********************************************************77788899****************** PP TTT..-EEEEEEE-S--HHHHH-GGG---SSS--BS---S-TTS..S-.-HHHHHHH--HHHHHHHHHHHH--TTHHHHHHHHHHH CS Methyltransf_5 89 nvt..kvdgillDLGvSslqldkaerGFsfaedapLDmRmdqsa..el.tAaevlnrlseeeLakilkeygeekfakriakaivek 169 +v+ ++dg+l+DLG Ss+qld++erGFs ++d+pLDmRmd + ++ tAa+v+n l++++La+il++ygeek+ak+ia aiv++ sp|A6NJ78-2|MET15_HUMAN 157 GVQpgTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGRypDMpTAADVVNALDQQALASILRTYGEEKHAKKIASAIVQA 242 976669***********************************87622346************************************* PP HHHS---BHHHHHHHHHHH CS Methyltransf_5 170 rkkkpiettkelaevikkv 188 r+ pi++t++la+++++ sp|A6NJ78-2|MET15_HUMAN 243 RSIYPITRTQQLASIVAEY 261 ****************975 PP >> sp|A6NJ78-4|MET15_HUMAN Isoform 4 of Probable methyltransferase-like protein 15 OS=Homo sapiens GN=METTL15 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 131.3 0.0 1.5e-41 2.6e-37 3 130 .. 71 200 .. 69 206 .. 0.94 Alignments for each domain: == domain 1 score: 131.3 bits; conditional E-value: 1.5e-41 XX--TTTHHHHHHT---TT-EEEES--TTSHHHHHHHTT--TTEEEEEES-HHHHHHHTT.....---EEEEES-GGGHHHHHHHT CS Methyltransf_5 3 eHvpVLlqevvellepkedgvyiDaTlGaggHsealLeqlselrligidrDksalarakerLkefekrltlvkgnfkelkealaea 88 H+pV+++evv+ l+p+++++++D+T+G+ggH++a+L++ s+ l+++drD++a a a++ + + k+++ + g+f++ ++ l +a sp|A6NJ78-4|MET15_HUMAN 71 LHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKA 156 6***********************************************************77788899****************** PP TTT..-EEEEEEE-S--HHHHH-GGG---SSS--BS---S-TTS CS Methyltransf_5 89 nvt..kvdgillDLGvSslqldkaerGFsfaedapLDmRmdqsa 130 +v+ ++dg+l+DLG Ss+qld++erGFs ++d+pLDmRmd + sp|A6NJ78-4|MET15_HUMAN 157 GVQpgTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGR 200 976669**********************************9765 PP >> sp|P0C7V9|ME15P_HUMAN Putative methyltransferase-like protein 15P1 OS=Homo sapiens GN=METTL15P1 PE=5 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 122.6 0.0 6.3e-39 1.1e-34 3 133 .. 71 203 .. 69 226 .. 0.93 Alignments for each domain: == domain 1 score: 122.6 bits; conditional E-value: 6.3e-39 XX--TTTHHHHHHT---TT-EEEES--TTSHHHHHHHTT--TTEEEEEES-HHHHHHHTT.....---EEEEES-GGGHHHHHHHTTT CS Methyltransf_5 3 eHvpVLlqevvellepkedgvyiDaTlGaggHsealLeqlselrligidrDksalarakerLkefekrltlvkgnfkelkealaeanv 90 H+pV+++evv+ l+p+++++++D+T+G+ggH++a+L++ s+ l+++drD++a a a++ + + k+++ + g+f++ ++ l +a+v sp|P0C7V9|ME15P_HUMAN 71 LHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGV 158 6***********************************************************77788899******************97 PP T..-EEEEEEE-S--HHHHH-GGG---SSS--BS---S-TTSS-- CS Methyltransf_5 91 t..kvdgillDLGvSslqldkaerGFsfaedapLDmRmdqsaelt 133 + ++dg+l+DLG Ss+qld++erG s ++d+pLD+Rmd ++ + sp|P0C7V9|ME15P_HUMAN 159 QpgTFDGVLMDLGCSSMQLDTPERGSSLRKDGPLDIRMDGGRNIS 203 6669***********************************887765 PP >> tr|H7C258|H7C258_HUMAN HemK methyltransferase family member 1 (Fragment) OS=Homo sapiens GN=HEMK1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.7 0.0 3.7e-05 0.66 28 69 .. 5 46 .. 1 68 [. 0.90 Alignments for each domain: == domain 1 score: 11.7 bits; conditional E-value: 3.7e-05 --TTSHHHHHHHTT--TTEEEEEES-HHHHHHHTT.....-- CS Methyltransf_5 28 TlGaggHsealLeqlselrligidrDksalarakerLkefek 69 G+g s lL+ql++ r+i++d+ + a+ ++e+ +++e+ tr|H7C258|H7C258_HUMAN 5 GCGSGAISLSLLSQLPQSRVIAVDKREAAISLTHENAQSYED 46 5799999****************************9999987 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (309 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 2646 (0.0299074); expected 1769.5 (0.02) Passed bias filter: 1498 (0.0169317); expected 1769.5 (0.02) Passed Vit filter: 114 (0.00128853); expected 88.5 (0.001) Passed Fwd filter: 5 (5.65144e-05); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 5 [number of targets reported over threshold] # CPU time: 0.71u 0.02s 00:00:00.73 Elapsed: 00:00:00.26 # Mc/sec: 41679.96 // [ok]