# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_8.hmm.txt
# target sequence database: proteomes/Ciona_savignyi.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_8 [M=219]
Accession: PF05148.15
Description: Hypothetical methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
5.9e-84 280.7 0.1 8.5e-84 280.2 0.1 1.2 1 tr|H2Z072|H2Z072_CIOSA Uncharacterized protein OS=Ciona savi
4.7e-07 29.3 0.5 2.9e-05 23.4 0.1 2.3 2 tr|H2YGP5|H2YGP5_CIOSA Uncharacterized protein OS=Ciona savi
1.1e-06 28.0 0.0 2e-06 27.2 0.0 1.4 1 tr|H2Y8E5|H2Y8E5_CIOSA Uncharacterized protein OS=Ciona savi
0.00017 20.9 0.1 0.053 12.7 0.0 2.3 2 tr|H2YK68|H2YK68_CIOSA S-adenosylmethionine sensor upstream
0.00053 19.3 0.0 0.00059 19.1 0.0 1.1 1 tr|H2Z5E6|H2Z5E6_CIOSA Uncharacterized protein OS=Ciona savi
0.0009 18.5 0.0 0.0013 18.0 0.0 1.2 1 tr|H2Z0R4|H2Z0R4_CIOSA Uncharacterized protein OS=Ciona savi
0.0011 18.3 0.0 0.01 15.1 0.0 2.0 1 tr|H2Z439|H2Z439_CIOSA Uncharacterized protein OS=Ciona savi
------ inclusion threshold ------
0.043 13.0 0.0 0.26 10.5 0.0 2.0 1 tr|H2ZL66|H2ZL66_CIOSA Uncharacterized protein OS=Ciona savi
0.053 12.7 0.0 0.19 10.9 0.0 1.9 2 tr|H2Z0X8|H2Z0X8_CIOSA Uncharacterized protein OS=Ciona savi
0.054 12.7 0.0 0.15 11.3 0.0 1.6 2 tr|H2YJS4|H2YJS4_CIOSA Uncharacterized protein OS=Ciona savi
Domain annotation for each sequence (and alignments):
>> tr|H2Z072|H2Z072_CIOSA Uncharacterized protein OS=Ciona savignyi OX=51511 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 280.2 0.1 7.3e-87 8.5e-84 2 219 .] 180 399 .] 179 399 .] 0.95
Alignments for each domain:
== domain 1 score: 280.2 bits; conditional E-value: 7.3e-87
XXXXX-HHHHHHHHHHHHHHHHHS-HHHHHHHHHH-HHHHHHHHHHHHHHHCTSSS-HHHHHHHHHCTS-TTS-EEEES-TT-HHHH CS
Methyltransf_8 2 leakikkrldgarfrflneklytgesskavdlfkedpeafdlyhkgfrsqvkkWPenPldviirklkkkkdnlvvadlGcGeakiae 88
l++++ ++l+++rfrf+ne++y+ +s +lf+ dp+af++yh+gf qv WP+nPld +ir++k++ +l++ad+GcGea +a+
tr|H2Z072|H2Z072_CIOSA 180 LKDRLVEKLESSRFRFINEQIYSQSSGDTHELFNSDPTAFQVYHRGFGAQVATWPVNPLDGVIRWVKERSPKLIIADFGCGEAMLAS 266
78999*********************************************************************************9 PP
H--S-..EEEEESS-SSTTEEES-TTS-S--TT-EEEEEEES---SS-HHHHHHHHHHHEEEEEEEEEEEEGGG-S-HHHHHHHHHC CS
Methyltransf_8 89 avrekekvrsfdlvavnervvacdlakvPledesvdvavfclslmgtnladflkeanrvlkvGGllkvaevksrfesvklfaraltk 175
+v++k v+sfdlvavn+rv++ d+akvPl+d+svd++vfclslmgtnl +fl eanrvlk G+lk+aev srf+ k+f r+l+k
tr|H2Z072|H2Z072_CIOSA 267 SVKNK--VHSFDLVAVNDRVTVADIAKVPLADSSVDIVVFCLSLMGTNLVEFLVEANRVLKLRGVLKIAEVASRFSGLKQFYRDLKK 351
99887..******************************************************************************** PP
TTEEEEEEE--STTEEEEEEEE-SSS-TT...---.GG--------XX CS
Methyltransf_8 176 lGfevkskdlsnkqfvlfefkkvekkgkk...rel.glklkpclykkr 219
+Gf+ ++kd +n++f++f+f k+++ + +++ glklk+c ykkr
tr|H2Z072|H2Z072_CIOSA 352 IGFDLHKKDTTNSHFFMFDFFKTKNSPPSclsNDYsGLKLKACAYKKR 399
***********************97665312234459**********9 PP
>> tr|H2YGP5|H2YGP5_CIOSA Uncharacterized protein OS=Ciona savignyi OX=51511 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 4.2 0.1 0.019 22 74 103 .. 32 65 .. 27 72 .. 0.78
2 ! 23.4 0.1 2.5e-08 2.9e-05 99 161 .. 82 146 .. 61 158 .. 0.77
Alignments for each domain:
== domain 1 score: 4.2 bits; conditional E-value: 0.019
S-EEEES-TT-H....HHHH--S-..EEEEESS- CS
Methyltransf_8 74 lvvadlGcGeak....iaeavrekekvrsfdlva 103
l v+dlGcG + ia+ v+e+ +v+ +d++
tr|H2YGP5|H2YGP5_CIOSA 32 LKVVDLGCGSGRdcyaIAQLVGENGEVIGVDMTK 65
5699*****9875555888889999999998865 PP
== domain 2 score: 23.4 bits; conditional E-value: 2.5e-08
EESS-SSTTEEES-TTS-S.--TT-EEEEEE.ES---SS-HHHHHHHHHHHEEEEEEEEEEEEGG CS
Methyltransf_8 99 fdlvavnervvacdlakvP.ledesvdvavf.clslmgtnladflkeanrvlkvGGllkvaevks 161
f ++ n r v + + ++d+svd+a+ c+ + +n + ke+ r+lk+GG ++ +++ s
tr|H2YGP5|H2YGP5_CIOSA 82 FGFKESNVRFVEGYIEDLSfIADSSVDIAISnCVVNLCENKEAVFKEVFRILKTGGEFYWSDIYS 146
5555566666666665554269*******955**************************9999977 PP
>> tr|H2Y8E5|H2Y8E5_CIOSA Uncharacterized protein OS=Ciona savignyi OX=51511 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 27.2 0.0 1.7e-09 2e-06 117 162 .. 143 189 .. 99 202 .. 0.81
Alignments for each domain:
== domain 1 score: 27.2 bits; conditional E-value: 1.7e-09
S--TT-EEEEEE.ES---SS-HHHHHHHHHHHEEEEEEEEEEEEGGG CS
Methyltransf_8 117 Pledesvdvavf.clslmgtnladflkeanrvlkvGGllkvaevksr 162
++desvd+++ c+ ++++ + lkea+rvlk GG l+ ++v s
tr|H2Y8E5|H2Y8E5_CIOSA 143 GIADESVDIIISnCVINLVKDKEAVLKEAYRVLKYGGELYFSDVYSD 189
589******99549999**************************9985 PP
>> tr|H2YK68|H2YK68_CIOSA S-adenosylmethionine sensor upstream of mTORC1 OS=Ciona savignyi OX=51511 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 12.7 0.0 4.6e-05 0.053 57 121 .. 108 171 .. 94 186 .. 0.82
2 ! 6.1 0.0 0.0049 5.7 122 200 .. 195 281 .. 174 294 .. 0.68
Alignments for each domain:
== domain 1 score: 12.7 bits; conditional E-value: 4.6e-05
S-HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH--S-..EEEEESS-SSTTEEES-TTS-S--TT CS
Methyltransf_8 57 enPldviirklkkkkdnlvvadlGcGeakiaeavrekekvrsfdlvavnervvacdlakvPlede 121
+nP d+++++ k+ ++n ++ l G + ++ ++ + ++dl + n+ v cd+ v + d
tr|H2YK68|H2YK68_CIOSA 108 KNPCDKVLKS-KSPQQNGSIRLLDVGSCYNPFSEMQEFETTAIDLSPANDTVYQCDFISVEVSDV 171
5788887765.56667778887888888888888888899*****************99998885 PP
== domain 2 score: 6.1 bits; conditional E-value: 0.0049
-EEEEEEES---S....S-HHHHHHHHHHHEEEEEEEEEEEEGGG-S.....-HHHHHHHHHCTTEEEEEEE--STTEEEEEEEE-S CS
Methyltransf_8 122 svdvavfclslmg....tnladflkeanrvlkvGGllkvaevksrfe.....svklfaraltklGfevkskdlsnkqfvlfefkkve 199
dv+vf l l + ++ a++vl + G+l + s + ++k+++ ++++Gf+ + +++ ++ l+ f+k++
tr|H2YK68|H2YK68_CIOSA 195 HYDVVVFSLLLSYipcpQARWEMCVKAHQVLSTNGILIIITPDSCHQnkhasNMKKWKLSIEEIGFQRIKY-EKDVHLHLMAFRKTP 280
457777766554311112223445568999*99999999888776554444478889999******87654.5678999******98 PP
S CS
Methyltransf_8 200 k 200
tr|H2YK68|H2YK68_CIOSA 281 F 281
4 PP
>> tr|H2Z5E6|H2Z5E6_CIOSA Uncharacterized protein OS=Ciona savignyi OX=51511 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 19.1 0.0 5.1e-07 0.00059 114 161 .. 23 71 .. 14 107 .. 0.78
Alignments for each domain:
== domain 1 score: 19.1 bits; conditional E-value: 5.1e-07
TS-S--TT-EEEEEEES---SS-HH.HHHHHHHHHEEEEEEEEEEEEGG CS
Methyltransf_8 114 akvPledesvdvavfclslmgtnla.dflkeanrvlkvGGllkvaevks 161
+++P++d s dv++ + ++ d +k++ r+lk+GG+++ + ks
tr|H2Z5E6|H2Z5E6_CIOSA 23 NRIPVDDASYDVIISIGGFSPSHIQaDCIKDVVRLLKPGGIFWFSIRKS 71
68*************9999999986479**************9875554 PP
>> tr|H2Z0R4|H2Z0R4_CIOSA Uncharacterized protein OS=Ciona savignyi OX=51511 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.0 0.0 1.1e-06 0.0013 115 199 .. 117 206 .. 108 216 .. 0.67
Alignments for each domain:
== domain 1 score: 18.0 bits; conditional E-value: 1.1e-06
S-S--TT-EEEEEEES---SS-HH.HHHHHHHHHEEEEEEEEEEEEGGG-S..-HHHHHHHHHCTTEEEEEEE--S..TTEEEEEEE CS
Methyltransf_8 115 kvPledesvdvavfclslmgtnla.dflkeanrvlkvGGllkvaevksrfe..svklfaraltklGfevkskdlsn..kqfvlfefk 196
+Pl+d+ dv+ + s+ + ++ + lke rv k+GG++ a v++ + +++a+ +++l + k+l+ + + ++f
tr|H2Z0R4|H2Z0R4_CIOSA 117 ALPLKDQMYDVTCCLGSMSVPHIQpEALKEFVRVTKTGGMMGFAVVTTPRSgaYEQKLAEIVKSLENSGQWKNLKAikSAIFQYNFD 203
68********98666688888888568*****************9987444332334555555554444444433300333344555 PP
E-S CS
Methyltransf_8 197 kve 199
k++
tr|H2Z0R4|H2Z0R4_CIOSA 204 KID 206
555 PP
>> tr|H2Z439|H2Z439_CIOSA Uncharacterized protein OS=Ciona savignyi OX=51511 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 15.1 0.0 8.6e-06 0.01 59 176 .. 15 151 .. 7 171 .. 0.66
Alignments for each domain:
== domain 1 score: 15.1 bits; conditional E-value: 8.6e-06
HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH--S-..EE....EEE....S..S-SSTTE....EES....-TTS-S--TT-EEEEE CS
Methyltransf_8 59 PldviirklkkkkdnlvvadlGcGeakiaeavrekekvr....sfd....l..vavnerv....vac....dlakvPledesvdvav 127
d++++++k + + v dlG G +++ r++ + + +d + +a +++v + c d +Pl d + dv+v
tr|H2Z439|H2Z439_CIOSA 15 ITDMFLKHVKDRTNT-KVLDLGGGTGSVSQLLRNQLQFKgeidILDanmdMlyKASKKEVgfsnILChwigDSGDLPLRDATYDVIV 100
568889999988765.56799999999998888877654211133322222223445555333345644446679************ PP
EES---SS-HHHH.HHHHHHHEEEEEEEEEE.EEGGG-S-HHHHHHHHHCT CS
Methyltransf_8 128 fclslmgtnladf.lkeanrvlkvGGllkva.evksrfesvklfaraltkl 176
+ +++ + + + +k + +v+k+ Gll ++ +++ + k+++ ++++l
tr|H2Z439|H2Z439_CIOSA 101 CAAAFLPNHIPAPaIKGILKVIKPEGLLLLTmRLETTGSYEKVLQDNIKQL 151
*********976539***********9986412333333344455555555 PP
>> tr|H2ZL66|H2ZL66_CIOSA Uncharacterized protein OS=Ciona savignyi OX=51511 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.5 0.0 0.00023 0.26 71 154 .. 70 167 .. 54 178 .. 0.69
Alignments for each domain:
== domain 1 score: 10.5 bits; conditional E-value: 0.00023
-TTS-EEEES-TT-HHHHH--S-..EEEE...E......SS-SSTTEEES-T....TS-S--TT-EEEEEEES---.SS-HHHHHHH CS
Methyltransf_8 71 kdnlvvadlGcGeakiaeavrekekvrsf...d......lvavnervvacdl....akvPledesvdvavfclslm.gtnladflke 143
k++ dlGcG i+++ +e++ + + d + ++++++ + +P ++ d+++ +sl +++l + ke
tr|H2ZL66|H2ZL66_CIOSA 70 KSSPLALDLGCGRGYISQELSEFDGIDLLfqgDtsqsylNNPCQPKLTTHSVnfneESLPFRTDTFDMVLSSMSLHwVNDLPKCFKE 156
45555678888888888888877666433122111111023333443332222133689***************964889******* PP
HHHHEEEEEEE CS
Methyltransf_8 144 anrvlkvGGll 154
+ r+lk+ G +
tr|H2ZL66|H2ZL66_CIOSA 157 VLRILKPDGCF 167
******99975 PP
>> tr|H2Z0X8|H2Z0X8_CIOSA Uncharacterized protein OS=Ciona savignyi OX=51511 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.9 0.0 0.00017 0.19 33 73 .. 16 56 .. 12 98 .. 0.80
2 ? -2.2 0.0 1.7 1.9e+03 37 59 .. 181 198 .. 175 201 .. 0.80
Alignments for each domain:
== domain 1 score: 10.9 bits; conditional E-value: 0.00017
HHHH-HHHHHHHHHHHHHHHCTSSS-HHHHHHHHHCTS-TT CS
Methyltransf_8 33 lfkedpeafdlyhkgfrsqvkkWPenPldviirklkkkkdn 73
++ e+ +fd+y ++ + + + P++P++ +i +lk+ ++
tr|H2Z0X8|H2Z0X8_CIOSA 16 VYAEEHGIFDMYKRLLCQLIINKPTEPIQYVIDWLKRDNNP 56
6789999****************************987664 PP
== domain 2 score: -2.2 bits; conditional E-value: 1.7
-HHHHHHHHHHHHHHHCTSSS-H CS
Methyltransf_8 37 dpeafdlyhkgfrsqvkkWPenP 59
dp+ d+yh f+ WP++P
tr|H2Z0X8|H2Z0X8_CIOSA 181 DPTTGDVYHTTFD-----WPQDP 198
89999****9995.....66666 PP
>> tr|H2YJS4|H2YJS4_CIOSA Uncharacterized protein OS=Ciona savignyi OX=51511 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -1.8 0.0 1.3 1.5e+03 73 93 .. 80 100 .. 59 113 .. 0.78
2 ? 11.3 0.0 0.00013 0.15 115 156 .. 138 180 .. 125 200 .. 0.86
Alignments for each domain:
== domain 1 score: -1.8 bits; conditional E-value: 1.3
TS-EEEES-TT-HHHHH--S- CS
Methyltransf_8 73 nlvvadlGcGeakiaeavrek 93
+ + d+G G ++a a ++
tr|H2YJS4|H2YJS4_CIOSA 80 SFTALDIGAGTGQMAIALKNI 100
556689999999999776654 PP
== domain 2 score: 11.3 bits; conditional E-value: 0.00013
S-S--TT-EEEEEEES---SS-HH.HHHHHHHHHEEEEEEEEE CS
Methyltransf_8 115 kvPledesvdvavfclslmgtnla.dflkeanrvlkvGGllkv 156
+P e + d +v+c +++ ++ + l ++ rv+k+GG l+
tr|H2YJS4|H2YJS4_CIOSA 138 PLPYESNKYDAVVCCCAMVPALIQpECLPDMARVVKPGGQLYF 180
5899999**********999999856899***********996 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (219 nodes)
Target sequences: 11592 (4231397 residues searched)
Passed MSV filter: 283 (0.0244134); expected 231.8 (0.02)
Passed bias filter: 200 (0.0172533); expected 231.8 (0.02)
Passed Vit filter: 27 (0.00232919); expected 11.6 (0.001)
Passed Fwd filter: 10 (0.000862664); expected 0.1 (1e-05)
Initial search space (Z): 11592 [actual number of targets]
Domain search space (domZ): 10 [number of targets reported over threshold]
# CPU time: 0.09u 0.00s 00:00:00.09 Elapsed: 00:00:00.03
# Mc/sec: 30889.20
//
[ok]