# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_8.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_8 [M=219] Accession: PF05148.15 Description: Hypothetical methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 4.3e-106 355.9 0.0 5.4e-106 355.6 0.0 1.1 1 sp|O43159|RRP8_HUMAN Ribosomal RNA-processing protein 8 O 2.1e-47 164.1 0.0 2.6e-47 163.8 0.0 1.0 1 tr|E9PPP6|E9PPP6_HUMAN Ribosomal RNA-processing protein 8 O 4.7e-30 107.3 0.1 6.3e-30 106.9 0.1 1.2 1 tr|E9PPY3|E9PPY3_HUMAN Ribosomal RNA-processing protein 8 O 3e-05 26.2 0.0 4.8e-05 25.6 0.0 1.2 1 sp|Q9P272|K1456_HUMAN Putative methyltransferase KIAA1456 3.6e-05 26.0 0.0 6e-05 25.3 0.0 1.3 1 sp|Q9H8H3|MET7A_HUMAN Methyltransferase-like protein 7A OS 3.6e-05 26.0 0.0 6e-05 25.3 0.0 1.3 1 tr|H0YI09|H0YI09_HUMAN Methyltransferase-like protein 7A (F 4.5e-05 25.7 0.1 7.8e-05 24.9 0.1 1.3 1 tr|F8VQX6|F8VQX6_HUMAN Methyltransferase-like protein 7A (F 0.00018 23.7 0.0 0.00042 22.5 0.0 1.5 2 sp|Q6UX53|MET7B_HUMAN Methyltransferase-like protein 7B OS 0.00026 23.2 0.0 0.00046 22.4 0.0 1.3 1 sp|Q96BT7|ALKB8_HUMAN Alkylated DNA repair protein alkB ho 0.00027 23.1 0.0 0.00046 22.4 0.0 1.3 1 sp|Q96BT7-4|ALKB8_HUMAN Isoform 4 of Alkylated DNA repair pr 0.00037 22.7 0.0 0.00095 21.3 0.0 1.7 1 sp|Q9HBK9|AS3MT_HUMAN Arsenite methyltransferase OS=Homo s 0.00091 21.4 0.0 0.016 17.3 0.0 2.3 3 tr|B4DP72|B4DP72_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquin 0.0013 20.9 0.0 0.026 16.6 0.0 2.6 3 sp|Q5HYK3|COQ5_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquin 0.0045 19.1 0.0 0.012 17.7 0.0 1.7 2 tr|F8VVX6|F8VVX6_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquin ------ inclusion threshold ------ 0.052 15.7 0.0 0.25 13.4 0.0 2.0 2 sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS 0.15 14.1 0.0 4.8 9.2 0.0 2.2 1 sp|Q9NZJ6|COQ3_HUMAN Hexaprenyldihydroxybenzoate methyltr 0.17 14.0 0.0 0.42 12.7 0.0 1.7 1 tr|B3KR61|B3KR61_HUMAN HCG1811060, isoform CRA_c OS=Homo sa 0.58 12.2 0.0 0.93 11.6 0.0 1.2 1 tr|H7C552|H7C552_HUMAN Methyltransferase-like protein 2B (F 0.59 12.2 0.0 1.1 11.3 0.0 1.4 1 sp|Q96IZ6-2|MET2A_HUMAN Isoform 2 of Methyltransferase-like 1.1 11.3 0.0 1.7 10.7 0.0 1.3 1 tr|F6XBY7|F6XBY7_HUMAN Uncharacterized protein KIAA1456 OS= Domain annotation for each sequence (and alignments): >> sp|O43159|RRP8_HUMAN Ribosomal RNA-processing protein 8 OS=Homo sapiens GN=RRP8 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 355.6 0.0 1.2e-109 5.4e-106 2 219 .] 238 456 .] 237 456 .] 0.99 Alignments for each domain: == domain 1 score: 355.6 bits; conditional E-value: 1.2e-109 XXXXX-HHHHHHHHHHHHHHHHHS-HHHHHHHHHH-HHHHHHHHHHHHHHHCTSSS-HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH- CS Methyltransf_8 2 leakikkrldgarfrflneklytgesskavdlfkedpeafdlyhkgfrsqvkkWPenPldviirklkkkkdnlvvadlGcGeakiaeav 90 l+a++++rldgarfr+lne+ly+g+ss+a++lf+edpeaf lyh+gf+sqvkkWP +P+d+i+r+l++++++lvvad+GcG++++a+++ sp|O43159|RRP8_HUMAN 238 LRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCRLASSI 326 899************************************************************************************** PP -S-..EEEEESS-SSTTEEES-TTS-S--TT-EEEEEEES---SS-HHHHHHHHHHHEEEEEEEEEEEEGGG-S-HHHHHHHHHCTTEE CS Methyltransf_8 91 rekekvrsfdlvavnervvacdlakvPledesvdvavfclslmgtnladflkeanrvlkvGGllkvaevksrfesvklfaraltklGfe 179 r++ v++fdl+++++rv++cd+a+vPledesvdvavfclslmgtn++dfl+eanrvlk+GGllkvaev+srfe+v++f+ra+tklGf+ sp|O43159|RRP8_HUMAN 327 RNP--VHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFK 413 **9..************************************************************************************ PP EEEEE--STTEEEEEEEE-S..SS-TT---.GG--------XX CS Methyltransf_8 180 vkskdlsnkqfvlfefkkve..kkgkkrel.glklkpclykkr 219 ++skdl+n++f+lf+f+k++ +g+k++l gl+l+pclyk+r sp|O43159|RRP8_HUMAN 414 IVSKDLTNSHFFLFDFQKTGppLVGPKAQLsGLQLQPCLYKRR 456 *******************8889*****9989**********9 PP >> tr|E9PPP6|E9PPP6_HUMAN Ribosomal RNA-processing protein 8 OS=Homo sapiens GN=RRP8 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 163.8 0.0 5.8e-51 2.6e-47 114 219 .] 32 140 .] 26 140 .] 0.97 Alignments for each domain: == domain 1 score: 163.8 bits; conditional E-value: 5.8e-51 TS-S--TT-EEEEEEES---SS-HHHHHHHHHHHEEEEEEEEEEEEGGG-S-HHHHHHHHHCTTEEEEEEE--STTEEEEEEEE-S. CS Methyltransf_8 114 akvPledesvdvavfclslmgtnladflkeanrvlkvGGllkvaevksrfesvklfaraltklGfevkskdlsnkqfvlfefkkve. 199 +kvPledesvdvavfclslmgtn++dfl+eanrvlk+GGllkvaev+srfe+v++f+ra+tklGf+++skdl+n++f+lf+f+k++ tr|E9PPP6|E9PPP6_HUMAN 32 NKVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLTNSHFFLFDFQKTGp 118 69***********************************************************************************88 PP .SS-TT---.GG--------XX CS Methyltransf_8 200 .kkgkkrel.glklkpclykkr 219 +g+k++l gl+l+pclyk+r tr|E9PPP6|E9PPP6_HUMAN 119 pLVGPKAQLsGLQLQPCLYKRR 140 89*****9989**********9 PP >> tr|E9PPY3|E9PPY3_HUMAN Ribosomal RNA-processing protein 8 OS=Homo sapiens GN=RRP8 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 106.9 0.1 1.4e-33 6.3e-30 2 70 .. 238 306 .] 237 306 .] 0.98 Alignments for each domain: == domain 1 score: 106.9 bits; conditional E-value: 1.4e-33 XXXXX-HHHHHHHHHHHHHHHHHS-HHHHHHHHHH-HHHHHHHHHHHHHHHCTSSS-HHHHHHHHHCTS CS Methyltransf_8 2 leakikkrldgarfrflneklytgesskavdlfkedpeafdlyhkgfrsqvkkWPenPldviirklkkk 70 l+a++++rldgarfr+lne+ly+g+ss+a++lf+edpeaf lyh+gf+sqvkkWP +P+d+i+r+l+++ tr|E9PPY3|E9PPY3_HUMAN 238 LRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQR 306 899****************************************************************97 PP >> sp|Q9P272|K1456_HUMAN Putative methyltransferase KIAA1456 OS=Homo sapiens GN=KIAA1456 PE=2 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.6 0.0 1.1e-08 4.8e-05 50 156 .. 27 139 .. 3 158 .. 0.71 Alignments for each domain: == domain 1 score: 25.6 bits; conditional E-value: 1.1e-08 HHHCTSSS-HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH--S-..EEE...EESS-SST....TEEES-TTS-S--TT-EEEEEE.. CS Methyltransf_8 50 sqvkkWPenPldviirklkkkkdnlvvadlGcGeakiaeavrekekvrs...fdlvavne....rvvacdlakvPledesvdvavf.. 128 q k WP + + l+++k +ad+GcG k + ++ + v + lv + + ++cd ++P de d ++ sp|Q9P272|K1456_HUMAN 27 LQSKAWPR-----VRQFLQEQKPGSLIADIGCGTGKYLKVNSQVHTVGCdycGPLVEIARnrgcEAMVCDNLNLPFRDEGFDAIISig 109 46777774.....4556777888889***********9899999998762223455443211226789************99655411 PP ES---SS-HH..HHHHHHHHHEEEEEEEEE CS Methyltransf_8 129 clslmgtnla..dflkeanrvlkvGGllkv 156 + +t+ + +ke+ rvl +GG l++ sp|Q9P272|K1456_HUMAN 110 VIHHFSTKQRriRAIKEMARVLVPGGQLMI 139 445555555412479***********9987 PP >> sp|Q9H8H3|MET7A_HUMAN Methyltransferase-like protein 7A OS=Homo sapiens GN=METTL7A PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.3 0.0 1.4e-08 6e-05 118 158 .. 133 174 .. 118 200 .. 0.81 Alignments for each domain: == domain 1 score: 25.3 bits; conditional E-value: 1.4e-08 --TT-EEEEEEES---.SS-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 118 ledesvdvavfclslm.gtnladflkeanrvlkvGGllkvae 158 ++d+svdv+v+ l l ++n + l+e+ rvl++GG ++ e sp|Q9H8H3|MET7A_HUMAN 133 VADGSVDVVVCTLVLCsVKNQERILREVCRVLRPGGAFYFME 174 68************9736789999************999776 PP >> tr|H0YI09|H0YI09_HUMAN Methyltransferase-like protein 7A (Fragment) OS=Homo sapiens GN=METTL7A PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.3 0.0 1.4e-08 6e-05 118 158 .. 133 174 .. 118 200 .. 0.81 Alignments for each domain: == domain 1 score: 25.3 bits; conditional E-value: 1.4e-08 --TT-EEEEEEES---.SS-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 118 ledesvdvavfclslm.gtnladflkeanrvlkvGGllkvae 158 ++d+svdv+v+ l l ++n + l+e+ rvl++GG ++ e tr|H0YI09|H0YI09_HUMAN 133 VADGSVDVVVCTLVLCsVKNQERILREVCRVLRPGGAFYFME 174 68************9736789999************999776 PP >> tr|F8VQX6|F8VQX6_HUMAN Methyltransferase-like protein 7A (Fragment) OS=Homo sapiens GN=METTL7A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 24.9 0.1 1.8e-08 7.8e-05 118 158 .. 133 174 .. 117 178 .. 0.85 Alignments for each domain: == domain 1 score: 24.9 bits; conditional E-value: 1.8e-08 --TT-EEEEEEES---.SS-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 118 ledesvdvavfclslm.gtnladflkeanrvlkvGGllkvae 158 ++d+svdv+v+ l l ++n + l+e+ rvl++GG ++ e tr|F8VQX6|F8VQX6_HUMAN 133 VADGSVDVVVCTLVLCsVKNQERILREVCRVLRPGGAFYFME 174 68************9736789999*************99766 PP >> sp|Q6UX53|MET7B_HUMAN Methyltransferase-like protein 7B OS=Homo sapiens GN=METTL7B PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -2.5 0.0 4.2 1.9e+04 69 84 .. 67 82 .. 57 106 .. 0.73 2 ! 22.5 0.0 9.4e-08 0.00042 112 158 .. 129 174 .. 119 197 .. 0.85 Alignments for each domain: == domain 1 score: -2.5 bits; conditional E-value: 4.2 TS-TTS-EEEES-TT- CS Methyltransf_8 69 kkkdnlvvadlGcGea 84 +++++ +lGcG sp|Q6UX53|MET7B_HUMAN 67 GASGKVALLELGCGTG 82 5566778889999964 PP == domain 2 score: 22.5 bits; conditional E-value: 9.4e-08 -TTS-S--TT-EEEEEEES---S.S-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 112 dlakvPledesvdvavfclslmg.tnladflkeanrvlkvGGllkvae 158 d+++ l+d+s+dv+v+ l l + + ++ l+e++rvl++GG+l+ e sp|Q6UX53|MET7B_HUMAN 129 DMRQ--LADGSMDVVVCTLVLCSvQSPRKVLQEVRRVLRPGGVLFFWE 174 5555..68************9861567999************997654 PP >> sp|Q96BT7|ALKB8_HUMAN Alkylated DNA repair protein alkB homolog 8 OS=Homo sapiens GN=ALKBH8 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.4 0.0 1e-07 0.00046 57 155 .. 391 500 .. 363 518 .. 0.72 Alignments for each domain: == domain 1 score: 22.4 bits; conditional E-value: 1e-07 S-HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH--S-..E...EEEESS-S....STTEEES-TTS-S--TT-EE....EEEEES--- CS Methyltransf_8 57 enPldviirklkkkkdnlvvadlGcGeakiaeavrekekv...rsfdlvav....nervvacdlakvPledesvd....vavfclslm 133 + P +i++ lk ++ +vad+GcG+ k +e + rs +lv + + + +cd vP+ +s d +av+ sp|Q96BT7|ALKB8_HUMAN 391 HTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIgcdRSQNLVDIcrerQFQAFVCDALAVPVRSGSCDacisIAVIHHFAT 478 568889***********************88555555555333455566542111336789*********999884422333333344 PP SS-HHHHHHHHHHHEEEEEEEE CS Methyltransf_8 134 gtnladflkeanrvlkvGGllk 155 ++ l+e+ r+l++GG sp|Q96BT7|ALKB8_HUMAN 479 AERRVAALQEIVRLLRPGGKAL 500 45566789***********754 PP >> sp|Q96BT7-4|ALKB8_HUMAN Isoform 4 of Alkylated DNA repair protein alkB homolog 8 OS=Homo sapiens GN=ALKBH8 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 22.4 0.0 1e-07 0.00046 57 155 .. 394 503 .. 366 521 .. 0.72 Alignments for each domain: == domain 1 score: 22.4 bits; conditional E-value: 1e-07 S-HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH--S-..E...EEEESS-S....STTEEES-TTS-S--TT-EE....EEEEES- CS Methyltransf_8 57 enPldviirklkkkkdnlvvadlGcGeakiaeavrekekv...rsfdlvav....nervvacdlakvPledesvd....vavfcls 131 + P +i++ lk ++ +vad+GcG+ k +e + rs +lv + + + +cd vP+ +s d +av+ sp|Q96BT7-4|ALKB8_HUMAN 394 HTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIgcdRSQNLVDIcrerQFQAFVCDALAVPVRSGSCDacisIAVIHHF 479 568889***********************88555555555333455566542111336789*********9998844223333333 PP --SS-HHHHHHHHHHHEEEEEEEE CS Methyltransf_8 132 lmgtnladflkeanrvlkvGGllk 155 ++ l+e+ r+l++GG sp|Q96BT7-4|ALKB8_HUMAN 480 ATAERRVAALQEIVRLLRPGGKAL 503 4445566789***********754 PP >> sp|Q9HBK9|AS3MT_HUMAN Arsenite methyltransferase OS=Homo sapiens GN=AS3MT PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.3 0.0 2.1e-07 0.00095 78 163 .. 102 190 .. 87 201 .. 0.72 Alignments for each domain: == domain 1 score: 21.3 bits; conditional E-value: 2.1e-07 EES-TT-HHHHH--S-..EEEEESS-SSTTEEES-TTS-...S--TT-EEEEEE.ES---SS-HHHHHHHHHHHEEEEEEEEEEEEGG CS Methyltransf_8 78 dlGcGeakiaeavrekekvrsfdlvavnervvacdlakv...Pledesvdvavf.clslmgtnladflkeanrvlkvGGllkvaevks 161 d+ G++ +ae+ + +++ + ++a n + + k+ +++es d++v c+ ++ + ++ l+ea+rvlk GG l+ ++v + sp|Q9HBK9|AS3MT_HUMAN 102 DMTKGQVEVAEKYLDY-HMEKYGFQASNVTFIHGYIEKLgeaGIKNESHDIVVSnCVINLVPDKQQVLQEAYRVLKHGGELYFSDVYT 188 5555555555444443.45555556666665555555442115789*****995499999***********************99976 PP G- CS Methyltransf_8 162 rf 163 + sp|Q9HBK9|AS3MT_HUMAN 189 SL 190 65 PP >> tr|B4DP72|B4DP72_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens GN=COQ5 PE=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -3.2 0.0 7.1 3.1e+04 174 187 .. 52 65 .. 40 89 .. 0.63 2 ! 17.3 0.0 3.7e-06 0.016 112 158 .. 125 172 .. 116 192 .. 0.87 3 ? 1.4 0.0 0.27 1.2e+03 156 187 .. 210 241 .. 202 248 .. 0.81 Alignments for each domain: == domain 1 score: -3.2 bits; conditional E-value: 7.1 HCTTEEEEEEE--S CS Methyltransf_8 174 tklGfevkskdlsn 187 t++Gfe++s +++ tr|B4DP72|B4DP72_HUMAN 52 THFGFETVSEEEKG 65 56788877766553 PP == domain 2 score: 17.3 bits; conditional E-value: 3.7e-06 -TTS-S--TT-EEEEEEES---.SS-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 112 dlakvPledesvdvavfclslm.gtnladflkeanrvlkvGGllkvae 158 d ++P +d+ d+ + + + +t + + l+ea+rvlk+GG + e tr|B4DP72|B4DP72_HUMAN 125 DAEELPFDDDKFDIYTIAFGIRnVTHIDQALQEAHRVLKPGGRFLCLE 172 8889**********99999985389*****************987666 PP == domain 3 score: 1.4 bits; conditional E-value: 0.27 EEEEGGG-S-HHHHHHHHHCTTEEEEEEE--S CS Methyltransf_8 156 vaevksrfesvklfaraltklGfevkskdlsn 187 + e rf+s + f+ ++ Gf+ + + + tr|B4DP72|B4DP72_HUMAN 210 LVESIRRFPSQEEFKDMIEDAGFHKVTYESLT 241 566677*****************988776655 PP >> sp|Q5HYK3|COQ5_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens GN=COQ5 PE=1 SV # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -3.5 0.0 8.5 3.8e+04 106 115 .. 165 174 .. 163 178 .. 0.81 2 ! 16.6 0.0 6e-06 0.026 112 158 .. 199 246 .. 192 265 .. 0.87 3 ? 0.8 0.0 0.4 1.8e+03 156 187 .. 284 315 .. 278 322 .. 0.81 Alignments for each domain: == domain 1 score: -3.5 bits; conditional E-value: 8.5 TTEEES-TTS CS Methyltransf_8 106 ervvacdlak 115 +rvv+cd++k sp|Q5HYK3|COQ5_HUMAN 165 SRVVVCDINK 174 689****976 PP == domain 2 score: 16.6 bits; conditional E-value: 6e-06 -TTS-S--TT-EEEEEEES---.SS-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 112 dlakvPledesvdvavfclslm.gtnladflkeanrvlkvGGllkvae 158 d ++P +d+ d+ + + + +t + + l+ea+rvlk+GG + e sp|Q5HYK3|COQ5_HUMAN 199 DAEELPFDDDKFDIYTIAFGIRnVTHIDQALQEAHRVLKPGGRFLCLE 246 7889**********99999985389*****************987666 PP == domain 3 score: 0.8 bits; conditional E-value: 0.4 EEEEGGG-S-HHHHHHHHHCTTEEEEEEE--S CS Methyltransf_8 156 vaevksrfesvklfaraltklGfevkskdlsn 187 + e rf+s + f+ ++ Gf+ + + + sp|Q5HYK3|COQ5_HUMAN 284 LVESIRRFPSQEEFKDMIEDAGFHKVTYESLT 315 566677*****************988776555 PP >> tr|F8VVX6|F8VVX6_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (Fragment) OS=Homo sapiens GN # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -2.5 0.0 4.1 1.8e+04 106 115 .. 84 93 .. 80 99 .. 0.81 2 ! 17.7 0.0 2.8e-06 0.012 112 158 .. 118 165 .. 111 188 .. 0.87 Alignments for each domain: == domain 1 score: -2.5 bits; conditional E-value: 4.1 TTEEES-TTS CS Methyltransf_8 106 ervvacdlak 115 +rvv+cd++k tr|F8VVX6|F8VVX6_HUMAN 84 SRVVVCDINK 93 6899***976 PP == domain 2 score: 17.7 bits; conditional E-value: 2.8e-06 -TTS-S--TT-EEEEEEES---.SS-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 112 dlakvPledesvdvavfclslm.gtnladflkeanrvlkvGGllkvae 158 d ++P +d+ d+ + + + +t + + l+ea+rvlk+GG + e tr|F8VVX6|F8VVX6_HUMAN 118 DAEELPFDDDKFDIYTIAFGIRnVTHIDQALQEAHRVLKPGGRFLCLE 165 7889**********99999985389*****************987766 PP >> sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS=Homo sapiens GN=THUMPD2 PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.4 0.0 2 8.8e+03 5 48 .. 33 78 .. 30 88 .. 0.71 2 ? 13.4 0.0 5.7e-05 0.25 113 155 .. 358 405 .. 340 421 .. 0.80 Alignments for each domain: == domain 1 score: -1.4 bits; conditional E-value: 2 XX-HHHHHHHHHHHHHHHHHS-HHHHHHH..HHH-HHHHHHHHHHH CS Methyltransf_8 5 kikkrldgarfrflneklytgesskavdl..fkedpeafdlyhkgf 48 +++ rl +++ ++ k++ ++ s l +k +f l k f sp|Q9BTF0|THUM2_HUMAN 33 EVRARLAATQVEYISGKVFFTTCSDLNMLkkLKSAERLFLLIKKQF 78 6789999999999999999777765544411455666777766666 PP == domain 2 score: 13.4 bits; conditional E-value: 5.7e-05 TTS-S--TT-EEEEEEES--.....-SS-HHHHHHHHHHHEEEEEEEE CS Methyltransf_8 113 lakvPledesvdvavfclsl.....mgtnladflkeanrvlkvGGllk 155 + ++Pl esvd+++ + + +g+++++ l+e++rvl+vGG + sp|Q9BTF0|THUM2_HUMAN 358 VIELPLPSESVDIIISDIPFgkkfkLGKDIKSILQEMERVLHVGGTIV 405 4689***********887654444589******************864 PP >> sp|Q9NZJ6|COQ3_HUMAN Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial OS=Homo sapiens GN=COQ3 PE=1 SV=3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 9.2 0.0 0.0011 4.8 97 159 .. 188 253 .. 71 279 .. 0.55 Alignments for each domain: == domain 1 score: 9.2 bits; conditional E-value: 0.0011 EEEESS-SSTTEE..ES-TTS-S--.TT-EEEEEEES--.-SS-HHHHHHHHHHHEEEEEEEEEEEE CS Methyltransf_8 97 rsfdlvavnervv..acdlakvPle.desvdvavfclsl.mgtnladflkeanrvlkvGGllkvaev 159 +sfd v +++r++ +c l ++ e e+ d +v + + +l++fl+ +vlk+GG l+++ + sp|Q9NZJ6|COQ3_HUMAN 188 KSFDPV-LDKRIEyrVCSLEEIVEEtAETFDAVVASEVVeHVIDLETFLQCCCQVLKPGGSLFITTI 253 334322.233322114555443332134555444433221345666666666777777777766665 PP >> tr|B3KR61|B3KR61_HUMAN HCG1811060, isoform CRA_c OS=Homo sapiens GN=NDUFAF5 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.7 0.0 9.4e-05 0.42 77 154 .. 94 184 .. 40 189 .. 0.71 Alignments for each domain: == domain 1 score: 12.7 bits; conditional E-value: 9.4e-05 EEES-TT-HHHHH--S-....EEEEESS.....-SST.T...E.EES-TTS-S--TT-EEEEEEES---.SS-HHHHHHHHHHHEEE CS Methyltransf_8 77 adlGcGeakiaeavreke..kvrsfdlv.....avne.r...v.vacdlakvPledesvdvavfclslm.gtnladflkeanrvlkv 150 dlGcG ia+ ++++ k d++ e + v v d +P ++++ d++v lsl +++l l++++ +lk+ tr|B3KR61|B3KR61_HUMAN 94 LDLGCGRGYIAQYLNKETigKFFQADIAenalkNSSEtEiptVsVLADEEFLPFKENTFDLVVSSLSLHwVNDLPRALEQIHYILKP 180 6999999999944333221122223433111112222121112134577889****************64899************** PP EEEE CS Methyltransf_8 151 GGll 154 G++ tr|B3KR61|B3KR61_HUMAN 181 DGVF 184 9987 PP >> tr|H7C552|H7C552_HUMAN Methyltransferase-like protein 2B (Fragment) OS=Homo sapiens GN=METTL2B PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.6 0.0 0.00021 0.93 111 155 .. 5 53 .. 2 70 .. 0.81 Alignments for each domain: == domain 1 score: 11.6 bits; conditional E-value: 0.00021 S-T.TS-S--TT-EEEE..EEES---S.S-HHHHHHHHHHHEEEEEEEE CS Methyltransf_8 111 cdl.akvPledesvdva..vfclslmg.tnladflkeanrvlkvGGllk 155 cd + P+ +s d++ +f ls ++ +++++ ++ r+lk+GG++ tr|H7C552|H7C552_HUMAN 5 CDEeKSYPVPKGSLDIIilIFVLSAVVpDKMQKAINRLSRLLKPGGMVL 53 777566899999999872258899776256999*************975 PP >> sp|Q96IZ6-2|MET2A_HUMAN Isoform 2 of Methyltransferase-like protein 2A OS=Homo sapiens GN=METTL2A # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.3 0.0 0.00025 1.1 111 156 .. 105 154 .. 95 178 .. 0.83 Alignments for each domain: == domain 1 score: 11.3 bits; conditional E-value: 0.00025 S-T.TS-S--TT-EEEE..EEES---S.S-HHHHHHHHHHHEEEEEEEEE CS Methyltransf_8 111 cdl.akvPledesvdva..vfclslmg.tnladflkeanrvlkvGGllkv 156 cd + P+ +s d++ +f ls ++ +++++ ++ r+lk+GG++ + sp|Q96IZ6-2|MET2A_HUMAN 105 CDEeKSYPVPKGSLDIIilIFVLSAIVpDKMQKAINRLSRLLKPGGMMLL 154 777566899999999872268899776266999*************9865 PP >> tr|F6XBY7|F6XBY7_HUMAN Uncharacterized protein KIAA1456 OS=Homo sapiens GN=KIAA1456 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.7 0.0 0.00039 1.7 50 96 .. 27 68 .. 3 78 .. 0.73 Alignments for each domain: == domain 1 score: 10.7 bits; conditional E-value: 0.00039 HHHCTSSS-HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH--S-..E CS Methyltransf_8 50 sqvkkWPenPldviirklkkkkdnlvvadlGcGeakiaeavrekekv 96 q k WP + + l+++k +ad+GcG k + ++ + v tr|F6XBY7|F6XBY7_HUMAN 27 LQSKAWPR-----VRQFLQEQKPGSLIADIGCGTGKYLKVNSQVHTV 68 57777774.....4556777888889********9998766666665 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (219 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 1780 (0.0201191); expected 1769.5 (0.02) Passed bias filter: 1328 (0.0150102); expected 1769.5 (0.02) Passed Vit filter: 127 (0.00143547); expected 88.5 (0.001) Passed Fwd filter: 20 (0.000226058); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 20 [number of targets reported over threshold] # CPU time: 0.51u 0.03s 00:00:00.54 Elapsed: 00:00:00.23 # Mc/sec: 33393.23 // [ok]