# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Methyltransf_8.hmm.txt # target sequence database: proteomes/Pan_troglodytes.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Methyltransf_8 [M=219] Accession: PF05148.15 Description: Hypothetical methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 1.3e-105 352.5 0.0 1.6e-105 352.1 0.0 1.1 1 tr|H2Q324|H2Q324_PANTR Ribosomal RNA processing 8, methyltra 6.5e-06 26.5 0.0 1e-05 25.8 0.0 1.3 1 tr|H2REA5|H2REA5_PANTR KIAA1456 isoform 3 OS=Pan troglodytes 1.1e-05 25.7 0.0 1.9e-05 25.0 0.0 1.3 1 tr|H2Q5X3|H2Q5X3_PANTR METTL7A isoform 1 OS=Pan troglodytes 4.7e-05 23.7 0.0 0.00011 22.5 0.0 1.5 2 tr|H2Q658|H2Q658_PANTR METTL7B isoform 1 OS=Pan troglodytes 9.3e-05 22.7 0.0 0.00016 21.9 0.0 1.3 1 tr|H2R4Z9|H2R4Z9_PANTR AlkB homolog 8, tRNA methyltransferas 0.00012 22.4 0.0 0.00031 21.0 0.0 1.7 1 tr|H2Q437|H2Q437_PANTR AS3MT isoform 1 OS=Pan troglodytes OX 0.00017 21.9 0.0 0.0069 16.6 0.0 2.7 3 tr|H2Q714|H2Q714_PANTR 2-methoxy-6-polyprenyl-1,4-benzoquino ------ inclusion threshold ------ 0.012 15.9 0.0 0.065 13.4 0.0 2.1 2 tr|H2QHS9|H2QHS9_PANTR THUMP domain containing 2 OS=Pan trog 0.036 14.3 0.0 1.2 9.3 0.0 2.2 1 tr|H2QTG0|H2QTG0_PANTR Ubiquinone biosynthesis O-methyltrans Domain annotation for each sequence (and alignments): >> tr|H2Q324|H2Q324_PANTR Ribosomal RNA processing 8, methyltransferase, homolog OS=Pan troglodytes OX=9598 GN=RRP8 PE= # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 352.1 0.0 6.4e-109 1.6e-105 2 219 .] 238 456 .] 237 456 .] 0.99 Alignments for each domain: == domain 1 score: 352.1 bits; conditional E-value: 6.4e-109 XXXXX-HHHHHHHHHHHHHHHHHS-HHHHHHHHHH-HHHHHHHHHHHHHHHCTSSS-HHHHHHHHHCTS-TTS-EEEES-TT-HHHH CS Methyltransf_8 2 leakikkrldgarfrflneklytgesskavdlfkedpeafdlyhkgfrsqvkkWPenPldviirklkkkkdnlvvadlGcGeakiae 88 l+a++++rldgarfr+lne+ly+g+ss+a++lf+ dpeaf lyh+gf+sqvkkWP +P+d+i+r+l++++++lvvad+GcG++++a+ tr|H2Q324|H2Q324_PANTR 238 LRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQGDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCRLAS 324 899************************************************************************************ PP H--S-..EEEEESS-SSTTEEES-TTS-S--TT-EEEEEEES---SS-HHHHHHHHHHHEEEEEEEEEEEEGGG-S-HHHHHHHHHC CS Methyltransf_8 89 avrekekvrsfdlvavnervvacdlakvPledesvdvavfclslmgtnladflkeanrvlkvGGllkvaevksrfesvklfaraltk 175 ++r++ v++fdl+++++rv++cd+a+vPledesvdvavfclslmgtn++dfl+eanrvlk+GGllkvaev+srfe+v++f+ra+tk tr|H2Q324|H2Q324_PANTR 325 SIRNP--VHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTK 409 ****9..******************************************************************************** PP TTEEEEEEE--STTEEEEEEEE-S..SS-TT---.GG--------XX CS Methyltransf_8 176 lGfevkskdlsnkqfvlfefkkve..kkgkkrel.glklkpclykkr 219 lGf+++skdlsn++f+lf+f+k++ +g+k++l gl+l+pclyk+r tr|H2Q324|H2Q324_PANTR 410 LGFKIVSKDLSNSHFFLFDFQKTGppLVGPKAQLsGLQLQPCLYKRR 456 ***********************8889*****9989**********9 PP >> tr|H2REA5|H2REA5_PANTR KIAA1456 isoform 3 OS=Pan troglodytes OX=9598 GN=TRMT9B PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.8 0.0 4.1e-09 1e-05 50 156 .. 27 139 .. 3 169 .. 0.71 Alignments for each domain: == domain 1 score: 25.8 bits; conditional E-value: 4.1e-09 HHHCTSSS-HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH--S-..EEE...EESS-SST....TEEES-TTS-S--TT-EEEEEE. CS Methyltransf_8 50 sqvkkWPenPldviirklkkkkdnlvvadlGcGeakiaeavrekekvrs...fdlvavne....rvvacdlakvPledesvdvavf. 128 q k WP + + l+++k +ad+GcG k + ++ + v + lv + + ++cd ++P de d ++ tr|H2REA5|H2REA5_PANTR 27 LQSKAWPR-----VRQFLQEQKPGSLIADIGCGTGKYLKVNSQVHTVGCdycGPLVEIARnrgcEAMVCDNLNLPFRDEGFDAIISi 108 46777774.....4556777888889***********9899999998762223455443211226789************9965541 PP .ES---SS-HH..HHHHHHHHHEEEEEEEEE CS Methyltransf_8 129 .clslmgtnla..dflkeanrvlkvGGllkv 156 + +t+ + +ke+ rvl +GG l++ tr|H2REA5|H2REA5_PANTR 109 gVIHHFSTKQRriRAIKEMARVLVPGGQLMI 139 1445555555412479***********9987 PP >> tr|H2Q5X3|H2Q5X3_PANTR METTL7A isoform 1 OS=Pan troglodytes OX=9598 GN=METTL7A PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.0 0.0 7.6e-09 1.9e-05 118 158 .. 133 174 .. 117 192 .. 0.82 Alignments for each domain: == domain 1 score: 25.0 bits; conditional E-value: 7.6e-09 --TT-EEEEEEES---.SS-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 118 ledesvdvavfclslm.gtnladflkeanrvlkvGGllkvae 158 ++d+svdv+v+ l l ++n + l+e+ rvl++GG ++ e tr|H2Q5X3|H2Q5X3_PANTR 133 VADGSVDVVVCTLVLCsVKNQERILREVCRVLRPGGAFYFME 174 68************9736789999************999776 PP >> tr|H2Q658|H2Q658_PANTR METTL7B isoform 1 OS=Pan troglodytes OX=9598 GN=METTL7B PE=2 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -2.5 0.0 1.9 4.8e+03 69 84 .. 67 82 .. 57 106 .. 0.73 2 ! 22.5 0.0 4.2e-08 0.00011 112 158 .. 129 174 .. 119 197 .. 0.85 Alignments for each domain: == domain 1 score: -2.5 bits; conditional E-value: 1.9 TS-TTS-EEEES-TT- CS Methyltransf_8 69 kkkdnlvvadlGcGea 84 +++++ +lGcG tr|H2Q658|H2Q658_PANTR 67 GASGKVALLELGCGTG 82 5566778889999964 PP == domain 2 score: 22.5 bits; conditional E-value: 4.2e-08 -TTS-S--TT-EEEEEEES---S.S-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 112 dlakvPledesvdvavfclslmg.tnladflkeanrvlkvGGllkvae 158 d+++ l+d+s+dv+v+ l l + + ++ l+e++rvl++GG+l+ e tr|H2Q658|H2Q658_PANTR 129 DMRQ--LADGSMDVVVCTLVLCSvQSPRKVLQEVRRVLRPGGVLFFWE 174 5555..68************9861567999************997654 PP >> tr|H2R4Z9|H2R4Z9_PANTR AlkB homolog 8, tRNA methyltransferase OS=Pan troglodytes OX=9598 GN=ALKBH8 PE=4 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.9 0.0 6.3e-08 0.00016 57 155 .. 394 503 .. 366 520 .. 0.72 Alignments for each domain: == domain 1 score: 21.9 bits; conditional E-value: 6.3e-08 S-HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH--S-..E...EEEESS-S....STTEEES-TTS-S--TT-EE....EEEEES-- CS Methyltransf_8 57 enPldviirklkkkkdnlvvadlGcGeakiaeavrekekv...rsfdlvav....nervvacdlakvPledesvd....vavfclsl 132 + P +i++ lk ++ +vad+GcG+ k +e + rs +lv + + + +cd vP+ +s d +av+ tr|H2R4Z9|H2R4Z9_PANTR 394 HTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIggdRSQNLVDIcrerQFQAFVCDALAVPVRSGSCDacisIAVIHHFA 480 568889***********************87555554444333566666552111346789*********99988442233333334 PP -SS-HHHHHHHHHHHEEEEEEEE CS Methyltransf_8 133 mgtnladflkeanrvlkvGGllk 155 ++ l+e+ r+l++GG tr|H2R4Z9|H2R4Z9_PANTR 481 TAERRVAALQEIVRLLRPGGKAL 503 445566789***********754 PP >> tr|H2Q437|H2Q437_PANTR AS3MT isoform 1 OS=Pan troglodytes OX=9598 GN=AS3MT PE=4 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 21.0 0.0 1.2e-07 0.00031 96 163 .. 119 190 .. 87 201 .. 0.72 Alignments for each domain: == domain 1 score: 21.0 bits; conditional E-value: 1.2e-07 EEEEESS-SSTTEEES-TTS-...S--TT-EEEEEE.ES---SS-HHHHHHHHHHHEEEEEEEEEEEEGGG- CS Methyltransf_8 96 vrsfdlvavnervvacdlakv...Pledesvdvavf.clslmgtnladflkeanrvlkvGGllkvaevksrf 163 ++ + ++a n + + k+ +++es d++v c+ ++ + ++ l+ea+rvlk GG l+ ++v + + tr|H2Q437|H2Q437_PANTR 119 MEKYGFQASNVTFIHGYIEKLggaGIKNESHDIVVSnCVINLVPDKQQVLQEAYRVLKHGGELYFSDVYTSL 190 5555555666555655555552224789*****995499999***********************9997665 PP >> tr|H2Q714|H2Q714_PANTR 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Pan troglodytes OX=9598 GN # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -3.5 0.0 3.8 9.8e+03 106 115 .. 165 174 .. 163 178 .. 0.81 2 ! 16.6 0.0 2.7e-06 0.0069 112 158 .. 199 246 .. 192 265 .. 0.87 3 ? 1.9 0.0 0.086 2.2e+02 156 187 .. 284 315 .. 278 322 .. 0.81 Alignments for each domain: == domain 1 score: -3.5 bits; conditional E-value: 3.8 TTEEES-TTS CS Methyltransf_8 106 ervvacdlak 115 +rvv+cd++k tr|H2Q714|H2Q714_PANTR 165 SRVVVCDINK 174 689****976 PP == domain 2 score: 16.6 bits; conditional E-value: 2.7e-06 -TTS-S--TT-EEEEEEES---.SS-HHHHHHHHHHHEEEEEEEEEEE CS Methyltransf_8 112 dlakvPledesvdvavfclslm.gtnladflkeanrvlkvGGllkvae 158 d ++P +d+ d+ + + + +t + + l+ea+rvlk+GG + e tr|H2Q714|H2Q714_PANTR 199 DAEELPFDDDKFDIYTIAFGIRnVTHIDQALQEAHRVLKPGGRFLCLE 246 7889**********99999985389*****************987666 PP == domain 3 score: 1.9 bits; conditional E-value: 0.086 EEEEGGG-S-HHHHHHHHHCTTEEEEEEE--S CS Methyltransf_8 156 vaevksrfesvklfaraltklGfevkskdlsn 187 + e rf+s + f++ ++ Gf+ + + + tr|H2Q714|H2Q714_PANTR 284 LVESIRRFPSQEEFKEMIEDAGFHKVTYESLT 315 566677*****************988776655 PP >> tr|H2QHS9|H2QHS9_PANTR THUMP domain containing 2 OS=Pan troglodytes OX=9598 GN=THUMPD2 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.1 0.0 0.7 1.8e+03 4 48 .. 32 78 .. 30 90 .. 0.72 2 ? 13.4 0.0 2.5e-05 0.065 113 155 .. 358 405 .. 340 421 .. 0.80 Alignments for each domain: == domain 1 score: -1.1 bits; conditional E-value: 0.7 XXX-HHHHHHHHHHHHHHHHHS-HHHHHHH..HHH-HHHHHHHHHHH CS Methyltransf_8 4 akikkrldgarfrflneklytgesskavdl..fkedpeafdlyhkgf 48 ++++ rl +++ ++ k++ ++ s l +k +f l k f tr|H2QHS9|H2QHS9_PANTR 32 REVRARLAATQVEYISGKVFFTTCSDLNMLkkLKSAERLFLLIKKQF 78 67889999********9999877765544411455666777776666 PP == domain 2 score: 13.4 bits; conditional E-value: 2.5e-05 TTS-S--TT-EEEEEEES--.....-SS-HHHHHHHHHHHEEEEEEEE CS Methyltransf_8 113 lakvPledesvdvavfclsl.....mgtnladflkeanrvlkvGGllk 155 + ++Pl esvd+++ + + +g+++++ l+e++rvl+vGG + tr|H2QHS9|H2QHS9_PANTR 358 VIELPLPSESVDIIISDIPFgkkfkLGKDIKSILQEMERVLHVGGTIV 405 4689***********887654444589******************864 PP >> tr|H2QTG0|H2QTG0_PANTR Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Pan troglodytes OX=9598 GN=COQ3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 9.3 0.0 0.00048 1.2 74 139 .. 148 214 .. 71 272 .. 0.51 Alignments for each domain: == domain 1 score: 9.3 bits; conditional E-value: 0.00048 S-EEEES-TT-HHHHH--S-...EEEEESS-SSTTEEES-TTS-S--TT-EEEEEEES---SS-HHH CS Methyltransf_8 74 lvvadlGcGeakiaeavrek.ekvrsfdlvavnervvacdlakvPledesvdvavfclslmgtnlad 139 + + d+GcG ++e ++ v+ +d v n + c + P+ d+ ++ v+ l ++++ a+ tr|H2QTG0|H2QTG0_PANTR 148 MKILDVGCGGGLLTEPLGRLgASVIGIDPVDENIKTAQCHKSFDPVLDKRIEYRVCSLEEIVEETAE 214 4566666666666654444313455555555555555555555555555555555555444443322 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (219 nodes) Target sequences: 23008 (11942255 residues searched) Passed MSV filter: 496 (0.0215577); expected 460.2 (0.02) Passed bias filter: 369 (0.0160379); expected 460.2 (0.02) Passed Vit filter: 37 (0.00160814); expected 23.0 (0.001) Passed Fwd filter: 9 (0.000391168); expected 0.2 (1e-05) Initial search space (Z): 23008 [actual number of targets] Domain search space (domZ): 9 [number of targets reported over threshold] # CPU time: 0.20u 0.01s 00:00:00.21 Elapsed: 00:00:00.09 # Mc/sec: 29059.49 // [ok]