# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Methyltransf_8.hmm.txt
# target sequence database: proteomes/Trypanosoma_brucei.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Methyltransf_8 [M=219]
Accession: PF05148.15
Description: Hypothetical methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
2.5e-53 180.1 0.0 3.3e-53 179.7 0.0 1.1 1 tr|Q4GZA6|Q4GZA6_TRYB2 Uncharacterized protein OS=Trypanosom
0.0006 18.7 0.0 0.73 8.6 0.0 2.2 2 tr|Q57XQ9|Q57XQ9_TRYB2 Uncharacterized protein OS=Trypanosom
0.008 15.0 0.0 0.021 13.6 0.0 1.7 2 tr|Q383M8|Q383M8_TRYB2 2-methoxy-6-polyprenyl-1,4-benzoquino
0.0088 14.9 0.0 0.016 14.0 0.0 1.4 1 tr|Q387X1|Q387X1_TRYB2 Uncharacterized protein OS=Trypanosom
------ inclusion threshold ------
0.036 12.9 0.0 0.072 11.9 0.0 1.6 2 tr|Q385L0|Q385L0_TRYB2 Uncharacterized protein OS=Trypanosom
Domain annotation for each sequence (and alignments):
>> tr|Q4GZA6|Q4GZA6_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=TB
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 179.7 0.0 1.9e-56 3.3e-53 4 219 .] 132 369 .] 129 369 .] 0.93
Alignments for each domain:
== domain 1 score: 179.7 bits; conditional E-value: 1.9e-56
XXX-HHHHHHHHHHHHHHHHHS-HHHHHHHHHH-HHHHHHHHHHHHHHHCTSSS-HHHHHHHHHC.................TS-TT CS
Methyltransf_8 4 akikkrldgarfrflneklytgesskavdlfkedpeafdlyhkgfrsqvkkWPenPldviirklk.................kkkdn 73
++ + +l ++ fr+lne++y+++ s +l dp+ + yh+g+r+q+++WP +P dvi++ l +++
tr|Q4GZA6|Q4GZA6_TRYB2 132 EHFRTKLSASTFRLLNEQIYNSPISSVAEL-LRDPSTYADYHNGYRQQIQQWPIKPYDVILQALLedrrgrfvankaksmpgYIPSS 217
567899*****************9999999.569*****************************98899*******999888888999 PP
S-EEEES-TT-HHHHH--.S-..EEEEESS-SSTTEEES-TTS-S--TT-EEEEEEES---SS-HHHHHHHHHHHEEEEEEEEEEEE CS
Methyltransf_8 74 lvvadlGcGeakiaeavr.ekekvrsfdlvavnervvacdlakvPledesvdvavfclslmgtnladflkeanrvlkvGGllkvaev 159
v+ad+GcG+a++a+a + v+sfdl+a+ne v++ ++a+vPle +svd+ +f lslm+t++ + l ea r+lk+ llk+ ev
tr|Q4GZA6|Q4GZA6_TRYB2 218 WVIADMGCGDAQVAQALCpKGYTVHSFDLHAMNEYVTVANIAHVPLEKKSVDICIFSLSLMSTDYIKCLYEAFRILKPKRLLKIVEV 304
**************876516689**************************************************************** PP
GGG-S-HHHHHHHHHCTTEEEEEEE--STTEEEEEEEE-S.....SS-TT---GG--------XX CS
Methyltransf_8 160 ksrfesvklfaraltklGfevkskdlsnkqfvlfefkkve.....kkgkkrelglklkpclykkr 219
+sr++ + fa+ ++ +Gf + +d ++fv ++f k + ++ +k +++ l+p lykkr
tr|Q4GZA6|Q4GZA6_TRYB2 305 RSRVPHPRRFAELVEGIGFTLDYHDTVGDYFVAYDFIKLDgqesaNQHPKYDPQEVLVPSLYKKR 369
************************************99985544345566667889********9 PP
>> tr|Q57XQ9|Q57XQ9_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 8.6 0.0 0.00043 0.73 63 110 .. 33 80 .. 18 105 .. 0.84
2 ! 8.1 0.0 0.00061 1 135 190 .. 138 191 .. 123 193 .. 0.84
Alignments for each domain:
== domain 1 score: 8.6 bits; conditional E-value: 0.00043
HHHHHCTS-TTS-EEEES-TT-HHHHH--S-..EEEEESS-SSTTEEE CS
Methyltransf_8 63 iirklkkkkdnlvvadlGcGeakiaeavrekekvrsfdlvavnervva 110
++r + + +++ v +GcG+++++ + e+ +vr + v v + v++
tr|Q57XQ9|Q57XQ9_TRYB2 33 VLRPMLQPAEQIHVLVVGCGNSRLSPCMYEHLNVRKITNVDVSPTVIS 80
56666677889999*********************9999999999887 PP
== domain 2 score: 8.1 bits; conditional E-value: 0.00061
S-HHHHHHHHHHHEEEEEEEEEEEEGGG-S-HHHHHHHHHCTTEEEEEEE--STTE CS
Methyltransf_8 135 tnladflkeanrvlkvGGllkvaevksrfesvklfaraltklGfevkskdlsnkqf 190
nl++ +k+ rv+k+GG + + + ++ f r kl f+v+++ ++++ f
tr|Q57XQ9|Q57XQ9_TRYB2 138 HNLYTLTKNLARVMKNGGRFLSVSYGAPETRIDHFRR--RKLNFDVEHRTIEKSVF 191
69999*************9887666666667777777..699******99999888 PP
>> tr|Q383M8|Q383M8_TRYB2 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Trypanosoma brucei brucei
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 13.6 0.0 1.2e-05 0.021 116 166 .. 134 185 .. 127 211 .. 0.71
2 ? -1.6 0.0 0.56 9.5e+02 140 184 .. 197 242 .. 184 266 .. 0.75
Alignments for each domain:
== domain 1 score: 13.6 bits; conditional E-value: 1.2e-05
-S--TT-EEEEEEES---S.S-HHHHHHHHHHHEEEEEEEEEEEEGGG-S-H CS
Methyltransf_8 116 vPledesvdvavfclslmg.tnladflkeanrvlkvGGllkvaevksrfesv 166
+Pl+d d + + l + + l+ea+rvlkvGG+l v e + s
tr|Q383M8|Q383M8_TRYB2 134 LPLDDMQFDGYTVSFGLRNfSDRPKALREAHRVLKVGGVLSVLEFSKVTCSL 185
677777777555444443314556789***************9987655555 PP
== domain 2 score: -1.6 bits; conditional E-value: 0.56
HHHHHHHHEEEEEEE.EEEEEGGG-S-HHHHHHHHHCTTEEEEEEE CS
Methyltransf_8 140 flkeanrvlkvGGll.kvaevksrfesvklfaraltklGfevkskd 184
f+ +a r+l + + ++ + f++ +++a+ + + Gf + d
tr|Q383M8|Q383M8_TRYB2 197 FIPQAGRILANEESYrYLVDSIRAFPDQETLAEMIREAGFGYVRYD 242
6667777776654331444544568899999999999999776555 PP
>> tr|Q387X1|Q387X1_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.0 0.0 9.3e-06 0.016 118 155 .. 130 168 .. 97 172 .. 0.82
Alignments for each domain:
== domain 1 score: 14.0 bits; conditional E-value: 9.3e-06
--TT-EEEEEEES---.SS-HHHHHHHHHHHEEEEEEEE CS
Methyltransf_8 118 ledesvdvavfclslm.gtnladflkeanrvlkvGGllk 155
+ + +vd++v cls+ +++l++ + ++++vlk+ G+l+
tr|Q387X1|Q387X1_TRYB2 130 IPERTVDMVVSCLSMHwVNDLETAMVNIRKVLKKDGFLM 168
56889**********64899**************99885 PP
>> tr|Q385L0|Q385L0_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.2 0.0 1.8 3e+03 78 86 .. 82 90 .. 72 104 .. 0.74
2 ? 11.9 0.0 4.2e-05 0.072 58 99 .. 161 202 .. 117 235 .. 0.80
Alignments for each domain:
== domain 1 score: -3.2 bits; conditional E-value: 1.8
EES-TT-HH CS
Methyltransf_8 78 dlGcGeaki 86
+GcGea
tr|Q385L0|Q385L0_TRYB2 82 RVGCGEATA 90
479999864 PP
== domain 2 score: 11.9 bits; conditional E-value: 4.2e-05
-HHHHHHHHHCTS-TTS-EEEES-TT-HHHHH--S-..EEEE CS
Methyltransf_8 58 nPldviirklkkkkdnlvvadlGcGeakiaeavrekekvrsf 99
n +d + + k+k ++vad+GcG +i+ +++ v ++
tr|Q385L0|Q385L0_TRYB2 161 NVMDGFENGQKSKSVTIAVADFGCGTGRISCMLSRHSAVGAL 202
5566667777899999**************888777766544 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (219 nodes)
Target sequences: 8561 (4332363 residues searched)
Passed MSV filter: 193 (0.0225441); expected 171.2 (0.02)
Passed bias filter: 159 (0.0185726); expected 171.2 (0.02)
Passed Vit filter: 16 (0.00186894); expected 8.6 (0.001)
Passed Fwd filter: 5 (0.000584044); expected 0.1 (1e-05)
Initial search space (Z): 8561 [actual number of targets]
Domain search space (domZ): 5 [number of targets reported over threshold]
# CPU time: 0.07u 0.00s 00:00:00.07 Elapsed: 00:00:00.04
# Mc/sec: 23719.69
//
[ok]