# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/Pox_MCEL.hmm.txt
# target sequence database: proteomes/Trypanosoma_brucei.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Pox_MCEL [M=333]
Accession: PF03291.15
Description: mRNA capping enzyme
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
1.3e-45 155.0 0.0 1.9e-45 154.3 0.0 1.2 1 tr|Q57V03|Q57V03_TRYB2 Methyltransferase, putative OS=Trypan
9e-35 119.3 0.2 8.8e-26 89.7 0.1 2.1 2 tr|Q4FKP8|Q4FKP8_TRYB2 mRNA capping methyltransferase, putat
4.1e-10 38.2 0.0 6.7e-10 37.5 0.0 1.2 1 tr|Q384Z7|Q384Z7_TRYB2 Uncharacterized protein OS=Trypanosom
0.0063 14.6 0.0 0.019 13.0 0.0 1.7 1 tr|Q38DV8|Q38DV8_TRYB2 Ubiquinone biosynthesis O-methyltrans
------ inclusion threshold ------
0.012 13.7 0.0 0.021 12.9 0.0 1.3 1 tr|Q389Z0|Q389Z0_TRYB2 Uncharacterized protein OS=Trypanosom
0.094 10.7 0.0 0.13 10.3 0.0 1.1 1 tr|Q4GZF2|Q4GZF2_TRYB2 Histone-lysine N-methyltransferase, H
Domain annotation for each sequence (and alignments):
>> tr|Q57V03|Q57V03_TRYB2 Methyltransferase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 G
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 154.3 0.0 1.4e-48 1.9e-45 14 332 .. 730 1049 .. 720 1050 .] 0.80
Alignments for each domain:
== domain 1 score: 154.3 bits; conditional E-value: 1.4e-48
Pox_MCEL 14 vathynerpetgellkkRiastiiylrnlnNyiKslLise...yasktkl...desnklkvLdldcgkGgDLeKyekgeIsklva 92
v++hy+ ++++ + k+R lr++nN+iK +Lis+ y++ +++ +++ + v dl+ g+GgDL+K+++ + + l
tr|Q57V03|Q57V03_TRYB2 730 VNAHYACKTKELSTGKNR-----SILRHYNNWIKGVLISTsvsYLRSNNKggeFDNDGMVVADLCSGRGGDLHKWRAHQPKLLFM 809
566666666644333333.....3699************7222444444333235678999************************ PP
Pox_MCEL 93 tDiaeesieeckeRY..........nklrsekkskyykFda..elirsdsfvssvrevfed..yelkfdivslQFaiHYsFesee 163
tD e+++e+ RY ++ + +F + + s v++++e +++ +k+d+vs+QF+iHY ee
tr|Q57V03|Q57V03_TRYB2 810 TDCCLEAVAEAAARYsitkglsikvVPHDKNPPGIRAQFCVldVFDEKGSLVTKLEEFLKQchDGGKLDVVSCQFSIHYGCSNEE 894
***************998887754312222222344566666566667788888888888866679******************* PP
Pox_MCEL 164 kartvlrNvaellasGGkvlgTtpdgdelskltvkklkviekdlpsfgNsiyvvkfeeekievplfGakYeynledvvkdvpEyi 248
++r+ l v+ +l+sGG ++gTt++ el ++l++ fgN iy+v+f ++ + + fG++Y+ + e+ v+++pEy+
tr|Q57V03|Q57V03_TRYB2 895 RVRVFLSAVSSTLKSGGIFIGTTVSDTEL----LRRLRQY---GTTFGNGIYTVRFPTDAVPNDSFGVEYSVSFESSVSEMPEYL 972
************************99999....7888888...599*************************************** PP
Pox_MCEL 249 vkfealvklaeeYgleLvdkkdfaeiieesikkelkklikrvskleerkstknfeelnrsalkstlgkdeeealsyYlvfvfeK 332
v+ + +v+l+ Y+l+Lv+ f e+ + + ++++l ++++ s + + +l+ l+ de ea+ ++ +f f K
tr|Q57V03|Q57V03_TRYB2 973 VPWNRFVNLCGAYNLQLVESFGFVEYGDMH---YNSALGQELR----DASMNGGRRDSDGHLRLRLSPDEAEAAGLFRTFLFVK 1049
***********************9998887...4567777776....2233333444555666678899999999999988877 PP
>> tr|Q4FKP8|Q4FKP8_TRYB2 mRNA capping methyltransferase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 27.7 0.0 4.4e-10 6.3e-07 33 84 .. 34 86 .. 5 93 .. 0.78
2 ! 89.7 0.1 6.1e-29 8.8e-26 92 280 .. 112 294 .. 97 315 .. 0.77
Alignments for each domain:
== domain 1 score: 27.7 bits; conditional E-value: 4.4e-10
Pox_MCEL 33 astiiylrnlnNyiKslLiseyasktklde.snklkvLdldcgkGgDLeKyek 84
+s+ +r ++Ny+K Li+ + + k + ++ vLdl+ g+GgDL K+
tr|Q4FKP8|Q4FKP8_TRYB2 34 KSKETPFRFFSNYVKKCLIQCALDHIKVTTgRRDAIVLDLASGRGGDLGKWLH 86
444445566****************99955156788***************65 PP
== domain 2 score: 89.7 bits; conditional E-value: 6.1e-29
Pox_MCEL 92 atDiaeesieeckeRYnklrsekkskyykFdaelirsdsfvs..svrev.fedyelkfdivslQFaiHYsFeseekartvlrNvael 175
+ D++ e i+e++ RY+k + + d+f++ +re+ + + ++kfdivs+QFa+HY+ ++ e+ +++l +a+
tr|Q4FKP8|Q4FKP8_TRYB2 112 CYDVSPECIAEAESRYKKIAPDTVC-----RCSFTVKDCFSEdfLLRELpLTQHFGKFDIVSIQFAFHYACDTLERIDMLLGAIARA 193
89**************777666655.....345555666665223566435679********************************* PP
Pox_MCEL 176 lasGGkvlgTtpdgdelskltvkklkviekdlpsfgNsiyvvkfeeekievplfGakYeynledvvkdvpEyivkfealvklaeeYg 262
la+ G++++Tt+d ++l+k++ ++ k+l s+ + + +fe ++ v G++Y++nl++ v d+ Ey+v+ + ++ a++ g
tr|Q4FKP8|Q4FKP8_TRYB2 194 LAPEGVFIATTVDEEVLAKRVAA-NRMESKGLFSIHFD-SEPQFEYDRLVV---GTRYRFNLDGFV-DCDEYVVPLDYVRDCAKQHG 274
*****************443332.23333455444444.444555555555...************.******************** PP
Pox_MCEL 263 le..Lvdkkdfaeiieesik 280
le k+f ++e + +
tr|Q4FKP8|Q4FKP8_TRYB2 275 LEemVKFSKHFGSFYETYKD 294
*8433457899999998744 PP
>> tr|Q384Z7|Q384Z7_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 37.5 0.0 4.7e-13 6.7e-10 48 192 .. 803 940 .. 799 1025 .. 0.74
Alignments for each domain:
== domain 1 score: 37.5 bits; conditional E-value: 4.7e-13
Pox_MCEL 48 slLiseyasktkldesnklkvLdldcgkGgDLeKyekgeIsklvatDiaeesieeckeRYnklrsekkskyykFda...elirsdsf 131
slLi+ ++ k+ + vL+++cg G L+K+ + +++++ D ++ ++e +lr e ++ +d+ ++ ++
tr|Q384Z7|Q384Z7_TRYB2 803 SLLIDIITPKVAT-----NDVLEICCG-GYLLRKWIRNKTARYIGFDLKSSVVDAASELISSLRHEMTEM-SFYDVicaDVFSANFW 882
5677777777666.....68******9.899***************************997777666554.2233322345555555 PP
Pox_MCEL 132 vssvrevfedyelkfdivslQFaiHYsFeseekartvlrNvaellasGGkvlgTtpdgdel 192
+++++++ +f ++ + +H +F +e a ++++ va+ l +GG+++g d + l
tr|Q384Z7|Q384Z7_TRYB2 883 SHHLTKIH---PRQFHVITAFAGFHHAFGTEYTAMRLIESVANALIPGGVFIGCFFDVEPL 940
55555555...689****99999*******************************9998887 PP
>> tr|Q38DV8|Q38DV8_TRYB2 Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Trypanosoma brucei brucei (stra
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 13.0 0.0 1.4e-05 0.019 66 192 .. 68 181 .. 58 192 .. 0.76
Alignments for each domain:
== domain 1 score: 13.0 bits; conditional E-value: 1.4e-05
Pox_MCEL 66 lkvLdldcgkGgDLeKyekgeIsklvatDiaeesieeckeRYnklrsekkskyykFdaelirsdsfvssvrevfedyelkfdivslQ 152
++vLd++cg Gg L + +++D+ +esi+ ++eR ++ ++++ + + +r+ ++ev+e +f++v +
tr|Q38DV8|Q38DV8_TRYB2 68 MSVLDVGCG-GGILSESIARLGGDVLGIDMCKESIAVAEERRQRVLRDITPQ----ASLAYRCV----PLHEVVEGEGRQFELVVAS 145
689999999.5556665555556789***************97777777764....33455554....5677777778899998877 PP
Pox_MCEL 153 FaiHYsFeseekartvlrNvaellasGGkvlgTtpdgdel 192
+i a l+ +++ +++GG++++ t+d +
tr|Q38DV8|Q38DV8_TRYB2 146 EVIEH----VSDAAAFLHDICAATKPGGVLVISTMDKSLF 181
77642....233447********************98766 PP
>> tr|Q389Z0|Q389Z0_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.9 0.0 1.5e-05 0.021 49 133 .. 196 274 .. 191 292 .. 0.76
Alignments for each domain:
== domain 1 score: 12.9 bits; conditional E-value: 1.5e-05
Pox_MCEL 49 lLiseyasktkldesnklkvLdldcgkGgDLeKy.ekgeIsklvatDiaeesieeckeRYnklrsekkskyykFdaelirsdsfvs 133
L+ +++sk + +++ l+vLd++cg G + + ++ a+Di +e+i ++e kl+ ++s ++++sd f+s
tr|Q389Z0|Q389Z0_TRYB2 196 WLVRTWLSKIPE-TTQPLRVLDMCCGTGCVGIAIaKHVPSAQVTAVDILDEAIGASEENA-KLNGLEASR-----FCTLKSDMFES 274
58999******9.9**************865544045566788899*******9988865.555555553.....35555555555 PP
>> tr|Q4GZF2|Q4GZF2_TRYB2 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Trypanosoma brucei brucei (strai
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.3 0.0 8.9e-05 0.13 65 139 .. 112 187 .. 102 212 .. 0.76
Alignments for each domain:
== domain 1 score: 10.3 bits; conditional E-value: 8.9e-05
Pox_MCEL 65 klkvLdldcgkGgDLeKyekgeIsklvatDiaeesieeckeRYnklrse.kkskyykFdaelirsdsfvssvrevf 139
+ ++ dl+cg+G+ L + ++ v++ i+e+ + +ke +++lr +k+ k d+ ++++d ++ ++ +
tr|Q4GZF2|Q4GZF2_TRYB2 112 DDTFYDLGCGNGSVLFHVALATGASCVGVEINEHNAKVAKEAWTHLRPVfEKRRGRKLDVSIVCGDFCKVLKQDNY 187
55788**************************************888865145556799999999997766655555 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (333 nodes)
Target sequences: 8561 (4332363 residues searched)
Passed MSV filter: 271 (0.0316552); expected 171.2 (0.02)
Passed bias filter: 177 (0.0206752); expected 171.2 (0.02)
Passed Vit filter: 14 (0.00163532); expected 8.6 (0.001)
Passed Fwd filter: 6 (0.000700853); expected 0.1 (1e-05)
Initial search space (Z): 8561 [actual number of targets]
Domain search space (domZ): 6 [number of targets reported over threshold]
# CPU time: 0.11u 0.01s 00:00:00.12 Elapsed: 00:00:00.04
# Mc/sec: 36066.92
//
[ok]