# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/Rsm22.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: Rsm22 [M=275] Accession: PF09243.9 Description: Mitochondrial small ribosomal subunit Rsm22 Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 3.6e-60 205.9 0.0 4.5e-60 205.5 0.0 1.1 1 sp|Q9H7H0|MET17_HUMAN Methyltransferase-like protein 17, m 2.3e-53 183.5 0.0 2.9e-53 183.2 0.0 1.1 1 sp|Q9H7H0-2|MET17_HUMAN Isoform 2 of Methyltransferase-like 4.3e-53 182.6 0.0 6e-53 182.2 0.0 1.1 1 sp|Q9H7H0-3|MET17_HUMAN Isoform 3 of Methyltransferase-like 7e-17 63.9 0.0 9.2e-17 63.5 0.0 1.2 1 tr|G3V353|G3V353_HUMAN Methyltransferase-like protein 17, m 8.7e-17 63.6 1.3 1.1e-16 63.3 1.3 1.1 1 tr|H0YJW1|H0YJW1_HUMAN Methyltransferase-like protein 17, m 4.3e-14 54.7 0.0 5.9e-14 54.3 0.0 1.2 1 tr|G3V3X6|G3V3X6_HUMAN Methyltransferase-like protein 17, m ------ inclusion threshold ------ 0.47 12.0 0.0 0.72 11.4 0.0 1.3 1 tr|G3V4P2|G3V4P2_HUMAN Methyltransferase-like protein 17, m Domain annotation for each sequence (and alignments): >> sp|Q9H7H0|MET17_HUMAN Methyltransferase-like protein 17, mitochondrial OS=Homo sapiens GN=METTL17 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 205.5 0.0 3.6e-64 4.5e-60 4 275 .] 155 438 .. 152 438 .. 0.93 Alignments for each domain: == domain 1 score: 205.5 bits; conditional E-value: 3.6e-64 Rsm22 4 siaYalarlpatyavlrrvLdelaervpdflPkslldvgegpgtalwaaselwe.eleevlvidaseelleiskelaadapelkeaal 90 s++Y++arl + +a++ r+ +e+++r p f+P++l+d+g+g+g ++waa+ +w +l+e++ +d+s+++l ++++l++ e e sp|Q9H7H0|MET17_HUMAN 155 SLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGqSLREYMCVDRSAAMLVLAEKLLKGGSESGEPYI 242 789***************************************************99******************************** PP Rsm22 91 rrsvirealeleea...dLviisyvLleled.esreklvknlWakaskilvivEeGtpaGfrrvleaReal.........kaagfhiv 165 ++ r+ l + ++ d+v+ ++ L el ++r+++v+ lW+k+ + lv+vE+Gt+aG+ ++++aR+ + + + + sp|Q9H7H0|MET17_HUMAN 243 PGVFFRQFLPVSPKvqfDVVVSAFSLSELPSkADRTEVVQTLWRKTGHFLVLVENGTKAGHSLLMDARDLVlkgkeksplDPRPGFVF 330 *****99999999899*************999*************************************98898776666567789** PP Rsm22 166 APCPHeaaCPlvatedwChFsqrvaRlslhrlaksasvpvedekfsy..vakerqprasaaaRvvrptkvrskkvlidlCsedetlqr 251 APCPHe+ CP +++ C Fsq ++ k +ekfs +a+++ ++a+ ++R+ +p +r ++v ++lC d+++q+ sp|Q9H7H0|MET17_HUMAN 331 APCPHELPCPQLTN-LACSFSQAYHPIPFSWNKKP-----KEEKFSMviLARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDGHMQH 412 **********9999.89*******98887776664.....689****6455555556666**************************** PP Rsm22 252 lvvtK.rkG.eaykaArkaeWGDrlp 275 v+t r+G ++y++Ar+++WGD+lp sp|Q9H7H0|MET17_HUMAN 413 AVLTArRHGrDLYRCARVSSWGDLLP 438 ****989**999***********985 PP >> sp|Q9H7H0-2|MET17_HUMAN Isoform 2 of Methyltransferase-like protein 17, mitochondrial OS=Homo sapiens GN=METTL17 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 183.2 0.0 2.3e-57 2.9e-53 4 262 .. 155 424 .. 152 429 .. 0.92 Alignments for each domain: == domain 1 score: 183.2 bits; conditional E-value: 2.3e-57 Rsm22 4 siaYalarlpatyavlrrvLdelaervpdflPkslldvgegpgtalwaaselwe.eleevlvidaseelleiskelaadapelkea 88 s++Y++arl + +a++ r+ +e+++r p f+P++l+d+g+g+g ++waa+ +w +l+e++ +d+s+++l ++++l++ e e sp|Q9H7H0-2|MET17_HUMAN 155 SLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGqSLREYMCVDRSAAMLVLAEKLLKGGSESGEP 240 789***************************************************99****************************** PP Rsm22 89 alrrsvirealeleea...dLviisyvLleled.esreklvknlWakaskilvivEeGtpaGfrrvleaReal.........kaag 161 ++ r+ l + ++ d+v+ ++ L el ++r+++v+ lW+k+ + lv+vE+Gt+aG+ ++++aR+ + + sp|Q9H7H0-2|MET17_HUMAN 241 YIPGVFFRQFLPVSPKvqfDVVVSAFSLSELPSkADRTEVVQTLWRKTGHFLVLVENGTKAGHSLLMDARDLVlkgkeksplDPRP 326 *******99999999899*************999*************************************988987766665677 PP Rsm22 162 fhivAPCPHeaaCPlvatedwChFsqrvaRlslhrlaksasvpvedekfsy..vakerqprasaaaRvvrptkvrskkvlidlCse 245 + + APCPHe+ CP +++ C Fsq ++ k +ekfs +a+++ ++a+ ++R+ +p +r ++v ++lC sp|Q9H7H0-2|MET17_HUMAN 327 GFVFAPCPHELPCPQLTN-LACSFSQAYHPIPFSWNKKP-----KEEKFSMviLARGSPEEAHRWPRITQPVLKRPRHVHCHLCCP 406 89************9999.89*******98887776664.....689****6455555556666********************** PP Rsm22 246 detlqrlvvtK.rkGeay 262 d+++q+ v+t r+G+ + sp|Q9H7H0-2|MET17_HUMAN 407 DGHMQHAVLTArRHGSSW 424 **********989*9864 PP >> sp|Q9H7H0-3|MET17_HUMAN Isoform 3 of Methyltransferase-like protein 17, mitochondrial OS=Homo sapiens GN=METTL17 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 182.2 0.0 4.8e-57 6e-53 4 260 .. 155 422 .. 152 432 .. 0.91 Alignments for each domain: == domain 1 score: 182.2 bits; conditional E-value: 4.8e-57 Rsm22 4 siaYalarlpatyavlrrvLdelaervpdflPkslldvgegpgtalwaaselwe.eleevlvidaseelleiskelaadapelkea 88 s++Y++arl + +a++ r+ +e+++r p f+P++l+d+g+g+g ++waa+ +w +l+e++ +d+s+++l ++++l++ e e sp|Q9H7H0-3|MET17_HUMAN 155 SLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGqSLREYMCVDRSAAMLVLAEKLLKGGSESGEP 240 789***************************************************99****************************** PP Rsm22 89 alrrsvirealeleea...dLviisyvLleled.esreklvknlWakaskilvivEeGtpaGfrrvleaReal.........kaag 161 ++ r+ l + ++ d+v+ ++ L el ++r+++v+ lW+k+ + lv+vE+Gt+aG+ ++++aR+ + + sp|Q9H7H0-3|MET17_HUMAN 241 YIPGVFFRQFLPVSPKvqfDVVVSAFSLSELPSkADRTEVVQTLWRKTGHFLVLVENGTKAGHSLLMDARDLVlkgkeksplDPRP 326 *******99999999899*************999*************************************988987766665677 PP Rsm22 162 fhivAPCPHeaaCPlvatedwChFsqrvaRlslhrlaksasvpvedekfsy..vakerqprasaaaRvvrptkvrskkvlidlCse 245 + + APCPHe+ CP +++ C Fsq ++ k +ekfs +a+++ ++a+ ++R+ +p +r ++v ++lC sp|Q9H7H0-3|MET17_HUMAN 327 GFVFAPCPHELPCPQLTN-LACSFSQAYHPIPFSWNKKP-----KEEKFSMviLARGSPEEAHRWPRITQPVLKRPRHVHCHLCCP 406 89************9999.89*******98887776664.....689****6455555556666********************** PP Rsm22 246 detlqrlvvtK.rkGe 260 d+++q+ v+t r+G sp|Q9H7H0-3|MET17_HUMAN 407 DGHMQHAVLTArRHGR 422 **********978885 PP >> tr|G3V353|G3V353_HUMAN Methyltransferase-like protein 17, mitochondrial (Fragment) OS=Homo sapiens GN=METTL17 PE=2 S # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 63.5 0.0 7.2e-21 9.2e-17 4 84 .. 73 154 .. 70 172 .. 0.93 Alignments for each domain: == domain 1 score: 63.5 bits; conditional E-value: 7.2e-21 Rsm22 4 siaYalarlpatyavlrrvLdelaervpdflPkslldvgegpgtalwaaselwe.eleevlvidaseelleiskelaadape 84 s++Y++arl + +a++ r+ +e+++r p f+P++l+d+g+g+g ++waa+ +w +l+e++ +d+s+++l ++++l++ e tr|G3V353|G3V353_HUMAN 73 SLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGqSLREYMCVDRSAAMLVLAEKLLKGGSE 154 789***************************************************99*******************9987655 PP >> tr|H0YJW1|H0YJW1_HUMAN Methyltransferase-like protein 17, mitochondrial (Fragment) OS=Homo sapiens GN=METTL17 PE=4 S # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 63.3 1.3 8.4e-21 1.1e-16 163 262 .. 4 100 .. 2 105 .. 0.85 Alignments for each domain: == domain 1 score: 63.3 bits; conditional E-value: 8.4e-21 Rsm22 163 hivAPCPHeaaCPlvatedwChFsqrvaRlslhrlaksasvpvedekfsy..vakerqprasaaaRvvrptkvrskkvlidlCsede 247 + APCPHe+ CP +++ C Fsq ++ k +ekfs +a+++ ++a+ ++R+ +p +r ++v ++lC d+ tr|H0YJW1|H0YJW1_HUMAN 4 FVFAPCPHELPCPQLTN-LACSFSQAYHPIPFSWNKKP-----KEEKFSMviLARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDG 84 588**********9999.89*******98887776664.....689****6455555556666************************ PP Rsm22 248 tlqrlvvtK.rkGeay 262 ++q+ v+t r+G+ + tr|H0YJW1|H0YJW1_HUMAN 85 HMQHAVLTArRHGSSW 100 ********989*9864 PP >> tr|G3V3X6|G3V3X6_HUMAN Methyltransferase-like protein 17, mitochondrial (Fragment) OS=Homo sapiens GN=METTL17 PE=2 S # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 54.3 0.0 4.6e-18 5.9e-14 4 69 .. 73 139 .. 70 140 .] 0.97 Alignments for each domain: == domain 1 score: 54.3 bits; conditional E-value: 4.6e-18 Rsm22 4 siaYalarlpatyavlrrvLdelaervpdflPkslldvgegpgtalwaaselwe.eleevlvidase 69 s++Y++arl + +a++ r+ +e+++r p f+P++l+d+g+g+g ++waa+ +w +l+e++ +d+s+ tr|G3V3X6|G3V3X6_HUMAN 73 SLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGqSLREYMCVDRSA 139 789***************************************************99*********97 PP >> tr|G3V4P2|G3V4P2_HUMAN Methyltransferase-like protein 17, mitochondrial (Fragment) OS=Homo sapiens GN=METTL17 PE=2 S # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.4 0.0 5.7e-05 0.72 4 33 .. 73 102 .] 70 102 .] 0.95 Alignments for each domain: == domain 1 score: 11.4 bits; conditional E-value: 5.7e-05 Rsm22 4 siaYalarlpatyavlrrvLdelaervpdf 33 s++Y++arl + +a++ r+ +e+++r p f tr|G3V4P2|G3V4P2_HUMAN 73 SLVYMAARLDGGFAAVSRAFHEIRARNPAF 102 789************************988 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (275 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 2122 (0.0239847); expected 1769.5 (0.02) Passed bias filter: 1615 (0.0182542); expected 1769.5 (0.02) Passed Vit filter: 118 (0.00133374); expected 88.5 (0.001) Passed Fwd filter: 7 (7.91202e-05); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 7 [number of targets reported over threshold] # CPU time: 0.71u 0.02s 00:00:00.73 Elapsed: 00:00:00.27 # Mc/sec: 35719.97 // [ok]