# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file:                  pfam_list/SpoU_methylase.hmm.txt
# target sequence database:        proteomes/Thermococcus_kodakarensis.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query:       SpoU_methylase  [M=142]
Accession:   PF00588.18
Description: SpoU rRNA Methylase family
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence               Description
    ------- ------ -----    ------- ------ -----   ---- --  --------               -----------
    5.2e-35  117.8   0.0    7.8e-35  117.2   0.0    1.3  1  tr|Q5JGC0|Q5JGC0_THEKO  Probable tRNA/rRNA methyltransferase,
    4.8e-07   27.1   0.0     0.0016   15.7   0.0    2.2  2  tr|Q5JDI9|Q5JDI9_THEKO  Uncharacterized protein OS=Thermococc
    0.00084   16.6   0.0     0.0011   16.2   0.0    1.2  1  sp|Q5JEG5|TRM56_THEKO   tRNA (cytidine(56)-2'-O)-methyltransf


Domain annotation for each sequence (and alignments):
>> tr|Q5JGC0|Q5JGC0_THEKO  Probable tRNA/rRNA methyltransferase, SpoU family OS=Thermococcus kodakarensis (strain ATCC B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  117.2   0.0     1e-37   7.8e-35       2     142 .]       2     150 ..       1     150 [. 0.91

  Alignments for each domain:
  == domain 1  score: 117.2 bits;  conditional E-value: 1e-37
                             EEEEEES-SSHHHHHHHHHHHHHTT-SEEEEESGSSCTCGSHHHHHHCTTHHHHHH.EEEESSHHHHHHHHCCCTEEEEEEST.T-S CS
          SpoU_methylase   2 livvlveiedpgNlGaiaRtakafgaselvlvkprsadllnpeakraaagalevle.lkvvdsleealkelkeegfalvatsl.kgk 86 
                             + vvlve+e p N+G+iaRt+k+fg+s+lvl++p+     ++e ++ a++a++vle + + ds+e+al+ ++ +    v+t++  gk
  tr|Q5JGC0|Q5JGC0_THEKO   2 ISVVLVEPEGPANIGMIARTMKNFGFSRLVLINPNL----TEESYAYAVHARDVLEnALILDSFEKALELFDFT----VGTTGkPGK 80 
                             78*******************************776....699*****************************99....888887777 PP

                             EGCCS..............HHHTTEEEEEEBTTTBS-HHHHCTSSEEEE----TTSSS--HHHHHHHHHH CS
          SpoU_methylase  87 slsei..............dlkekvalvfGnEdkGlsnelleladrlvkIpmsgeveSLNvavAvailly 142
                             ++ +               d++++v ++fG+E+ Gl+ne+l+++d +++Ip+s+e++ +N+a+A+a++ly
  tr|Q5JGC0|Q5JGC0_THEKO  81 RFIPHraplmpwelvglikDYPGEVGIFFGRESIGLKNEELDAMDVTLTIPTSEEYPVMNLAQAAAVVLY 150
                             6663333556667788888888**********************************************99 PP

>> tr|Q5JDI9|Q5JDI9_THEKO  Uncharacterized protein OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0   0.00018      0.14      15      42 ..      25      49 ..      19      77 .. 0.80
   2 !   15.7   0.0   2.1e-06    0.0016      59     110 ..     158     213 ..     113     232 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00018
                            HHHHHHHHHHTT-SEEEEESGSSCTCGS CS
          SpoU_methylase 15 lGaiaRtakafgaselvlvkprsadlln 42
                            +G +aR++++fg++++++ +  +    +
  tr|Q5JDI9|Q5JDI9_THEKO 25 VGQVARACSIFGVEHIWIYRAGGR---D 49
                            8**************999775444...4 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 2.1e-06
                             EEESSHHHHHHHHCCCTEEE.EEESTT-SEGCCSHHH...TTEEEEEEBTTTBS-H CS
          SpoU_methylase  59 kvvdsleealkelkeegfal.vatslkgkslseidlk...ekvalvfGnEdkGlsn 110
                             +v+ + +++ k lk++g++l +ats+kg++++e++++   ++v +vfG+ +kG+ +
  tr|Q5JDI9|Q5JDI9_THEKO 158 RVHLTRKSLAKTLKKAGLDLvIATSRKGRDIREVEIPpleGEVGFVFGSPRKGVME 213
                             56666677778888899777477777******99777777***********99976 PP

>> sp|Q5JEG5|TRM56_THEKO  tRNA (cytidine(56)-2'-O)-methyltransferase OS=Thermococcus kodakarensis (strain ATCC BAA-918 /
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   1.5e-06    0.0011      18     122 ..      24     132 ..      18     145 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 1.5e-06
                            HHHHHHHTT-SEEEEESGSSCTCGSHHHHHHCTTHHHHHHEEEESSHHHHHHHHCCCTEEEEEESTT-SEGCCS......HHH..TTE CS
         SpoU_methylase  18 iaRtakafgaselvlvkprsadllnpeakraaagalevlelkvvdsleealkelkeegfalvatslkgkslsei......dlk..ekv 97 
                            +a ta+afga+++++ +++ +   ++ +  +       +e++  +s++++l+e+k++g+ +  ++ +g +++++      +lk  +  
  sp|Q5JEG5|TRM56_THEKO  24 VALTARAFGADKIIIAAEEDE-HVKESVEDVVNRWGGPFEIEFNPSWKKILREWKDRGIIV-HLTMYGIHIDDAiprikdELKsgKDL 109
                            56699**********996665.888889999888888889999**************6555.44466776665445444433366*** PP

                            EEEEEBTTTBS-HHHHCTSSEEEE- CS
         SpoU_methylase  98 alvfGnEdkGlsnelleladrlvkI 122
                            ++v+G E+  +++e+ e ad+ v +
  sp|Q5JEG5|TRM56_THEKO 110 LIVVGAEK--VPREVYEMADYNVAV 132
                            *******7..788888888887766 PP



Internal pipeline statistics summary:
-------------------------------------
Query model(s):                              1  (142 nodes)
Target sequences:                         2301  (637680 residues searched)
Passed MSV filter:                        77  (0.0334637); expected 46.0 (0.02)
Passed bias filter:                       74  (0.0321599); expected 46.0 (0.02)
Passed Vit filter:                        13  (0.00564972); expected 2.3 (0.001)
Passed Fwd filter:                         3  (0.00130378); expected 0.0 (1e-05)
Initial search space (Z):               2301  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.02u 0.00s 00:00:00.02 Elapsed: 00:00:00.01
# Mc/sec: 9055.06
//
[ok]