# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/TRM.hmm.txt
# target sequence database: proteomes/Homo_sapiens.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: TRM [M=376]
Accession: PF02005.15
Description: N2,N2-dimethylguanosine tRNA methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
2.1e-151 506.6 0.0 2.5e-151 506.4 0.0 1.0 1 sp|Q9NXH9|TRM1_HUMAN tRNA (guanine(26)-N(2))-dimethyltran
5.8e-142 475.6 0.0 1e-141 474.8 0.0 1.4 1 sp|Q9NXH9-2|TRM1_HUMAN Isoform 2 of tRNA (guanine(26)-N(2))
3.9e-74 252.4 0.2 4.2e-74 252.2 0.2 1.0 1 tr|K7EJX9|K7EJX9_HUMAN tRNA (guanine(26)-N(2))-dimethyltran
1.4e-68 234.1 0.4 1.6e-52 181.2 0.0 2.0 2 tr|K7EQQ8|K7EQQ8_HUMAN tRNA (guanine(26)-N(2))-dimethyltran
1e-65 224.6 3.2 2.7e-55 190.4 0.5 3.1 3 sp|Q7Z2T5|TRM1L_HUMAN TRMT1-like protein OS=Homo sapiens G
1.3e-51 178.2 5.1 1.5e-51 178.0 2.0 2.3 2 sp|Q7Z2T5-2|TRM1L_HUMAN Isoform 2 of TRMT1-like protein OS=H
1.2e-08 36.8 0.0 1.4e-08 36.7 0.0 1.1 1 tr|K7EQU7|K7EQU7_HUMAN tRNA (guanine(26)-N(2))-dimethyltran
1.7e-07 33.0 0.0 1.9e-07 32.9 0.0 1.0 1 tr|K7ENI9|K7ENI9_HUMAN tRNA (guanine(26)-N(2))-dimethyltran
3.2e-06 28.9 0.0 3.4e-06 28.8 0.0 1.0 1 tr|K7EQY6|K7EQY6_HUMAN tRNA (guanine(26)-N(2))-dimethyltran
------ inclusion threshold ------
0.37 12.2 0.0 0.59 11.5 0.0 1.3 1 sp|Q32P41|TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransfer
0.57 11.6 0.0 0.69 11.3 0.0 1.1 1 tr|M0R2Z8|M0R2Z8_HUMAN Serine/threonine-protein kinase D2 (
Domain annotation for each sequence (and alignments):
>> sp|Q9NXH9|TRM1_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 506.4 0.0 3.1e-155 2.5e-151 12 376 .] 57 500 .. 45 500 .. 0.94
Alignments for each domain:
== domain 1 score: 506.4 bits; conditional E-value: 3.1e-155
SS.......--TT--SS--GGGHHHHHHHHHH........HHHHHHHH-S-...................................... CS
TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvi....r.qlellkkklgek...................................... 50
vt +++++eVFYNPvqefnRDl+++vi r ql +++ +++ +
sp|Q9NXH9|TRM1_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTCAVItefaRiQLGAKGIQIKVPgekdtqkvvvdlseqeeekvelkesenlasgdqprtaa 145
224455556***********************977766666777777766699************************************ PP
........EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC...--SS-EEEEEE-- CS
TRM 51 ........ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla...ekkkrfdviDlDP 128
++vl++L+asGlR+iRfalEvpg ++v+aND+s++Av+li++Nv+ln+v+++v+++++dA++l++ ++++rfdviDlDP
sp|Q9NXH9|TRM1_HUMAN 146 vgeiceegLHVLEGLAASGLRSIRFALEVPGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhqRVSERFDVIDLDP 234
*************************************************************************8877889********* PP
SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEE CS
TRM 129 fGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvr 217
+Gspa+fld+avq+v+e+glL+vT+TD+avLaG+s e+c++kYga+alks++cHE+alRi+l++++ +a++Y+++v+plls+sadfYvr
sp|Q9NXH9|TRM1_HUMAN 235 YGSPATFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDLRANCYQRFVVPLLSISADFYVR 323
***************************************************************************************** PP
EEEEEEE-HHHHHHHHTTEEEEEEETTT.........--EEEE--GGG--........SB-TTT-SBEEEEEEEE-S-S--HHHHHHHH CS
TRM 218 vfvkvktgaakvkkvleklglvlhCsgC.........lseekvkglakfk........aecehcgaklhlaGPlwlgplkdkefveevl 289
vfv+v tg+akvk++++k++lv++C+gC +++ +g+akf+ ecehcg++++l+GP+w++p++d +fv++vl
sp|Q9NXH9|TRM1_HUMAN 324 VFVRVFTGQAKVKASASKQALVFQCVGCgafhlqrlgKASGVPSGRAKFSaacgppvtPECEHCGQRHQLGGPMWAEPIHDLDFVGRVL 412
*******************************9988764448999999999*************************************** PP
HHHCT..-TTS..-HHHHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHHHH CS
TRM 290 eeaekekeeel..kkrvkklLklikeElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvevlr 376
e+++++ ++ ++r++++L++i+eEl+d+plyy+l+ql+s++++++p+l +++sal++++f+vs++Ha+++a+kT+ap++a+++++r
sp|Q9NXH9|TRM1_HUMAN 413 EAVSANP-GRFhtSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMR 500
*****75.44445***************************************************************************7 PP
>> sp|Q9NXH9-2|TRM1_HUMAN Isoform 2 of tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 474.8 0.0 1.3e-145 1e-141 12 376 .] 57 471 .. 45 471 .. 0.93
Alignments for each domain:
== domain 1 score: 474.8 bits; conditional E-value: 1.3e-145
SS.......--TT--SS--GGGHHHHHHHHHH........HHHHHHHH-S-.................................... CS
TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvi....r.qlellkkklgek.................................... 50
vt +++++eVFYNPvqefnRDl+++vi r ql +++ +++ +
sp|Q9NXH9-2|TRM1_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTCAVItefaRiQLGAKGIQIKVPgekdtqkvvvdlseqeeekvelkesenlasgdqprt 143
224455556***********************977766666777777766699********************************** PP
..........EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC...--SS-EEEE CS
TRM 51 ..........ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla...ekkkrfdvi 124
++vl++L+asGlR+iRfalEvpg ++v+aND+s++Av+li++Nv+ln+v+++v+++++dA++l++ ++++rfdvi
sp|Q9NXH9-2|TRM1_HUMAN 144 aavgeiceegLHVLEGLAASGLRSIRFALEVPGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhqRVSERFDVI 230
***************************************************************************8877889***** PP
EE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEE CS
TRM 125 DlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalkselcHEvalRillkavareaakYekavepllsls 211
DlDP+Gspa+fld+avq+v+e+glL+vT+TD+avLaG+s e+c++kYga+alks++cHE+alRi+l++++ +a++Y+++v+plls+s
sp|Q9NXH9-2|TRM1_HUMAN 231 DLDPYGSPATFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDLRANCYQRFVVPLLSIS 317
*************************************************************************************** PP
ETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT--EEEE--GGG--SB-TTT-SBEEEEEEEE-S-S--HHHHHHHHHHHCT..-T CS
TRM 212 adfYvrvfvkvktgaakvkkvleklglvlhCsgClseekvkglakfkaecehcgaklhlaGPlwlgplkdkefveevleeaekekee 298
adfYvrvfv+v tg+akvk++++ + C + ecehcg++++l+GP+w++p++d +fv++vle+++++
sp|Q9NXH9-2|TRM1_HUMAN 318 ADFYVRVFVRVFTGQAKVKASARAKF-SAA---CG--------PPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANP-G 391
*******************9987643.334...33........344579**********************************75.4 PP
TS..-HHHHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHHHH CS
TRM 299 el..kkrvkklLklikeElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvevlr 376
++ ++r++++L++i+eEl+d+plyy+l+ql+s++++++p+l +++sal++++f+vs++Ha+++a+kT+ap++a+++++r
sp|Q9NXH9-2|TRM1_HUMAN 392 RFhtSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMR 471
4445***************************************************************************7 PP
>> tr|K7EJX9|K7EJX9_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase (Fragment) OS=Homo sapiens GN=TRMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 252.2 0.2 5.3e-78 4.2e-74 112 281 .. 1 190 [. 1 191 [] 0.96
Alignments for each domain:
== domain 1 score: 252.2 bits; conditional E-value: 5.3e-78
HHHC...--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHH CS
TRM 112 vlla...ekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalkselcHEvalRillkavar 195
+l++ ++++rfdviDlDP+Gspa+fld+avq+v+e+glL+vT+TD+avLaG+s e+c++kYga+alks++cHE+alRi+l++++
tr|K7EJX9|K7EJX9_HUMAN 1 MLMYqhqRVSERFDVIDLDPYGSPATFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDL 87
56776667889**************************************************************************** PP
HHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT.........--EEEE--GGG--........SB-TTT- CS
TRM 196 eaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsgC.........lseekvkglakfk........aecehcg 265
+a++Y+++v+plls+sadfYvrvfv+v tg+akvk++++k++lv++C+gC +++ +g+akf+ ecehcg
tr|K7EJX9|K7EJX9_HUMAN 88 RANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCgafhlqrlgKASGVPSGRAKFSaacgppvtPECEHCG 174
*****************************************************9988764448999999999*************** PP
SBEEEEEEEE-S-S-- CS
TRM 266 aklhlaGPlwlgplkd 281
++++l+GP+w++p++d
tr|K7EJX9|K7EJX9_HUMAN 175 QRHQLGGPMWAEPIHD 190
***************8 PP
>> tr|K7EQQ8|K7EQQ8_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase (Fragment) OS=Homo sapiens GN=TRMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 181.2 0.0 2e-56 1.6e-52 12 142 .. 57 248 .. 45 249 .. 0.90
2 ! 52.7 0.3 2.3e-17 1.9e-13 184 232 .. 248 296 .. 247 297 .] 0.96
Alignments for each domain:
== domain 1 score: 181.2 bits; conditional E-value: 2e-56
SS.......--TT--SS--GGGHHHHHHHHHH........HHHHHHHH-S-.................................... CS
TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvi....r.qlellkkklgek.................................... 50
vt +++++eVFYNPvqefnRDl+++vi r ql +++ +++ +
tr|K7EQQ8|K7EQQ8_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTCAVItefaRiQLGAKGIQIKVPgekdtqkvvvdlseqeeekvelkesenlasgdqprt 143
224555556***********************977766666777777766699********************************** PP
..........EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC...--SS-EEEE CS
TRM 51 ..........ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla...ekkkrfdvi 124
++vl++L+asGlR+iRfalEvpg ++v+aND+s++Av+li++Nv+ln+v+++v+++++dA++l++ ++++rfdvi
tr|K7EQQ8|K7EQQ8_HUMAN 144 aavgeiceegLHVLEGLAASGLRSIRFALEVPGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhqRVSERFDVI 230
***************************************************************************8877889***** PP
EE--SS--GGGHHHHHHH CS
TRM 125 DlDPfGspapfldsavqs 142
DlDP+Gspa+fld+avq+
tr|K7EQQ8|K7EQQ8_HUMAN 231 DLDPYGSPATFLDAAVQA 248
****************98 PP
== domain 2 score: 52.7 bits; conditional E-value: 2.3e-17
HHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHH CS
TRM 184 valRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkv 232
alRi+l++++ +a++Y+++v+plls+sadfYvrvfv+v tg+akvk++
tr|K7EQQ8|K7EQQ8_HUMAN 248 AALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKAS 296
59********************************************986 PP
>> sp|Q7Z2T5|TRM1L_HUMAN TRMT1-like protein OS=Homo sapiens GN=TRMT1L PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -1.3 0.1 0.59 4.7e+03 230 246 .. 174 200 .. 168 223 .. 0.65
2 ! 190.4 0.5 3.3e-59 2.7e-55 12 294 .. 242 550 .. 226 589 .. 0.83
3 ! 32.9 0.0 2.4e-11 1.9e-07 313 374 .. 629 687 .. 589 689 .. 0.79
Alignments for each domain:
== domain 1 score: -1.3 bits; conditional E-value: 0.59
HHHHTTEEEEEEETTT..........- CS
TRM 230 kkvleklglvlhCsgC..........l 246
+++++k+g +hC+ C l
sp|Q7Z2T5|TRM1L_HUMAN 174 EQITSKMGAHYHCIICsatitrrtdmL 200
78899***********66543333320 PP
== domain 2 score: 190.4 bits; conditional E-value: 3.3e-59
SS--TT--SS--GGGHHHHHHHHHH...HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT- CS
TRM 12 vtvskkeeVFYNPvqefnRDlsvlvirqlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklnev 99
+++k++ ++NP ++ nR l + l++l ++ ++++ lda+ a+G+ ++ +a+ + ++ +v +ND++e+ v li+eN +ln+
sp|Q7Z2T5|TRM1L_HUMAN 242 YSIPQKTDSYFNPKMKLNRQLIFCT---LAALAEE-RKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNKL 325
3499999**************9888...5666655.589*******************************************999998 PP
-......................GGEEEE-S-HHHHHC--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHH CS
TRM 100 e......................eivvineddAnvllaekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspe 165
+ +++ ++dAnvl+ + + fd+i lDPfG+++++ldsa + +++ g+++vT+TD ++L ++++
sp|Q7Z2T5|TRM1L_HUMAN 326 KvvvdskekeksddileegeknlGNIKVTKMDANVLM--HLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQH 411
888999999999*999999987636999999******..7899********************************************* PP
HHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT........ CS
TRM 166 kclrkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsgC........ 245
r+Yg + +++e++ E a Ri++ avar+aa+ +k +e+l++++ +++v v v+v +g++ ++++++k+ +++hC C
sp|Q7Z2T5|TRM1L_HUMAN 412 VARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCeerifqkd 499
********************************************************************************66654332 PP
..--EEEE--GGG--........SB-TTT-SBEEEEEEEE-S-S--HHHHHHHHHHHCT CS
TRM 246 ..lseekvkglakfk........aecehcgaklhlaGPlwlgplkdkefveevleeaek 294
+ + + + + g++ GPlw l ++ f++++l e +
sp|Q7Z2T5|TRM1L_HUMAN 500 gnM-----VEE---NpyrqlpcnCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLH 550
222.....222...1333444213334456666778****************9976555 PP
== domain 3 score: 32.9 bits; conditional E-value: 2.4e-11
HHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHH CS
TRM 313 eElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvev 374
+ p+yy++++ s+ +++p+lkk+ l ++gf+vsrtH+ p +++T+apl ++ +
sp|Q7Z2T5|TRM1L_HUMAN 629 T--EHPPFYYNIHR-HSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSI 687
2..36788888887.56889***********************************9888766 PP
>> sp|Q7Z2T5-2|TRM1L_HUMAN Isoform 2 of TRMT1-like protein OS=Homo sapiens GN=TRMT1L
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -0.2 0.1 0.26 2.1e+03 230 246 .. 18 44 .. 12 68 .. 0.65
2 ! 178.0 2.0 1.9e-55 1.5e-51 13 248 .. 83 338 .. 63 373 .. 0.90
Alignments for each domain:
== domain 1 score: -0.2 bits; conditional E-value: 0.26
HHHHTTEEEEEEETTT..........- CS
TRM 230 kkvleklglvlhCsgC..........l 246
+++++k+g +hC+ C l
sp|Q7Z2T5-2|TRM1L_HUMAN 18 EQITSKMGAHYHCIICsatitrrtdmL 44
78899***********66543333330 PP
== domain 2 score: 178.0 bits; conditional E-value: 1.9e-55
S....--TT--SS--GGGHHHHHHHHHH...HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHH CS
TRM 13 t....vskkeeVFYNPvqefnRDlsvlvirqlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNv 94
+++k++ ++NP ++ nR l + l++l ++ ++++ lda+ a+G+ ++ +a+ + ++ +v +ND++e+ v li+eN
sp|Q7Z2T5-2|TRM1L_HUMAN 83 CpnysIPQKTDSYFNPKMKLNRQLIFCT---LAALAEE-RKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENC 164
144449999***************9888...5666655.589*******************************************9 PP
HHTT--......................GGEEEE-S-HHHHHC--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHH CS
TRM 95 klneve......................eivvineddAnvllaekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtav 158
+ln+ + +++ ++dAnvl+ + + fd+i lDPfG+++++ldsa + +++ g+++vT+TD ++
sp|Q7Z2T5-2|TRM1L_HUMAN 165 HLNKLKvvvdskekeksddileegeknlGNIKVTKMDANVLM--HLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISS 248
99998888999999999*999999987636999999******..7899************************************** PP
HTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETT CS
TRM 159 LaGaspekclrkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsg 244
L ++++ r+Yg + +++e++ E a Ri++ avar+aa+ +k +e+l++++ +++v v v+v +g++ ++++++k+ +++hC
sp|Q7Z2T5-2|TRM1L_HUMAN 249 LYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQW 334
************************************************************************************** PP
T--E CS
TRM 245 Clse 248
C ++
sp|Q7Z2T5-2|TRM1L_HUMAN 335 CEER 338
*654 PP
>> tr|K7EQU7|K7EQU7_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase (Fragment) OS=Homo sapiens GN=TRMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 36.7 0.0 1.7e-12 1.4e-08 12 40 .. 57 93 .. 45 116 .. 0.74
Alignments for each domain:
== domain 1 score: 36.7 bits; conditional E-value: 1.7e-12
SS.......--TT--SS--GGGHHHHHHHHHH....H CS
TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvir.ql 40
vt +++++eVFYNPvqefnRDl+++vi +
tr|K7EQU7|K7EQU7_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTCAVITeFA 93
335555556***********************96333 PP
>> tr|K7ENI9|K7ENI9_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 32.9 0.0 2.4e-11 1.9e-07 12 41 .. 57 93 .. 45 101 .. 0.72
Alignments for each domain:
== domain 1 score: 32.9 bits; conditional E-value: 2.4e-11
SS.......--TT--SS--GGGHHHHHHHHHH...HH CS
TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvirqle 41
vt +++++eVFYNPvqefnRDl+ +++ + +
tr|K7ENI9|K7ENI9_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTKACMCWKA 93
335555556********************99975654 PP
>> tr|K7EQY6|K7EQY6_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 28.8 0.0 4.2e-10 3.4e-06 12 33 .. 57 85 .] 45 85 .] 0.72
Alignments for each domain:
== domain 1 score: 28.8 bits; conditional E-value: 4.2e-10
SS.......--TT--SS--GGGHHHHHHH CS
TRM 12 vt.......vskkeeVFYNPvqefnRDls 33
vt +++++eVFYNPvqefnRDl+
tr|K7EQY6|K7EQY6_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLT 85
335555556******************96 PP
>> sp|Q32P41|TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens GN=TRMT5 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.5 0.0 7.3e-05 0.59 55 115 .. 304 361 .. 241 370 .. 0.80
Alignments for each domain:
== domain 1 score: 11.5 bits; conditional E-value: 7.3e-05
ESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC CS
TRM 55 daLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla 115
d +++ G ai a+ +v+aND++++ + + N kln+v++ v++ + d + +l+
sp|Q32P41|TRM5_HUMAN 304 DVFAGVGPFAIPVAKK---NCTVFANDLNPESHKWLLYNCKLNKVDQKVKVFNLDGKDFLQ 361
5556666666666555...568************************988887778887775 PP
>> tr|M0R2Z8|M0R2Z8_HUMAN Serine/threonine-protein kinase D2 (Fragment) OS=Homo sapiens GN=PRKD2 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.3 0.0 8.6e-05 0.69 26 90 .. 46 113 .. 26 124 .. 0.86
Alignments for each domain:
== domain 1 score: 11.3 bits; conditional E-value: 8.6e-05
GHHHHHHHHHH......HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHH CS
TRM 26 qefnRDlsvlvi...rqlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAveli 90
++ RD++v vi r+ ++++l +++ +l++L G+ + E+p++ v++ + +e+i
tr|M0R2Z8|M0R2Z8_HUMAN 46 RKTGRDVAVKVIdklRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMI 113
5789********76567778888999****************************99998877777766 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (376 nodes)
Target sequences: 88473 (35070517 residues searched)
Passed MSV filter: 2455 (0.0277486); expected 1769.5 (0.02)
Passed bias filter: 1758 (0.0198705); expected 1769.5 (0.02)
Passed Vit filter: 125 (0.00141286); expected 88.5 (0.001)
Passed Fwd filter: 11 (0.000124332); expected 0.9 (1e-05)
Initial search space (Z): 88473 [actual number of targets]
Domain search space (domZ): 11 [number of targets reported over threshold]
# CPU time: 0.89u 0.03s 00:00:00.92 Elapsed: 00:00:00.28
# Mc/sec: 47094.69
//
[ok]