# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/TRM.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRM [M=376] Accession: PF02005.15 Description: N2,N2-dimethylguanosine tRNA methyltransferase Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 2.1e-151 506.6 0.0 2.5e-151 506.4 0.0 1.0 1 sp|Q9NXH9|TRM1_HUMAN tRNA (guanine(26)-N(2))-dimethyltran 5.8e-142 475.6 0.0 1e-141 474.8 0.0 1.4 1 sp|Q9NXH9-2|TRM1_HUMAN Isoform 2 of tRNA (guanine(26)-N(2)) 3.9e-74 252.4 0.2 4.2e-74 252.2 0.2 1.0 1 tr|K7EJX9|K7EJX9_HUMAN tRNA (guanine(26)-N(2))-dimethyltran 1.4e-68 234.1 0.4 1.6e-52 181.2 0.0 2.0 2 tr|K7EQQ8|K7EQQ8_HUMAN tRNA (guanine(26)-N(2))-dimethyltran 1e-65 224.6 3.2 2.7e-55 190.4 0.5 3.1 3 sp|Q7Z2T5|TRM1L_HUMAN TRMT1-like protein OS=Homo sapiens G 1.3e-51 178.2 5.1 1.5e-51 178.0 2.0 2.3 2 sp|Q7Z2T5-2|TRM1L_HUMAN Isoform 2 of TRMT1-like protein OS=H 1.2e-08 36.8 0.0 1.4e-08 36.7 0.0 1.1 1 tr|K7EQU7|K7EQU7_HUMAN tRNA (guanine(26)-N(2))-dimethyltran 1.7e-07 33.0 0.0 1.9e-07 32.9 0.0 1.0 1 tr|K7ENI9|K7ENI9_HUMAN tRNA (guanine(26)-N(2))-dimethyltran 3.2e-06 28.9 0.0 3.4e-06 28.8 0.0 1.0 1 tr|K7EQY6|K7EQY6_HUMAN tRNA (guanine(26)-N(2))-dimethyltran ------ inclusion threshold ------ 0.37 12.2 0.0 0.59 11.5 0.0 1.3 1 sp|Q32P41|TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransfer 0.57 11.6 0.0 0.69 11.3 0.0 1.1 1 tr|M0R2Z8|M0R2Z8_HUMAN Serine/threonine-protein kinase D2 ( Domain annotation for each sequence (and alignments): >> sp|Q9NXH9|TRM1_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 506.4 0.0 3.1e-155 2.5e-151 12 376 .] 57 500 .. 45 500 .. 0.94 Alignments for each domain: == domain 1 score: 506.4 bits; conditional E-value: 3.1e-155 SS.......--TT--SS--GGGHHHHHHHHHH........HHHHHHHH-S-...................................... CS TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvi....r.qlellkkklgek...................................... 50 vt +++++eVFYNPvqefnRDl+++vi r ql +++ +++ + sp|Q9NXH9|TRM1_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTCAVItefaRiQLGAKGIQIKVPgekdtqkvvvdlseqeeekvelkesenlasgdqprtaa 145 224455556***********************977766666777777766699************************************ PP ........EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC...--SS-EEEEEE-- CS TRM 51 ........ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla...ekkkrfdviDlDP 128 ++vl++L+asGlR+iRfalEvpg ++v+aND+s++Av+li++Nv+ln+v+++v+++++dA++l++ ++++rfdviDlDP sp|Q9NXH9|TRM1_HUMAN 146 vgeiceegLHVLEGLAASGLRSIRFALEVPGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhqRVSERFDVIDLDP 234 *************************************************************************8877889********* PP SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEE CS TRM 129 fGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvr 217 +Gspa+fld+avq+v+e+glL+vT+TD+avLaG+s e+c++kYga+alks++cHE+alRi+l++++ +a++Y+++v+plls+sadfYvr sp|Q9NXH9|TRM1_HUMAN 235 YGSPATFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDLRANCYQRFVVPLLSISADFYVR 323 ***************************************************************************************** PP EEEEEEE-HHHHHHHHTTEEEEEEETTT.........--EEEE--GGG--........SB-TTT-SBEEEEEEEE-S-S--HHHHHHHH CS TRM 218 vfvkvktgaakvkkvleklglvlhCsgC.........lseekvkglakfk........aecehcgaklhlaGPlwlgplkdkefveevl 289 vfv+v tg+akvk++++k++lv++C+gC +++ +g+akf+ ecehcg++++l+GP+w++p++d +fv++vl sp|Q9NXH9|TRM1_HUMAN 324 VFVRVFTGQAKVKASASKQALVFQCVGCgafhlqrlgKASGVPSGRAKFSaacgppvtPECEHCGQRHQLGGPMWAEPIHDLDFVGRVL 412 *******************************9988764448999999999*************************************** PP HHHCT..-TTS..-HHHHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHHHH CS TRM 290 eeaekekeeel..kkrvkklLklikeElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvevlr 376 e+++++ ++ ++r++++L++i+eEl+d+plyy+l+ql+s++++++p+l +++sal++++f+vs++Ha+++a+kT+ap++a+++++r sp|Q9NXH9|TRM1_HUMAN 413 EAVSANP-GRFhtSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMR 500 *****75.44445***************************************************************************7 PP >> sp|Q9NXH9-2|TRM1_HUMAN Isoform 2 of tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 474.8 0.0 1.3e-145 1e-141 12 376 .] 57 471 .. 45 471 .. 0.93 Alignments for each domain: == domain 1 score: 474.8 bits; conditional E-value: 1.3e-145 SS.......--TT--SS--GGGHHHHHHHHHH........HHHHHHHH-S-.................................... CS TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvi....r.qlellkkklgek.................................... 50 vt +++++eVFYNPvqefnRDl+++vi r ql +++ +++ + sp|Q9NXH9-2|TRM1_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTCAVItefaRiQLGAKGIQIKVPgekdtqkvvvdlseqeeekvelkesenlasgdqprt 143 224455556***********************977766666777777766699********************************** PP ..........EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC...--SS-EEEE CS TRM 51 ..........ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla...ekkkrfdvi 124 ++vl++L+asGlR+iRfalEvpg ++v+aND+s++Av+li++Nv+ln+v+++v+++++dA++l++ ++++rfdvi sp|Q9NXH9-2|TRM1_HUMAN 144 aavgeiceegLHVLEGLAASGLRSIRFALEVPGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhqRVSERFDVI 230 ***************************************************************************8877889***** PP EE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEE CS TRM 125 DlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalkselcHEvalRillkavareaakYekavepllsls 211 DlDP+Gspa+fld+avq+v+e+glL+vT+TD+avLaG+s e+c++kYga+alks++cHE+alRi+l++++ +a++Y+++v+plls+s sp|Q9NXH9-2|TRM1_HUMAN 231 DLDPYGSPATFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDLRANCYQRFVVPLLSIS 317 *************************************************************************************** PP ETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT--EEEE--GGG--SB-TTT-SBEEEEEEEE-S-S--HHHHHHHHHHHCT..-T CS TRM 212 adfYvrvfvkvktgaakvkkvleklglvlhCsgClseekvkglakfkaecehcgaklhlaGPlwlgplkdkefveevleeaekekee 298 adfYvrvfv+v tg+akvk++++ + C + ecehcg++++l+GP+w++p++d +fv++vle+++++ sp|Q9NXH9-2|TRM1_HUMAN 318 ADFYVRVFVRVFTGQAKVKASARAKF-SAA---CG--------PPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANP-G 391 *******************9987643.334...33........344579**********************************75.4 PP TS..-HHHHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHHHH CS TRM 299 el..kkrvkklLklikeElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvevlr 376 ++ ++r++++L++i+eEl+d+plyy+l+ql+s++++++p+l +++sal++++f+vs++Ha+++a+kT+ap++a+++++r sp|Q9NXH9-2|TRM1_HUMAN 392 RFhtSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMR 471 4445***************************************************************************7 PP >> tr|K7EJX9|K7EJX9_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase (Fragment) OS=Homo sapiens GN=TRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 252.2 0.2 5.3e-78 4.2e-74 112 281 .. 1 190 [. 1 191 [] 0.96 Alignments for each domain: == domain 1 score: 252.2 bits; conditional E-value: 5.3e-78 HHHC...--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHH CS TRM 112 vlla...ekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalkselcHEvalRillkavar 195 +l++ ++++rfdviDlDP+Gspa+fld+avq+v+e+glL+vT+TD+avLaG+s e+c++kYga+alks++cHE+alRi+l++++ tr|K7EJX9|K7EJX9_HUMAN 1 MLMYqhqRVSERFDVIDLDPYGSPATFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDL 87 56776667889**************************************************************************** PP HHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT.........--EEEE--GGG--........SB-TTT- CS TRM 196 eaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsgC.........lseekvkglakfk........aecehcg 265 +a++Y+++v+plls+sadfYvrvfv+v tg+akvk++++k++lv++C+gC +++ +g+akf+ ecehcg tr|K7EJX9|K7EJX9_HUMAN 88 RANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCgafhlqrlgKASGVPSGRAKFSaacgppvtPECEHCG 174 *****************************************************9988764448999999999*************** PP SBEEEEEEEE-S-S-- CS TRM 266 aklhlaGPlwlgplkd 281 ++++l+GP+w++p++d tr|K7EJX9|K7EJX9_HUMAN 175 QRHQLGGPMWAEPIHD 190 ***************8 PP >> tr|K7EQQ8|K7EQQ8_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase (Fragment) OS=Homo sapiens GN=TRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 181.2 0.0 2e-56 1.6e-52 12 142 .. 57 248 .. 45 249 .. 0.90 2 ! 52.7 0.3 2.3e-17 1.9e-13 184 232 .. 248 296 .. 247 297 .] 0.96 Alignments for each domain: == domain 1 score: 181.2 bits; conditional E-value: 2e-56 SS.......--TT--SS--GGGHHHHHHHHHH........HHHHHHHH-S-.................................... CS TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvi....r.qlellkkklgek.................................... 50 vt +++++eVFYNPvqefnRDl+++vi r ql +++ +++ + tr|K7EQQ8|K7EQQ8_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTCAVItefaRiQLGAKGIQIKVPgekdtqkvvvdlseqeeekvelkesenlasgdqprt 143 224555556***********************977766666777777766699********************************** PP ..........EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC...--SS-EEEE CS TRM 51 ..........ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla...ekkkrfdvi 124 ++vl++L+asGlR+iRfalEvpg ++v+aND+s++Av+li++Nv+ln+v+++v+++++dA++l++ ++++rfdvi tr|K7EQQ8|K7EQQ8_HUMAN 144 aavgeiceegLHVLEGLAASGLRSIRFALEVPGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhqRVSERFDVI 230 ***************************************************************************8877889***** PP EE--SS--GGGHHHHHHH CS TRM 125 DlDPfGspapfldsavqs 142 DlDP+Gspa+fld+avq+ tr|K7EQQ8|K7EQQ8_HUMAN 231 DLDPYGSPATFLDAAVQA 248 ****************98 PP == domain 2 score: 52.7 bits; conditional E-value: 2.3e-17 HHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHH CS TRM 184 valRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkv 232 alRi+l++++ +a++Y+++v+plls+sadfYvrvfv+v tg+akvk++ tr|K7EQQ8|K7EQQ8_HUMAN 248 AALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKAS 296 59********************************************986 PP >> sp|Q7Z2T5|TRM1L_HUMAN TRMT1-like protein OS=Homo sapiens GN=TRMT1L PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.3 0.1 0.59 4.7e+03 230 246 .. 174 200 .. 168 223 .. 0.65 2 ! 190.4 0.5 3.3e-59 2.7e-55 12 294 .. 242 550 .. 226 589 .. 0.83 3 ! 32.9 0.0 2.4e-11 1.9e-07 313 374 .. 629 687 .. 589 689 .. 0.79 Alignments for each domain: == domain 1 score: -1.3 bits; conditional E-value: 0.59 HHHHTTEEEEEEETTT..........- CS TRM 230 kkvleklglvlhCsgC..........l 246 +++++k+g +hC+ C l sp|Q7Z2T5|TRM1L_HUMAN 174 EQITSKMGAHYHCIICsatitrrtdmL 200 78899***********66543333320 PP == domain 2 score: 190.4 bits; conditional E-value: 3.3e-59 SS--TT--SS--GGGHHHHHHHHHH...HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT- CS TRM 12 vtvskkeeVFYNPvqefnRDlsvlvirqlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklnev 99 +++k++ ++NP ++ nR l + l++l ++ ++++ lda+ a+G+ ++ +a+ + ++ +v +ND++e+ v li+eN +ln+ sp|Q7Z2T5|TRM1L_HUMAN 242 YSIPQKTDSYFNPKMKLNRQLIFCT---LAALAEE-RKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNKL 325 3499999**************9888...5666655.589*******************************************999998 PP -......................GGEEEE-S-HHHHHC--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHH CS TRM 100 e......................eivvineddAnvllaekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspe 165 + +++ ++dAnvl+ + + fd+i lDPfG+++++ldsa + +++ g+++vT+TD ++L ++++ sp|Q7Z2T5|TRM1L_HUMAN 326 KvvvdskekeksddileegeknlGNIKVTKMDANVLM--HLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQH 411 888999999999*999999987636999999******..7899********************************************* PP HHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT........ CS TRM 166 kclrkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsgC........ 245 r+Yg + +++e++ E a Ri++ avar+aa+ +k +e+l++++ +++v v v+v +g++ ++++++k+ +++hC C sp|Q7Z2T5|TRM1L_HUMAN 412 VARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCeerifqkd 499 ********************************************************************************66654332 PP ..--EEEE--GGG--........SB-TTT-SBEEEEEEEE-S-S--HHHHHHHHHHHCT CS TRM 246 ..lseekvkglakfk........aecehcgaklhlaGPlwlgplkdkefveevleeaek 294 + + + + + g++ GPlw l ++ f++++l e + sp|Q7Z2T5|TRM1L_HUMAN 500 gnM-----VEE---NpyrqlpcnCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLH 550 222.....222...1333444213334456666778****************9976555 PP == domain 3 score: 32.9 bits; conditional E-value: 2.4e-11 HHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHH CS TRM 313 eElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvev 374 + p+yy++++ s+ +++p+lkk+ l ++gf+vsrtH+ p +++T+apl ++ + sp|Q7Z2T5|TRM1L_HUMAN 629 T--EHPPFYYNIHR-HSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSI 687 2..36788888887.56889***********************************9888766 PP >> sp|Q7Z2T5-2|TRM1L_HUMAN Isoform 2 of TRMT1-like protein OS=Homo sapiens GN=TRMT1L # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -0.2 0.1 0.26 2.1e+03 230 246 .. 18 44 .. 12 68 .. 0.65 2 ! 178.0 2.0 1.9e-55 1.5e-51 13 248 .. 83 338 .. 63 373 .. 0.90 Alignments for each domain: == domain 1 score: -0.2 bits; conditional E-value: 0.26 HHHHTTEEEEEEETTT..........- CS TRM 230 kkvleklglvlhCsgC..........l 246 +++++k+g +hC+ C l sp|Q7Z2T5-2|TRM1L_HUMAN 18 EQITSKMGAHYHCIICsatitrrtdmL 44 78899***********66543333330 PP == domain 2 score: 178.0 bits; conditional E-value: 1.9e-55 S....--TT--SS--GGGHHHHHHHHHH...HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHH CS TRM 13 t....vskkeeVFYNPvqefnRDlsvlvirqlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNv 94 +++k++ ++NP ++ nR l + l++l ++ ++++ lda+ a+G+ ++ +a+ + ++ +v +ND++e+ v li+eN sp|Q7Z2T5-2|TRM1L_HUMAN 83 CpnysIPQKTDSYFNPKMKLNRQLIFCT---LAALAEE-RKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENC 164 144449999***************9888...5666655.589*******************************************9 PP HHTT--......................GGEEEE-S-HHHHHC--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHH CS TRM 95 klneve......................eivvineddAnvllaekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtav 158 +ln+ + +++ ++dAnvl+ + + fd+i lDPfG+++++ldsa + +++ g+++vT+TD ++ sp|Q7Z2T5-2|TRM1L_HUMAN 165 HLNKLKvvvdskekeksddileegeknlGNIKVTKMDANVLM--HLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISS 248 99998888999999999*999999987636999999******..7899************************************** PP HTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETT CS TRM 159 LaGaspekclrkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsg 244 L ++++ r+Yg + +++e++ E a Ri++ avar+aa+ +k +e+l++++ +++v v v+v +g++ ++++++k+ +++hC sp|Q7Z2T5-2|TRM1L_HUMAN 249 LYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQW 334 ************************************************************************************** PP T--E CS TRM 245 Clse 248 C ++ sp|Q7Z2T5-2|TRM1L_HUMAN 335 CEER 338 *654 PP >> tr|K7EQU7|K7EQU7_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase (Fragment) OS=Homo sapiens GN=TRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 36.7 0.0 1.7e-12 1.4e-08 12 40 .. 57 93 .. 45 116 .. 0.74 Alignments for each domain: == domain 1 score: 36.7 bits; conditional E-value: 1.7e-12 SS.......--TT--SS--GGGHHHHHHHHHH....H CS TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvir.ql 40 vt +++++eVFYNPvqefnRDl+++vi + tr|K7EQU7|K7EQU7_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTCAVITeFA 93 335555556***********************96333 PP >> tr|K7ENI9|K7ENI9_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 32.9 0.0 2.4e-11 1.9e-07 12 41 .. 57 93 .. 45 101 .. 0.72 Alignments for each domain: == domain 1 score: 32.9 bits; conditional E-value: 2.4e-11 SS.......--TT--SS--GGGHHHHHHHHHH...HH CS TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvirqle 41 vt +++++eVFYNPvqefnRDl+ +++ + + tr|K7ENI9|K7ENI9_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLTKACMCWKA 93 335555556********************99975654 PP >> tr|K7EQY6|K7EQY6_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens GN=TRMT1 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 28.8 0.0 4.2e-10 3.4e-06 12 33 .. 57 85 .] 45 85 .] 0.72 Alignments for each domain: == domain 1 score: 28.8 bits; conditional E-value: 4.2e-10 SS.......--TT--SS--GGGHHHHHHH CS TRM 12 vt.......vskkeeVFYNPvqefnRDls 33 vt +++++eVFYNPvqefnRDl+ tr|K7EQY6|K7EQY6_HUMAN 57 VTegaakiaFPSANEVFYNPVQEFNRDLT 85 335555556******************96 PP >> sp|Q32P41|TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens GN=TRMT5 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.5 0.0 7.3e-05 0.59 55 115 .. 304 361 .. 241 370 .. 0.80 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 7.3e-05 ESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC CS TRM 55 daLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla 115 d +++ G ai a+ +v+aND++++ + + N kln+v++ v++ + d + +l+ sp|Q32P41|TRM5_HUMAN 304 DVFAGVGPFAIPVAKK---NCTVFANDLNPESHKWLLYNCKLNKVDQKVKVFNLDGKDFLQ 361 5556666666666555...568************************988887778887775 PP >> tr|M0R2Z8|M0R2Z8_HUMAN Serine/threonine-protein kinase D2 (Fragment) OS=Homo sapiens GN=PRKD2 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 11.3 0.0 8.6e-05 0.69 26 90 .. 46 113 .. 26 124 .. 0.86 Alignments for each domain: == domain 1 score: 11.3 bits; conditional E-value: 8.6e-05 GHHHHHHHHHH......HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHH CS TRM 26 qefnRDlsvlvi...rqlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAveli 90 ++ RD++v vi r+ ++++l +++ +l++L G+ + E+p++ v++ + +e+i tr|M0R2Z8|M0R2Z8_HUMAN 46 RKTGRDVAVKVIdklRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMI 113 5789********76567778888999****************************99998877777766 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (376 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 2455 (0.0277486); expected 1769.5 (0.02) Passed bias filter: 1758 (0.0198705); expected 1769.5 (0.02) Passed Vit filter: 125 (0.00141286); expected 88.5 (0.001) Passed Fwd filter: 11 (0.000124332); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 11 [number of targets reported over threshold] # CPU time: 0.89u 0.03s 00:00:00.92 Elapsed: 00:00:00.28 # Mc/sec: 47094.69 // [ok]