# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/TRM.hmm.txt
# target sequence database: proteomes/Macaca_mulatta.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: TRM [M=376]
Accession: PF02005.15
Description: N2,N2-dimethylguanosine tRNA methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
3.3e-144 480.9 0.0 4.2e-144 480.6 0.0 1.0 1 tr|F6RHQ5|F6RHQ5_MACMU tRNA (guanine(26)-N(2))-dimethyl
5.3e-66 223.6 2.9 1.6e-55 189.1 0.5 3.1 3 tr|F6RCB6|F6RCB6_MACMU TRMT1-like protein isoform 1 OS=
------ inclusion threshold ------
0.022 14.2 0.0 0.034 13.6 0.0 1.3 1 sp|F7GSQ4|TRM5_MACMU tRNA (guanine(37)-N1)-methyltran
0.023 14.1 0.0 0.035 13.5 0.0 1.2 1 tr|A0A1I7Q472|A0A1I7Q472_MACMU tRNA (guanine(37)-N1)-methyltran
Domain annotation for each sequence (and alignments):
>> tr|F6RHQ5|F6RHQ5_MACMU tRNA (guanine(26)-N(2))-dimethyltransferase OS=Macaca mulatta OX=9544 GN=TRMT1 PE=3 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 480.6 0.0 7.9e-148 4.2e-144 7 376 .] 53 488 .. 42 488 .. 0.91
Alignments for each domain:
== domain 1 score: 480.6 bits; conditional E-value: 7.9e-148
E----.SS--TT--SS--GGGHHHHHHHHHH........HHHHHHHH-S-..................................... CS
TRM 7 vedke.vtvskkeeVFYNPvqefnRDlsvlvi....r.qlellkkklgek..................................... 50
+e+++ + +++++eVFYNPvqefnRDl+++vi r ql +++ +++ +
tr|F6RHQ5|F6RHQ5_MACMU 53 TEGAAkIAFPSANEVFYNPVQEFNRDLTCAVItefaRiQLGAKGIQIKVPgekdtqkvvvdlseqeeekvelkenedlasgdqprta 139
33333266***********************977766666777777766699*********************************** PP
.........EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC...--SS-EEEEE CS
TRM 51 .........ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla...ekkkrfdviD 125
++vl++L+asGlR+iRfalEvpg ++v+aND s +Av+li++Nv+ln+v+++v+++++dA++l++ ++++rfdviD
tr|F6RHQ5|F6RHQ5_MACMU 140 avgeiceegLHVLEGLAASGLRSIRFALEVPGLRSVVANDTSARAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhqRVSERFDVID 226
**************************************************************************8877889****** PP
E--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEE CS
TRM 126 lDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalkselcHEvalRillkavareaakYekavepllslsa 212
lDP+Gspapfld+avq+v+e+glL+vT+TD+avLaG+s e+c++kYga+alks++cHE+alRi+l++++ +a++Y+++v+plls+sa
tr|F6RHQ5|F6RHQ5_MACMU 227 LDPYGSPAPFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDLRANCYQRFVVPLLSISA 313
*************************************************************************************** PP
TTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT.......--EEEE--GGG--.....SB-TTT-SBEEEEEEEE-S-S--HHHHHH CS
TRM 213 dfYvrvfvkvktgaakvkkvleklglvlhCsgC.......lseekvkglakfk.....aecehcgaklhlaGPlwlgplkdkefvee 287
dfYvrvfv+v tg+akvk++++k++lv++C+gC l +k +g+ + + +l+GP+w++p++d +fv++
tr|F6RHQ5|F6RHQ5_MACMU 314 DFYVRVFVRVFTGQAKVKASASKQALVFQCVGCgayhlqrL--GKASGVPGSRvsevmVPAHLSPVLPQLGGPVWAEPIHDLDFVGR 398
*********************************88775331..455555444444442333334456799***************** PP
HHHHHCT..-TTS..-HHHHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHH CS
TRM 288 vleeaekekeeel..kkrvkklLklikeElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavv 372
vle+++++ ++ ++r++++L++i+eEl+d+plyy+l+ql+s++++++p+l +++sal++++f+vs++Ha+++a+kT+ap++a++
tr|F6RHQ5|F6RHQ5_MACMU 399 VLEAVSANP-GRFhtSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALW 484
*******75.44445************************************************************************ PP
HHHH CS
TRM 373 evlr 376
+++r
tr|F6RHQ5|F6RHQ5_MACMU 485 DIMR 488
***7 PP
>> tr|F6RCB6|F6RCB6_MACMU TRMT1-like protein isoform 1 OS=Macaca mulatta OX=9544 GN=TRMT1L PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -1.9 0.0 0.32 1.7e+03 230 246 .. 176 201 .. 171 223 .. 0.64
2 ! 189.1 0.5 3e-59 1.6e-55 12 294 .. 244 552 .. 228 591 .. 0.84
3 ! 33.0 0.0 8.1e-12 4.3e-08 312 374 .. 630 689 .. 593 691 .. 0.78
Alignments for each domain:
== domain 1 score: -1.9 bits; conditional E-value: 0.32
HHHHTTEEEEEEETTT.........- CS
TRM 230 kkvleklglvlhCsgC.........l 246
+++ +k+g +hC+ C +
tr|F6RCB6|F6RCB6_MACMU 176 EQISSKMGAHYHCIICsatitrrtdM 201
678899**********6554333220 PP
== domain 2 score: 189.1 bits; conditional E-value: 3e-59
SS--TT--SS--GGGHHHHHHHHHH...HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT CS
TRM 12 vtvskkeeVFYNPvqefnRDlsvlvirqlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklne 98
+++k++ ++NP ++ nR l + l++l ++ ++++ lda+ a+G+ ++ +a+ + ++ +v +ND++e+ v li+eN ln+
tr|F6RCB6|F6RCB6_MACMU 244 YSIPQKTDSYFNPKMKLNRQLIFCT---LAALAEE-RKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCYLNK 326
3499999**************9888...5666655.589*******************************************88888 PP
--......................GGEEEE-S-HHHHHC--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSS CS
TRM 99 ve......................eivvineddAnvllaekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtavLaGas 163
+ +++ ++dAnvl+ + + fd+i lDPfG+++++ldsa + +++ g+++vT+TD ++L ++
tr|F6RCB6|F6RCB6_MACMU 327 LKvvvdskekeksddileegekniGNIKVTKMDANVLM--HLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKA 411
77778888888999999999886635899999******..7899******************************************* PP
HHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT..... CS
TRM 164 pekclrkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsgC..... 245
++ r+Yg + +++e++ E a Ri++ avar+aa+ +k +e+l++++ +++v v v+v +g++ ++++++k+ +++hC C
tr|F6RCB6|F6RCB6_MACMU 412 QHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCeerif 498
**********************************************************************************66654 PP
.....--EEEE--GGG--........SB-TTT-SBEEEEEEEE-S-S--HHHHHHHHHHHCT CS
TRM 246 .....lseekvkglakfk........aecehcgaklhlaGPlwlgplkdkefveevleeaek 294
+ + + + + g++ GPlw l ++ f++++l e +
tr|F6RCB6|F6RCB6_MACMU 499 qkdgnM-----VEE---NpyrqlpcnCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLH 552
332222.....222...1333444213334456666778****************9866544 PP
== domain 3 score: 33.0 bits; conditional E-value: 8.1e-12
HHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHH CS
TRM 312 keElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvev 374
+ E + p+yy++++ s+ +++p+lkk+ l ++gf+vsrtH+ p +++T+apl ++ +
tr|F6RCB6|F6RCB6_MACMU 630 STE--HPPFYYNIHR-HSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSI 689
333..6788888887.56889***********************************9888766 PP
>> sp|F7GSQ4|TRM5_MACMU tRNA (guanine(37)-N1)-methyltransferase OS=Macaca mulatta OX=9544 GN=TRMT5 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.6 0.0 6.3e-06 0.034 54 115 .. 303 361 .. 241 370 .. 0.80
Alignments for each domain:
== domain 1 score: 13.6 bits; conditional E-value: 6.3e-06
EESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC CS
TRM 54 ldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla 115
+d +++ G ai a+ +v+aND++++ + + +N kln+v++ v+i + d + +l+
sp|F7GSQ4|TRM5_MACMU 303 FDVFAGVGPFAIPVAKK---NCTVFANDLNPESHKWLLHNCKLNKVDQKVKIFNLDGKDFLQ 361
56666666666666655...568************************999998889888776 PP
>> tr|A0A1I7Q472|A0A1I7Q472_MACMU tRNA (guanine(37)-N1)-methyltransferase OS=Macaca mulatta OX=9544 GN=TRMT5 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.5 0.0 6.7e-06 0.035 55 115 .. 283 340 .. 232 349 .. 0.81
Alignments for each domain:
== domain 1 score: 13.5 bits; conditional E-value: 6.7e-06
ESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC CS
TRM 55 daLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla 115
d +++ G ai a+ +v+aND++++ + + +N kln+v++ v+i + d + +l+
tr|A0A1I7Q472|A0A1I7Q472_MACMU 283 DVFAGVGPFAIPVAKK---NCTVFANDLNPESHKWLLHNCKLNKVDQKVKIFNLDGKDFLQ 340
5556666656665555...568************************999998889888776 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (376 nodes)
Target sequences: 21211 (10888574 residues searched)
Passed MSV filter: 682 (0.0321531); expected 424.2 (0.02)
Passed bias filter: 466 (0.0219697); expected 424.2 (0.02)
Passed Vit filter: 46 (0.00216869); expected 21.2 (0.001)
Passed Fwd filter: 5 (0.000235727); expected 0.2 (1e-05)
Initial search space (Z): 21211 [actual number of targets]
Domain search space (domZ): 4 [number of targets reported over threshold]
# CPU time: 0.32u 0.01s 00:00:00.33 Elapsed: 00:00:00.09
# Mc/sec: 45490.04
//
[ok]