# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file:                  pfam_list/TRM.hmm.txt
# target sequence database:        proteomes/Nematostella_vectensis.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query:       TRM  [M=376]
Accession:   PF02005.15
Description: N2,N2-dimethylguanosine tRNA methyltransferase
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence               Description
    ------- ------ -----    ------- ------ -----   ---- --  --------               -----------
   1.3e-133  446.3   0.0   1.6e-133  446.0   0.0    1.1  1  tr|A7RIG7|A7RIG7_NEMVE  tRNA (guanine(26)-N(2))-dimethyltrans
    7.4e-19   68.6   0.0    9.6e-19   68.2   0.0    1.2  1  tr|A7T796|A7T796_NEMVE  Predicted protein (Fragment) OS=Nemat
    1.1e-05   25.2   0.0    1.9e-05   24.5   0.0    1.4  2  tr|A7SVE3|A7SVE3_NEMVE  Predicted protein OS=Nematostella vec
    1.5e-05   24.8   0.0    1.8e-05   24.5   0.0    1.2  1  tr|A7SVE2|A7SVE2_NEMVE  Predicted protein OS=Nematostella vec
    1.5e-05   24.8   0.0    4.7e-05   23.2   0.0    1.6  2  tr|A7SY10|A7SY10_NEMVE  Predicted protein OS=Nematostella vec
      2e-05   24.4   0.0    2.4e-05   24.1   0.0    1.1  1  tr|A7RYK6|A7RYK6_NEMVE  Predicted protein OS=Nematostella vec
      2e-05   24.4   0.0    2.4e-05   24.1   0.0    1.1  1  tr|A7T8E8|A7T8E8_NEMVE  Predicted protein OS=Nematostella vec
    2.4e-05   24.1   0.0    3.8e-05   23.5   0.0    1.4  1  tr|A7SY09|A7SY09_NEMVE  Predicted protein OS=Nematostella vec
    8.3e-05   22.4   0.0    0.00011   22.0   0.0    1.1  1  tr|A7RHA8|A7RHA8_NEMVE  Predicted protein OS=Nematostella vec
    0.00046   19.9   0.2    0.00064   19.4   0.2    1.2  1  tr|A7SHN7|A7SHN7_NEMVE  Predicted protein (Fragment) OS=Nemat
  ------ inclusion threshold ------
        0.1   12.2   0.0       0.16   11.5   0.0    1.3  1  tr|A7SAF9|A7SAF9_NEMVE  Predicted protein OS=Nematostella vec


Domain annotation for each sequence (and alignments):
>> tr|A7RIG7|A7RIG7_NEMVE  tRNA (guanine(26)-N(2))-dimethyltransferase OS=Nematostella vectensis OX=45351 GN=v1g238527 P
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  446.0   0.0  7.2e-137  1.6e-133       1     376 []      20     440 ..      20     440 .. 0.94

  Alignments for each domain:
  == domain 1  score: 446.0 bits;  conditional E-value: 7.2e-137
                             TTEEEEE----SS--TT--SS--GGGHHHHHHHHHH...HHHHHHHH-S-........................EEEEESS-TTSHH CS
                     TRM   1 GeakikvedkevtvskkeeVFYNPvqefnRDlsvlvirqlellkkklgek........................ikvldaLsasGlR 63 
                             G+++i++ ++e+++++++ VFYNPvqefnRD+s +vir +  +  k++++                        +++l++L+asGlR
  tr|A7RIG7|A7RIG7_NEMVE  20 GKTRIREGKAEIIFPAEKAVFYNPVQEFNRDISSAVIRLVCEDIDKWTKRrndekgdadkltraekrakdnlaqVTILEGLAASGLR 106
                             88999999999***************************55555555555569999******************************** PP

                             HHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC....--SS-EEEEEE--SS--GGGHHHHHHHEEEE CS
                     TRM  64 aiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla....ekkkrfdviDlDPfGspapfldsavqsvkek 146
                             ++R+alEvpg ++v+aNDis  A  li++Nvk n+v++iv ++++dA++l++      ++rf +iDlDP+G++apfld avq+v+++
  tr|A7RIG7|A7RIG7_NEMVE 107 SVRYALEVPGIHHVIANDISADAFSLIENNVKHNKVNHIVSASKNDASLLMYqyryPASRRFTFIDLDPYGTAAPFLDGAVQAVADG 193
                             ****************************************************8887789**************************** PP

                             EEEEEEE--HHHHTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHH CS
                     TRM 147 glLlvTaTDtavLaGaspekclrkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvl 233
                             g+LlvT+TD+ vL+G+++++c+ kYg+++lk ++cHE+alR+ll++++++a++Y++++ plls+s+dfY+rvfv+v t+a +vk+++
  tr|A7RIG7|A7RIG7_NEMVE 194 GVLLVTCTDMGVLCGNHNDACYGKYGGMSLKAKFCHEMALRLLLSSIESHANRYKRYILPLLSMSVDFYIRVFVQVFTSASEVKRTA 280
                             *************************************************************************************** PP

                             TTEEEEEEETTT.......--EEEE--GGG--..........SB-TTT-SBEEEEEEEE-S-S--HHHHHHHHHHHCT..-TTS.-H CS
                     TRM 234 eklglvlhCsgC.......lseekvkglakfk..........aecehcgaklhlaGPlwlgplkdkefveevleeaekekeeel.kk 302
                             +k+ lv+hC+gC       + ++ ++g+ k k          + c +cg k+hl+GP+w +p++d++fv+++++ ++++++    + 
  tr|A7RIG7|A7RIG7_NEMVE 281 SKQSLVYHCTGCgsfhfqqVGRRIEEGVSK-KyppalgppvdRSCDQCGGKFHLGGPIWTEPMHDTDFVTSLAALVKQNTDLYKtSD 366
                             ************998877633344445444.24677888888***********************************98754335** PP

                             HHHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHHHH CS
                     TRM 303 rvkklLklikeElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvevlr 376
                             r+ +lL+++ eEl+ +pl++++++l++v+++s+p+  +++sal++lg++vs++H++p+a+kT+ap +++++v+r
  tr|A7RIG7|A7RIG7_NEMVE 367 RIIGLLSMVAEELPTVPLFHTIDHLSNVIHCSSPSIVQFRSALLRLGYKVSGSHVCPTAVKTDAPNNVLWDVMR 440
                             *************************************************************************7 PP

>> tr|A7T796|A7T796_NEMVE  Predicted protein (Fragment) OS=Nematostella vectensis OX=45351 GN=v1g3263 PE=3 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.2   0.0   4.3e-22   9.6e-19     304     376 .]       1      73 [.       1      73 [. 0.98

  Alignments for each domain:
  == domain 1  score: 68.2 bits;  conditional E-value: 4.3e-22
                             HHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHHHH CS
                     TRM 304 vkklLklikeElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvevlr 376
                             + +lL+++ eEl+ +pl++++++l++v+++s+p+  +++sal++lg++vs++H++p+a+kT+ap +++++v+r
  tr|A7T796|A7T796_NEMVE   1 ISGLLSMVAEELPTVPLFHTIDHLSNVIHCSSPSIVQFRSALLRLGYKVSGSHVCPTAVKTDAPNNVLWDVMR 73 
                             679*********************************************************************7 PP

>> tr|A7SVE3|A7SVE3_NEMVE  Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g218064 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       1.6   3.6e+03     320     357 ..       5      40 ..       2      46 .. 0.74
   2 !   24.5   0.0   8.4e-09   1.9e-05      43     109 ..      67     132 ..      13     148 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.6
                             S-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TT CS
                     TRM 320 lyydlsqlasvlklsvpplkkvvsalkelgfevsrtHa 357
                              ++d+++  +++++s+  +k+v   +++ g+ vs t +
  tr|A7SVE3|A7SVE3_NEMVE   5 SFFDTNAAVEKMRISSHTKKRVT--INQRGYVVSPTVF 40 
                             68888888888888888888774..6678888887755 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 8.4e-09
                             HHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S- CS
                     TRM  43 lkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvinedd 109
                             +k+++++ +k l+  ++ G  ai fal vp+  ev+a Di++ Ave + eN+ l+ ve+ v++ ++d
  tr|A7SVE3|A7SVE3_NEMVE  67 QKSNTESSLKFLEVGAGMGAIAIEFALQVPQ-AEVWATDINPAAVEDVAENACLHGVENSVTAIQAD 132
                             33334556999*****************886.58************************988877755 PP

>> tr|A7SVE2|A7SVE2_NEMVE  Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g218063 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.5   0.0   8.3e-09   1.8e-05      43     109 ..      67     132 ..       8     148 .. 0.80

  Alignments for each domain:
  == domain 1  score: 24.5 bits;  conditional E-value: 8.3e-09
                             HHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S- CS
                     TRM  43 lkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvinedd 109
                             +k+++++ +k l+  ++ G  ai fal vp+  ev+a Di++ Ave + eN+ l+ ve+ v++ ++d
  tr|A7SVE2|A7SVE2_NEMVE  67 QKSNTESSLKFLEVGAGMGAIAIEFALQVPQ-AEVWATDINPAAVEDVAENACLHGVENSVTAIQAD 132
                             33444566999*****************886.58************************988877755 PP

>> tr|A7SY10|A7SY10_NEMVE  Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g219300 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.55   1.2e+03     319     358 ..       4      41 ..       1      58 [. 0.81
   2 !   23.2   0.0   2.1e-08   4.7e-05      44     109 ..      68     132 ..      52     148 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.55
                             SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTS CS
                     TRM 319 plyydlsqlasvlklsvpplkkvvsalkelgfevsrtHak 358
                               ++d+++  +++++s++ +k+v   +++ g+ vs t + 
  tr|A7SY10|A7SY10_NEMVE   4 ISFFDTNAAVEKMRISSQTKKRVT--INQRGYVVSPTVFD 41 
                             679999999999999999888875..67788888887665 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 2.1e-08
                             HHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S- CS
                     TRM  44 kkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvinedd 109
                             k+++++ +k l+  ++ G  ai fal vp+  ev+a Di++ Ave + eN+ l+ v++ v++ ++d
  tr|A7SY10|A7SY10_NEMVE  68 KSNTESSLKFLEVGAGMGAIAIEFALQVPQ-AEVWATDINPAAVEDVAENACLHGVANSVTAIQAD 132
                             33345569999999*************886.58************************988877755 PP

>> tr|A7RYK6|A7RYK6_NEMVE  Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g241579 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.0   1.1e-08   2.4e-05      43     110 ..      67     133 ..      18     154 .. 0.81

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 1.1e-08
                             HHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-H CS
                     TRM  43 lkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddA 110
                             +k+++++ +k l+  ++ G  ai fal vp+  ev+a Di++ Av+ + eN++l+ ve  v++ ++d 
  tr|A7RYK6|A7RYK6_NEMVE  67 QKSNTESSLKFLEVGAGMGAIAIEFALQVPQ-AEVWATDINPAAVDDVAENARLHGVETSVTAIQADV 133
                             33444566999***9*************886.58************************9887777564 PP

>> tr|A7T8E8|A7T8E8_NEMVE  Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g223766 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.0   1.1e-08   2.4e-05      43     110 ..      67     133 ..      18     154 .. 0.81

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 1.1e-08
                             HHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-H CS
                     TRM  43 lkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddA 110
                             +k+++++ +k l+  ++ G  ai fal vp+  ev+a Di++ Av+ + eN++l+ ve  v++ ++d 
  tr|A7T8E8|A7T8E8_NEMVE  67 QKSNTESSLKFLEVGAGMGAIAIEFALQVPQ-AEVWATDINPAAVDDVAENARLHGVETSVTAIQADV 133
                             33444566999***9*************886.58************************9887777564 PP

>> tr|A7SY09|A7SY09_NEMVE  Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g248028 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.0   1.7e-08   3.8e-05      50     109 ..      68     132 ..      10     148 .. 0.78

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 1.7e-08
                             -......EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S- CS
                     TRM  50 k......ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvinedd 109
                             k      +k l+  ++ G  ai fal vp+  ev+a Di++ Ave + eN+ l+ ve+ v++ ++d
  tr|A7SY09|A7SY09_NEMVE  68 KsdtesfLKFLEVGAGMGAIAIEFALQVPQ-AEVWATDINPAAVEDVAENACLHGVENSVTAIQAD 132
                             033334489999999************886.58************************988877755 PP

>> tr|A7RHA8|A7RHA8_NEMVE  Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g197133 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.0     5e-08   0.00011      38     109 ..      60     131 ..      19     146 .. 0.88

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 5e-08
                             ...HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S- CS
                     TRM  38 r.qlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvinedd 109
                             r   e ++kk ge + +l+   ++Gl +i  al  +++ +v+a D+++ Av+   eN+kl+ v++ v + ++d
  tr|A7RHA8|A7RHA8_NEMVE  60 RvLAEEMDKKPGEAFALLEIGCGTGLTSIMAALY-SKKCQVWATDVNPSAVKNTAENAKLHGVDNQVRTATGD 131
                             55567788999999******************98.9999*************************988887776 PP

>> tr|A7SHN7|A7SHN7_NEMVE  Predicted protein (Fragment) OS=Nematostella vectensis OX=45351 GN=v1g118817 PE=3 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.2   2.9e-07   0.00064      55     137 ..     225     312 ..     169     315 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2.9e-07
                             ESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HH.HHHC.......--SS-EEEEEE--SS--G CS
                     TRM  55 daLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAn.vlla.......ekkkrfdviDlDPfGspa 133
                             d +++ G  ai  a+       v+aND+++   + +++N+k n+v++++++ + d + ++++       e++k f+++ +    ++ 
  tr|A7SHN7|A7SHN7_NEMVE 225 DMFAGVGPFAIPAAKK---GCFVYANDLNPSSFKALEHNAKTNQVADRIKAFNLDGReFVMQvtentlkENNKMFNHVVMNLPATAL 308
                             5555555555555554...5679***********************97776666665155658888888889999999888878888 PP

                             GGHH CS
                     TRM 134 pfld 137
                             +fld
  tr|A7SHN7|A7SHN7_NEMVE 309 QFLD 312
                             8887 PP

>> tr|A7SAF9|A7SAF9_NEMVE  Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g243959 PE=4 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   7.3e-05      0.16      53     114 ..      56     114 ..      28     132 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 7.3e-05
                             EEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHH CS
                     TRM  53 vldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvll 114
                             ++da+ + G  ai fa      ++v+a Di +  +++ ++N+++  v++++++  +d + ++
  tr|A7SAF9|A7SAF9_NEMVE  56 IVDAFCGVGGNAIQFAFT---CERVIAIDIDPVKIDCARHNAEIYGVADRIEFVLGDFRQIV 114
                             89**************88...789999**********************9999988877666 PP



Internal pipeline statistics summary:
-------------------------------------
Query model(s):                              1  (376 nodes)
Target sequences:                        24428  (8257945 residues searched)
Passed MSV filter:                       784  (0.0320943); expected 488.6 (0.02)
Passed bias filter:                      505  (0.020673); expected 488.6 (0.02)
Passed Vit filter:                        39  (0.00159653); expected 24.4 (0.001)
Passed Fwd filter:                        11  (0.000450303); expected 0.2 (1e-05)
Initial search space (Z):              24428  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.24u 0.01s 00:00:00.25 Elapsed: 00:00:00.07
# Mc/sec: 44356.96
//
[ok]