# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/TRM.hmm.txt
# target sequence database: proteomes/Pan_troglodytes.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: TRM [M=376]
Accession: PF02005.15
Description: N2,N2-dimethylguanosine tRNA methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
8.6e-152 506.0 0.0 1e-151 505.8 0.0 1.0 1 tr|H2R3Q5|H2R3Q5_PANTR tRNA (guanine(26)-N(2))-dimethyl
3.7e-75 253.8 0.1 1.6e-68 232.0 0.1 2.0 2 tr|A0A2I3S380|A0A2I3S380_PANTR tRNA (guanine(26)-N(2))-dimethyl
5.4e-66 223.7 3.4 1.1e-55 189.7 0.4 3.1 3 tr|G2HHV3|G2HHV3_PANTR N2,N2-dimethylguanosine tRNA met
------ inclusion threshold ------
0.099 12.1 0.0 0.15 11.5 0.0 1.3 1 tr|H2Q8F0|H2Q8F0_PANTR tRNA (guanine(37)-N1)-methyltran
Domain annotation for each sequence (and alignments):
>> tr|H2R3Q5|H2R3Q5_PANTR tRNA (guanine(26)-N(2))-dimethyltransferase OS=Pan troglodytes OX=9598 GN=TRMT1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 505.8 0.0 1.7e-155 1e-151 12 376 .] 57 500 .. 45 500 .. 0.94
Alignments for each domain:
== domain 1 score: 505.8 bits; conditional E-value: 1.7e-155
SS.......--TT--SS--GGGHHHHHHHHHH........HHHHHHHH-S-.................................... CS
TRM 12 vt.......vskkeeVFYNPvqefnRDlsvlvi....r.qlellkkklgek.................................... 50
vt +++++eVFYNPvqefnRDl+++vi r ql +++ +++ +
tr|H2R3Q5|H2R3Q5_PANTR 57 VTegaakiaFPSANEVFYNPVQEFNRDLTCAVItefaRiQLGAKGIQIKVPgekdtqkvvvdlseqeeekvelkesenlasgdqprt 143
224455556***********************977766666777777766699********************************** PP
..........EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC...--SS-EEEE CS
TRM 51 ..........ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla...ekkkrfdvi 124
++vl++L+asGlR+iRfalEvpg ++v+aND+s++Av+li++Nv+ln+v+++v+++++dA++l++ ++++rfdvi
tr|H2R3Q5|H2R3Q5_PANTR 144 aavgeiceegLHVLEGLAASGLRSIRFALEVPGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYqhqRVSERFDVI 230
***************************************************************************8877889***** PP
EE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEE CS
TRM 125 DlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalkselcHEvalRillkavareaakYekavepllsls 211
DlDP+Gspa+fld+avq+v+e+glL+vT+TD+avLaG+s e+c++kYga+alks++cHE+alRi+l++++ +a++Y+++v+plls+s
tr|H2R3Q5|H2R3Q5_PANTR 231 DLDPYGSPATFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDLRANCYQRFVVPLLSIS 317
*************************************************************************************** PP
ETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT.........--EEEE--GGG--........SB-TTT-SBEEEEEEEE-S-S-- CS
TRM 212 adfYvrvfvkvktgaakvkkvleklglvlhCsgC.........lseekvkglakfk........aecehcgaklhlaGPlwlgplkd 281
adfYvrvfv+v tg+akvk++++k++lv++C+gC +++ +g+ kf+ ecehcg++++l+GP+w++p++d
tr|H2R3Q5|H2R3Q5_PANTR 318 ADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCgafhlqrlgKASGVPSGRVKFSaacgppvtPECEHCGQRHQLGGPMWAEPIHD 404
*************************************9888764448889999999******************************* PP
HHHHHHHHHHHCT..-TTS..-HHHHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS CS
TRM 282 kefveevleeaekekeeel..kkrvkklLklikeElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTna 366
+fv++vle+++++ ++ ++r++++L++i+eEl+d+plyy+l+ql+s++++++p+l +++sal++++f+vs++Ha+++a+kT+a
tr|H2R3Q5|H2R3Q5_PANTR 405 LDFVGRVLEAVSANP-GRFhtSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDA 490
*************75.44445****************************************************************** PP
-HHHHHHHHH CS
TRM 367 pleavvevlr 376
p++a+++++r
tr|H2R3Q5|H2R3Q5_PANTR 491 PASALWDIMR 500
*********7 PP
>> tr|A0A2I3S380|A0A2I3S380_PANTR tRNA (guanine(26)-N(2))-dimethyltransferase OS=Pan troglodytes OX=9598 PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 19.8 0.0 8.3e-08 0.00048 50 75 .. 96 144 .. 60 148 .. 0.75
2 ! 232.0 0.1 2.8e-72 1.6e-68 105 365 .. 164 416 .. 156 423 .. 0.92
Alignments for each domain:
== domain 1 score: 19.8 bits; conditional E-value: 8.3e-08
-.......................EEEEESS-TTSHHHHHHHHH-S-EE CS
TRM 50 k.......................ikvldaLsasGlRaiRfalEvpgvk 75
k ++vl++L+asGl +iRfalEvpg++
tr|A0A2I3S380|A0A2I3S380_PANTR 96 KgsenlasgdqprtatvweiceegLHVLEGLAASGLLSIRFALEVPGAQ 144
266666666667777777777777*********************9875 PP
== domain 2 score: 232.0 bits; conditional E-value: 2.8e-72
EE-S-HHHHHC...--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB---STT CS
TRM 105 ineddAnvlla...ekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalksel 180
+++ d +l++ ++++rfdv lDP+Gspapfld+av +v+e+ lL+vT TDtavLa +s e c++k+ga+alks++
tr|A0A2I3S380|A0A2I3S380_PANTR 164 PSQVDGWMLMYqhqRVSERFDVTHLDPYGSPAPFLDAAVLAVSEGELLCVTRTDTAVLARNSGEMCYSKFGAMALKSRA 242
56789999**98777889************************************************************* PP
HHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT--EEEE--GGG--S CS
TRM 181 cHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsgClseekvkglakfka 259
cHE+alRi+l++++ +a++Y+++v+plls+sadfYvrvfv+v tg+ kvk+++ +g +++ g+ k +
tr|A0A2I3S380|A0A2I3S380_PANTR 243 CHEMALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQPKVKASAMGCGSFHLQRLGKASGVPRGRVKSSV 321
****************************************************999998766344455589999999885 PP
B-.TTT-SBEEEEEEEE-S-S--HHHHHHHHHHHCT..-TTS-HHHHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS-- CS
TRM 260 ec.ehcgaklhlaGPlwlgplkdkefveevleeaekekeeelkkrvkklLklikeElldaplyydlsqlasvlklsvpp 337
c ehcg++++l+ +w++p++d +fv+ vle+++++ + ++ ++ ++L++++eE l +l+s++ +++p+
tr|A0A2I3S380|A0A2I3S380_PANTR 322 ACrEHCGQRHQLGCSMWAEPIHDLDFVGCVLEAVSAN-PGRF--HTSEVLSVMTEE---------LPELSSTILCHTPS 388
5538*******************************94.6666..46799*******.........889*********** PP
-HHHHHHH....TT-EE-TTSTTEEE-S CS
TRM 338 lkkvvsalkelgfevsrtHakpkaikTn 365
l ++sal+++ f+vs++Ha+++a+kT
tr|A0A2I3S380|A0A2I3S380_PANTR 389 LLPLRSALLHAHFRVSLSHACKNAVKTY 416
**************************95 PP
>> tr|G2HHV3|G2HHV3_PANTR N2,N2-dimethylguanosine tRNA methyltransferase-like protein OS=Pan troglodytes OX=9598 GN=TRM
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -1.3 0.1 0.21 1.2e+03 230 246 .. 174 200 .. 168 223 .. 0.65
2 ! 189.7 0.4 1.9e-59 1.1e-55 12 292 .. 242 548 .. 226 571 .. 0.86
3 ! 32.9 0.0 8.7e-12 5e-08 313 374 .. 629 687 .. 590 689 .. 0.79
Alignments for each domain:
== domain 1 score: -1.3 bits; conditional E-value: 0.21
HHHHTTEEEEEEETTT..........- CS
TRM 230 kkvleklglvlhCsgC..........l 246
+++++k+g +hC+ C l
tr|G2HHV3|G2HHV3_PANTR 174 EQITSKMGAHYHCIICsatitrrtdmL 200
78899***********66543333320 PP
== domain 2 score: 189.7 bits; conditional E-value: 1.9e-59
SS--TT--SS--GGGHHHHHHHHHH...HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT CS
TRM 12 vtvskkeeVFYNPvqefnRDlsvlvirqlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklne 98
+++k++ ++NP ++ nR l + l++l ++ ++++ lda+ a+G+ ++ +a+ + ++ +v +ND++e+ v li+eN +ln+
tr|G2HHV3|G2HHV3_PANTR 242 YSIPQKTDSYFNPKMKLNRQLIFCT---LAALAEE-RKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNK 324
3499999**************9888...5666655.589*******************************************99999 PP
--......................GGEEEE-S-HHHHHC--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSS CS
TRM 99 ve......................eivvineddAnvllaekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtavLaGas 163
+ +++ ++dAnvl+ + + fd+i lDPfG+++++ldsa + +++ g+++vT+TD ++L ++
tr|G2HHV3|G2HHV3_PANTR 325 LKvvvdskekeksddileegeknlGNIKVTKMDANVLM--HLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKA 409
8888999999999*999999987636999999******..7899******************************************* PP
HHHHHHHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT..... CS
TRM 164 pekclrkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsgC..... 245
++ r+Yg + +++e++ E a Ri++ avar+aa+ +k +e+l++++ +++v v v+v +g++ ++++++k+ +++hC C
tr|G2HHV3|G2HHV3_PANTR 410 QHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCeerif 496
**********************************************************************************66654 PP
.....--EEEE--GGG--........SB-TTT-SBEEEEEEEE-S-S--HHHHHHHHHHH CS
TRM 246 .....lseekvkglakfk........aecehcgaklhlaGPlwlgplkdkefveevleea 292
+ + + + + g++ GPlw l ++ f++++l e
tr|G2HHV3|G2HHV3_PANTR 497 qkdgnM-----VEE---NpyrqlpcnCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFES 548
332222.....222...1333444213334456666778****************98654 PP
== domain 3 score: 32.9 bits; conditional E-value: 8.7e-12
HHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHH CS
TRM 313 eElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvev 374
+ p+yy++++ s+ +++p+lkk+ l ++gf+vsrtH+ p +++T+apl ++ +
tr|G2HHV3|G2HHV3_PANTR 629 T--EHPPFYYNIHR-HSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSI 687
2..36788888887.56889***********************************9888766 PP
>> tr|H2Q8F0|H2Q8F0_PANTR tRNA (guanine(37)-N1)-methyltransferase OS=Pan troglodytes OX=9598 GN=TRMT5 PE=3 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.5 0.0 2.6e-05 0.15 55 115 .. 303 360 .. 240 369 .. 0.80
Alignments for each domain:
== domain 1 score: 11.5 bits; conditional E-value: 2.6e-05
ESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC CS
TRM 55 daLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla 115
d +++ G ai a+ +v+aND++++ + + N kln+v++ v++ + d + +l+
tr|H2Q8F0|H2Q8F0_PANTR 303 DVFAGVGPFAIPVAKK---NCTVFANDLNPESHKWLLYNCKLNKVDQKVKVFNLDGKDFLQ 360
5556666666666555...568************************988887778887775 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (376 nodes)
Target sequences: 23008 (11942255 residues searched)
Passed MSV filter: 740 (0.0321627); expected 460.2 (0.02)
Passed bias filter: 516 (0.022427); expected 460.2 (0.02)
Passed Vit filter: 44 (0.00191238); expected 23.0 (0.001)
Passed Fwd filter: 4 (0.000173853); expected 0.2 (1e-05)
Initial search space (Z): 23008 [actual number of targets]
Domain search space (domZ): 4 [number of targets reported over threshold]
# CPU time: 0.32u 0.01s 00:00:00.33 Elapsed: 00:00:00.12
# Mc/sec: 37419.07
//
[ok]