# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/TRM.hmm.txt
# target sequence database: proteomes/Saccharomyces_cerevisiae.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: TRM [M=376]
Accession: PF02005.15
Description: N2,N2-dimethylguanosine tRNA methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
4.1e-158 524.9 0.0 4.7e-158 524.7 0.0 1.0 1 sp|P15565|TRM1_YEAST tRNA (guanine(26)-N(2))-dimethyltransfe
0.00021 19.1 0.0 0.00032 18.4 0.0 1.3 1 sp|P53944|MTQ1_YEAST Mitochondrial N(5)-glutamine methyltran
0.00042 18.0 0.0 0.00072 17.3 0.0 1.3 1 sp|P38793|TRM5_YEAST tRNA (guanine(37)-N1)-methyltransferase
0.0056 14.3 0.0 0.0083 13.8 0.0 1.3 1 sp|P38347|EFM2_YEAST Protein-lysine N-methyltransferase EFM2
Domain annotation for each sequence (and alignments):
>> sp|P15565|TRM1_YEAST tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 524.7 0.0 3.1e-161 4.7e-158 1 376 [] 33 490 .. 33 490 .. 0.96
Alignments for each domain:
== domain 1 score: 524.7 bits; conditional E-value: 3.1e-161
TTEEEEE----SS........--TT--SS--GGGHHHHHHHHHH....HHHHHHHH-S-.............................. CS
TRM 1 Geakikvedkevt........vskkeeVFYNPvqefnRDlsvlvir.qlellkkklgek.............................. 50
G+ +i++ed++++ ++kke+VFYNP+q+fnRDlsv++i+ + +l+++++g+k
sp|P15565|TRM1_YEAST 33 GAPRINIEDFNIVkegkaeilFPKKETVFYNPIQQFNRDLSVTCIKaWDNLYGEECGQKrnnkkskkkrcaetnddsskrqkmgngspk 121
778899999987778999999******************************************************************** PP
............EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC...--SS-EEEE CS
TRM 51 ............ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneveeivvineddAnvlla...ekkkrfdvi 124
i++l+aLsa+GlRaiR+a+E+p+v+ev+aND++++Ave+ik+Nv++n+ve+iv++n ddAnvl++ +++++f+vi
sp|P15565|TRM1_YEAST 122 eavgnsnrnepyINILEALSATGLRAIRYAHEIPHVREVIANDLLPEAVESIKRNVEYNSVENIVKPNLDDANVLMYrnkATNNKFHVI 210
*****************************************************************************8888899***** PP
EE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTT.SSHHHHHHHHS.SB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEE CS
TRM 125 DlDPfGspapfldsavqsvkekglLlvTaTDtavLaG.aspekclrkYg.avalkselcHEvalRillkavareaakYekavepllsls 211
DlDP+G+++pf+d+a+qs++e+gl+lvT+TD++vLaG +pekc++ Yg a+++++e++HE+alR++l++++++aakY+k+vepllsls
sp|P15565|TRM1_YEAST 211 DLDPYGTVTPFVDAAIQSIEEGGLMLVTCTDLSVLAGnGYPEKCFALYGgANMVSHESTHESALRLVLNLLKQTAAKYKKTVEPLLSLS 299
*************************************88*********989************************************** PP
ETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT.............--E.EEE--GGG--........SB-TTT-SBEEEEEEEE-S- CS
TRM 212 adfYvrvfvkvktgaakvkkvleklglvlhCsgC.............lse.ekvkglakfk........aecehcgaklhlaGPlwlgp 278
+dfYvrvfvkvkt++++vk+v++++++++hCs+C + e +++k+++k++ ++c++c+ ++hlaGP+++gp
sp|P15565|TRM1_YEAST 300 IDFYVRVFVKVKTSPIEVKNVMSSTMTTYHCSRCgsyhnqplgrisqR-EgRNNKTFTKYSvaqgppvdTKCKFCEGTYHLAGPMYAGP 387
*****************************************9996543.258899999999**************************** PP
S--HHHHHHHHHHHCT.....-TTS..-HHHHHHHHHHHHHHS--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEE CS
TRM 279 lkdkefveevleeaekek...eeel..kkrvkklLklikeElldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkai 362
l++kef+eevl+++++e+ ++++ +kr++++L+l+k+El+d+p+y++ +++asv+kl+vpplkkvv++l +lgfe+s+tHa+p+++
sp|P15565|TRM1_YEAST 388 LHNKEFIEEVLRINKEEHrdqDDTYgtRKRIEGMLSLAKNELSDSPFYFSPNHIASVIKLQVPPLKKVVAGLGSLGFECSLTHAQPSSL 476
***************9986644455999************************************************************* PP
E-SS-HHHHHHHHH CS
TRM 363 kTnapleavvevlr 376
kTnap++a+++v++
sp|P15565|TRM1_YEAST 477 KTNAPWDAIWYVMQ 490
************96 PP
>> sp|P53944|MTQ1_YEAST Mitochondrial N(5)-glutamine methyltransferase MTQ1 OS=Saccharomyces cerevisiae (strain ATCC 20
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 18.4 0.0 2.1e-07 0.00032 34 105 .. 94 167 .. 85 184 .. 0.83
Alignments for each domain:
== domain 1 score: 18.4 bits; conditional E-value: 2.1e-07
HHH....HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--..GGEEE CS
TRM 34 vlvir.qlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneve..eivvi 105
+++ir + + ++ + ++++ d+++++G a+ ++ +++ a D+s++A++l+keN+ n+v+ ++v+
sp|P53944|MTQ1_YEAST 94 MAIIRaLNNSMLSRHTIPLHICDTFTGTGCIALALSHGIANCTFT-AIDVSTRAIKLVKENMLKNKVSggKLVQH 167
67788777888889999*********************9998765.58*************99999996534443 PP
>> sp|P38793|TRM5_YEAST tRNA (guanine(37)-N1)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 17.3 0.0 4.8e-07 0.00072 77 115 .. 303 341 .. 282 349 .. 0.88
Alignments for each domain:
== domain 1 score: 17.3 bits; conditional E-value: 4.8e-07
EEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HHHHHC CS
TRM 77 vlaNDisekAvelikeNvklneveeivvineddAnvlla 115
vlaND++++ ++ +keN+ ln+v+++v++ ++d + +++
sp|P38793|TRM5_YEAST 303 VLANDLNPESYKYLKENIALNKVAKTVKSFNMDGADFIR 341
79***********************99999999877776 PP
>> sp|P38347|EFM2_YEAST Protein-lysine N-methyltransferase EFM2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 13.8 0.0 5.5e-06 0.0083 40 128 .. 244 342 .. 165 350 .. 0.80
Alignments for each domain:
== domain 1 score: 13.8 bits; conditional E-value: 5.5e-06
HHHHHHHH-S-EEEEESS-TTSHHHHHHH...HH-S-EE..EEEEE-S-HHHHHHHHHHHHHTT--GGEEEE-S-HH...HHHC..--S CS
TRM 40 lellkkklgekikvldaLsasGlRaiRfa...lEvpgvk..evlaNDisekAvelikeNvklneveeivvineddAn...vlla..ekk 118
+++l + ++ikvl+ +++Gl ++ +a +E+ g++ e+++ D+ ++ v +k+Nv+ln+ + v+++ d + ++ ++
sp|P38347|EFM2_YEAST 244 VNMLANSDIKQIKVLELGAGTGLVGLSWAlkwKELYGTEniEIFVTDL-PEIVTNLKKNVSLNNLGDFVQAEILDWTnphDFIDkfGHE 331
44555555677******************7777887766336899997.7899*************99988776643111344456677 PP
S-EEEEEE.-- CS
TRM 119 krfdviDl.DP 128
++fdvi + DP
sp|P38347|EFM2_YEAST 332 NEFDVILIaDP 342
77777755455 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (376 nodes)
Target sequences: 6049 (2936363 residues searched)
Passed MSV filter: 252 (0.0416598); expected 121.0 (0.02)
Passed bias filter: 154 (0.0254588); expected 121.0 (0.02)
Passed Vit filter: 15 (0.00247975); expected 6.0 (0.001)
Passed Fwd filter: 4 (0.000661266); expected 0.1 (1e-05)
Initial search space (Z): 6049 [actual number of targets]
Domain search space (domZ): 4 [number of targets reported over threshold]
# CPU time: 0.09u 0.00s 00:00:00.09 Elapsed: 00:00:00.03
# Mc/sec: 36802.42
//
[ok]