# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/TRM.hmm.txt
# target sequence database: proteomes/Tetrahymena_thermophila.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: TRM [M=376]
Accession: PF02005.15
Description: N2,N2-dimethylguanosine tRNA methyltransferase
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
5.5e-100 335.8 0.5 7.6e-100 335.3 0.5 1.1 1 tr|Q22HL7|Q22HL7_TETTS tRNA (guanine(26)-N(2))-dimethyltrans
2.6e-55 188.7 5.2 3.8e-55 188.2 5.2 1.2 1 tr|W7X4C4|W7X4C4_TETTS tRNA (guanine(26)-N(2))-dimethyltrans
0.0027 17.5 0.0 0.0058 16.4 0.0 1.5 1 tr|W7XD08|W7XD08_TETTS tRNA (guanine(37)-N1)-methyltransfera
Domain annotation for each sequence (and alignments):
>> tr|Q22HL7|Q22HL7_TETTS tRNA (guanine(26)-N(2))-dimethyltransferase OS=Tetrahymena thermophila (strain SB210) OX=3120
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 335.3 0.5 8.5e-104 7.6e-100 18 376 .] 108 505 .. 92 505 .. 0.91
Alignments for each domain:
== domain 1 score: 335.3 bits; conditional E-value: 8.5e-104
--SS--GGGHHHHHHHHHH....HHHHHHHH-S-...EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT-- CS
TRM 18 eeVFYNPvqefnRDlsvlvir.qlellkkklgek...ikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklneve 100
+eVFYNPvq fnRDl+vlvi+ + e+lk+ +ek i++ldaLsasGlRaiRf++E++ k+v+aNDise +l+ N+ ln+ +
tr|Q22HL7|Q22HL7_TETTS 108 SEVFYNPVQVFNRDLTVLVIHmFKEYLKETRKEKfdgITILDALSASGLRAIRFSKELKDIKKVYANDISEASHKLMMDNFILNNLD 194
58******************966677766666668889************************************************9 PP
.GGEEEE-S-HHHHHC.........--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHHHHHSSB--- CS
TRM 101 .eivvineddAnvlla.........ekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspekclrkYgavalk 177
+++ +dA l++ ++ rfdviDlDP+G+ apfld a+q + + lL++T+TD+ L+G ++kc+ Yg++ k
tr|Q22HL7|Q22HL7_TETTS 195 lSKIEMTLKDAVQLMYeqkfrsssgDRNARFDVIDLDPYGTCAPFLDCAIQGAVGETLLCITSTDSRILCGPDTQKCYYLYGSSRAK 281
7689************9999988888899********************************************************** PP
STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT...............--EE CS
TRM 178 selcHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsgC...............lsee 249
++ E a+Ri+l++ ++ a++Y k+++pll+++++fYvrvf+ +k g+ + ++l ++g v+hC +C
tr|Q22HL7|Q22HL7_TETTS 282 IAAYEENAVRIILYTANNIANRYGKFITPLLCYMSEFYVRVFLIIKPGKLECGRSLVRTGNVFHCDNCqnqyfqtfgkqskakQ--- 365
********************************************************************7777666655433320... PP
EE--GGG--..............SB-TTT-SBEEEEEEEE-S-S--HHHHHHHHHHHCT.....-TTS-HHHHHHHHHHHHHH.... CS
TRM 250 kvkglakfk..............aecehcgaklhlaGPlwlgplkdkefveevleeaekek...eeelkkrvkklLklikeEl.... 315
+ + c++cg+++ + GP+w ++l+d+ef+++ ++ ++++k + ++kk+++++L+ i+ E
tr|Q22HL7|Q22HL7_TETTS 366 --------SdaqkhvpqklnlpsNICNQCGESFTINGPIWTDKLNDQEFIQKTIDYLNSDKfdlPLATKKKIEGMLHSIQLEQkagv 444
........13334456667788799******************************9999877666777***********99864443 PP
S--SS-EEHHHHHHHHT-SS---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHHHH CS
TRM 316 ldaplyydlsqlasvlklsvpplkkvvsalkelgfevsrtHakpkaikTnapleavvevlr 376
+ pl ++ ++l++++k++vp++kk+ sa+k+l++ + +t ++p kTnap e v +v+r
tr|Q22HL7|Q22HL7_TETTS 445 DNIPLGFNFEHLSKMMKTTVPSKKKIFSAIKSLNYSIEQTYLNPAIYKTNAPSEIVFDVIR 505
5789******************************************************986 PP
>> tr|W7X4C4|W7X4C4_TETTS tRNA (guanine(26)-N(2))-dimethyltransferase OS=Tetrahymena thermophila (strain SB210) OX=3120
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 188.2 5.2 4.2e-59 3.8e-55 14 376 .] 101 521 .. 83 521 .. 0.80
Alignments for each domain:
== domain 1 score: 188.2 bits; conditional E-value: 4.2e-59
--TT--SS--GGGHHHHHHHHHH....HHHHHHHH-S-...EEEEESS-TTSHHHHHHHHH-S-E..E..EEEEE-S-HHHHHHHHH CS
TRM 14 vskkeeVFYNPvqefnRDlsvlvir.qlellkkklgek...ikvldaLsasGlRaiRfalEvpgv..k..evlaNDisekAvelike 92
+++ + FYN vq + RD+++lv + +++ l+ g+ ++l++ ++sG++a+R+a+E++ + +v+ Di+ e k
tr|W7X4C4|W7X4C4_TETTS 101 KENHFKMFYNLVQLVERDITLLVANqYFKDLEITNGQSfkgARILQGKASSGVKALRYAKEIDPSyiQdiTVIEKDINFP--EYFKL 185
3455689***************985566555555555533378******************9864223225666777643..45555 PP
HHHHTT--.GGEEEE-S-HHHHHC..........--SS-EEEEEE--SS--GGGHHHHHHHEEEEEEEEEEE--HHHHTTSSHHHHH CS
TRM 93 Nvklneve.eivvineddAnvlla..........ekkkrfdviDlDPfGspapfldsavqsvkekglLlvTaTDtavLaGaspekcl 168
+++n+++ +i +++ n + + + +d+iD++ +Gs+ + + +a++ vk++g+++ TD+++L+G kc+
tr|W7X4C4|W7X4C4_TETTS 186 LAHYNDIDmSKFKIVNKETNHFYLskilenmdkyDQPELYDFIDIEEYGSSIDTIRQAIKLVKNGGMISAMFTDMSTLCGPNVIKCY 272
567888886344544445555433366666666667788************************************************ PP
HHHSSB---STTHHHHHHHHHHHHHHHHHHTTTEEEEEEEEEEETTEEEEEEEEEE-HHHHHHHHTTEEEEEEETTT.......... CS
TRM 169 rkYgavalkselcHEvalRillkavareaakYekavepllslsadfYvrvfvkvktgaakvkkvleklglvlhCsgC.......... 245
+ Y+ + ++ + E a+Ri+ +++ a++ + +ep++s+++dfY+++f++v+++ ++++k lekl lv++Cs+C
tr|W7X4C4|W7X4C4_TETTS 273 SSYNKFRIRLASLNENAIRIIYSTILDIATQNNYSIEPVVSFQSDFYIKIFFRVHHNGVESQKALEKLSLVYQCSECpnyhvhtiak 359
*****************************************************************************8888887666 PP
....--EEEE--GGG--....................SB-TTT-SBEEEEEEEE-S-S--HHHHHHHHHHHCT..-TTS........ CS
TRM 246 ....lseekvkglakfk....................aecehcgaklhlaGPlwlgplkdkefveevleeaekekeeel........ 300
+ e++ + +c+ c+++ l GPlw +pl++ +fv++vl++++++ +e++
tr|W7X4C4|W7X4C4_TETTS 360 vqqnTIENV-------QngtlklessmdlklnelkvpSNCNVCESSWILNGPLWNQPLHNYKFVQNVLRNLQSTGSEKVfsknkiml 439
554422233.......244444558888889999999**********************************9987444445444456 PP
...-HHHHHHHHHHHHHH..S--SS-EEHHHHHHHHT-SS.---HHHHHHH....TT-EE-TTSTTEEE-SS-HHHHHHHHH CS
TRM 301 ...kkrvkklLklikeEl..ldaplyydlsqlasvlklsv.pplkkvvsalkelgfevsrtHakpkaikTnapleavvevlr 376
+ ++ + L++i +E + l y+l + k ++ p ++++ +al ++g+ + r+ +++k kTnap +++ + +r
tr|W7X4C4|W7X4C4_TETTS 440 iqsHLKLTAYLEAILQEKefDKFILGYNLTLINGFYKAKTyPTTNHIKRALARAGYTINRSIFEKKIYKTNAPSNVIFDTMR 521
65555677889999988763445678*********99987266789999******************************997 PP
>> tr|W7XD08|W7XD08_TETTS tRNA (guanine(37)-N1)-methyltransferase OS=Tetrahymena thermophila (strain SB210) OX=312017 G
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 16.4 0.0 6.4e-07 0.0058 21 115 .. 205 286 .. 179 306 .. 0.71
Alignments for each domain:
== domain 1 score: 16.4 bits; conditional E-value: 6.4e-07
S--GGGHHHHHHHHHH...HHHHHHHH-S-EEEEESS-TTSHHHHHHHHH-S-EEEEEEE-S-HHHHHHHHHHHHHTT--G.GEEEE CS
TRM 21 FYNPvqefnRDlsvlvirqlellkkklgekikvldaLsasGlRaiRfalEvpgvkevlaNDisekAvelikeNvklnevee.ivvin 106
++ + ++ RD ++ + ++ + +vld + + G aiR a+ +v+ ND++++ ++ + N + n+ve+ ++ +n
tr|W7XD08|W7XD08_TETTS 205 YFCSRLQTERDRVLKL----------IKPNETVLDLFCGVGPLAIRAAKM---GCKVICNDLNPHCYDYLLINREKNNVEDkTLCFN 278
4445555555533333..........2222479***************97...567888*********************9466666 PP
-S-HHHHHC CS
TRM 107 eddAnvlla 115
+ dA+ ++
tr|W7XD08|W7XD08_TETTS 279 N-DARKVVD 286
6.9998876 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (376 nodes)
Target sequences: 26971 (16912921 residues searched)
Passed MSV filter: 2330 (0.0863891); expected 539.4 (0.02)
Passed bias filter: 416 (0.015424); expected 539.4 (0.02)
Passed Vit filter: 35 (0.00129769); expected 27.0 (0.001)
Passed Fwd filter: 3 (0.000111231); expected 0.3 (1e-05)
Initial search space (Z): 26971 [actual number of targets]
Domain search space (domZ): 3 [number of targets reported over threshold]
# CPU time: 0.40u 0.01s 00:00:00.41 Elapsed: 00:00:00.13
# Mc/sec: 48917.37
//
[ok]