# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/TruD.hmm.txt # target sequence database: proteomes/Homo_sapiens.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TruD [M=416] Accession: PF01142.17 Description: tRNA pseudouridine synthase D (TruD) Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 1.4e-73 250.4 0.0 1.9e-69 236.8 0.0 2.2 2 sp|Q9H0K6|PUS7L_HUMAN Pseudouridylate synthase 7 homolog-l 3.7e-73 249.0 0.0 9.6e-68 231.2 0.0 2.3 2 sp|Q96PZ0|PUS7_HUMAN Pseudouridylate synthase 7 homolog O 1.1e-66 227.7 0.0 1.3e-66 227.4 0.0 1.1 1 tr|B3KUJ1|B3KUJ1_HUMAN Pseudouridylate synthase 7 homolog-l 2.3e-45 157.5 0.1 8.2e-40 139.2 0.0 2.2 2 tr|E7EUH7|E7EUH7_HUMAN Pseudouridylate synthase 7 homolog O 1.5e-32 115.3 0.3 1.6e-32 115.1 0.3 1.0 1 tr|F8VW99|F8VW99_HUMAN Pseudouridylate synthase 7 homolog-l 2e-32 114.8 0.5 2.2e-32 114.7 0.5 1.0 1 tr|F8VP66|F8VP66_HUMAN Pseudouridylate synthase 7 homolog-l 1.5e-14 56.0 0.0 4.6e-10 41.2 0.0 2.2 2 tr|F8VZA0|F8VZA0_HUMAN Pseudouridylate synthase 7 homolog-l 0.00039 21.6 0.0 0.12 13.4 0.0 2.1 2 tr|H0Y863|H0Y863_HUMAN Pseudouridylate synthase 7 homolog ( ------ inclusion threshold ------ 0.025 15.7 0.0 0.032 15.3 0.0 1.1 1 tr|F8VWC0|F8VWC0_HUMAN Pseudouridylate synthase 7 homolog-l 1.2 10.2 0.0 1.2 10.2 0.0 1.0 1 tr|M0R0M6|M0R0M6_HUMAN Zinc finger protein 417 (Fragment) O 2.2 9.3 3.9 17 6.4 0.4 2.3 2 sp|Q6ZMZ3-3|SYNE3_HUMAN Isoform 3 of Nesprin-3 OS=Homo sapie Domain annotation for each sequence (and alignments): >> sp|Q9H0K6|PUS7L_HUMAN Pseudouridylate synthase 7 homolog-like protein OS=Homo sapiens GN=PUS7L PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 11.5 0.0 5.6e-05 0.45 6 35 .. 15 43 .. 11 70 .. 0.73 2 ! 236.8 0.0 2.4e-73 1.9e-69 39 416 .] 295 696 .. 279 696 .. 0.86 Alignments for each domain: == domain 1 score: 11.5 bits; conditional E-value: 5.6e-05 TruD 6 lyvtdtegigGrlrespeDFiVeEieefsg 35 +++ d+ g+ G++++sp DFiV Ei e g sp|Q9H0K6|PUS7L_HUMAN 15 CFFNDHVGFHGTIKSSPSDFIVIEIDEQ-G 43 6778999******************655.2 PP == domain 2 score: 236.8 bits; conditional E-value: 2.4e-73 TruD 39 akegey..lvlrvekrnwdtldlvrelaralgisrkrvgfaGtKDkrAvTtQlisirkvepeelekl..ei..kdvelevvgrarrkl 120 +eg++ + ++++k+n ++ +++ la +lg+ +++++aG+KDk+A+T+Q + +rkv+pe+l+++ ei k++++ ++ + + +l sp|Q9H0K6|PUS7L_HUMAN 295 CQEGKViyTAFTLRKENLEMFEAIGFLAIKLGVIPSDFSYAGLKDKKAITYQAMVVRKVTPERLKNIekEIekKRMNVFNIRSVDDSL 382 455665448899*****************************************************9988444488999999******* PP TruD 121 rlGdLaGNkFeirvrdv.aeee...eaakraeeileelkekggvPNyfGvQRFGsrrpv.thlvGkaivkgdleeAveayvgkpfeee 203 rlG+L+GN+F+i++r++ ++ + ++++r+ e +e++k+kg + Ny+G QRFG+ r v t +G a++k+++ +A++ +++ sp|Q9H0K6|PUS7L_HUMAN 383 RLGQLKGNHFDIVIRNLkKQINdsaNLRERIMEAIENVKKKG-FVNYYGPQRFGKGRKVhTDQIGLALLKNEMMKAIKLFLTPED--L 467 ****************85544444455566666666777766.************8875489******************98765..4 PP TruD 204 sedtreareavaetgdleealeelpkslryEramlkrLae...kpkdykkAlealpknLqrlFvhAyqSylFNrvlseRlerglplde 288 ++ +++a++++ +t+d++ l+++p+ Era+l++L + +++ +A +lp+ ++ ++vhAy S ++N+++s Rle + + sp|Q9H0K6|PUS7L_HUMAN 468 DDPVNRAKKYFLQTEDAKGTLSLMPEFKVRERALLEALHRfgmTEEGCIQAWFSLPHSMRIFYVHAYTSKIWNEAVSYRLETY--GAR 553 5556799*********************************88888889999999***************************99..57* PP TruD 289 pveGDvvifaeer...lpdtdrlqlvteknveevkrliergrafvtaplvGtetelaegevgeierevleeegleledFklpklpels 373 +v+GD+v+ +e+ + +++++lvte++ + +v++p++G++ + ++ +vg+ +++l+++gl++ Fk+p+ +l+ sp|Q9H0K6|PUS7L_HUMAN 554 VVQGDLVCLDEDIddeNFPNSKIHLVTEEEGSANMYA----IHQVVLPVLGYNIQYPKNKVGQWYHDILSRDGLQTCRFKVPT-LKLN 636 *********9877666666777888877665544433....34799************************************8.9*** PP TruD 374 skGtrRaillrve.................dlelsaeedeltleFsLpkGsYATvvlrEi 416 G +R+il ++ +++++ +l+++F L+ +YATv l+Ei sp|Q9H0K6|PUS7L_HUMAN 637 IPGCYRQILKHPCnlsyqlmedhdidvktkGSHIDETALSLLISFDLDASCYATVCLKEI 696 ********9988889999***99887765544455555569*****************97 PP >> sp|Q96PZ0|PUS7_HUMAN Pseudouridylate synthase 7 homolog OS=Homo sapiens GN=PUS7 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 15.6 0.0 3.3e-06 0.027 2 32 .. 114 144 .. 113 194 .. 0.87 2 ! 231.2 0.0 1.2e-71 9.6e-68 39 416 .] 252 642 .. 240 642 .. 0.93 Alignments for each domain: == domain 1 score: 15.6 bits; conditional E-value: 3.3e-06 TruD 2 lgielyvtdtegigGrlrespeDFiVeEiee 32 +gi +v++++g+ G l+e++ DF+V+Ei + sp|Q96PZ0|PUS7_HUMAN 114 VGITKFVSSHQGFSGILKERYSDFVVHEIGK 144 89***************************54 PP == domain 2 score: 231.2 bits; conditional E-value: 1.2e-71 TruD 39 akegeylvlrvekrnwdtldlvrelaralgisrkrvgfaGtKDkrAvTtQlisirkvepeelekl..eikdvelevvgrarrklrlGdL 125 +++g+y+ + + k+n dt+d+++ l++ l+++ + ++++GtKDkrA+T+Q i++ k+++++l++l + + +l ++ ++++l+lG+L sp|Q96PZ0|PUS7_HUMAN 252 KSRGSYCHFVLYKENKDTMDAINVLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLnkCLMNFKLGNFSYQKNPLKLGEL 340 578***********************************************************9996668******************** PP TruD 126 aGNkFeirvrdvaeeeeaakraeeileelkekggvPNyfGvQRFGsrrpvthlvGkaivkgdleeAveayvgkpfeeesedtreareav 214 +GN+F++++r+++ ++ +++++ +++lke g + Ny+G+QRFG++ t+ vG+ai+++ + e ++ ++ + +e+ + re sp|Q96PZ0|PUS7_HUMAN 341 QGNHFTVVLRNITGTD---DQVQQAMNSLKEIG-FINYYGMQRFGTTAVPTYQVGRAILQNSWTEVMDLILKPRSGAEKGYLVKCREEW 425 ***********95444...59**********99.*******************************99999999999************* PP TruD 215 aetgdleealeelpkslryEramlkrLae.kpkdykkAlealpknLqrlFvhAyqSylFNrvlseRlerglpldepveGDvvifaeerl 302 a+t+d ++al++lp + +E ++l+ L + k++ +A+ +p+n + +++h+yqSy++N+++s+R+e++ +pv+GD+v++ + sp|Q96PZ0|PUS7_HUMAN 426 AKTKDPTAALRKLPVKRCVEGQLLRGLSKyGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNNMVSKRIEDY-G-LKPVPGDLVLKGATA- 511 *****************************77899**********************************99.4.48*******999554. PP TruD 303 pdtdrlqlvteknveevkrliergrafvtaplvGtetelaegevgeierevleeegleledFklpklpelsskGtrRaillrve..... 386 ++e+ v++++ v++pl+G+++ ++ + +e re+l ++l+ ++ + +k+ + s +G++R+i++r++ sp|Q96PZ0|PUS7_HUMAN 512 ------TYIEEDDVNNYS------IHDVVMPLPGFDVIYPKHKIQEAYREMLTADNLDIDNMR-HKIRDYSLSGAYRKIIIRPQnvswe 587 ......667776666666......45799*********************************9.5689********************* PP TruD 387 .........................dlelsaeedeltleFsLpkGsYATvvlrEi 416 ++ + + + l+++FsLp+ +YAT+ +rE+ sp|Q96PZ0|PUS7_HUMAN 588 vvayddpkiplfntdvdnlegktppVFASEGKYRALKMDFSLPPSTYATMAIREV 642 *******************9999875666666777******************96 PP >> tr|B3KUJ1|B3KUJ1_HUMAN Pseudouridylate synthase 7 homolog-like protein OS=Homo sapiens GN=PUS7L PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 227.4 0.0 1.6e-70 1.3e-66 59 416 .] 4 383 .. 1 383 [. 0.87 Alignments for each domain: == domain 1 score: 227.4 bits; conditional E-value: 1.6e-70 TruD 59 lvrelaralgisrkrvgfaGtKDkrAvTtQlisirkvepeelekl..ei..kdvelevvgrarrklrlGdLaGNkFeirvrdv.aee 140 ++ la +lg+ +++++aG+KDk+A+T+Q + +rkv+pe+l+++ ei k++++ ++ + + +lrlG+L+GN+F+i++r++ ++ tr|B3KUJ1|B3KUJ1_HUMAN 4 AIGFLAIKLGVIPSDFSYAGLKDKKAITYQAMVVRKVTPERLKNIekEIekKRMNVFNIRSVDDSLRLGQLKGNHFDIVIRNLkKQI 90 67779999***********************************9988444488999999***********************85544 PP TruD 141 e...eaakraeeileelkekggvPNyfGvQRFGsrrpv.thlvGkaivkgdleeAveayvgkpfeeesedtreareavaetgdleea 223 + ++++r+ e +e++k+kg + Ny+G QRFG+ r v t +G a++k+++ +A++ +++ ++ +++a++++ +t+d++ tr|B3KUJ1|B3KUJ1_HUMAN 91 NdsaNLRERIMEAIENVKKKG-FVNYYGPQRFGKGRKVhTDQIGLALLKNEMMKAIKLFLTPED--LDDPVNRAKKYFLQTEDAKGT 174 444455566666666777766.************8875489******************98765..45556799************* PP TruD 224 leelpkslryEramlkrLae...kpkdykkAlealpknLqrlFvhAyqSylFNrvlseRlerglpldepveGDvvifaeer...lpd 304 l+++p+ Era+l++L + +++ +A +lp+ ++ ++vhAy S ++N+++s Rle + ++v+GD+v+ +e+ + tr|B3KUJ1|B3KUJ1_HUMAN 175 LSLMPEFKVRERALLEALHRfgmTEEGCIQAWFSLPHSMRIFYVHAYTSKIWNEAVSYRLETY--GARVVQGDLVCLDEDIddeNFP 259 ********************88888889999999***************************99..57**********9877666666 PP TruD 305 tdrlqlvteknveevkrliergrafvtaplvGtetelaegevgeierevleeegleledFklpklpelsskGtrRaillrve..... 386 +++++lvte++ + +v++p++G++ + ++ +vg+ +++l+++gl++ Fk+p+ +l+ G +R+il ++ tr|B3KUJ1|B3KUJ1_HUMAN 260 NSKIHLVTEEEGSANMYA----IHQVVLPVLGYNIQYPKNKVGQWYHDILSRDGLQTCRFKVPT-LKLNIPGCYRQILKHPCnlsyq 341 777888877665544433....34799************************************8.9***********9988889999 PP TruD 387 ............dlelsaeedeltleFsLpkGsYATvvlrEi 416 +++++ +l+++F L+ +YATv l+Ei tr|B3KUJ1|B3KUJ1_HUMAN 342 lmedhdidvktkGSHIDETALSLLISFDLDASCYATVCLKEI 383 ***99887765544455555569*****************97 PP >> tr|E7EUH7|E7EUH7_HUMAN Pseudouridylate synthase 7 homolog OS=Homo sapiens GN=PUS7 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 16.3 0.0 2e-06 0.016 2 33 .. 114 145 .. 113 196 .. 0.87 2 ! 139.2 0.0 1e-43 8.2e-40 39 230 .. 252 441 .. 240 445 .. 0.94 Alignments for each domain: == domain 1 score: 16.3 bits; conditional E-value: 2e-06 TruD 2 lgielyvtdtegigGrlrespeDFiVeEieef 33 +gi +v++++g+ G l+e++ DF+V+Ei + tr|E7EUH7|E7EUH7_HUMAN 114 VGITKFVSSHQGFSGILKERYSDFVVHEIGKD 145 89***************************554 PP == domain 2 score: 139.2 bits; conditional E-value: 1e-43 TruD 39 akegeylvlrvekrnwdtldlvrelaralgisrkrvgfaGtKDkrAvTtQlisirkvepeelekl..eikdvelevvgrarrklrlG 123 +++g+y+ + + k+n dt+d+++ l++ l+++ + ++++GtKDkrA+T+Q i++ k+++++l++l + + +l ++ ++++l+lG tr|E7EUH7|E7EUH7_HUMAN 252 KSRGSYCHFVLYKENKDTMDAINVLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLnkCLMNFKLGNFSYQKNPLKLG 338 578***********************************************************9996668****************** PP TruD 124 dLaGNkFeirvrdvaeeeeaakraeeileelkekggvPNyfGvQRFGsrrpvthlvGkaivkgdleeAveayvgkpfeeesedtrea 210 +L+GN+F++++r+++ ++ +++++ +++lke g + Ny+G+QRFG++ t+ vG+ai+++ + e ++ ++ + +e+ + tr|E7EUH7|E7EUH7_HUMAN 339 ELQGNHFTVVLRNITGTD---DQVQQAMNSLKEIG-FINYYGMQRFGTTAVPTYQVGRAILQNSWTEVMDLILKPRSGAEKGYLVKC 421 *************95444...59**********99.*******************************99999999999********* PP TruD 211 reavaetgdleealeelpks 230 re a+t+d ++al++lp + tr|E7EUH7|E7EUH7_HUMAN 422 REEWAKTKDPTAALRKLPVK 441 *****************976 PP >> tr|F8VW99|F8VW99_HUMAN Pseudouridylate synthase 7 homolog-like protein (Fragment) OS=Homo sapiens GN=PUS7L PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 115.1 0.3 2e-36 1.6e-32 59 197 .. 4 150 .. 1 159 [. 0.85 Alignments for each domain: == domain 1 score: 115.1 bits; conditional E-value: 2e-36 TruD 59 lvrelaralgisrkrvgfaGtKDkrAvTtQlisirkvepeelekl..ei..kdvelevvgrarrklrlGdLaGNkFeirvrdv.aee 140 ++ la +lg+ +++++aG+KDk+A+T+Q + +rkv+pe+l+++ ei k++++ ++ + + +lrlG+L+GN+F+i++r++ ++ tr|F8VW99|F8VW99_HUMAN 4 AIGFLAIKLGVIPSDFSYAGLKDKKAITYQAMVVRKVTPERLKNIekEIekKRMNVFNIRSVDDSLRLGQLKGNHFDIVIRNLkKQI 90 67789999***********************************9988444488999999***********************85544 PP TruD 141 e...eaakraeeileelkekggvPNyfGvQRFGsrrpv.thlvGkaivkgdleeAveayvg 197 + ++++r+ e +e++k+kg + Ny+G QRFG+ r v t +G a++k+++ +A++ +++ tr|F8VW99|F8VW99_HUMAN 91 NdsaNLRERIMEAIENVKKKG-FVNYYGPQRFGKGRKVhTDQIGLALLKNEMMKAIKLFLT 150 444455566666666777766.************8875489****************9986 PP >> tr|F8VP66|F8VP66_HUMAN Pseudouridylate synthase 7 homolog-like protein (Fragment) OS=Homo sapiens GN=PUS7L PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 114.7 0.5 2.7e-36 2.2e-32 59 197 .. 4 150 .. 1 153 [. 0.86 Alignments for each domain: == domain 1 score: 114.7 bits; conditional E-value: 2.7e-36 TruD 59 lvrelaralgisrkrvgfaGtKDkrAvTtQlisirkvepeelekl..ei..kdvelevvgrarrklrlGdLaGNkFeirvrdv.aee 140 ++ la +lg+ +++++aG+KDk+A+T+Q + +rkv+pe+l+++ ei k++++ ++ + + +lrlG+L+GN+F+i++r++ ++ tr|F8VP66|F8VP66_HUMAN 4 AIGFLAIKLGVIPSDFSYAGLKDKKAITYQAMVVRKVTPERLKNIekEIekKRMNVFNIRSVDDSLRLGQLKGNHFDIVIRNLkKQI 90 67789999***********************************9988444488999999***********************85544 PP TruD 141 e...eaakraeeileelkekggvPNyfGvQRFGsrrpv.thlvGkaivkgdleeAveayvg 197 + ++++r+ e +e++k+kg + Ny+G QRFG+ r v t +G a++k+++ +A++ +++ tr|F8VP66|F8VP66_HUMAN 91 NdsaNLRERIMEAIENVKKKG-FVNYYGPQRFGKGRKVhTDQIGLALLKNEMMKAIKLFLT 150 444455566666666777766.************8875489***************99886 PP >> tr|F8VZA0|F8VZA0_HUMAN Pseudouridylate synthase 7 homolog-like protein OS=Homo sapiens GN=PUS7L PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 12.8 0.0 2.4e-05 0.19 6 35 .. 15 43 .. 11 70 .. 0.73 2 ! 41.2 0.0 5.7e-14 4.6e-10 39 104 .. 295 362 .. 279 365 .] 0.88 Alignments for each domain: == domain 1 score: 12.8 bits; conditional E-value: 2.4e-05 TruD 6 lyvtdtegigGrlrespeDFiVeEieefsg 35 +++ d+ g+ G++++sp DFiV Ei e g tr|F8VZA0|F8VZA0_HUMAN 15 CFFNDHVGFHGTIKSSPSDFIVIEIDEQ-G 43 6788999******************655.2 PP == domain 2 score: 41.2 bits; conditional E-value: 5.7e-14 TruD 39 akegey..lvlrvekrnwdtldlvrelaralgisrkrvgfaGtKDkrAvTtQlisirkvepeelekle 104 +eg++ + ++++k+n ++ +++ la +lg+ +++++aG+KDk+A+T+Q + +rkv+pe+l+++e tr|F8VZA0|F8VZA0_HUMAN 295 CQEGKViyTAFTLRKENLEMFEAIGFLAIKLGVIPSDFSYAGLKDKKAITYQAMVVRKVTPERLKNIE 362 456665448899***************************************************99874 PP >> tr|H0Y863|H0Y863_HUMAN Pseudouridylate synthase 7 homolog (Fragment) OS=Homo sapiens GN=PUS7 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 6.8 0.0 0.0016 13 16 33 .. 3 20 .. 1 65 [. 0.82 2 ! 13.4 0.0 1.5e-05 0.12 39 78 .. 93 132 .] 80 132 .] 0.89 Alignments for each domain: == domain 1 score: 6.8 bits; conditional E-value: 0.0016 TruD 16 GrlrespeDFiVeEieef 33 G l+e++ DF+V+Ei + tr|H0Y863|H0Y863_HUMAN 3 GILKERYSDFVVHEIGKD 20 89*************544 PP == domain 2 score: 13.4 bits; conditional E-value: 1.5e-05 TruD 39 akegeylvlrvekrnwdtldlvrelaralgisrkrvgfaG 78 +++g+y+ + + k+n dt+d+++ l++ l+++ + ++++G tr|H0Y863|H0Y863_HUMAN 93 KSRGSYCHFVLYKENKDTMDAINVLSKYLRVKPNIFSYMG 132 678*****************************99999988 PP >> tr|F8VWC0|F8VWC0_HUMAN Pseudouridylate synthase 7 homolog-like protein (Fragment) OS=Homo sapiens GN=PUS7L PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.3 0.0 4e-06 0.032 6 36 .. 15 44 .. 11 70 .. 0.71 Alignments for each domain: == domain 1 score: 15.3 bits; conditional E-value: 4e-06 TruD 6 lyvtdtegigGrlrespeDFiVeEieefsge 36 +++ d+ g+ G++++sp DFiV Ei e g+ tr|F8VWC0|F8VWC0_HUMAN 15 CFFNDHVGFHGTIKSSPSDFIVIEIDEQ-GQ 44 6788999******************655.22 PP >> tr|M0R0M6|M0R0M6_HUMAN Zinc finger protein 417 (Fragment) OS=Homo sapiens GN=ZNF417 PE=2 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.2 0.0 0.00014 1.2 76 102 .. 14 40 .. 5 49 .. 0.85 Alignments for each domain: == domain 1 score: 10.2 bits; conditional E-value: 0.00014 TruD 76 faGtKDkrAvTtQlisirkvepeelek 102 ++G KD +A +Q is+++ ++++ ++ tr|M0R0M6|M0R0M6_HUMAN 14 WCGSKDEEAPCKQRISVQRESQSRTPR 40 9****************8877766665 PP >> sp|Q6ZMZ3-3|SYNE3_HUMAN Isoform 3 of Nesprin-3 OS=Homo sapiens GN=SYNE3 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 6.4 0.4 0.0021 17 179 244 .. 293 360 .. 281 398 .. 0.76 2 ? 3.8 0.2 0.012 99 225 264 .. 530 569 .. 512 573 .. 0.86 Alignments for each domain: == domain 1 score: 6.4 bits; conditional E-value: 0.0021 TruD 179 vGkaivkgdleeAveayvgkpfeeesedtreareavaetgdleealeelpkslryEramlkrLae...k 244 +G + + g+lee ++ + k +e+ ++ r ++ +g +e+ +++l +l+ r++l+rLa+ + sp|Q6ZMZ3-3|SYNE3_HUMAN 293 LGAEKITGELEEM-RKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQeglQ 360 5666666777664.444445555556666889********************************94431 PP == domain 2 score: 3.8 bits; conditional E-value: 0.012 TruD 225 eelpkslryEramlkrLaekpkdykkAlealpknLqrlFv 264 ++l++sl ++ l++L ++kd+ +A+e l+++L +l v sp|Q6ZMZ3-3|SYNE3_HUMAN 530 DLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQV 569 6788999999999**********************99866 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (416 nodes) Target sequences: 88473 (35070517 residues searched) Passed MSV filter: 2972 (0.0335922); expected 1769.5 (0.02) Passed bias filter: 1504 (0.0169995); expected 1769.5 (0.02) Passed Vit filter: 150 (0.00169543); expected 88.5 (0.001) Passed Fwd filter: 14 (0.00015824); expected 0.9 (1e-05) Initial search space (Z): 88473 [actual number of targets] Domain search space (domZ): 11 [number of targets reported over threshold] # CPU time: 1.00u 0.03s 00:00:01.03 Elapsed: 00:00:00.30 # Mc/sec: 48631.12 // [ok]